TRIM42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.92210114
2motile cilium assembly (GO:0044458)9.72791526
3reproduction (GO:0000003)9.69591114
4spermatid development (GO:0007286)9.63798458
5axonemal dynein complex assembly (GO:0070286)9.50189901
6cilium or flagellum-dependent cell motility (GO:0001539)8.95068512
7regulation of cilium movement (GO:0003352)8.43971822
8cilium movement (GO:0003341)8.03754796
9single fertilization (GO:0007338)7.49067469
10sperm capacitation (GO:0048240)7.48342706
11response to pheromone (GO:0019236)7.46516268
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.37034553
13protein targeting to Golgi (GO:0000042)7.36560652
14microtubule depolymerization (GO:0007019)7.25187727
15piRNA metabolic process (GO:0034587)7.22431638
16negative regulation of inclusion body assembly (GO:0090084)7.21379832
17establishment of protein localization to Golgi (GO:0072600)7.05702019
18male meiosis (GO:0007140)6.94861126
19synaptonemal complex organization (GO:0070193)6.91046620
20retrograde transport, vesicle recycling within Golgi (GO:0000301)6.88808830
21rRNA methylation (GO:0031167)6.84409846
22spermatogenesis (GO:0007283)6.80636781
23male gamete generation (GO:0048232)6.77955237
24synaptonemal complex assembly (GO:0007130)6.69360580
25centriole replication (GO:0007099)6.65141560
26organic cation transport (GO:0015695)6.59826968
27fertilization (GO:0009566)6.26124302
28gamete generation (GO:0007276)6.22460616
29phosphatidylethanolamine biosynthetic process (GO:0006646)5.92186740
30regulation of inclusion body assembly (GO:0090083)5.91600797
31calcium ion-dependent exocytosis (GO:0017156)5.76609314
32rRNA modification (GO:0000154)5.70689943
33spermatid nucleus differentiation (GO:0007289)5.56829643
34phosphatidylethanolamine metabolic process (GO:0046337)5.45968575
35germ cell development (GO:0007281)5.37761580
36cellular process involved in reproduction in multicellular organism (GO:0022412)5.33433146
37glycerol ether metabolic process (GO:0006662)5.26862041
38protein localization to Golgi apparatus (GO:0034067)5.23117994
39ventricular system development (GO:0021591)5.10702609
40regulation of centriole replication (GO:0046599)5.08978778
41regulation of microtubule-based movement (GO:0060632)5.07392109
42cell recognition (GO:0008037)5.04818374
43chromosome condensation (GO:0030261)4.98083886
44multicellular organismal reproductive process (GO:0048609)4.88387304
45ether metabolic process (GO:0018904)4.86348354
46male meiosis I (GO:0007141)4.76620024
47positive regulation of Rab GTPase activity (GO:0032851)4.75150152
48regulation of Rab GTPase activity (GO:0032313)4.75150152
49DNA packaging (GO:0006323)4.70627922
50DNA methylation involved in gamete generation (GO:0043046)4.70277657
51cellular ketone body metabolic process (GO:0046950)4.56618322
52chromosome organization involved in meiosis (GO:0070192)4.52259339
53microtubule severing (GO:0051013)4.40915741
54meiotic nuclear division (GO:0007126)4.33408505
55sexual reproduction (GO:0019953)4.29128894
56left/right pattern formation (GO:0060972)4.26458294
57single strand break repair (GO:0000012)4.24804900
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.15791472
59ketone body metabolic process (GO:1902224)4.01276262
60multicellular organismal development (GO:0007275)4.00631674
61glomerular visceral epithelial cell development (GO:0072015)4.00425722
62seminiferous tubule development (GO:0072520)3.99618193
63histone H3-K9 demethylation (GO:0033169)3.98638637
64chaperone-mediated protein complex assembly (GO:0051131)3.95072111
65microtubule polymerization or depolymerization (GO:0031109)3.94571437
66microtubule nucleation (GO:0007020)3.93116303
67regulation of transcription involved in cell fate commitment (GO:0060850)3.85991928
68glomerular epithelial cell development (GO:0072310)3.77885519
69meiosis I (GO:0007127)3.74527058
70sequestering of actin monomers (GO:0042989)3.73891681
71multicellular organismal movement (GO:0050879)3.72796508
72musculoskeletal movement (GO:0050881)3.72796508
73protein polyglutamylation (GO:0018095)3.52136004
74regulation of meiosis I (GO:0060631)3.51837850
75cellular response to pH (GO:0071467)3.50514254
76response to acidic pH (GO:0010447)3.48113195
77nuclear pore complex assembly (GO:0051292)3.40455108
78protein refolding (GO:0042026)3.37950805
79negative regulation of Rho protein signal transduction (GO:0035024)3.35997406
80meiotic cell cycle (GO:0051321)3.34421184
81cerebral cortex neuron differentiation (GO:0021895)3.32080505
82negative regulation of histone methylation (GO:0031061)3.30410401
83protein K11-linked deubiquitination (GO:0035871)3.28161783
84regulation of spindle checkpoint (GO:0090231)3.20278491
85genitalia morphogenesis (GO:0035112)3.15733238
86protein localization to cilium (GO:0061512)3.14566631
87coenzyme catabolic process (GO:0009109)3.13531961
88membrane protein intracellular domain proteolysis (GO:0031293)3.10526848
89nucleus organization (GO:0006997)3.06948618
90nucleoside diphosphate phosphorylation (GO:0006165)3.04905223
91regulation of histone H3-K9 methylation (GO:0051570)3.04209618
92regulation of interleukin-13 production (GO:0032656)3.04063057
93DNA conformation change (GO:0071103)3.00423474
94amino-acid betaine transport (GO:0015838)3.00365599
95carnitine transport (GO:0015879)3.00365599
96peptidyl-threonine dephosphorylation (GO:0035970)2.97576530
97regulation of female gonad development (GO:2000194)2.97355896
98protein-DNA complex disassembly (GO:0032986)2.96173818
99nucleosome disassembly (GO:0006337)2.96173818
100cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.93459656
101homeostasis of number of cells within a tissue (GO:0048873)2.93080928
102glycolytic process (GO:0006096)2.91384702
103positive regulation of endothelial cell differentiation (GO:0045603)2.90514458
104GTP biosynthetic process (GO:0006183)2.89282248
105centrosome duplication (GO:0051298)2.85472722
106polyamine biosynthetic process (GO:0006596)2.83658522
107interferon-gamma secretion (GO:0072643)2.82329074
108carnitine transmembrane transport (GO:1902603)2.81629468
109alditol metabolic process (GO:0019400)2.79230312
110meiotic cell cycle process (GO:1903046)2.78063422
111axoneme assembly (GO:0035082)2.77420862
112cilium organization (GO:0044782)2.74365502
113RNA localization (GO:0006403)2.73520699
114positive regulation of macrophage activation (GO:0043032)2.73411604
115polyol catabolic process (GO:0046174)2.72769275
116centriole assembly (GO:0098534)2.68441507
117monoubiquitinated protein deubiquitination (GO:0035520)2.66766279
118cilium assembly (GO:0042384)2.66003381
119mitotic sister chromatid cohesion (GO:0007064)2.62674861
120synapsis (GO:0007129)2.61798551
121microtubule-based movement (GO:0007018)2.61343183
122protein depolymerization (GO:0051261)2.60982321
123RNA destabilization (GO:0050779)2.60040533
124cellular component assembly involved in morphogenesis (GO:0010927)2.58672875
125regulation of cilium assembly (GO:1902017)2.57113671
126chromatin silencing (GO:0006342)2.54417907
127UTP biosynthetic process (GO:0006228)2.53836222
128peptidyl-glutamic acid modification (GO:0018200)2.50923857
129cilium morphogenesis (GO:0060271)2.49111592
130intraciliary transport (GO:0042073)2.40994206
131gene silencing by RNA (GO:0031047)2.39577264
132negative regulation of skeletal muscle tissue development (GO:0048642)2.37838922
133sperm motility (GO:0030317)14.3749733
134cell wall macromolecule catabolic process (GO:0016998)13.6149489
135cell wall macromolecule metabolic process (GO:0044036)13.6149489
136fusion of sperm to egg plasma membrane (GO:0007342)13.4742255
137acrosome reaction (GO:0007340)12.3064907
138sperm-egg recognition (GO:0035036)11.5616764
139multicellular organism reproduction (GO:0032504)11.2400889
140acrosome assembly (GO:0001675)10.7435941
141cell-cell recognition (GO:0009988)10.3368141
142plasma membrane fusion (GO:0045026)10.2729980
143binding of sperm to zona pellucida (GO:0007339)10.2226271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.71266538
2EZH2_22144423_ChIP-Seq_EOC_Human4.69787885
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.63350085
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.02062325
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.45148759
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.18615102
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.10381885
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.85751880
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.63269611
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.61695666
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.56720481
12VDR_22108803_ChIP-Seq_LS180_Human2.35950971
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.18317982
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17845793
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07449449
16* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.05454220
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97066097
18GATA1_26923725_Chip-Seq_HPCs_Mouse1.96300729
19* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95671112
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.94768818
21ZNF274_21170338_ChIP-Seq_K562_Hela1.93757023
22DROSHA_22980978_ChIP-Seq_HELA_Human1.90051005
23ERA_21632823_ChIP-Seq_H3396_Human1.85360755
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85151205
25RAC3_21632823_ChIP-Seq_H3396_Human1.79773796
26STAT1_17558387_ChIP-Seq_HELA_Human1.77582556
27* FUS_26573619_Chip-Seq_HEK293_Human1.77216848
28* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77161549
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.76588049
30ELF1_20517297_ChIP-Seq_JURKAT_Human1.76241988
31MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.73107896
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.71874578
33ER_23166858_ChIP-Seq_MCF-7_Human1.70532982
34WDR5_24793694_ChIP-Seq_LNCAP_Human1.69219481
35SOX2_22085726_ChIP-Seq_NPCs_Mouse1.66678322
36TAF2_19829295_ChIP-Seq_ESCs_Human1.61468131
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.60720813
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.60353610
39MYC_19829295_ChIP-Seq_ESCs_Human1.58814270
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.58758373
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.58688188
42* SMAD4_21741376_ChIP-Seq_EPCs_Human1.57923785
43GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.57321383
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.57209227
45AR_25329375_ChIP-Seq_VCAP_Human1.56911669
46* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55625698
47KDM2B_26808549_Chip-Seq_REH_Human1.54100914
48* GATA3_21867929_ChIP-Seq_CD8_Mouse1.52863513
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50598615
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.50054967
51TAL1_26923725_Chip-Seq_HPCs_Mouse1.48158494
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47223998
53BCL6_27268052_Chip-Seq_Bcells_Human1.46797835
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.46465107
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46028952
56CBP_20019798_ChIP-Seq_JUKART_Human1.46028952
57* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44952390
58KAP1_22055183_ChIP-Seq_ESCs_Mouse1.44513014
59CTCF_27219007_Chip-Seq_Bcells_Human1.43965149
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.42565309
61OCT4_20526341_ChIP-Seq_ESCs_Human1.40844760
62P300_19829295_ChIP-Seq_ESCs_Human1.39635018
63BCOR_27268052_Chip-Seq_Bcells_Human1.39212539
64FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39142836
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39015034
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38057877
67LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.37619724
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37301641
69CTCF_20526341_ChIP-Seq_ESCs_Human1.37097920
70SMC4_20622854_ChIP-Seq_HELA_Human1.36834579
71P53_21459846_ChIP-Seq_SAOS-2_Human1.36369369
72HNFA_21074721_ChIP-Seq_CACO-2_Human1.35621357
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35111686
74RBPJ_21746931_ChIP-Seq_IB4_Human1.33882353
75P68_20966046_ChIP-Seq_HELA_Human1.33766532
76E2F1_20622854_ChIP-Seq_HELA_Human1.33321031
77TP63_22573176_ChIP-Seq_HFKS_Human1.33241746
78* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.32532973
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32293666
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.31825947
81PHF8_20622854_ChIP-Seq_HELA_Human1.31673833
82* SMAD3_21741376_ChIP-Seq_EPCs_Human1.31583619
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31533601
84GATA3_21867929_ChIP-Seq_TH1_Mouse1.31134647
85CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30949552
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30304118
87REST_21632747_ChIP-Seq_MESCs_Mouse1.27661957
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26760272
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26688107
90CEBPB_22108803_ChIP-Seq_LS180_Human1.24516862
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.23795349
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23330923
93P300_27268052_Chip-Seq_Bcells_Human1.23178610
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.22837687
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22774979
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22724118
97* SMAD3_21741376_ChIP-Seq_ESCs_Human1.21013151
98P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.20520427
99RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20343135
100TAF15_26573619_Chip-Seq_HEK293_Human1.20309426
101SMRT_27268052_Chip-Seq_Bcells_Human1.20175046
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19402723
103GF1_26923725_Chip-Seq_HPCs_Mouse1.18893301
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18451957
105SMAD4_21799915_ChIP-Seq_A2780_Human1.17585229
106ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17145971
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16749582
108RUNX_20019798_ChIP-Seq_JUKART_Human1.16654564
109* RUNX2_22187159_ChIP-Seq_PCA_Human1.15156212
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14679917
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14229429
112RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13921417
113PHF8_20622853_ChIP-Seq_HELA_Human1.13875131
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12675826
115ESET_19884257_ChIP-Seq_ESCs_Mouse1.12605900
116CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12234443
117* STAT3_23295773_ChIP-Seq_U87_Human1.11922932
118SMAD4_21741376_ChIP-Seq_HESCs_Human1.11487277
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10958230
120CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10640463
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.10537683
122SPI1_26923725_Chip-Seq_HPCs_Mouse1.10485480
123* TP53_18474530_ChIP-ChIP_U2OS_Human1.10110279
124ERG_20517297_ChIP-Seq_VCAP_Human1.08953613
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07683040
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.07638567
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07584802
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07584802
129SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07454836
130OCT4_18555785_Chip-Seq_ESCs_Mouse1.07432857
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06852776
132SOX2_19829295_ChIP-Seq_ESCs_Human1.06303196
133NANOG_19829295_ChIP-Seq_ESCs_Human1.06303196
134SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05803735
135FOXH1_21741376_ChIP-Seq_EPCs_Human1.05800622
136TET1_21451524_ChIP-Seq_MESCs_Mouse1.05078843
137GATA6_21074721_ChIP-Seq_CACO-2_Human1.05043969
138KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04967357
139P53_22387025_ChIP-Seq_ESCs_Mouse1.04375196
140RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04333300
141YY1_22570637_ChIP-Seq_MALME-3M_Human1.04246218
142OCT1_27270436_Chip-Seq_PROSTATE_Human1.04066867
143NFYB_21822215_ChIP-Seq_K562_Human1.04066731
144PRDM14_20953172_ChIP-Seq_ESCs_Human1.03724602
145NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03573712
146MYC_27129775_Chip-Seq_CORNEA_Mouse1.02941939
147HOXB7_26014856_ChIP-Seq_BT474_Human1.02630384
148NANOG_20526341_ChIP-Seq_ESCs_Human1.02477417
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02140876
150E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02118380
151LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02091761
152TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01516450
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01458083
154RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01069149
155OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00197101
156CMYC_18555785_Chip-Seq_ESCs_Mouse1.00130486
157GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99848162
158KLF4_18555785_Chip-Seq_ESCs_Mouse0.99349422
159EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98570542
160SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98272718
161RARA_24833708_ChIP-Seq_LIVER_Mouse0.97803950
162ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96187412
163P300_18555785_Chip-Seq_ESCs_Mouse0.96084591
164PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94577471
165PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94424618
166TBL1_22424771_ChIP-Seq_293T_Human0.93607283
167FLI1_21867929_ChIP-Seq_CD8_Mouse0.93525410
168MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93225786
169* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92748613
170ETV1_20927104_ChIP-Seq_GIST48_Human0.92079854
171SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89647544
172PU1_27457419_Chip-Seq_LIVER_Mouse0.89228632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04167749
2MP0001929_abnormal_gametogenesis5.48871018
3MP0008877_abnormal_DNA_methylation3.86529025
4MP0003718_maternal_effect3.64190148
5MP0002210_abnormal_sex_determination3.40137841
6MP0001348_abnormal_lacrimal_gland3.32043936
7MP0002161_abnormal_fertility/fecundity3.26780474
8MP0001145_abnormal_male_reproductive2.90412282
9MP0005670_abnormal_white_adipose2.82289479
10MP0000653_abnormal_sex_gland2.50496265
11MP0000678_abnormal_parathyroid_gland2.44524519
12MP0002653_abnormal_ependyma_morphology2.16123814
13MP0005410_abnormal_fertilization16.2101928
14MP0003646_muscle_fatigue1.97855895
15MP0005379_endocrine/exocrine_gland_phen1.80909558
16MP0002138_abnormal_hepatobiliary_system1.73212222
17MP0002132_abnormal_respiratory_system1.69234412
18MP0005623_abnormal_meninges_morphology1.60388310
19MP0001486_abnormal_startle_reflex1.52344049
20MP0005395_other_phenotype1.51434223
21MP0003329_amyloid_beta_deposits1.49874261
22MP0005310_abnormal_salivary_gland1.48848171
23MP0002282_abnormal_trachea_morphology1.48775173
24MP0001485_abnormal_pinna_reflex1.48413548
25MP0004233_abnormal_muscle_weight1.34896160
26MP0002160_abnormal_reproductive_system1.32357399
27MP0002249_abnormal_larynx_morphology1.31704971
28MP0005647_abnormal_sex_gland1.18204896
29MP0002234_abnormal_pharynx_morphology1.15268267
30MP0001963_abnormal_hearing_physiology1.13404007
31MP0001765_abnormal_ion_homeostasis1.09000936
32MP0001984_abnormal_olfaction1.05832371
33MP0002127_abnormal_cardiovascular_syste1.03892368
34MP0002735_abnormal_chemical_nociception1.03284488
35MP0006292_abnormal_olfactory_placode1.02286371
36MP0008789_abnormal_olfactory_epithelium1.01196157
37MP0005377_hearing/vestibular/ear_phenot1.00253781
38MP0003878_abnormal_ear_physiology1.00253781
39MP0004859_abnormal_synaptic_plasticity0.97080644
40MP0009053_abnormal_anal_canal0.94888468
41MP0003077_abnormal_cell_cycle0.94244211
42MP0000026_abnormal_inner_ear0.89577622
43MP0002102_abnormal_ear_morphology0.88580937
44MP0009046_muscle_twitch0.87519418
45MP0004510_myositis0.82456418
46MP0005499_abnormal_olfactory_system0.81344785
47MP0005394_taste/olfaction_phenotype0.81344785
48MP0002229_neurodegeneration0.80703567
49MP0002139_abnormal_hepatobiliary_system0.79113960
50MP0000604_amyloidosis0.77700815
51MP0005248_abnormal_Harderian_gland0.76377206
52MP0008058_abnormal_DNA_repair0.73956829
53MP0008995_early_reproductive_senescence0.73721369
54MP0009697_abnormal_copulation0.72345179
55MP0002067_abnormal_sensory_capabilities0.72244422
56MP0005666_abnormal_adipose_tissue0.67767351
57MP0001666_abnormal_nutrient_absorption0.67713589
58MP0001986_abnormal_taste_sensitivity0.67662235
59MP0003011_delayed_dark_adaptation0.65978226
60MP0003115_abnormal_respiratory_system0.64360928
61MP0000955_abnormal_spinal_cord0.63345015
62MP0000049_abnormal_middle_ear0.63009183
63MP0005389_reproductive_system_phenotype0.61742529
64MP0005636_abnormal_mineral_homeostasis0.61384188
65MP0000681_abnormal_thyroid_gland0.60441002
66MP0008875_abnormal_xenobiotic_pharmacok0.59217623
67MP0002272_abnormal_nervous_system0.58886218
68MP0004085_abnormal_heartbeat0.58347138
69MP0001764_abnormal_homeostasis0.57770463
70MP0002733_abnormal_thermal_nociception0.57257002
71MP0003119_abnormal_digestive_system0.57125971
72MP0003252_abnormal_bile_duct0.56579754
73MP0005375_adipose_tissue_phenotype0.56456710
74MP0002557_abnormal_social/conspecific_i0.56364088
75MP0005167_abnormal_blood-brain_barrier0.52119184
76MP0000685_abnormal_immune_system0.51528332
77MP0002909_abnormal_adrenal_gland0.50253722
78MP0002736_abnormal_nociception_after0.50175501
79MP0008569_lethality_at_weaning0.49085837
80MP0003879_abnormal_hair_cell0.47649682
81MP0001879_abnormal_lymphatic_vessel0.45353525
82MP0001905_abnormal_dopamine_level0.45234483
83MP0000751_myopathy0.45022662
84MP0005253_abnormal_eye_physiology0.44838712
85MP0005083_abnormal_biliary_tract0.43288745
86MP0000003_abnormal_adipose_tissue0.42676179
87MP0003693_abnormal_embryo_hatching0.42449898
88MP0005551_abnormal_eye_electrophysiolog0.42348750
89MP0000534_abnormal_ureter_morphology0.41647985
90MP0000566_synostosis0.40941301
91MP0010307_abnormal_tumor_latency0.40918306
92MP0009250_abnormal_appendicular_skeleto0.40562374
93MP0005423_abnormal_somatic_nervous0.39926778
94MP0002734_abnormal_mechanical_nocicepti0.39831973
95MP0009745_abnormal_behavioral_response0.39465679
96MP0000358_abnormal_cell_content/0.38047091
97MP0003942_abnormal_urinary_system0.38016146
98MP0005408_hypopigmentation0.37743478
99MP0001835_abnormal_antigen_presentation0.37698410
100MP0003699_abnormal_female_reproductive0.37437384
101MP0002405_respiratory_system_inflammati0.37267917
102MP0002269_muscular_atrophy0.36870869
103MP0003950_abnormal_plasma_membrane0.36822785
104MP0004036_abnormal_muscle_relaxation0.36313497
105MP0000470_abnormal_stomach_morphology0.36258222
106MP0000230_abnormal_systemic_arterial0.36059472
107MP0003866_abnormal_defecation0.35755426
108MP0002928_abnormal_bile_duct0.35218512
109MP0003633_abnormal_nervous_system0.34874790
110MP0001968_abnormal_touch/_nociception0.34471891
111MP0001501_abnormal_sleep_pattern0.34455269
112MP0004742_abnormal_vestibular_system0.34184598
113MP0001970_abnormal_pain_threshold0.34103432
114MP0001324_abnormal_eye_pigmentation0.32525216
115MP0005367_renal/urinary_system_phenotyp0.31738564
116MP0000516_abnormal_urinary_system0.31738564
117MP0003137_abnormal_impulse_conducting0.31185893
118MP0003045_fibrosis0.31112310
119MP0006072_abnormal_retinal_apoptosis0.31093761
120MP0000015_abnormal_ear_pigmentation0.31085560
121MP0001119_abnormal_female_reproductive0.30320255
122MP0005645_abnormal_hypothalamus_physiol0.29633036
123MP0010094_abnormal_chromosome_stability0.29239821
124MP0006082_CNS_inflammation0.28972753
125MP0002971_abnormal_brown_adipose0.28266397
126MP0001293_anophthalmia0.26783380
127MP0003111_abnormal_nucleus_morphology0.26005862
128MP0004019_abnormal_vitamin_homeostasis0.25296586
129MP0003959_abnormal_lean_body0.24982623
130MP0009115_abnormal_fat_cell0.24904338
131MP0010352_gastrointestinal_tract_polyps0.24688976
132MP0005535_abnormal_body_temperature0.24631331
133MP0006036_abnormal_mitochondrial_physio0.24545667
134MP0005397_hematopoietic_system_phenotyp0.24149392
135MP0001545_abnormal_hematopoietic_system0.24149392
136MP0004133_heterotaxia0.24014055
137MP0005391_vision/eye_phenotype0.22902057
138MP0003861_abnormal_nervous_system0.22546213
139MP0001440_abnormal_grooming_behavior0.22132480
140MP0000569_abnormal_digit_pigmentation0.21996056
141MP0003631_nervous_system_phenotype0.21404305
142MP0002169_no_abnormal_phenotype0.21374223
143MP0009278_abnormal_bone_marrow0.21366097
144MP0002873_normal_phenotype0.21063385
145MP0005503_abnormal_tendon_morphology0.20547293
146MP0004811_abnormal_neuron_physiology0.19565299
147MP0002152_abnormal_brain_morphology0.19501582
148MP0002572_abnormal_emotion/affect_behav0.18658099
149MP0003936_abnormal_reproductive_system0.18445488
150MP0003632_abnormal_nervous_system0.18266617
151MP0005451_abnormal_body_composition0.17087603
152MP0002693_abnormal_pancreas_physiology0.16938411
153MP0002108_abnormal_muscle_morphology0.16613711
154MP0002822_catalepsy0.15609169
155MP0009780_abnormal_chondrocyte_physiolo0.15349094
156MP0003786_premature_aging0.15339833
157MP0002295_abnormal_pulmonary_circulatio0.15126160
158MP0002109_abnormal_limb_morphology0.15097488

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.14511422
2Abnormal respiratory motile cilium morphology (HP:0005938)9.14511422
3Abnormal respiratory motile cilium physiology (HP:0012261)9.07792643
4Severe visual impairment (HP:0001141)7.57787230
5Abnormal ciliary motility (HP:0012262)7.29959808
6Rhinitis (HP:0012384)7.20666667
7Chronic bronchitis (HP:0004469)6.79218613
8Infertility (HP:0000789)6.64408812
9Nasal polyposis (HP:0100582)6.63150461
10Chronic hepatic failure (HP:0100626)5.43223607
11Abnormality of the nasal mucosa (HP:0000433)5.40382258
12Attenuation of retinal blood vessels (HP:0007843)4.70669603
13Bronchitis (HP:0012387)4.68310359
14Male infertility (HP:0003251)4.66758264
15Bony spicule pigmentary retinopathy (HP:0007737)4.63622625
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.55818639
17Bronchiectasis (HP:0002110)4.51621018
18Hyperkalemia (HP:0002153)4.47781084
19Resting tremor (HP:0002322)4.36249060
20Cone-rod dystrophy (HP:0000548)4.29577570
21Abnormality of macular pigmentation (HP:0008002)3.95707542
22Aplasia/Hypoplasia of the earlobes (HP:0009906)3.85996985
23Abnormal spermatogenesis (HP:0008669)3.83492488
24Nephronophthisis (HP:0000090)3.72946564
25Progressive sensorineural hearing impairment (HP:0000408)3.39498918
26Facial shape deformation (HP:0011334)3.39463808
27Potter facies (HP:0002009)3.39463808
28Truncal obesity (HP:0001956)3.36605483
29Recurrent otitis media (HP:0000403)3.35557256
30Recurrent sinusitis (HP:0011108)3.34994075
31Hypoalphalipoproteinemia (HP:0003233)3.33486655
32Hypoplasia of the thymus (HP:0000778)3.28455689
33Recurrent bronchitis (HP:0002837)3.27704856
34Abnormal rod and cone electroretinograms (HP:0008323)3.26035490
35Menstrual irregularities (HP:0000858)3.23373374
36Enlarged epiphyses (HP:0010580)3.20633751
37Osteomalacia (HP:0002749)3.15034409
38Postural instability (HP:0002172)2.95498863
39Hypoplastic ischia (HP:0003175)2.92573435
40Abnormality of dental color (HP:0011073)2.87017645
41Progressive cerebellar ataxia (HP:0002073)2.86538759
42Amelogenesis imperfecta (HP:0000705)2.86346633
43Abnormality of the renal medulla (HP:0100957)2.81480038
44Portal hypertension (HP:0001409)2.81407635
45Generalized aminoaciduria (HP:0002909)2.81221987
46Renovascular hypertension (HP:0100817)2.80353300
47Insulin-resistant diabetes mellitus (HP:0000831)2.71333872
48Impulsivity (HP:0100710)2.68753151
49Abnormality of the ischium (HP:0003174)2.59428809
50Abnormality of the hepatic vasculature (HP:0006707)2.56946562
51Tubulointerstitial nephritis (HP:0001970)2.52366712
52Hypophosphatemic rickets (HP:0004912)2.50066153
53Abnormality of potassium homeostasis (HP:0011042)2.46449956
54Abnormal urine output (HP:0012590)2.45946067
55Medial flaring of the eyebrow (HP:0010747)2.44080890
56Azoospermia (HP:0000027)2.42546453
57Unilateral renal agenesis (HP:0000122)2.40553594
58Horizontal nystagmus (HP:0000666)2.38542572
59Abnormal gallbladder physiology (HP:0012438)2.38534448
60Cholecystitis (HP:0001082)2.38534448
61Abnormality of the costochondral junction (HP:0000919)2.35355975
62Tubular atrophy (HP:0000092)2.29232322
63Gonadotropin excess (HP:0000837)2.25563882
64Intellectual disability, moderate (HP:0002342)2.25340953
65Subcapsular cataract (HP:0000523)2.21941385
66Hyperuricemia (HP:0002149)2.21397257
67Increased purine levels (HP:0004368)2.21397257
68Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.18824477
69Myokymia (HP:0002411)2.17494649
70Progressive hearing impairment (HP:0001730)2.16210513
71Abnormality of midbrain morphology (HP:0002418)2.15333351
72Molar tooth sign on MRI (HP:0002419)2.15333351
73Abnormality of the aortic arch (HP:0012303)2.09754821
74Tubulointerstitial abnormality (HP:0001969)2.07678876
75Dyschromatopsia (HP:0007641)2.06538681
76Optic nerve hypoplasia (HP:0000609)2.03823378
77Focal segmental glomerulosclerosis (HP:0000097)2.03197785
78Heterotopia (HP:0002282)2.02765914
79Absent/shortened dynein arms (HP:0200106)13.2772883
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.2772883
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.4250137
82Ventricular tachycardia (HP:0004756)1.98938925
83Polyuria (HP:0000103)1.96866526
84Congenital sensorineural hearing impairment (HP:0008527)1.91749510
85Hyponatremia (HP:0002902)1.90510654
86Abnormality of abdominal situs (HP:0011620)1.88030191
87Abdominal situs inversus (HP:0003363)1.88030191
88Short femoral neck (HP:0100864)1.87651692
89Abnormality of the parathyroid morphology (HP:0011766)1.86243172
90Spastic tetraparesis (HP:0001285)1.85614385
91Choroideremia (HP:0001139)1.83370385
92Double outlet right ventricle (HP:0001719)1.83348286
93Congenital malformation of the right heart (HP:0011723)1.83348286
94Recurrent pneumonia (HP:0006532)1.82617468
95Fibular hypoplasia (HP:0003038)1.82482944
96Decreased central vision (HP:0007663)1.81420416
97Photophobia (HP:0000613)1.79911694
98Type 2 muscle fiber atrophy (HP:0003554)1.79621543
99Widely patent fontanelles and sutures (HP:0004492)1.77556160
100Chronic sinusitis (HP:0011109)1.76062068
101Stomatitis (HP:0010280)1.75933444
102Anterior segment dysgenesis (HP:0007700)1.75919222
103Metaphyseal cupping (HP:0003021)1.75481399
104Sandal gap (HP:0001852)1.73054350
105Bile duct proliferation (HP:0001408)1.72561319
106Abnormal biliary tract physiology (HP:0012439)1.72561319
107Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69230774
108Increased IgM level (HP:0003496)1.67367911
109Renal Fanconi syndrome (HP:0001994)1.65637288
110Short ribs (HP:0000773)1.65570917
111Epiphyseal dysplasia (HP:0002656)1.65263976
112Abnormality of the neuromuscular junction (HP:0003398)1.65075354
113Fatigable weakness (HP:0003473)1.65075354
114Asymmetric septal hypertrophy (HP:0001670)1.61114797
115Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.60501301
116Tubulointerstitial fibrosis (HP:0005576)1.60182364
117Absent epiphyses (HP:0010577)1.60088734
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.60088734
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59812470
120Stage 5 chronic kidney disease (HP:0003774)1.59595253
121Aplasia/Hypoplasia of the lens (HP:0008063)1.59588797
122Glomerulosclerosis (HP:0000096)1.58789537
123Hypoalbuminemia (HP:0003073)1.58669423
124Abnormal albumin level (HP:0012116)1.58669423
125Postaxial foot polydactyly (HP:0001830)1.57602574
126Easy fatigability (HP:0003388)1.56539677
127Sensory axonal neuropathy (HP:0003390)1.52673980
128Neurofibrillary tangles (HP:0002185)1.51790114
129Metaphyseal dysplasia (HP:0100255)1.48229260
130Supernumerary spleens (HP:0009799)1.48133255
131Abnormality of the epiphysis of the femoral head (HP:0010574)1.47305967
132Renal dysplasia (HP:0000110)1.45882307
133Muscle fiber atrophy (HP:0100295)1.45564685
134Gait imbalance (HP:0002141)1.43916225
135Abnormality of the renal cortex (HP:0011035)1.42987608
136Congenital primary aphakia (HP:0007707)1.42023568
137Decreased electroretinogram (ERG) amplitude (HP:0000654)1.41763101
138Hemorrhage of the eye (HP:0011885)1.41759682
139Bundle branch block (HP:0011710)1.41543085
140Aplasia/hypoplasia of the femur (HP:0005613)1.40325621
141Abnormality of femoral epiphyses (HP:0006499)1.40166094
142Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.40166094
143Polydipsia (HP:0001959)1.39139315
144Abnormal drinking behavior (HP:0030082)1.39139315
145Short thorax (HP:0010306)1.38692102
146Short tibia (HP:0005736)1.38581573
147Bell-shaped thorax (HP:0001591)1.36871017
148Abnormality of renal excretion (HP:0011036)1.36799884
149Congenital hepatic fibrosis (HP:0002612)1.35239851
150Aplasia/Hypoplasia of the tibia (HP:0005772)1.33949094
151Postaxial hand polydactyly (HP:0001162)1.33480374
152Irregular vertebral endplates (HP:0003301)1.33316277
153Abnormality of the femoral head (HP:0003368)1.26275181
154Mild short stature (HP:0003502)1.25935756
155Amyotrophic lateral sclerosis (HP:0007354)1.25135359
156Flattened epiphyses (HP:0003071)1.24986725
157Cerebellar dysplasia (HP:0007033)1.24216133
158Loss of speech (HP:0002371)1.23757861
159Oculomotor apraxia (HP:0000657)1.21671177
160Weak cry (HP:0001612)1.20126505
161Hypercholesterolemia (HP:0003124)1.19237405
162Abnormality of permanent molar morphology (HP:0011071)1.18738243
163Abnormality of the dental root (HP:0006486)1.18738243
164Taurodontia (HP:0000679)1.18738243
165Nephrogenic diabetes insipidus (HP:0009806)1.18055437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.83187829
2PDK37.83187829
3TESK16.85020233
4PDK25.26899431
5PRKD35.26701391
6ICK4.24858313
7INSRR4.12116622
8BRD43.66605071
9PLK23.47579249
10MAP4K22.84412206
11WNK42.67824200
12STK392.26291327
13PTK2B1.74548341
14STK381.68327185
15DYRK1B1.66996579
16TESK21.66476001
17PNCK1.59656352
18MST1R1.46408774
19CDK71.40315549
20MET1.39895600
21NEK21.31225202
22KSR21.22777934
23PDK11.13014044
24MAP3K130.98642688
25WNK10.83707667
26CAMK1D0.77789407
27DYRK30.75281167
28AKT30.73886525
29IRAK10.72862445
30MAP3K120.66927513
31RIPK40.66332648
32PDPK10.65394644
33TTK0.64335562
34TIE10.64033239
35MAPK150.62276781
36LMTK20.58776398
37CAMK10.58721822
38PASK0.58609976
39LATS20.56443378
40SIK20.56148925
41PBK0.55604168
42TYRO30.55304002
43LATS10.54969473
44PRKAA20.53304451
45MAP2K60.53119425
46CHEK20.51969492
47MAP3K80.50913544
48CDK20.50108695
49MAP2K20.49465702
50STK38L0.49323098
51MUSK0.48844520
52ROCK10.46079918
53CDK10.44844814
54STK30.43057585
55PIK3CG0.41810859
56MAP3K20.40901192
57OXSR10.40812729
58MAPK10.40513236
59BRSK10.40397812
60RPS6KA20.40361907
61NTRK30.39329265
62CDK30.37783098
63BRAF0.37000579
64BMPR1B0.36904818
65UHMK10.36725495
66MOS0.36604414
67PRKCG0.36004557
68AURKA0.35501827
69CCNB10.34841366
70NTRK20.34734874
71PAK10.34689767
72CAMK1G0.33839499
73EIF2AK10.33300776
74SGK2230.32002142
75SGK4940.32002142
76IRAK20.31626390
77SGK10.30729801
78CDK190.30567106
79PLK40.30077876
80EEF2K0.28625824
81CDK90.27395476
82PRKG20.27168512
83MAP3K100.27091611
84CAMKK10.26767307
85CAMK40.26310717
86PAK40.25878182
87CSF1R0.25760494
88MAP3K40.25653412
89PINK10.25422016
90CHEK10.25021942
91ZAP700.24908874
92CDK40.24429924
93PRKCQ0.23771262
94MAP4K10.23255512
95TXK0.22703542
96LIMK10.22349943
97TNIK0.21095211
98ARAF0.20636555
99MAPK100.19750627
100PRKAA10.19551087
101PIM20.19258245
102MAPK140.18696289
103TAOK10.18515404
104MTOR0.18366638
105TAOK30.17852254
106MAP3K90.17060212
107ATM0.16831595
108PAK20.16151745
109MARK20.15971044
110WNK30.15937147
111MAPK110.15921600
112PRKCB0.13510921
113BRSK20.12652450
114PRKACB0.12519151
115AKT10.12325498
116MAPKAPK50.11992272
117SGK20.11780655
118PLK10.11734627
119PKN10.11598367
120RPS6KL10.11596851
121RPS6KC10.11596851
122PTK60.11039724
123MAP3K50.10991351
124NEK60.10968567
125PRKG10.10786244
126BLK0.10623576
127MARK10.10447751
128CLK10.10180630
129RPS6KA60.10137104
130NUAK10.09876401
131ATR0.09866886
132PRKCZ0.09590008
133CAMK2A0.08647189
134WEE10.08431670
135CDK150.08418963
136MAP3K110.08418439
137MAP3K10.08408796
138PRKCA0.07112862
139CSNK2A10.06946919
140BUB10.06929909
141CDK11A0.06484508
142PRKCD0.05639239
143CDK180.05545744
144CSNK1D0.05538787
145STK110.05349355
146RPS6KB10.05288804
147YES10.04940740
148MYLK0.03639062
149PRKACG0.03609073
150RPS6KA10.03534669
151DDR20.03368985
152MAPK80.03229280
153CDK120.03021642
154CSNK2A20.02660874
155GSK3B0.02563925

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.85619609
2Fatty acid biosynthesis_Homo sapiens_hsa000614.94558975
3Olfactory transduction_Homo sapiens_hsa047404.17498380
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.10191416
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.06055439
6Linoleic acid metabolism_Homo sapiens_hsa005913.04850276
7Vitamin B6 metabolism_Homo sapiens_hsa007502.91775735
8Pyruvate metabolism_Homo sapiens_hsa006202.86179323
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.78811229
10Basal transcription factors_Homo sapiens_hsa030222.49892409
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.41295447
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.40792135
13Glucagon signaling pathway_Homo sapiens_hsa049222.32270181
14Propanoate metabolism_Homo sapiens_hsa006402.31394441
15Butanoate metabolism_Homo sapiens_hsa006502.14658784
16Glycerolipid metabolism_Homo sapiens_hsa005611.95942200
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.94415033
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.88898378
19PPAR signaling pathway_Homo sapiens_hsa033201.82648922
20Pentose phosphate pathway_Homo sapiens_hsa000301.80759389
21Selenocompound metabolism_Homo sapiens_hsa004501.80292925
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79097574
23Fructose and mannose metabolism_Homo sapiens_hsa000511.63781544
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.60554445
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52764144
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.52626616
27Mineral absorption_Homo sapiens_hsa049781.52494283
28Fat digestion and absorption_Homo sapiens_hsa049751.52468190
29Oocyte meiosis_Homo sapiens_hsa041141.51983775
30Ether lipid metabolism_Homo sapiens_hsa005651.50248785
31Fatty acid metabolism_Homo sapiens_hsa012121.46731825
32Cardiac muscle contraction_Homo sapiens_hsa042601.46004401
33Type II diabetes mellitus_Homo sapiens_hsa049301.45757539
34Fatty acid degradation_Homo sapiens_hsa000711.43601623
35Type I diabetes mellitus_Homo sapiens_hsa049401.43472656
36Amphetamine addiction_Homo sapiens_hsa050311.42962646
37Phenylalanine metabolism_Homo sapiens_hsa003601.42128304
38Phototransduction_Homo sapiens_hsa047441.37844203
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35280251
40Antigen processing and presentation_Homo sapiens_hsa046121.29367400
41Graft-versus-host disease_Homo sapiens_hsa053321.24097787
42Dorso-ventral axis formation_Homo sapiens_hsa043201.23822520
43Asthma_Homo sapiens_hsa053101.13344269
44Huntingtons disease_Homo sapiens_hsa050161.10361176
45Hedgehog signaling pathway_Homo sapiens_hsa043401.08458576
46Carbon metabolism_Homo sapiens_hsa012001.08408763
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07677717
48Allograft rejection_Homo sapiens_hsa053301.05366718
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03881682
50Nicotine addiction_Homo sapiens_hsa050331.03579334
51Morphine addiction_Homo sapiens_hsa050321.01611435
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01274048
53Arachidonic acid metabolism_Homo sapiens_hsa005901.00882877
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00119102
55Fanconi anemia pathway_Homo sapiens_hsa034600.99541385
56Arginine and proline metabolism_Homo sapiens_hsa003300.99358328
57Protein digestion and absorption_Homo sapiens_hsa049740.98875758
58Purine metabolism_Homo sapiens_hsa002300.97260124
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93459565
60Renin secretion_Homo sapiens_hsa049240.93100289
61Influenza A_Homo sapiens_hsa051640.90975747
62Bile secretion_Homo sapiens_hsa049760.89454071
63Arginine biosynthesis_Homo sapiens_hsa002200.85188467
64Chemical carcinogenesis_Homo sapiens_hsa052040.82938965
65mRNA surveillance pathway_Homo sapiens_hsa030150.82648337
66Insulin secretion_Homo sapiens_hsa049110.81639859
67ABC transporters_Homo sapiens_hsa020100.80335855
68Autoimmune thyroid disease_Homo sapiens_hsa053200.79374152
69Collecting duct acid secretion_Homo sapiens_hsa049660.78340700
70Thyroid hormone synthesis_Homo sapiens_hsa049180.77456899
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.74381370
72Biosynthesis of amino acids_Homo sapiens_hsa012300.73764236
73Taste transduction_Homo sapiens_hsa047420.73615094
74Glutathione metabolism_Homo sapiens_hsa004800.72848833
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.70579982
76Systemic lupus erythematosus_Homo sapiens_hsa053220.68494823
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65754358
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.65218426
79Glutamatergic synapse_Homo sapiens_hsa047240.64980419
80Other glycan degradation_Homo sapiens_hsa005110.64979173
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.60672940
82Cell cycle_Homo sapiens_hsa041100.60109372
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59235674
84RNA transport_Homo sapiens_hsa030130.59076070
85Pancreatic secretion_Homo sapiens_hsa049720.58011240
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57477484
87Salivary secretion_Homo sapiens_hsa049700.57111560
88Inositol phosphate metabolism_Homo sapiens_hsa005620.57076116
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56643881
90Long-term potentiation_Homo sapiens_hsa047200.55967616
91Serotonergic synapse_Homo sapiens_hsa047260.54928025
92Estrogen signaling pathway_Homo sapiens_hsa049150.54289302
93Tyrosine metabolism_Homo sapiens_hsa003500.53175335
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52252622
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52026759
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51593904
97Primary immunodeficiency_Homo sapiens_hsa053400.51588275
98Retinol metabolism_Homo sapiens_hsa008300.51434679
99MAPK signaling pathway_Homo sapiens_hsa040100.49152303
100Calcium signaling pathway_Homo sapiens_hsa040200.48196578
101Legionellosis_Homo sapiens_hsa051340.47934779
102Synaptic vesicle cycle_Homo sapiens_hsa047210.46711036
103Base excision repair_Homo sapiens_hsa034100.44696508
104Gastric acid secretion_Homo sapiens_hsa049710.44038066
105Metabolic pathways_Homo sapiens_hsa011000.43022672
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.41428129
107GABAergic synapse_Homo sapiens_hsa047270.41266348
108Viral myocarditis_Homo sapiens_hsa054160.39977225
109Cocaine addiction_Homo sapiens_hsa050300.38538657
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37878578
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37854240
112cAMP signaling pathway_Homo sapiens_hsa040240.37428661
113Acute myeloid leukemia_Homo sapiens_hsa052210.35872759
114T cell receptor signaling pathway_Homo sapiens_hsa046600.35669695
115Renin-angiotensin system_Homo sapiens_hsa046140.35497678
116Herpes simplex infection_Homo sapiens_hsa051680.35472972
117VEGF signaling pathway_Homo sapiens_hsa043700.35270674
118Malaria_Homo sapiens_hsa051440.32226003
119N-Glycan biosynthesis_Homo sapiens_hsa005100.31806216
120Caffeine metabolism_Homo sapiens_hsa002320.31261330
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31116746
122Circadian entrainment_Homo sapiens_hsa047130.31080544
123Tight junction_Homo sapiens_hsa045300.30623759
124Oxytocin signaling pathway_Homo sapiens_hsa049210.30364877
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30302110
126Cholinergic synapse_Homo sapiens_hsa047250.30224201
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28764147
128Endocytosis_Homo sapiens_hsa041440.27947331
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.27463440
130Viral carcinogenesis_Homo sapiens_hsa052030.27110830
131Toxoplasmosis_Homo sapiens_hsa051450.25400579
132mTOR signaling pathway_Homo sapiens_hsa041500.24065348
133Circadian rhythm_Homo sapiens_hsa047100.22570758
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.22439833
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21743833
136Adherens junction_Homo sapiens_hsa045200.21734128
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21665017
138Sulfur metabolism_Homo sapiens_hsa009200.18967852
139B cell receptor signaling pathway_Homo sapiens_hsa046620.18369848
140AMPK signaling pathway_Homo sapiens_hsa041520.18277613
141Alcoholism_Homo sapiens_hsa050340.15004747
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.14182860

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