ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	leukotriene biosynthetic process (GO:0019370)	9.48856977
2	oocyte development (GO:0048599)	7.23328457
3	leukotriene metabolic process (GO:0006691)	6.67805833
4	multicellular organism reproduction (GO:0032504)	6.57682911
5	regulation of acrosome reaction (GO:0060046)	5.99092367
6	histone lysine demethylation (GO:0070076)	5.60049900
7	positive regulation of catecholamine secretion (GO:0033605)	5.24946171
8	histone demethylation (GO:0016577)	5.24065571
9	N-terminal protein amino acid acetylation (GO:0006474)	5.00560543
10	male meiosis I (GO:0007141)	4.95777642
11	regulation of RIG-I signaling pathway (GO:0039535)	4.95062821
12	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	4.94037609
13	icosanoid biosynthetic process (GO:0046456)	4.93772958
14	fatty acid derivative biosynthetic process (GO:1901570)	4.93772958
15	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.91405793
16	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.76845710
17	protein dealkylation (GO:0008214)	4.68009782
18	protein demethylation (GO:0006482)	4.68009782
19	regulation of exit from mitosis (GO:0007096)	4.51354263
20	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	4.41219450
21	unsaturated fatty acid biosynthetic process (GO:0006636)	4.39127445
22	positive regulation of meiosis (GO:0045836)	4.36253366
23	reproduction (GO:0000003)	4.33371088
24	detection of molecule of bacterial origin (GO:0032490)	4.29171660
25	single fertilization (GO:0007338)	4.27455123
26	positive regulation of meiotic cell cycle (GO:0051446)	4.25598568
27	synaptonemal complex organization (GO:0070193)	4.25157731
28	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	4.21338101
29	regulation of female receptivity (GO:0045924)	4.21240315
30	glutathione metabolic process (GO:0006749)	4.16965044
31	negative regulation of Ras GTPase activity (GO:0034261)	4.11951304
32	synaptonemal complex assembly (GO:0007130)	4.08463041
33	gonadal mesoderm development (GO:0007506)	3.99139344
34	positive regulation of humoral immune response (GO:0002922)	3.93539939
35	meiosis I (GO:0007127)	3.91997991
36	cysteine metabolic process (GO:0006534)	3.76753892
37	protein kinase C signaling (GO:0070528)	3.73366672
38	regulation of female gonad development (GO:2000194)	3.71841631
39	acrosome reaction (GO:0007340)	3.67719864
40	regulation of uterine smooth muscle contraction (GO:0070472)	3.66637114
41	drinking behavior (GO:0042756)	3.66571110
42	protein K48-linked deubiquitination (GO:0071108)	3.64575789
43	male meiosis (GO:0007140)	3.63661015
44	aggressive behavior (GO:0002118)	3.61463437
45	binding of sperm to zona pellucida (GO:0007339)	3.53968181
46	female mating behavior (GO:0060180)	3.51864511
47	negative regulation of digestive system process (GO:0060457)	3.38606307
48	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.35688256
49	glycine transport (GO:0015816)	3.33402297
50	positive regulation by symbiont of host defense response (GO:0052509)	3.28588670
51	modulation by symbiont of host defense response (GO:0052031)	3.28588670
52	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	3.28588670
53	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	3.28588670
54	positive regulation by organism of defense response of other organism involved in symbiotic interact	3.28588670
55	modulation by symbiont of host immune response (GO:0052553)	3.28588670
56	maternal behavior (GO:0042711)	3.25033241
57	positive regulation of digestive system process (GO:0060456)	3.24821354
58	epithelial cilium movement (GO:0003351)	3.21357486
59	sleep (GO:0030431)	3.19804315
60	mitochondrion distribution (GO:0048311)	3.19135552
61	regulation of penile erection (GO:0060405)	3.13971132
62	fertilization (GO:0009566)	3.13814112
63	peristalsis (GO:0030432)	3.13228426
64	negative regulation of reproductive process (GO:2000242)	3.09402642
65	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.03836308
66	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.03836308
67	positive regulation of prostaglandin secretion (GO:0032308)	3.02979474
68	centriole replication (GO:0007099)	3.01751854
69	sperm-egg recognition (GO:0035036)	3.00313307
70	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	22.4180561
71	microglial cell activation (GO:0001774)	2.94434416
72	parental behavior (GO:0060746)	2.94124566
73	cilium or flagellum-dependent cell motility (GO:0001539)	2.86140422
74	protein K63-linked deubiquitination (GO:0070536)	2.86018954
75	icosanoid metabolic process (GO:0006690)	2.82555877
76	fatty acid derivative metabolic process (GO:1901568)	2.82555877
77	ventricular system development (GO:0021591)	2.81934663
78	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.80421269
79	regulation of neurotransmitter uptake (GO:0051580)	2.78369050
80	intestinal epithelial cell development (GO:0060576)	2.76457952
81	cilium movement (GO:0003341)	2.75464998
82	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.71978251
83	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.71607364
84	regulation of prostaglandin secretion (GO:0032306)	2.71102226
85	regulation of histone H3-K9 methylation (GO:0051570)	2.69196835
86	calcium ion-dependent exocytosis (GO:0017156)	2.64965540
87	response to acidic pH (GO:0010447)	2.63584082
88	protein K6-linked ubiquitination (GO:0085020)	2.62965522
89	cell-cell recognition (GO:0009988)	2.60278189
90	hyperosmotic salinity response (GO:0042538)	2.59611336
91	meiotic cell cycle (GO:0051321)	2.54545611
92	negative regulation of mRNA processing (GO:0050686)	2.54097338
93	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.53869102
94	regulation of meiosis (GO:0040020)	2.53404434
95	N-terminal protein amino acid modification (GO:0031365)	2.53139599
96	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.52000473
97	maturation of SSU-rRNA (GO:0030490)	2.50986488
98	chromosome organization involved in meiosis (GO:0070192)	2.50374875
99	regulation of retinoic acid receptor signaling pathway (GO:0048385)	18.6483311
100	histone H3-K9 demethylation (GO:0033169)	13.9235988

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.68432916
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.66577169
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.50554527
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.67903901
5	VDR_22108803_ChIP-Seq_LS180_Human	3.36073029
6	GBX2_23144817_ChIP-Seq_PC3_Human	3.18951629
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.07821108
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.89696054
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.62526937
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.52421459
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.44559354
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.40919137
13	IRF1_19129219_ChIP-ChIP_H3396_Human	2.24579819
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.19132380
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04882168
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.01400486
17	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.99413809
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.93403100
19	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.84953986
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.84836139
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.84543465
22	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.80694606
23	P300_19829295_ChIP-Seq_ESCs_Human	1.80270417
24	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.79991489
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77629801
26	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.77475129
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.75060257
28	STAT3_23295773_ChIP-Seq_U87_Human	1.70003603
29	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.67046708
30	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.63568867
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.61762538
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.60595379
33	TCF4_23295773_ChIP-Seq_U87_Human	1.59635498
34	AR_25329375_ChIP-Seq_VCAP_Human	1.55974509
35	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.55576299
36	RXR_22108803_ChIP-Seq_LS180_Human	1.50619000
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49414336
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48705666
39	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.47517644
40	GATA3_26560356_Chip-Seq_TH1_Human	1.46913999
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45920359
42	RUNX2_22187159_ChIP-Seq_PCA_Human	1.44766834
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42630638
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.42630638
45	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.42138045
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.40713609
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40291921
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39541998
49	SMRT_27268052_Chip-Seq_Bcells_Human	1.38073694
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36628369
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.34598761
52	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.33628011
53	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.30749237
54	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.29731139
55	NCOR_22424771_ChIP-Seq_293T_Human	1.28833728
56	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.28732089
57	GF1_26923725_Chip-Seq_HPCs_Mouse	1.27935073
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.27455191
59	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.27369646
60	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.26139090
61	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.26139090
62	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.26139090
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24402584
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.23442540
65	TP53_16413492_ChIP-PET_HCT116_Human	1.23057958
66	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.18993254
67	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.17730517
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17645902
69	ZNF274_21170338_ChIP-Seq_K562_Hela	1.17443715
70	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.16050832
71	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.14425125
72	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.13943991
73	CBP_21632823_ChIP-Seq_H3396_Human	1.12260354
74	AR_21572438_ChIP-Seq_LNCaP_Human	1.11656303
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.10070720
76	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09307441
77	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.09307441
78	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.08591362
79	TP63_23658742_ChIP-Seq_EP156T_Human	1.07388176
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07144629
81	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.06575346
82	MYC_18940864_ChIP-ChIP_HL60_Human	1.06440949
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05797242
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05622157
85	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.05121327
86	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.04536650
87	TP53_22573176_ChIP-Seq_HFKS_Human	1.04371777
88	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01514914
89	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00201257
90	CDX2_22108803_ChIP-Seq_LS180_Human	1.00088439
91	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98938441
92	ER_23166858_ChIP-Seq_MCF-7_Human	0.97167967
93	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.96549447
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96514689
95	VDR_24787735_ChIP-Seq_THP-1_Human	0.96143192
96	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95329086
97	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95329086
98	EWS_26573619_Chip-Seq_HEK293_Human	0.93896449
99	TBL1_22424771_ChIP-Seq_293T_Human	0.92181098
100	CJUN_26792858_Chip-Seq_BT549_Human	0.88678671

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	6.33785932
2	MP0006292_abnormal_olfactory_placode	4.72563161
3	MP0002163_abnormal_gland_morphology	4.42787574
4	MP0009379_abnormal_foot_pigmentation	3.65387683
5	MP0005220_abnormal_exocrine_pancreas	3.34568235
6	MP0003283_abnormal_digestive_organ	3.33011527
7	MP0005410_abnormal_fertilization	3.01840330
8	MP0003693_abnormal_embryo_hatching	2.90322939
9	MP0002160_abnormal_reproductive_system	2.83083544
10	MP0002736_abnormal_nociception_after	2.74863468
11	MP0005379_endocrine/exocrine_gland_phen	2.62608092
12	MP0000427_abnormal_hair_cycle	2.56568815
13	MP0000569_abnormal_digit_pigmentation	2.52776001
14	MP0001968_abnormal_touch/_nociception	2.52644338
15	MP0001502_abnormal_circadian_rhythm	2.33938510
16	MP0006276_abnormal_autonomic_nervous	2.30064126
17	MP0001986_abnormal_taste_sensitivity	2.29886214
18	MP0001929_abnormal_gametogenesis	2.25538755
19	MP0003950_abnormal_plasma_membrane	2.23078171
20	MP0003136_yellow_coat_color	2.20850667
21	MP0002277_abnormal_respiratory_mucosa	2.10500183
22	MP0000678_abnormal_parathyroid_gland	2.06030334
23	MP0003866_abnormal_defecation	1.98884817
24	MP0005360_urolithiasis	1.97122151
25	MP0005647_abnormal_sex_gland	1.92024312
26	MP0008877_abnormal_DNA_methylation	1.91230784
27	MP0002210_abnormal_sex_determination	1.87616234
28	MP0005389_reproductive_system_phenotype	1.80903737
29	MP0003699_abnormal_female_reproductive	1.77789877
30	MP0003195_calcinosis	1.73272571
31	MP0009840_abnormal_foam_cell	1.59971958
32	MP0003868_abnormal_feces_composition	1.52454627
33	MP0002751_abnormal_autonomic_nervous	1.50192224
34	MP0000653_abnormal_sex_gland	1.49454769
35	MP0001664_abnormal_digestion	1.45446747
36	MP0008995_early_reproductive_senescence	1.44719111
37	MP0008057_abnormal_DNA_replication	1.43948966
38	MP0000613_abnormal_salivary_gland	1.39861054
39	MP0002089_abnormal_postnatal_growth/wei	1.38544004
40	MP0000372_irregular_coat_pigmentation	1.38258987
41	MP0003698_abnormal_male_reproductive	1.37633202
42	MP0008058_abnormal_DNA_repair	1.37548400
43	MP0001666_abnormal_nutrient_absorption	1.36963333
44	MP0001119_abnormal_female_reproductive	1.35266921
45	MP0004381_abnormal_hair_follicle	1.34873969
46	MP0003718_maternal_effect	1.33489218
47	MP0002822_catalepsy	1.31880788
48	MP0000470_abnormal_stomach_morphology	1.22926038
49	MP0003959_abnormal_lean_body	1.22836073
50	MP0001145_abnormal_male_reproductive	1.19049480
51	MP0001440_abnormal_grooming_behavior	1.18892005
52	MP0003121_genomic_imprinting	1.18283889
53	MP0002127_abnormal_cardiovascular_syste	1.13755649
54	MP0005646_abnormal_pituitary_gland	1.13039405
55	MP0002161_abnormal_fertility/fecundity	1.12033496
56	MP0003890_abnormal_embryonic-extraembry	1.06918339
57	MP0002272_abnormal_nervous_system	1.04889958
58	MP0003119_abnormal_digestive_system	1.01626164
59	MP0005551_abnormal_eye_electrophysiolog	0.98804102
60	MP0010094_abnormal_chromosome_stability	0.98552795
61	MP0000049_abnormal_middle_ear	0.97681262
62	MP0004742_abnormal_vestibular_system	0.96519192
63	MP0002090_abnormal_vision	0.96079013
64	MP0010307_abnormal_tumor_latency	0.93534829
65	MP0004043_abnormal_pH_regulation	0.90506430
66	MP0002102_abnormal_ear_morphology	0.86455673
67	MP0005423_abnormal_somatic_nervous	0.85278575
68	MP0002067_abnormal_sensory_capabilities	0.84762170
69	MP0008260_abnormal_autophagy	0.84310807
70	MP0002095_abnormal_skin_pigmentation	0.82952414
71	MP0002735_abnormal_chemical_nociception	0.82442639
72	MP0003936_abnormal_reproductive_system	0.82250654
73	MP0005171_absent_coat_pigmentation	0.82215905
74	MP0004142_abnormal_muscle_tone	0.82077629
75	MP0005334_abnormal_fat_pad	0.81206781
76	MP0002229_neurodegeneration	0.80830131
77	MP0001944_abnormal_pancreas_morphology	0.79126768
78	MP0000631_abnormal_neuroendocrine_gland	0.77690894
79	MP0005187_abnormal_penis_morphology	0.76937573
80	MP0000534_abnormal_ureter_morphology	0.75728127
81	MP0006072_abnormal_retinal_apoptosis	0.71270755
82	MP0003077_abnormal_cell_cycle	0.70529744
83	MP0005499_abnormal_olfactory_system	0.68983336
84	MP0005394_taste/olfaction_phenotype	0.68983336
85	MP0000015_abnormal_ear_pigmentation	0.66075625
86	MP0000230_abnormal_systemic_arterial	0.65789129
87	MP0003828_pulmonary_edema	0.64935213
88	MP0008872_abnormal_physiological_respon	0.63096475
89	MP0003787_abnormal_imprinting	0.60450406
90	MP0001919_abnormal_reproductive_system	0.56491287
91	MP0003111_abnormal_nucleus_morphology	0.53069913
92	MP0003879_abnormal_hair_cell	0.52597640
93	MP0002734_abnormal_mechanical_nocicepti	0.51520448
94	MP0000647_abnormal_sebaceous_gland	0.50765205
95	MP0005174_abnormal_tail_pigmentation	0.50344424
96	MP0003656_abnormal_erythrocyte_physiolo	0.50162771
97	MP0005164_abnormal_response_to	0.49159424
98	MP0004957_abnormal_blastocyst_morpholog	0.48691422
99	MP0001501_abnormal_sleep_pattern	0.48455889
100	MP0005397_hematopoietic_system_phenotyp	0.47504413

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	5.78423730
2	Diastasis recti (HP:0001540)	5.65806812
3	Carpal bone hypoplasia (HP:0001498)	5.51929091
4	Vertebral arch anomaly (HP:0008438)	4.49800693
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.06607818
6	Absent/shortened dynein arms (HP:0200106)	4.06607818
7	Thoracolumbar scoliosis (HP:0002944)	4.01321926
8	Broad ribs (HP:0000885)	3.80501166
9	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.73481482
10	Abnormal respiratory motile cilium morphology (HP:0005938)	3.65732406
11	Abnormal respiratory epithelium morphology (HP:0012253)	3.65732406
12	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.65724966
13	Broad alveolar ridges (HP:0000187)	3.57701717
14	J-shaped sella turcica (HP:0002680)	3.55606447
15	Congenital sensorineural hearing impairment (HP:0008527)	3.50403429
16	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.47152206
17	Male infertility (HP:0003251)	3.36388020
18	Short tibia (HP:0005736)	3.31808857
19	Median cleft lip (HP:0000161)	3.27194100
20	Abnormal ciliary motility (HP:0012262)	3.24190722
21	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.13347268
22	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.13347268
23	Metaphyseal dysplasia (HP:0100255)	3.13005145
24	Abnormal auditory evoked potentials (HP:0006958)	3.08975222
25	Recurrent bronchitis (HP:0002837)	3.08877895
26	Flat acetabular roof (HP:0003180)	3.03996915
27	Thickened calvaria (HP:0002684)	2.93921475
28	Microglossia (HP:0000171)	2.92869160
29	Atonic seizures (HP:0010819)	2.89231712
30	Nonprogressive disorder (HP:0003680)	2.82737706
31	Hypoplasia of the fovea (HP:0007750)	2.82006689
32	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.82006689
33	Fair hair (HP:0002286)	2.79982669
34	Flared iliac wings (HP:0002869)	2.69949290
35	Chronic sinusitis (HP:0011109)	2.69466583
36	Abnormality of the corticospinal tract (HP:0002492)	2.68772067
37	Abnormal respiratory motile cilium physiology (HP:0012261)	2.64930767
38	Abnormality of the lumbar spine (HP:0100712)	2.64415033
39	Tetraparesis (HP:0002273)	2.60686497
40	Abnormality of the nasal septum (HP:0000419)	2.57880463
41	Abnormality of the alveolar ridges (HP:0006477)	2.52965386
42	Infertility (HP:0000789)	2.51709161
43	Abnormality of liposaccharide metabolism (HP:0010968)	2.51178109
44	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.51178109
45	Abnormality of glycolipid metabolism (HP:0010969)	2.51178109
46	Bronchitis (HP:0012387)	2.49978532
47	Tongue fasciculations (HP:0001308)	2.44455660
48	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.43859251
49	Cranial hyperostosis (HP:0004437)	2.42674675
50	Aplasia/Hypoplasia of the macula (HP:0008059)	2.41346433
51	Craniofacial hyperostosis (HP:0004493)	2.39142853
52	Oligodactyly (hands) (HP:0001180)	2.38918535
53	Abnormality of the thoracic spine (HP:0100711)	2.38735979
54	Palpebral edema (HP:0100540)	2.37511084
55	Abnormal number of incisors (HP:0011064)	2.35899973
56	Tetany (HP:0001281)	2.35793602
57	Facial cleft (HP:0002006)	2.35099932
58	Submucous cleft hard palate (HP:0000176)	2.34681023
59	Beaking of vertebral bodies (HP:0004568)	2.34272160
60	Hypophosphatemic rickets (HP:0004912)	2.28259788
61	Chronic otitis media (HP:0000389)	2.27959166
62	Anhidrosis (HP:0000970)	2.26926722
63	Muscle fibrillation (HP:0010546)	2.26744014
64	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.25400289
65	Aplasia/Hypoplasia of the scapulae (HP:0006713)	2.24974585
66	Hypoplastic scapulae (HP:0000882)	2.24974585
67	Adrenal hypoplasia (HP:0000835)	2.24726392
68	Rhinitis (HP:0012384)	2.23791725
69	Impulsivity (HP:0100710)	2.22895090
70	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21729082
71	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.18960803
72	Hyperphosphatemia (HP:0002905)	2.17368124
73	Abnormality of the fovea (HP:0000493)	2.15961195
74	Clumsiness (HP:0002312)	2.11981601
75	Generalized hypopigmentation of hair (HP:0011358)	2.11297113
76	Pancreatic fibrosis (HP:0100732)	2.11095914
77	Microretrognathia (HP:0000308)	2.09512345
78	Short chin (HP:0000331)	2.08101730
79	Short ribs (HP:0000773)	2.08016821
80	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.07773730
81	Osteomalacia (HP:0002749)	2.07028395
82	Bony spicule pigmentary retinopathy (HP:0007737)	2.04861486
83	Thoracic kyphosis (HP:0002942)	2.01066046
84	Aortic regurgitation (HP:0001659)	1.98548671
85	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.97456815
86	Death in childhood (HP:0003819)	1.97240291
87	Gaze-evoked nystagmus (HP:0000640)	1.95757683
88	Spinal muscular atrophy (HP:0007269)	1.94839163
89	Autoimmune thrombocytopenia (HP:0001973)	1.90289150
90	Corneal dystrophy (HP:0001131)	1.89600399
91	Abnormality of the acetabulum (HP:0003170)	1.89538584
92	Spontaneous hematomas (HP:0007420)	1.88831316
93	Deformed sella turcica (HP:0002681)	1.88650792
94	Attenuation of retinal blood vessels (HP:0007843)	1.86176272
95	Spontaneous abortion (HP:0005268)	1.85070328
96	Anomalous pulmonary venous return (HP:0010772)	1.84004524
97	Wide intermamillary distance (HP:0006610)	1.81249503
98	Abnormality of abdominal situs (HP:0011620)	1.79845272
99	Abdominal situs inversus (HP:0003363)	1.79845272
100	Constricted visual fields (HP:0001133)	1.78548758

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.75476395
2	INSRR	4.50751247
3	TNIK	3.57018851
4	PLK4	2.88439353
5	CDK19	2.69214972
6	TAOK3	2.65876312
7	MAP2K3	2.62200127
8	CDK12	2.47560078
9	BLK	2.22807460
10	FRK	2.04415429
11	WNK1	2.00060872
12	PDK2	1.97817884
13	IRAK4	1.95384246
14	SGK2	1.90117803
15	LATS2	1.88459096
16	ACVR1B	1.83949712
17	MAP3K3	1.79349522
18	ICK	1.55861243
19	TLK1	1.55752942
20	PIK3CG	1.54789267
21	TEC	1.49846539
22	STK38L	1.49568433
23	NEK6	1.47114539
24	AURKA	1.44220526
25	NLK	1.40124033
26	PLK2	1.37537532
27	BMPR1B	1.37253129
28	MAP3K2	1.36848694
29	IRAK1	1.35819600
30	DYRK3	1.35629408
31	CAMKK2	1.35527914
32	LATS1	1.34539748
33	TESK2	1.24711059
34	IRAK2	1.24463501
35	VRK1	1.22625409
36	MELK	1.21779315
37	ZAK	1.21395315
38	SRPK1	1.18813314
39	STK39	1.18595699
40	GRK5	1.18162088
41	SGK494	1.12253458
42	SGK223	1.12253458
43	STK24	1.09251462
44	CAMK4	1.09199560
45	PIM1	1.05582654
46	MAP3K5	1.04844394
47	GRK7	0.99419207
48	STK4	0.96703740
49	IKBKE	0.93891210
50	TRIM28	0.89624806
51	SGK3	0.89258929
52	BRD4	0.89015039
53	AURKB	0.86998000
54	NUAK1	0.79564579
55	TGFBR2	0.76739699
56	PTK2B	0.75519354
57	PLK1	0.75327247
58	OXSR1	0.73347953
59	NTRK3	0.72447708
60	CDC7	0.68717698
61	PDK1	0.67126858
62	STK3	0.66759092
63	RAF1	0.65728336
64	BRSK2	0.64609364
65	FGR	0.60533172
66	NEK9	0.60376397
67	CHEK2	0.58986767
68	PKN1	0.57371119
69	NTRK2	0.55325139
70	TXK	0.52269691
71	TIE1	0.49624687
72	BUB1	0.49431483
73	ADRBK1	0.48364756
74	SGK1	0.47912055
75	RET	0.47629858
76	PRKG1	0.46445686
77	EPHA4	0.45441505
78	PIK3CA	0.43770535
79	PDPK1	0.41222205
80	MARK3	0.40650573
81	TTK	0.40566431
82	LRRK2	0.39258794
83	CHEK1	0.39218045
84	PIM2	0.38882100
85	PLK3	0.36538035
86	WNK4	0.36300228
87	CDK7	0.35844564
88	MAPKAPK2	0.35200323
89	CASK	0.32994164
90	ADRBK2	0.32777119
91	YES1	0.29984712
92	GRK6	0.29513049
93	MOS	0.29305795
94	PRKD1	0.29274014
95	TBK1	0.28440646
96	RPS6KA5	0.27995878
97	CDK9	0.27402272
98	CAMK2A	0.27315455
99	SYK	0.26617845
100	PRKACA	0.26264733

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	5.58848550
2	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	4.73999006
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.61581728
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.33269161
5	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.18387375
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.48830589
7	Basal transcription factors_Homo sapiens_hsa03022	2.46978335
8	Taste transduction_Homo sapiens_hsa04742	2.33246558
9	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.92490165
10	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.91194924
11	Oocyte meiosis_Homo sapiens_hsa04114	1.71771692
12	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.63624137
13	Nicotine addiction_Homo sapiens_hsa05033	1.60318605
14	Mismatch repair_Homo sapiens_hsa03430	1.55824492
15	Bile secretion_Homo sapiens_hsa04976	1.55659190
16	mRNA surveillance pathway_Homo sapiens_hsa03015	1.49639214
17	Olfactory transduction_Homo sapiens_hsa04740	1.49598283
18	Ribosome_Homo sapiens_hsa03010	1.49067113
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.24158065
20	Serotonergic synapse_Homo sapiens_hsa04726	1.15949695
21	Amphetamine addiction_Homo sapiens_hsa05031	1.12408872
22	Morphine addiction_Homo sapiens_hsa05032	1.11829413
23	Homologous recombination_Homo sapiens_hsa03440	1.08290933
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08044164
25	Regulation of autophagy_Homo sapiens_hsa04140	1.07916606
26	Phototransduction_Homo sapiens_hsa04744	1.02182648
27	GABAergic synapse_Homo sapiens_hsa04727	1.01286220
28	Insulin secretion_Homo sapiens_hsa04911	1.00578991
29	RNA transport_Homo sapiens_hsa03013	1.00548874
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.93250065
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92686646
32	Alcoholism_Homo sapiens_hsa05034	0.91860317
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90462316
34	Linoleic acid metabolism_Homo sapiens_hsa00591	0.87991522
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84466007
36	RNA polymerase_Homo sapiens_hsa03020	0.82921813
37	cAMP signaling pathway_Homo sapiens_hsa04024	0.78098929
38	Cell cycle_Homo sapiens_hsa04110	0.77839917
39	Cocaine addiction_Homo sapiens_hsa05030	0.75953501
40	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.74695389
41	Calcium signaling pathway_Homo sapiens_hsa04020	0.74126289
42	Viral carcinogenesis_Homo sapiens_hsa05203	0.70674213
43	Cholinergic synapse_Homo sapiens_hsa04725	0.70360320
44	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.70173866
45	p53 signaling pathway_Homo sapiens_hsa04115	0.70163635
46	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.69205252
47	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.68992372
48	Retinol metabolism_Homo sapiens_hsa00830	0.63435186
49	Renin secretion_Homo sapiens_hsa04924	0.61358931
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60591027
51	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.59848174
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58370303
53	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.58165250
54	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.58147105
55	Circadian rhythm_Homo sapiens_hsa04710	0.57588793
56	Leishmaniasis_Homo sapiens_hsa05140	0.56983704
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.55334215
58	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.55233371
59	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53364894
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.52099420
61	Herpes simplex infection_Homo sapiens_hsa05168	0.52018598
62	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.51822505
63	RNA degradation_Homo sapiens_hsa03018	0.51447558
64	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.50640595
65	Gap junction_Homo sapiens_hsa04540	0.50495545
66	ABC transporters_Homo sapiens_hsa02010	0.50491169
67	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.50165738
68	MAPK signaling pathway_Homo sapiens_hsa04010	0.48169753
69	Wnt signaling pathway_Homo sapiens_hsa04310	0.48089734
70	Toxoplasmosis_Homo sapiens_hsa05145	0.47633142
71	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.47488685
72	Sulfur metabolism_Homo sapiens_hsa00920	0.46857111
73	Legionellosis_Homo sapiens_hsa05134	0.46642947
74	Spliceosome_Homo sapiens_hsa03040	0.46488140
75	Tuberculosis_Homo sapiens_hsa05152	0.45359963
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45289852
77	GnRH signaling pathway_Homo sapiens_hsa04912	0.44258905
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.42212880
79	Chemokine signaling pathway_Homo sapiens_hsa04062	0.42088843
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40594504
81	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.39545908
82	Long-term potentiation_Homo sapiens_hsa04720	0.39371395
83	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.39202757
84	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.38979373
85	Salivary secretion_Homo sapiens_hsa04970	0.38778833
86	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.38026445
87	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.38011688
88	Circadian entrainment_Homo sapiens_hsa04713	0.37741955
89	Prostate cancer_Homo sapiens_hsa05215	0.37499046
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.37088058
91	Influenza A_Homo sapiens_hsa05164	0.36100564
92	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.35788967
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.34947035
94	Pancreatic secretion_Homo sapiens_hsa04972	0.32125110
95	Prolactin signaling pathway_Homo sapiens_hsa04917	0.32048187
96	Osteoclast differentiation_Homo sapiens_hsa04380	0.31664237
97	FoxO signaling pathway_Homo sapiens_hsa04068	0.30974005
98	Malaria_Homo sapiens_hsa05144	0.30921731
99	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.28962284
100	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28733094

TRIM43CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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