TRIM45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)9.60263360
2protein localization to cilium (GO:0061512)6.37800742
3regulation of chromatin binding (GO:0035561)6.13975642
4regulation of cilium movement (GO:0003352)5.93144086
5sensory perception of chemical stimulus (GO:0007606)5.69780073
6protein insertion into membrane (GO:0051205)5.69034317
7axonemal dynein complex assembly (GO:0070286)4.77095741
8cilium movement (GO:0003341)4.77025515
9microtubule severing (GO:0051013)4.67697005
10protein polyglutamylation (GO:0018095)4.57682588
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.43045806
12epithelial cilium movement (GO:0003351)4.37100923
13binding of sperm to zona pellucida (GO:0007339)4.34246703
14sperm-egg recognition (GO:0035036)4.08168497
15regulation of microtubule-based movement (GO:0060632)4.02218469
16acrosome reaction (GO:0007340)3.93903864
17limb bud formation (GO:0060174)3.84686674
18cell-cell recognition (GO:0009988)3.73593610
19replication fork processing (GO:0031297)3.70907600
20acrosome assembly (GO:0001675)3.60916507
21axoneme assembly (GO:0035082)3.53365142
22sperm motility (GO:0030317)3.51110004
23negative regulation of microtubule polymerization (GO:0031115)3.50551817
24nucleosome disassembly (GO:0006337)3.47570168
25protein-DNA complex disassembly (GO:0032986)3.47570168
26chromatin remodeling at centromere (GO:0031055)3.42224481
27behavioral response to nicotine (GO:0035095)3.24233445
28cilium or flagellum-dependent cell motility (GO:0001539)3.24062061
29DNA double-strand break processing (GO:0000729)3.21363561
30cilium morphogenesis (GO:0060271)3.20547211
31regulation of DNA endoreduplication (GO:0032875)3.12032607
32ventricular system development (GO:0021591)3.11803174
33somite development (GO:0061053)3.11085015
34regulation of meiosis I (GO:0060631)3.09472200
35spermatid nucleus differentiation (GO:0007289)3.08830684
36male meiosis (GO:0007140)3.07554675
37otic vesicle formation (GO:0030916)3.05516690
38CENP-A containing nucleosome assembly (GO:0034080)3.03088639
39intraciliary transport (GO:0042073)3.02893941
40UTP biosynthetic process (GO:0006228)3.02873423
41viral transcription (GO:0019083)3.01845280
42nonmotile primary cilium assembly (GO:0035058)3.01218901
43DNA replication checkpoint (GO:0000076)3.00747842
44cell wall macromolecule metabolic process (GO:0044036)2.95440668
45cell wall macromolecule catabolic process (GO:0016998)2.95440668
46translational elongation (GO:0006414)2.95156239
47presynaptic membrane assembly (GO:0097105)2.95044747
48auditory receptor cell differentiation (GO:0042491)2.93103921
49regulation of translation, ncRNA-mediated (GO:0045974)2.92171889
50negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.92171889
51negative regulation of translation, ncRNA-mediated (GO:0040033)2.92171889
52activation of protein kinase A activity (GO:0034199)2.92064539
53positive regulation of male gonad development (GO:2000020)2.91759110
54spermatid development (GO:0007286)2.90932972
55regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.89987965
56translational termination (GO:0006415)2.89944845
57somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88195020
58somatic hypermutation of immunoglobulin genes (GO:0016446)2.88195020
59disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.87939647
60killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.87939647
61negative regulation of DNA-dependent DNA replication (GO:2000104)2.87875019
62maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85970446
63ncRNA 3-end processing (GO:0043628)2.85626611
64adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.85276543
65cornea development in camera-type eye (GO:0061303)2.83803632
66fusion of sperm to egg plasma membrane (GO:0007342)2.83289576
67chromosome condensation (GO:0030261)2.82852246
68neutrophil mediated immunity (GO:0002446)2.82791673
69DNA unwinding involved in DNA replication (GO:0006268)2.80595017
70histone exchange (GO:0043486)2.80172411
71peptidyl-lysine dimethylation (GO:0018027)2.79785313
72regulation of translational fidelity (GO:0006450)2.78898479
73guanosine-containing compound biosynthetic process (GO:1901070)2.74817778
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74421893
75mitochondrial respiratory chain complex I assembly (GO:0032981)2.74421893
76NADH dehydrogenase complex assembly (GO:0010257)2.74421893
77GTP biosynthetic process (GO:0006183)2.73629388
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72259879
79peptidyl-arginine methylation (GO:0018216)2.72115982
80peptidyl-arginine N-methylation (GO:0035246)2.72115982
81regulation of non-canonical Wnt signaling pathway (GO:2000050)2.71883165
82peptidyl-arginine omega-N-methylation (GO:0035247)2.71140205
83microtubule bundle formation (GO:0001578)2.70725530
84glucocorticoid receptor signaling pathway (GO:0042921)2.68793342
85motile cilium assembly (GO:0044458)2.67693100
86synaptonemal complex organization (GO:0070193)2.67638471
87cerebellar Purkinje cell layer development (GO:0021680)2.67564540
88synaptonemal complex assembly (GO:0007130)2.64841988
89negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64696491
90DNA strand renaturation (GO:0000733)2.64150169
91UTP metabolic process (GO:0046051)2.63882720
92SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.63154041
93ribosomal small subunit assembly (GO:0000028)2.63133408
94cell proliferation in forebrain (GO:0021846)2.63041895
95regulation of mitotic spindle checkpoint (GO:1903504)2.62636121
96regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62636121
97pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.62367346
98protein complex disassembly (GO:0043241)2.62098291
99regulation of nuclear cell cycle DNA replication (GO:0033262)2.62028073
100resolution of meiotic recombination intermediates (GO:0000712)2.61884509
101regulation of male gonad development (GO:2000018)2.61126300
102dopamine receptor signaling pathway (GO:0007212)2.59678911
103respiratory chain complex IV assembly (GO:0008535)2.59610954
104protein targeting to ER (GO:0045047)2.58989463
105regulation of protein kinase A signaling (GO:0010738)2.58909890
106presynaptic membrane organization (GO:0097090)2.58638829
107synapsis (GO:0007129)2.58426745
108regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.57574190
109protein complex biogenesis (GO:0070271)2.57317401
110single fertilization (GO:0007338)2.57176653
111cotranslational protein targeting to membrane (GO:0006613)2.56957808
112mating behavior (GO:0007617)2.55388234
113detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54036981
114establishment of protein localization to mitochondrial membrane (GO:0090151)2.53423012
115dorsal/ventral axis specification (GO:0009950)2.52865812
116DNA packaging (GO:0006323)2.52431503
117cellular protein complex disassembly (GO:0043624)2.51576145
118neurogenesis (GO:0022008)2.50739676
119retinal ganglion cell axon guidance (GO:0031290)2.50484438
120establishment of protein localization to endoplasmic reticulum (GO:0072599)2.49579561
121macromolecular complex disassembly (GO:0032984)2.49561049
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.47825409
123meiotic chromosome segregation (GO:0045132)2.46755221
124regulation of mesoderm development (GO:2000380)2.45832187
125translational initiation (GO:0006413)2.45300227
126heterochromatin organization (GO:0070828)2.45090887
127kidney morphogenesis (GO:0060993)2.44446184
128microtubule-based movement (GO:0007018)2.44411733
129recombinational repair (GO:0000725)2.44128171
130histone arginine methylation (GO:0034969)2.43447658
131calcium ion-dependent exocytosis (GO:0017156)2.43409920
132microtubule depolymerization (GO:0007019)2.43163766
133pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.42348423
134protein localization to kinetochore (GO:0034501)2.41862619
135double-strand break repair via homologous recombination (GO:0000724)2.40585032
136intra-S DNA damage checkpoint (GO:0031573)2.40404090
137positive regulation of gastrulation (GO:2000543)2.39849239
138negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.39633008
139negative regulation of axon extension involved in axon guidance (GO:0048843)2.39607813
140leukocyte mediated cytotoxicity (GO:0001909)2.39606257
141chromatin silencing (GO:0006342)2.39030606
142CTP metabolic process (GO:0046036)2.38585458
143CTP biosynthetic process (GO:0006241)2.38585458
144multicellular organism reproduction (GO:0032504)2.38038245
145behavioral response to ethanol (GO:0048149)2.38006820
146mitochondrial respiratory chain complex assembly (GO:0033108)2.37731333
147protein localization to chromosome, centromeric region (GO:0071459)2.37342747
148pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.35655948
149regulation of collateral sprouting (GO:0048670)2.35496574
150DNA damage response, detection of DNA damage (GO:0042769)2.35266901
151pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.35229306
152DNA replication-independent nucleosome assembly (GO:0006336)2.34989359
153DNA replication-independent nucleosome organization (GO:0034724)2.34989359
154protein K6-linked ubiquitination (GO:0085020)2.34024110
155response to pheromone (GO:0019236)2.32185742
156protein localization to endoplasmic reticulum (GO:0070972)2.31849627
157sequestering of actin monomers (GO:0042989)2.31130379
158kinetochore assembly (GO:0051382)2.31077515
159centriole replication (GO:0007099)2.31019533
160negative regulation of axon guidance (GO:1902668)2.30497736
161cell recognition (GO:0008037)2.30110684
162sympathetic nervous system development (GO:0048485)2.29566439
163spinal cord development (GO:0021510)2.28920580
164kinetochore organization (GO:0051383)2.28320952
165L-serine metabolic process (GO:0006563)2.27253215
166water-soluble vitamin biosynthetic process (GO:0042364)2.24870538
167reciprocal meiotic recombination (GO:0007131)2.22120810
168reciprocal DNA recombination (GO:0035825)2.22120810
169DNA replication-dependent nucleosome organization (GO:0034723)2.22049725
170DNA replication-dependent nucleosome assembly (GO:0006335)2.22049725
171peptidyl-histidine modification (GO:0018202)2.21185326
172cytochrome complex assembly (GO:0017004)2.21108807
173sulfation (GO:0051923)2.20439597
174postreplication repair (GO:0006301)2.19090623
175lung-associated mesenchyme development (GO:0060484)2.17787990
176outer ear morphogenesis (GO:0042473)2.17116086
177keratinocyte development (GO:0003334)2.16704737
178neuron fate determination (GO:0048664)2.15774938
179nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.15177314
180sex differentiation (GO:0007548)2.15152774
181prenylation (GO:0097354)2.15149450
182protein prenylation (GO:0018342)2.15149450
183somite rostral/caudal axis specification (GO:0032525)2.14056516
184hindbrain development (GO:0030902)2.12744524
185regulation of posttranscriptional gene silencing (GO:0060147)2.10306693
186regulation of gene silencing by miRNA (GO:0060964)2.10306693
187regulation of gene silencing by RNA (GO:0060966)2.10306693
188appendage development (GO:0048736)2.09317799
189limb development (GO:0060173)2.09317799
190exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.09013239
191DNA integration (GO:0015074)2.08164542
192pituitary gland development (GO:0021983)2.07898891
193cilium organization (GO:0044782)2.07858334
194positive regulation of meiosis (GO:0045836)2.06410357
195response to nitrosative stress (GO:0051409)2.05430157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.42254041
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.74235623
3E2F7_22180533_ChIP-Seq_HELA_Human3.69623729
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.68844566
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.79145072
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66919702
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.66355143
8GBX2_23144817_ChIP-Seq_PC3_Human2.65860919
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.58567411
10FUS_26573619_Chip-Seq_HEK293_Human2.54027788
11EWS_26573619_Chip-Seq_HEK293_Human2.48308682
12VDR_22108803_ChIP-Seq_LS180_Human2.47806035
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41277341
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31425094
15IGF1R_20145208_ChIP-Seq_DFB_Human2.24200156
16ZNF263_19887448_ChIP-Seq_K562_Human2.23283985
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22961545
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21872447
19MYC_22102868_ChIP-Seq_BL_Human2.21293148
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16266121
21POU5F1_16153702_ChIP-ChIP_HESCs_Human2.08308910
22VDR_21846776_ChIP-Seq_THP-1_Human2.01763540
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01681275
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00536671
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98649079
26* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.95972062
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95229632
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95135241
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93325694
30* P300_19829295_ChIP-Seq_ESCs_Human1.88378373
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86906605
32CIITA_25753668_ChIP-Seq_RAJI_Human1.86504319
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84095824
34XRN2_22483619_ChIP-Seq_HELA_Human1.83235455
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81973804
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.77988182
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77124217
38IRF1_19129219_ChIP-ChIP_H3396_Human1.75647582
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75627176
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75448822
41TTF2_22483619_ChIP-Seq_HELA_Human1.73181521
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72743394
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71997083
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71109527
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.62999293
46SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.62243208
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.61636822
48MYC_18940864_ChIP-ChIP_HL60_Human1.61489767
49ELK1_19687146_ChIP-ChIP_HELA_Human1.60111404
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59336703
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56912352
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56172352
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.55208866
54* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54759097
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54199588
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49080836
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.47463652
58ER_23166858_ChIP-Seq_MCF-7_Human1.45771780
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45063875
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44159612
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.43449645
62RNF2_27304074_Chip-Seq_NSC_Mouse1.41884392
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40831773
64* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39794520
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36632516
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36275170
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.35070370
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.34312179
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34131713
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.33797098
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33663297
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33649391
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.33626725
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32803799
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32511876
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32465649
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.31503342
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.28035567
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27261627
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.27047325
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25910082
82* E2F1_21310950_ChIP-Seq_MCF-7_Human1.25162032
83SMAD4_21799915_ChIP-Seq_A2780_Human1.25008093
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.23881895
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23304275
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23015704
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22400873
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22321038
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22077858
90AR_25329375_ChIP-Seq_VCAP_Human1.21871949
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.20556606
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.20249078
93GABP_19822575_ChIP-Seq_HepG2_Human1.19631170
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18918532
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18434790
96* LXR_22292898_ChIP-Seq_THP-1_Human1.18312558
97TAF15_26573619_Chip-Seq_HEK293_Human1.17489246
98BCAT_22108803_ChIP-Seq_LS180_Human1.16979563
99FOXP1_21924763_ChIP-Seq_HESCs_Human1.16775969
100* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16589000
101EGR1_19374776_ChIP-ChIP_THP-1_Human1.16282400
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16153996
103FOXP3_21729870_ChIP-Seq_TREG_Human1.15157997
104RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14788346
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13385385
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12804887
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12298286
108CBP_20019798_ChIP-Seq_JUKART_Human1.11725947
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11725947
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11329368
111ZNF274_21170338_ChIP-Seq_K562_Hela1.10666524
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10325085
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10027434
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10027434
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09131372
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08632648
117SOX9_26525672_Chip-Seq_HEART_Mouse1.06917285
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06587162
119KDM2B_26808549_Chip-Seq_DND41_Human1.06322369
120STAT3_23295773_ChIP-Seq_U87_Human1.05192535
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05118659
122SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04514025
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03888349
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03232840
125* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01750203
126TCF4_22108803_ChIP-Seq_LS180_Human1.01636401
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01012112
128TCF4_23295773_ChIP-Seq_U87_Human1.00925012
129SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00457658
130E2F1_20622854_ChIP-Seq_HELA_Human0.99774560
131GABP_17652178_ChIP-ChIP_JURKAT_Human0.99571543
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99163107
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.98973816
134* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98936477
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98887076
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98819680
137* RUNX2_22187159_ChIP-Seq_PCA_Human0.98617682
138TCF7_22412390_ChIP-Seq_EML_Mouse0.98439930
139MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98414731
140KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98030006
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.97803121
142TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97706720
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97643798
144SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97630645
145TP53_22573176_ChIP-Seq_HFKS_Human0.97430292
146WDR5_24793694_ChIP-Seq_LNCAP_Human0.97215673
147VDR_24763502_ChIP-Seq_THP-1_Human0.97067850
148BCOR_27268052_Chip-Seq_Bcells_Human0.96326967
149TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96303329
150SOX2_19829295_ChIP-Seq_ESCs_Human0.95777807
151NANOG_19829295_ChIP-Seq_ESCs_Human0.95777807
152TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95324453
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95238384
154KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94965014
155STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94546912
156EED_16625203_ChIP-ChIP_MESCs_Mouse0.94254021
157CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92834199
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92822778
159PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92528678
160CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92412704
161* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92179323
162KDM2B_26808549_Chip-Seq_K562_Human0.91781032
163PHF8_20622854_ChIP-Seq_HELA_Human0.91637590
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90922319
165CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90724872
166KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90607156
167FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89934739
168DCP1A_22483619_ChIP-Seq_HELA_Human0.89863417
169FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88974550
170P68_20966046_ChIP-Seq_HELA_Human0.88744151
171PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87751324
172TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87288809
173ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86885828
174VDR_23849224_ChIP-Seq_CD4+_Human0.86827635
175CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86428972
176PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86019870
177NANOG_18555785_Chip-Seq_ESCs_Mouse0.85922736
178STAT1_20625510_ChIP-Seq_HELA_Human0.85554406
179KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82836136
180NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82274343
181REST_21632747_ChIP-Seq_MESCs_Mouse0.82012346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction7.96756311
2MP0005410_abnormal_fertilization3.88801220
3MP0006292_abnormal_olfactory_placode3.43727105
4MP0008789_abnormal_olfactory_epithelium3.21093232
5MP0003123_paternal_imprinting2.84088647
6MP0002653_abnormal_ependyma_morphology2.83216426
7MP0005394_taste/olfaction_phenotype2.83013317
8MP0005499_abnormal_olfactory_system2.83013317
9MP0008877_abnormal_DNA_methylation2.60043615
10MP0005623_abnormal_meninges_morphology2.58779429
11MP0005645_abnormal_hypothalamus_physiol2.33114958
12MP0003693_abnormal_embryo_hatching2.30245035
13MP0003880_abnormal_central_pattern2.20846186
14MP0003122_maternal_imprinting2.20449556
15MP0002184_abnormal_innervation2.16357714
16MP0002938_white_spotting2.07136588
17MP0001293_anophthalmia2.06905767
18MP0005174_abnormal_tail_pigmentation1.92000456
19MP0003136_yellow_coat_color1.83565279
20MP0003937_abnormal_limbs/digits/tail_de1.79618051
21MP0002160_abnormal_reproductive_system1.75876550
22MP0003698_abnormal_male_reproductive1.75225794
23MP0004859_abnormal_synaptic_plasticity1.73402912
24MP0000566_synostosis1.71452058
25MP0003787_abnormal_imprinting1.69412049
26MP0006072_abnormal_retinal_apoptosis1.69042356
27MP0000537_abnormal_urethra_morphology1.68629306
28MP0001485_abnormal_pinna_reflex1.67792172
29MP0003121_genomic_imprinting1.64546676
30MP0005551_abnormal_eye_electrophysiolog1.63651629
31MP0002736_abnormal_nociception_after1.62099582
32MP0004145_abnormal_muscle_electrophysio1.57640800
33MP0003890_abnormal_embryonic-extraembry1.51510565
34MP0002210_abnormal_sex_determination1.50749816
35MP0002234_abnormal_pharynx_morphology1.47730173
36MP0002638_abnormal_pupillary_reflex1.45450650
37MP0003755_abnormal_palate_morphology1.44088532
38MP0001929_abnormal_gametogenesis1.42489568
39MP0006276_abnormal_autonomic_nervous1.41179773
40MP0005253_abnormal_eye_physiology1.40583358
41MP0004233_abnormal_muscle_weight1.38965795
42MP0005646_abnormal_pituitary_gland1.38555567
43MP0003635_abnormal_synaptic_transmissio1.38465897
44MP0003119_abnormal_digestive_system1.37657310
45MP0002751_abnormal_autonomic_nervous1.37636357
46MP0003718_maternal_effect1.37095645
47MP0000383_abnormal_hair_follicle1.34410876
48MP0001286_abnormal_eye_development1.30676560
49MP0002734_abnormal_mechanical_nocicepti1.29040243
50MP0001968_abnormal_touch/_nociception1.25374501
51MP0002837_dystrophic_cardiac_calcinosis1.24894323
52MP0009046_muscle_twitch1.20800389
53MP0005423_abnormal_somatic_nervous1.19596754
54MP0001145_abnormal_male_reproductive1.19025712
55MP0003011_delayed_dark_adaptation1.18163714
56MP0004957_abnormal_blastocyst_morpholog1.16690576
57MP0003567_abnormal_fetal_cardiomyocyte1.16260198
58MP0002557_abnormal_social/conspecific_i1.15941980
59MP0002272_abnormal_nervous_system1.14652446
60MP0002282_abnormal_trachea_morphology1.14648199
61MP0004811_abnormal_neuron_physiology1.14546453
62MP0003942_abnormal_urinary_system1.13611229
63MP0003861_abnormal_nervous_system1.12757675
64MP0003938_abnormal_ear_development1.12555950
65MP0002882_abnormal_neuron_morphology1.12390545
66MP0002877_abnormal_melanocyte_morpholog1.10628781
67MP0000427_abnormal_hair_cycle1.10450505
68MP0000049_abnormal_middle_ear1.10253785
69MP0000778_abnormal_nervous_system1.09783478
70MP0002752_abnormal_somatic_nervous1.09744107
71MP0009379_abnormal_foot_pigmentation1.09043704
72MP0002152_abnormal_brain_morphology1.08909506
73MP0005391_vision/eye_phenotype1.08009093
74MP0004133_heterotaxia1.07023378
75MP0005171_absent_coat_pigmentation1.05699143
76MP0000372_irregular_coat_pigmentation1.05676497
77MP0003646_muscle_fatigue1.05540712
78MP0009053_abnormal_anal_canal1.05189517
79MP0004885_abnormal_endolymph1.04743654
80MP0003195_calcinosis1.04395438
81MP0009333_abnormal_splenocyte_physiolog1.04384071
82MP0002161_abnormal_fertility/fecundity1.04255600
83MP0000751_myopathy1.03906067
84MP0009250_abnormal_appendicular_skeleto1.03687757
85MP0003941_abnormal_skin_development1.03334870
86MP0005195_abnormal_posterior_eye1.03307598
87MP0003111_abnormal_nucleus_morphology1.03154711
88MP0010030_abnormal_orbit_morphology1.03107545
89MP0001730_embryonic_growth_arrest1.02565556
90MP0000647_abnormal_sebaceous_gland1.00088596
91MP0004270_analgesia0.99483507
92MP0002063_abnormal_learning/memory/cond0.98952907
93MP0001188_hyperpigmentation0.97494016
94MP0010094_abnormal_chromosome_stability0.96924169
95MP0002233_abnormal_nose_morphology0.96908376
96MP0000653_abnormal_sex_gland0.96037607
97MP0001299_abnormal_eye_distance/0.95869650
98MP0000026_abnormal_inner_ear0.94345571
99MP0002697_abnormal_eye_size0.93247813
100MP0004215_abnormal_myocardial_fiber0.92988015
101MP0004858_abnormal_nervous_system0.92879689
102MP0009697_abnormal_copulation0.92062688
103MP0000534_abnormal_ureter_morphology0.90968541
104MP0010678_abnormal_skin_adnexa0.90718691
105MP0003137_abnormal_impulse_conducting0.89797141
106MP0002249_abnormal_larynx_morphology0.89487761
107MP0003879_abnormal_hair_cell0.87894408
108MP0003878_abnormal_ear_physiology0.87739538
109MP0005377_hearing/vestibular/ear_phenot0.87739538
110MP0001486_abnormal_startle_reflex0.85258419
111MP0001270_distended_abdomen0.85223102
112MP0003935_abnormal_craniofacial_develop0.84497304
113MP0002084_abnormal_developmental_patter0.84381849
114MP0004197_abnormal_fetal_growth/weight/0.83278936
115MP0000350_abnormal_cell_proliferation0.83090576
116MP0001324_abnormal_eye_pigmentation0.82976996
117MP0001970_abnormal_pain_threshold0.82670517
118MP0001529_abnormal_vocalization0.82666948
119MP0002116_abnormal_craniofacial_bone0.81480064
120MP0003077_abnormal_cell_cycle0.81134424
121MP0005248_abnormal_Harderian_gland0.79814446
122MP0009384_cardiac_valve_regurgitation0.79010655
123MP0000428_abnormal_craniofacial_morphol0.78069079
124MP0002111_abnormal_tail_morphology0.78004148
125MP0000955_abnormal_spinal_cord0.77208319
126MP0004142_abnormal_muscle_tone0.76411992
127MP0002572_abnormal_emotion/affect_behav0.76406076
128MP0000631_abnormal_neuroendocrine_gland0.76168380
129MP0008058_abnormal_DNA_repair0.76119554
130MP0002085_abnormal_embryonic_tissue0.76041766
131MP0003385_abnormal_body_wall0.75444378
132MP0002735_abnormal_chemical_nociception0.75172163
133MP0002102_abnormal_ear_morphology0.75148734
134MP0002064_seizures0.74114054
135MP0005367_renal/urinary_system_phenotyp0.73992301
136MP0000516_abnormal_urinary_system0.73992301
137MP0002089_abnormal_postnatal_growth/wei0.73745709
138MP0001905_abnormal_dopamine_level0.71792834
139MP0009672_abnormal_birth_weight0.70237892
140MP0008932_abnormal_embryonic_tissue0.69588507
141MP0001697_abnormal_embryo_size0.69504694
142MP0001963_abnormal_hearing_physiology0.69049087
143MP0002081_perinatal_lethality0.68912455
144MP0002733_abnormal_thermal_nociception0.68884605
145MP0010307_abnormal_tumor_latency0.68575086
146MP0002067_abnormal_sensory_capabilities0.67965887
147MP0000003_abnormal_adipose_tissue0.67917555
148MP0005389_reproductive_system_phenotype0.67270987
149MP0002080_prenatal_lethality0.65841938

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.68794369
2Abnormal respiratory epithelium morphology (HP:0012253)6.65664259
3Abnormal respiratory motile cilium morphology (HP:0005938)6.65664259
4Abnormal respiratory motile cilium physiology (HP:0012261)5.94594852
5Abnormal ciliary motility (HP:0012262)5.62393989
6Rhinitis (HP:0012384)5.17270312
7Absent/shortened dynein arms (HP:0200106)4.96206782
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.96206782
9Thrombocytosis (HP:0001894)3.39532419
10Nasal polyposis (HP:0100582)3.33742519
11Retinal dysplasia (HP:0007973)3.28842152
12Nephronophthisis (HP:0000090)3.08574014
13Chronic bronchitis (HP:0004469)3.05108872
14Severe visual impairment (HP:0001141)3.03269770
15Abnormality of the labia minora (HP:0012880)3.01725125
16Pancreatic cysts (HP:0001737)3.00983011
17Septo-optic dysplasia (HP:0100842)2.81380676
18Molar tooth sign on MRI (HP:0002419)2.79561081
19Abnormality of midbrain morphology (HP:0002418)2.79561081
20Abnormality of dentin (HP:0010299)2.74540526
21Bronchiectasis (HP:0002110)2.74221421
22Rib fusion (HP:0000902)2.66520126
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64494761
24Broad distal phalanx of finger (HP:0009836)2.60250393
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.59155850
26Chromsome breakage (HP:0040012)2.50134571
27Limb dystonia (HP:0002451)2.40846375
28Abnormality of the nasal mucosa (HP:0000433)2.40415354
29Anophthalmia (HP:0000528)2.39149913
30Pendular nystagmus (HP:0012043)2.36893536
31Dysphonia (HP:0001618)2.34841793
32Abnormal lung lobation (HP:0002101)2.34275705
33Meckel diverticulum (HP:0002245)2.33718307
34Ectopic kidney (HP:0000086)2.33486856
35Congenital stationary night blindness (HP:0007642)2.31548675
36Abnormality of cells of the erythroid lineage (HP:0012130)2.30815115
37Infertility (HP:0000789)2.30751204
38Bifid tongue (HP:0010297)2.30681774
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.26695423
40Abnormality of the ileum (HP:0001549)2.26688406
41Atonic seizures (HP:0010819)2.24826914
42Gait imbalance (HP:0002141)2.24225646
43Supernumerary spleens (HP:0009799)2.22508718
44Triphalangeal thumb (HP:0001199)2.14115702
45Male pseudohermaphroditism (HP:0000037)2.11214404
46Intestinal atresia (HP:0011100)2.09976757
47Acute necrotizing encephalopathy (HP:0006965)2.09946489
48Epiphyseal dysplasia (HP:0002656)2.09647757
49Cystic liver disease (HP:0006706)2.09634713
50Recurrent sinusitis (HP:0011108)2.08839424
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07744671
52Bony spicule pigmentary retinopathy (HP:0007737)2.06912212
53Optic nerve hypoplasia (HP:0000609)2.06294314
54Renal hypoplasia (HP:0000089)2.05574226
55Congenital primary aphakia (HP:0007707)2.04727141
56Colon cancer (HP:0003003)2.01902812
57Acute encephalopathy (HP:0006846)2.00612059
58Postaxial foot polydactyly (HP:0001830)1.99180528
59Bile duct proliferation (HP:0001408)1.99016312
60Abnormal biliary tract physiology (HP:0012439)1.99016312
61Bilateral microphthalmos (HP:0007633)1.98507072
62Medial flaring of the eyebrow (HP:0010747)1.97865895
63Myokymia (HP:0002411)1.97822581
64Preaxial hand polydactyly (HP:0001177)1.97564222
65Abnormality of chromosome stability (HP:0003220)1.96422431
66Absent thumb (HP:0009777)1.95252260
67Patellar aplasia (HP:0006443)1.94814006
68Abnormal number of erythroid precursors (HP:0012131)1.94238265
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93255990
70Short 4th metacarpal (HP:0010044)1.93255990
71Hyperglycinuria (HP:0003108)1.92679506
72Irregular epiphyses (HP:0010582)1.91908022
73Abnormality of the renal cortex (HP:0011035)1.91459803
74Adrenal hypoplasia (HP:0000835)1.91239196
75Abnormality of the preputium (HP:0100587)1.88738447
76Hyperventilation (HP:0002883)1.88511632
77Mitochondrial inheritance (HP:0001427)1.88417680
78Recurrent otitis media (HP:0000403)1.87842118
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.87562899
80Thoracolumbar scoliosis (HP:0002944)1.87508014
81Aplasia/Hypoplasia of the patella (HP:0006498)1.86342115
82Facial cleft (HP:0002006)1.86033105
83Chronic hepatic failure (HP:0100626)1.85822433
84Abnormality of macular pigmentation (HP:0008002)1.85648995
85Abnormality of the renal medulla (HP:0100957)1.84865000
86Volvulus (HP:0002580)1.84626359
87Anencephaly (HP:0002323)1.83883605
88Annular pancreas (HP:0001734)1.82923482
89Abnormality of the parathyroid morphology (HP:0011766)1.82919334
90Absent septum pellucidum (HP:0001331)1.82379182
91Insomnia (HP:0100785)1.82239757
92Progressive macrocephaly (HP:0004481)1.81875391
93Stenosis of the external auditory canal (HP:0000402)1.81311701
94Neoplasm of the adrenal cortex (HP:0100641)1.81126691
95Increased CSF lactate (HP:0002490)1.79965939
96Chorioretinal atrophy (HP:0000533)1.79640817
97Dandy-Walker malformation (HP:0001305)1.78814364
98Buphthalmos (HP:0000557)1.78419117
99Abnormality of the lower motor neuron (HP:0002366)1.78219048
100Bronchitis (HP:0012387)1.77691957
101Rhizomelia (HP:0008905)1.77582454
102Tubular atrophy (HP:0000092)1.77295417
103Small hand (HP:0200055)1.76455349
104Sloping forehead (HP:0000340)1.75699345
105Atresia of the external auditory canal (HP:0000413)1.75464329
106Visual hallucinations (HP:0002367)1.75184279
107Increased nuchal translucency (HP:0010880)1.74039888
108Abolished electroretinogram (ERG) (HP:0000550)1.74022713
109Hyperacusis (HP:0010780)1.73815342
110Asplenia (HP:0001746)1.73399369
111Hypoplastic pelvis (HP:0008839)1.72747608
112Hypoplastic ischia (HP:0003175)1.71805060
113Increased hepatocellular lipid droplets (HP:0006565)1.71414797
114Postaxial hand polydactyly (HP:0001162)1.70996827
115Hyperglycinemia (HP:0002154)1.70801564
116Maternal diabetes (HP:0009800)1.70481790
117Hepatocellular necrosis (HP:0001404)1.70405130
118Chronic sinusitis (HP:0011109)1.70354627
119Oligodactyly (hands) (HP:0001180)1.70166283
120Nephrogenic diabetes insipidus (HP:0009806)1.69220235
121Palpitations (HP:0001962)1.69176222
122Astigmatism (HP:0000483)1.67703140
123Abnormal mitochondria in muscle tissue (HP:0008316)1.67628180
124Adenoma sebaceum (HP:0009720)1.67442928
125Angiofibromas (HP:0010615)1.67442928
126Aganglionic megacolon (HP:0002251)1.67108366
127True hermaphroditism (HP:0010459)1.66567706
128Anosmia (HP:0000458)1.66547171
129Median cleft lip (HP:0000161)1.66277275
130Mitral regurgitation (HP:0001653)1.65874453
131Abnormality of the proximal phalanges of the hand (HP:0009834)1.65630497
132Vitreoretinal degeneration (HP:0000655)1.65226280
133Ependymoma (HP:0002888)1.64882522
134Abnormality of the carotid arteries (HP:0005344)1.64634093
135Abnormality of the duodenum (HP:0002246)1.64557957
136Deep palmar crease (HP:0006191)1.64095505
137Duodenal stenosis (HP:0100867)1.63882566
138Small intestinal stenosis (HP:0012848)1.63882566
139Sclerocornea (HP:0000647)1.63705266
140Congenital hepatic fibrosis (HP:0002612)1.63601902
141Diminished motivation (HP:0000745)1.63114190
142Spinal canal stenosis (HP:0003416)1.63011410
143Occipital encephalocele (HP:0002085)1.62904162
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.61608080
145Abnormal rod and cone electroretinograms (HP:0008323)1.61603187
146Narrow forehead (HP:0000341)1.60836741
147Abnormality of glycine metabolism (HP:0010895)1.60583083
148Abnormality of serine family amino acid metabolism (HP:0010894)1.60583083
149Sacral dimple (HP:0000960)1.59681329
150Oculomotor apraxia (HP:0000657)1.59316197
151Apathy (HP:0000741)1.58909285
152Pancreatic fibrosis (HP:0100732)1.56790356
153Renal duplication (HP:0000075)1.56696051
154Testicular neoplasm (HP:0010788)1.56192210
155Complete atrioventricular canal defect (HP:0001674)1.56010095
156Absent epiphyses (HP:0010577)1.55557053
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.55557053
158Degeneration of anterior horn cells (HP:0002398)1.55042307
159Abnormality of the anterior horn cell (HP:0006802)1.55042307
160Aplasia/Hypoplasia of the lens (HP:0008063)1.53727969
161Generalized hypotonia (HP:0001290)1.53178963
162Carpal bone hypoplasia (HP:0001498)1.52428668
163Nuclear cataract (HP:0100018)1.50977873
164Hand muscle atrophy (HP:0009130)1.49930737
165Concave nail (HP:0001598)1.49187298
166Lower limb asymmetry (HP:0100559)1.48918033
167Mild short stature (HP:0003502)1.48344454
168Reticulocytopenia (HP:0001896)1.48067512
169Vaginal atresia (HP:0000148)1.47796936
170Facial hemangioma (HP:0000329)1.47527330
171Broad palm (HP:0001169)1.45343231
172Hypoventilation (HP:0002791)1.45222731
173Pointed chin (HP:0000307)1.44811476
174Congenital glaucoma (HP:0001087)1.41517115
175Focal seizures (HP:0007359)1.40971961
176Poor coordination (HP:0002370)1.40266575
177Genital tract atresia (HP:0001827)1.40059003
178Selective tooth agenesis (HP:0001592)1.38862409
179Supranuclear gaze palsy (HP:0000605)1.38060228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.99046259
2PHKG23.91418917
3PHKG13.91418917
4BRSK23.51735764
5TESK13.42462847
6PKN23.20978824
7TNIK3.10993851
8FRK2.97091810
9EEF2K2.53929351
10VRK22.49372535
11TLK12.46409840
12MAP3K102.40481251
13CDK122.37043638
14ICK2.18536953
15BMPR1B2.12936901
16WNK32.12915002
17CDC72.03730828
18CASK2.01880663
19PDK32.00836668
20PDK42.00836668
21EIF2AK31.89725845
22TRIM281.85927269
23PLK41.79415461
24TAF11.78056990
25STK161.71623451
26GRK11.69706322
27LATS11.69309636
28NEK21.69178051
29ILK1.65650612
30PRKD31.65595712
31FGFR21.61496977
32BRSK11.61231841
33ZAK1.55422002
34CAMKK21.54891846
35ARAF1.52921576
36BUB11.51345333
37EPHA41.49427394
38OBSCN1.46007440
39PBK1.45786156
40SIK21.44781143
41OXSR11.39093512
42VRK11.37463850
43CAMK1G1.36853117
44PNCK1.33209182
45SRPK11.31504500
46ACVR1B1.23047542
47STK391.22650899
48MAP3K41.22483933
49DYRK31.21780568
50MAP3K91.17759408
51STK38L1.12101829
52DYRK21.11659522
53MINK11.11659490
54PIK3CA1.10461606
55ADRBK21.08060765
56PRPF4B1.07581411
57INSRR1.07195942
58CAMKK11.07082126
59MAPK131.04054077
60MUSK1.03829111
61WEE11.03389717
62PAK61.03242155
63ERBB31.02762516
64STK31.01629455
65NEK11.00016861
66BCR0.99788943
67TIE10.98362084
68CSNK1G30.96189003
69MKNK20.95495473
70RPS6KA20.94352320
71NTRK30.93375203
72CAMK1D0.92663893
73BRAF0.90713572
74WNK40.89556687
75CSNK1A1L0.85907867
76LIMK10.85822760
77PTK2B0.85786483
78PASK0.85090687
79TTK0.84991019
80PINK10.82510798
81TESK20.78913348
82NME10.78788816
83MAP4K20.78788702
84CSNK1G20.78108956
85MKNK10.75202656
86HIPK20.74917352
87NUAK10.73177283
88RIPK10.72866997
89KSR20.72506375
90TGFBR10.70848276
91ALK0.69940176
92UHMK10.68649783
93BCKDK0.68634073
94NTRK20.68352549
95STK240.68125410
96MAPK150.67240180
97MARK10.66150552
98CDK30.65047731
99PLK10.64651842
100DDR20.63266708
101CAMK2B0.62539421
102EPHB20.62338204
103MST40.61998834
104EIF2AK10.61711202
105PAK10.61422628
106DAPK30.61239775
107CDK70.61134371
108ATR0.60863269
109FES0.59601088
110CDK190.59441029
111AURKA0.59164497
112CAMK2D0.58717475
113SCYL20.58031607
114PRKCE0.57387100
115TSSK60.57003125
116DAPK10.55678574
117ATM0.55635439
118CDK140.54653424
119TNK20.54265292
120TYRO30.53875504
121CDK80.53837036
122MAP2K70.53121661
123FGFR10.51933627
124PAK30.51363808
125MAP2K40.51068848
126CSNK1G10.50493566
127PLK30.50445729
128RET0.49868995
129RAF10.49845845
130PAK20.49734693
131CDK150.48979379
132PLK20.48179355
133CHEK10.47819671
134TTN0.46734949
135CDK180.46613089
136CDK11A0.45848749
137CHEK20.45744897
138KSR10.44182430
139MAPKAPK50.42276098
140PRKCG0.40484001
141ROCK20.39994727
142AURKB0.39813153
143CSNK1E0.39709108
144RPS6KA40.39528431
145CAMK2G0.37956596
146PDK10.37656619
147STK110.37294525
148MAP3K80.36984276
149PDK20.36571120
150LRRK20.36244855
151CDK20.36203829
152RPS6KB10.35840930
153EIF2AK20.35805556
154PKN10.34148787
155CSNK1D0.34121191
156FER0.33750179
157CAMK10.33301595
158AKT30.32922825
159CSNK1A10.32655876
160PRKAA10.31955482
161CSNK2A10.31433822
162CDK10.30863023

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047406.67791876
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.52922754
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.40724408
4Propanoate metabolism_Homo sapiens_hsa006402.34857068
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04831592
6Ribosome_Homo sapiens_hsa030101.89379023
7Oocyte meiosis_Homo sapiens_hsa041141.80817122
8N-Glycan biosynthesis_Homo sapiens_hsa005101.79779987
9Spliceosome_Homo sapiens_hsa030401.78206995
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72763755
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71956777
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70650922
13RNA degradation_Homo sapiens_hsa030181.70622070
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63579241
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61475769
16DNA replication_Homo sapiens_hsa030301.59941398
17RNA transport_Homo sapiens_hsa030131.55347118
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49971441
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48619564
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.47133727
21Glucagon signaling pathway_Homo sapiens_hsa049221.43995903
22Dopaminergic synapse_Homo sapiens_hsa047281.41151537
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35963725
24Circadian entrainment_Homo sapiens_hsa047131.35871450
25Estrogen signaling pathway_Homo sapiens_hsa049151.35108030
26Butanoate metabolism_Homo sapiens_hsa006501.34878580
27Alcoholism_Homo sapiens_hsa050341.33855961
28Phototransduction_Homo sapiens_hsa047441.33353587
29mRNA surveillance pathway_Homo sapiens_hsa030151.29770111
30Synaptic vesicle cycle_Homo sapiens_hsa047211.29260737
31Basal transcription factors_Homo sapiens_hsa030221.26808554
32Long-term potentiation_Homo sapiens_hsa047201.26296283
33Fatty acid elongation_Homo sapiens_hsa000621.25838032
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.25257559
35Nitrogen metabolism_Homo sapiens_hsa009101.23770722
36Cell cycle_Homo sapiens_hsa041101.23688911
37Insulin secretion_Homo sapiens_hsa049111.23239649
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23091167
39Gap junction_Homo sapiens_hsa045401.18791280
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17859723
41Nicotine addiction_Homo sapiens_hsa050331.13922147
42Cholinergic synapse_Homo sapiens_hsa047251.13797378
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13488420
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12145492
45Base excision repair_Homo sapiens_hsa034101.08891701
46Parkinsons disease_Homo sapiens_hsa050121.06753683
47Amphetamine addiction_Homo sapiens_hsa050311.06687425
48Hippo signaling pathway_Homo sapiens_hsa043901.06494030
49Mismatch repair_Homo sapiens_hsa034301.06313319
50Huntingtons disease_Homo sapiens_hsa050161.05621204
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.04170697
52Steroid biosynthesis_Homo sapiens_hsa001001.04126871
53Caffeine metabolism_Homo sapiens_hsa002321.03972562
54Cardiac muscle contraction_Homo sapiens_hsa042601.03794741
55Melanogenesis_Homo sapiens_hsa049161.03408365
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01597695
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01387624
58Linoleic acid metabolism_Homo sapiens_hsa005911.00229657
59Thyroid hormone synthesis_Homo sapiens_hsa049180.99648702
60Ether lipid metabolism_Homo sapiens_hsa005650.99043423
61Vibrio cholerae infection_Homo sapiens_hsa051100.98946115
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97591310
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96967454
64Morphine addiction_Homo sapiens_hsa050320.96437624
65Systemic lupus erythematosus_Homo sapiens_hsa053220.96380907
66Tryptophan metabolism_Homo sapiens_hsa003800.93930594
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.93643881
68Taste transduction_Homo sapiens_hsa047420.92447969
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89660820
70Glioma_Homo sapiens_hsa052140.88981947
71Colorectal cancer_Homo sapiens_hsa052100.88755010
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88697686
73Glutamatergic synapse_Homo sapiens_hsa047240.88393504
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86202601
75Renin secretion_Homo sapiens_hsa049240.85284633
76cAMP signaling pathway_Homo sapiens_hsa040240.84991399
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84572601
78Cocaine addiction_Homo sapiens_hsa050300.84572546
79beta-Alanine metabolism_Homo sapiens_hsa004100.83425247
80Peroxisome_Homo sapiens_hsa041460.83202814
81Purine metabolism_Homo sapiens_hsa002300.83079149
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82711586
83Insulin signaling pathway_Homo sapiens_hsa049100.82029564
84Retinol metabolism_Homo sapiens_hsa008300.82005426
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81710835
86Fatty acid degradation_Homo sapiens_hsa000710.81677142
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81565760
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81124746
89GnRH signaling pathway_Homo sapiens_hsa049120.79581483
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79530823
91Endometrial cancer_Homo sapiens_hsa052130.79398738
92Chemical carcinogenesis_Homo sapiens_hsa052040.78796347
93Vitamin B6 metabolism_Homo sapiens_hsa007500.78476254
94Axon guidance_Homo sapiens_hsa043600.78018800
95One carbon pool by folate_Homo sapiens_hsa006700.77966143
96Thyroid cancer_Homo sapiens_hsa052160.77378128
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77352609
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75768265
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.75399837
100Gastric acid secretion_Homo sapiens_hsa049710.74902432
101Glutathione metabolism_Homo sapiens_hsa004800.74581127
102Lysine degradation_Homo sapiens_hsa003100.74568613
103RNA polymerase_Homo sapiens_hsa030200.71884945
104Calcium signaling pathway_Homo sapiens_hsa040200.69469593
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69310138
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68057324
107TGF-beta signaling pathway_Homo sapiens_hsa043500.67851088
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67724818
109Notch signaling pathway_Homo sapiens_hsa043300.67603608
110Viral carcinogenesis_Homo sapiens_hsa052030.66971627
111Regulation of autophagy_Homo sapiens_hsa041400.66851171
112VEGF signaling pathway_Homo sapiens_hsa043700.66733348
113Oxytocin signaling pathway_Homo sapiens_hsa049210.66427489
114Metabolic pathways_Homo sapiens_hsa011000.66013391
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65672225
116Nucleotide excision repair_Homo sapiens_hsa034200.65406843
117Alzheimers disease_Homo sapiens_hsa050100.65240484
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64907434
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.64680707
120Salivary secretion_Homo sapiens_hsa049700.64533014
121Oxidative phosphorylation_Homo sapiens_hsa001900.63904233
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63380622
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62605311
124Non-homologous end-joining_Homo sapiens_hsa034500.62433986
125p53 signaling pathway_Homo sapiens_hsa041150.62187324
126Protein export_Homo sapiens_hsa030600.62177658
127Fatty acid metabolism_Homo sapiens_hsa012120.61384598
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60994618
129Proteasome_Homo sapiens_hsa030500.60282352
130Folate biosynthesis_Homo sapiens_hsa007900.59666402
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59620525
132Arginine and proline metabolism_Homo sapiens_hsa003300.59596393
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58932325
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57704378
135Pyrimidine metabolism_Homo sapiens_hsa002400.55611376
136Pentose phosphate pathway_Homo sapiens_hsa000300.53722015
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53178264
138Non-small cell lung cancer_Homo sapiens_hsa052230.53113604
139Circadian rhythm_Homo sapiens_hsa047100.53042797
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52724129
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52375611
142GABAergic synapse_Homo sapiens_hsa047270.52054577
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52013461
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51069484
145Pyruvate metabolism_Homo sapiens_hsa006200.50864825
146HTLV-I infection_Homo sapiens_hsa051660.49770635
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49406440
148Fat digestion and absorption_Homo sapiens_hsa049750.48740751
149mTOR signaling pathway_Homo sapiens_hsa041500.48700487
150Fanconi anemia pathway_Homo sapiens_hsa034600.47879661
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45311621
152Tight junction_Homo sapiens_hsa045300.44405332
153Hedgehog signaling pathway_Homo sapiens_hsa043400.43500238
154Homologous recombination_Homo sapiens_hsa034400.42935401
155Carbon metabolism_Homo sapiens_hsa012000.42715516
156MAPK signaling pathway_Homo sapiens_hsa040100.42595910
157Wnt signaling pathway_Homo sapiens_hsa043100.41259619
158Selenocompound metabolism_Homo sapiens_hsa004500.40641025
159Basal cell carcinoma_Homo sapiens_hsa052170.39571955

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