TRIM43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oocyte development (GO:0048599)8.25339860
2histone lysine demethylation (GO:0070076)7.29455066
3histone demethylation (GO:0016577)6.90421924
4multicellular organism reproduction (GO:0032504)6.73301110
5regulation of exit from mitosis (GO:0007096)6.65652740
6synaptonemal complex organization (GO:0070193)6.48209518
7regulation of RIG-I signaling pathway (GO:0039535)6.30589532
8regulation of acrosome reaction (GO:0060046)6.23623674
9protein dealkylation (GO:0008214)6.23259605
10protein demethylation (GO:0006482)6.23259605
11synaptonemal complex assembly (GO:0007130)6.22124057
12positive regulation of meiosis (GO:0045836)5.98762628
13positive regulation of meiotic cell cycle (GO:0051446)5.75923929
14positive regulation of uterine smooth muscle contraction (GO:0070474)5.61887464
15gonadal mesoderm development (GO:0007506)5.59152063
16regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)5.51993184
17positive regulation of catecholamine secretion (GO:0033605)5.51614465
18male meiosis I (GO:0007141)5.43581795
19N-terminal protein amino acid acetylation (GO:0006474)5.40747638
20negative regulation of Ras GTPase activity (GO:0034261)5.30617462
21regulation of alternative mRNA splicing, via spliceosome (GO:0000381)5.25335146
22regulation of female receptivity (GO:0045924)4.99642528
23regulation of cytokine production involved in inflammatory response (GO:1900015)4.94250199
24single fertilization (GO:0007338)4.69966766
25male meiosis (GO:0007140)4.55121132
26acrosome reaction (GO:0007340)4.47981703
27reproduction (GO:0000003)4.46779650
28meiosis I (GO:0007127)4.44435545
29regulation of uterine smooth muscle contraction (GO:0070472)4.35897250
30binding of sperm to zona pellucida (GO:0007339)4.30681120
31female mating behavior (GO:0060180)4.28249240
32protein K48-linked deubiquitination (GO:0071108)4.10901269
33aggressive behavior (GO:0002118)3.98246018
34protein kinase C signaling (GO:0070528)3.97540062
35chromosome organization involved in meiosis (GO:0070192)3.92405036
36response to UV-C (GO:0010225)3.88508451
37drinking behavior (GO:0042756)3.82992935
38protein K6-linked ubiquitination (GO:0085020)3.73671552
39positive regulation of digestive system process (GO:0060456)3.66566742
40positive regulation of histone H3-K4 methylation (GO:0051571)3.63622190
41regulation of meiosis (GO:0040020)3.62697567
42fertilization (GO:0009566)3.60959354
43regulation of penile erection (GO:0060405)3.59086165
44negative regulation of reproductive process (GO:2000242)3.57022349
45regulation of helicase activity (GO:0051095)3.53507785
46positive regulation of prostaglandin secretion (GO:0032308)3.48602637
47maturation of SSU-rRNA (GO:0030490)3.43866491
48hyperosmotic salinity response (GO:0042538)3.41696632
49regulation of histone H3-K9 methylation (GO:0051570)3.40834316
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.40525298
51regulation of female gonad development (GO:2000194)3.40373117
52negative regulation of digestive system process (GO:0060457)3.39180410
53intestinal epithelial cell development (GO:0060576)3.38454798
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.38201262
55positive regulation of humoral immune response (GO:0002922)3.35321612
56centriole replication (GO:0007099)3.32305263
57regulation of mRNA splicing, via spliceosome (GO:0048024)3.31502792
58sleep (GO:0030431)3.31330623
59sperm-egg recognition (GO:0035036)3.29090169
60meiotic cell cycle process (GO:1903046)3.25270497
61demethylation (GO:0070988)3.23726285
62citrulline biosynthetic process (GO:0019240)3.16983350
63piRNA metabolic process (GO:0034587)3.16261853
64protein K63-linked deubiquitination (GO:0070536)3.11503707
65regulation of ruffle assembly (GO:1900027)3.10859557
66meiotic cell cycle (GO:0051321)3.10213099
67calcium ion-dependent exocytosis (GO:0017156)3.05746897
68RNA localization (GO:0006403)3.03014161
69poly(A)+ mRNA export from nucleus (GO:0016973)3.01076270
70regulation of defense response to virus by host (GO:0050691)3.00178781
71positive regulation of reproductive process (GO:2000243)2.97840488
72regulation of meiotic cell cycle (GO:0051445)2.97362414
73positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.96347503
74transcription from mitochondrial promoter (GO:0006390)2.88730137
75negative regulation of histone modification (GO:0031057)2.88359778
76regulation of mRNA processing (GO:0050684)2.87916223
77striated muscle atrophy (GO:0014891)2.86594404
78phosphate ion homeostasis (GO:0055062)2.86201400
79trivalent inorganic anion homeostasis (GO:0072506)2.86201400
80regulation of prostaglandin secretion (GO:0032306)2.84182250
81epithelial cilium movement (GO:0003351)2.83933515
82mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.82815409
83maternal behavior (GO:0042711)2.82706245
84mitotic metaphase plate congression (GO:0007080)2.82612930
85negative regulation of smooth muscle cell differentiation (GO:0051151)2.76215363
86spermatid development (GO:0007286)2.75798608
87regulation of DNA endoreduplication (GO:0032875)2.75486401
88N-terminal protein amino acid modification (GO:0031365)2.74753131
89response to prostaglandin (GO:0034694)2.74749781
90regulation of DNA methylation (GO:0044030)2.74285189
91cilium movement (GO:0003341)2.74132223
92mitochondrial RNA metabolic process (GO:0000959)2.72369375
93exocrine pancreas development (GO:0031017)2.70299362
94DNA replication-dependent nucleosome assembly (GO:0006335)2.65596449
95DNA replication-dependent nucleosome organization (GO:0034723)2.65596449
96cell-cell recognition (GO:0009988)2.64804355
97meiotic nuclear division (GO:0007126)2.64329856
98histone H3-K9 demethylation (GO:0033169)18.2115748
99negative regulation of retinoic acid receptor signaling pathway (GO:0048387)17.5504077
100regulation of retinoic acid receptor signaling pathway (GO:0048385)14.6683282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse9.14750739
2EZH2_22144423_ChIP-Seq_EOC_Human5.68422387
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.68577478
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.73817612
5VDR_22108803_ChIP-Seq_LS180_Human3.43154140
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.02947802
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.85640749
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.81360511
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67293719
10GBX2_23144817_ChIP-Seq_PC3_Human2.48805771
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46205240
12IGF1R_20145208_ChIP-Seq_DFB_Human2.30914483
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.29806860
14E2F7_22180533_ChIP-Seq_HELA_Human2.19099407
15IRF1_19129219_ChIP-ChIP_H3396_Human2.17826945
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.17706454
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12428080
18AUTS2_25519132_ChIP-Seq_293T-REX_Human2.10872970
19AR_21909140_ChIP-Seq_LNCAP_Human2.09519498
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07464891
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94125382
22TOP2B_26459242_ChIP-Seq_MCF-7_Human1.87200042
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81363658
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78686752
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78686752
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78686752
27MYC_18940864_ChIP-ChIP_HL60_Human1.76616524
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76436462
29PRDM14_20953172_ChIP-Seq_ESCs_Human1.76246942
30TCF4_23295773_ChIP-Seq_U87_Human1.67764153
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64169092
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63961210
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63353185
34RNF2_27304074_Chip-Seq_NSC_Mouse1.63048910
35CBP_21632823_ChIP-Seq_H3396_Human1.62209390
36SMAD4_21799915_ChIP-Seq_A2780_Human1.60047859
37RXR_22108803_ChIP-Seq_LS180_Human1.54711513
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51358829
39TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.50207176
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46222269
41STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.44753940
42STAT3_23295773_ChIP-Seq_U87_Human1.42620333
43SMAD3_21741376_ChIP-Seq_HESCs_Human1.41042328
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.40705838
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38928273
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37691924
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37111692
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35515402
49SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.35444462
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.34873500
51NCOR_22424771_ChIP-Seq_293T_Human1.34204620
52P300_19829295_ChIP-Seq_ESCs_Human1.34052236
53TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32363859
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32038187
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.31011752
56GF1_26923725_Chip-Seq_HPCs_Mouse1.29821088
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.29603555
58SMAD4_21741376_ChIP-Seq_HESCs_Human1.29117011
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.28193422
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.27994047
61GATA3_26560356_Chip-Seq_TH1_Human1.27608443
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22060027
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21361969
64TAF15_26573619_Chip-Seq_HEK293_Human1.21187308
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.19838643
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19786465
67ZNF274_21170338_ChIP-Seq_K562_Hela1.19095530
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16877237
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15732204
70TCF4_22108803_ChIP-Seq_LS180_Human1.15675185
71RUNX2_22187159_ChIP-Seq_PCA_Human1.13450366
72TTF2_22483619_ChIP-Seq_HELA_Human1.12929108
73BCAT_22108803_ChIP-Seq_LS180_Human1.10805806
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10018821
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09954775
76KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05677170
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05568512
78RAC3_21632823_ChIP-Seq_H3396_Human1.04983377
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02219462
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00085075
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99248616
82GABP_17652178_ChIP-ChIP_JURKAT_Human0.98430542
83PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97981857
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97883139
85* AR_25329375_ChIP-Seq_VCAP_Human0.97878819
86EZH2_27294783_Chip-Seq_ESCs_Mouse0.94125344
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93825761
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93750943
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93175992
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93155173
91CBX2_27304074_Chip-Seq_ESCs_Mouse0.91757749
92ESET_19884257_ChIP-Seq_ESCs_Mouse0.90966512
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90704976
94FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87598879
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87591293
96AR_21572438_ChIP-Seq_LNCaP_Human0.87327757
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87294415
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86426413
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.85885158
100TP53_22573176_ChIP-Seq_HFKS_Human0.85407752

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.29027682
2MP0003283_abnormal_digestive_organ4.92481419
3MP0009379_abnormal_foot_pigmentation4.18881475
4MP0003950_abnormal_plasma_membrane3.94943662
5MP0003693_abnormal_embryo_hatching3.75612047
6MP0000678_abnormal_parathyroid_gland3.73885212
7MP0002160_abnormal_reproductive_system3.37345431
8MP0005410_abnormal_fertilization3.11866422
9MP0003136_yellow_coat_color2.94149944
10MP0009840_abnormal_foam_cell2.89085124
11MP0001929_abnormal_gametogenesis2.54049453
12MP0006276_abnormal_autonomic_nervous2.52121719
13MP0000427_abnormal_hair_cycle2.49222494
14MP0008058_abnormal_DNA_repair2.47881540
15MP0005360_urolithiasis2.32770900
16MP0001502_abnormal_circadian_rhythm2.29355619
17MP0002210_abnormal_sex_determination2.21365160
18MP0003699_abnormal_female_reproductive2.02546363
19MP0005220_abnormal_exocrine_pancreas1.98259238
20MP0003119_abnormal_digestive_system1.93112349
21MP0003718_maternal_effect1.88354867
22MP0010094_abnormal_chromosome_stability1.86192188
23MP0002751_abnormal_autonomic_nervous1.80079622
24MP0003890_abnormal_embryonic-extraembry1.80066434
25MP0005647_abnormal_sex_gland1.77813476
26MP0000049_abnormal_middle_ear1.77570607
27MP0001664_abnormal_digestion1.75991493
28MP0003866_abnormal_defecation1.72089531
29MP0005389_reproductive_system_phenotype1.70850708
30MP0001666_abnormal_nutrient_absorption1.67874615
31MP0008877_abnormal_DNA_methylation1.64546242
32MP0003868_abnormal_feces_composition1.61895300
33MP0000653_abnormal_sex_gland1.55699300
34MP0003183_abnormal_peptide_metabolism1.54161817
35MP0003077_abnormal_cell_cycle1.51124572
36MP0005646_abnormal_pituitary_gland1.45792050
37MP0003698_abnormal_male_reproductive1.44423375
38MP0004233_abnormal_muscle_weight1.44399241
39MP0010307_abnormal_tumor_latency1.33124820
40MP0002161_abnormal_fertility/fecundity1.32538411
41MP0001730_embryonic_growth_arrest1.30304912
42MP0001119_abnormal_female_reproductive1.29996128
43MP0002277_abnormal_respiratory_mucosa1.28543731
44MP0001145_abnormal_male_reproductive1.23608190
45MP0003938_abnormal_ear_development1.22105522
46MP0002163_abnormal_gland_morphology1.13911635
47MP0003936_abnormal_reproductive_system1.11968656
48MP0000470_abnormal_stomach_morphology1.11260814
49MP0003111_abnormal_nucleus_morphology1.09760423
50MP0002127_abnormal_cardiovascular_syste1.04872171
51MP0006072_abnormal_retinal_apoptosis1.03354819
52MP0000372_irregular_coat_pigmentation1.02528915
53MP0000350_abnormal_cell_proliferation1.02129494
54MP0001881_abnormal_mammary_gland1.00705383
55MP0005076_abnormal_cell_differentiation0.99757445
56MP0001440_abnormal_grooming_behavior0.99467265
57MP0003121_genomic_imprinting0.98723513
58MP0001286_abnormal_eye_development0.96204657
59MP0005394_taste/olfaction_phenotype0.93993059
60MP0005499_abnormal_olfactory_system0.93993059
61MP0004957_abnormal_blastocyst_morpholog0.93145816
62MP0000631_abnormal_neuroendocrine_gland0.92823678
63MP0002396_abnormal_hematopoietic_system0.91474272
64MP0004043_abnormal_pH_regulation0.87904113
65MP0002102_abnormal_ear_morphology0.87385816
66MP0000428_abnormal_craniofacial_morphol0.83126242
67MP0002184_abnormal_innervation0.83083118
68MP0002090_abnormal_vision0.82615682
69MP0000462_abnormal_digestive_system0.81952900
70MP0004742_abnormal_vestibular_system0.81179318
71MP0000534_abnormal_ureter_morphology0.80090702
72MP0000778_abnormal_nervous_system0.79001217
73MP0000230_abnormal_systemic_arterial0.77466915
74MP0002229_neurodegeneration0.72379754
75MP0002249_abnormal_larynx_morphology0.72216257
76MP0004270_analgesia0.69110327
77MP0010030_abnormal_orbit_morphology0.69076910
78MP0003879_abnormal_hair_cell0.67391721
79MP0009384_cardiac_valve_regurgitation0.66925387
80MP0002085_abnormal_embryonic_tissue0.65522159
81MP0002272_abnormal_nervous_system0.63131715
82MP0001501_abnormal_sleep_pattern0.62261916
83MP0005623_abnormal_meninges_morphology0.59512059
84MP0003959_abnormal_lean_body0.59294425
85MP0001944_abnormal_pancreas_morphology0.57519935
86MP0008932_abnormal_embryonic_tissue0.56053896
87MP0000627_abnormal_mammary_gland0.55684339
88MP0002693_abnormal_pancreas_physiology0.55644994
89MP0005197_abnormal_uvea_morphology0.55483571
90MP0010368_abnormal_lymphatic_system0.54871600
91MP0004381_abnormal_hair_follicle0.53897508
92MP0003935_abnormal_craniofacial_develop0.52894134
93MP0001672_abnormal_embryogenesis/_devel0.51997856
94MP0005380_embryogenesis_phenotype0.51997856
95MP0001986_abnormal_taste_sensitivity0.51346944
96MP0009765_abnormal_xenobiotic_induced0.50288518
97MP0008789_abnormal_olfactory_epithelium0.50120304
98MP0005423_abnormal_somatic_nervous0.49640773
99MP0009703_decreased_birth_body0.49490291
100MP0005551_abnormal_eye_electrophysiolog0.49263508

Predicted human phenotypes

RankGene SetZ-score
1Premature ovarian failure (HP:0008209)8.28911510
2Median cleft lip (HP:0000161)5.27624612
3Microglossia (HP:0000171)4.80555480
4Short tibia (HP:0005736)4.77843825
5Aplasia/Hypoplasia of the tibia (HP:0005772)4.63181593
6Abnormal number of incisors (HP:0011064)4.35262286
7Facial cleft (HP:0002006)4.17125813
8Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.16324612
9Atonic seizures (HP:0010819)3.83955364
10Abnormal auditory evoked potentials (HP:0006958)3.75939804
11Abnormality of the nasal septum (HP:0000419)3.74006993
12Tetraparesis (HP:0002273)3.72477122
13Abdominal situs inversus (HP:0003363)3.70515453
14Abnormality of abdominal situs (HP:0011620)3.70515453
15Oligodactyly (hands) (HP:0001180)3.69778487
16Impulsivity (HP:0100710)3.62682915
17Male infertility (HP:0003251)3.61554479
18Tetany (HP:0001281)3.56521840
19Hyperphosphatemia (HP:0002905)3.50384620
20Metaphyseal dysplasia (HP:0100255)3.49747108
21Congenital sensorineural hearing impairment (HP:0008527)3.29880163
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.19540157
23Adrenal hypoplasia (HP:0000835)3.15908278
24Amelogenesis imperfecta (HP:0000705)3.12769945
25Short chin (HP:0000331)3.08105915
26Maternal diabetes (HP:0009800)3.03286161
27Degeneration of the lateral corticospinal tracts (HP:0002314)2.99402127
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.99402127
29Glossoptosis (HP:0000162)2.86605462
30Submucous cleft hard palate (HP:0000176)2.79640608
31Abnormality of calcium-phosphate metabolism (HP:0100530)2.79391619
32Autoimmune thrombocytopenia (HP:0001973)2.74325723
33Abnormality of the corticospinal tract (HP:0002492)2.72206159
34Microretrognathia (HP:0000308)2.71588909
35Neurofibrillary tangles (HP:0002185)2.70863022
36Loss of speech (HP:0002371)2.56455589
37Ectopic kidney (HP:0000086)2.49338919
38Abnormality of lateral ventricle (HP:0030047)2.48002270
39Myokymia (HP:0002411)2.47952788
40Type I diabetes mellitus (HP:0100651)2.44872405
41Oligodactyly (HP:0012165)2.44399063
42Abnormality of the labia minora (HP:0012880)2.43266356
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.42711230
44Reticulocytopenia (HP:0001896)2.42624146
45Multiple enchondromatosis (HP:0005701)2.41482275
46Rhinitis (HP:0012384)2.40478590
47Abnormality of the incisor (HP:0000676)2.39811397
48Abnormal pancreas size (HP:0012094)2.38953801
49Abnormal ciliary motility (HP:0012262)2.34780368
50Abnormality of dental color (HP:0011073)2.32087961
51Anhidrosis (HP:0000970)2.29643660
52Pancreatic fibrosis (HP:0100732)2.29165144
53Abnormality of chromosome stability (HP:0003220)2.28627579
54Anterior segment dysgenesis (HP:0007700)2.24566000
55Chromsome breakage (HP:0040012)2.24133135
56Abnormal respiratory motile cilium physiology (HP:0012261)2.10114179
57Exertional dyspnea (HP:0002875)2.06291504
58Sensory axonal neuropathy (HP:0003390)2.01224314
59Hypophosphatemic rickets (HP:0004912)2.00959713
60Partial agenesis of the corpus callosum (HP:0001338)1.96535702
61Hypoplasia of the radius (HP:0002984)1.94043744
62Autoimmune hemolytic anemia (HP:0001890)1.93978478
63Prostate neoplasm (HP:0100787)1.93577398
64Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92242055
65Dynein arm defect of respiratory motile cilia (HP:0012255)1.91511665
66Absent/shortened dynein arms (HP:0200106)1.91511665
67Short middle phalanx of the 5th finger (HP:0004220)1.90893899
68Aplasia/Hypoplasia of the earlobes (HP:0009906)1.90886355
69Diastasis recti (HP:0001540)1.90758873
70Hypoplasia of the iris (HP:0007676)1.87518846
71Absent thumb (HP:0009777)1.87153592
72Chronic bronchitis (HP:0004469)1.87034058
73Spinal muscular atrophy (HP:0007269)1.86388059
74Short thumb (HP:0009778)1.85314920
75Bony spicule pigmentary retinopathy (HP:0007737)1.85243067
76Increased hepatocellular lipid droplets (HP:0006565)1.84699434
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.83732835
78Optic nerve hypoplasia (HP:0000609)1.82749032
79Renal Fanconi syndrome (HP:0001994)1.82553435
80Genu varum (HP:0002970)1.82024454
81Aplasia/Hypoplasia of the sternum (HP:0006714)1.80853093
82Meckel diverticulum (HP:0002245)1.80327986
83Abnormality of the ileum (HP:0001549)1.78578599
84Osteomalacia (HP:0002749)1.76096067
85Bifid uvula (HP:0000193)1.76083807
86Apathy (HP:0000741)1.76021059
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74816370
88Abnormality of the frontal sinuses (HP:0002687)1.74515760
89Azoospermia (HP:0000027)1.74258807
90Abnormality of the preputium (HP:0100587)1.73296563
91Disproportionate short-trunk short stature (HP:0003521)1.72208794
92Proximal placement of thumb (HP:0009623)1.71472634
93Spastic diplegia (HP:0001264)1.70653306
94Decreased subcutaneous fat (HP:0001002)1.70503319
95Infertility (HP:0000789)1.68236897
96Cleft eyelid (HP:0000625)1.67860041
97Abnormality of purine metabolism (HP:0004352)1.67636095
98Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.67312065
99Selective tooth agenesis (HP:0001592)1.66963782
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65469550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK167.12147238
2CDK124.40516081
3TNIK3.79764430
4CDK193.55292787
5PLK43.40408991
6LATS22.82966696
7AURKA2.74393007
8TAOK32.73269817
9SRPK12.28634405
10TESK22.25047369
11VRK12.24420738
12ZAK2.17998781
13STK392.15773711
14ICK2.07678623
15TLK12.05737336
16CDC71.98135752
17TTK1.68659129
18NLK1.54771665
19TEC1.52497982
20ACVR1B1.49178611
21MAP2K31.47196349
22PBK1.43196617
23CHEK21.40801021
24WNK11.38203890
25AURKB1.35751919
26MAP3K31.24645328
27BMPR1B1.24429495
28BUB11.24119330
29LATS11.23477246
30PLK11.21342350
31PKN11.19070837
32STK241.16969801
33TRIM281.14468986
34EPHA41.10739742
35MELK1.09278427
36NUAK11.09244239
37ARAF1.02448875
38PIM20.97686743
39OXSR10.97365375
40VRK20.95122389
41SGK20.90489204
42STK38L0.85657956
43MARK20.85499026
44CHEK10.84928689
45BRAF0.84560122
46CDK70.82361696
47PLK20.81763454
48STK30.74341142
49PIK3CA0.72497400
50PIM10.69597244
51GRK70.65945523
52CSNK1E0.63019811
53CAMK40.60394261
54NEK60.57741445
55BRD40.57146477
56MOS0.55311954
57STK40.55211187
58RAF10.54860957
59MAPKAPK20.53738607
60CDK20.52289154
61PLK30.50317123
62MAPK130.49773350
63PAK10.48237224
64GRK50.47152269
65MTOR0.46658403
66WNK40.44799751
67DMPK0.43586615
68CAMK1D0.43572154
69CDK10.42707513
70ATM0.42364840
71SGK4940.42028509
72SGK2230.42028509
73PIK3CG0.42000609
74CSNK1D0.41769946
75CAMK10.40422570
76ILK0.39608971
77PRKD10.37177109
78AKT20.35997099
79CDK90.35845160
80SGK30.34528593
81ATR0.33770160
82MAP3K50.33495419
83PRKACA0.32599258
84RPS6KA50.31476696
85CSNK2A20.31177667
86CSNK2A10.30237960
87PRKACB0.28020607
88GSK3B0.26489267
89JAK30.25617935
90RPS6KA10.24220783
91STK100.24149725
92CDK50.23010691
93MAPK110.22449988
94MAPK10.22425524
95PRKCI0.22010506
96TBK10.21913884
97BRSK10.21424628
98ERBB40.21220305
99MAP3K90.21120227
100CSNK1G10.20948571

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005337.30357010
2Ribosome_Homo sapiens_hsa030103.57073476
3Dorso-ventral axis formation_Homo sapiens_hsa043203.31363403
4Basal transcription factors_Homo sapiens_hsa030223.27819947
5Mismatch repair_Homo sapiens_hsa034303.07478948
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01281782
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.79681915
8mRNA surveillance pathway_Homo sapiens_hsa030152.33601490
9Homologous recombination_Homo sapiens_hsa034402.29470338
10Bile secretion_Homo sapiens_hsa049762.29274544
11Sulfur metabolism_Homo sapiens_hsa009202.20294576
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.14711897
13RNA transport_Homo sapiens_hsa030132.04204238
14Non-homologous end-joining_Homo sapiens_hsa034501.91813907
15RNA polymerase_Homo sapiens_hsa030201.88999196
16Fanconi anemia pathway_Homo sapiens_hsa034601.87379326
17Oocyte meiosis_Homo sapiens_hsa041141.86313802
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.76204120
19Fatty acid biosynthesis_Homo sapiens_hsa000611.72618045
20Vitamin B6 metabolism_Homo sapiens_hsa007501.61531954
21Cell cycle_Homo sapiens_hsa041101.43157321
22Ovarian steroidogenesis_Homo sapiens_hsa049131.39075739
23Spliceosome_Homo sapiens_hsa030401.38006831
24DNA replication_Homo sapiens_hsa030301.37572242
25RNA degradation_Homo sapiens_hsa030181.30235510
26Olfactory transduction_Homo sapiens_hsa047401.29489643
27Retinol metabolism_Homo sapiens_hsa008301.27310826
28Systemic lupus erythematosus_Homo sapiens_hsa053221.23549788
29Tryptophan metabolism_Homo sapiens_hsa003801.22194803
30Phototransduction_Homo sapiens_hsa047441.18571524
31Linoleic acid metabolism_Homo sapiens_hsa005911.09719704
32Alcoholism_Homo sapiens_hsa050341.08080102
33p53 signaling pathway_Homo sapiens_hsa041151.07030237
34Insulin secretion_Homo sapiens_hsa049111.02799057
35Pyrimidine metabolism_Homo sapiens_hsa002400.89255730
36Serotonergic synapse_Homo sapiens_hsa047260.85663405
37Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84263636
38Hedgehog signaling pathway_Homo sapiens_hsa043400.82192480
39Folate biosynthesis_Homo sapiens_hsa007900.81069545
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80127035
41Purine metabolism_Homo sapiens_hsa002300.77689378
42Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74860854
43Chemical carcinogenesis_Homo sapiens_hsa052040.73381542
44Herpes simplex infection_Homo sapiens_hsa051680.73337717
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72125961
46Taste transduction_Homo sapiens_hsa047420.69002276
47Lysine degradation_Homo sapiens_hsa003100.67159191
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65055855
49Colorectal cancer_Homo sapiens_hsa052100.64526274
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61105553
51Circadian rhythm_Homo sapiens_hsa047100.60907896
52GABAergic synapse_Homo sapiens_hsa047270.60562242
53Regulation of autophagy_Homo sapiens_hsa041400.59458257
54Cholinergic synapse_Homo sapiens_hsa047250.58484494
55Tight junction_Homo sapiens_hsa045300.58021383
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56657013
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.54775224
58Viral carcinogenesis_Homo sapiens_hsa052030.52625431
59cAMP signaling pathway_Homo sapiens_hsa040240.51407378
60Nicotine addiction_Homo sapiens_hsa050330.49806137
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48875703
62Cocaine addiction_Homo sapiens_hsa050300.48770806
63Arachidonic acid metabolism_Homo sapiens_hsa005900.48466888
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48433377
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47572737
66Wnt signaling pathway_Homo sapiens_hsa043100.46655627
67Nucleotide excision repair_Homo sapiens_hsa034200.45905154
68Huntingtons disease_Homo sapiens_hsa050160.45720776
69Hippo signaling pathway_Homo sapiens_hsa043900.45689902
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45213137
71Gap junction_Homo sapiens_hsa045400.44961064
72Morphine addiction_Homo sapiens_hsa050320.42871229
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41305047
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36412763
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36243716
76TGF-beta signaling pathway_Homo sapiens_hsa043500.35308429
77Dopaminergic synapse_Homo sapiens_hsa047280.35048650
78Legionellosis_Homo sapiens_hsa051340.32651691
79MicroRNAs in cancer_Homo sapiens_hsa052060.30772981
80Calcium signaling pathway_Homo sapiens_hsa040200.30435934
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.28938142
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28545755
83Starch and sucrose metabolism_Homo sapiens_hsa005000.27439323
84Apoptosis_Homo sapiens_hsa042100.26695390
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25713950
86Adherens junction_Homo sapiens_hsa045200.24383106
87Basal cell carcinoma_Homo sapiens_hsa052170.23381902
88Protein digestion and absorption_Homo sapiens_hsa049740.22365522
89Amphetamine addiction_Homo sapiens_hsa050310.20673976
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19935396
91Pancreatic secretion_Homo sapiens_hsa049720.19802725
92Circadian entrainment_Homo sapiens_hsa047130.18987490
93Base excision repair_Homo sapiens_hsa034100.18855727
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.17026179
95MAPK signaling pathway_Homo sapiens_hsa040100.13450057
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13179497
97Estrogen signaling pathway_Homo sapiens_hsa049150.12968985
98Synaptic vesicle cycle_Homo sapiens_hsa047210.12891053
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12783225
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.12658104

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