TRIM48

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.77777246
2regulation of retinoic acid receptor signaling pathway (GO:0048385)6.35320750
3lateral sprouting from an epithelium (GO:0060601)6.31473076
4lysine metabolic process (GO:0006553)5.83413410
5lysine catabolic process (GO:0006554)5.83413410
6mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.27903510
7regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.96754353
8paraxial mesoderm development (GO:0048339)4.94182596
9planar cell polarity pathway involved in neural tube closure (GO:0090179)4.90385639
10notochord development (GO:0030903)4.71455906
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.64983575
12heterochromatin organization (GO:0070828)4.54199907
13cerebral cortex radially oriented cell migration (GO:0021799)4.41542210
14presynaptic membrane assembly (GO:0097105)4.30744606
15apical protein localization (GO:0045176)4.22274453
16establishment of nucleus localization (GO:0040023)4.16146256
17establishment of mitotic spindle localization (GO:0040001)4.07758074
18cardiovascular system development (GO:0072358)4.06106631
19establishment of mitotic spindle orientation (GO:0000132)4.03363492
20establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)4.02810391
21establishment of spindle orientation (GO:0051294)4.00694036
22histone-serine phosphorylation (GO:0035404)3.96422196
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.83747126
24convergent extension (GO:0060026)3.77211841
25pyrimidine nucleobase catabolic process (GO:0006208)3.75791598
26protein localization to kinetochore (GO:0034501)3.75000753
27chromosome condensation (GO:0030261)3.70122749
28post-anal tail morphogenesis (GO:0036342)3.69333812
29astrocyte development (GO:0014002)3.60934935
30establishment or maintenance of bipolar cell polarity (GO:0061245)3.60771781
31establishment or maintenance of apical/basal cell polarity (GO:0035088)3.60771781
32establishment of tissue polarity (GO:0007164)3.56507322
33establishment of planar polarity (GO:0001736)3.56507322
34establishment of spindle localization (GO:0051293)3.53978057
35outer ear morphogenesis (GO:0042473)3.52637855
36hindbrain development (GO:0030902)3.49799837
37aspartate family amino acid catabolic process (GO:0009068)3.47136928
38histone H3-K9 demethylation (GO:0033169)3.45256542
39presynaptic membrane organization (GO:0097090)3.43637722
40nonmotile primary cilium assembly (GO:0035058)3.42556236
41thalamus development (GO:0021794)3.41903392
42tryptophan metabolic process (GO:0006568)3.40915295
43mitotic chromosome condensation (GO:0007076)3.40726970
44linoleic acid metabolic process (GO:0043651)3.40476528
45negative regulation of chondrocyte differentiation (GO:0032331)3.40377894
46mitotic sister chromatid segregation (GO:0000070)3.39743156
47dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.39590901
48regulation of stem cell maintenance (GO:2000036)3.38184890
49cell migration in hindbrain (GO:0021535)3.36585450
50mitotic cytokinesis (GO:0000281)3.33335571
51lymph vessel development (GO:0001945)3.32376845
52protein localization to chromosome, centromeric region (GO:0071459)3.26030229
53sister chromatid segregation (GO:0000819)3.20994248
54Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.19062404
55embryonic camera-type eye development (GO:0031076)3.18343969
56axon extension involved in axon guidance (GO:0048846)3.16685669
57neuron projection extension involved in neuron projection guidance (GO:1902284)3.16685669
58regulation of establishment of planar polarity (GO:0090175)3.11049114
59regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.09308145
60DNA unwinding involved in DNA replication (GO:0006268)3.07993199
61limb bud formation (GO:0060174)3.07747859
62pituitary gland development (GO:0021983)3.07304978
63cell proliferation in forebrain (GO:0021846)3.06875161
64postsynaptic membrane organization (GO:0001941)3.02834800
65embryonic digestive tract development (GO:0048566)3.02178630
66meiotic chromosome segregation (GO:0045132)3.01076508
67negative regulation of DNA repair (GO:0045738)2.98414383
68nucleus localization (GO:0051647)2.95850823
69alpha-linolenic acid metabolic process (GO:0036109)2.91995542
70regulation of spindle organization (GO:0090224)2.89861463
71chondrocyte proliferation (GO:0035988)2.89529025
72DNA packaging (GO:0006323)2.88143158
73lateral ventricle development (GO:0021670)2.87317508
74mesenchymal to epithelial transition (GO:0060231)2.84538640
75cytoskeleton-dependent cytokinesis (GO:0061640)2.81806345
76negative regulation by host of viral transcription (GO:0043922)2.78455052
77triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.77490290
78regulation of cellular senescence (GO:2000772)2.76759612
79kidney morphogenesis (GO:0060993)2.74763127
80respiratory tube development (GO:0030323)2.74427674
81cochlea morphogenesis (GO:0090103)2.73512715
82nucleobase catabolic process (GO:0046113)2.72261564
83regulation of posttranscriptional gene silencing (GO:0060147)2.70080708
84regulation of gene silencing by miRNA (GO:0060964)2.70080708
85regulation of gene silencing by RNA (GO:0060966)2.70080708
86developmental induction (GO:0031128)2.68003949
87asymmetric protein localization (GO:0008105)2.67952644
88plasma membrane repair (GO:0001778)2.67406219
89ventricular cardiac muscle cell development (GO:0055015)2.65565705
90inner ear receptor stereocilium organization (GO:0060122)2.65498075
91metaphase plate congression (GO:0051310)2.64978360
92protein localization to chromosome (GO:0034502)2.61871265
93mitotic metaphase plate congression (GO:0007080)2.61845315
94cell wall macromolecule metabolic process (GO:0044036)2.60683805
95neuronal stem cell maintenance (GO:0097150)2.59466255
96regulation of centriole replication (GO:0046599)2.59054121
97cell-cell signaling involved in cell fate commitment (GO:0045168)2.57931611
98cerebral cortex cell migration (GO:0021795)2.57509376
99spindle assembly (GO:0051225)2.56927892
100G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.55984949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.84007723
2E2F7_22180533_ChIP-Seq_HELA_Human4.14999363
3EZH2_22144423_ChIP-Seq_EOC_Human3.79858826
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.72652556
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.60034252
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28230602
7* IGF1R_20145208_ChIP-Seq_DFB_Human2.98088849
8VDR_22108803_ChIP-Seq_LS180_Human2.90334088
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.84541400
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78223592
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.74236651
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45899320
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.37549642
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.37549642
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.37549642
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27666765
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21529462
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19105475
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03817219
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97623431
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97359246
22* AR_21909140_ChIP-Seq_LNCAP_Human1.78091180
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72744857
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70284808
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60874445
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56932404
27KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.56524799
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.56373996
29SOX9_26525672_Chip-Seq_HEART_Mouse1.52654010
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50226347
31SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50156176
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49119032
33ZNF274_21170338_ChIP-Seq_K562_Hela1.43185095
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42584723
35ISL1_27105846_Chip-Seq_CPCs_Mouse1.40895722
36POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38960714
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38378340
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37253136
39IRF1_19129219_ChIP-ChIP_H3396_Human1.36598392
40* AR_21572438_ChIP-Seq_LNCaP_Human1.34019186
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33797743
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27367212
43OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27291750
44* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27191298
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.20879747
46STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19636501
47GBX2_23144817_ChIP-Seq_PC3_Human1.18682474
48POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.16847721
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16461024
50SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.15384657
51TAF15_26573619_Chip-Seq_HEK293_Human1.14982684
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.13965119
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13493230
54CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13466593
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13313121
56LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13181649
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12792503
58TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12677243
59TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10971983
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10631316
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.10623653
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09150858
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08776579
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07909555
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07015336
66YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06197373
67TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04304972
68NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03262837
69POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02501722
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01479262
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01446214
72MYC_18940864_ChIP-ChIP_HL60_Human0.99243677
73* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98874985
74NANOG_21062744_ChIP-ChIP_HESCs_Human0.98864035
75POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97726329
76ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97633437
77ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96263720
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95775611
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94403557
80STAT3_23295773_ChIP-Seq_U87_Human0.94075957
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90873796
82EED_16625203_ChIP-ChIP_MESCs_Mouse0.90172973
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89883636
84REST_18959480_ChIP-ChIP_MESCs_Mouse0.89419879
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88454548
86RNF2_27304074_Chip-Seq_NSC_Mouse0.88231370
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88068537
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87495830
89NANOG_16153702_ChIP-ChIP_HESCs_Human0.86981832
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85775427
91TP53_18474530_ChIP-ChIP_U2OS_Human0.85567267
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85474441
93CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85469630
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84547602
95TP63_19390658_ChIP-ChIP_HaCaT_Human0.83235419
96TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.83074006
97* SMAD4_21799915_ChIP-Seq_A2780_Human0.83039201
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.81921045
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.81697318
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81142102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009053_abnormal_anal_canal4.53357085
2MP0006292_abnormal_olfactory_placode3.87131036
3MP0002089_abnormal_postnatal_growth/wei2.97537982
4MP0003119_abnormal_digestive_system2.84400474
5MP0003136_yellow_coat_color2.83468974
6MP0002653_abnormal_ependyma_morphology2.54014411
7MP0003122_maternal_imprinting2.41158118
8MP0004272_abnormal_basement_membrane2.39751502
9MP0005257_abnormal_intraocular_pressure2.37769803
10MP0010368_abnormal_lymphatic_system2.23015382
11MP0000778_abnormal_nervous_system2.17400916
12MP0005248_abnormal_Harderian_gland2.04708813
13MP0009697_abnormal_copulation2.04061418
14MP0000537_abnormal_urethra_morphology2.00490888
15MP0003938_abnormal_ear_development1.97233942
16MP0003705_abnormal_hypodermis_morpholog1.95667623
17MP0005623_abnormal_meninges_morphology1.95378920
18MP0003121_genomic_imprinting1.94251678
19MP0001293_anophthalmia1.93999011
20MP0004858_abnormal_nervous_system1.93019009
21MP0008057_abnormal_DNA_replication1.88212486
22MP0001849_ear_inflammation1.87866338
23MP0000534_abnormal_ureter_morphology1.85101543
24MP0003693_abnormal_embryo_hatching1.78798495
25MP0010094_abnormal_chromosome_stability1.77140394
26MP0003942_abnormal_urinary_system1.74141461
27MP0003111_abnormal_nucleus_morphology1.73882046
28MP0000569_abnormal_digit_pigmentation1.73815852
29MP0001299_abnormal_eye_distance/1.66986613
30MP0008932_abnormal_embryonic_tissue1.65683813
31MP0002697_abnormal_eye_size1.62970300
32MP0003937_abnormal_limbs/digits/tail_de1.61858860
33MP0001879_abnormal_lymphatic_vessel1.54888046
34MP0000049_abnormal_middle_ear1.54110687
35MP0003861_abnormal_nervous_system1.48155250
36MP0005187_abnormal_penis_morphology1.48152874
37MP0002009_preneoplasia1.42205388
38MP0003077_abnormal_cell_cycle1.40929783
39MP0002111_abnormal_tail_morphology1.40025279
40MP0009672_abnormal_birth_weight1.34971175
41MP0000955_abnormal_spinal_cord1.30397050
42MP0001286_abnormal_eye_development1.28381026
43MP0002085_abnormal_embryonic_tissue1.26080070
44MP0000566_synostosis1.23741636
45MP0005380_embryogenesis_phenotype1.22629914
46MP0001672_abnormal_embryogenesis/_devel1.22629914
47MP0004885_abnormal_endolymph1.21602127
48MP0003890_abnormal_embryonic-extraembry1.21122341
49MP0003385_abnormal_body_wall1.20825866
50MP0001915_intracranial_hemorrhage1.19702281
51MP0005423_abnormal_somatic_nervous1.17040706
52MP0002084_abnormal_developmental_patter1.16577443
53MP0008007_abnormal_cellular_replicative1.15985504
54MP0000647_abnormal_sebaceous_gland1.14250341
55MP0004130_abnormal_muscle_cell1.13577455
56MP0002184_abnormal_innervation1.08751249
57MP0002938_white_spotting1.08580953
58MP0006054_spinal_hemorrhage1.07833614
59MP0002233_abnormal_nose_morphology1.07743140
60MP0003755_abnormal_palate_morphology1.06524360
61MP0002152_abnormal_brain_morphology1.03778083
62MP0008058_abnormal_DNA_repair1.03399526
63MP0004197_abnormal_fetal_growth/weight/1.03389431
64MP0003300_gastrointestinal_ulcer1.01377304
65MP0003283_abnormal_digestive_organ0.97556261
66MP0010030_abnormal_orbit_morphology0.96432893
67MP0002092_abnormal_eye_morphology0.94848764
68MP0002557_abnormal_social/conspecific_i0.93734286
69MP0006072_abnormal_retinal_apoptosis0.92370857
70MP0003935_abnormal_craniofacial_develop0.92239026
71MP0002081_perinatal_lethality0.89423547
72MP0001929_abnormal_gametogenesis0.89018786
73MP0000428_abnormal_craniofacial_morphol0.88451992
74MP0000432_abnormal_head_morphology0.88006646
75MP0003984_embryonic_growth_retardation0.87497290
76MP0009250_abnormal_appendicular_skeleto0.86899935
77MP0002210_abnormal_sex_determination0.85453324
78MP0000631_abnormal_neuroendocrine_gland0.85163602
79MP0002736_abnormal_nociception_after0.84362582
80MP0000350_abnormal_cell_proliferation0.83980873
81MP0005367_renal/urinary_system_phenotyp0.83616475
82MP0000516_abnormal_urinary_system0.83616475
83MP0003123_paternal_imprinting0.82899281
84MP0009384_cardiac_valve_regurgitation0.82877495
85MP0009703_decreased_birth_body0.82844803
86MP0000579_abnormal_nail_morphology0.82120937
87MP0002088_abnormal_embryonic_growth/wei0.82084482
88MP0000026_abnormal_inner_ear0.81952723
89MP0003567_abnormal_fetal_cardiomyocyte0.81881660
90MP0003698_abnormal_male_reproductive0.81848029
91MP0001697_abnormal_embryo_size0.81753007
92MP0004859_abnormal_synaptic_plasticity0.81669854
93MP0001919_abnormal_reproductive_system0.81042447
94MP0004233_abnormal_muscle_weight0.80382755
95MP0002116_abnormal_craniofacial_bone0.80123168
96MP0005171_absent_coat_pigmentation0.78674798
97MP0001529_abnormal_vocalization0.76995340
98MP0002882_abnormal_neuron_morphology0.76710604
99MP0000750_abnormal_muscle_regeneration0.76029927
100MP0003115_abnormal_respiratory_system0.75467249

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the ischium (HP:0003174)4.91600479
2Hypoplastic ischia (HP:0003175)4.49779801
3Cortical dysplasia (HP:0002539)4.01348936
4Spastic diplegia (HP:0001264)3.90071134
5Vitreoretinal degeneration (HP:0000655)3.79880424
6Short 4th metacarpal (HP:0010044)3.74281666
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.74281666
8Partial duplication of thumb phalanx (HP:0009944)3.65320684
9Thin ribs (HP:0000883)3.48070279
10Hypoplastic pelvis (HP:0008839)3.46012736
11Metaphyseal cupping (HP:0003021)3.27836700
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.23930595
13Trigonocephaly (HP:0000243)3.23806230
14Preaxial foot polydactyly (HP:0001841)3.16216690
15Flat capital femoral epiphysis (HP:0003370)3.11905927
16Epidermoid cyst (HP:0200040)3.09947484
17Partial duplication of the phalanx of hand (HP:0009999)3.07538249
18High anterior hairline (HP:0009890)2.95637420
19Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.94174172
20Absent epiphyses (HP:0010577)2.94174172
21Abnormality of the 4th metacarpal (HP:0010012)2.78410504
22Duplication of thumb phalanx (HP:0009942)2.77655927
23Atonic seizures (HP:0010819)2.67824138
24Broad thumb (HP:0011304)2.66975636
25Intestinal atresia (HP:0011100)2.66237700
26Irregular epiphyses (HP:0010582)2.58410718
27Septo-optic dysplasia (HP:0100842)2.58123967
28Flattened epiphyses (HP:0003071)2.53152302
29Broad metatarsal (HP:0001783)2.52905986
30Abnormality of the diencephalon (HP:0010662)2.40574020
31Hepatoblastoma (HP:0002884)2.33381735
32Colon cancer (HP:0003003)2.33155533
33Abnormality of the calcaneus (HP:0008364)2.28728249
34Abnormality of lateral ventricle (HP:0030047)2.22870782
35Partial agenesis of the corpus callosum (HP:0001338)2.21447578
36Broad phalanges of the hand (HP:0009768)2.19321296
37Camptodactyly of toe (HP:0001836)2.17869665
38Ectopic kidney (HP:0000086)2.14256144
39Prominent supraorbital ridges (HP:0000336)2.13161558
40Rib fusion (HP:0000902)2.11074018
41Enlarged penis (HP:0000040)2.10943381
42Hyperlipoproteinemia (HP:0010980)2.10846055
43Rectovaginal fistula (HP:0000143)2.09484251
44Rectal fistula (HP:0100590)2.09484251
45Coronal craniosynostosis (HP:0004440)2.09367668
46Vertebral clefting (HP:0008428)2.03465313
47Broad finger (HP:0001500)2.02498225
48Skin nodule (HP:0200036)2.02135532
49Hypoplastic iliac wings (HP:0002866)2.01453684
50Urethral obstruction (HP:0000796)2.00301470
51Cupped ribs (HP:0000887)2.00010060
52Arthropathy (HP:0003040)2.00001544
53Birth length less than 3rd percentile (HP:0003561)1.99713986
54Broad phalanx (HP:0006009)1.99184222
55Meckel diverticulum (HP:0002245)1.96473825
56Abnormality of the metopic suture (HP:0005556)1.95992588
57Abnormality of the proximal phalanges of the hand (HP:0009834)1.95425056
58Hypoplasia of the ulna (HP:0003022)1.95184972
59Poor head control (HP:0002421)1.95141662
60Gastrointestinal atresia (HP:0002589)1.93546836
61Broad palm (HP:0001169)1.93509618
62Elfin facies (HP:0004428)1.93053870
63Triphalangeal thumb (HP:0001199)1.92186043
64Hyperacusis (HP:0010780)1.91827911
65Neoplasm of the peripheral nervous system (HP:0100007)1.91788328
66Missing ribs (HP:0000921)1.90453898
67Arnold-Chiari malformation (HP:0002308)1.88916447
68Thoracolumbar scoliosis (HP:0002944)1.86777465
6911 pairs of ribs (HP:0000878)1.85475626
70Abnormality of the ileum (HP:0001549)1.85474503
71Aqueductal stenosis (HP:0002410)1.84167121
72Renovascular hypertension (HP:0100817)1.83853586
73Abnormality of the carotid arteries (HP:0005344)1.83683248
74Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82123398
75Megalocornea (HP:0000485)1.81637564
76Abnormality of incisor morphology (HP:0011063)1.80917737
77Cutaneous finger syndactyly (HP:0010554)1.80891863
78Overlapping toe (HP:0001845)1.80482139
79Large eyes (HP:0001090)1.78152411
80Abnormality of the pubic bones (HP:0003172)1.77426490
81Renal hypoplasia (HP:0000089)1.76697827
82Split foot (HP:0001839)1.76142465
83Absent septum pellucidum (HP:0001331)1.75684087
84Intestinal fistula (HP:0100819)1.72695675
85Broad long bones (HP:0005622)1.72019467
86Squamous cell carcinoma (HP:0002860)1.71886888
87Midline defect of the nose (HP:0004122)1.71824473
88Myelomeningocele (HP:0002475)1.71412902
89Pseudobulbar signs (HP:0002200)1.70680404
90Patellar aplasia (HP:0006443)1.70543895
91Hypoplastic ilia (HP:0000946)1.69636296
92Flared metaphyses (HP:0003015)1.69138496
93Long clavicles (HP:0000890)1.67999502
94Attenuation of retinal blood vessels (HP:0007843)1.67956417
95Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.67787744
96Vertebral hypoplasia (HP:0008417)1.67787744
97Vaginal fistula (HP:0004320)1.67599648
98Optic nerve hypoplasia (HP:0000609)1.67021129
99Overriding aorta (HP:0002623)1.67010517
100Absence seizures (HP:0002121)1.66738425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.77779046
2TYRO33.36604708
3MKNK23.19045047
4EPHA33.01296430
5MKNK12.72419566
6STK38L2.28055624
7FRK2.12294320
8MARK12.09791218
9MOS2.03385855
10TNIK1.92754120
11WEE11.91305227
12PAK61.90304718
13LATS21.88822744
14NTRK21.83535487
15MAP3K101.81604940
16PRKD31.70084165
17TRIB31.66545665
18KDR1.65596871
19CDC71.61967534
20ICK1.55344870
21PTK61.51286868
22UHMK11.50064892
23NTRK11.49530116
24PDK21.43673443
25FGFR21.43088218
26CHEK21.38140002
27MAP2K71.34185142
28MAP3K91.34084915
29ERBB41.30961485
30BRSK21.27967837
31NEK21.26523933
32MET1.24653356
33PDGFRA1.21973111
34EPHA21.20962592
35PLK21.18962834
36LIMK11.18875292
37PASK1.18829985
38TTK1.18142942
39BUB11.15657946
40CDK151.15178301
41CDK181.13468244
42CDK11A1.11029762
43BMX1.10676153
44NEK91.06433172
45PLK11.03188998
46CDK141.01234323
47NEK60.96052115
48TESK20.95641974
49CDK60.94405523
50CDK190.94385454
51DYRK20.94199560
52PNCK0.92604413
53BRD40.91420864
54CASK0.90385780
55STK160.89422615
56CAMK1G0.83282785
57PDGFRB0.82637626
58NEK10.81709167
59BRSK10.81648194
60SRPK10.81438170
61PLK30.78238147
62CAMK1D0.73598157
63PTK20.72193028
64CDK120.70446325
65PLK40.70148885
66KSR10.69452463
67LATS10.67011579
68CSNK1G30.64990767
69STK30.64888533
70ATR0.64869618
71CSNK1A1L0.64254430
72MAP2K60.64032382
73MAP3K40.63084089
74FGR0.60452395
75PTK2B0.60120647
76PRKCG0.59253210
77CHEK10.58219549
78CSNK1G10.58155619
79CSF1R0.56449334
80TGFBR10.55976139
81MARK30.55068725
82MTOR0.54308092
83PAK20.53977230
84RET0.53333438
85KSR20.52235935
86BCR0.51648200
87CDK80.49007350
88STK240.48126061
89CDK40.46747119
90CDK70.46333751
91YES10.43746145
92CDK10.42779934
93CSNK1D0.42608300
94FGFR10.38997837
95DYRK1A0.37986009
96CSNK1G20.37794892
97ROCK20.36513358
98AURKA0.35485760
99CDK20.34583416
100PRKCZ0.32463665

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.43833807
2Steroid biosynthesis_Homo sapiens_hsa001002.99638391
3Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.60538579
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.52576651
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25651351
6Selenocompound metabolism_Homo sapiens_hsa004502.08624689
7Basal cell carcinoma_Homo sapiens_hsa052172.06917553
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06755594
9Butanoate metabolism_Homo sapiens_hsa006502.06487712
10Axon guidance_Homo sapiens_hsa043602.05433764
11Non-homologous end-joining_Homo sapiens_hsa034502.04704933
12Tryptophan metabolism_Homo sapiens_hsa003802.02411081
13Cell cycle_Homo sapiens_hsa041101.98723734
14Hippo signaling pathway_Homo sapiens_hsa043901.95935176
15Lysine degradation_Homo sapiens_hsa003101.93217160
16DNA replication_Homo sapiens_hsa030301.80197846
17mRNA surveillance pathway_Homo sapiens_hsa030151.71437550
18Fanconi anemia pathway_Homo sapiens_hsa034601.69593846
19Hedgehog signaling pathway_Homo sapiens_hsa043401.64182122
20Prion diseases_Homo sapiens_hsa050201.64136938
21Adherens junction_Homo sapiens_hsa045201.54828301
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.53239092
23Fatty acid metabolism_Homo sapiens_hsa012121.51112089
24MicroRNAs in cancer_Homo sapiens_hsa052061.48448035
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48306338
26p53 signaling pathway_Homo sapiens_hsa041151.45542110
27Nucleotide excision repair_Homo sapiens_hsa034201.40687495
28Basal transcription factors_Homo sapiens_hsa030221.31345283
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30187219
30Colorectal cancer_Homo sapiens_hsa052101.29422484
31Homologous recombination_Homo sapiens_hsa034401.25222239
32Oocyte meiosis_Homo sapiens_hsa041141.23495914
33Wnt signaling pathway_Homo sapiens_hsa043101.23377295
34One carbon pool by folate_Homo sapiens_hsa006701.18377789
35Base excision repair_Homo sapiens_hsa034101.18298741
36Olfactory transduction_Homo sapiens_hsa047401.16787906
37Focal adhesion_Homo sapiens_hsa045101.16093032
38RNA transport_Homo sapiens_hsa030131.15710246
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14975500
40Tight junction_Homo sapiens_hsa045301.14604084
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13457943
42Notch signaling pathway_Homo sapiens_hsa043301.04891550
43ECM-receptor interaction_Homo sapiens_hsa045121.04835422
44Phototransduction_Homo sapiens_hsa047441.02141078
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01894903
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01543644
47Melanoma_Homo sapiens_hsa052180.94641179
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93055385
49Glycerolipid metabolism_Homo sapiens_hsa005610.91853769
50Mismatch repair_Homo sapiens_hsa034300.90914489
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87970407
52ErbB signaling pathway_Homo sapiens_hsa040120.87858848
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87300188
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85910405
55Dopaminergic synapse_Homo sapiens_hsa047280.84877436
56Spliceosome_Homo sapiens_hsa030400.84433491
57Glioma_Homo sapiens_hsa052140.81026872
58Small cell lung cancer_Homo sapiens_hsa052220.80286823
59Glutamatergic synapse_Homo sapiens_hsa047240.77891536
60PPAR signaling pathway_Homo sapiens_hsa033200.73194349
61Taste transduction_Homo sapiens_hsa047420.71439503
62Gap junction_Homo sapiens_hsa045400.70540118
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70008806
64Prostate cancer_Homo sapiens_hsa052150.69249884
65Bile secretion_Homo sapiens_hsa049760.65878818
66Ras signaling pathway_Homo sapiens_hsa040140.65785982
67Pathways in cancer_Homo sapiens_hsa052000.65301304
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65045864
69Circadian entrainment_Homo sapiens_hsa047130.64676315
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64092497
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61854008
72Nitrogen metabolism_Homo sapiens_hsa009100.61604423
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.61592251
74Linoleic acid metabolism_Homo sapiens_hsa005910.61505611
75Cholinergic synapse_Homo sapiens_hsa047250.60931968
76Rap1 signaling pathway_Homo sapiens_hsa040150.60862543
77Inositol phosphate metabolism_Homo sapiens_hsa005620.60179965
78Fatty acid degradation_Homo sapiens_hsa000710.59782926
79Nicotine addiction_Homo sapiens_hsa050330.59312442
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59205966
81Choline metabolism in cancer_Homo sapiens_hsa052310.57893960
82Vibrio cholerae infection_Homo sapiens_hsa051100.55035171
83Renal cell carcinoma_Homo sapiens_hsa052110.54482254
84Estrogen signaling pathway_Homo sapiens_hsa049150.52756831
85Cocaine addiction_Homo sapiens_hsa050300.52677922
86Fatty acid biosynthesis_Homo sapiens_hsa000610.51481338
87Morphine addiction_Homo sapiens_hsa050320.50927122
88N-Glycan biosynthesis_Homo sapiens_hsa005100.50314468
89Endometrial cancer_Homo sapiens_hsa052130.49124457
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.45729318
91Long-term depression_Homo sapiens_hsa047300.44278663
92Melanogenesis_Homo sapiens_hsa049160.43572726
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.42670952
94VEGF signaling pathway_Homo sapiens_hsa043700.41731387
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41690716
96RNA degradation_Homo sapiens_hsa030180.41600848
97GABAergic synapse_Homo sapiens_hsa047270.38446001
98Fat digestion and absorption_Homo sapiens_hsa049750.37873216
99Prolactin signaling pathway_Homo sapiens_hsa049170.36840729
100Ovarian steroidogenesis_Homo sapiens_hsa049130.31375655

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