TRIM44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.68834428
2locomotory exploration behavior (GO:0035641)5.61472607
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.46992072
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.10876475
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.91792756
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.86985404
7layer formation in cerebral cortex (GO:0021819)4.59687801
8glutamate secretion (GO:0014047)4.59301510
9vocalization behavior (GO:0071625)4.56107229
10synaptic vesicle exocytosis (GO:0016079)4.52023136
11regulation of synaptic vesicle exocytosis (GO:2000300)4.50501220
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.38659058
13regulation of glutamate receptor signaling pathway (GO:1900449)4.22893063
14exploration behavior (GO:0035640)4.10822966
15neurotransmitter secretion (GO:0007269)3.95463871
16dendritic spine morphogenesis (GO:0060997)3.89644237
17regulation of synaptic vesicle transport (GO:1902803)3.87082880
18proline transport (GO:0015824)3.78855751
19glucocorticoid receptor signaling pathway (GO:0042921)3.78119972
20sodium ion export (GO:0071436)3.75178453
21protein localization to synapse (GO:0035418)3.74416422
22regulation of NFAT protein import into nucleus (GO:0051532)3.73475798
23regulation of neuronal synaptic plasticity (GO:0048168)3.72022132
24regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69966093
25regulation of synapse structural plasticity (GO:0051823)3.67644932
26cellular potassium ion homeostasis (GO:0030007)3.67300542
27activation of protein kinase A activity (GO:0034199)3.66814217
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.58309199
29regulation of nucleobase-containing compound transport (GO:0032239)3.48277193
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.41116891
31dendrite morphogenesis (GO:0048813)3.39987364
32establishment of nucleus localization (GO:0040023)3.37579681
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.36923862
34regulation of RNA export from nucleus (GO:0046831)3.34164228
35neuron cell-cell adhesion (GO:0007158)3.31149789
36cerebellar Purkinje cell differentiation (GO:0021702)3.28498324
37regulation of ARF protein signal transduction (GO:0032012)3.28493306
38long-term memory (GO:0007616)3.26140446
39neurotransmitter-gated ion channel clustering (GO:0072578)3.25510400
40neuromuscular process controlling balance (GO:0050885)3.24994723
41synaptic transmission, glutamatergic (GO:0035249)3.23382183
42innervation (GO:0060384)3.21986612
43cell communication by electrical coupling (GO:0010644)3.20295364
44regulation of clathrin-mediated endocytosis (GO:2000369)3.19164947
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19143573
46gamma-aminobutyric acid transport (GO:0015812)3.15673329
47nuclear pore complex assembly (GO:0051292)3.15259195
48regulation of dendritic spine morphogenesis (GO:0061001)3.12313268
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12303159
50positive regulation of synapse maturation (GO:0090129)3.12273201
51glutamate receptor signaling pathway (GO:0007215)3.10938166
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.10676368
53vesicle transport along microtubule (GO:0047496)3.10454782
54axonal fasciculation (GO:0007413)3.10010734
55histone H3-K9 demethylation (GO:0033169)3.09110312
56neuron recognition (GO:0008038)3.06168062
57positive regulation of membrane potential (GO:0045838)3.05860940
58neurotransmitter transport (GO:0006836)3.03130065
59neuron-neuron synaptic transmission (GO:0007270)3.03114854
60neuronal action potential propagation (GO:0019227)3.01847898
61regulation of postsynaptic membrane potential (GO:0060078)2.99048502
62negative regulation of dendrite morphogenesis (GO:0050774)2.97721172
63corticosteroid receptor signaling pathway (GO:0031958)2.93896965
64regulation of synaptic plasticity (GO:0048167)2.92976677
65synaptic vesicle endocytosis (GO:0048488)2.88347917
66auditory behavior (GO:0031223)2.88095461
67prepulse inhibition (GO:0060134)2.87284343
68positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.86055044
69camera-type eye morphogenesis (GO:0048593)2.85154969
70regulation of neurotransmitter secretion (GO:0046928)2.84686675
71suckling behavior (GO:0001967)2.81845522
72cytoplasmic mRNA processing body assembly (GO:0033962)2.81517691
73regulation of neurotransmitter levels (GO:0001505)2.81194505
74long-term synaptic potentiation (GO:0060291)2.80853833
75cytoskeletal anchoring at plasma membrane (GO:0007016)2.80560833
76glycine transport (GO:0015816)2.79836593
77dendritic spine organization (GO:0097061)2.77995184
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77828562
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.76189584
80protein retention in ER lumen (GO:0006621)2.75264559
81clathrin coat assembly (GO:0048268)2.74969521
82maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70639843
83cerebellar granule cell differentiation (GO:0021707)2.69842903
84organelle transport along microtubule (GO:0072384)2.69785895
85potassium ion import (GO:0010107)2.69243490
86cerebellar Purkinje cell layer development (GO:0021680)2.68369734
87mating behavior (GO:0007617)2.67868667
88cellular sodium ion homeostasis (GO:0006883)2.67569465
89membrane depolarization during action potential (GO:0086010)2.66963749
90positive regulation of dendritic spine morphogenesis (GO:0061003)2.66365906
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.66283910
92positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.66156493
93response to auditory stimulus (GO:0010996)2.65613773
94chemosensory behavior (GO:0007635)2.65383877
95positive regulation of synaptic transmission, GABAergic (GO:0032230)2.64296610
96peptidyl-threonine phosphorylation (GO:0018107)2.63511505
97cell migration in hindbrain (GO:0021535)2.63284581
98positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.63062158
99regulation of neurotransmitter transport (GO:0051588)2.61718669
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61646554
101activation of Rac GTPase activity (GO:0032863)2.61282366
102negative regulation of fatty acid transport (GO:2000192)2.60650542
103neuromuscular process (GO:0050905)2.59468608
104peptidyl-threonine modification (GO:0018210)2.59429637
105social behavior (GO:0035176)2.58666052
106intraspecies interaction between organisms (GO:0051703)2.58666052
107synapse organization (GO:0050808)2.58535842
108membrane repolarization (GO:0086009)2.57450119
109regulation of histone H3-K27 methylation (GO:0061085)2.56654786
110nerve growth factor signaling pathway (GO:0038180)2.56017292
111positive regulation of neurotransmitter transport (GO:0051590)2.55559493
112transmission of nerve impulse (GO:0019226)2.55105220
113membrane hyperpolarization (GO:0060081)2.55103415
114membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.54170307
115behavioral defense response (GO:0002209)2.54145409
116behavioral fear response (GO:0001662)2.54145409
117membrane depolarization (GO:0051899)2.53491853
118negative regulation of sodium ion transport (GO:0010766)2.53458623
119insulin-like growth factor receptor signaling pathway (GO:0048009)2.49588888
120histone H3-K36 demethylation (GO:0070544)2.49085671
121embryonic retina morphogenesis in camera-type eye (GO:0060059)2.46393404
122cortical actin cytoskeleton organization (GO:0030866)2.45552192
123response to parathyroid hormone (GO:0071107)2.44733461
124regulation of glucose import in response to insulin stimulus (GO:2001273)2.44219338
125cell-substrate adherens junction assembly (GO:0007045)2.43122647
126focal adhesion assembly (GO:0048041)2.43122647
127positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.42805399
128nucleus localization (GO:0051647)2.42075310
129neural tube development (GO:0021915)2.37990582
130peripheral nervous system axon ensheathment (GO:0032292)2.37318707
131myelination in peripheral nervous system (GO:0022011)2.37318707
132cellular response to catecholamine stimulus (GO:0071870)2.37051520
133cellular response to monoamine stimulus (GO:0071868)2.37051520
134histone H3-K4 trimethylation (GO:0080182)2.36211923
135mitotic sister chromatid cohesion (GO:0007064)2.35705627
136adherens junction assembly (GO:0034333)2.34818747
137regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.34666749
138nuclear pore organization (GO:0006999)2.32981447
139stress granule assembly (GO:0034063)2.32732659
140regulation of early endosome to late endosome transport (GO:2000641)2.32116891
141metanephric mesenchyme development (GO:0072075)2.31900197
142regulation of Rac protein signal transduction (GO:0035020)2.29603013
143response to epidermal growth factor (GO:0070849)2.29420057
144regulation of ARF GTPase activity (GO:0032312)2.28242593
145establishment of spindle orientation (GO:0051294)2.27664957
146neuronal ion channel clustering (GO:0045161)2.24757908
147hippo signaling (GO:0035329)2.23275363
148SMAD protein complex assembly (GO:0007183)2.22570542
149eye morphogenesis (GO:0048592)2.22298894
150cortical cytoskeleton organization (GO:0030865)2.21319940
151semaphorin-plexin signaling pathway (GO:0071526)2.20928278
152negative regulation of erythrocyte differentiation (GO:0045647)2.20252555
153axon extension (GO:0048675)2.17253468
154cell-substrate junction assembly (GO:0007044)2.15762109
155apical protein localization (GO:0045176)2.15199571
156kidney mesenchyme development (GO:0072074)2.14693433
157cell-cell junction maintenance (GO:0045217)2.14036585
158protein localization to endosome (GO:0036010)2.13924377
159body morphogenesis (GO:0010171)2.13414214
160cellular response to prostaglandin stimulus (GO:0071379)2.11857137
161axon ensheathment in central nervous system (GO:0032291)2.11769158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.89735001
2GBX2_23144817_ChIP-Seq_PC3_Human2.67968127
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65091419
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60700196
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57621443
6DROSHA_22980978_ChIP-Seq_HELA_Human2.49131138
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48168417
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48168417
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45240166
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.41782916
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.39852599
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24311602
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23314123
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23185669
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21430664
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14314378
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14100983
18* REST_21632747_ChIP-Seq_MESCs_Mouse2.13852974
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.10475807
20* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10010180
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01241891
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.98066877
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97397274
24AR_21572438_ChIP-Seq_LNCaP_Human1.87150756
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.86941347
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86654417
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.85501073
28* REST_18959480_ChIP-ChIP_MESCs_Mouse1.71684736
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69811897
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64248524
31P300_27058665_Chip-Seq_ZR-75-30cells_Human1.63430262
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60764755
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60737932
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59190238
35CLOCK_20551151_ChIP-Seq_293T_Human1.57746611
36* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56721056
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.56248640
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.56154304
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55220229
40SMAD4_21799915_ChIP-Seq_A2780_Human1.54161587
41MYC_22102868_ChIP-Seq_BL_Human1.53200460
42TCF7_22412390_ChIP-Seq_EML_Mouse1.52487709
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51933417
44ZNF274_21170338_ChIP-Seq_K562_Hela1.50531616
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.48321539
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48287946
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47609569
48KDM2B_26808549_Chip-Seq_DND41_Human1.46786262
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45343393
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43145314
51DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42473874
52KDM2B_26808549_Chip-Seq_K562_Human1.41094369
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.40251875
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38309979
55AR_19668381_ChIP-Seq_PC3_Human1.38251159
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37357436
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36646601
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36402717
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.36232739
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36102836
61* FOXA2_19822575_ChIP-Seq_HepG2_Human1.35847009
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35290486
63* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34805543
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34214480
65* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33491198
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32508430
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31120933
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30769988
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.30143161
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.28125674
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.26902624
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25924587
73AHR_22903824_ChIP-Seq_MCF-7_Human1.25183431
74TP53_16413492_ChIP-PET_HCT116_Human1.24891615
75* STAT3_23295773_ChIP-Seq_U87_Human1.24791549
76* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23264852
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22505534
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22001399
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.21173230
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.20908564
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20577242
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19674027
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19073444
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18791277
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18196350
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17638040
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.17291281
88RACK7_27058665_Chip-Seq_MCF-7_Human1.16517930
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16107963
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15445523
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.14210224
92AR_25329375_ChIP-Seq_VCAP_Human1.13425576
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.12731736
94TBX20_22080862_ChIP-Seq_HEART_Mouse1.12731736
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11739587
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.09690020
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08821720
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08819253
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08232433
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07942680
101RXR_22108803_ChIP-Seq_LS180_Human1.07517032
102CREB1_26743006_Chip-Seq_LNCaP_Human1.07358326
103P300_19829295_ChIP-Seq_ESCs_Human1.07050651
104ELK3_25401928_ChIP-Seq_HUVEC_Human1.06120396
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05684815
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04844662
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04344555
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04295702
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03976775
110SMAD4_21741376_ChIP-Seq_HESCs_Human1.03961990
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03952231
112* TCF4_23295773_ChIP-Seq_U87_Human1.03132958
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02448637
114* EP300_21415370_ChIP-Seq_HL-1_Mouse1.02043185
115LXR_22292898_ChIP-Seq_THP-1_Human1.01530305
116TET1_21490601_ChIP-Seq_MESCs_Mouse1.01496571
117RUNX1_27514584_Chip-Seq_MCF-7_Human1.01108453
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00967068
119* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00767011
120TAF15_26573619_Chip-Seq_HEK293_Human1.00509546
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00201163
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.99229918
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98877723
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98208682
125* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97487770
126PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97373439
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.97086324
128OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97035053
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96941314
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.96208052
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95397593
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95118895
133KDM2B_26808549_Chip-Seq_JURKAT_Human0.94994923
134* TP53_23651856_ChIP-Seq_MEFs_Mouse0.94934327
135VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94457703
136FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93726948
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90163952
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89876385
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89553230
140NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89430471
141TCF4_18268006_ChIP-ChIP_LS174T_Human0.88341468
142CBX2_27304074_Chip-Seq_ESCs_Mouse0.86997565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.39373790
2MP0003635_abnormal_synaptic_transmissio3.86916841
3MP0004270_analgesia3.37514174
4MP0003880_abnormal_central_pattern3.20012725
5MP0005409_darkened_coat_color3.07371033
6MP0002063_abnormal_learning/memory/cond3.06120657
7MP0009780_abnormal_chondrocyte_physiolo2.93910344
8MP0009745_abnormal_behavioral_response2.81979568
9MP0002064_seizures2.63985328
10MP0009046_muscle_twitch2.51493258
11MP0002572_abnormal_emotion/affect_behav2.36181826
12MP0001968_abnormal_touch/_nociception2.34811239
13MP0000569_abnormal_digit_pigmentation2.28987362
14MP0005423_abnormal_somatic_nervous2.27502655
15MP0008438_abnormal_cutaneous_collagen2.24777397
16MP0002909_abnormal_adrenal_gland2.23933004
17MP0002734_abnormal_mechanical_nocicepti2.19063438
18MP0001486_abnormal_startle_reflex2.17784239
19MP0001348_abnormal_lacrimal_gland2.13875199
20MP0003122_maternal_imprinting1.97867104
21MP0002877_abnormal_melanocyte_morpholog1.97406944
22MP0003787_abnormal_imprinting1.96015851
23MP0002272_abnormal_nervous_system1.95302422
24MP0002822_catalepsy1.90626822
25MP0003091_abnormal_cell_migration1.86308848
26MP0004858_abnormal_nervous_system1.84901571
27MP0008569_lethality_at_weaning1.84131587
28MP0004811_abnormal_neuron_physiology1.79024575
29MP0000778_abnormal_nervous_system1.73607982
30MP0004885_abnormal_endolymph1.73581192
31MP0001501_abnormal_sleep_pattern1.73463523
32MP0008057_abnormal_DNA_replication1.71778710
33MP0002184_abnormal_innervation1.66082645
34MP0005187_abnormal_penis_morphology1.63413694
35MP0008961_abnormal_basal_metabolism1.62872451
36MP0010234_abnormal_vibrissa_follicle1.61823278
37MP0002067_abnormal_sensory_capabilities1.61288290
38MP0002557_abnormal_social/conspecific_i1.57626479
39MP0002733_abnormal_thermal_nociception1.53535407
40MP0000955_abnormal_spinal_cord1.50597982
41MP0005386_behavior/neurological_phenoty1.49075979
42MP0004924_abnormal_behavior1.49075979
43MP0001440_abnormal_grooming_behavior1.47737956
44MP0004272_abnormal_basement_membrane1.47515872
45MP0003300_gastrointestinal_ulcer1.46895697
46MP0005646_abnormal_pituitary_gland1.46224487
47MP0002736_abnormal_nociception_after1.45904005
48MP0003115_abnormal_respiratory_system1.45069792
49MP0001970_abnormal_pain_threshold1.43791591
50MP0003566_abnormal_cell_adhesion1.40566403
51MP0003329_amyloid_beta_deposits1.39498821
52MP0002735_abnormal_chemical_nociception1.38000563
53MP0001299_abnormal_eye_distance/1.35226017
54MP0002882_abnormal_neuron_morphology1.35121067
55MP0003283_abnormal_digestive_organ1.34229839
56MP0003633_abnormal_nervous_system1.28849856
57MP0004233_abnormal_muscle_weight1.27108123
58MP0004185_abnormal_adipocyte_glucose1.23284959
59MP0002066_abnormal_motor_capabilities/c1.21455523
60MP0005623_abnormal_meninges_morphology1.19259165
61MP0000733_abnormal_muscle_development1.18653266
62MP0002152_abnormal_brain_morphology1.18554641
63MP0003879_abnormal_hair_cell1.17423018
64MP0003868_abnormal_feces_composition1.15369292
65MP0003950_abnormal_plasma_membrane1.15226697
66MP0000013_abnormal_adipose_tissue1.14516064
67MP0001502_abnormal_circadian_rhythm1.13095687
68MP0003890_abnormal_embryonic-extraembry1.11296501
69MP0001177_atelectasis1.11183462
70MP0010352_gastrointestinal_tract_polyps1.11154185
71MP0005503_abnormal_tendon_morphology1.10001525
72MP0001984_abnormal_olfaction1.09448455
73MP0002009_preneoplasia1.08480900
74MP0002249_abnormal_larynx_morphology1.07163704
75MP0000462_abnormal_digestive_system1.06799871
76MP0005551_abnormal_eye_electrophysiolog1.05948905
77MP0003123_paternal_imprinting1.05308597
78MP0004808_abnormal_hematopoietic_stem1.05144684
79MP0000428_abnormal_craniofacial_morphol1.04623705
80MP0005257_abnormal_intraocular_pressure1.04397596
81MP0001958_emphysema1.03925372
82MP0005666_abnormal_adipose_tissue1.03781073
83MP0003631_nervous_system_phenotype1.03486008
84MP0003121_genomic_imprinting1.03237289
85MP0005645_abnormal_hypothalamus_physiol1.00985056
86MP0003943_abnormal_hepatobiliary_system1.00815680
87MP0002234_abnormal_pharynx_morphology1.00604273
88MP0010630_abnormal_cardiac_muscle0.98363391
89MP0000631_abnormal_neuroendocrine_gland0.97037643
90MP0005375_adipose_tissue_phenotype0.96999291
91MP0004130_abnormal_muscle_cell0.96194184
92MP0003959_abnormal_lean_body0.96094514
93MP0000534_abnormal_ureter_morphology0.95647598
94MP0000751_myopathy0.94046359
95MP0000537_abnormal_urethra_morphology0.91996328
96MP0002090_abnormal_vision0.91447093
97MP0001849_ear_inflammation0.90611638
98MP0005621_abnormal_cell_physiology0.90078153
99MP0004085_abnormal_heartbeat0.89710783
100MP0001346_abnormal_lacrimal_gland0.89658367
101MP0002069_abnormal_eating/drinking_beha0.88227353
102MP0003045_fibrosis0.88143646
103MP0005248_abnormal_Harderian_gland0.87668736
104MP0000003_abnormal_adipose_tissue0.86492839
105MP0000920_abnormal_myelination0.86004075
106MP0003690_abnormal_glial_cell0.85697258
107MP0002084_abnormal_developmental_patter0.82001557
108MP0000678_abnormal_parathyroid_gland0.80954412
109MP0002081_perinatal_lethality0.80527712
110MP0009672_abnormal_birth_weight0.79708964
111MP0006276_abnormal_autonomic_nervous0.79023084
112MP0003861_abnormal_nervous_system0.78104946
113MP0000747_muscle_weakness0.77861034
114MP0004145_abnormal_muscle_electrophysio0.77618708
115MP0003634_abnormal_glial_cell0.77527078
116MP0003183_abnormal_peptide_metabolism0.76786499
117MP0009703_decreased_birth_body0.76448562
118MP0004087_abnormal_muscle_fiber0.75618228
119MP0002114_abnormal_axial_skeleton0.75504946
120MP0002089_abnormal_postnatal_growth/wei0.75365211
121MP0003632_abnormal_nervous_system0.74442758
122MP0002229_neurodegeneration0.74242910
123MP0003705_abnormal_hypodermis_morpholog0.73662133
124MP0005167_abnormal_blood-brain_barrier0.72891519
125MP0002116_abnormal_craniofacial_bone0.72638286
126MP0004043_abnormal_pH_regulation0.70837447
127MP0004215_abnormal_myocardial_fiber0.68047338
128MP0001943_abnormal_respiration0.67647256
129MP0008874_decreased_physiological_sensi0.65991702
130MP0004484_altered_response_of0.64408182
131MP0005499_abnormal_olfactory_system0.64120387
132MP0005394_taste/olfaction_phenotype0.64120387
133MP0003385_abnormal_body_wall0.62690726
134MP0005535_abnormal_body_temperature0.62217767
135MP0002896_abnormal_bone_mineralization0.62194086
136MP0003942_abnormal_urinary_system0.61916415
137MP0010769_abnormal_survival0.59138437
138MP0002752_abnormal_somatic_nervous0.58652990
139MP0005076_abnormal_cell_differentiation0.58494895
140MP0003075_altered_response_to0.58377542
141MP0010770_preweaning_lethality0.57490174
142MP0002082_postnatal_lethality0.57490174
143MP0008872_abnormal_physiological_respon0.56624997

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.63098601
2Myokymia (HP:0002411)4.56374626
3Focal seizures (HP:0007359)4.11314462
4Visual hallucinations (HP:0002367)3.88556934
5Action tremor (HP:0002345)3.75632833
6Progressive cerebellar ataxia (HP:0002073)3.40860174
7Papilledema (HP:0001085)3.37951098
8Epileptic encephalopathy (HP:0200134)3.33048943
9Protrusio acetabuli (HP:0003179)3.25596901
10Genetic anticipation (HP:0003743)3.18984918
11Macroorchidism (HP:0000053)3.04245309
12Atonic seizures (HP:0010819)2.91589667
13Absence seizures (HP:0002121)2.90872575
14Impaired vibration sensation in the lower limbs (HP:0002166)2.83326386
15Febrile seizures (HP:0002373)2.80155349
16Urinary bladder sphincter dysfunction (HP:0002839)2.79677631
17Abnormality of the lower motor neuron (HP:0002366)2.75979533
18Premature rupture of membranes (HP:0001788)2.74147720
19Depression (HP:0000716)2.73281737
20Poor eye contact (HP:0000817)2.71149418
21Dysmetric saccades (HP:0000641)2.70579219
22Broad-based gait (HP:0002136)2.69253457
23Termporal pattern (HP:0011008)2.67655787
24Insidious onset (HP:0003587)2.67655787
25Arterial tortuosity (HP:0005116)2.66423352
26Impaired social interactions (HP:0000735)2.66113656
27Abnormal social behavior (HP:0012433)2.66113656
28Truncal ataxia (HP:0002078)2.65580384
29Insomnia (HP:0100785)2.56928820
30Ankle clonus (HP:0011448)2.56790337
31Hyperacusis (HP:0010780)2.55449469
32Excessive salivation (HP:0003781)2.54423146
33Drooling (HP:0002307)2.54423146
34Dysdiadochokinesis (HP:0002075)2.54133716
35Generalized tonic-clonic seizures (HP:0002069)2.52507179
36Supranuclear gaze palsy (HP:0000605)2.51436911
37Vertebral arch anomaly (HP:0008438)2.48064388
38Pointed chin (HP:0000307)2.43830126
39Vascular tortuosity (HP:0004948)2.43790132
40Dialeptic seizures (HP:0011146)2.43522529
41Postural instability (HP:0002172)2.42922746
42Elfin facies (HP:0004428)2.42435331
43Gaze-evoked nystagmus (HP:0000640)2.41897705
44Heterotopia (HP:0002282)2.40984134
45Impaired smooth pursuit (HP:0007772)2.40735308
46Urinary urgency (HP:0000012)2.37392311
47Ankyloglossia (HP:0010296)2.33415254
48Megalencephaly (HP:0001355)2.29284914
49Aortic aneurysm (HP:0004942)2.28442058
50Asymmetry of the thorax (HP:0001555)2.27079007
51Agitation (HP:0000713)2.25804948
52Cerebral aneurysm (HP:0004944)2.25010483
53Hemiplegia (HP:0002301)2.20759504
54Aqueductal stenosis (HP:0002410)2.17947208
55Anxiety (HP:0000739)2.17942590
56Abnormality of ocular smooth pursuit (HP:0000617)2.17618267
57Dysmetria (HP:0001310)2.15879348
58Torticollis (HP:0000473)2.14261106
59Intention tremor (HP:0002080)2.14026223
60Overriding aorta (HP:0002623)2.11939178
61Disproportionate tall stature (HP:0001519)2.11115996
62Mutism (HP:0002300)2.10944264
63Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.10902009
64Overgrowth (HP:0001548)2.10002524
65Stereotypic behavior (HP:0000733)2.09904968
66Hyperventilation (HP:0002883)2.08241240
67Obsessive-compulsive behavior (HP:0000722)2.08218740
68Abnormal eating behavior (HP:0100738)2.08164866
69Aortic dissection (HP:0002647)2.07326223
70Renovascular hypertension (HP:0100817)2.06863697
71Flat acetabular roof (HP:0003180)2.06128056
72Abnormality of the fingertips (HP:0001211)2.05738939
73Renal duplication (HP:0000075)2.05593945
74Relative macrocephaly (HP:0004482)2.05504655
75Scanning speech (HP:0002168)2.04150877
76Bladder diverticulum (HP:0000015)2.04023266
77Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03695460
78Mitral valve prolapse (HP:0001634)2.03183138
79Broad palm (HP:0001169)2.02592755
80Short nail (HP:0001799)2.00976743
81Neoplasm of the heart (HP:0100544)2.00200388
82Inappropriate behavior (HP:0000719)1.99715515
83Distal upper limb amyotrophy (HP:0007149)1.99402262
84Upper limb amyotrophy (HP:0009129)1.99402262
85Flat cornea (HP:0007720)1.98769792
86Amblyopia (HP:0000646)1.97302291
87Mitral regurgitation (HP:0001653)1.97069639
88Annular pancreas (HP:0001734)1.96783029
89Lower limb amyotrophy (HP:0007210)1.96588996
90Spastic gait (HP:0002064)1.96361511
91Enlarged penis (HP:0000040)1.94927221
92Epileptiform EEG discharges (HP:0011182)1.94084971
93Neurofibrillary tangles (HP:0002185)1.93494390
94EEG with generalized epileptiform discharges (HP:0011198)1.91648896
95Ventricular fibrillation (HP:0001663)1.88534580
96Broad face (HP:0000283)1.88235653
97Hypsarrhythmia (HP:0002521)1.87310406
98Dislocated radial head (HP:0003083)1.85716784
99Germ cell neoplasia (HP:0100728)1.85028060
100Postural tremor (HP:0002174)1.84470366
101Broad metatarsal (HP:0001783)1.84279612
102Shallow orbits (HP:0000586)1.84116189
103Lower limb asymmetry (HP:0100559)1.83551789
104Increased nuchal translucency (HP:0010880)1.83484852
105Papillary thyroid carcinoma (HP:0002895)1.83380296
106Focal dystonia (HP:0004373)1.82676176
107Impaired vibratory sensation (HP:0002495)1.82203960
108Rhizomelia (HP:0008905)1.81813692
109Resting tremor (HP:0002322)1.81504385
110Cerebral inclusion bodies (HP:0100314)1.81452552
111Buphthalmos (HP:0000557)1.81148250
112Ulnar bowing (HP:0003031)1.80986253
113Sacral dimple (HP:0000960)1.80181317
114Abnormality of the corticospinal tract (HP:0002492)1.79911870
115Central scotoma (HP:0000603)1.79624152
116Hammertoe (HP:0001765)1.78895225
117Bronchomalacia (HP:0002780)1.78669138
118Urethral obstruction (HP:0000796)1.78345133
119Long eyelashes (HP:0000527)1.77876351
120Mild short stature (HP:0003502)1.77875249
121Hypoventilation (HP:0002791)1.77378234
122Patellar dislocation (HP:0002999)1.77316318
123Bradykinesia (HP:0002067)1.77106016
124Lymphangioma (HP:0100764)1.76360961
125Narrow palate (HP:0000189)1.76330451
126Abnormality of oral frenula (HP:0000190)1.75991813
127Menstrual irregularities (HP:0000858)1.75574046
128Hepatoblastoma (HP:0002884)1.74976165
129Amyotrophic lateral sclerosis (HP:0007354)1.74029671
130Turricephaly (HP:0000262)1.73841129
131Wormian bones (HP:0002645)1.73200408
132Intellectual disability, profound (HP:0002187)1.73076059
133Spinal cord lesions (HP:0100561)1.71939886
134Syringomyelia (HP:0003396)1.71939886
135Absent speech (HP:0001344)1.71358596
136Lower limb muscle weakness (HP:0007340)1.71226295
137Distal lower limb amyotrophy (HP:0008944)1.70888428
138Bowel diverticulosis (HP:0005222)1.70855444
139Aneurysm (HP:0002617)1.70518244
140Hand muscle atrophy (HP:0009130)1.69857462
141Fragile skin (HP:0001030)1.69560018
142Missing ribs (HP:0000921)1.68919928
143Dilatation of the ascending aorta (HP:0005111)1.67005858
144Abnormality of the radial head (HP:0003995)1.66229115
145Abnormality of dentin (HP:0010299)1.65461362
146Short 4th metacarpal (HP:0010044)1.65315618
147Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65315618
148Abnormality of binocular vision (HP:0011514)1.65251796
149Diplopia (HP:0000651)1.65251796
150Bundle branch block (HP:0011710)1.64717612
151Obstructive sleep apnea (HP:0002870)1.64552116
152Subacute progressive viral hepatitis (HP:0006572)1.64109265
153Blue irides (HP:0000635)1.63368876
154Thin bony cortex (HP:0002753)1.63284155
155Craniofacial dystonia (HP:0012179)1.62952158
156Advanced eruption of teeth (HP:0006288)1.62619801
157Abnormality of the distal phalanx of the thumb (HP:0009617)1.61628203
158Attention deficit hyperactivity disorder (HP:0007018)1.61121862
159Bowel incontinence (HP:0002607)1.60298949
160Overlapping toe (HP:0001845)1.60047227
161Deep palmar crease (HP:0006191)1.58845487
162Joint laxity (HP:0001388)1.58225290
163Thick eyebrow (HP:0000574)1.58045913
164Volvulus (HP:0002580)1.57220291
165Arnold-Chiari malformation (HP:0002308)1.56924968
166Neonatal short-limb short stature (HP:0008921)1.56356979
167Truncal obesity (HP:0001956)1.55913097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.81291577
2MAP3K93.48058380
3CDK123.10818869
4EPHA43.04567332
5MARK12.99987625
6MAP3K42.82284275
7PRKD32.54616077
8MINK12.42015122
9DAPK22.26416802
10PAK62.21013321
11EEF2K2.16452591
12NTRK22.00459771
13KSR21.99117131
14CAMKK11.99015016
15MET1.77273478
16MAP2K41.74729232
17MAP2K71.73898158
18NTRK11.67490782
19KSR11.65596148
20CAMK1G1.63857755
21MAP3K21.58830808
22STK381.56655581
23RIPK11.56069577
24SIK21.53535531
25FGFR41.50160361
26MST1R1.40816619
27RET1.37561851
28LATS21.37361554
29CDK51.36445667
30TYRO31.32342517
31FGFR21.30785004
32MTOR1.29288901
33TRIB31.27595269
34PRKCH1.25360867
35TAOK11.25022567
36MAP3K101.21938005
37DAPK11.18108178
38PLK21.18095150
39SCYL21.16369882
40SGK31.13690902
41ALK1.12039659
42BRD41.09758144
43LATS11.09194571
44PDGFRA1.07420876
45CAMK1D1.05545616
46DMPK1.03295899
47CAMKK21.01788472
48SGK20.98963207
49STK110.97275705
50SGK2230.96257499
51SGK4940.96257499
52UHMK10.96139433
53MAPK130.94134301
54PKN20.93483205
55PAK30.93329475
56WNK10.91641420
57PNCK0.89556133
58SMG10.87412334
59PRKCG0.86843033
60CAMK10.84161282
61LMTK20.84014488
62PAK20.83135668
63MARK20.80963809
64CDC42BPA0.80311243
65PHKG20.78900951
66PHKG10.78900951
67BMPR20.77995949
68MAP3K120.76931128
69MAP3K70.75570453
70CSNK1G20.75562342
71BMX0.75355499
72NEK90.74724582
73TTN0.74429982
74RIPK40.74389498
75SGK10.73736296
76CDK190.72734148
77GRK50.71776198
78NEK10.71172102
79ERBB30.70300605
80AKT30.70174625
81PDK10.68742349
82MAP3K60.68725422
83FES0.68667521
84PRPF4B0.68452972
85DDR20.67208569
86NEK60.66489772
87PDGFRB0.65270984
88CDK180.65026685
89CDK140.64534907
90CDK150.64102869
91FER0.62967438
92PTK2B0.61925077
93FRK0.61754169
94RPS6KA30.60233278
95SIK10.59196107
96CAMK2A0.59145159
97PDPK10.59059980
98WNK30.57302398
99MAPK100.57158514
100NEK20.56634452
101PRKD20.55997236
102CAMK40.54809181
103FGFR10.53962062
104MAPK110.53483651
105PRKCZ0.53391296
106MAP3K130.53070584
107CDK11A0.53049332
108BRSK10.52273867
109DYRK1A0.51895662
110MAP2K10.51426584
111MAP3K10.50925055
112JAK10.50130088
113FYN0.49145993
114ERN10.49041605
115CDK60.48529919
116ICK0.48390777
117PTK60.48011521
118MELK0.46541306
119CAMK2B0.46457576
120RPS6KA20.46193370
121ERBB20.45576169
122WNK40.44292731
123RAF10.43460827
124RPS6KB20.43298571
125ROCK20.42858687
126CSNK1E0.42514910
127FGFR30.42402529
128GSK3B0.40715876
129OXSR10.39955448
130PTK20.39579588
131MAPK80.36889835
132HIPK20.36722027

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.56570175
2Synaptic vesicle cycle_Homo sapiens_hsa047212.41876871
3Long-term potentiation_Homo sapiens_hsa047202.32654960
4Circadian entrainment_Homo sapiens_hsa047132.32229991
5Olfactory transduction_Homo sapiens_hsa047402.24898101
6GABAergic synapse_Homo sapiens_hsa047272.21045088
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09669559
8Glutamatergic synapse_Homo sapiens_hsa047242.08450753
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03540811
10Nitrogen metabolism_Homo sapiens_hsa009102.02949119
11Amphetamine addiction_Homo sapiens_hsa050312.02033902
12Morphine addiction_Homo sapiens_hsa050321.98661778
13Dopaminergic synapse_Homo sapiens_hsa047281.90230936
14Insulin secretion_Homo sapiens_hsa049111.88593939
15Salivary secretion_Homo sapiens_hsa049701.80958601
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80851188
17Cholinergic synapse_Homo sapiens_hsa047251.75279545
18Gastric acid secretion_Homo sapiens_hsa049711.74710981
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62180069
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59418010
21Renin secretion_Homo sapiens_hsa049241.56681408
22Type II diabetes mellitus_Homo sapiens_hsa049301.51366102
23Oxytocin signaling pathway_Homo sapiens_hsa049211.47630079
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47220767
25Glioma_Homo sapiens_hsa052141.45555479
26Cocaine addiction_Homo sapiens_hsa050301.45053334
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41657739
28Adherens junction_Homo sapiens_hsa045201.40870527
29Long-term depression_Homo sapiens_hsa047301.40362785
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38892700
31GnRH signaling pathway_Homo sapiens_hsa049121.38482842
32Estrogen signaling pathway_Homo sapiens_hsa049151.31162278
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29214431
34Gap junction_Homo sapiens_hsa045401.27677377
35cAMP signaling pathway_Homo sapiens_hsa040241.22909400
36Taste transduction_Homo sapiens_hsa047421.21014791
37Calcium signaling pathway_Homo sapiens_hsa040201.17273024
38Lysine degradation_Homo sapiens_hsa003101.17106087
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15265242
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14976774
41Dorso-ventral axis formation_Homo sapiens_hsa043201.14173418
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13759236
43ErbB signaling pathway_Homo sapiens_hsa040121.13156384
44Axon guidance_Homo sapiens_hsa043601.12998222
45Melanogenesis_Homo sapiens_hsa049161.11583677
46Serotonergic synapse_Homo sapiens_hsa047261.11491765
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09869569
48ECM-receptor interaction_Homo sapiens_hsa045121.09298280
49mTOR signaling pathway_Homo sapiens_hsa041501.08828036
50Thyroid cancer_Homo sapiens_hsa052161.07924846
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07899856
52MicroRNAs in cancer_Homo sapiens_hsa052061.05250086
53Phototransduction_Homo sapiens_hsa047441.04787663
54Endometrial cancer_Homo sapiens_hsa052130.98972003
55Acute myeloid leukemia_Homo sapiens_hsa052210.98251379
56Prostate cancer_Homo sapiens_hsa052150.98067452
57B cell receptor signaling pathway_Homo sapiens_hsa046620.95559712
58Thyroid hormone synthesis_Homo sapiens_hsa049180.95401277
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95229006
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.92022450
61Small cell lung cancer_Homo sapiens_hsa052220.89823468
62Dilated cardiomyopathy_Homo sapiens_hsa054140.88978064
63Prion diseases_Homo sapiens_hsa050200.88371142
64Amoebiasis_Homo sapiens_hsa051460.87696413
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.86566026
66Non-small cell lung cancer_Homo sapiens_hsa052230.85841066
67Oocyte meiosis_Homo sapiens_hsa041140.84746163
68Pancreatic secretion_Homo sapiens_hsa049720.84728543
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84415708
70Glucagon signaling pathway_Homo sapiens_hsa049220.82444817
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.82185354
72Notch signaling pathway_Homo sapiens_hsa043300.79075664
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78612615
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77884567
75Choline metabolism in cancer_Homo sapiens_hsa052310.77841569
76Renal cell carcinoma_Homo sapiens_hsa052110.77719537
77VEGF signaling pathway_Homo sapiens_hsa043700.74889368
78MAPK signaling pathway_Homo sapiens_hsa040100.73050416
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70968820
80Insulin signaling pathway_Homo sapiens_hsa049100.70550634
81Rap1 signaling pathway_Homo sapiens_hsa040150.70432803
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69476998
83Colorectal cancer_Homo sapiens_hsa052100.68700094
84Bile secretion_Homo sapiens_hsa049760.68214202
85FoxO signaling pathway_Homo sapiens_hsa040680.66948006
86Wnt signaling pathway_Homo sapiens_hsa043100.66882302
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65926534
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65334843
89Protein digestion and absorption_Homo sapiens_hsa049740.64774365
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61189012
91HIF-1 signaling pathway_Homo sapiens_hsa040660.60867738
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59689963
93Ras signaling pathway_Homo sapiens_hsa040140.59543803
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58703708
95Proteoglycans in cancer_Homo sapiens_hsa052050.57682427
96Pathways in cancer_Homo sapiens_hsa052000.57447390
97Endocytosis_Homo sapiens_hsa041440.56079090
98Circadian rhythm_Homo sapiens_hsa047100.54776834
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.54480807
100Chronic myeloid leukemia_Homo sapiens_hsa052200.53077041
101Focal adhesion_Homo sapiens_hsa045100.52843553
102Insulin resistance_Homo sapiens_hsa049310.51922495
103AMPK signaling pathway_Homo sapiens_hsa041520.50725668
104Inositol phosphate metabolism_Homo sapiens_hsa005620.50720919
105Hippo signaling pathway_Homo sapiens_hsa043900.50653162
106Prolactin signaling pathway_Homo sapiens_hsa049170.50164657
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.47754022
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46967873
109Platelet activation_Homo sapiens_hsa046110.46438353
110Collecting duct acid secretion_Homo sapiens_hsa049660.45049292
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44957044
112Hedgehog signaling pathway_Homo sapiens_hsa043400.44525395
113Ovarian steroidogenesis_Homo sapiens_hsa049130.44130683
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43961210
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43768193
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42472981
117Pancreatic cancer_Homo sapiens_hsa052120.42417189
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40793633
119Alcoholism_Homo sapiens_hsa050340.39924622
120Tight junction_Homo sapiens_hsa045300.39536706

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