TRIM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.63877855
2positive regulation of gamma-delta T cell activation (GO:0046645)4.21205120
3cellular response to ethanol (GO:0071361)4.02006369
4interleukin-6-mediated signaling pathway (GO:0070102)3.69423345
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.69305946
6regulation of gamma-delta T cell differentiation (GO:0045586)3.64946258
7regulation of gamma-delta T cell activation (GO:0046643)3.53947647
8indolalkylamine metabolic process (GO:0006586)3.48512937
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.45002813
10indole-containing compound catabolic process (GO:0042436)3.41026893
11indolalkylamine catabolic process (GO:0046218)3.41026893
12tryptophan catabolic process (GO:0006569)3.41026893
13negative regulation of complement activation (GO:0045916)3.35719675
14regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.31380814
15negative regulation of cAMP-mediated signaling (GO:0043951)3.29314151
16regulation of memory T cell differentiation (GO:0043380)3.27338163
17tryptophan metabolic process (GO:0006568)3.20243252
18positive regulation of granulocyte differentiation (GO:0030854)3.11406884
19negative thymic T cell selection (GO:0045060)3.07562256
20negative regulation of protein activation cascade (GO:2000258)3.07375283
21cilium or flagellum-dependent cell motility (GO:0001539)3.05670868
22negative regulation of humoral immune response (GO:0002921)3.04740274
23hepatocyte apoptotic process (GO:0097284)3.03539462
24phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.03346546
25negative T cell selection (GO:0043383)3.02811234
26negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98624919
27negative regulation of T-helper cell differentiation (GO:0045623)2.98624919
28establishment of protein localization to Golgi (GO:0072600)2.98061084
29negative regulation of cell killing (GO:0031342)2.93795702
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93795702
31response to type I interferon (GO:0034340)2.93723139
32sphingoid metabolic process (GO:0046519)2.92275711
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91125361
34signal peptide processing (GO:0006465)2.90953702
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90695827
36cytokine biosynthetic process (GO:0042089)2.90441169
37antigen processing and presentation of endogenous antigen (GO:0019883)2.89675811
38positive regulation of B cell differentiation (GO:0045579)2.88143034
39UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87730260
40histone H3-K36 demethylation (GO:0070544)2.87659495
41cellular response to type I interferon (GO:0071357)2.86882485
42type I interferon signaling pathway (GO:0060337)2.86882485
43B cell receptor signaling pathway (GO:0050853)2.75810542
44negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.71516813
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71071566
46lipid translocation (GO:0034204)2.70978373
47phospholipid translocation (GO:0045332)2.70978373
48regulation of MHC class I biosynthetic process (GO:0045343)2.68040647
49monoubiquitinated protein deubiquitination (GO:0035520)2.62966461
50protein K48-linked deubiquitination (GO:0071108)2.61679460
51tachykinin receptor signaling pathway (GO:0007217)2.61558389
52response to interleukin-15 (GO:0070672)2.61185623
53regulation of establishment of cell polarity (GO:2000114)2.58558262
54regulation of B cell differentiation (GO:0045577)2.58099322
55regulation of alpha-beta T cell proliferation (GO:0046640)2.57623278
56kynurenine metabolic process (GO:0070189)2.57605111
57cellular response to interleukin-15 (GO:0071350)2.57128130
58cytokine metabolic process (GO:0042107)2.55378452
59cellular extravasation (GO:0045123)2.52349541
60protein K63-linked deubiquitination (GO:0070536)2.45079708
61xenobiotic catabolic process (GO:0042178)2.43888913
62negative regulation of lymphocyte mediated immunity (GO:0002707)2.43104684
63positive regulation of developmental pigmentation (GO:0048087)2.42781272
64negative regulation of calcium ion transport into cytosol (GO:0010523)2.40918524
65negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.40766371
66definitive hemopoiesis (GO:0060216)2.40686488
67positive regulation of alpha-beta T cell proliferation (GO:0046641)2.40417466
68protein targeting to lysosome (GO:0006622)2.38458716
69establishment of protein localization to vacuole (GO:0072666)2.38458716
70protein targeting to vacuole (GO:0006623)2.38458716
71protein targeting to Golgi (GO:0000042)2.37096723
72positive regulation of T cell mediated cytotoxicity (GO:0001916)2.35187558
73negative regulation of adaptive immune response (GO:0002820)2.34575194
74T-helper cell differentiation (GO:0042093)2.33507362
75CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.33507362
76negative regulation of mast cell activation (GO:0033004)2.31775068
77retrograde transport, vesicle recycling within Golgi (GO:0000301)2.31409303
78regulation of regulatory T cell differentiation (GO:0045589)2.30544899
79T cell selection (GO:0045058)2.30108499
80positive regulation of natural killer cell activation (GO:0032816)2.29956376
81interkinetic nuclear migration (GO:0022027)2.29001868
82regulation of T-helper 1 cell differentiation (GO:0045625)2.28034244
83detection of molecule of bacterial origin (GO:0032490)2.27806109
84negative regulation of B cell mediated immunity (GO:0002713)2.27077815
85negative regulation of immunoglobulin mediated immune response (GO:0002890)2.27077815
86interferon-gamma-mediated signaling pathway (GO:0060333)2.26505655
87detection of other organism (GO:0098543)2.23859094
88JAK-STAT cascade (GO:0007259)2.23260922
89regulation of T cell mediated cytotoxicity (GO:0001914)2.22952217
90iron ion import (GO:0097286)2.22877521
91detection of bacterium (GO:0016045)2.21459832
92detection of external biotic stimulus (GO:0098581)2.21085164
93positive regulation of DNA recombination (GO:0045911)2.21039344
94regulation of establishment or maintenance of cell polarity (GO:0032878)2.16754473
95regulation of interleukin-12 biosynthetic process (GO:0045075)2.16676354
96snRNA transcription (GO:0009301)2.15918940
97benzene-containing compound metabolic process (GO:0042537)2.15104831
98T cell migration (GO:0072678)2.14791807
99regulation of mast cell activation (GO:0033003)2.13363923
100macrophage activation involved in immune response (GO:0002281)2.10243874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.26694649
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.05179837
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.29897586
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.87683506
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.62612590
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.32681895
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18810024
8RUNX_20019798_ChIP-Seq_JUKART_Human2.14805490
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06982216
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90945768
11FLI1_27457419_Chip-Seq_LIVER_Mouse1.87828045
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87211268
13SCL_19346495_ChIP-Seq_HPC-7_Human1.82075983
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81376069
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79164077
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76384663
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75721911
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.75425473
19VDR_22108803_ChIP-Seq_LS180_Human1.73136552
20ER_23166858_ChIP-Seq_MCF-7_Human1.71542135
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.70570980
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69594579
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69480774
24GBX2_23144817_ChIP-Seq_PC3_Human1.69183631
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66629002
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66583542
27VDR_24787735_ChIP-Seq_THP-1_Human1.61999673
28MYB_26560356_Chip-Seq_TH2_Human1.61237301
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58593101
30IGF1R_20145208_ChIP-Seq_DFB_Human1.58285113
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57785567
32GATA1_22025678_ChIP-Seq_K562_Human1.57371751
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56400408
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53559147
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52340643
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51467127
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50411831
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48358471
39GATA3_26560356_Chip-Seq_TH2_Human1.46024557
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.44737614
41STAT3_23295773_ChIP-Seq_U87_Human1.43312914
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40803905
43GATA3_27048872_Chip-Seq_THYMUS_Human1.39034296
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38403182
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35657763
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35559971
47BCAT_22108803_ChIP-Seq_LS180_Human1.34938641
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31962955
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31610963
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30993356
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30063168
52SPI1_23127762_ChIP-Seq_K562_Human1.29134326
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.28892847
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27144623
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.24448060
56AHR_22903824_ChIP-Seq_MCF-7_Human1.24225614
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23049446
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23049446
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.21879389
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.20939222
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.20554319
62MYB_26560356_Chip-Seq_TH1_Human1.19039755
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.17093598
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15623025
65SMAD4_21799915_ChIP-Seq_A2780_Human1.15567925
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15368474
67TP53_16413492_ChIP-PET_HCT116_Human1.15058409
68TCF4_23295773_ChIP-Seq_U87_Human1.14937724
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14246701
70* CDX2_22108803_ChIP-Seq_LS180_Human1.14021043
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13971101
72TP63_23658742_ChIP-Seq_EP156T_Human1.13600676
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13435950
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12821861
75ZNF274_21170338_ChIP-Seq_K562_Hela1.11815182
76* SMRT_27268052_Chip-Seq_Bcells_Human1.11663438
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10165709
78CJUN_26792858_Chip-Seq_BT549_Human1.09118918
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09015534
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.08734784
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.07301761
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07232194
83AR_21572438_ChIP-Seq_LNCaP_Human1.06273143
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04769925
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04611762
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.02119945
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02002068
88P300_19829295_ChIP-Seq_ESCs_Human1.01479687
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.01225085
90BRD4_25478319_ChIP-Seq_HGPS_Human1.00583839
91FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98405973
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98389832
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97669860
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97052822
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96650429
96FOXO3_23340844_ChIP-Seq_DLD1_Human0.95366211
97TCF4_22108803_ChIP-Seq_LS180_Human0.94691390
98CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93975232
99CBP_20019798_ChIP-Seq_JUKART_Human0.93421015
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93421015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation2.77700157
2MP0001835_abnormal_antigen_presentation2.69596033
3MP0003763_abnormal_thymus_physiology2.39689468
4MP0002166_altered_tumor_susceptibility2.38362161
5MP0003045_fibrosis2.30246922
6MP0009785_altered_susceptibility_to2.25971673
7MP0003195_calcinosis2.22732939
8MP0000685_abnormal_immune_system2.22102338
9MP0005671_abnormal_response_to2.21897211
10MP0003724_increased_susceptibility_to2.16878850
11MP0008057_abnormal_DNA_replication2.11790139
12MP0003950_abnormal_plasma_membrane2.07366451
13MP0006054_spinal_hemorrhage2.06407699
14MP0001800_abnormal_humoral_immune2.01518893
15MP0001790_abnormal_immune_system1.94821914
16MP0005387_immune_system_phenotype1.94821914
17MP0006082_CNS_inflammation1.92641381
18MP0001501_abnormal_sleep_pattern1.87520109
19MP0005000_abnormal_immune_tolerance1.82707270
20MP0003172_abnormal_lysosome_physiology1.77048709
21MP0003436_decreased_susceptibility_to1.76981142
22MP0002148_abnormal_hypersensitivity_rea1.75605643
23MP0005310_abnormal_salivary_gland1.69248172
24MP0002009_preneoplasia1.67736349
25MP0002723_abnormal_immune_serum1.67312972
26MP0003300_gastrointestinal_ulcer1.66596645
27MP0002452_abnormal_antigen_presenting1.65999848
28MP0005025_abnormal_response_to1.64165154
29MP0003252_abnormal_bile_duct1.64022586
30MP0002419_abnormal_innate_immunity1.62704434
31MP0003191_abnormal_cellular_cholesterol1.61647100
32MP0004381_abnormal_hair_follicle1.59830883
33MP0009278_abnormal_bone_marrow1.57942165
34MP0005075_abnormal_melanosome_morpholog1.55980747
35MP0000015_abnormal_ear_pigmentation1.53937958
36MP0001873_stomach_inflammation1.53454008
37MP0002420_abnormal_adaptive_immunity1.52150543
38MP0003656_abnormal_erythrocyte_physiolo1.51895360
39MP0002006_tumorigenesis1.50486368
40MP0002405_respiratory_system_inflammati1.50218892
41MP0001819_abnormal_immune_cell1.50139618
42MP0005397_hematopoietic_system_phenotyp1.49034903
43MP0001545_abnormal_hematopoietic_system1.49034903
44MP0000371_diluted_coat_color1.47525368
45MP0002876_abnormal_thyroid_physiology1.45374699
46MP0002168_other_aberrant_phenotype1.41167460
47MP0000465_gastrointestinal_hemorrhage1.39888529
48MP0009333_abnormal_splenocyte_physiolog1.39134157
49MP0010155_abnormal_intestine_physiology1.35943667
50MP0009840_abnormal_foam_cell1.34400411
51MP0009764_decreased_sensitivity_to1.32032433
52MP0002138_abnormal_hepatobiliary_system1.31836305
53MP0005451_abnormal_body_composition1.29408860
54MP0004947_skin_inflammation1.29346503
55MP0000427_abnormal_hair_cycle1.28706029
56MP0005174_abnormal_tail_pigmentation1.26602886
57MP0005464_abnormal_platelet_physiology1.25742852
58MP0002398_abnormal_bone_marrow1.22042450
59MP0000716_abnormal_immune_system1.21675091
60MP0001845_abnormal_inflammatory_respons1.20709705
61MP0005164_abnormal_response_to1.19171512
62MP0001533_abnormal_skeleton_physiology1.16881977
63MP0005360_urolithiasis1.16448708
64MP0002693_abnormal_pancreas_physiology1.16133074
65MP0002998_abnormal_bone_remodeling1.15641726
66MP0000689_abnormal_spleen_morphology1.14825582
67MP0002396_abnormal_hematopoietic_system1.13843279
68MP0004883_abnormal_blood_vessel1.13430312
69MP0008469_abnormal_protein_level1.08816506
70MP0002722_abnormal_immune_system1.04909224
71MP0001851_eye_inflammation1.04805898
72MP0004043_abnormal_pH_regulation1.03389626
73MP0002933_joint_inflammation1.01056906
74MP0009780_abnormal_chondrocyte_physiolo1.00476266
75MP0005647_abnormal_sex_gland0.99291276
76MP0005365_abnormal_bile_salt0.98371823
77MP0003303_peritoneal_inflammation0.94435260
78MP0000703_abnormal_thymus_morphology0.91927302
79MP0002429_abnormal_blood_cell0.90632941
80MP0010329_abnormal_lipoprotein_level0.89037168
81MP0003866_abnormal_defecation0.88931974
82MP0000383_abnormal_hair_follicle0.87980560
83MP0005275_abnormal_skin_tensile0.86053380
84MP0000372_irregular_coat_pigmentation0.85439006
85MP0002132_abnormal_respiratory_system0.84843443
86MP0001986_abnormal_taste_sensitivity0.84651353
87MP0000249_abnormal_blood_vessel0.83045155
88MP0004264_abnormal_extraembryonic_tissu0.82250480
89MP0003183_abnormal_peptide_metabolism0.81656717
90MP0005085_abnormal_gallbladder_physiolo0.81389714
91MP0003868_abnormal_feces_composition0.75135462
92MP0010678_abnormal_skin_adnexa0.74792142
93MP0004808_abnormal_hematopoietic_stem0.74011378
94MP0010386_abnormal_urinary_bladder0.72376503
95MP0005167_abnormal_blood-brain_barrier0.71992362
96MP0005376_homeostasis/metabolism_phenot0.70629369
97MP0002971_abnormal_brown_adipose0.70410583
98MP0003943_abnormal_hepatobiliary_system0.70329707
99MP0002095_abnormal_skin_pigmentation0.70188659
100MP0005670_abnormal_white_adipose0.68766639

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)4.48890109
2Optic neuritis (HP:0100653)4.42962303
3Retrobulbar optic neuritis (HP:0100654)4.42962303
4Myositis (HP:0100614)4.38195932
5Keratoconjunctivitis sicca (HP:0001097)3.41845843
6Keratoconjunctivitis (HP:0001096)3.33254834
7Abnormality of T cell number (HP:0011839)3.19504057
8T lymphocytopenia (HP:0005403)3.09664435
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.09638048
10Autoimmune hemolytic anemia (HP:0001890)3.06098971
11Elevated erythrocyte sedimentation rate (HP:0003565)3.03734726
12Recurrent bacterial skin infections (HP:0005406)2.94615988
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87857369
14Hypoproteinemia (HP:0003075)2.78678812
15Recurrent abscess formation (HP:0002722)2.74063727
16Abnormality of B cell number (HP:0010975)2.73397236
17Attenuation of retinal blood vessels (HP:0007843)2.73163031
18Increased cerebral lipofuscin (HP:0011813)2.72060666
19Pulmonary infiltrates (HP:0002113)2.71763453
20Chronic diarrhea (HP:0002028)2.70972754
21Hematochezia (HP:0002573)2.70218177
22Hemoptysis (HP:0002105)2.64232841
23Clumsiness (HP:0002312)2.53260248
24Recurrent fungal infections (HP:0002841)2.52407292
25Hyperventilation (HP:0002883)2.51828336
26Vasculitis (HP:0002633)2.50413055
27Spontaneous hematomas (HP:0007420)2.46305378
28Eczematoid dermatitis (HP:0000976)2.44441327
29Thyroiditis (HP:0100646)2.41806200
30Gaze-evoked nystagmus (HP:0000640)2.41415788
31Encephalitis (HP:0002383)2.40158743
32Stomatitis (HP:0010280)2.39726028
33Arterial thrombosis (HP:0004420)2.39452348
34Eosinophilia (HP:0001880)2.39127193
35Anorexia (HP:0002039)2.38945288
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.35503208
37Keratitis (HP:0000491)2.35395286
38Panhypogammaglobulinemia (HP:0003139)2.34496087
39Genetic anticipation (HP:0003743)2.33152586
40Fair hair (HP:0002286)2.32731478
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29845002
42Abnormality of polysaccharide metabolism (HP:0011012)2.29845002
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29845002
44Mucopolysacchariduria (HP:0008155)2.29832956
45Urinary glycosaminoglycan excretion (HP:0003541)2.29832956
46Gingival bleeding (HP:0000225)2.28205777
47Pustule (HP:0200039)2.25555766
48Ketoacidosis (HP:0001993)2.25474043
49Portal hypertension (HP:0001409)2.23231218
50Meningitis (HP:0001287)2.22412623
51Abnormality of T cells (HP:0002843)2.22162353
52Epistaxis (HP:0000421)2.22063762
53Facial diplegia (HP:0001349)2.20463806
54Gangrene (HP:0100758)2.17958589
55Abnormality of the hepatic vasculature (HP:0006707)2.17915550
56Generalized hypopigmentation of hair (HP:0011358)2.17147892
57Granulocytopenia (HP:0001913)2.16504568
58Constricted visual fields (HP:0001133)2.16337795
59Recurrent viral infections (HP:0004429)2.15619901
60Central scotoma (HP:0000603)2.15077817
61Albinism (HP:0001022)2.14011529
62B lymphocytopenia (HP:0010976)2.13310663
63Pulmonary embolism (HP:0002204)2.12980054
64Abnormality of eosinophils (HP:0001879)2.12375912
65Protruding tongue (HP:0010808)2.11990649
66Dysostosis multiplex (HP:0000943)2.11911308
67Prostate neoplasm (HP:0100787)2.11584995
68Prolonged bleeding time (HP:0003010)2.10628366
69Congenital sensorineural hearing impairment (HP:0008527)2.10036128
70Gastrointestinal infarctions (HP:0005244)2.09756005
71Recurrent skin infections (HP:0001581)2.05166338
72Inflammation of the large intestine (HP:0002037)2.04063632
73Recurrent bronchitis (HP:0002837)1.99668105
74Abnormality of the pleura (HP:0002103)1.95829768
75Colitis (HP:0002583)1.95369469
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93229558
77Abnormality of the renal cortex (HP:0011035)1.91239766
78Abnormality of the pericardium (HP:0001697)1.90782924
79Joint swelling (HP:0001386)1.90042990
80Autoimmune thrombocytopenia (HP:0001973)1.89493803
81Gastrointestinal inflammation (HP:0004386)1.87843110
82Dysmetric saccades (HP:0000641)1.87675053
83Leukocytosis (HP:0001974)1.87535059
84Widely spaced teeth (HP:0000687)1.84959190
85Tubulointerstitial fibrosis (HP:0005576)1.84643864
86Abnormality of the prostate (HP:0008775)1.84016879
87Increased CSF protein (HP:0002922)1.83800452
88Abnormality of proline metabolism (HP:0010907)1.83142424
89Hydroxyprolinuria (HP:0003080)1.83142424
90Abnormality of T cell physiology (HP:0011840)1.82945613
91Stomach cancer (HP:0012126)1.82441690
92Pancreatic cysts (HP:0001737)1.78121105
93Severe combined immunodeficiency (HP:0004430)1.77337104
94Mediastinal lymphadenopathy (HP:0100721)1.76966367
95Absent speech (HP:0001344)1.74377482
96Progressive visual loss (HP:0000529)1.73260741
97Acne (HP:0001061)1.73192503
98Chest pain (HP:0100749)1.73147943
99Increased corneal curvature (HP:0100692)1.72927965
100Keratoconus (HP:0000563)1.72927965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.54719246
2MAP2K62.29568304
3TYK22.21342983
4TAOK32.20037611
5PIK3CG2.16249021
6MAP3K142.14338889
7ADRBK21.98641716
8MAP4K11.97901157
9JAK11.92459221
10NLK1.91436913
11AKT31.91194492
12ERN11.89144135
13TEC1.78963283
14TXK1.77366638
15TGFBR21.75530455
16IRAK11.73257699
17TNK21.72812390
18KIT1.68608254
19TRPM71.65074847
20RIPK41.60219739
21FGFR31.57905948
22EPHA31.55640653
23IKBKB1.45250267
24IKBKE1.44764999
25MAP4K21.44546114
26INSRR1.42021355
27ACVR1B1.41938916
28ITK1.37846979
29JAK31.32586383
30BLK1.28281343
31FER1.27488028
32BTK1.25129159
33EIF2AK31.22252263
34MAP3K21.15208949
35SYK1.09390154
36PTK2B1.07668393
37CSF1R1.04176925
38MAPKAPK31.00615946
39HCK0.97421779
40TBK10.94122009
41MAPK70.93968266
42GRK10.92062737
43MAP3K30.88497384
44LATS10.88321077
45MAPK110.87953069
46ADRBK10.86467732
47CAMKK20.86420158
48JAK20.85656225
49BMPR1B0.85034881
50LCK0.84940563
51MAP3K70.84556031
52PDK10.83895844
53PRKD20.83720938
54MARK30.83362622
55CSK0.82881622
56NUAK10.81659427
57FES0.80560994
58LYN0.80180036
59ZAP700.79670006
60STK100.79558880
61GRK60.77546311
62HIPK20.76962596
63YES10.74941408
64FGFR40.74128504
65BMPR20.73753890
66IRAK40.72502297
67PRKAA20.72439176
68SGK20.71639326
69EPHB10.71505719
70STK380.71298330
71MELK0.71230379
72MAP3K130.71228653
73CHUK0.69436396
74MAP2K30.67940160
75PRKCQ0.65749893
76OXSR10.65518253
77CDC42BPA0.62076608
78MAPK130.59905385
79NEK90.59820404
80PDPK10.54911801
81MST40.53718009
82PRKCH0.51668481
83PRKCE0.49275725
84STK30.48945362
85CDK120.47972848
86ABL10.47092601
87SGK30.45511342
88STK38L0.44927068
89DAPK20.42933951
90MAP2K20.39980002
91MAPKAPK20.38963550
92PDGFRB0.38128763
93MAP3K10.35752099
94RPS6KB10.35211816
95EEF2K0.34356130
96MAPK30.33681513
97IGF1R0.33502257
98NTRK30.32174230
99MATK0.31741185
100MYLK0.31383776

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24114131
2Graft-versus-host disease_Homo sapiens_hsa053322.14486774
3ABC transporters_Homo sapiens_hsa020102.09837896
4Primary immunodeficiency_Homo sapiens_hsa053401.96509685
5Allograft rejection_Homo sapiens_hsa053301.87427797
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.84596809
7Autoimmune thyroid disease_Homo sapiens_hsa053201.77729717
8Staphylococcus aureus infection_Homo sapiens_hsa051501.75000874
9Type I diabetes mellitus_Homo sapiens_hsa049401.70570720
10Jak-STAT signaling pathway_Homo sapiens_hsa046301.66552437
11Osteoclast differentiation_Homo sapiens_hsa043801.51968327
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.51082618
13Tryptophan metabolism_Homo sapiens_hsa003801.49525351
14Leishmaniasis_Homo sapiens_hsa051401.43978962
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.43936802
16Hematopoietic cell lineage_Homo sapiens_hsa046401.43191748
17Dorso-ventral axis formation_Homo sapiens_hsa043201.40395983
18Sphingolipid metabolism_Homo sapiens_hsa006001.38680137
19Asthma_Homo sapiens_hsa053101.38171061
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.33635405
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.33579899
22Measles_Homo sapiens_hsa051621.33168812
23B cell receptor signaling pathway_Homo sapiens_hsa046621.32110379
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30276035
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28319833
26Platelet activation_Homo sapiens_hsa046111.27392338
27Other glycan degradation_Homo sapiens_hsa005111.26559307
28Fatty acid biosynthesis_Homo sapiens_hsa000611.24655412
29Butanoate metabolism_Homo sapiens_hsa006501.23228503
30T cell receptor signaling pathway_Homo sapiens_hsa046601.20621806
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19299338
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19041832
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18337155
34Complement and coagulation cascades_Homo sapiens_hsa046101.13756258
35Toxoplasmosis_Homo sapiens_hsa051451.12884431
36TNF signaling pathway_Homo sapiens_hsa046681.12327560
37Glycerolipid metabolism_Homo sapiens_hsa005611.05335437
38Lysosome_Homo sapiens_hsa041421.04312105
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.03419020
40Antigen processing and presentation_Homo sapiens_hsa046121.02127506
41Tuberculosis_Homo sapiens_hsa051521.01762985
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98526575
43Herpes simplex infection_Homo sapiens_hsa051680.98355129
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97982288
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97891754
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97784241
47Influenza A_Homo sapiens_hsa051640.92893485
48Linoleic acid metabolism_Homo sapiens_hsa005910.92874515
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92312175
50Hepatitis C_Homo sapiens_hsa051600.91495811
51Ether lipid metabolism_Homo sapiens_hsa005650.91339050
52Chemical carcinogenesis_Homo sapiens_hsa052040.86928381
53Insulin resistance_Homo sapiens_hsa049310.86462792
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86257545
55Retinol metabolism_Homo sapiens_hsa008300.84245362
56African trypanosomiasis_Homo sapiens_hsa051430.83368399
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80775930
58Caffeine metabolism_Homo sapiens_hsa002320.80314182
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80039162
60Acute myeloid leukemia_Homo sapiens_hsa052210.79525040
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75765795
62Lysine degradation_Homo sapiens_hsa003100.74581363
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73645695
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72305944
65Hepatitis B_Homo sapiens_hsa051610.70932428
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.70885233
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70061194
68Prolactin signaling pathway_Homo sapiens_hsa049170.69421743
69Pertussis_Homo sapiens_hsa051330.68999201
70Arachidonic acid metabolism_Homo sapiens_hsa005900.68921952
71Pancreatic cancer_Homo sapiens_hsa052120.68415141
72Histidine metabolism_Homo sapiens_hsa003400.67524421
73FoxO signaling pathway_Homo sapiens_hsa040680.67122089
74Rheumatoid arthritis_Homo sapiens_hsa053230.67097723
75Malaria_Homo sapiens_hsa051440.66897884
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65243574
77Chemokine signaling pathway_Homo sapiens_hsa040620.65038769
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63890204
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63717257
80Circadian rhythm_Homo sapiens_hsa047100.63653712
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63375604
82Ovarian steroidogenesis_Homo sapiens_hsa049130.58455541
83Inositol phosphate metabolism_Homo sapiens_hsa005620.57830059
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57672816
85Olfactory transduction_Homo sapiens_hsa047400.57575162
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57491233
87Legionellosis_Homo sapiens_hsa051340.57063131
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54737975
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54446900
90mTOR signaling pathway_Homo sapiens_hsa041500.54104460
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53950690
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52884793
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51949698
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.51894115
95Salivary secretion_Homo sapiens_hsa049700.50223213
96Starch and sucrose metabolism_Homo sapiens_hsa005000.50135131
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.49617412
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.48922524
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48183335
100Sulfur metabolism_Homo sapiens_hsa009200.47206496

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