TRIM41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)7.83948348
2behavioral response to nicotine (GO:0035095)6.71138450
3regulation of skeletal muscle contraction (GO:0014819)4.96163432
4detection of light stimulus involved in sensory perception (GO:0050962)4.64309894
5detection of light stimulus involved in visual perception (GO:0050908)4.64309894
6DNA strand renaturation (GO:0000733)4.50528211
7negative regulation of cell aging (GO:0090344)4.47263067
8meiotic chromosome segregation (GO:0045132)4.33069150
9mitotic cell cycle arrest (GO:0071850)4.32870313
10regulation of synapse structural plasticity (GO:0051823)4.22259039
11cellular anion homeostasis (GO:0030002)4.17289420
12regulation of hippo signaling (GO:0035330)4.16058059
13purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.09208050
143-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.09208050
15positive regulation of fatty acid oxidation (GO:0046321)4.06813552
16purinergic nucleotide receptor signaling pathway (GO:0035590)4.05806690
17sulfation (GO:0051923)4.04737459
18transepithelial transport (GO:0070633)3.98461486
19peptidyl-lysine dimethylation (GO:0018027)3.87644428
20heterochromatin organization (GO:0070828)3.85824738
21negative regulation of cell size (GO:0045792)3.74536525
22cilium or flagellum-dependent cell motility (GO:0001539)3.68939831
23cellular response to exogenous dsRNA (GO:0071360)3.68388770
24positive regulation of protein kinase C signaling (GO:0090037)3.68379614
25positive regulation of CREB transcription factor activity (GO:0032793)3.67208679
26peristalsis (GO:0030432)3.64971723
27regulation of cholesterol homeostasis (GO:2000188)3.63790143
28cornea development in camera-type eye (GO:0061303)3.58524535
29DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.54356409
30response to ATP (GO:0033198)3.53912356
31lens fiber cell differentiation (GO:0070306)3.52299521
32urinary tract smooth muscle contraction (GO:0014848)3.48862169
33positive regulation of histone deacetylation (GO:0031065)3.48144069
34GDP-mannose metabolic process (GO:0019673)3.47492177
35regulation of phospholipid biosynthetic process (GO:0071071)3.44936664
36macroautophagy (GO:0016236)3.43563875
37protein import into peroxisome matrix (GO:0016558)3.38181670
38negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.37903205
39neuromuscular synaptic transmission (GO:0007274)3.36763879
40maternal placenta development (GO:0001893)3.36516306
41gamma-aminobutyric acid transport (GO:0015812)3.34713932
42regulation of cytokine production involved in inflammatory response (GO:1900015)3.34263095
43pre-miRNA processing (GO:0031054)3.30820898
44regulation of nuclear cell cycle DNA replication (GO:0033262)3.28594375
45sensory perception of taste (GO:0050909)3.25283944
46regulation of fatty acid beta-oxidation (GO:0031998)3.14925230
47synaptonemal complex assembly (GO:0007130)3.13515912
48tryptophan catabolic process (GO:0006569)3.12829960
49indole-containing compound catabolic process (GO:0042436)3.12829960
50indolalkylamine catabolic process (GO:0046218)3.12829960
51activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.12799320
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.08109404
53dicarboxylic acid biosynthetic process (GO:0043650)3.05363205
54sulfur amino acid catabolic process (GO:0000098)3.02987020
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02432896
564-hydroxyproline metabolic process (GO:0019471)3.00680929
57nucleoside transmembrane transport (GO:1901642)3.00352908
58indolalkylamine metabolic process (GO:0006586)2.98707188
59snRNA transcription (GO:0009301)2.98679476
60positive regulation of nuclease activity (GO:0032075)2.97443593
61alpha-linolenic acid metabolic process (GO:0036109)2.96335374
62positive regulation of triglyceride biosynthetic process (GO:0010867)2.95508415
63spinal cord motor neuron differentiation (GO:0021522)2.93087605
64DNA damage response, signal transduction resulting in transcription (GO:0042772)2.91641724
65negative regulation of Rho protein signal transduction (GO:0035024)2.91053101
66adherens junction assembly (GO:0034333)2.90961018
67synaptonemal complex organization (GO:0070193)2.90850225
68establishment of apical/basal cell polarity (GO:0035089)2.90257091
69protein localization to endosome (GO:0036010)2.88640096
70neuronal action potential (GO:0019228)2.87683723
71negative regulation of fatty acid biosynthetic process (GO:0045717)2.85143486
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.82931427
73apoptotic cell clearance (GO:0043277)2.82199008
74fucose catabolic process (GO:0019317)2.80755036
75L-fucose metabolic process (GO:0042354)2.80755036
76L-fucose catabolic process (GO:0042355)2.80755036
77cytoplasmic mRNA processing body assembly (GO:0033962)2.80608288
78RNA stabilization (GO:0043489)2.80304112
79mRNA stabilization (GO:0048255)2.80304112
80lysine catabolic process (GO:0006554)2.78017747
81lysine metabolic process (GO:0006553)2.78017747
82nephron epithelium morphogenesis (GO:0072088)2.77770302
83nephron tubule morphogenesis (GO:0072078)2.77770302
84flavonoid metabolic process (GO:0009812)2.77292319
85L-alpha-amino acid transmembrane transport (GO:1902475)2.76587662
86NAD biosynthetic process (GO:0009435)2.75468583
87motile cilium assembly (GO:0044458)2.74947554
88cell-substrate adherens junction assembly (GO:0007045)2.74357612
89focal adhesion assembly (GO:0048041)2.74357612
90embryonic placenta development (GO:0001892)2.74145847
91purinergic receptor signaling pathway (GO:0035587)2.72722906
92mitotic G1 DNA damage checkpoint (GO:0031571)2.72252470
93phosphatidylethanolamine biosynthetic process (GO:0006646)2.71604419
94regulation of posttranscriptional gene silencing (GO:0060147)2.71090791
95regulation of gene silencing by miRNA (GO:0060964)2.71090791
96regulation of gene silencing by RNA (GO:0060966)2.71090791
97sex determination (GO:0007530)2.70995501
98regulation of p38MAPK cascade (GO:1900744)2.70973362
99regulation of hydrogen peroxide metabolic process (GO:0010310)2.69615910
100phosphatidylglycerol biosynthetic process (GO:0006655)2.68832596
101regulation of nuclease activity (GO:0032069)2.67817675
102positive regulation of defense response to virus by host (GO:0002230)2.67311384
103regulation of action potential (GO:0098900)2.66959378
104cell-substrate junction assembly (GO:0007044)2.66928547
105positive regulation of fatty acid beta-oxidation (GO:0032000)2.66697455
106regulation of fatty acid oxidation (GO:0046320)2.66516645
107plasma membrane repair (GO:0001778)2.66415210
108insulin-like growth factor receptor signaling pathway (GO:0048009)2.65508843
109low-density lipoprotein particle clearance (GO:0034383)2.65296543
110negative regulation of reactive oxygen species metabolic process (GO:2000378)2.64110788
111tRNA modification (GO:0006400)2.62890902
112behavioral response to pain (GO:0048266)2.62580197
113response to misfolded protein (GO:0051788)2.62455405
114G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.60984652
115cell proliferation in forebrain (GO:0021846)2.60473759
116regulation of chromatin binding (GO:0035561)2.59766905
117kynurenine metabolic process (GO:0070189)2.59492495
118epithelial cell differentiation involved in prostate gland development (GO:0060742)2.59471819
119carnitine shuttle (GO:0006853)2.59199033
120positive regulation of p38MAPK cascade (GO:1900745)2.58226557
121gene silencing by RNA (GO:0031047)2.58115816
122regulation of translational fidelity (GO:0006450)2.57935093
123glucocorticoid receptor signaling pathway (GO:0042921)2.57832089
124mannose metabolic process (GO:0006013)2.57384133
125axoneme assembly (GO:0035082)2.55884369
126fatty acid transmembrane transport (GO:1902001)2.55873739
127negative regulation of lipid transport (GO:0032369)2.55773857
128indole-containing compound metabolic process (GO:0042430)2.54622620
129protein carboxylation (GO:0018214)2.54408623
130peptidyl-glutamic acid carboxylation (GO:0017187)2.54408623
131tryptophan metabolic process (GO:0006568)2.54112880
132NLS-bearing protein import into nucleus (GO:0006607)2.54102063
133intracellular estrogen receptor signaling pathway (GO:0030520)2.53983113
134DNA methylation involved in gamete generation (GO:0043046)2.53406650
135urea metabolic process (GO:0019627)2.53040935
136urea cycle (GO:0000050)2.53040935
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52536929
138endoplasmic reticulum unfolded protein response (GO:0030968)2.52183926
139adenosine receptor signaling pathway (GO:0001973)2.49912518
140COPI coating of Golgi vesicle (GO:0048205)2.49548569
141Golgi transport vesicle coating (GO:0048200)2.49548569
142histone H4-K12 acetylation (GO:0043983)2.49500964
143reciprocal DNA recombination (GO:0035825)2.49321104
144reciprocal meiotic recombination (GO:0007131)2.49321104
145regulation of mesoderm development (GO:2000380)2.48688416
146regulation of cholesterol storage (GO:0010885)2.48100645
147apoptotic process involved in morphogenesis (GO:0060561)2.47160455
148preassembly of GPI anchor in ER membrane (GO:0016254)2.46477770
149regulation of translational termination (GO:0006449)2.45330559
150serine family amino acid catabolic process (GO:0009071)2.45201390
151membrane depolarization during action potential (GO:0086010)2.45061175
152regulation of synapse maturation (GO:0090128)2.44480160
153piRNA metabolic process (GO:0034587)2.44203372
154trivalent inorganic anion homeostasis (GO:0072506)2.43865474
155phosphate ion homeostasis (GO:0055062)2.43865474
156misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.42103928
157positive regulation of heat generation (GO:0031652)2.41812171
158cellular response to unfolded protein (GO:0034620)2.41683746
159carnitine transmembrane transport (GO:1902603)2.41638516
160phosphatidylethanolamine metabolic process (GO:0046337)2.41248399
161histone H3-K9 demethylation (GO:0033169)2.40824913
162primary amino compound metabolic process (GO:1901160)2.40583295
163positive regulation of triglyceride metabolic process (GO:0090208)2.40101188
164gene silencing (GO:0016458)2.39750413
165regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38664043
166regulation of protein polyubiquitination (GO:1902914)2.38511252
167hormone catabolic process (GO:0042447)2.38382086
168mitotic G1/S transition checkpoint (GO:0044819)2.37966842
169triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.37915641
170regulation of clathrin-mediated endocytosis (GO:2000369)2.37846107
171ER-nucleus signaling pathway (GO:0006984)2.37824097
172carnitine transport (GO:0015879)2.37146356
173amino-acid betaine transport (GO:0015838)2.37146356
174positive regulation of glycogen biosynthetic process (GO:0045725)2.37139751
175stress fiber assembly (GO:0043149)2.34912644
176trophectodermal cell differentiation (GO:0001829)2.34647166
177negative regulation of nucleotide catabolic process (GO:0030812)2.34612491
178cellular modified amino acid catabolic process (GO:0042219)2.32593371
179regulation of NFAT protein import into nucleus (GO:0051532)2.32345173
180fatty acid homeostasis (GO:0055089)2.31586379
181regulation of triglyceride biosynthetic process (GO:0010866)2.31364123
182epithelial cell-cell adhesion (GO:0090136)2.31339541
183regulation of fatty acid biosynthetic process (GO:0042304)2.30250175
184polarized epithelial cell differentiation (GO:0030859)2.28732579
185negative regulation of sterol transport (GO:0032372)2.28534283
186negative regulation of cholesterol transport (GO:0032375)2.28534283
187negative regulation of fibrinolysis (GO:0051918)2.28391736
188erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.28170208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.38642970
2CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.93297636
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92593444
4* RXR_22158963_ChIP-Seq_LIVER_Mouse2.79896295
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.69070642
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44442528
7E2F1_20622854_ChIP-Seq_HELA_Human2.43500342
8* TCF7_22412390_ChIP-Seq_EML_Mouse2.38001191
9* MYC_22102868_ChIP-Seq_BL_Human2.37444162
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.35724630
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.31790941
12ZNF263_19887448_ChIP-Seq_K562_Human2.28244471
13CTCF_27219007_Chip-Seq_Bcells_Human2.23763376
14KDM2B_26808549_Chip-Seq_DND41_Human2.23612195
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18393046
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17628313
17LXR_22292898_ChIP-Seq_THP-1_Human2.15711210
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15476280
19BCOR_27268052_Chip-Seq_Bcells_Human2.14337645
20DROSHA_22980978_ChIP-Seq_HELA_Human2.14196345
21BCL6_27268052_Chip-Seq_Bcells_Human2.13412589
22* PHF8_20622854_ChIP-Seq_HELA_Human2.12759903
23EZH2_22144423_ChIP-Seq_EOC_Human2.04108449
24* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03373392
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00435762
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00393754
27SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.99657987
28MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.99386652
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98060828
30SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.97737734
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96735137
32ERA_21632823_ChIP-Seq_H3396_Human1.96113980
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.95662488
34MAF_26560356_Chip-Seq_TH2_Human1.90491120
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.88086754
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87754348
37* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86841015
38* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.85929476
39KDM2B_26808549_Chip-Seq_K562_Human1.85769973
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.85507813
41RACK7_27058665_Chip-Seq_MCF-7_Human1.82578040
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81362612
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80751254
44CTCF_20526341_ChIP-Seq_ESCs_Human1.75711879
45CLOCK_20551151_ChIP-Seq_293T_Human1.73813093
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.73671348
47* VDR_21846776_ChIP-Seq_THP-1_Human1.72479453
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69922268
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.69321176
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.69242768
51YY1_22570637_ChIP-Seq_MALME-3M_Human1.67507953
52RARB_24833708_ChIP-Seq_LIVER_Mouse1.65813570
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65739863
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.61994591
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61119112
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60393569
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60090299
58* KDM2B_26808549_Chip-Seq_JURKAT_Human1.57670760
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.57573644
60ATF3_27146783_Chip-Seq_COLON_Human1.57091543
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.56096716
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56092102
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.55364043
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.53908339
65CREB1_26743006_Chip-Seq_LNCaP_Human1.52475540
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.49108675
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48660388
68RARA_24833708_ChIP-Seq_LIVER_Mouse1.47388065
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47169988
70OCT4_19829295_ChIP-Seq_ESCs_Human1.45441888
71SA1_27219007_Chip-Seq_Bcells_Human1.45278533
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45146802
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44980547
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43780938
75* FOXP1_21924763_ChIP-Seq_HESCs_Human1.43762018
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43314815
77NCOR1_26117541_ChIP-Seq_K562_Human1.42938169
78* VDR_24763502_ChIP-Seq_THP-1_Human1.41841588
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41489872
80CTCF_21964334_Chip-Seq_Bcells_Human1.40014253
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.39964485
82RXRA_24833708_ChIP-Seq_LIVER_Mouse1.39045771
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.38994450
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.38933672
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38769910
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38769910
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38769910
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37475714
89P300_27268052_Chip-Seq_Bcells_Human1.36742165
90OCT4_20526341_ChIP-Seq_ESCs_Human1.34924888
91TAF2_19829295_ChIP-Seq_ESCs_Human1.34494301
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32727322
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32706246
94* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32189025
95P53_21459846_ChIP-Seq_SAOS-2_Human1.31641666
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31059551
97RAC3_21632823_ChIP-Seq_H3396_Human1.30601015
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30187860
99JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29548928
100P68_20966046_ChIP-Seq_HELA_Human1.28315701
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27919540
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27221548
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26058050
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25906946
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25048632
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24958095
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24945272
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24165091
109NANOG_20526341_ChIP-Seq_ESCs_Human1.23991089
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.23328047
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22238403
112TP53_22127205_ChIP-Seq_IMR90_Human1.18689466
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18553037
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18417511
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.18274566
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.18141425
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.18104794
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17909981
119FOXA2_19822575_ChIP-Seq_HepG2_Human1.17559295
120RNF2_27304074_Chip-Seq_ESCs_Mouse1.17153561
121ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17054550
122* XRN2_22483619_ChIP-Seq_HELA_Human1.17015341
123HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15340978
124GATA6_25053715_ChIP-Seq_YYC3_Human1.14954640
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14803113
126NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14755451
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14632928
128* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13948573
129RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13831270
130* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13219789
131SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13166062
132REST_21632747_ChIP-Seq_MESCs_Mouse1.12715619
133TBX20_22328084_ChIP-Seq_HEART_Mouse1.12240360
134TBX20_22080862_ChIP-Seq_HEART_Mouse1.12240360
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11804110
136CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11579193
137* UTX_26944678_Chip-Seq_JUKART_Human1.09715954
138STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.07513053
139* MAF_26560356_Chip-Seq_TH1_Human1.07388559
140* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07372896
141FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06673016
142P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.06660536
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06625208
144CTCF_26484167_Chip-Seq_Bcells_Mouse1.06467321
145SMC4_20622854_ChIP-Seq_HELA_Human1.06397535
146TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06258071
147ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06098825
148* TP53_23651856_ChIP-Seq_MEFs_Mouse1.05480155
149POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05170420
150UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04311236
151TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03707381
152GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03250315
153MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02859619
154TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02562855
155EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02344848
156ERG_21242973_ChIP-ChIP_JURKAT_Human1.01948780
157NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.01698029
158IRF8_22096565_ChIP-ChIP_GC-B_Human1.01661669
159* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01223873
160EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00146156
161MYC_19829295_ChIP-Seq_ESCs_Human1.00072548
162ESR1_21235772_ChIP-Seq_MCF-7_Human0.99945622
163POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99908357
164PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99794570
165GATA1_19941826_ChIP-Seq_K562_Human0.99648918
166SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98634662
167CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98574444
168TP63_22573176_ChIP-Seq_HFKS_Human0.98426710
169* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96265730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.13101157
2MP0001986_abnormal_taste_sensitivity4.81580004
3MP0005171_absent_coat_pigmentation4.37659142
4MP0005423_abnormal_somatic_nervous4.27737204
5MP0005174_abnormal_tail_pigmentation4.14245575
6MP0003136_yellow_coat_color4.04053070
7MP0005360_urolithiasis3.24672961
8MP0002139_abnormal_hepatobiliary_system3.13962837
9MP0001968_abnormal_touch/_nociception3.08843197
10MP0005365_abnormal_bile_salt2.64330742
11MP0008961_abnormal_basal_metabolism2.64177631
12MP0002160_abnormal_reproductive_system2.63567608
13MP0010234_abnormal_vibrissa_follicle2.53174509
14MP0005076_abnormal_cell_differentiation2.47183405
15MP0002877_abnormal_melanocyte_morpholog2.18748312
16MP0005085_abnormal_gallbladder_physiolo2.16473345
17MP0001502_abnormal_circadian_rhythm2.14837682
18MP0004043_abnormal_pH_regulation2.08611489
19MP0003252_abnormal_bile_duct2.05079866
20MP0004185_abnormal_adipocyte_glucose2.03749370
21MP0005551_abnormal_eye_electrophysiolog2.02823549
22MP0004264_abnormal_extraembryonic_tissu2.01865294
23MP0010352_gastrointestinal_tract_polyps2.01367825
24MP0003300_gastrointestinal_ulcer1.96709609
25MP0003191_abnormal_cellular_cholesterol1.95359285
26MP0003566_abnormal_cell_adhesion1.90518633
27MP0004381_abnormal_hair_follicle1.90231488
28MP0002736_abnormal_nociception_after1.88783020
29MP0009840_abnormal_foam_cell1.87213973
30MP0001849_ear_inflammation1.85742658
31MP0009780_abnormal_chondrocyte_physiolo1.84437083
32MP0003283_abnormal_digestive_organ1.83869176
33MP0002638_abnormal_pupillary_reflex1.72913477
34MP0005666_abnormal_adipose_tissue1.69384223
35MP0005409_darkened_coat_color1.68697855
36MP0001873_stomach_inflammation1.67825260
37MP0002735_abnormal_chemical_nociception1.66150617
38MP0009278_abnormal_bone_marrow1.64594519
39MP0005623_abnormal_meninges_morphology1.62528256
40MP0002653_abnormal_ependyma_morphology1.62435253
41MP0003045_fibrosis1.61352003
42MP0005083_abnormal_biliary_tract1.60822374
43MP0002876_abnormal_thyroid_physiology1.59045062
44MP0001188_hyperpigmentation1.58237237
45MP0001661_extended_life_span1.57769866
46MP0005389_reproductive_system_phenotype1.55271000
47MP0002249_abnormal_larynx_morphology1.55035188
48MP0005670_abnormal_white_adipose1.53755745
49MP0003879_abnormal_hair_cell1.53455334
50MP0004145_abnormal_muscle_electrophysio1.52983154
51MP0010329_abnormal_lipoprotein_level1.52687108
52MP0000750_abnormal_muscle_regeneration1.47267064
53MP0004885_abnormal_endolymph1.46547742
54MP0008872_abnormal_physiological_respon1.42796909
55MP0005375_adipose_tissue_phenotype1.42767125
56MP0009053_abnormal_anal_canal1.42129747
57MP0009745_abnormal_behavioral_response1.40651997
58MP0001919_abnormal_reproductive_system1.38281755
59MP0002254_reproductive_system_inflammat1.37267632
60MP0001765_abnormal_ion_homeostasis1.36579636
61MP0004130_abnormal_muscle_cell1.36405351
62MP0010630_abnormal_cardiac_muscle1.36328060
63MP0001970_abnormal_pain_threshold1.34553212
64MP0010307_abnormal_tumor_latency1.33479809
65MP0001756_abnormal_urination1.32472983
66MP0000538_abnormal_urinary_bladder1.30330601
67MP0002064_seizures1.29095508
68MP0004197_abnormal_fetal_growth/weight/1.27289159
69MP0000678_abnormal_parathyroid_gland1.27027488
70MP0003195_calcinosis1.26360033
71MP0003119_abnormal_digestive_system1.26307422
72MP0001485_abnormal_pinna_reflex1.26032310
73MP0000609_abnormal_liver_physiology1.25861391
74MP0004087_abnormal_muscle_fiber1.25784330
75MP0002269_muscular_atrophy1.25534553
76MP0005646_abnormal_pituitary_gland1.25145690
77MP0008875_abnormal_xenobiotic_pharmacok1.21893905
78MP0002086_abnormal_extraembryonic_tissu1.21348197
79MP0000003_abnormal_adipose_tissue1.21167604
80MP0003635_abnormal_synaptic_transmissio1.20579922
81MP0005377_hearing/vestibular/ear_phenot1.18217577
82MP0003878_abnormal_ear_physiology1.18217577
83MP0000569_abnormal_digit_pigmentation1.18180057
84MP0002138_abnormal_hepatobiliary_system1.17087315
85MP0001664_abnormal_digestion1.17019807
86MP0002084_abnormal_developmental_patter1.16571683
87MP0000015_abnormal_ear_pigmentation1.16349104
88MP0000470_abnormal_stomach_morphology1.15831426
89MP0004233_abnormal_muscle_weight1.15770992
90MP0002063_abnormal_learning/memory/cond1.14533418
91MP0002272_abnormal_nervous_system1.14378527
92MP0009672_abnormal_birth_weight1.13517914
93MP0005410_abnormal_fertilization1.10214543
94MP0001348_abnormal_lacrimal_gland1.09370113
95MP0003303_peritoneal_inflammation1.06542865
96MP0000631_abnormal_neuroendocrine_gland1.05873606
97MP0005332_abnormal_amino_acid1.05772166
98MP0003115_abnormal_respiratory_system1.05037812
99MP0003984_embryonic_growth_retardation1.04708365
100MP0002088_abnormal_embryonic_growth/wei1.04368211
101MP0000733_abnormal_muscle_development1.04188525
102MP0003453_abnormal_keratinocyte_physiol1.03490717
103MP0002909_abnormal_adrenal_gland1.03434319
104MP0005167_abnormal_blood-brain_barrier1.03333898
105MP0001672_abnormal_embryogenesis/_devel1.03173044
106MP0005380_embryogenesis_phenotype1.03173044
107MP0004084_abnormal_cardiac_muscle1.03083088
108MP0001730_embryonic_growth_arrest1.02711768
109MP0004272_abnormal_basement_membrane1.00816522
110MP0004858_abnormal_nervous_system0.99868537
111MP0005023_abnormal_wound_healing0.99221958
112MP0002118_abnormal_lipid_homeostasis0.99154596
113MP0002796_impaired_skin_barrier0.98400054
114MP0004142_abnormal_muscle_tone0.97174468
115MP0000751_myopathy0.97160289
116MP0001915_intracranial_hemorrhage0.96764896
117MP0002572_abnormal_emotion/affect_behav0.95904734
118MP0009046_muscle_twitch0.95401185
119MP0001666_abnormal_nutrient_absorption0.94185574
120MP0004133_heterotaxia0.92729088
121MP0002733_abnormal_thermal_nociception0.92591122
122MP0003646_muscle_fatigue0.92432554
123MP0000537_abnormal_urethra_morphology0.91047374
124MP0003091_abnormal_cell_migration0.90901743
125MP0002925_abnormal_cardiovascular_devel0.90405673
126MP0009384_cardiac_valve_regurgitation0.90247298
127MP0003137_abnormal_impulse_conducting0.89483463
128MP0009703_decreased_birth_body0.88516645
129MP0005448_abnormal_energy_balance0.88472248
130MP0002971_abnormal_brown_adipose0.87563243
131MP0002085_abnormal_embryonic_tissue0.87254925
132MP0000013_abnormal_adipose_tissue0.86859089
133MP0001486_abnormal_startle_reflex0.85890433
134MP0002734_abnormal_mechanical_nocicepti0.85771884
135MP0002837_dystrophic_cardiac_calcinosis0.85506929
136MP0005248_abnormal_Harderian_gland0.84838769
137MP0000026_abnormal_inner_ear0.84165147
138MP0001697_abnormal_embryo_size0.83681220
139MP0000266_abnormal_heart_morphology0.83028594
140MP0005319_abnormal_enzyme/_coenzyme0.82743262
141MP0005187_abnormal_penis_morphology0.82345770
142MP0006292_abnormal_olfactory_placode0.82027730
143MP0005058_abnormal_lysosome_morphology0.81982608
144MP0008770_decreased_survivor_rate0.81589939
145MP0005330_cardiomyopathy0.79940663
146MP0002697_abnormal_eye_size0.79080076
147MP0010368_abnormal_lymphatic_system0.78937118
148MP0002970_abnormal_white_adipose0.78539477
149MP0000685_abnormal_immune_system0.76934972
150MP0005253_abnormal_eye_physiology0.76482889
151MP0002928_abnormal_bile_duct0.74829242
152MP0002089_abnormal_postnatal_growth/wei0.74453358
153MP0002168_other_aberrant_phenotype0.74267429
154MP0002080_prenatal_lethality0.73957880
155MP0002234_abnormal_pharynx_morphology0.73689476
156MP0000598_abnormal_liver_morphology0.73406868
157MP0002933_joint_inflammation0.72999636
158MP0000049_abnormal_middle_ear0.71386333
159MP0006138_congestive_heart_failure0.71134639
160MP0001929_abnormal_gametogenesis0.70861438
161MP0008877_abnormal_DNA_methylation0.70854298
162MP0010030_abnormal_orbit_morphology0.70027968
163MP0000747_muscle_weakness0.69797378
164MP0001963_abnormal_hearing_physiology0.69459591
165MP0002078_abnormal_glucose_homeostasis0.68384493
166MP0009115_abnormal_fat_cell0.67856497
167MP0003868_abnormal_feces_composition0.67441105
168MP0004019_abnormal_vitamin_homeostasis0.67436735
169MP0002092_abnormal_eye_morphology0.67230363
170MP0002557_abnormal_social/conspecific_i0.65219427
171MP0002067_abnormal_sensory_capabilities0.63362461
172MP0009643_abnormal_urine_homeostasis0.63004979
173MP0004742_abnormal_vestibular_system0.62803324
174MP0003632_abnormal_nervous_system0.61783362
175MP0003698_abnormal_male_reproductive0.59217023
176MP0005195_abnormal_posterior_eye0.58115475
177MP0002210_abnormal_sex_determination0.57564038
178MP0004859_abnormal_synaptic_plasticity0.57560621
179MP0000427_abnormal_hair_cycle0.57160629
180MP0000230_abnormal_systemic_arterial0.56676245
181MP0001905_abnormal_dopamine_level0.56476029
182MP0008995_early_reproductive_senescence0.55798507

Predicted human phenotypes

RankGene SetZ-score
1Attenuation of retinal blood vessels (HP:0007843)5.14837239
2Congenital stationary night blindness (HP:0007642)4.91789974
3Rib fusion (HP:0000902)4.77470662
4Abnormality of the lower motor neuron (HP:0002366)4.41640779
5Testicular atrophy (HP:0000029)4.29312330
6Genetic anticipation (HP:0003743)4.23599213
7Annular pancreas (HP:0001734)3.95919309
8Mesangial abnormality (HP:0001966)3.88904485
9Cerebral aneurysm (HP:0004944)3.74069901
10Aplasia/Hypoplasia of the patella (HP:0006498)3.70864462
11Patellar aplasia (HP:0006443)3.68085902
12Decreased central vision (HP:0007663)3.65549864
13Pendular nystagmus (HP:0012043)3.47474762
14Bony spicule pigmentary retinopathy (HP:0007737)3.38043021
15Deep venous thrombosis (HP:0002625)3.34367228
16Chorioretinal atrophy (HP:0000533)3.33569973
17Decreased electroretinogram (ERG) amplitude (HP:0000654)3.17447266
18Absent thumb (HP:0009777)3.14840668
19Poikiloderma (HP:0001029)3.12474363
20Hyperacusis (HP:0010780)3.10519086
21Intestinal fistula (HP:0100819)3.01132847
22Decreased circulating renin level (HP:0003351)2.96038880
23Hypoalbuminemia (HP:0003073)2.94890427
24Abnormal albumin level (HP:0012116)2.94890427
25Akinesia (HP:0002304)2.89928364
26Rectovaginal fistula (HP:0000143)2.88069385
27Rectal fistula (HP:0100590)2.88069385
28Birth length less than 3rd percentile (HP:0003561)2.85197108
29Upper limb amyotrophy (HP:0009129)2.85016277
30Distal upper limb amyotrophy (HP:0007149)2.85016277
31Hand muscle atrophy (HP:0009130)2.84619340
32Polydipsia (HP:0001959)2.83416693
33Abnormal drinking behavior (HP:0030082)2.83416693
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.82476580
35Pancreatic cysts (HP:0001737)2.82440838
36Squamous cell carcinoma (HP:0002860)2.75488044
37Dyschromatopsia (HP:0007641)2.74052728
38Hyporeflexia of lower limbs (HP:0002600)2.73278683
39Progressive cerebellar ataxia (HP:0002073)2.69956531
40Tubular atrophy (HP:0000092)2.60163202
41Short chin (HP:0000331)2.60085561
42Renovascular hypertension (HP:0100817)2.60043024
43Coronal craniosynostosis (HP:0004440)2.57150999
44Molar tooth sign on MRI (HP:0002419)2.56009453
45Abnormality of midbrain morphology (HP:0002418)2.56009453
46Turricephaly (HP:0000262)2.54374401
47Aplasia of the musculature (HP:0100854)2.53774135
48Vaginal fistula (HP:0004320)2.52182814
49Pseudobulbar signs (HP:0002200)2.50818421
50Aneurysm (HP:0002617)2.50407067
51Heterotopia (HP:0002282)2.50091095
52Male infertility (HP:0003251)2.49883619
53Ependymoma (HP:0002888)2.49691479
54Global brain atrophy (HP:0002283)2.48817965
55Elfin facies (HP:0004428)2.48463728
56Facial diplegia (HP:0001349)2.47893201
57Increased connective tissue (HP:0009025)2.47693861
58Facial hemangioma (HP:0000329)2.47642937
59Impaired smooth pursuit (HP:0007772)2.47038850
60Abnormality of the renal collecting system (HP:0004742)2.45641881
61Abnormality of DNA repair (HP:0003254)2.40867247
62Pancreatic fibrosis (HP:0100732)2.39665546
63Myotonia (HP:0002486)2.39076367
64Delayed epiphyseal ossification (HP:0002663)2.38250662
65Congenital sensorineural hearing impairment (HP:0008527)2.36971410
66Hypoplasia of the pons (HP:0012110)2.36929901
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36825549
68Lymphangioma (HP:0100764)2.34491137
69Asymmetric septal hypertrophy (HP:0001670)2.33808411
70Nephronophthisis (HP:0000090)2.33638818
71EMG: neuropathic changes (HP:0003445)2.32976081
72Myocardial infarction (HP:0001658)2.32796965
73Ulnar bowing (HP:0003031)2.32128361
74Back pain (HP:0003418)2.30758190
75Clumsiness (HP:0002312)2.30748825
76Abnormality of the nasal septum (HP:0000419)2.26595990
77Difficulty climbing stairs (HP:0003551)2.25544991
78Fetal akinesia sequence (HP:0001989)2.25467496
79Enlarged epiphyses (HP:0010580)2.25014731
80Chronic hepatic failure (HP:0100626)2.24555302
81Renal duplication (HP:0000075)2.23648749
82Duplicated collecting system (HP:0000081)2.23528530
83Insomnia (HP:0100785)2.23472501
84Shallow orbits (HP:0000586)2.23305983
85Abnormality of the Achilles tendon (HP:0005109)2.23152568
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23122438
87Cystic liver disease (HP:0006706)2.23067638
88Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21820917
89Xanthomatosis (HP:0000991)2.20529154
90Abnormality of the pons (HP:0007361)2.20010838
91Abnormality of the astrocytes (HP:0100707)2.19807403
92Astrocytoma (HP:0009592)2.19807403
93True hermaphroditism (HP:0010459)2.19268500
94Short thumb (HP:0009778)2.16410806
95Right ventricular cardiomyopathy (HP:0011663)2.16334357
96Polycythemia (HP:0001901)2.15908253
97Confusion (HP:0001289)2.13154333
98Difficulty running (HP:0009046)2.12890901
99Morphological abnormality of the middle ear (HP:0008609)2.12336695
100Mitral valve prolapse (HP:0001634)2.11421912
101Popliteal pterygium (HP:0009756)2.10578962
102Achilles tendon contracture (HP:0001771)2.09642935
103Aplasia/Hypoplasia involving the musculature (HP:0001460)2.08939777
104Macroorchidism (HP:0000053)2.08571067
105Neoplasm of the heart (HP:0100544)2.08538653
106Spastic diplegia (HP:0001264)2.07974812
107Choroideremia (HP:0001139)2.05825880
108Polyuria (HP:0000103)2.05693692
109Abnormality of the costochondral junction (HP:0000919)2.05394307
110Absent/shortened dynein arms (HP:0200106)2.03012126
111Dynein arm defect of respiratory motile cilia (HP:0012255)2.03012126
112Protruding tongue (HP:0010808)2.02589723
113Bundle branch block (HP:0011710)2.02306914
114Long toe (HP:0010511)2.02141135
115Small hand (HP:0200055)2.01373076
116Hemorrhage of the eye (HP:0011885)2.01156021
117Type II lissencephaly (HP:0007260)2.00857617
118Enlarged penis (HP:0000040)1.99804135
119Gaze-evoked nystagmus (HP:0000640)1.96611418
120Increased number of teeth (HP:0011069)1.95885295
121Cerebellar dysplasia (HP:0007033)1.93748671
122Skin nodule (HP:0200036)1.93508663
123Hemiplegia (HP:0002301)1.91904542
124Complement deficiency (HP:0004431)1.91748474
125Resting tremor (HP:0002322)1.91153834
126Bronchomalacia (HP:0002780)1.90861974
127Abnormal rod and cone electroretinograms (HP:0008323)1.90617868
128Prolonged partial thromboplastin time (HP:0003645)1.90380043
129Abnormality of the renal medulla (HP:0100957)1.89519912
130Severe muscular hypotonia (HP:0006829)1.88811250
131Intrahepatic cholestasis (HP:0001406)1.88487242
132Breast hypoplasia (HP:0003187)1.88019116
133Epidermoid cyst (HP:0200040)1.87951474
134Macular degeneration (HP:0000608)1.87917810
135Tachypnea (HP:0002789)1.87518279
136Hypoplasia of the radius (HP:0002984)1.87310251
137Colitis (HP:0002583)1.85724595
138Absent radius (HP:0003974)1.85290073
139Rectal prolapse (HP:0002035)1.84542633
140Abolished electroretinogram (ERG) (HP:0000550)1.83765278
141Genu recurvatum (HP:0002816)1.83095052
142Urethral obstruction (HP:0000796)1.82428620
143Mildly elevated creatine phosphokinase (HP:0008180)1.82420053
144Lip pit (HP:0100267)1.82305905
145Abnormal number of erythroid precursors (HP:0012131)1.82187326
146Abnormality of binocular vision (HP:0011514)1.81904010
147Diplopia (HP:0000651)1.81904010
148Bowed forearm bones (HP:0003956)1.80165877
149Bowing of the arm (HP:0006488)1.80165877
150Concave nail (HP:0001598)1.79159849
151Upper motor neuron abnormality (HP:0002127)1.78554176
152Overriding aorta (HP:0002623)1.78502911
153Protrusio acetabuli (HP:0003179)1.77786681
154Hypoalphalipoproteinemia (HP:0003233)1.75906782
155Hyperinsulinemic hypoglycemia (HP:0000825)1.73117063
156Exercise-induced myalgia (HP:0003738)1.72926019
157Ketosis (HP:0001946)1.72689729
158Bowel diverticulosis (HP:0005222)1.71912479
159Bladder diverticulum (HP:0000015)1.71873379
160Abnormality of the diencephalon (HP:0010662)1.71535052
161Reticulocytosis (HP:0001923)1.69075826
162Metaphyseal cupping (HP:0003021)1.68580138
163Ketoacidosis (HP:0001993)1.68068542
164Fibroma (HP:0010614)1.67439128
165Abnormality of complement system (HP:0005339)1.66903735
166Hypercholesterolemia (HP:0003124)1.66900418
167Hamartoma of the eye (HP:0010568)1.65356528
168Milia (HP:0001056)1.65178832
169Increased CSF protein (HP:0002922)1.65011814
170Missing ribs (HP:0000921)1.63543457
171Dysmetric saccades (HP:0000641)1.63384125
172Neoplasm of the oral cavity (HP:0100649)1.62267828
173Abnormality of the intrinsic pathway (HP:0010989)1.61983695
174Esophageal varix (HP:0002040)1.61931324
175Abnormality of endocrine pancreas physiology (HP:0012093)1.61879864
176Abnormality of the pancreatic islet cells (HP:0006476)1.61879864
177Abnormality of the ischium (HP:0003174)1.61346700
178Hypoplastic ischia (HP:0003175)1.61280236
179Hypoglycemic coma (HP:0001325)1.61067684
180Fibrous tissue neoplasm (HP:0012316)1.60471875
181Atrioventricular block (HP:0001678)1.59862936
182Hyperglycemia (HP:0003074)1.59662062
183Myoglobinuria (HP:0002913)1.58357304
184Abnormality of the nasal mucosa (HP:0000433)1.58243626
185Thin bony cortex (HP:0002753)1.58117922
186Radial bowing (HP:0002986)1.57806670
187Hallux valgus (HP:0001822)1.57284763
188Deviation of the hallux (HP:0010051)1.57236665
189Late onset (HP:0003584)1.56144841
190Abnormality of the musculature of the hand (HP:0001421)1.55777202
191Malnutrition (HP:0004395)1.55712385
192Stroke (HP:0001297)1.55112930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.64320331
2WNK44.18016522
3TLK14.06674708
4CDK123.86228945
5PKN23.67470850
6FRK3.64056319
7ADRBK22.85350898
8ERN12.73395946
9ICK2.61568670
10PRKD32.48623659
11MAP3K102.48246063
12LATS12.44743279
13RIPK12.39978751
14EEF2K2.32426468
15ACVR1B2.18138739
16ZAK2.13545683
17GRK12.12607666
18MUSK1.94897361
19PDGFRA1.88054959
20PTK61.82351002
21TYRO31.76195164
22TTN1.75761556
23PINK11.73534472
24SIK11.69058473
25BLK1.66855113
26BMPR1B1.61021630
27PDK41.60351466
28PDK31.60351466
29MAP4K11.55052574
30LATS21.50984888
31ADRBK11.45469502
32TAOK11.44538334
33STK381.43135556
34CAMK1G1.38818688
35NEK21.38397078
36MAP2K61.38350229
37MTOR1.35722034
38ALK1.32832721
39BMX1.32490475
40CAMK1D1.30376386
41DDR21.23849798
42EPHA21.21827729
43CDC42BPA1.19042556
44TAOK31.19007303
45MAP3K91.17506455
46RPS6KA61.17147543
47KSR21.08381938
48MAP2K21.06932449
49PTK21.03154569
50EPHB11.02906016
51RET1.01749953
52FGFR41.00762211
53CDK60.98687169
54PAK40.95227255
55SIK20.94581440
56MAPK120.90605058
57DYRK1B0.88975876
58STK30.86762594
59LMTK20.86131261
60MAP3K20.85632785
61LRRK20.85082854
62BRD40.85076004
63FLT30.79993693
64IKBKB0.79057217
65INSRR0.78746915
66MAPK130.78517923
67TXK0.78424087
68ZAP700.77845873
69CDK40.77749554
70DMPK0.77514850
71MAP3K60.76496661
72PAK20.73804169
73CAMKK10.73802663
74MAP3K70.72958189
75SCYL20.68462253
76STK390.66011264
77PDGFRB0.65006855
78PAK60.63726105
79PDK20.63537143
80PRKD20.62928975
81TNK20.61180785
82HIPK20.60826914
83MAP2K10.59577290
84TGFBR20.59510706
85MARK20.58207257
86STK160.58199382
87NEK10.57659503
88NTRK30.57352603
89MAP3K10.57185272
90DAPK20.56785891
91MELK0.56468634
92RPS6KA20.56319275
93RPS6KA50.56157414
94PRKAA10.55860421
95PTK2B0.55771093
96PHKG20.55400387
97PHKG10.55400387
98TGFBR10.55319609
99SYK0.55233857
100ERBB20.54358065
101CDK90.53546351
102OXSR10.53151327
103DYRK30.52941699
104JAK20.51879660
105STK110.51409858
106MET0.51028095
107CAMKK20.50269393
108SMG10.49777783
109ITK0.49591819
110MAPKAPK30.49400149
111CAMK10.48991749
112MAPK110.48689881
113GRK60.48489925
114PRKCH0.48451501
115EPHB20.48105753
116MAPK80.47902501
117TTK0.47643313
118FGFR30.47488354
119WNK10.47394772
120PRKD10.47188839
121SGK2230.46672962
122SGK4940.46672962
123PRKCQ0.46020264
124MAP3K80.45971265
125STK100.45538407
126MAP2K30.45499998
127RPS6KA10.45349997
128CHUK0.45209765
129MAPKAPK50.45201248
130PDK10.44768030
131PRKCI0.44658682
132PRKCG0.44580733
133PKN10.44376600
134CHEK20.44305003
135PDPK10.43803707
136GSK3A0.43394096
137TESK10.42967385
138MARK30.42623991
139CSK0.42424288
140MAP2K40.42264392
141BCKDK0.42183036
142MAP3K110.41854975
143PRKAA20.40123637
144KIT0.39813721
145NTRK10.39804322
146ATR0.39310569
147RPS6KC10.38648351
148RPS6KL10.38648351
149SGK30.38323100
150SGK10.37619947
151CAMK40.36933867
152PIK3CA0.36759887
153PRKCZ0.36663179
154CHEK10.36658445
155AURKA0.36122861
156NTRK20.35653730
157AKT20.35173521
158CSNK1D0.35048249
159MAPK150.34404614
160RPS6KB20.34345883
161FGFR10.34253373
162TRPM70.32761458

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.82693661
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.74580321
3Sulfur relay system_Homo sapiens_hsa041223.54202211
4Nitrogen metabolism_Homo sapiens_hsa009103.26604521
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.73686323
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.63548969
7Lysine degradation_Homo sapiens_hsa003102.35532727
8Arginine biosynthesis_Homo sapiens_hsa002202.31588480
9Nicotine addiction_Homo sapiens_hsa050332.28321663
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.13974202
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01976105
12Phototransduction_Homo sapiens_hsa047442.01678985
13Taste transduction_Homo sapiens_hsa047421.92829598
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.88143724
15Linoleic acid metabolism_Homo sapiens_hsa005911.85042994
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83570715
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80266311
18mTOR signaling pathway_Homo sapiens_hsa041501.73772029
19Dorso-ventral axis formation_Homo sapiens_hsa043201.67261140
20Fatty acid degradation_Homo sapiens_hsa000711.55405833
21Bile secretion_Homo sapiens_hsa049761.54406609
22Morphine addiction_Homo sapiens_hsa050321.52307333
23PPAR signaling pathway_Homo sapiens_hsa033201.49335256
24Insulin resistance_Homo sapiens_hsa049311.49005665
25Tryptophan metabolism_Homo sapiens_hsa003801.48691069
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44987130
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.43971397
28Selenocompound metabolism_Homo sapiens_hsa004501.42493005
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38498363
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36753925
31Fatty acid biosynthesis_Homo sapiens_hsa000611.36089533
32Calcium signaling pathway_Homo sapiens_hsa040201.32763756
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.30740230
34Glucagon signaling pathway_Homo sapiens_hsa049221.28714912
35Complement and coagulation cascades_Homo sapiens_hsa046101.28555946
36Ovarian steroidogenesis_Homo sapiens_hsa049131.28260775
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22721406
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.22352106
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.21074777
40Chronic myeloid leukemia_Homo sapiens_hsa052201.19114554
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.15730274
42Histidine metabolism_Homo sapiens_hsa003401.15542755
43Vitamin digestion and absorption_Homo sapiens_hsa049771.14305927
44Bladder cancer_Homo sapiens_hsa052191.12393586
45Glutamatergic synapse_Homo sapiens_hsa047241.11889826
46Type II diabetes mellitus_Homo sapiens_hsa049301.11147880
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10674893
48AMPK signaling pathway_Homo sapiens_hsa041521.10637628
49Fatty acid metabolism_Homo sapiens_hsa012121.08883073
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.08741306
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08070712
52Biosynthesis of amino acids_Homo sapiens_hsa012301.06694282
53Adherens junction_Homo sapiens_hsa045201.05800516
54Insulin signaling pathway_Homo sapiens_hsa049101.04793444
55Chemical carcinogenesis_Homo sapiens_hsa052041.04432497
56Circadian entrainment_Homo sapiens_hsa047131.04079066
57Fanconi anemia pathway_Homo sapiens_hsa034601.04016463
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03985328
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02881599
60Notch signaling pathway_Homo sapiens_hsa043301.01766826
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00064605
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98715312
63Non-small cell lung cancer_Homo sapiens_hsa052230.96983314
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96982108
65Primary immunodeficiency_Homo sapiens_hsa053400.96395527
66ABC transporters_Homo sapiens_hsa020100.96337739
67Cholinergic synapse_Homo sapiens_hsa047250.95617522
68Fat digestion and absorption_Homo sapiens_hsa049750.95178572
69Homologous recombination_Homo sapiens_hsa034400.93266877
70Proteoglycans in cancer_Homo sapiens_hsa052050.93131746
71VEGF signaling pathway_Homo sapiens_hsa043700.91907116
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90093195
73Glioma_Homo sapiens_hsa052140.90034994
74Estrogen signaling pathway_Homo sapiens_hsa049150.89593434
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88542408
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87267407
77Focal adhesion_Homo sapiens_hsa045100.87204848
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86468108
79Starch and sucrose metabolism_Homo sapiens_hsa005000.84881489
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.84736169
81Propanoate metabolism_Homo sapiens_hsa006400.84176445
82Cocaine addiction_Homo sapiens_hsa050300.83128419
83Carbon metabolism_Homo sapiens_hsa012000.82857087
84Ether lipid metabolism_Homo sapiens_hsa005650.80434669
85Endometrial cancer_Homo sapiens_hsa052130.80403239
86Olfactory transduction_Homo sapiens_hsa047400.80241109
87Sphingolipid metabolism_Homo sapiens_hsa006000.80232213
88Small cell lung cancer_Homo sapiens_hsa052220.79861377
89Hippo signaling pathway_Homo sapiens_hsa043900.79380314
90Pyruvate metabolism_Homo sapiens_hsa006200.77770307
91Glycerolipid metabolism_Homo sapiens_hsa005610.77331801
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.77086945
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76929297
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75853958
95Acute myeloid leukemia_Homo sapiens_hsa052210.74618131
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74534821
97Amoebiasis_Homo sapiens_hsa051460.73982333
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73657703
99MAPK signaling pathway_Homo sapiens_hsa040100.72810310
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72048346
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.70087417
102Salivary secretion_Homo sapiens_hsa049700.70042623
103Basal cell carcinoma_Homo sapiens_hsa052170.68957097
104MicroRNAs in cancer_Homo sapiens_hsa052060.67844775
105GABAergic synapse_Homo sapiens_hsa047270.67714826
106cAMP signaling pathway_Homo sapiens_hsa040240.67427730
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67325309
108Gastric acid secretion_Homo sapiens_hsa049710.66236207
109Staphylococcus aureus infection_Homo sapiens_hsa051500.65622100
110Circadian rhythm_Homo sapiens_hsa047100.64326335
111Caffeine metabolism_Homo sapiens_hsa002320.64266470
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.63535736
113Serotonergic synapse_Homo sapiens_hsa047260.62747078
114Thyroid cancer_Homo sapiens_hsa052160.61160530
115Tight junction_Homo sapiens_hsa045300.60573759
116Galactose metabolism_Homo sapiens_hsa000520.58878138
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58356107
118Hedgehog signaling pathway_Homo sapiens_hsa043400.57827751
119Fructose and mannose metabolism_Homo sapiens_hsa000510.57110116
120Prion diseases_Homo sapiens_hsa050200.57080284
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56935289
122Oxytocin signaling pathway_Homo sapiens_hsa049210.56752803
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56279607
124Butanoate metabolism_Homo sapiens_hsa006500.56277826
125Dilated cardiomyopathy_Homo sapiens_hsa054140.55249153
126Pancreatic cancer_Homo sapiens_hsa052120.54929295
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.54555711
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54025553
129Prolactin signaling pathway_Homo sapiens_hsa049170.53771956
130mRNA surveillance pathway_Homo sapiens_hsa030150.53509640
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52635687
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52095678
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.51995807
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51684277
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51561549
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51063946
137ECM-receptor interaction_Homo sapiens_hsa045120.50392680
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48478957
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48462620
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.48359965
141One carbon pool by folate_Homo sapiens_hsa006700.48195746
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47251856
143Basal transcription factors_Homo sapiens_hsa030220.46959746
144Thyroid hormone synthesis_Homo sapiens_hsa049180.46807165
145Melanoma_Homo sapiens_hsa052180.46433439
146Amphetamine addiction_Homo sapiens_hsa050310.46275116
147cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45983111
148Insulin secretion_Homo sapiens_hsa049110.45931607
149Prostate cancer_Homo sapiens_hsa052150.44989110
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44383289
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44241316
152Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43826493
153Melanogenesis_Homo sapiens_hsa049160.41720595
154Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38236083
155Arachidonic acid metabolism_Homo sapiens_hsa005900.36154244
156Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35731454
157Retinol metabolism_Homo sapiens_hsa008300.33358751
158Inositol phosphate metabolism_Homo sapiens_hsa005620.33153169
159Dopaminergic synapse_Homo sapiens_hsa047280.32291635
160RNA polymerase_Homo sapiens_hsa030200.32041558
161Alcoholism_Homo sapiens_hsa050340.31725840
162Systemic lupus erythematosus_Homo sapiens_hsa053220.30046840
163Graft-versus-host disease_Homo sapiens_hsa053320.29121335
164Axon guidance_Homo sapiens_hsa043600.27217786
165Ras signaling pathway_Homo sapiens_hsa040140.26941749
166NF-kappa B signaling pathway_Homo sapiens_hsa040640.26566153

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »