TRIM40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)8.18472069
2negative regulation of macroautophagy (GO:0016242)7.90401219
3regulation of autophagic vacuole assembly (GO:2000785)7.26061767
4intestinal absorption (GO:0050892)7.17474575
5intestinal cholesterol absorption (GO:0030299)6.84824217
6cytidine deamination (GO:0009972)6.75596713
7cytidine metabolic process (GO:0046087)6.75596713
8cytidine catabolic process (GO:0006216)6.75596713
9sulfate transmembrane transport (GO:1902358)6.39859136
10neutrophil activation involved in immune response (GO:0002283)6.29202823
11negative regulation of keratinocyte proliferation (GO:0010839)5.98682360
12angiotensin maturation (GO:0002003)5.94538896
13purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.91244714
143-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.91244714
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.83073734
16regulation of vacuole organization (GO:0044088)5.82385481
17negative regulation of T cell differentiation in thymus (GO:0033085)5.80186168
18negative regulation of organelle assembly (GO:1902116)5.74155892
19negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)5.62391850
20positive regulation of T cell differentiation in thymus (GO:0033089)5.57142193
21regulation of viral release from host cell (GO:1902186)5.51325482
22maintenance of gastrointestinal epithelium (GO:0030277)5.47095562
23sulfate transport (GO:0008272)5.25572056
24bile acid and bile salt transport (GO:0015721)5.14005360
25regulation of platelet aggregation (GO:0090330)5.09098497
26keratinocyte development (GO:0003334)5.00966203
27negative regulation of norepinephrine secretion (GO:0010700)4.99772602
28regulation of platelet activation (GO:0010543)4.98136914
29adenosine receptor signaling pathway (GO:0001973)4.92407571
30pyrimidine ribonucleoside catabolic process (GO:0046133)4.88054182
31hemidesmosome assembly (GO:0031581)4.85826871
32low-density lipoprotein particle remodeling (GO:0034374)4.81906403
33regulation of integrin-mediated signaling pathway (GO:2001044)4.80418443
34chondrocyte proliferation (GO:0035988)4.77676949
35regulation of vitamin metabolic process (GO:0030656)4.64996239
36actin filament depolymerization (GO:0030042)4.55747054
37intestinal epithelial cell development (GO:0060576)4.55367371
38blood coagulation, intrinsic pathway (GO:0007597)4.51470417
39leukocyte migration involved in inflammatory response (GO:0002523)4.41081703
40G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.40206422
41platelet aggregation (GO:0070527)4.38149244
42alkaloid metabolic process (GO:0009820)4.38068732
43regulation of lipoprotein metabolic process (GO:0050746)4.36827316
44response to hepatocyte growth factor (GO:0035728)4.35250889
45cellular response to hepatocyte growth factor stimulus (GO:0035729)4.35250889
46sulfur compound transport (GO:0072348)4.34988859
47negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.32642118
48regulation of integrin activation (GO:0033623)4.32237391
49negative regulation of protein tyrosine kinase activity (GO:0061099)4.28263144
50negative regulation of platelet activation (GO:0010544)4.23079878
51negative regulation of homotypic cell-cell adhesion (GO:0034111)4.22976620
52regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.21877782
53epithelial structure maintenance (GO:0010669)4.18551463
54vitamin A metabolic process (GO:0006776)4.16723629
55regulation of RIG-I signaling pathway (GO:0039535)4.08561981
56UDP-N-acetylglucosamine metabolic process (GO:0006047)4.08484630
57positive regulation of endothelial cell differentiation (GO:0045603)4.08224943
58thyroid hormone metabolic process (GO:0042403)4.04866240
59positive regulation of epidermal cell differentiation (GO:0045606)3.97530421
60epithelial cell-cell adhesion (GO:0090136)3.95682440
61virion attachment to host cell (GO:0019062)3.92651989
62adhesion of symbiont to host cell (GO:0044650)3.92651989
63lipoxygenase pathway (GO:0019372)3.90624762
64positive regulation of systemic arterial blood pressure (GO:0003084)3.86914160
65digestive system process (GO:0022600)3.85590983
66regulation of Golgi to plasma membrane protein transport (GO:0042996)3.82509484
67regulation of bile acid biosynthetic process (GO:0070857)3.81627109
68neutrophil activation (GO:0042119)3.80614435
69phosphatidylcholine biosynthetic process (GO:0006656)3.78622284
70negative regulation of alpha-beta T cell differentiation (GO:0046639)3.76192513
71flavonoid metabolic process (GO:0009812)3.74214614
72positive regulation of receptor recycling (GO:0001921)3.71237281
73O-glycan processing (GO:0016266)3.70746408
74beta-amyloid metabolic process (GO:0050435)3.68034026
75nucleotide salvage (GO:0043173)3.67276240
76hydrogen peroxide catabolic process (GO:0042744)3.64923722
77positive regulation of Rho protein signal transduction (GO:0035025)3.63504427
78positive regulation of mast cell activation (GO:0033005)3.61888400
79modified amino acid transport (GO:0072337)3.61278057
80negative regulation of heart rate (GO:0010459)3.59989454
81cGMP-mediated signaling (GO:0019934)3.58362691
82angiogenesis involved in wound healing (GO:0060055)3.58212401
83platelet degranulation (GO:0002576)3.57268353
84high-density lipoprotein particle remodeling (GO:0034375)3.55664142
85cyclooxygenase pathway (GO:0019371)3.53805537
86negative regulation of protein localization to cell surface (GO:2000009)3.53438952
87purinergic nucleotide receptor signaling pathway (GO:0035590)3.52305205
88antibacterial humoral response (GO:0019731)3.52174606
89regulation of keratinocyte proliferation (GO:0010837)3.51850385
90sulfur amino acid catabolic process (GO:0000098)3.51120133
91regulation of macrophage derived foam cell differentiation (GO:0010743)3.49699624
92peptide catabolic process (GO:0043171)3.49554124
93drug catabolic process (GO:0042737)3.47775755
94antimicrobial humoral response (GO:0019730)3.46492065
95positive regulation of epidermis development (GO:0045684)3.45288333
96regulation of water loss via skin (GO:0033561)3.43120367
97hydrogen peroxide metabolic process (GO:0042743)3.39770907
98activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.39610938
99regulation of cholesterol homeostasis (GO:2000188)3.38161097
100bone resorption (GO:0045453)3.37078216
101transcytosis (GO:0045056)3.36286080
102estrogen biosynthetic process (GO:0006703)3.36114727
103regulation of guanylate cyclase activity (GO:0031282)3.35788364
104regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.34774381
105calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.34654316
106response to hydroperoxide (GO:0033194)3.33982510
107granulocyte activation (GO:0036230)3.31649013
108megakaryocyte development (GO:0035855)3.31052182
109somite development (GO:0061053)3.31028378
110reverse cholesterol transport (GO:0043691)3.30185035
111nucleoside diphosphate biosynthetic process (GO:0009133)3.29342391
112hepatocyte apoptotic process (GO:0097284)3.28260928
113negative regulation of receptor activity (GO:2000272)3.25334189
114platelet activation (GO:0030168)3.24037740
115positive regulation of hemostasis (GO:1900048)3.23287622
116positive regulation of blood coagulation (GO:0030194)3.23287622
117negative regulation of thymocyte apoptotic process (GO:0070244)3.20740339
118homotypic cell-cell adhesion (GO:0034109)3.20228268
119pyrimidine nucleoside catabolic process (GO:0046135)3.19470887
120positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.18084764
121negative regulation of T-helper cell differentiation (GO:0045623)3.17854831
122negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17854831
123establishment of skin barrier (GO:0061436)3.16390970
124platelet formation (GO:0030220)3.15737191
125mitotic G2 DNA damage checkpoint (GO:0007095)3.14992908
126G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.14990728
127negative regulation of protein localization to plasma membrane (GO:1903077)3.13587203
128regulation of regulatory T cell differentiation (GO:0045589)3.11894224
129adhesion of symbiont to host (GO:0044406)3.11849833
130positive regulation of macrophage differentiation (GO:0045651)3.11845052
131phospholipid homeostasis (GO:0055091)3.11312929
132regulation of norepinephrine secretion (GO:0014061)3.11202814
133glucose 6-phosphate metabolic process (GO:0051156)3.09520050
134negative regulation of heart contraction (GO:0045822)3.08436936
135triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.08119776
136phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.07577972
137fusion of sperm to egg plasma membrane (GO:0007342)3.06704746
138nucleoside bisphosphate biosynthetic process (GO:0033866)3.05435974
139purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.05435974
140ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.05435974
141regulation of female receptivity (GO:0045924)3.02894550
142fucose catabolic process (GO:0019317)3.02549736
143L-fucose metabolic process (GO:0042354)3.02549736
144L-fucose catabolic process (GO:0042355)3.02549736
145regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.02407826
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02394132
147negative regulation of appetite (GO:0032099)3.02261566
148negative regulation of response to food (GO:0032096)3.02261566
149negative regulation of catecholamine secretion (GO:0033604)3.01556058
150regulation of homotypic cell-cell adhesion (GO:0034110)2.98163166
151regulation of hemostasis (GO:1900046)2.97830743
152regulation of blood coagulation (GO:0030193)2.97830743
153positive regulation of lipoprotein lipase activity (GO:0051006)2.96198141
154positive regulation of triglyceride lipase activity (GO:0061365)2.96198141
155positive regulation of coagulation (GO:0050820)2.94886957
156regulation of receptor recycling (GO:0001919)2.93544665
157purine nucleotide salvage (GO:0032261)2.93115991
158positive regulation of guanylate cyclase activity (GO:0031284)2.92932403
159neurotransmitter biosynthetic process (GO:0042136)2.92486027
160endothelium development (GO:0003158)2.91999959
161vitamin transmembrane transport (GO:0035461)2.91804218
162thyroid hormone generation (GO:0006590)2.91697157
163phospholipid efflux (GO:0033700)2.90866842
164purinergic receptor signaling pathway (GO:0035587)2.90803380
165positive regulation of cAMP-mediated signaling (GO:0043950)2.90169083
166ventricular cardiac muscle cell action potential (GO:0086005)2.89077456
167autophagic vacuole fusion (GO:0000046)2.88364920
168innate immune response in mucosa (GO:0002227)2.88361891
169cholesterol homeostasis (GO:0042632)2.88251183
170extracellular fibril organization (GO:0043206)2.87789838
171sterol homeostasis (GO:0055092)2.86961233
172regulation of T cell differentiation in thymus (GO:0033081)2.86403652
173negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85585859
174regulation of endothelial cell differentiation (GO:0045601)2.85142919
175negative regulation of neural precursor cell proliferation (GO:2000178)2.83345425
176regulation of T-helper 1 cell differentiation (GO:0045625)2.81823455
177dendritic cell chemotaxis (GO:0002407)2.81651830
178negative regulation of blood coagulation (GO:0030195)2.78483642
179negative regulation of hemostasis (GO:1900047)2.78483642
180positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.77816130
181regulation of coagulation (GO:0050818)2.73146005
182mitochondrial calcium ion transport (GO:0006851)2.72737928
183fatty acid elongation (GO:0030497)2.71935344
184female mating behavior (GO:0060180)2.71834331
185fibril organization (GO:0097435)2.70308813
186vesicle targeting (GO:0006903)2.68892882
187* protein neddylation (GO:0045116)2.68892663
188negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.68583949
189regulation of memory T cell differentiation (GO:0043380)2.67848967
190positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.66992782
191negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.65637255
192androgen biosynthetic process (GO:0006702)2.61655682
193regulation of T-helper 2 cell differentiation (GO:0045628)2.61342471
194polyamine biosynthetic process (GO:0006596)2.60926169
195termination of G-protein coupled receptor signaling pathway (GO:0038032)2.59117641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human4.44780535
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.04955961
3SCL_19346495_ChIP-Seq_HPC-7_Human3.49603947
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.25033400
5SOX2_27498859_Chip-Seq_STOMACH_Mouse2.99248423
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.93354011
7GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.73971533
8SOX2_20726797_ChIP-Seq_SW620_Human2.71670939
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65351475
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64231473
11VDR_22108803_ChIP-Seq_LS180_Human2.49737425
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.48394324
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.47402228
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44794537
15* GATA4_25053715_ChIP-Seq_YYC3_Human2.42680493
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.38407692
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.33472915
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.29741402
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25455523
20GATA1_19941827_ChIP-Seq_MEL_Mouse2.21518816
21GATA6_25053715_ChIP-Seq_YYC3_Human2.15020751
22LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.14332007
23* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.12905542
24ESR1_20079471_ChIP-ChIP_T-47D_Human2.07465023
25PPAR_26484153_Chip-Seq_NCI-H1993_Human2.07359228
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.02452899
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01957812
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.01201846
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01060522
30TP63_17297297_ChIP-ChIP_HaCaT_Human10.3444472
31GATA1_22025678_ChIP-Seq_K562_Human1.98500421
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97916157
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.94393296
34SPI1_23127762_ChIP-Seq_K562_Human1.93394222
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92312327
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91928362
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86777800
38KLF5_25053715_ChIP-Seq_YYC3_Human1.86034182
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85330015
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.77570939
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.77419218
42* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.71911266
43BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.71303450
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.71026184
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.68827170
46HTT_18923047_ChIP-ChIP_STHdh_Human1.67863432
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.65965844
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65143430
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.63819575
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.63780403
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63758347
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63741050
53ELK4_26923725_Chip-Seq_MESODERM_Mouse1.57168930
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.57080551
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56957505
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.52581093
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.48232190
58RACK7_27058665_Chip-Seq_MCF-7_Human1.48024112
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46731809
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44809982
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43994815
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.41971395
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40483386
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.40077309
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39596859
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38471366
67GATA1_19941827_ChIP-Seq_MEL86_Mouse1.37960667
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35887712
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35378679
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.32549325
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31843279
72AR_21909140_ChIP-Seq_LNCAP_Human1.31642533
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30455999
74EGR1_19032775_ChIP-ChIP_M12_Human1.30332718
75* RUNX1_22412390_ChIP-Seq_EML_Mouse1.30277163
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.29762676
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28710366
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27862336
79EZH2_22144423_ChIP-Seq_EOC_Human1.23850702
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23422496
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23263989
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22034958
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21125268
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21125268
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20556072
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20023219
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19493041
88* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18589385
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17722018
90ATF3_27146783_Chip-Seq_COLON_Human1.15511749
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14810050
92SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14736473
93SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14736473
94RUNX_20019798_ChIP-Seq_JUKART_Human1.14066585
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13640091
96GATA2_19941826_ChIP-Seq_K562_Human1.12713903
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12634930
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11669759
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11650792
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11412834
101KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.11077599
102IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11025406
103FOXA1_25552417_ChIP-Seq_VCAP_Human1.10213488
104RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09900055
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08851365
106SALL4_22934838_ChIP-ChIP_CD34+_Human1.08199152
107TP63_22573176_ChIP-Seq_HFKS_Human1.05672650
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04848857
109RXR_22108803_ChIP-Seq_LS180_Human1.03971296
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03505498
111CLOCK_20551151_ChIP-Seq_293T_Human1.03229508
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01404366
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00339493
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.99892261
115STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99453016
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99291199
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98096554
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94241406
119NANOG_20526341_ChIP-Seq_ESCs_Human0.93125812
120* HNF4A_19822575_ChIP-Seq_HepG2_Human0.92528438
121ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92115146
122BCOR_27268052_Chip-Seq_Bcells_Human0.91771519
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90085893
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.89680042
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88619632
126POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87857821
127TAF2_19829295_ChIP-Seq_ESCs_Human0.86997042
128STAT1_20625510_ChIP-Seq_HELA_Human0.86963496
129NANOG_18692474_ChIP-Seq_MEFs_Mouse0.86569465
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86030050
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85742331
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85279398
133ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85190735
134OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84466237
135JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.84009168
136KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83470950
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82716280
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81922177
139LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81740502
140GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81725965
141CDX2_22108803_ChIP-Seq_LS180_Human0.81719654
142GBX2_23144817_ChIP-Seq_PC3_Human0.81688802
143BCAT_22108803_ChIP-Seq_LS180_Human0.81549324
144CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81152126
145CEBPB_22108803_ChIP-Seq_LS180_Human0.80478177
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.80289561
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80185455
148NCOR1_26117541_ChIP-Seq_K562_Human0.79979383
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79578055
150NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79114025
151HIF1A_21447827_ChIP-Seq_MCF-7_Human0.78557931
152OCT1_27270436_Chip-Seq_PROSTATE_Human0.78310979
153BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77841819
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77385128
155GATA3_21878914_ChIP-Seq_MCF-7_Human0.76770783
156* FOXA2_19822575_ChIP-Seq_HepG2_Human0.76382987
157GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76223119
158GATA1_19941826_ChIP-Seq_K562_Human0.76101217
159CREB1_26743006_Chip-Seq_LNCaP_Human0.72402304
160P63_26484246_Chip-Seq_KERATINOCYTES_Human0.71304290
161SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.70032142
162DROSHA_22980978_ChIP-Seq_HELA_Human0.69892747
163P68_20966046_ChIP-Seq_HELA_Human0.69607523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle8.50046844
2MP0005464_abnormal_platelet_physiology8.18224195
3MP0003283_abnormal_digestive_organ6.60423216
4MP0005360_urolithiasis5.70271297
5MP0008004_abnormal_stomach_pH4.61807182
6MP0001666_abnormal_nutrient_absorption4.50742168
7MP0000462_abnormal_digestive_system4.09432103
8MP0003724_increased_susceptibility_to3.97962633
9MP0004264_abnormal_extraembryonic_tissu3.59424769
10MP0003315_abnormal_perineum_morphology3.25054542
11MP0000465_gastrointestinal_hemorrhage3.12947234
12MP0009053_abnormal_anal_canal2.91530186
13MP0002234_abnormal_pharynx_morphology2.76545399
14MP0003866_abnormal_defecation2.75609717
15MP0005085_abnormal_gallbladder_physiolo2.64125989
16MP0000537_abnormal_urethra_morphology2.60330986
17MP0004510_myositis2.48800659
18MP0009697_abnormal_copulation2.29170730
19MP0001835_abnormal_antigen_presentation2.26683727
20MP0000230_abnormal_systemic_arterial2.23923493
21MP0003303_peritoneal_inflammation2.22460674
22MP0003252_abnormal_bile_duct2.16407585
23MP0000343_altered_response_to2.15875491
24MP0004019_abnormal_vitamin_homeostasis2.04783333
25MP0009840_abnormal_foam_cell2.00931336
26MP0010678_abnormal_skin_adnexa1.87272277
27MP0005381_digestive/alimentary_phenotyp1.85093734
28MP0002876_abnormal_thyroid_physiology1.82646478
29MP0002139_abnormal_hepatobiliary_system1.80323657
30MP0008775_abnormal_heart_ventricle1.79744578
31MP0000538_abnormal_urinary_bladder1.79619278
32MP0010155_abnormal_intestine_physiology1.78077848
33MP0000477_abnormal_intestine_morphology1.74073683
34MP0005671_abnormal_response_to1.69484226
35MP0003566_abnormal_cell_adhesion1.68969833
36MP0002796_impaired_skin_barrier1.66902542
37MP0005083_abnormal_biliary_tract1.66538272
38MP0008875_abnormal_xenobiotic_pharmacok1.63782799
39MP0003705_abnormal_hypodermis_morpholog1.61537518
40MP0005409_darkened_coat_color1.59822114
41MP0005084_abnormal_gallbladder_morpholo1.59720963
42MP0005451_abnormal_body_composition1.56133683
43MP0004084_abnormal_cardiac_muscle1.54425787
44MP0004947_skin_inflammation1.50700654
45MP0001663_abnormal_digestive_system1.48949111
46MP0003828_pulmonary_edema1.48768556
47MP0003879_abnormal_hair_cell1.47684970
48MP0002822_catalepsy1.45972490
49MP0003183_abnormal_peptide_metabolism1.44452305
50MP0001879_abnormal_lymphatic_vessel1.44057625
51MP0003638_abnormal_response/metabolism_1.43864643
52MP0005000_abnormal_immune_tolerance1.43623699
53MP0000249_abnormal_blood_vessel1.42233256
54MP0010329_abnormal_lipoprotein_level1.41809707
55MP0001849_ear_inflammation1.41614788
56MP0005365_abnormal_bile_salt1.37722788
57MP0002098_abnormal_vibrissa_morphology1.33499047
58MP0001664_abnormal_digestion1.32210674
59MP0003436_decreased_susceptibility_to1.30013878
60MP0003453_abnormal_keratinocyte_physiol1.28345576
61MP0009643_abnormal_urine_homeostasis1.26681966
62MP0001533_abnormal_skeleton_physiology1.26274454
63MP0005310_abnormal_salivary_gland1.24783389
64MP0001765_abnormal_ion_homeostasis1.22982242
65MP0003806_abnormal_nucleotide_metabolis1.22830065
66MP0005410_abnormal_fertilization1.20349782
67MP0005023_abnormal_wound_healing1.16323276
68MP0003878_abnormal_ear_physiology1.13086299
69MP0005377_hearing/vestibular/ear_phenot1.13086299
70MP0001873_stomach_inflammation1.12640269
71MP0004782_abnormal_surfactant_physiolog1.12197944
72MP0001851_eye_inflammation1.10470143
73MP0001800_abnormal_humoral_immune1.10364961
74MP0002736_abnormal_nociception_after1.09482613
75MP0002733_abnormal_thermal_nociception1.08958041
76MP0000490_abnormal_crypts_of1.08662123
77MP0006054_spinal_hemorrhage1.08331152
78MP0002723_abnormal_immune_serum1.08042116
79MP0006276_abnormal_autonomic_nervous1.07990040
80MP0002998_abnormal_bone_remodeling1.07762048
81MP0005387_immune_system_phenotype1.07662833
82MP0001790_abnormal_immune_system1.07662833
83MP0009763_increased_sensitivity_to1.05444258
84MP0002398_abnormal_bone_marrow1.05278979
85MP0005165_increased_susceptibility_to1.04520341
86MP0005025_abnormal_response_to1.03915474
87MP0002452_abnormal_antigen_presenting1.03036426
88MP0009642_abnormal_blood_homeostasis1.02679496
89MP0000858_altered_metastatic_potential1.02134663
90MP0005501_abnormal_skin_physiology1.01743153
91MP0001216_abnormal_epidermal_layer1.00920105
92MP0009764_decreased_sensitivity_to1.00559556
93MP0010352_gastrointestinal_tract_polyps1.00483487
94MP0004036_abnormal_muscle_relaxation1.00416254
95MP0005666_abnormal_adipose_tissue0.98629828
96MP0004215_abnormal_myocardial_fiber0.98214400
97MP0002254_reproductive_system_inflammat0.96793494
98MP0004043_abnormal_pH_regulation0.96567178
99MP0005397_hematopoietic_system_phenotyp0.96346439
100MP0001545_abnormal_hematopoietic_system0.96346439
101MP0005636_abnormal_mineral_homeostasis0.95327896
102MP0002132_abnormal_respiratory_system0.94841133
103MP0006138_congestive_heart_failure0.94353486
104MP0004147_increased_porphyrin_level0.94045097
105MP0003045_fibrosis0.93313664
106MP0000516_abnormal_urinary_system0.91131261
107MP0005367_renal/urinary_system_phenotyp0.91131261
108MP0005187_abnormal_penis_morphology0.90201514
109MP0005167_abnormal_blood-brain_barrier0.89669618
110MP0009333_abnormal_splenocyte_physiolog0.89062406
111MP0001756_abnormal_urination0.87524818
112MP0001501_abnormal_sleep_pattern0.87048074
113MP0004130_abnormal_muscle_cell0.86702087
114MP0000685_abnormal_immune_system0.86392636
115MP0000613_abnormal_salivary_gland0.85213397
116MP0000377_abnormal_hair_follicle0.84135293
117MP0001819_abnormal_immune_cell0.83692969
118MP0000467_abnormal_esophagus_morphology0.82720590
119MP0002429_abnormal_blood_cell0.82601216
120MP0005166_decreased_susceptibility_to0.82555778
121MP0002420_abnormal_adaptive_immunity0.82485666
122MP0005646_abnormal_pituitary_gland0.82272294
123MP0000762_abnormal_tongue_morphology0.81465717
124MP0004484_altered_response_of0.81398184
125MP0002419_abnormal_innate_immunity0.81202188
126MP0009780_abnormal_chondrocyte_physiolo0.80679558
127MP0002136_abnormal_kidney_physiology0.79171175
128MP0009785_altered_susceptibility_to0.76454723
129MP0003718_maternal_effect0.75309692
130MP0003937_abnormal_limbs/digits/tail_de0.74370026
131MP0003329_amyloid_beta_deposits0.72962589
132MP0000604_amyloidosis0.70361786
133MP0004272_abnormal_basement_membrane0.70222117
134MP0005332_abnormal_amino_acid0.69168850
135MP0005448_abnormal_energy_balance0.63280843
136MP0002060_abnormal_skin_morphology0.60879745
137MP0001881_abnormal_mammary_gland0.59661438
138MP0002118_abnormal_lipid_homeostasis0.58889507
139MP0000609_abnormal_liver_physiology0.56101372
140MP0000470_abnormal_stomach_morphology0.55592277
141MP0003300_gastrointestinal_ulcer0.55544281
142MP0003938_abnormal_ear_development0.53066284
143MP0002896_abnormal_bone_mineralization0.51917099
144MP0000579_abnormal_nail_morphology0.51565409
145MP0001191_abnormal_skin_condition0.49727411
146MP0000163_abnormal_cartilage_morphology0.49051991
147MP0004185_abnormal_adipocyte_glucose0.48859199
148MP0008872_abnormal_physiological_respon0.48472466
149MP0010771_integument_phenotype0.47238660
150MP0000627_abnormal_mammary_gland0.46307072
151MP0009931_abnormal_skin_appearance0.43142267
152MP0003075_altered_response_to0.43027231
153MP0004270_analgesia0.42814578
154MP0003385_abnormal_body_wall0.42177375
155MP0004858_abnormal_nervous_system0.41942178
156MP0001845_abnormal_inflammatory_respons0.40479061
157MP0005058_abnormal_lysosome_morphology0.40290986
158MP0002148_abnormal_hypersensitivity_rea0.38938560
159MP0002932_abnormal_joint_morphology0.37242762

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.83893780
2Petechiae (HP:0000967)9.26627447
3Menorrhagia (HP:0000132)8.99346073
4Increased mean platelet volume (HP:0011877)8.79635514
5Abnormal platelet volume (HP:0011876)8.25636765
6Purpura (HP:0000979)7.72422160
7Epistaxis (HP:0000421)6.92781360
8Gingival bleeding (HP:0000225)6.48624103
9Posterior subcapsular cataract (HP:0007787)6.37939398
10Flat acetabular roof (HP:0003180)5.77682657
11Abnormality of the 1st metacarpal (HP:0010009)5.74221328
12Hyperlipoproteinemia (HP:0010980)5.49051705
13Abnormality of the distal phalanx of the thumb (HP:0009617)5.40094693
14Abnormal platelet function (HP:0011869)5.39170940
15Impaired platelet aggregation (HP:0003540)5.39170940
16Cupped ribs (HP:0000887)5.36388091
17Symphalangism affecting the phalanges of the hand (HP:0009773)5.16782164
18Fragile nails (HP:0001808)4.94089949
19Ileus (HP:0002595)4.74911183
20Neonatal short-limb short stature (HP:0008921)4.74460537
21Flat capital femoral epiphysis (HP:0003370)4.72320166
22Right ventricular cardiomyopathy (HP:0011663)4.62976324
23Spontaneous hematomas (HP:0007420)4.60264154
24Poikilocytosis (HP:0004447)4.54421648
25Abnormality of carpal bone ossification (HP:0006257)4.23795852
26Dyschromatopsia (HP:0007641)4.12150663
27Abnormality of the proximal phalanges of the hand (HP:0009834)4.04876420
28Irregular epiphyses (HP:0010582)4.03056240
29Abnormal pupillary function (HP:0007686)4.02079985
30Short phalanx of the thumb (HP:0009660)3.96926442
31Abnormality of the 2nd finger (HP:0004100)3.96780231
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.83286614
33Flattened epiphyses (HP:0003071)3.83150248
34Subcapsular cataract (HP:0000523)3.74542030
35Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.71252326
36Short middle phalanx of finger (HP:0005819)3.70021612
37Abnormal tarsal ossification (HP:0008369)3.66196329
38Onycholysis (HP:0001806)3.62103010
39Abnormality of proline metabolism (HP:0010907)3.57277821
40Hydroxyprolinuria (HP:0003080)3.57277821
41Spinal cord compression (HP:0002176)3.53911587
42Breech presentation (HP:0001623)3.53900422
43Abnormality of the phalanges of the hallux (HP:0010057)3.51317198
44Vertebral clefting (HP:0008428)3.51223502
45Abnormal cartilage morphology (HP:0002763)3.42359994
46Abnormality of the common coagulation pathway (HP:0010990)3.39957365
47Conjunctival telangiectasia (HP:0000524)3.37852903
48Breast hypoplasia (HP:0003187)3.36137208
49Abnormality of the middle phalanges of the toes (HP:0010183)3.30879300
50Pustule (HP:0200039)3.29265840
51Xanthomatosis (HP:0000991)3.21029112
52Short hallux (HP:0010109)3.18583352
53Abdominal distention (HP:0003270)3.17989386
54Woolly hair (HP:0002224)3.14791878
55Abnormal hand bone ossification (HP:0010660)3.12578852
56Abnormal ossification of hand bones (HP:0005921)3.11906281
57Bruising susceptibility (HP:0000978)3.11822243
58Milia (HP:0001056)3.10754826
59Abnormality of the vasculature of the conjunctiva (HP:0008054)3.03221909
60Aplasia/hypoplasia of the femur (HP:0005613)3.02236366
61Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.01793782
62Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.98266545
63Vertebral hypoplasia (HP:0008417)2.98266545
64Paralysis (HP:0003470)2.96194319
65Absent phalangeal crease (HP:0006109)2.94805783
66Large earlobe (HP:0009748)2.92927094
67Aplasia/Hypoplasia of the hallux (HP:0008362)2.91921591
68Upper limb muscle weakness (HP:0003484)2.88323238
69Abnormal auditory evoked potentials (HP:0006958)2.87697028
70Joint swelling (HP:0001386)2.86360622
71Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.82012487
72Ridged nail (HP:0001807)2.79402390
73Nausea (HP:0002018)2.79393839
74Abnormal vertebral ossification (HP:0100569)2.77786229
75Hypoplastic ilia (HP:0000946)2.76131778
76Chronic diarrhea (HP:0002028)2.74905601
77Atrophic scars (HP:0001075)2.73561106
78Abnormality of the epiphysis of the femoral head (HP:0010574)2.65658480
79Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.65556016
80Eczematoid dermatitis (HP:0000976)2.64089624
81Conjugated hyperbilirubinemia (HP:0002908)2.62880666
82Joint hemorrhage (HP:0005261)2.61664858
83Abnormality of macrophages (HP:0004311)2.60640759
84Hoarse voice (HP:0001609)2.60399081
85Abnormality of the heme biosynthetic pathway (HP:0010472)2.56665958
86Cone-rod dystrophy (HP:0000548)2.55975791
87Lumbar hyperlordosis (HP:0002938)2.55003194
88Increased density of long bones (HP:0006392)2.51227765
89Shawl scrotum (HP:0000049)2.50727577
90Abnormal foot bone ossification (HP:0010675)2.50696590
91Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.45758989
92Malnutrition (HP:0004395)2.44424368
93Abnormality of femoral epiphyses (HP:0006499)2.43185418
94Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.43185418
95Short tibia (HP:0005736)2.43014026
96Decreased central vision (HP:0007663)2.42340387
97Tracheal stenosis (HP:0002777)2.41020696
98Abnormal finger flexion creases (HP:0006143)2.40135061
99Pterygium (HP:0001059)2.38828646
100Increased IgM level (HP:0003496)2.38469987
101Hyperglycinuria (HP:0003108)2.38224462
102Abnormality of the femoral head (HP:0003368)2.37256374
103Tongue fasciculations (HP:0001308)2.35287242
104Relative macrocephaly (HP:0004482)2.34634083
105Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33021038
106Goiter (HP:0000853)2.32840413
107Metabolic alkalosis (HP:0200114)2.31507801
108Short humerus (HP:0005792)2.30822241
109Plantar hyperkeratosis (HP:0007556)2.30255425
110Flared iliac wings (HP:0002869)2.26116822
111Hepatosplenomegaly (HP:0001433)2.25935939
112Hip contracture (HP:0003273)2.25925105
113Abnormality of the middle phalanges of the hand (HP:0009833)2.25027704
114Muscle fibrillation (HP:0010546)2.24904415
115Spontaneous abortion (HP:0005268)2.24146850
116Proximal placement of thumb (HP:0009623)2.24100926
117Generalized aminoaciduria (HP:0002909)2.20183605
118Polar cataract (HP:0010696)2.19990418
119Pili torti (HP:0003777)2.19945077
120Abnormality of iron homeostasis (HP:0011031)2.18775459
121Acanthocytosis (HP:0001927)2.18120248
122Coronal craniosynostosis (HP:0004440)2.16340963
123Visceral angiomatosis (HP:0100761)2.15269709
124Deviation of the thumb (HP:0009603)2.14785195
125Biliary tract neoplasm (HP:0100574)2.14266906
126Ventricular fibrillation (HP:0001663)2.13393389
127Autoimmune thrombocytopenia (HP:0001973)2.11647637
128Tinnitus (HP:0000360)2.10896178
129Aplasia/hypoplasia of the humerus (HP:0006507)2.09874965
130Hip dysplasia (HP:0001385)2.08951152
131Abnormality of lateral ventricle (HP:0030047)2.07755056
132Dehydration (HP:0001944)2.07489972
133Aplasia/Hypoplasia of the tibia (HP:0005772)2.07037354
134Hypobetalipoproteinemia (HP:0003563)2.04170013
135Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03179708
136Decreased circulating renin level (HP:0003351)2.02131505
137Polycythemia (HP:0001901)2.01739780
138Abnormality of transition element cation homeostasis (HP:0011030)2.00466165
139Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.98916799
140Hyperactive renin-angiotensin system (HP:0000841)1.96881701
141Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96454409
142Distal lower limb amyotrophy (HP:0008944)1.95887276
143Progressive sensorineural hearing impairment (HP:0000408)1.95585234
144Systemic lupus erythematosus (HP:0002725)1.94821679
145Hyperphosphaturia (HP:0003109)1.94228898
146Hemangiomatosis (HP:0007461)1.94061138
147Autoimmune hemolytic anemia (HP:0001890)1.93137664
148High anterior hairline (HP:0009890)1.91673624
149Ureteral stenosis (HP:0000071)1.91483189
150Congenital sensorineural hearing impairment (HP:0008527)1.88665064
151Encephalitis (HP:0002383)1.88625126
152Arterial thrombosis (HP:0004420)1.82186798
153Male infertility (HP:0003251)1.81418631
154Stomatitis (HP:0010280)1.77972439
155Hemorrhage of the eye (HP:0011885)1.77943691
156Papillary thyroid carcinoma (HP:0002895)1.77844550
157Myocardial infarction (HP:0001658)1.76648936
158Abnormality of the prostate (HP:0008775)1.71733650
159Polyphagia (HP:0002591)1.70987102
160Abnormality of renin-angiotensin system (HP:0000847)1.67967352
161Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67526426
162Hypophosphatemic rickets (HP:0004912)1.67520393
163Cerebral hemorrhage (HP:0001342)1.64705130
164Alkalosis (HP:0001948)1.63047519
165Testicular neoplasm (HP:0010788)1.62900773
166Vascular calcification (HP:0004934)1.61494109
167Growth hormone excess (HP:0000845)1.59363080
168Chest pain (HP:0100749)1.58914585
169Neoplasm of the rectum (HP:0100743)1.56622498
170Basal ganglia calcification (HP:0002135)1.56559902
171Thyroid-stimulating hormone excess (HP:0002925)1.55275633
172Inflammation of the large intestine (HP:0002037)1.54778411
173Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.53811090
174Back pain (HP:0003418)1.53807773
175Thrombocytosis (HP:0001894)1.53700940
176Renal tubular acidosis (HP:0001947)1.52987034
177Increased serum ferritin (HP:0003281)1.52985975
178Obstructive lung disease (HP:0006536)1.52792866
179Chronic obstructive pulmonary disease (HP:0006510)1.52792866
180Insidious onset (HP:0003587)1.52435805
181Termporal pattern (HP:0011008)1.52435805
182Episodic fever (HP:0001954)1.52361911
183Vertigo (HP:0002321)1.49452821
184Abnormality of magnesium homeostasis (HP:0004921)1.48151462
185Mitral stenosis (HP:0001718)1.46975630
186Tetraparesis (HP:0002273)1.45754982
187Leiomyosarcoma (HP:0100243)1.45673531
188Uterine leiomyosarcoma (HP:0002891)1.45673531
189Gastrointestinal dysmotility (HP:0002579)1.43400022
190Cardiovascular calcification (HP:0011915)1.42012772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.87605038
2ACVR1B3.25672520
3FRK3.00771352
4MST1R2.88054298
5RIPK12.86553080
6TEC2.70388199
7BTK2.65978687
8MST42.65833722
9PIK3CG2.26821782
10EPHA22.24754172
11EIF2AK12.23415421
12CSF1R2.12043938
13MAP2K22.05611743
14SYK2.04549613
15TAOK312.8161096
16GRK51.88444543
17MAP3K91.86095935
18ZAP701.81168845
19GRK61.80868718
20KSR21.78175576
21TAOK11.70825438
22STK241.66773488
23NME11.63196699
24PTK61.58926072
25EPHA31.54344507
26PIK3CA1.49955569
27LMTK21.47180645
28MAP3K131.42098113
29PRKG21.38617634
30TNIK1.35346919
31HCK1.31819235
32ARAF1.29121650
33MAP3K21.22809614
34BLK1.21136299
35PTK21.20211518
36MAPKAPK31.16483602
37LYN1.14695768
38ICK1.08592496
39IRAK11.08100472
40DAPK21.02918997
41DAPK30.99949907
42ADRBK20.99391431
43MAP2K10.98469009
44RIPK40.96639095
45TESK10.95708450
46MAP3K140.93920167
47ERN10.90375709
48FES0.89473052
49MET0.87610892
50RET0.87062506
51KDR0.86387059
52IKBKB0.85251020
53AKT30.82969559
54MAP3K50.82648828
55TXK0.80062814
56SIK30.78034003
57PRKCI0.73792092
58PDGFRB0.73556021
59EPHB10.70507424
60TNK20.66823667
61PRKD10.66816078
62MAP2K30.66257523
63MAP3K120.65156382
64STK390.64704998
65TTK0.63598580
66NLK0.61895280
67TRIM280.61448261
68ADRBK10.60962864
69ERBB20.60261962
70YES10.58792926
71JAK10.58339506
72PLK20.57746391
73PAK40.57123340
74STK100.56440299
75MAP3K80.55958372
76TLK10.53546079
77MYLK0.53445822
78FER0.52698746
79IRAK30.51800996
80TAOK20.50083622
81MOS0.49333230
82ERBB40.48780080
83FYN0.48373507
84MATK0.48343011
85LCK0.47745712
86PNCK0.47446003
87AURKB0.47314709
88MAP3K10.47184147
89DAPK10.46915374
90STK40.44389244
91MAP3K30.43896875
92MAP3K100.41977226
93KSR10.41249522
94MAPK110.41076821
95JAK30.40884286
96DMPK0.40422911
97TESK20.39771025
98PAK10.38703177
99PRKAA20.38375434
100MAP2K60.38178547
101PRKG10.37547965
102PTK2B0.36688928
103LIMK10.36438726
104CAMK2D0.36332356
105NUAK10.35266167
106MINK10.34805721
107LATS10.34715564
108DDR20.34708101
109MAP4K10.34242156
110IGF1R0.33804904
111BMX0.33717065
112BRAF0.32212347
113MARK30.31957978
114ILK0.31512671
115SRC0.31410884
116PIM10.30645291
117MELK0.30569641
118PDPK10.29719957
119PKN10.29527286
120PRKCB0.29356148
121ITK0.26981446
122TYK20.24057641
123PRKCQ0.23237662
124PAK30.23068071
125PDK10.22063939
126PRKCA0.21655952
127STK110.20981106
128CAMK2B0.20894397
129BMPR20.20669030
130RAF10.20186990
131CAMK2G0.19734780
132CSK0.16534888
133FGFR10.14133493
134LATS20.12457314
135PRKAA10.12431172
136FGR0.10562721
137MAP3K70.09299034
138AKT20.09120020
139LRRK20.08766756
140DYRK20.08532671
141FGFR40.07036210
142ABL20.05108239
143GRK10.05002282
144PIM20.04838808
145PRKD20.04313157
146CDK70.04126895
147PDK20.03702108
148CAMK2A0.03122147
149PRKACG0.02525548
150TBK10.02165011
151RPS6KA10.01839862
152JAK20.01731460
153MAPKAPK20.01581403
154EEF2K0.01556522
155PRKCD0.01346589
156STK30.00705209

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.54377171
2Fat digestion and absorption_Homo sapiens_hsa049754.33183592
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.29807335
4Mineral absorption_Homo sapiens_hsa049784.22045003
5Platelet activation_Homo sapiens_hsa046114.02361305
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.73617274
7Renin-angiotensin system_Homo sapiens_hsa046142.97581007
8Caffeine metabolism_Homo sapiens_hsa002322.70919411
9Vitamin digestion and absorption_Homo sapiens_hsa049772.56818138
10Nitrogen metabolism_Homo sapiens_hsa009102.47327973
11Bile secretion_Homo sapiens_hsa049762.37435145
12Galactose metabolism_Homo sapiens_hsa000522.29628786
13SNARE interactions in vesicular transport_Homo sapiens_hsa041302.21665173
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.13867187
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.03914296
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.89297647
17Fructose and mannose metabolism_Homo sapiens_hsa000511.88953099
18Hematopoietic cell lineage_Homo sapiens_hsa046401.82815619
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.62711146
20Thyroid hormone synthesis_Homo sapiens_hsa049181.61315456
21Starch and sucrose metabolism_Homo sapiens_hsa005001.48964333
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47818074
23Chemokine signaling pathway_Homo sapiens_hsa040621.45097949
24Protein digestion and absorption_Homo sapiens_hsa049741.42223853
25Gap junction_Homo sapiens_hsa045401.39262160
26Histidine metabolism_Homo sapiens_hsa003401.32261146
27ECM-receptor interaction_Homo sapiens_hsa045121.31529656
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22017194
29Vascular smooth muscle contraction_Homo sapiens_hsa042701.19455665
30Serotonergic synapse_Homo sapiens_hsa047261.17917253
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16387840
32PPAR signaling pathway_Homo sapiens_hsa033201.15351008
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15269942
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15248530
35Glutathione metabolism_Homo sapiens_hsa004801.14034966
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13610259
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.12624983
38Systemic lupus erythematosus_Homo sapiens_hsa053221.11420442
39Folate biosynthesis_Homo sapiens_hsa007901.09702351
40Salivary secretion_Homo sapiens_hsa049701.08921292
41Tight junction_Homo sapiens_hsa045301.07955046
42Glycerolipid metabolism_Homo sapiens_hsa005611.04362162
43Staphylococcus aureus infection_Homo sapiens_hsa051501.02936944
44Arginine biosynthesis_Homo sapiens_hsa002200.98247012
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.98218614
46Retinol metabolism_Homo sapiens_hsa008300.97888247
47Endocytosis_Homo sapiens_hsa041440.94558120
48African trypanosomiasis_Homo sapiens_hsa051430.93344603
49Collecting duct acid secretion_Homo sapiens_hsa049660.93192065
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.92217420
51Alcoholism_Homo sapiens_hsa050340.91046482
52Salmonella infection_Homo sapiens_hsa051320.90734778
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89627850
54B cell receptor signaling pathway_Homo sapiens_hsa046620.88981152
55Tryptophan metabolism_Homo sapiens_hsa003800.86959859
56Asthma_Homo sapiens_hsa053100.86120172
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83678008
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80431955
59Pentose phosphate pathway_Homo sapiens_hsa000300.78424882
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78030317
61Linoleic acid metabolism_Homo sapiens_hsa005910.77999584
62Oxidative phosphorylation_Homo sapiens_hsa001900.77688434
63Fatty acid elongation_Homo sapiens_hsa000620.76572294
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75236911
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75011689
66Hepatitis C_Homo sapiens_hsa051600.73451529
67Shigellosis_Homo sapiens_hsa051310.72831865
68TNF signaling pathway_Homo sapiens_hsa046680.71351577
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.70834293
70Autoimmune thyroid disease_Homo sapiens_hsa053200.69242761
71Graft-versus-host disease_Homo sapiens_hsa053320.69086748
72Alzheimers disease_Homo sapiens_hsa050100.65128825
73Phagosome_Homo sapiens_hsa041450.64481418
74Allograft rejection_Homo sapiens_hsa053300.64384161
75Choline metabolism in cancer_Homo sapiens_hsa052310.63262756
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62913241
77Sphingolipid metabolism_Homo sapiens_hsa006000.62844035
78Long-term depression_Homo sapiens_hsa047300.61217493
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61208186
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59875748
81Bladder cancer_Homo sapiens_hsa052190.58223412
82Pancreatic secretion_Homo sapiens_hsa049720.58214136
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.57456623
84Type II diabetes mellitus_Homo sapiens_hsa049300.57209518
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57117799
86Toxoplasmosis_Homo sapiens_hsa051450.56595747
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.55214627
88Renin secretion_Homo sapiens_hsa049240.54557957
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54317997
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53865114
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53552076
92Thyroid cancer_Homo sapiens_hsa052160.53161347
93Arginine and proline metabolism_Homo sapiens_hsa003300.52495803
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51277465
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50697486
96Complement and coagulation cascades_Homo sapiens_hsa046100.50629068
97Adherens junction_Homo sapiens_hsa045200.50584976
98Steroid biosynthesis_Homo sapiens_hsa001000.50568674
99Pertussis_Homo sapiens_hsa051330.49964063
100Amoebiasis_Homo sapiens_hsa051460.49718648
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49194735
102T cell receptor signaling pathway_Homo sapiens_hsa046600.47832053
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47666584
104Osteoclast differentiation_Homo sapiens_hsa043800.47179664
105Malaria_Homo sapiens_hsa051440.46643370
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46384134
107Focal adhesion_Homo sapiens_hsa045100.45803889
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.45779699
109Rap1 signaling pathway_Homo sapiens_hsa040150.45552701
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45424155
111Small cell lung cancer_Homo sapiens_hsa052220.44910214
112Parkinsons disease_Homo sapiens_hsa050120.44042172
113Arachidonic acid metabolism_Homo sapiens_hsa005900.43706318
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43590386
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43537478
116Butanoate metabolism_Homo sapiens_hsa006500.43283986
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41702507
118Endometrial cancer_Homo sapiens_hsa052130.41021167
119VEGF signaling pathway_Homo sapiens_hsa043700.40330580
120Fatty acid degradation_Homo sapiens_hsa000710.40215697
121Chronic myeloid leukemia_Homo sapiens_hsa052200.39843549
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.39723298
123Ether lipid metabolism_Homo sapiens_hsa005650.39156195
124Ovarian steroidogenesis_Homo sapiens_hsa049130.37737634
125Chemical carcinogenesis_Homo sapiens_hsa052040.37541277
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35930255
127Ras signaling pathway_Homo sapiens_hsa040140.34168297
128Cardiac muscle contraction_Homo sapiens_hsa042600.32936754
129Carbon metabolism_Homo sapiens_hsa012000.32553679
130Primary immunodeficiency_Homo sapiens_hsa053400.31648980
131Apoptosis_Homo sapiens_hsa042100.29328086
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28792499
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28202567
134ErbB signaling pathway_Homo sapiens_hsa040120.27862408
135HIF-1 signaling pathway_Homo sapiens_hsa040660.26103445
136Metabolic pathways_Homo sapiens_hsa011000.25779448
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.25609629
138ABC transporters_Homo sapiens_hsa020100.24620123
139Gastric acid secretion_Homo sapiens_hsa049710.24195469
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23064932
141Influenza A_Homo sapiens_hsa051640.22567913
142GnRH signaling pathway_Homo sapiens_hsa049120.19080934
143Leishmaniasis_Homo sapiens_hsa051400.18260176
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17705555
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17498031
146Intestinal immune network for IgA production_Homo sapiens_hsa046720.15275282
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14337394
148Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13871616

Most similar genes based on co-expression Upload to Enrichr

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