ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oocyte development (GO:0048599)	8.25339860
2	histone lysine demethylation (GO:0070076)	7.29455066
3	histone demethylation (GO:0016577)	6.90421924
4	multicellular organism reproduction (GO:0032504)	6.73301110
5	regulation of exit from mitosis (GO:0007096)	6.65652740
6	synaptonemal complex organization (GO:0070193)	6.48209518
7	regulation of RIG-I signaling pathway (GO:0039535)	6.30589532
8	regulation of acrosome reaction (GO:0060046)	6.23623674
9	protein dealkylation (GO:0008214)	6.23259605
10	protein demethylation (GO:0006482)	6.23259605
11	synaptonemal complex assembly (GO:0007130)	6.22124057
12	positive regulation of meiosis (GO:0045836)	5.98762628
13	positive regulation of meiotic cell cycle (GO:0051446)	5.75923929
14	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.61887464
15	gonadal mesoderm development (GO:0007506)	5.59152063
16	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	5.51993184
17	positive regulation of catecholamine secretion (GO:0033605)	5.51614465
18	male meiosis I (GO:0007141)	5.43581795
19	N-terminal protein amino acid acetylation (GO:0006474)	5.40747638
20	negative regulation of Ras GTPase activity (GO:0034261)	5.30617462
21	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	5.25335146
22	regulation of female receptivity (GO:0045924)	4.99642528
23	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.94250199
24	single fertilization (GO:0007338)	4.69966766
25	male meiosis (GO:0007140)	4.55121132
26	acrosome reaction (GO:0007340)	4.47981703
27	reproduction (GO:0000003)	4.46779650
28	meiosis I (GO:0007127)	4.44435545
29	regulation of uterine smooth muscle contraction (GO:0070472)	4.35897250
30	binding of sperm to zona pellucida (GO:0007339)	4.30681120
31	female mating behavior (GO:0060180)	4.28249240
32	protein K48-linked deubiquitination (GO:0071108)	4.10901269
33	aggressive behavior (GO:0002118)	3.98246018
34	protein kinase C signaling (GO:0070528)	3.97540062
35	chromosome organization involved in meiosis (GO:0070192)	3.92405036
36	response to UV-C (GO:0010225)	3.88508451
37	drinking behavior (GO:0042756)	3.82992935
38	protein K6-linked ubiquitination (GO:0085020)	3.73671552
39	positive regulation of digestive system process (GO:0060456)	3.66566742
40	positive regulation of histone H3-K4 methylation (GO:0051571)	3.63622190
41	regulation of meiosis (GO:0040020)	3.62697567
42	fertilization (GO:0009566)	3.60959354
43	regulation of penile erection (GO:0060405)	3.59086165
44	negative regulation of reproductive process (GO:2000242)	3.57022349
45	regulation of helicase activity (GO:0051095)	3.53507785
46	positive regulation of prostaglandin secretion (GO:0032308)	3.48602637
47	maturation of SSU-rRNA (GO:0030490)	3.43866491
48	hyperosmotic salinity response (GO:0042538)	3.41696632
49	regulation of histone H3-K9 methylation (GO:0051570)	3.40834316
50	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.40525298
51	regulation of female gonad development (GO:2000194)	3.40373117
52	negative regulation of digestive system process (GO:0060457)	3.39180410
53	intestinal epithelial cell development (GO:0060576)	3.38454798
54	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.38201262
55	positive regulation of humoral immune response (GO:0002922)	3.35321612
56	centriole replication (GO:0007099)	3.32305263
57	regulation of mRNA splicing, via spliceosome (GO:0048024)	3.31502792
58	sleep (GO:0030431)	3.31330623
59	sperm-egg recognition (GO:0035036)	3.29090169
60	meiotic cell cycle process (GO:1903046)	3.25270497
61	demethylation (GO:0070988)	3.23726285
62	citrulline biosynthetic process (GO:0019240)	3.16983350
63	piRNA metabolic process (GO:0034587)	3.16261853
64	protein K63-linked deubiquitination (GO:0070536)	3.11503707
65	regulation of ruffle assembly (GO:1900027)	3.10859557
66	meiotic cell cycle (GO:0051321)	3.10213099
67	calcium ion-dependent exocytosis (GO:0017156)	3.05746897
68	RNA localization (GO:0006403)	3.03014161
69	poly(A)+ mRNA export from nucleus (GO:0016973)	3.01076270
70	regulation of defense response to virus by host (GO:0050691)	3.00178781
71	positive regulation of reproductive process (GO:2000243)	2.97840488
72	regulation of meiotic cell cycle (GO:0051445)	2.97362414
73	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.96347503
74	transcription from mitochondrial promoter (GO:0006390)	2.88730137
75	negative regulation of histone modification (GO:0031057)	2.88359778
76	regulation of mRNA processing (GO:0050684)	2.87916223
77	striated muscle atrophy (GO:0014891)	2.86594404
78	phosphate ion homeostasis (GO:0055062)	2.86201400
79	trivalent inorganic anion homeostasis (GO:0072506)	2.86201400
80	regulation of prostaglandin secretion (GO:0032306)	2.84182250
81	epithelial cilium movement (GO:0003351)	2.83933515
82	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.82815409
83	maternal behavior (GO:0042711)	2.82706245
84	mitotic metaphase plate congression (GO:0007080)	2.82612930
85	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.76215363
86	spermatid development (GO:0007286)	2.75798608
87	regulation of DNA endoreduplication (GO:0032875)	2.75486401
88	N-terminal protein amino acid modification (GO:0031365)	2.74753131
89	response to prostaglandin (GO:0034694)	2.74749781
90	regulation of DNA methylation (GO:0044030)	2.74285189
91	cilium movement (GO:0003341)	2.74132223
92	mitochondrial RNA metabolic process (GO:0000959)	2.72369375
93	exocrine pancreas development (GO:0031017)	2.70299362
94	DNA replication-dependent nucleosome assembly (GO:0006335)	2.65596449
95	DNA replication-dependent nucleosome organization (GO:0034723)	2.65596449
96	cell-cell recognition (GO:0009988)	2.64804355
97	meiotic nuclear division (GO:0007126)	2.64329856
98	histone H3-K9 demethylation (GO:0033169)	18.2115748
99	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	17.5504077
100	regulation of retinoic acid receptor signaling pathway (GO:0048385)	14.6683282

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	9.14750739
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.68422387
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.68577478
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.73817612
5	VDR_22108803_ChIP-Seq_LS180_Human	3.43154140
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.02947802
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.85640749
8	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.81360511
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.67293719
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.48805771
11	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.46205240
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30914483
13	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.29806860
14	E2F7_22180533_ChIP-Seq_HELA_Human	2.19099407
15	IRF1_19129219_ChIP-ChIP_H3396_Human	2.17826945
16	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.17706454
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.12428080
18	AUTS2_25519132_ChIP-Seq_293T-REX_Human	2.10872970
19	AR_21909140_ChIP-Seq_LNCAP_Human	2.09519498
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.07464891
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94125382
22	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.87200042
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.81363658
24	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.78686752
25	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.78686752
26	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.78686752
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.76616524
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.76436462
29	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.76246942
30	TCF4_23295773_ChIP-Seq_U87_Human	1.67764153
31	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.64169092
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63961210
33	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.63353185
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.63048910
35	CBP_21632823_ChIP-Seq_H3396_Human	1.62209390
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.60047859
37	RXR_22108803_ChIP-Seq_LS180_Human	1.54711513
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.51358829
39	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.50207176
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.46222269
41	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.44753940
42	STAT3_23295773_ChIP-Seq_U87_Human	1.42620333
43	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.41042328
44	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.40705838
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.38928273
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37691924
47	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.37111692
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35515402
49	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.35444462
50	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.34873500
51	NCOR_22424771_ChIP-Seq_293T_Human	1.34204620
52	P300_19829295_ChIP-Seq_ESCs_Human	1.34052236
53	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.32363859
54	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.32038187
55	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.31011752
56	GF1_26923725_Chip-Seq_HPCs_Mouse	1.29821088
57	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.29603555
58	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.29117011
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.28193422
60	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.27994047
61	GATA3_26560356_Chip-Seq_TH1_Human	1.27608443
62	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.22060027
63	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.21361969
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.21187308
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19838643
66	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.19786465
67	ZNF274_21170338_ChIP-Seq_K562_Hela	1.19095530
68	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.16877237
69	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.15732204
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.15675185
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13450366
72	TTF2_22483619_ChIP-Seq_HELA_Human	1.12929108
73	BCAT_22108803_ChIP-Seq_LS180_Human	1.10805806
74	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.10018821
75	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.09954775
76	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.05677170
77	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.05568512
78	RAC3_21632823_ChIP-Seq_H3396_Human	1.04983377
79	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.02219462
80	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.00085075
81	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.99248616
82	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.98430542
83	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.97981857
84	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.97883139
85	* AR_25329375_ChIP-Seq_VCAP_Human	0.97878819
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.94125344
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93825761
88	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.93750943
89	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.93175992
90	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.93155173
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.91757749
92	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.90966512
93	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.90704976
94	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.87598879
95	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.87591293
96	AR_21572438_ChIP-Seq_LNCaP_Human	0.87327757
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.87294415
98	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.86426413
99	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.85885158
100	TP53_22573176_ChIP-Seq_HFKS_Human	0.85407752

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	6.29027682
2	MP0003283_abnormal_digestive_organ	4.92481419
3	MP0009379_abnormal_foot_pigmentation	4.18881475
4	MP0003950_abnormal_plasma_membrane	3.94943662
5	MP0003693_abnormal_embryo_hatching	3.75612047
6	MP0000678_abnormal_parathyroid_gland	3.73885212
7	MP0002160_abnormal_reproductive_system	3.37345431
8	MP0005410_abnormal_fertilization	3.11866422
9	MP0003136_yellow_coat_color	2.94149944
10	MP0009840_abnormal_foam_cell	2.89085124
11	MP0001929_abnormal_gametogenesis	2.54049453
12	MP0006276_abnormal_autonomic_nervous	2.52121719
13	MP0000427_abnormal_hair_cycle	2.49222494
14	MP0008058_abnormal_DNA_repair	2.47881540
15	MP0005360_urolithiasis	2.32770900
16	MP0001502_abnormal_circadian_rhythm	2.29355619
17	MP0002210_abnormal_sex_determination	2.21365160
18	MP0003699_abnormal_female_reproductive	2.02546363
19	MP0005220_abnormal_exocrine_pancreas	1.98259238
20	MP0003119_abnormal_digestive_system	1.93112349
21	MP0003718_maternal_effect	1.88354867
22	MP0010094_abnormal_chromosome_stability	1.86192188
23	MP0002751_abnormal_autonomic_nervous	1.80079622
24	MP0003890_abnormal_embryonic-extraembry	1.80066434
25	MP0005647_abnormal_sex_gland	1.77813476
26	MP0000049_abnormal_middle_ear	1.77570607
27	MP0001664_abnormal_digestion	1.75991493
28	MP0003866_abnormal_defecation	1.72089531
29	MP0005389_reproductive_system_phenotype	1.70850708
30	MP0001666_abnormal_nutrient_absorption	1.67874615
31	MP0008877_abnormal_DNA_methylation	1.64546242
32	MP0003868_abnormal_feces_composition	1.61895300
33	MP0000653_abnormal_sex_gland	1.55699300
34	MP0003183_abnormal_peptide_metabolism	1.54161817
35	MP0003077_abnormal_cell_cycle	1.51124572
36	MP0005646_abnormal_pituitary_gland	1.45792050
37	MP0003698_abnormal_male_reproductive	1.44423375
38	MP0004233_abnormal_muscle_weight	1.44399241
39	MP0010307_abnormal_tumor_latency	1.33124820
40	MP0002161_abnormal_fertility/fecundity	1.32538411
41	MP0001730_embryonic_growth_arrest	1.30304912
42	MP0001119_abnormal_female_reproductive	1.29996128
43	MP0002277_abnormal_respiratory_mucosa	1.28543731
44	MP0001145_abnormal_male_reproductive	1.23608190
45	MP0003938_abnormal_ear_development	1.22105522
46	MP0002163_abnormal_gland_morphology	1.13911635
47	MP0003936_abnormal_reproductive_system	1.11968656
48	MP0000470_abnormal_stomach_morphology	1.11260814
49	MP0003111_abnormal_nucleus_morphology	1.09760423
50	MP0002127_abnormal_cardiovascular_syste	1.04872171
51	MP0006072_abnormal_retinal_apoptosis	1.03354819
52	MP0000372_irregular_coat_pigmentation	1.02528915
53	MP0000350_abnormal_cell_proliferation	1.02129494
54	MP0001881_abnormal_mammary_gland	1.00705383
55	MP0005076_abnormal_cell_differentiation	0.99757445
56	MP0001440_abnormal_grooming_behavior	0.99467265
57	MP0003121_genomic_imprinting	0.98723513
58	MP0001286_abnormal_eye_development	0.96204657
59	MP0005394_taste/olfaction_phenotype	0.93993059
60	MP0005499_abnormal_olfactory_system	0.93993059
61	MP0004957_abnormal_blastocyst_morpholog	0.93145816
62	MP0000631_abnormal_neuroendocrine_gland	0.92823678
63	MP0002396_abnormal_hematopoietic_system	0.91474272
64	MP0004043_abnormal_pH_regulation	0.87904113
65	MP0002102_abnormal_ear_morphology	0.87385816
66	MP0000428_abnormal_craniofacial_morphol	0.83126242
67	MP0002184_abnormal_innervation	0.83083118
68	MP0002090_abnormal_vision	0.82615682
69	MP0000462_abnormal_digestive_system	0.81952900
70	MP0004742_abnormal_vestibular_system	0.81179318
71	MP0000534_abnormal_ureter_morphology	0.80090702
72	MP0000778_abnormal_nervous_system	0.79001217
73	MP0000230_abnormal_systemic_arterial	0.77466915
74	MP0002229_neurodegeneration	0.72379754
75	MP0002249_abnormal_larynx_morphology	0.72216257
76	MP0004270_analgesia	0.69110327
77	MP0010030_abnormal_orbit_morphology	0.69076910
78	MP0003879_abnormal_hair_cell	0.67391721
79	MP0009384_cardiac_valve_regurgitation	0.66925387
80	MP0002085_abnormal_embryonic_tissue	0.65522159
81	MP0002272_abnormal_nervous_system	0.63131715
82	MP0001501_abnormal_sleep_pattern	0.62261916
83	MP0005623_abnormal_meninges_morphology	0.59512059
84	MP0003959_abnormal_lean_body	0.59294425
85	MP0001944_abnormal_pancreas_morphology	0.57519935
86	MP0008932_abnormal_embryonic_tissue	0.56053896
87	MP0000627_abnormal_mammary_gland	0.55684339
88	MP0002693_abnormal_pancreas_physiology	0.55644994
89	MP0005197_abnormal_uvea_morphology	0.55483571
90	MP0010368_abnormal_lymphatic_system	0.54871600
91	MP0004381_abnormal_hair_follicle	0.53897508
92	MP0003935_abnormal_craniofacial_develop	0.52894134
93	MP0001672_abnormal_embryogenesis/_devel	0.51997856
94	MP0005380_embryogenesis_phenotype	0.51997856
95	MP0001986_abnormal_taste_sensitivity	0.51346944
96	MP0009765_abnormal_xenobiotic_induced	0.50288518
97	MP0008789_abnormal_olfactory_epithelium	0.50120304
98	MP0005423_abnormal_somatic_nervous	0.49640773
99	MP0009703_decreased_birth_body	0.49490291
100	MP0005551_abnormal_eye_electrophysiolog	0.49263508

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	8.28911510
2	Median cleft lip (HP:0000161)	5.27624612
3	Microglossia (HP:0000171)	4.80555480
4	Short tibia (HP:0005736)	4.77843825
5	Aplasia/Hypoplasia of the tibia (HP:0005772)	4.63181593
6	Abnormal number of incisors (HP:0011064)	4.35262286
7	Facial cleft (HP:0002006)	4.17125813
8	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.16324612
9	Atonic seizures (HP:0010819)	3.83955364
10	Abnormal auditory evoked potentials (HP:0006958)	3.75939804
11	Abnormality of the nasal septum (HP:0000419)	3.74006993
12	Tetraparesis (HP:0002273)	3.72477122
13	Abdominal situs inversus (HP:0003363)	3.70515453
14	Abnormality of abdominal situs (HP:0011620)	3.70515453
15	Oligodactyly (hands) (HP:0001180)	3.69778487
16	Impulsivity (HP:0100710)	3.62682915
17	Male infertility (HP:0003251)	3.61554479
18	Tetany (HP:0001281)	3.56521840
19	Hyperphosphatemia (HP:0002905)	3.50384620
20	Metaphyseal dysplasia (HP:0100255)	3.49747108
21	Congenital sensorineural hearing impairment (HP:0008527)	3.29880163
22	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.19540157
23	Adrenal hypoplasia (HP:0000835)	3.15908278
24	Amelogenesis imperfecta (HP:0000705)	3.12769945
25	Short chin (HP:0000331)	3.08105915
26	Maternal diabetes (HP:0009800)	3.03286161
27	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.99402127
28	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.99402127
29	Glossoptosis (HP:0000162)	2.86605462
30	Submucous cleft hard palate (HP:0000176)	2.79640608
31	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.79391619
32	Autoimmune thrombocytopenia (HP:0001973)	2.74325723
33	Abnormality of the corticospinal tract (HP:0002492)	2.72206159
34	Microretrognathia (HP:0000308)	2.71588909
35	Neurofibrillary tangles (HP:0002185)	2.70863022
36	Loss of speech (HP:0002371)	2.56455589
37	Ectopic kidney (HP:0000086)	2.49338919
38	Abnormality of lateral ventricle (HP:0030047)	2.48002270
39	Myokymia (HP:0002411)	2.47952788
40	Type I diabetes mellitus (HP:0100651)	2.44872405
41	Oligodactyly (HP:0012165)	2.44399063
42	Abnormality of the labia minora (HP:0012880)	2.43266356
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.42711230
44	Reticulocytopenia (HP:0001896)	2.42624146
45	Multiple enchondromatosis (HP:0005701)	2.41482275
46	Rhinitis (HP:0012384)	2.40478590
47	Abnormality of the incisor (HP:0000676)	2.39811397
48	Abnormal pancreas size (HP:0012094)	2.38953801
49	Abnormal ciliary motility (HP:0012262)	2.34780368
50	Abnormality of dental color (HP:0011073)	2.32087961
51	Anhidrosis (HP:0000970)	2.29643660
52	Pancreatic fibrosis (HP:0100732)	2.29165144
53	Abnormality of chromosome stability (HP:0003220)	2.28627579
54	Anterior segment dysgenesis (HP:0007700)	2.24566000
55	Chromsome breakage (HP:0040012)	2.24133135
56	Abnormal respiratory motile cilium physiology (HP:0012261)	2.10114179
57	Exertional dyspnea (HP:0002875)	2.06291504
58	Sensory axonal neuropathy (HP:0003390)	2.01224314
59	Hypophosphatemic rickets (HP:0004912)	2.00959713
60	Partial agenesis of the corpus callosum (HP:0001338)	1.96535702
61	Hypoplasia of the radius (HP:0002984)	1.94043744
62	Autoimmune hemolytic anemia (HP:0001890)	1.93978478
63	Prostate neoplasm (HP:0100787)	1.93577398
64	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.92242055
65	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.91511665
66	Absent/shortened dynein arms (HP:0200106)	1.91511665
67	Short middle phalanx of the 5th finger (HP:0004220)	1.90893899
68	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.90886355
69	Diastasis recti (HP:0001540)	1.90758873
70	Hypoplasia of the iris (HP:0007676)	1.87518846
71	Absent thumb (HP:0009777)	1.87153592
72	Chronic bronchitis (HP:0004469)	1.87034058
73	Spinal muscular atrophy (HP:0007269)	1.86388059
74	Short thumb (HP:0009778)	1.85314920
75	Bony spicule pigmentary retinopathy (HP:0007737)	1.85243067
76	Increased hepatocellular lipid droplets (HP:0006565)	1.84699434
77	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.83732835
78	Optic nerve hypoplasia (HP:0000609)	1.82749032
79	Renal Fanconi syndrome (HP:0001994)	1.82553435
80	Genu varum (HP:0002970)	1.82024454
81	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.80853093
82	Meckel diverticulum (HP:0002245)	1.80327986
83	Abnormality of the ileum (HP:0001549)	1.78578599
84	Osteomalacia (HP:0002749)	1.76096067
85	Bifid uvula (HP:0000193)	1.76083807
86	Apathy (HP:0000741)	1.76021059
87	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74816370
88	Abnormality of the frontal sinuses (HP:0002687)	1.74515760
89	Azoospermia (HP:0000027)	1.74258807
90	Abnormality of the preputium (HP:0100587)	1.73296563
91	Disproportionate short-trunk short stature (HP:0003521)	1.72208794
92	Proximal placement of thumb (HP:0009623)	1.71472634
93	Spastic diplegia (HP:0001264)	1.70653306
94	Decreased subcutaneous fat (HP:0001002)	1.70503319
95	Infertility (HP:0000789)	1.68236897
96	Cleft eyelid (HP:0000625)	1.67860041
97	Abnormality of purine metabolism (HP:0004352)	1.67636095
98	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.67312065
99	Selective tooth agenesis (HP:0001592)	1.66963782
100	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.65469550

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	7.12147238
2	CDK12	4.40516081
3	TNIK	3.79764430
4	CDK19	3.55292787
5	PLK4	3.40408991
6	LATS2	2.82966696
7	AURKA	2.74393007
8	TAOK3	2.73269817
9	SRPK1	2.28634405
10	TESK2	2.25047369
11	VRK1	2.24420738
12	ZAK	2.17998781
13	STK39	2.15773711
14	ICK	2.07678623
15	TLK1	2.05737336
16	CDC7	1.98135752
17	TTK	1.68659129
18	NLK	1.54771665
19	TEC	1.52497982
20	ACVR1B	1.49178611
21	MAP2K3	1.47196349
22	PBK	1.43196617
23	CHEK2	1.40801021
24	WNK1	1.38203890
25	AURKB	1.35751919
26	MAP3K3	1.24645328
27	BMPR1B	1.24429495
28	BUB1	1.24119330
29	LATS1	1.23477246
30	PLK1	1.21342350
31	PKN1	1.19070837
32	STK24	1.16969801
33	TRIM28	1.14468986
34	EPHA4	1.10739742
35	MELK	1.09278427
36	NUAK1	1.09244239
37	ARAF	1.02448875
38	PIM2	0.97686743
39	OXSR1	0.97365375
40	VRK2	0.95122389
41	SGK2	0.90489204
42	STK38L	0.85657956
43	MARK2	0.85499026
44	CHEK1	0.84928689
45	BRAF	0.84560122
46	CDK7	0.82361696
47	PLK2	0.81763454
48	STK3	0.74341142
49	PIK3CA	0.72497400
50	PIM1	0.69597244
51	GRK7	0.65945523
52	CSNK1E	0.63019811
53	CAMK4	0.60394261
54	NEK6	0.57741445
55	BRD4	0.57146477
56	MOS	0.55311954
57	STK4	0.55211187
58	RAF1	0.54860957
59	MAPKAPK2	0.53738607
60	CDK2	0.52289154
61	PLK3	0.50317123
62	MAPK13	0.49773350
63	PAK1	0.48237224
64	GRK5	0.47152269
65	MTOR	0.46658403
66	WNK4	0.44799751
67	DMPK	0.43586615
68	CAMK1D	0.43572154
69	CDK1	0.42707513
70	ATM	0.42364840
71	SGK494	0.42028509
72	SGK223	0.42028509
73	PIK3CG	0.42000609
74	CSNK1D	0.41769946
75	CAMK1	0.40422570
76	ILK	0.39608971
77	PRKD1	0.37177109
78	AKT2	0.35997099
79	CDK9	0.35845160
80	SGK3	0.34528593
81	ATR	0.33770160
82	MAP3K5	0.33495419
83	PRKACA	0.32599258
84	RPS6KA5	0.31476696
85	CSNK2A2	0.31177667
86	CSNK2A1	0.30237960
87	PRKACB	0.28020607
88	GSK3B	0.26489267
89	JAK3	0.25617935
90	RPS6KA1	0.24220783
91	STK10	0.24149725
92	CDK5	0.23010691
93	MAPK11	0.22449988
94	MAPK1	0.22425524
95	PRKCI	0.22010506
96	TBK1	0.21913884
97	BRSK1	0.21424628
98	ERBB4	0.21220305
99	MAP3K9	0.21120227
100	CSNK1G1	0.20948571

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	7.30357010
2	Ribosome_Homo sapiens_hsa03010	3.57073476
3	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.31363403
4	Basal transcription factors_Homo sapiens_hsa03022	3.27819947
5	Mismatch repair_Homo sapiens_hsa03430	3.07478948
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.01281782
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.79681915
8	mRNA surveillance pathway_Homo sapiens_hsa03015	2.33601490
9	Homologous recombination_Homo sapiens_hsa03440	2.29470338
10	Bile secretion_Homo sapiens_hsa04976	2.29274544
11	Sulfur metabolism_Homo sapiens_hsa00920	2.20294576
12	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.14711897
13	RNA transport_Homo sapiens_hsa03013	2.04204238
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.91813907
15	RNA polymerase_Homo sapiens_hsa03020	1.88999196
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.87379326
17	Oocyte meiosis_Homo sapiens_hsa04114	1.86313802
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.76204120
19	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.72618045
20	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.61531954
21	Cell cycle_Homo sapiens_hsa04110	1.43157321
22	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.39075739
23	Spliceosome_Homo sapiens_hsa03040	1.38006831
24	DNA replication_Homo sapiens_hsa03030	1.37572242
25	RNA degradation_Homo sapiens_hsa03018	1.30235510
26	Olfactory transduction_Homo sapiens_hsa04740	1.29489643
27	Retinol metabolism_Homo sapiens_hsa00830	1.27310826
28	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.23549788
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.22194803
30	Phototransduction_Homo sapiens_hsa04744	1.18571524
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.09719704
32	Alcoholism_Homo sapiens_hsa05034	1.08080102
33	p53 signaling pathway_Homo sapiens_hsa04115	1.07030237
34	Insulin secretion_Homo sapiens_hsa04911	1.02799057
35	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89255730
36	Serotonergic synapse_Homo sapiens_hsa04726	0.85663405
37	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.84263636
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.82192480
39	Folate biosynthesis_Homo sapiens_hsa00790	0.81069545
40	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.80127035
41	Purine metabolism_Homo sapiens_hsa00230	0.77689378
42	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.74860854
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73381542
44	Herpes simplex infection_Homo sapiens_hsa05168	0.73337717
45	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.72125961
46	Taste transduction_Homo sapiens_hsa04742	0.69002276
47	Lysine degradation_Homo sapiens_hsa00310	0.67159191
48	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.65055855
49	Colorectal cancer_Homo sapiens_hsa05210	0.64526274
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61105553
51	Circadian rhythm_Homo sapiens_hsa04710	0.60907896
52	GABAergic synapse_Homo sapiens_hsa04727	0.60562242
53	Regulation of autophagy_Homo sapiens_hsa04140	0.59458257
54	Cholinergic synapse_Homo sapiens_hsa04725	0.58484494
55	Tight junction_Homo sapiens_hsa04530	0.58021383
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56657013
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54775224
58	Viral carcinogenesis_Homo sapiens_hsa05203	0.52625431
59	cAMP signaling pathway_Homo sapiens_hsa04024	0.51407378
60	Nicotine addiction_Homo sapiens_hsa05033	0.49806137
61	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.48875703
62	Cocaine addiction_Homo sapiens_hsa05030	0.48770806
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48466888
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48433377
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.47572737
66	Wnt signaling pathway_Homo sapiens_hsa04310	0.46655627
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.45905154
68	Huntingtons disease_Homo sapiens_hsa05016	0.45720776
69	Hippo signaling pathway_Homo sapiens_hsa04390	0.45689902
70	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.45213137
71	Gap junction_Homo sapiens_hsa04540	0.44961064
72	Morphine addiction_Homo sapiens_hsa05032	0.42871229
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41305047
74	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.36412763
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.36243716
76	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35308429
77	Dopaminergic synapse_Homo sapiens_hsa04728	0.35048650
78	Legionellosis_Homo sapiens_hsa05134	0.32651691
79	MicroRNAs in cancer_Homo sapiens_hsa05206	0.30772981
80	Calcium signaling pathway_Homo sapiens_hsa04020	0.30435934
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28938142
82	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.28545755
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.27439323
84	Apoptosis_Homo sapiens_hsa04210	0.26695390
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.25713950
86	Adherens junction_Homo sapiens_hsa04520	0.24383106
87	Basal cell carcinoma_Homo sapiens_hsa05217	0.23381902
88	Protein digestion and absorption_Homo sapiens_hsa04974	0.22365522
89	Amphetamine addiction_Homo sapiens_hsa05031	0.20673976
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.19935396
91	Pancreatic secretion_Homo sapiens_hsa04972	0.19802725
92	Circadian entrainment_Homo sapiens_hsa04713	0.18987490
93	Base excision repair_Homo sapiens_hsa03410	0.18855727
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.17026179
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.13450057
96	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.13179497
97	Estrogen signaling pathway_Homo sapiens_hsa04915	0.12968985
98	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.12891053
99	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.12783225
100	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.12658104

TRIM43

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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