TRIM43B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oocyte development (GO:0048599)7.81314616
2multicellular organism reproduction (GO:0032504)7.16266578
3purine nucleobase biosynthetic process (GO:0009113)6.86802305
4regulation of acrosome reaction (GO:0060046)6.86311139
5mitotic metaphase plate congression (GO:0007080)6.63071110
6histone lysine demethylation (GO:0070076)6.35103446
7vitamin transmembrane transport (GO:0035461)6.11907543
8positive regulation of uterine smooth muscle contraction (GO:0070474)6.04482597
9histone demethylation (GO:0016577)6.01017043
10nucleobase biosynthetic process (GO:0046112)5.89488480
11ribosome assembly (GO:0042255)5.86611723
12regulation of spindle organization (GO:0090224)5.69261717
13synaptonemal complex organization (GO:0070193)5.63885518
14positive regulation of catecholamine secretion (GO:0033605)5.47110613
15protein demethylation (GO:0006482)5.42374470
16protein dealkylation (GO:0008214)5.42374470
17synaptonemal complex assembly (GO:0007130)5.41877580
18regulation of RIG-I signaling pathway (GO:0039535)5.38285467
19regulation of cytokine production involved in inflammatory response (GO:1900015)5.36873916
20positive regulation of meiosis (GO:0045836)5.28723178
21ribosome biogenesis (GO:0042254)5.28651382
22termination of RNA polymerase III transcription (GO:0006386)5.24139101
23transcription elongation from RNA polymerase III promoter (GO:0006385)5.24139101
24DNA replication checkpoint (GO:0000076)5.21340338
25regulation of female receptivity (GO:0045924)5.21109324
26positive regulation of meiotic cell cycle (GO:0051446)5.14717773
27N-terminal protein amino acid acetylation (GO:0006474)5.14530932
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.11575154
29rRNA modification (GO:0000154)4.99596604
30metaphase plate congression (GO:0051310)4.99427309
31gonadal mesoderm development (GO:0007506)4.94992034
32regulation of alternative mRNA splicing, via spliceosome (GO:0000381)4.88546022
33termination of RNA polymerase I transcription (GO:0006363)4.85518546
34transcription elongation from RNA polymerase I promoter (GO:0006362)4.84291001
35reproduction (GO:0000003)4.78349096
36single fertilization (GO:0007338)4.71809444
37regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.69757011
38regulation of uterine smooth muscle contraction (GO:0070472)4.69071244
39transcription from RNA polymerase I promoter (GO:0006360)4.67851080
40folic acid metabolic process (GO:0046655)4.62515649
41regulation of mitotic spindle organization (GO:0060236)4.61121801
427-methylguanosine mRNA capping (GO:0006370)4.56876473
43folic acid transport (GO:0015884)4.50682269
44negative regulation of Ras GTPase activity (GO:0034261)4.48314120
45female mating behavior (GO:0060180)4.47428527
46RNA capping (GO:0036260)4.45641145
477-methylguanosine RNA capping (GO:0009452)4.45641145
48positive regulation of chromosome segregation (GO:0051984)4.44967607
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.44348312
50binding of sperm to zona pellucida (GO:0007339)4.42616728
51transcription initiation from RNA polymerase I promoter (GO:0006361)4.42013320
52male meiosis (GO:0007140)4.38778040
53protein kinase C signaling (GO:0070528)4.35016732
54lung-associated mesenchyme development (GO:0060484)4.31210282
55aggressive behavior (GO:0002118)4.30583456
56drinking behavior (GO:0042756)4.19749042
57protein localization to kinetochore (GO:0034501)4.18686432
58GMP metabolic process (GO:0046037)4.17820684
59acrosome reaction (GO:0007340)4.16864018
60blastocyst development (GO:0001824)4.05034587
61regulation of female gonad development (GO:2000194)4.04995812
62regulation of penile erection (GO:0060405)4.00127840
63rRNA methylation (GO:0031167)3.97221775
64positive regulation of digestive system process (GO:0060456)3.93934103
65meiosis I (GO:0007127)3.92687215
66maturation of 5.8S rRNA (GO:0000460)3.92028890
67regulation of G0 to G1 transition (GO:0070316)3.90240339
68spindle checkpoint (GO:0031577)3.89986429
69proteasome assembly (GO:0043248)3.88725040
70negative regulation of reproductive process (GO:2000242)3.86079117
71hyperosmotic salinity response (GO:0042538)3.81870254
72ribonucleoprotein complex biogenesis (GO:0022613)3.81589753
73positive regulation of prostaglandin secretion (GO:0032308)3.81387965
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.78545991
75positive regulation of humoral immune response (GO:0002922)3.78478709
76regulation of exit from mitosis (GO:0007096)3.78046498
77establishment of chromosome localization (GO:0051303)3.77558665
78pantothenate metabolic process (GO:0015939)3.75751228
79DNA-templated transcription, elongation (GO:0006354)3.75372479
80microtubule depolymerization (GO:0007019)3.74068209
81transcription elongation from RNA polymerase II promoter (GO:0006368)3.72774668
82negative regulation of digestive system process (GO:0060457)3.68378421
83amino acid salvage (GO:0043102)3.66236204
84L-methionine salvage (GO:0071267)3.66236204
85L-methionine biosynthetic process (GO:0071265)3.66236204
86sleep (GO:0030431)3.65760404
87fertilization (GO:0009566)3.65220570
88protein localization to chromosome, centromeric region (GO:0071459)3.65177394
89rRNA processing (GO:0006364)3.64843048
90spliceosomal snRNP assembly (GO:0000387)3.62736617
91mitotic spindle checkpoint (GO:0071174)3.62289303
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61443002
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61340412
94regulation of translation in response to stress (GO:0043555)3.59311587
95protein K6-linked ubiquitination (GO:0085020)3.58423565
96attachment of spindle microtubules to kinetochore (GO:0008608)3.57356945
97regulation of chromosome segregation (GO:0051983)3.56807316
98rRNA metabolic process (GO:0016072)3.56102964
99positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.55222138
100positive regulation of viral transcription (GO:0050434)3.52935681
101chromosome organization involved in meiosis (GO:0070192)3.51818080
102histone-serine phosphorylation (GO:0035404)3.51534289
103intestinal epithelial cell development (GO:0060576)3.50764721
104glycine metabolic process (GO:0006544)3.50532952
105sperm-egg recognition (GO:0035036)3.50111789
106maturation of SSU-rRNA (GO:0030490)3.45518475
107protein K48-linked deubiquitination (GO:0071108)3.42909490
108CENP-A containing nucleosome assembly (GO:0034080)3.42389967
109serine family amino acid catabolic process (GO:0009071)3.40407756
110response to UV-C (GO:0010225)3.39492265
111negative regulation of chromosome segregation (GO:0051985)3.36536180
112DNA-dependent DNA replication (GO:0006261)3.36378550
113positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.35727631
114formation of translation preinitiation complex (GO:0001731)3.35258774
115positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34797416
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.34398045
117negative regulation of sister chromatid segregation (GO:0033046)3.34398045
118negative regulation of mitotic sister chromatid separation (GO:2000816)3.34398045
119negative regulation of mitotic sister chromatid segregation (GO:0033048)3.34398045
120mitotic spindle assembly checkpoint (GO:0007094)3.33595070
121regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32844382
122autophagic vacuole assembly (GO:0000045)3.32600233
123regulation of meiosis (GO:0040020)3.32245709
124regulation of double-strand break repair via homologous recombination (GO:0010569)3.31281817
125positive regulation of histone H3-K4 methylation (GO:0051571)3.30579305
126S-adenosylmethionine metabolic process (GO:0046500)3.30435293
127mitotic nuclear envelope disassembly (GO:0007077)3.29966746
128male meiosis I (GO:0007141)3.29425131
129DNA deamination (GO:0045006)3.28726556
130spindle assembly checkpoint (GO:0071173)3.28145587
131negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.25012249
132regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24850591
133transcription from RNA polymerase III promoter (GO:0006383)3.24437875
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24007442
135inner cell mass cell proliferation (GO:0001833)3.22795459
136positive regulation of reproductive process (GO:2000243)3.22602313
137meiotic cell cycle (GO:0051321)3.22117128
138histone exchange (GO:0043486)3.21928024
139monoubiquitinated protein deubiquitination (GO:0035520)3.21619723
140regulation of nuclear cell cycle DNA replication (GO:0033262)3.18645404
141regulation of histone H3-K9 methylation (GO:0051570)3.18207031
142regulation of DNA methylation (GO:0044030)3.17336761
143oocyte maturation (GO:0001556)3.16931361
144piRNA metabolic process (GO:0034587)3.16836677
145guanosine-containing compound biosynthetic process (GO:1901070)3.15482660
146chromatin remodeling at centromere (GO:0031055)3.14224606
147regulation of prostaglandin secretion (GO:0032306)3.13894745
148positive regulation of ligase activity (GO:0051351)3.13389127
149kinetochore assembly (GO:0051382)3.13310292
150DNA replication-independent nucleosome organization (GO:0034724)3.12810209
151DNA replication-independent nucleosome assembly (GO:0006336)3.12810209
152methionine metabolic process (GO:0006555)3.11597289
153regulation of helicase activity (GO:0051095)3.10798957
154methionine biosynthetic process (GO:0009086)3.10274949
155regulation of mRNA splicing, via spliceosome (GO:0048024)3.09545702
156meiotic cell cycle process (GO:1903046)3.07635119
157ventricular cardiac muscle cell development (GO:0055015)3.05903366
158calcium ion-dependent exocytosis (GO:0017156)3.05881940
159centriole replication (GO:0007099)3.04855740
160negative regulation of retinoic acid receptor signaling pathway (GO:0048387)24.0283306
161regulation of retinoic acid receptor signaling pathway (GO:0048385)20.1002870
162maternal behavior (GO:0042711)2.99526849
163transcription from mitochondrial promoter (GO:0006390)2.96026647
164citrulline biosynthetic process (GO:0019240)2.86202080
165glycine transport (GO:0015816)2.85515709
166demethylation (GO:0070988)2.85319328
167cell-cell recognition (GO:0009988)2.78692258
168regulation of meiotic cell cycle (GO:0051445)2.76514526
169RNA localization (GO:0006403)2.76253006
170response to prostaglandin (GO:0034694)2.74751353
171regulation of mRNA processing (GO:0050684)2.69745397
172mitochondrial RNA metabolic process (GO:0000959)2.68359476
173N-terminal protein amino acid modification (GO:0031365)2.67904709
174epithelial cilium movement (GO:0003351)2.66058059
175protein K63-linked deubiquitination (GO:0070536)2.64017120
176poly(A)+ mRNA export from nucleus (GO:0016973)2.63171123
177parental behavior (GO:0060746)2.61115332
178meiotic nuclear division (GO:0007126)2.60104818
179spermatid development (GO:0007286)2.60027624
180DNA replication-dependent nucleosome organization (GO:0034723)2.56052724
181DNA replication-dependent nucleosome assembly (GO:0006335)2.56052724
182negative regulation of histone modification (GO:0031057)2.55529465
183regulation of RNA splicing (GO:0043484)2.53996480
184regulation of defense response to virus by host (GO:0050691)2.51892252
185regulation of ruffle assembly (GO:1900027)2.51730180
186cilium movement (GO:0003341)2.50142772
187phosphorelay signal transduction system (GO:0000160)2.49264924
188phosphate ion homeostasis (GO:0055062)2.48070979
189trivalent inorganic anion homeostasis (GO:0072506)2.48070979
190regulation of norepinephrine secretion (GO:0014061)2.46175008
191histone H3-K9 demethylation (GO:0033169)15.8990033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.60552706
2EZH2_22144423_ChIP-Seq_EOC_Human6.36214593
3E2F7_22180533_ChIP-Seq_HELA_Human5.58088112
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.82736927
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.16708030
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08936278
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.83620997
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.68461495
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.63710903
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.62052651
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.55210500
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.54710312
13GABP_17652178_ChIP-ChIP_JURKAT_Human3.48461711
14EST1_17652178_ChIP-ChIP_JURKAT_Human3.25206920
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.21183471
16VDR_22108803_ChIP-Seq_LS180_Human3.10344118
17E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09304082
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98024128
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83879251
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69359592
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.68284634
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66493203
23AR_21909140_ChIP-Seq_LNCAP_Human2.61997894
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59920836
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56126417
26VDR_23849224_ChIP-Seq_CD4+_Human2.55844970
27GBX2_23144817_ChIP-Seq_PC3_Human2.43445422
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.42896700
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.32574164
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.32574164
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.32574164
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32037602
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26411283
34NANOG_18555785_ChIP-Seq_MESCs_Mouse2.17459030
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14521459
36XRN2_22483619_ChIP-Seq_HELA_Human2.08953018
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07129134
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06967036
39IRF1_19129219_ChIP-ChIP_H3396_Human2.05712409
40GABP_19822575_ChIP-Seq_HepG2_Human2.04507310
41IGF1R_20145208_ChIP-Seq_DFB_Human2.02122243
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.01812808
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98014254
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97963249
45FOXP3_21729870_ChIP-Seq_TREG_Human1.88445532
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87722552
47MYC_18940864_ChIP-ChIP_HL60_Human1.87514814
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.86744017
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81187542
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.77554721
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76496385
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75720780
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72969132
54DCP1A_22483619_ChIP-Seq_HELA_Human1.72705394
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71587998
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.71517923
57* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.70625898
58KDM5A_27292631_Chip-Seq_BREAST_Human1.66385486
59ZNF274_21170338_ChIP-Seq_K562_Hela1.66058679
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65687490
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.64732493
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63958301
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62812314
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60820974
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60338441
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57510581
67ZNF263_19887448_ChIP-Seq_K562_Human1.57001516
68TCF4_23295773_ChIP-Seq_U87_Human1.55804676
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55230588
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.54948400
71RNF2_27304074_Chip-Seq_NSC_Mouse1.54733246
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.52823535
73CBP_21632823_ChIP-Seq_H3396_Human1.52055224
74TTF2_22483619_ChIP-Seq_HELA_Human1.47642395
75* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46655283
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.45023514
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44497204
78ELK1_19687146_ChIP-ChIP_HELA_Human1.44480606
79TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.43141651
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42006393
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.40411506
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.39457303
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38988011
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.36426273
85STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.36360042
86NCOR_22424771_ChIP-Seq_293T_Human1.36359170
87STAT3_23295773_ChIP-Seq_U87_Human1.35307177
88RXR_22108803_ChIP-Seq_LS180_Human1.32407927
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32231051
90AR_25329375_ChIP-Seq_VCAP_Human1.32084379
91* SMAD4_21799915_ChIP-Seq_A2780_Human1.31751634
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.30674878
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29214589
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27815527
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.26086108
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25079004
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.24200032
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.22988756
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22870677
100SMAD3_21741376_ChIP-Seq_HESCs_Human1.22860138
101GATA3_26560356_Chip-Seq_TH1_Human1.22460848
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20660089
103GF1_26923725_Chip-Seq_HPCs_Mouse1.20657063
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20612345
105P300_19829295_ChIP-Seq_ESCs_Human1.19494351
106RAC3_21632823_ChIP-Seq_H3396_Human1.18673597
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.18283879
108ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17220012
109GATA1_26923725_Chip-Seq_HPCs_Mouse1.16207265
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15450120
111SMAD4_21741376_ChIP-Seq_HESCs_Human1.14455973
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14183971
113CIITA_25753668_ChIP-Seq_RAJI_Human1.12046514
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11566964
115STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10946599
116BCAT_22108803_ChIP-Seq_LS180_Human1.09743814
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09203146
118TCF4_22108803_ChIP-Seq_LS180_Human1.07557584
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07281025
120SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07217310
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06855113
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06073139
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05506062
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04973786
125JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04900181
126HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04021420
127ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03731801
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02144643
129POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01722268
130SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00231103
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98426205
132TAF15_26573619_Chip-Seq_HEK293_Human0.97849047
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97752801
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96850456
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96617191
136TP53_22573176_ChIP-Seq_HFKS_Human0.96602570
137KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95054795
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92725972
139* RUNX2_22187159_ChIP-Seq_PCA_Human0.92145347
140ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92007194
141ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91332643
142KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91281020
143NANOG_21062744_ChIP-ChIP_HESCs_Human0.90502241
144CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90433146
145CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90301537
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90061923
147NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89623240
148DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87930701
149LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87799058
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87629709
151JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87053835
152PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87012012
153SOX2_16153702_ChIP-ChIP_HESCs_Human0.85453908
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.85303044
155NANOG_20526341_ChIP-Seq_ESCs_Human0.84891082
156FOXH1_21741376_ChIP-Seq_EPCs_Human0.84752897
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84538660
158KAP1_27257070_Chip-Seq_ESCs_Mouse0.84504689
159TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83647753
160EZH2_27294783_Chip-Seq_ESCs_Mouse0.82845186
161POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81134484
162POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.80412462
163SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80410063
164TBL1_22424771_ChIP-Seq_293T_Human0.79712694
165FLI1_27457419_Chip-Seq_LIVER_Mouse0.79672858
166CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75861951
167SOX2_18555785_ChIP-Seq_MESCs_Mouse0.75745212
168SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73871891
169KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73792652
170CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72960045
171NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72162962
172SOX17_20123909_ChIP-Seq_XEN_Mouse0.71611507
173FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71315991
174EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.70522089
175CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69865448
176SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69623073
177OCT4_18692474_ChIP-Seq_MEFs_Mouse0.67931473
178FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.67215077
179HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.66328760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.87274527
2MP0003111_abnormal_nucleus_morphology5.17412742
3MP0003718_maternal_effect5.01815078
4MP0003283_abnormal_digestive_organ4.49811368
5MP0009379_abnormal_foot_pigmentation4.24482648
6MP0008260_abnormal_autophagy4.18846968
7MP0010094_abnormal_chromosome_stability3.91644330
8MP0004957_abnormal_blastocyst_morpholog3.88721535
9MP0003950_abnormal_plasma_membrane3.82541212
10MP0003077_abnormal_cell_cycle3.72455688
11MP0008057_abnormal_DNA_replication3.68057945
12MP0005410_abnormal_fertilization3.42774333
13MP0000678_abnormal_parathyroid_gland3.19958461
14MP0008058_abnormal_DNA_repair3.18841690
15MP0003786_premature_aging2.82575154
16MP0006276_abnormal_autonomic_nervous2.65269757
17MP0003123_paternal_imprinting2.65026796
18MP0008007_abnormal_cellular_replicative2.53423827
19MP0009840_abnormal_foam_cell2.45176505
20MP0005360_urolithiasis2.43658923
21MP0008932_abnormal_embryonic_tissue2.34689796
22MP0000427_abnormal_hair_cycle2.32962280
23MP0001502_abnormal_circadian_rhythm2.32154306
24MP0008877_abnormal_DNA_methylation2.25037511
25MP0001730_embryonic_growth_arrest2.23120799
26MP0001661_extended_life_span2.11565280
27MP0005377_hearing/vestibular/ear_phenot2.10638214
28MP0003878_abnormal_ear_physiology2.10638214
29MP0005451_abnormal_body_composition1.99422267
30MP0000350_abnormal_cell_proliferation1.84869931
31MP0005647_abnormal_sex_gland1.84470639
32MP0003119_abnormal_digestive_system1.81398175
33MP0002396_abnormal_hematopoietic_system1.80110438
34MP0001542_abnormal_bone_strength1.78674395
35MP0005395_other_phenotype1.75708655
36MP0006292_abnormal_olfactory_placode1.75589259
37MP0001672_abnormal_embryogenesis/_devel1.75531948
38MP0005380_embryogenesis_phenotype1.75531948
39MP0010307_abnormal_tumor_latency1.75355620
40MP0005220_abnormal_exocrine_pancreas1.74360969
41MP0003315_abnormal_perineum_morphology1.72827241
42MP0003890_abnormal_embryonic-extraembry1.66769388
43MP0002751_abnormal_autonomic_nervous1.65496989
44MP0000049_abnormal_middle_ear1.65368497
45MP0001666_abnormal_nutrient_absorption1.61532129
46MP0009333_abnormal_splenocyte_physiolog1.60989066
47MP0001664_abnormal_digestion1.59756697
48MP0005646_abnormal_pituitary_gland1.57071147
49MP0003938_abnormal_ear_development1.56942859
50MP0002210_abnormal_sex_determination1.56518213
51MP0003866_abnormal_defecation1.56042903
52MP0003984_embryonic_growth_retardation1.44707223
53MP0003868_abnormal_feces_composition1.44693071
54MP0004233_abnormal_muscle_weight1.43870499
55MP0002088_abnormal_embryonic_growth/wei1.40089120
56MP0001929_abnormal_gametogenesis1.36399774
57MP0002080_prenatal_lethality1.35699419
58MP0003221_abnormal_cardiomyocyte_apopto1.35653815
59MP0001145_abnormal_male_reproductive1.33738715
60MP0005394_taste/olfaction_phenotype1.29501533
61MP0005499_abnormal_olfactory_system1.29501533
62MP0001697_abnormal_embryo_size1.29390274
63MP0002132_abnormal_respiratory_system1.28069341
64MP0000653_abnormal_sex_gland1.25056120
65MP0003183_abnormal_peptide_metabolism1.23801130
66MP0000750_abnormal_muscle_regeneration1.23239017
67MP0003941_abnormal_skin_development1.19510329
68MP0003567_abnormal_fetal_cardiomyocyte1.16293023
69MP0009672_abnormal_birth_weight1.16167997
70MP0005397_hematopoietic_system_phenotyp1.12372630
71MP0001545_abnormal_hematopoietic_system1.12372630
72MP0002102_abnormal_ear_morphology1.10984639
73MP0000372_irregular_coat_pigmentation1.10273822
74MP0002163_abnormal_gland_morphology1.08989339
75MP0002085_abnormal_embryonic_tissue1.07545585
76MP0001881_abnormal_mammary_gland1.07415586
77MP0005423_abnormal_somatic_nervous1.06973274
78MP0001986_abnormal_taste_sensitivity1.06827901
79MP0001440_abnormal_grooming_behavior1.04078131
80MP0000313_abnormal_cell_death1.01810218
81MP0003121_genomic_imprinting1.01415282
82MP0003699_abnormal_female_reproductive1.00874942
83MP0003879_abnormal_hair_cell0.99978099
84MP0003937_abnormal_limbs/digits/tail_de0.96974358
85MP0008995_early_reproductive_senescence0.96928568
86MP0000470_abnormal_stomach_morphology0.95585751
87MP0000631_abnormal_neuroendocrine_gland0.95252499
88MP0001119_abnormal_female_reproductive0.93696289
89MP0002086_abnormal_extraembryonic_tissu0.92675711
90MP0006072_abnormal_retinal_apoptosis0.91849848
91MP0004019_abnormal_vitamin_homeostasis0.91621747
92MP0005621_abnormal_cell_physiology0.90829570
93MP0000627_abnormal_mammary_gland0.90427872
94MP0003136_yellow_coat_color0.90347544
95MP0002160_abnormal_reproductive_system0.88489518
96MP0005076_abnormal_cell_differentiation0.88213534
97MP0001286_abnormal_eye_development0.88027188
98MP0001756_abnormal_urination0.87764432
99MP0005389_reproductive_system_phenotype0.87356122
100MP0001293_anophthalmia0.86121029
101MP0008789_abnormal_olfactory_epithelium0.85943143
102MP0010030_abnormal_orbit_morphology0.83408004
103MP0000647_abnormal_sebaceous_gland0.83121019
104MP0000383_abnormal_hair_follicle0.82381877
105MP0004043_abnormal_pH_regulation0.81818996
106MP0002090_abnormal_vision0.81380251
107MP0005384_cellular_phenotype0.80791507
108MP0002084_abnormal_developmental_patter0.80357361
109MP0002161_abnormal_fertility/fecundity0.79875306
110MP0004885_abnormal_endolymph0.79787208
111MP0004742_abnormal_vestibular_system0.79562534
112MP0003698_abnormal_male_reproductive0.78421332
113MP0001764_abnormal_homeostasis0.76760952
114MP0000230_abnormal_systemic_arterial0.75231963
115MP0000462_abnormal_digestive_system0.75031397
116MP0002184_abnormal_innervation0.74539720
117MP0009703_decreased_birth_body0.74229816
118MP0002229_neurodegeneration0.73710998
119MP0005408_hypopigmentation0.73399050
120MP0000428_abnormal_craniofacial_morphol0.73326947
121MP0002019_abnormal_tumor_incidence0.71684711
122MP0004270_analgesia0.71410819
123MP0005332_abnormal_amino_acid0.71231296
124MP0004084_abnormal_cardiac_muscle0.70094175
125MP0010368_abnormal_lymphatic_system0.69272540
126MP0000358_abnormal_cell_content/0.68779870
127MP0002272_abnormal_nervous_system0.68259811
128MP0000534_abnormal_ureter_morphology0.67104434
129MP0000778_abnormal_nervous_system0.66970826
130MP0002277_abnormal_respiratory_mucosa0.65216785
131MP0003656_abnormal_erythrocyte_physiolo0.64816410
132MP0002653_abnormal_ependyma_morphology0.62969134
133MP0005551_abnormal_eye_electrophysiolog0.62444768
134MP0002092_abnormal_eye_morphology0.62011997
135MP0003936_abnormal_reproductive_system0.61241512
136MP0000747_muscle_weakness0.59976065
137MP0005197_abnormal_uvea_morphology0.59619128
138MP0004381_abnormal_hair_follicle0.59249079
139MP0004142_abnormal_muscle_tone0.58811901
140MP0001944_abnormal_pancreas_morphology0.58530035
141MP0004808_abnormal_hematopoietic_stem0.54993851
142MP0005058_abnormal_lysosome_morphology0.52732662
143MP0002127_abnormal_cardiovascular_syste0.52598250
144MP0002249_abnormal_larynx_morphology0.52384994
145MP0002938_white_spotting0.51978382
146MP0003959_abnormal_lean_body0.51705805
147MP0006035_abnormal_mitochondrial_morpho0.51353888
148MP0009384_cardiac_valve_regurgitation0.50855823
149MP0001485_abnormal_pinna_reflex0.50438609
150MP0000490_abnormal_crypts_of0.50338103
151MP0001501_abnormal_sleep_pattern0.50051361
152MP0001529_abnormal_vocalization0.49863274
153MP0002233_abnormal_nose_morphology0.49736136
154MP0004197_abnormal_fetal_growth/weight/0.49007295
155MP0001919_abnormal_reproductive_system0.48968882
156MP0003935_abnormal_craniofacial_develop0.47629184
157MP0006138_congestive_heart_failure0.47212429
158MP0005310_abnormal_salivary_gland0.47120597
159MP0003828_pulmonary_edema0.45195609

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)6.23166611
2Birth length less than 3rd percentile (HP:0003561)5.88821672
3Impulsivity (HP:0100710)5.65970182
4Breast hypoplasia (HP:0003187)5.41034258
5Median cleft lip (HP:0000161)5.03616680
6Cerebral hypomyelination (HP:0006808)4.87703156
7Hyperglycinuria (HP:0003108)4.83677798
8Short tibia (HP:0005736)4.74908934
9Aplasia/Hypoplasia of the tibia (HP:0005772)4.54534674
10Microglossia (HP:0000171)4.54218371
11Carpal bone hypoplasia (HP:0001498)4.48291172
12Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.37588803
13Facial cleft (HP:0002006)4.26262716
14Rough bone trabeculation (HP:0100670)4.21648555
15Abnormal number of incisors (HP:0011064)4.12922131
16Abnormality of glycine metabolism (HP:0010895)3.88852379
17Abnormality of serine family amino acid metabolism (HP:0010894)3.88852379
18Entropion (HP:0000621)3.88820291
19Patellar aplasia (HP:0006443)3.84422537
20Aplasia/Hypoplasia of the patella (HP:0006498)3.81350555
21Abdominal situs inversus (HP:0003363)3.76399217
22Abnormality of abdominal situs (HP:0011620)3.76399217
23Ureteral duplication (HP:0000073)3.75864234
24Tetraparesis (HP:0002273)3.57557482
25Metaphyseal dysplasia (HP:0100255)3.54272337
26Atonic seizures (HP:0010819)3.45451529
27Abnormality of the nasal septum (HP:0000419)3.42711443
28Abnormal auditory evoked potentials (HP:0006958)3.40820376
29Congenital sensorineural hearing impairment (HP:0008527)3.33587638
30Abnormality of the labia minora (HP:0012880)3.28741181
31Abnormality of the umbilical cord (HP:0010881)3.24751998
32Atrioventricular block (HP:0001678)3.23313771
33Gout (HP:0001997)3.18887037
34Abnormal trabecular bone morphology (HP:0100671)3.17315055
35Hyperphosphatemia (HP:0002905)3.16724223
36Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.15882680
37Abnormality of serum amino acid levels (HP:0003112)3.15199459
38Bundle branch block (HP:0011710)3.11870320
39Multiple enchondromatosis (HP:0005701)3.10023518
40Abnormal spermatogenesis (HP:0008669)3.09998885
41Tetany (HP:0001281)3.06871504
42Adrenal hypoplasia (HP:0000835)3.06705867
43CNS hypomyelination (HP:0003429)3.03489549
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.03066339
45Myokymia (HP:0002411)3.02913100
46Oligodactyly (hands) (HP:0001180)3.01565990
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.94390820
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.94355361
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.94355361
50Ventricular fibrillation (HP:0001663)2.92967249
51Secondary amenorrhea (HP:0000869)2.90880925
52Amelogenesis imperfecta (HP:0000705)2.90603794
53Glossoptosis (HP:0000162)2.88155346
54Maternal diabetes (HP:0009800)2.87715585
55Rhinitis (HP:0012384)2.84634997
56Hypoplasia of the capital femoral epiphysis (HP:0003090)2.75928255
57Absent radius (HP:0003974)2.75513006
58Abnormality of the preputium (HP:0100587)2.75356549
59Meckel diverticulum (HP:0002245)2.71973956
60Pustule (HP:0200039)2.71563761
61Progressive muscle weakness (HP:0003323)2.69120503
62Short chin (HP:0000331)2.68510930
63Muscle fiber splitting (HP:0003555)2.68166642
64Abnormality of the corticospinal tract (HP:0002492)2.67911998
65Anterior segment dysgenesis (HP:0007700)2.65932583
66Chromsome breakage (HP:0040012)2.65472909
67Tetraplegia (HP:0002445)2.64085783
68Death in infancy (HP:0001522)2.63715078
69Aplasia/Hypoplasia involving the musculature (HP:0001460)2.63311216
70Neurofibrillary tangles (HP:0002185)2.61978271
71Premature ovarian failure (HP:0008209)2.60410103
72Absent forearm bone (HP:0003953)2.58265171
73Aplasia involving forearm bones (HP:0009822)2.58265171
74Degeneration of anterior horn cells (HP:0002398)2.58132025
75Abnormality of the anterior horn cell (HP:0006802)2.58132025
76Abnormality of calcium-phosphate metabolism (HP:0100530)2.57488147
77Azoospermia (HP:0000027)2.57225416
78Glucose intolerance (HP:0000833)2.55161267
79Areflexia of lower limbs (HP:0002522)2.54571063
80Premature rupture of membranes (HP:0001788)2.52747440
81Delusions (HP:0000746)2.51353892
82Irregular epiphyses (HP:0010582)2.50981566
83Short nail (HP:0001799)2.50422641
84Mutism (HP:0002300)2.49701384
85Congenital, generalized hypertrichosis (HP:0004540)2.49694935
86Oligodactyly (HP:0012165)2.48467343
87Submucous cleft hard palate (HP:0000176)2.47832482
88Loss of speech (HP:0002371)2.47243849
89Abnormality of the ileum (HP:0001549)2.46608187
90Reticulocytopenia (HP:0001896)2.46559320
91Autoimmune thrombocytopenia (HP:0001973)2.45787726
92Abnormal ciliary motility (HP:0012262)2.43438776
93Sparse eyelashes (HP:0000653)2.42139920
94Prolonged neonatal jaundice (HP:0006579)2.41998771
95Abnormality of lateral ventricle (HP:0030047)2.41889798
96Facial hemangioma (HP:0000329)2.40837153
97Aplasia/Hypoplasia of the tongue (HP:0010295)2.40081169
98Ectopic kidney (HP:0000086)2.39871902
99Restlessness (HP:0000711)2.39681065
100Breast aplasia (HP:0100783)2.38811997
101Type I diabetes mellitus (HP:0100651)2.38803767
102Stillbirth (HP:0003826)2.34971785
103Abnormal pancreas size (HP:0012094)2.34553166
104Capillary hemangiomas (HP:0005306)2.34278173
105Microretrognathia (HP:0000308)2.34153359
106Dysautonomia (HP:0002459)2.33467463
107Anhidrosis (HP:0000970)2.33390577
108Oral leukoplakia (HP:0002745)2.31734285
109Horseshoe kidney (HP:0000085)2.31515350
110Abnormality of the distal phalanges of the toes (HP:0010182)2.30249705
111Malnutrition (HP:0004395)2.29915510
112Sensory axonal neuropathy (HP:0003390)2.28438590
113Abnormality of the incisor (HP:0000676)2.28386121
114Abnormality of chromosome stability (HP:0003220)2.27008479
115Aplasia/Hypoplasia of the breasts (HP:0010311)2.26783278
116Abnormality of dental color (HP:0011073)2.26701092
117Hypophosphatemic rickets (HP:0004912)2.26230633
118Osteolytic defects of the phalanges of the hand (HP:0009771)2.26170679
119Osteolytic defects of the hand bones (HP:0009699)2.26170679
120Aplasia/Hypoplasia of the fovea (HP:0008060)2.24324504
121Hypoplasia of the fovea (HP:0007750)2.24324504
122Megaloblastic anemia (HP:0001889)2.24093415
123Infertility (HP:0000789)2.22534687
124Pancreatic fibrosis (HP:0100732)2.18766017
125Bone marrow hypocellularity (HP:0005528)2.18697751
126Aplasia/Hypoplasia of the uvula (HP:0010293)2.16517056
127Abnormal respiratory motile cilium physiology (HP:0012261)2.15973885
128Flat capital femoral epiphysis (HP:0003370)2.15024121
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.14503208
130Absent epiphyses (HP:0010577)2.14503208
131Abnormalities of placenta or umbilical cord (HP:0001194)2.12064852
132Sparse lateral eyebrow (HP:0005338)2.11198121
133Aplasia/Hypoplasia of the earlobes (HP:0009906)2.10089455
134Brittle hair (HP:0002299)2.09955310
135Small epiphyses (HP:0010585)2.07572962
136Personality changes (HP:0000751)2.07502012
137Patent foramen ovale (HP:0001655)2.07259025
138Reduced subcutaneous adipose tissue (HP:0003758)2.03187408
139Male infertility (HP:0003251)2.03106508
140Heart block (HP:0012722)2.02244400
141Type 2 muscle fiber atrophy (HP:0003554)2.01075159
142Segmental peripheral demyelination/remyelination (HP:0003481)2.00885116
143Pili torti (HP:0003777)1.99282016
144Pelvic girdle muscle weakness (HP:0003749)1.99023477
145Small intestinal stenosis (HP:0012848)1.99021798
146Duodenal stenosis (HP:0100867)1.99021798
147Abnormality of alanine metabolism (HP:0010916)1.98423827
148Hyperalaninemia (HP:0003348)1.98423827
149Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98423827
150Spinal muscular atrophy (HP:0007269)1.98290988
151Hyperglycemia (HP:0003074)1.97890446
152Bony spicule pigmentary retinopathy (HP:0007737)1.96693821
153Osteomalacia (HP:0002749)1.96119519
154Dynein arm defect of respiratory motile cilia (HP:0012255)1.94458299
155Absent/shortened dynein arms (HP:0200106)1.94458299
156Hypoplasia of the radius (HP:0002984)1.93467756
157Absent thumb (HP:0009777)1.93391227
158Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91772507
159Apathy (HP:0000741)1.91554781
160Exertional dyspnea (HP:0002875)1.89250949
161Chronic bronchitis (HP:0004469)1.88798014
162Optic nerve hypoplasia (HP:0000609)1.84412297
163Cleft eyelid (HP:0000625)1.83240263
164Genu varum (HP:0002970)1.83006920
165Renal Fanconi syndrome (HP:0001994)1.82849990
166Short middle phalanx of the 5th finger (HP:0004220)1.77163404
167Disproportionate short-trunk short stature (HP:0003521)1.76991561
168Selective tooth agenesis (HP:0001592)1.76945245
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76781191
170Short thumb (HP:0009778)1.76431682
171Increased hepatocellular lipid droplets (HP:0006565)1.73826963
172Partial agenesis of the corpus callosum (HP:0001338)1.71032031
173Abnormality of purine metabolism (HP:0004352)1.68222945
174Abnormality of sulfur amino acid metabolism (HP:0004339)1.67744467
175Aplasia/Hypoplasia of the sternum (HP:0006714)1.67552832
176Hypokinesia (HP:0002375)1.67320848
177Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.67260899
178Steatorrhea (HP:0002570)1.64476823
179Preauricular pit (HP:0004467)1.63228999
180Periauricular skin pits (HP:0100277)1.63228999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.96946723
2WEE14.96431004
3CDK124.04975583
4CDK193.91820422
5TNIK3.44348885
6EIF2AK13.38202824
7AKT33.34421495
8TSSK63.24884025
9PLK43.17422812
10BRSK23.15692524
11MKNK22.65708756
12NEK22.60825931
13STK162.60047203
14SRPK12.57257683
15TAOK32.44467456
16PLK32.43805014
17EIF2AK32.23315866
18PLK12.15186844
19BRSK12.12891023
20NME22.08966195
21MKNK12.01899229
22PINK11.92095911
23CCNB11.92010640
24STK391.90414240
25TTK1.86903986
26ACVR1B1.83184666
27ZAK1.80701169
28DYRK31.69895873
29IRAK31.64979748
30PNCK1.61248317
31ICK1.59718038
32TRIM281.56078689
33EPHA21.49126249
34NEK11.45361974
35LATS21.44877178
36ARAF1.38982609
37STK38L1.37247397
38WNK11.36591987
39PDK31.36032364
40PDK41.36032364
41CHEK21.32656558
42PBK1.30951047
43AURKB1.29764494
44TEC1.29572190
45STK31.28369403
46NLK1.26675962
47BMPR1B1.24217565
48PKN11.23979433
49EIF2AK21.22842819
50PDK21.20569676
51CDC71.15343335
52BRAF1.12214366
53MAP3K31.11844238
54VRK11.10355584
55MAP2K31.09951447
56AURKA1.01988016
57EPHA41.01605462
58ALK0.93720525
59PLK20.93141947
60PIM20.90543809
61CHEK10.90442872
62CDK70.89434542
63NUAK10.89430623
64OXSR10.88951587
65CDK30.85231492
66VRK20.81006793
67RPS6KA40.77493590
68CDK40.76983375
69NEK60.76555404
70PRKCI0.75960020
71MARK20.72723528
72SGK20.71243886
73ATR0.69970156
74BRD40.68632971
75MARK30.67318741
76STK240.67150869
77MAP3K80.63181071
78CSNK1G30.62252054
79CDK20.61693432
80PAK10.58163171
81PIK3CA0.57054782
82TESK20.56543062
83PRKAA10.55723192
84MOS0.52638176
85LATS10.52281506
86GRK70.52089493
87CAMK40.52047733
88CSNK2A10.51700124
89NME10.51218979
90CSNK1G10.50982855
91CDK10.50182618
92MELK0.49735853
93PIK3CG0.49023011
94DYRK20.48378287
95MAPKAPK20.48223596
96STK40.47957504
97PIM10.46900204
98DMPK0.45969524
99MAP3K50.45633428
100CSNK2A20.44801334
101CSNK1A1L0.44566343
102CSNK1E0.44485028
103WNK30.44217198
104WNK40.43468411
105ATM0.42214837
106PRKCG0.41275504
107CSNK1D0.40494435
108MAPK130.39862746
109GRK50.39509312
110CAMK10.38306877
111PRKD10.36700076
112CSNK1G20.36175027
113CDK90.33487212
114STK380.32658584
115CAMK1D0.32610050
116CSNK1A10.32578152
117GSK3A0.32569669
118PRKACA0.31752799
119RPS6KA50.30542244
120PDK10.30127678
121RAF10.29854286
122ABL20.28987975
123SGK2230.28375848
124SGK4940.28375848
125ILK0.28007839
126PRKACB0.26857387
127NTRK20.26664933
128TGFBR10.26389393
129CAMKK20.25512199
130MAPK10.24340125
131TLK10.22973988
132MAP2K20.17141778
133MAPK100.15463083
134MARK10.13175784
135IKBKB0.13051270
136GRK10.12673973
137AKT20.11753640
138MAPK40.10486824
139GSK3B0.09866513
140MAP3K90.07998863
141MAPK90.07485273
142CAMK2G0.07363062
143IRAK40.05776478
144MAPK80.05342259
145DYRK1A0.05334834
146MAPK140.05119657
147CDK80.04868799
148MTOR0.04832437

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.36017608
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005336.86855873
3RNA polymerase_Homo sapiens_hsa030205.41071899
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.73031921
5Proteasome_Homo sapiens_hsa030503.34083992
6RNA transport_Homo sapiens_hsa030133.25332675
7Dorso-ventral axis formation_Homo sapiens_hsa043202.98544868
8Pyrimidine metabolism_Homo sapiens_hsa002402.67987655
9Regulation of autophagy_Homo sapiens_hsa041402.62818925
10Cell cycle_Homo sapiens_hsa041102.53506284
11Basal transcription factors_Homo sapiens_hsa030222.43814937
12Spliceosome_Homo sapiens_hsa030402.41463227
13DNA replication_Homo sapiens_hsa030302.27676984
14Bile secretion_Homo sapiens_hsa049762.10442361
15Homologous recombination_Homo sapiens_hsa034402.10233721
16Folate biosynthesis_Homo sapiens_hsa007902.08952317
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03244068
18Fatty acid biosynthesis_Homo sapiens_hsa000612.02462820
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.00875136
20Sulfur metabolism_Homo sapiens_hsa009201.98978897
21Purine metabolism_Homo sapiens_hsa002301.90926240
22Vitamin digestion and absorption_Homo sapiens_hsa049771.82445773
23Nucleotide excision repair_Homo sapiens_hsa034201.78233817
24Fanconi anemia pathway_Homo sapiens_hsa034601.76465538
25Mismatch repair_Homo sapiens_hsa034301.75268084
26p53 signaling pathway_Homo sapiens_hsa041151.73981866
27Ovarian steroidogenesis_Homo sapiens_hsa049131.73153413
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.68066231
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56402681
30Base excision repair_Homo sapiens_hsa034101.56237452
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48257401
32Pentose phosphate pathway_Homo sapiens_hsa000301.46146197
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44887707
34Olfactory transduction_Homo sapiens_hsa047401.44199180
35Ribosome_Homo sapiens_hsa030101.41487445
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.34197316
37Oocyte meiosis_Homo sapiens_hsa041141.32019984
38Epstein-Barr virus infection_Homo sapiens_hsa051691.24542663
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.23868638
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22680943
41RNA degradation_Homo sapiens_hsa030181.16224780
42Taste transduction_Homo sapiens_hsa047421.15694981
43Systemic lupus erythematosus_Homo sapiens_hsa053221.11383536
44mRNA surveillance pathway_Homo sapiens_hsa030151.09341507
45Phototransduction_Homo sapiens_hsa047441.07998688
46Insulin secretion_Homo sapiens_hsa049111.02220024
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00584968
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99006930
49Alcoholism_Homo sapiens_hsa050340.96986808
50Tryptophan metabolism_Homo sapiens_hsa003800.96178197
51Serotonergic synapse_Homo sapiens_hsa047260.90572570
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89942385
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84624345
54Biosynthesis of amino acids_Homo sapiens_hsa012300.83365366
55Hedgehog signaling pathway_Homo sapiens_hsa043400.79732234
56One carbon pool by folate_Homo sapiens_hsa006700.78387052
57Circadian rhythm_Homo sapiens_hsa047100.74152439
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70655114
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69938891
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63787582
61Chemical carcinogenesis_Homo sapiens_hsa052040.63508919
62Sulfur relay system_Homo sapiens_hsa041220.60990785
63GABAergic synapse_Homo sapiens_hsa047270.60438583
64Fructose and mannose metabolism_Homo sapiens_hsa000510.57498113
65Lysine degradation_Homo sapiens_hsa003100.55659327
66Tight junction_Homo sapiens_hsa045300.54332453
67Sphingolipid metabolism_Homo sapiens_hsa006000.51089891
68Metabolic pathways_Homo sapiens_hsa011000.48763539
69Nicotine addiction_Homo sapiens_hsa050330.48657884
70Wnt signaling pathway_Homo sapiens_hsa043100.48655777
71Non-homologous end-joining_Homo sapiens_hsa034500.47915156
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47686611
73Morphine addiction_Homo sapiens_hsa050320.47613079
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.46750041
75Cholinergic synapse_Homo sapiens_hsa047250.46267194
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46182619
77cAMP signaling pathway_Homo sapiens_hsa040240.45340955
78Antigen processing and presentation_Homo sapiens_hsa046120.45296542
79Gap junction_Homo sapiens_hsa045400.42355362
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.41513718
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41316962
82Arginine and proline metabolism_Homo sapiens_hsa003300.40073919
83Selenocompound metabolism_Homo sapiens_hsa004500.39816666
84Colorectal cancer_Homo sapiens_hsa052100.39234168
85FoxO signaling pathway_Homo sapiens_hsa040680.38052762
86Arachidonic acid metabolism_Homo sapiens_hsa005900.37270938
87Herpes simplex infection_Homo sapiens_hsa051680.37130549
88TGF-beta signaling pathway_Homo sapiens_hsa043500.36994101
89Linoleic acid metabolism_Homo sapiens_hsa005910.36351093
90Cocaine addiction_Homo sapiens_hsa050300.35813855
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34907392
92Protein digestion and absorption_Homo sapiens_hsa049740.33891796
93Glycerolipid metabolism_Homo sapiens_hsa005610.33869031
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33575053
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32837867
96Glutathione metabolism_Homo sapiens_hsa004800.32662678
97Lysosome_Homo sapiens_hsa041420.31403817
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31272100
99Mineral absorption_Homo sapiens_hsa049780.29207630
100Calcium signaling pathway_Homo sapiens_hsa040200.28860074
101Dopaminergic synapse_Homo sapiens_hsa047280.28749797
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28574844
103Viral carcinogenesis_Homo sapiens_hsa052030.26329832
104Legionellosis_Homo sapiens_hsa051340.26201908
105Synaptic vesicle cycle_Homo sapiens_hsa047210.25798045
106Carbon metabolism_Homo sapiens_hsa012000.25742351
107Steroid biosynthesis_Homo sapiens_hsa001000.24498669
108Pancreatic secretion_Homo sapiens_hsa049720.22287418
109Amphetamine addiction_Homo sapiens_hsa050310.21484992
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20464951
111Butanoate metabolism_Homo sapiens_hsa006500.19993867
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19989955
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19898069
114Cardiac muscle contraction_Homo sapiens_hsa042600.19466996
115beta-Alanine metabolism_Homo sapiens_hsa004100.19273907
116Ether lipid metabolism_Homo sapiens_hsa005650.19147803
117Adherens junction_Homo sapiens_hsa045200.19068610
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.18870786
119Starch and sucrose metabolism_Homo sapiens_hsa005000.17572330
120Circadian entrainment_Homo sapiens_hsa047130.17200729
121ABC transporters_Homo sapiens_hsa020100.16452700
122mTOR signaling pathway_Homo sapiens_hsa041500.16227047
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15555677
124Renin-angiotensin system_Homo sapiens_hsa046140.15205875
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14673063
126Inositol phosphate metabolism_Homo sapiens_hsa005620.14252136
127Thyroid hormone synthesis_Homo sapiens_hsa049180.12946816
128Basal cell carcinoma_Homo sapiens_hsa052170.12675818
129AMPK signaling pathway_Homo sapiens_hsa041520.12585609
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.11549258
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11536917
132Retinol metabolism_Homo sapiens_hsa008300.11482138
133HTLV-I infection_Homo sapiens_hsa051660.10851578
134Rheumatoid arthritis_Homo sapiens_hsa053230.09344070
135Small cell lung cancer_Homo sapiens_hsa052220.09066116
136Huntingtons disease_Homo sapiens_hsa050160.08747997
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.07218470
138MicroRNAs in cancer_Homo sapiens_hsa052060.06552790
139Renal cell carcinoma_Homo sapiens_hsa052110.05940565
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05234259
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.05234230
142Protein export_Homo sapiens_hsa030600.03986326
143HIF-1 signaling pathway_Homo sapiens_hsa040660.03798708
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.02696712
145Apoptosis_Homo sapiens_hsa042100.01798161
146Galactose metabolism_Homo sapiens_hsa000520.01321028
147Maturity onset diabetes of the young_Homo sapiens_hsa049500.00975310
148Thyroid cancer_Homo sapiens_hsa05216-0.0649637
149Prion diseases_Homo sapiens_hsa05020-0.0643932
150Prostate cancer_Homo sapiens_hsa05215-0.0446611
151Collecting duct acid secretion_Homo sapiens_hsa04966-0.0431100
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0395211
153Hippo signaling pathway_Homo sapiens_hsa04390-0.0211293
154Influenza A_Homo sapiens_hsa05164-0.0183158
155Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0108489

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