TRIM49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oocyte development (GO:0048599)7.66763257
2positive regulation of catecholamine secretion (GO:0033605)6.87449587
3multicellular organism reproduction (GO:0032504)6.72012582
4regulation of RIG-I signaling pathway (GO:0039535)6.64503262
5regulation of female gonad development (GO:2000194)6.32956849
6regulation of acrosome reaction (GO:0060046)5.97600024
7positive regulation of meiosis (GO:0045836)5.97322778
8synaptonemal complex organization (GO:0070193)5.88343706
9histone lysine demethylation (GO:0070076)5.83717932
10regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)5.81220872
11synaptonemal complex assembly (GO:0007130)5.78429372
12regulation of exit from mitosis (GO:0007096)5.69441077
13positive regulation of meiotic cell cycle (GO:0051446)5.69096460
14positive regulation of uterine smooth muscle contraction (GO:0070474)5.58901487
15histone demethylation (GO:0016577)5.57696476
16protein dealkylation (GO:0008214)4.96183076
17protein demethylation (GO:0006482)4.96183076
18gonadal mesoderm development (GO:0007506)4.89069196
19single fertilization (GO:0007338)4.71177261
20regulation of female receptivity (GO:0045924)4.68807762
21male meiosis I (GO:0007141)4.50236615
22negative regulation of Ras GTPase activity (GO:0034261)4.44011757
23binding of sperm to zona pellucida (GO:0007339)4.42911463
24reproduction (GO:0000003)4.35001941
25regulation of uterine smooth muscle contraction (GO:0070472)4.24522878
26N-terminal protein amino acid acetylation (GO:0006474)4.18870456
27regulation of cytokine production involved in inflammatory response (GO:1900015)4.18020050
28meiotic cell cycle (GO:0051321)4.17241173
29regulation of alternative mRNA splicing, via spliceosome (GO:0000381)4.15269160
30aggressive behavior (GO:0002118)4.02145327
31sleep (GO:0030431)3.93950348
32chromosome organization involved in meiosis (GO:0070192)3.93308394
33negative regulation of digestive system process (GO:0060457)3.93047986
34female mating behavior (GO:0060180)3.91924365
35positive regulation of prostaglandin secretion (GO:0032308)3.91396712
36protein K48-linked deubiquitination (GO:0071108)3.89314283
37drinking behavior (GO:0042756)3.78536365
38positive regulation of digestive system process (GO:0060456)3.78022724
39positive regulation of histone H3-K4 methylation (GO:0051571)3.77010765
40regulation of penile erection (GO:0060405)3.74192883
41sperm-egg recognition (GO:0035036)3.73254692
42piRNA metabolic process (GO:0034587)3.70488619
43glycine transport (GO:0015816)3.70289792
44parental behavior (GO:0060746)3.67316778
45fertilization (GO:0009566)3.66370980
46acrosome reaction (GO:0007340)3.59009910
47negative regulation of reproductive process (GO:2000242)3.58442277
48centriole replication (GO:0007099)3.52528459
49regulation of meiosis (GO:0040020)3.46690802
50maternal behavior (GO:0042711)3.46243789
51male meiosis (GO:0007140)3.42856583
52hyperosmotic salinity response (GO:0042538)3.41378086
53negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.40384626
54meiosis I (GO:0007127)3.39875549
55negative regulation of smooth muscle cell differentiation (GO:0051151)3.35958155
56protein kinase C signaling (GO:0070528)3.27085580
57retinal cone cell development (GO:0046549)3.26070166
58protein K63-linked deubiquitination (GO:0070536)3.18349857
59regulation of DNA methylation (GO:0044030)3.11253850
60response to prostaglandin (GO:0034694)3.10565277
61regulation of protein polyubiquitination (GO:1902914)3.10277219
62regulation of prostaglandin secretion (GO:0032306)3.09661536
63calcium ion-dependent exocytosis (GO:0017156)3.05144136
64regulation of meiotic cell cycle (GO:0051445)3.01834227
65response to UV-C (GO:0010225)2.97503552
66regulation of helicase activity (GO:0051095)2.93764859
67cell-cell recognition (GO:0009988)2.92143803
68poly(A)+ mRNA export from nucleus (GO:0016973)2.91892553
69regulation of histone H3-K9 methylation (GO:0051570)2.90818859
70positive regulation of humoral immune response (GO:0002922)2.90508116
71protein K6-linked ubiquitination (GO:0085020)2.89375379
72regulation of mRNA splicing, via spliceosome (GO:0048024)2.89306470
73positive regulation of reproductive process (GO:2000243)2.86829164
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.81733874
75cochlea development (GO:0090102)2.81363351
76response to prostaglandin E (GO:0034695)2.81329737
77meiotic cell cycle process (GO:1903046)2.72031776
78gamma-aminobutyric acid signaling pathway (GO:0007214)2.71359113
79regulation of ruffle assembly (GO:1900027)2.68294032
80histone mRNA catabolic process (GO:0071044)2.66119290
81citrulline biosynthetic process (GO:0019240)2.65080776
82epithelial cilium movement (GO:0003351)2.63809721
83DNA replication-dependent nucleosome organization (GO:0034723)2.63747405
84DNA replication-dependent nucleosome assembly (GO:0006335)2.63747405
85positive regulation of gastrulation (GO:2000543)2.62006803
86regulation of DNA endoreduplication (GO:0032875)2.60274312
87positive regulation of amine transport (GO:0051954)2.60216624
88regulation of defense response to virus by host (GO:0050691)2.59773749
89mitochondrion morphogenesis (GO:0070584)2.58523605
90demethylation (GO:0070988)2.57007716
91positive regulation of fatty acid transport (GO:2000193)2.55878534
92maturation of SSU-rRNA (GO:0030490)2.55024454
93regulation of posttranscriptional gene silencing (GO:0060147)2.53427264
94regulation of gene silencing by miRNA (GO:0060964)2.53427264
95regulation of gene silencing by RNA (GO:0060966)2.53427264
96tryptophan catabolic process (GO:0006569)2.52960766
97indolalkylamine catabolic process (GO:0046218)2.52960766
98histone H3-K9 demethylation (GO:0033169)14.9380888
99negative regulation of retinoic acid receptor signaling pathway (GO:0048387)13.7625238
100regulation of retinoic acid receptor signaling pathway (GO:0048385)11.4145271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.65780364
2EZH2_22144423_ChIP-Seq_EOC_Human6.74342296
3GBX2_23144817_ChIP-Seq_PC3_Human4.04266718
4VDR_22108803_ChIP-Seq_LS180_Human3.77935123
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.38524516
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.27034254
7NOTCH1_21737748_ChIP-Seq_TLL_Human3.21802135
8IGF1R_20145208_ChIP-Seq_DFB_Human2.75807513
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40473291
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32770714
11ZNF274_21170338_ChIP-Seq_K562_Hela2.21193802
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05774004
13PRDM14_20953172_ChIP-Seq_ESCs_Human1.95210874
14IRF1_19129219_ChIP-ChIP_H3396_Human1.92972979
15TP63_19390658_ChIP-ChIP_HaCaT_Human1.88065430
16TOP2B_26459242_ChIP-Seq_MCF-7_Human1.87767972
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84826932
18RXR_22108803_ChIP-Seq_LS180_Human1.83580253
19MYC_18940864_ChIP-ChIP_HL60_Human1.79157508
20TCF4_23295773_ChIP-Seq_U87_Human1.77349627
21AR_25329375_ChIP-Seq_VCAP_Human1.74391158
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74273315
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.70260517
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.70260517
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.70260517
26CBP_21632823_ChIP-Seq_H3396_Human1.66517738
27TAF15_26573619_Chip-Seq_HEK293_Human1.66114086
28SMAD3_21741376_ChIP-Seq_HESCs_Human1.63543172
29AUTS2_25519132_ChIP-Seq_293T-REX_Human1.62593033
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62534839
31RNF2_27304074_Chip-Seq_NSC_Mouse1.61178821
32SMAD4_21799915_ChIP-Seq_A2780_Human1.60019571
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59262841
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56956372
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55455999
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53707186
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52287863
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51883168
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51875545
40STAT3_23295773_ChIP-Seq_U87_Human1.51862434
41P300_19829295_ChIP-Seq_ESCs_Human1.46399992
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.44572193
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42870470
44TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.41463597
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36670815
46SMAD4_21741376_ChIP-Seq_EPCs_Human1.35148207
47NCOR_22424771_ChIP-Seq_293T_Human1.31559722
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.30974172
49RAC3_21632823_ChIP-Seq_H3396_Human1.30542945
50BCAT_22108803_ChIP-Seq_LS180_Human1.30516648
51RUNX2_22187159_ChIP-Seq_PCA_Human1.28953309
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28072629
53SMRT_27268052_Chip-Seq_Bcells_Human1.27534187
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26370183
55SMAD4_21741376_ChIP-Seq_HESCs_Human1.26163911
56FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24357499
57STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.24329149
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21661217
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.21297416
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20080509
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19946932
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19776779
63TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16844099
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16318682
65KDM2B_26808549_Chip-Seq_REH_Human1.16110863
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14396733
67GATA3_26560356_Chip-Seq_TH1_Human1.13711692
68TCF4_22108803_ChIP-Seq_LS180_Human1.13387658
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13245161
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.11923743
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09915284
72SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.08905726
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07880414
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04421394
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.04251948
76TP53_22573176_ChIP-Seq_HFKS_Human1.01694852
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01381016
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01176528
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96404426
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96331029
81REST_21632747_ChIP-Seq_MESCs_Mouse0.95841433
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95355441
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95084153
84TAF2_19829295_ChIP-Seq_ESCs_Human0.94700726
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93749237
86KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92316638
87KLF4_19829295_ChIP-Seq_ESCs_Human0.92072570
88FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91919355
89SOX2_16153702_ChIP-ChIP_HESCs_Human0.91503130
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88187952
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87061233
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85716154
93CBX2_27304074_Chip-Seq_ESCs_Mouse0.85424504
94AR_21572438_ChIP-Seq_LNCaP_Human0.84121941
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83631876
96NANOG_20526341_ChIP-Seq_ESCs_Human0.83367437
97* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82761810
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82704409
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82501573
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82493493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.75197313
2MP0009379_abnormal_foot_pigmentation4.22180167
3MP0003283_abnormal_digestive_organ3.50909200
4MP0003890_abnormal_embryonic-extraembry3.28329853
5MP0003693_abnormal_embryo_hatching3.16867606
6MP0005410_abnormal_fertilization3.01493048
7MP0003950_abnormal_plasma_membrane2.97436300
8MP0003718_maternal_effect2.94444866
9MP0008058_abnormal_DNA_repair2.92900428
10MP0000678_abnormal_parathyroid_gland2.84764193
11MP0008877_abnormal_DNA_methylation2.66223401
12MP0006276_abnormal_autonomic_nervous2.65737414
13MP0002160_abnormal_reproductive_system2.60005615
14MP0000427_abnormal_hair_cycle2.50806538
15MP0001502_abnormal_circadian_rhythm2.42407167
16MP0001664_abnormal_digestion2.33346339
17MP0009840_abnormal_foam_cell2.33038198
18MP0003136_yellow_coat_color2.29952422
19MP0001929_abnormal_gametogenesis2.29228601
20MP0003119_abnormal_digestive_system2.14413608
21MP0003699_abnormal_female_reproductive2.04325040
22MP0002210_abnormal_sex_determination1.99771422
23MP0005646_abnormal_pituitary_gland1.73787428
24MP0003866_abnormal_defecation1.62422811
25MP0005360_urolithiasis1.60940763
26MP0002751_abnormal_autonomic_nervous1.57336651
27MP0000049_abnormal_middle_ear1.50674520
28MP0001666_abnormal_nutrient_absorption1.45997059
29MP0002127_abnormal_cardiovascular_syste1.41756659
30MP0004043_abnormal_pH_regulation1.41443182
31MP0005389_reproductive_system_phenotype1.41304232
32MP0000653_abnormal_sex_gland1.40296358
33MP0003121_genomic_imprinting1.39916195
34MP0006072_abnormal_retinal_apoptosis1.34052578
35MP0003698_abnormal_male_reproductive1.32587661
36MP0003868_abnormal_feces_composition1.32586723
37MP0002161_abnormal_fertility/fecundity1.26502272
38MP0002277_abnormal_respiratory_mucosa1.25131198
39MP0010094_abnormal_chromosome_stability1.24468002
40MP0005647_abnormal_sex_gland1.24416022
41MP0001119_abnormal_female_reproductive1.24084650
42MP0009384_cardiac_valve_regurgitation1.21229660
43MP0002272_abnormal_nervous_system1.21165590
44MP0001501_abnormal_sleep_pattern1.16313141
45MP0000470_abnormal_stomach_morphology1.10413780
46MP0000631_abnormal_neuroendocrine_gland1.05317616
47MP0003936_abnormal_reproductive_system1.05280906
48MP0001145_abnormal_male_reproductive1.03917236
49MP0005551_abnormal_eye_electrophysiolog0.98859746
50MP0001730_embryonic_growth_arrest0.98758470
51MP0005220_abnormal_exocrine_pancreas0.98399906
52MP0005645_abnormal_hypothalamus_physiol0.97919877
53MP0004742_abnormal_vestibular_system0.97247871
54MP0000230_abnormal_systemic_arterial0.95212320
55MP0003077_abnormal_cell_cycle0.94516939
56MP0008961_abnormal_basal_metabolism0.93121669
57MP0009745_abnormal_behavioral_response0.92937160
58MP0004142_abnormal_muscle_tone0.92898793
59MP0001440_abnormal_grooming_behavior0.92350205
60MP0001881_abnormal_mammary_gland0.92154971
61MP0001764_abnormal_homeostasis0.91553427
62MP0004145_abnormal_muscle_electrophysio0.90387340
63MP0002163_abnormal_gland_morphology0.90355361
64MP0002184_abnormal_innervation0.88558601
65MP0000350_abnormal_cell_proliferation0.84970144
66MP0003646_muscle_fatigue0.84449226
67MP0002234_abnormal_pharynx_morphology0.84440076
68MP0004130_abnormal_muscle_cell0.82775997
69MP0009046_muscle_twitch0.82468283
70MP0002249_abnormal_larynx_morphology0.81602251
71MP0003959_abnormal_lean_body0.80457548
72MP0002837_dystrophic_cardiac_calcinosis0.79823550
73MP0008057_abnormal_DNA_replication0.78582492
74MP0003937_abnormal_limbs/digits/tail_de0.78241095
75MP0004133_heterotaxia0.77975015
76MP0003183_abnormal_peptide_metabolism0.77887634
77MP0002876_abnormal_thyroid_physiology0.77114100
78MP0002396_abnormal_hematopoietic_system0.76710024
79MP0002067_abnormal_sensory_capabilities0.76686792
80MP0004233_abnormal_muscle_weight0.74932762
81MP0002229_neurodegeneration0.72485110
82MP0001286_abnormal_eye_development0.71322186
83MP0003806_abnormal_nucleotide_metabolis0.71017040
84MP0005394_taste/olfaction_phenotype0.68995668
85MP0005499_abnormal_olfactory_system0.68995668
86MP0003938_abnormal_ear_development0.68611358
87MP0008932_abnormal_embryonic_tissue0.66865284
88MP0001944_abnormal_pancreas_morphology0.66109193
89MP0000534_abnormal_ureter_morphology0.65811111
90MP0002102_abnormal_ear_morphology0.64838446
91MP0003635_abnormal_synaptic_transmissio0.64570991
92MP0002085_abnormal_embryonic_tissue0.64427698
93MP0003787_abnormal_imprinting0.64283694
94MP0003935_abnormal_craniofacial_develop0.63293240
95MP0009703_decreased_birth_body0.61851104
96MP0002693_abnormal_pancreas_physiology0.61269964
97MP0005253_abnormal_eye_physiology0.60673155
98MP0005395_other_phenotype0.59969323
99MP0000372_irregular_coat_pigmentation0.59264194
100MP0009250_abnormal_appendicular_skeleto0.59144201

Predicted human phenotypes

RankGene SetZ-score
1Premature ovarian failure (HP:0008209)6.35968556
2Metaphyseal dysplasia (HP:0100255)4.78840591
3Aplasia/Hypoplasia of the tibia (HP:0005772)4.33695728
4Chromsome breakage (HP:0040012)4.23441275
5Short tibia (HP:0005736)4.12077080
6Abnormality of abdominal situs (HP:0011620)4.08252494
7Abdominal situs inversus (HP:0003363)4.08252494
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.72633048
9Median cleft lip (HP:0000161)3.43941267
10Impulsivity (HP:0100710)3.33381965
11Microglossia (HP:0000171)3.21803355
12Congenital sensorineural hearing impairment (HP:0008527)3.20724181
13Partial agenesis of the corpus callosum (HP:0001338)3.02209318
14Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.01887177
15Oligodactyly (hands) (HP:0001180)2.97354433
16Tetany (HP:0001281)2.95422795
17Hyperphosphatemia (HP:0002905)2.89426982
18Anterior segment dysgenesis (HP:0007700)2.87096661
19Abnormality of calcium-phosphate metabolism (HP:0100530)2.84672337
20Atonic seizures (HP:0010819)2.82666231
21Glossoptosis (HP:0000162)2.71288389
22Tetraparesis (HP:0002273)2.67041289
23Amelogenesis imperfecta (HP:0000705)2.65472185
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62183770
25Neonatal respiratory distress (HP:0002643)2.60334635
26Abnormality of the nasal septum (HP:0000419)2.59877651
27Pancreatic fibrosis (HP:0100732)2.53834381
28Short chin (HP:0000331)2.48200074
29Limb hypertonia (HP:0002509)2.47766198
30Brushfield spots (HP:0001088)2.41295416
31Abnormality of dental color (HP:0011073)2.40928392
32Genital tract atresia (HP:0001827)2.39778219
33Maternal diabetes (HP:0009800)2.35951187
34Hypophosphatemic rickets (HP:0004912)2.30939422
35Hyperalaninemia (HP:0003348)2.30322866
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30322866
37Abnormality of alanine metabolism (HP:0010916)2.30322866
38Short middle phalanx of the 5th finger (HP:0004220)2.29956108
39Medial flaring of the eyebrow (HP:0010747)2.29637565
40Facial cleft (HP:0002006)2.26250977
41Progressive inability to walk (HP:0002505)2.25708029
42Abnormal auditory evoked potentials (HP:0006958)2.25468676
43Male infertility (HP:0003251)2.25300565
44Abnormality of chromosome stability (HP:0003220)2.24753280
45Oligodactyly (HP:0012165)2.20544903
46Birth length less than 3rd percentile (HP:0003561)2.20457971
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.19173438
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.17999026
49Bony spicule pigmentary retinopathy (HP:0007737)2.17741498
50Abnormal number of incisors (HP:0011064)2.17693333
51Abnormal ciliary motility (HP:0012262)2.15785422
52Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.14372582
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.12784500
54Absent/shortened dynein arms (HP:0200106)2.12784500
55Autoimmune thrombocytopenia (HP:0001973)2.10183101
56Congenital primary aphakia (HP:0007707)2.07086348
57Abnormality of the fovea (HP:0000493)2.06720321
58Gait imbalance (HP:0002141)2.06677529
59Osteomalacia (HP:0002749)2.05716456
60Meckel diverticulum (HP:0002245)2.04292928
61Abnormality of the pubic bones (HP:0003172)2.03777002
62Optic nerve hypoplasia (HP:0000609)2.03314921
63Gaze-evoked nystagmus (HP:0000640)2.03173851
64Congenital stationary night blindness (HP:0007642)2.03088021
65Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.03045799
66Reticulocytopenia (HP:0001896)2.02757206
67Attenuation of retinal blood vessels (HP:0007843)2.00082372
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99912544
69Abnormality of the ileum (HP:0001549)1.98142460
70Abnormality of lateral ventricle (HP:0030047)1.97381703
71Abnormality of the costochondral junction (HP:0000919)1.96785739
72Aplasia/Hypoplasia of the fovea (HP:0008060)1.96000797
73Hypoplasia of the fovea (HP:0007750)1.96000797
74Tongue fasciculations (HP:0001308)1.95327077
75Adrenal hypoplasia (HP:0000835)1.95216508
76Progressive cerebellar ataxia (HP:0002073)1.93640879
77Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93302110
78Degeneration of the lateral corticospinal tracts (HP:0002314)1.93302110
79Dysdiadochokinesis (HP:0002075)1.91943837
80Enlarged epiphyses (HP:0010580)1.91521287
81Abnormality of sulfur amino acid metabolism (HP:0004339)1.89940965
82Abnormality of the phalanges of the 5th finger (HP:0004213)1.88729218
83Short thumb (HP:0009778)1.85928060
84Increased hepatocellular lipid droplets (HP:0006565)1.84464565
85Myokymia (HP:0002411)1.83902212
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82602087
87Absent thumb (HP:0009777)1.82569116
88Aplastic anemia (HP:0001915)1.79824349
89Nephroblastoma (Wilms tumor) (HP:0002667)1.77983929
90Febrile seizures (HP:0002373)1.77591338
91Type I diabetes mellitus (HP:0100651)1.76951234
92Azoospermia (HP:0000027)1.75519444
93Poor coordination (HP:0002370)1.75300438
94Hypokinesia (HP:0002375)1.75245072
95Clubbing of toes (HP:0100760)1.74971699
96Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.74072439
97Ectopic kidney (HP:0000086)1.73308320
98Abnormality of cells of the erythroid lineage (HP:0012130)1.72238780
99Microretrognathia (HP:0000308)1.71694104
100Loss of speech (HP:0002371)1.71041603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.81799510
2TNIK3.82368262
3TAOK33.52270045
4CDC73.49795465
5CDK123.35267023
6ZAK3.07253888
7CDK193.00353154
8STK242.49221524
9AURKA2.39410839
10PLK42.24983604
11GRK12.19197496
12TLK12.11386480
13SRPK12.05477295
14ICK1.91687999
15STK391.85950621
16ACVR1B1.77287868
17VRK11.76288952
18LATS21.65905144
19BMPR1B1.64304064
20TTK1.51715420
21BRAF1.50444106
22MAP3K91.41096568
23ADRBK21.37071193
24SGK21.36169859
25TEC1.35982201
26CHEK21.35720631
27ARAF1.30713132
28TGFBR11.30336713
29NLK1.22601982
30STK31.19615030
31PKN11.17780206
32TRIM281.17748045
33PRKD31.14172321
34CDK71.13495728
35TSSK61.10487371
36TESK21.06966066
37FRK1.03650780
38AURKB1.02524021
39MAP2K31.02317252
40WNK40.99690959
41MELK0.96417419
42PLK10.96065029
43OXSR10.94317922
44MAPK130.89415473
45NEK20.89189755
46MAP4K20.88799982
47AKT30.87857277
48NME10.86749140
49SGK2230.84006477
50SGK4940.84006477
51CHEK10.82949453
52WNK10.81742608
53STK38L0.80377229
54BUB10.76090130
55MAPKAPK30.74810599
56MAP3K30.73668155
57NUAK10.73396051
58PRKCI0.69207092
59VRK20.67452093
60NEK60.66489961
61PIM10.66182098
62MARK20.62905795
63LATS10.61322744
64SGK30.59189419
65AKT20.57641338
66CSNK1E0.56447708
67PASK0.55716556
68CSNK1D0.53924239
69EPHA40.51555732
70PRKD20.50343896
71NTRK20.49723016
72MAPKAPK20.48994440
73PBK0.47493636
74ABL20.47309104
75GRK50.45378253
76TNK20.45197212
77CDK20.43640004
78PLK30.39975569
79RPS6KA50.38709988
80CHUK0.37949433
81BRSK20.37227179
82MAP3K130.36235967
83PRKACA0.35731699
84NTRK30.35654144
85ADRBK10.34466916
86PIK3CA0.33683258
87ATM0.33297462
88CDK50.32173448
89CDK10.31397857
90GSK3B0.30180526
91PRKCQ0.29822033
92CAMK10.29590548
93MOS0.29295220
94GRK70.28872651
95CDK30.28108753
96MTOR0.27984608
97PRKG10.27626959
98PAK10.26875958
99PIK3CG0.26467329
100CSNK2A20.26384544

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005336.33105222
2Basal transcription factors_Homo sapiens_hsa030223.52956983
3Fatty acid biosynthesis_Homo sapiens_hsa000613.52318816
4Sulfur metabolism_Homo sapiens_hsa009203.20914131
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.66291922
6Ribosome_Homo sapiens_hsa030102.55646782
7Dorso-ventral axis formation_Homo sapiens_hsa043202.55200607
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.29173999
9Homologous recombination_Homo sapiens_hsa034402.16530070
10Phototransduction_Homo sapiens_hsa047442.15246159
11Ovarian steroidogenesis_Homo sapiens_hsa049132.03075866
12Bile secretion_Homo sapiens_hsa049761.98191328
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93075915
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81905989
15mRNA surveillance pathway_Homo sapiens_hsa030151.76613060
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.65784920
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.54406236
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.52467587
19Selenocompound metabolism_Homo sapiens_hsa004501.46861279
20Tryptophan metabolism_Homo sapiens_hsa003801.44847260
21Linoleic acid metabolism_Homo sapiens_hsa005911.40387374
22RNA transport_Homo sapiens_hsa030131.36239668
23Morphine addiction_Homo sapiens_hsa050321.35730297
24Olfactory transduction_Homo sapiens_hsa047401.35397316
25Mismatch repair_Homo sapiens_hsa034301.33772982
26Serotonergic synapse_Homo sapiens_hsa047261.33442539
27Taste transduction_Homo sapiens_hsa047421.31067124
28Oocyte meiosis_Homo sapiens_hsa041141.28941844
29Non-homologous end-joining_Homo sapiens_hsa034501.24299978
30Fanconi anemia pathway_Homo sapiens_hsa034601.20157648
31RNA polymerase_Homo sapiens_hsa030201.18495590
32Steroid biosynthesis_Homo sapiens_hsa001001.13811630
33Insulin secretion_Homo sapiens_hsa049111.10960340
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07035282
35GABAergic synapse_Homo sapiens_hsa047271.06855007
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04369547
37Retinol metabolism_Homo sapiens_hsa008301.03763934
38Nicotine addiction_Homo sapiens_hsa050331.01230077
39Circadian entrainment_Homo sapiens_hsa047131.00505400
40Cholinergic synapse_Homo sapiens_hsa047250.95119919
41Nitrogen metabolism_Homo sapiens_hsa009100.91794910
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90212869
43Butanoate metabolism_Homo sapiens_hsa006500.88932466
44Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88892303
45p53 signaling pathway_Homo sapiens_hsa041150.87048537
46Cell cycle_Homo sapiens_hsa041100.84597504
47Calcium signaling pathway_Homo sapiens_hsa040200.78790157
48Alcoholism_Homo sapiens_hsa050340.74340093
49Tight junction_Homo sapiens_hsa045300.71532985
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.70747468
51Folate biosynthesis_Homo sapiens_hsa007900.70033075
52Cocaine addiction_Homo sapiens_hsa050300.68574903
53RNA degradation_Homo sapiens_hsa030180.67028176
54Arachidonic acid metabolism_Homo sapiens_hsa005900.66718789
55Vitamin digestion and absorption_Homo sapiens_hsa049770.66465694
56Purine metabolism_Homo sapiens_hsa002300.66081037
57Chemical carcinogenesis_Homo sapiens_hsa052040.65940448
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.63902887
59Glutamatergic synapse_Homo sapiens_hsa047240.63204316
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62969801
61Dopaminergic synapse_Homo sapiens_hsa047280.62714833
62Spliceosome_Homo sapiens_hsa030400.60296399
63Salivary secretion_Homo sapiens_hsa049700.57953463
64Base excision repair_Homo sapiens_hsa034100.57246362
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55693988
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53651877
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53261771
68Gap junction_Homo sapiens_hsa045400.52976596
69Systemic lupus erythematosus_Homo sapiens_hsa053220.52686911
70Vitamin B6 metabolism_Homo sapiens_hsa007500.52261592
71Nucleotide excision repair_Homo sapiens_hsa034200.52086179
72Hippo signaling pathway_Homo sapiens_hsa043900.51213137
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50781808
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50471136
75Sphingolipid metabolism_Homo sapiens_hsa006000.48963014
76Amphetamine addiction_Homo sapiens_hsa050310.48795754
77Chemokine signaling pathway_Homo sapiens_hsa040620.47501653
78Pyrimidine metabolism_Homo sapiens_hsa002400.46770467
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45560806
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44978517
81Fat digestion and absorption_Homo sapiens_hsa049750.42069757
82Thyroid hormone synthesis_Homo sapiens_hsa049180.41144069
83Oxytocin signaling pathway_Homo sapiens_hsa049210.39877636
84Hedgehog signaling pathway_Homo sapiens_hsa043400.39789733
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39235571
86Huntingtons disease_Homo sapiens_hsa050160.37386465
87ABC transporters_Homo sapiens_hsa020100.36924267
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36499100
89Gastric acid secretion_Homo sapiens_hsa049710.36156084
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33695352
91Ether lipid metabolism_Homo sapiens_hsa005650.32820388
92cAMP signaling pathway_Homo sapiens_hsa040240.30970995
93MAPK signaling pathway_Homo sapiens_hsa040100.30890061
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29793380
95TGF-beta signaling pathway_Homo sapiens_hsa043500.29031351
96Pancreatic secretion_Homo sapiens_hsa049720.27903077
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.27291431
98Inositol phosphate metabolism_Homo sapiens_hsa005620.25895917
99Wnt signaling pathway_Homo sapiens_hsa043100.24627408
100Long-term depression_Homo sapiens_hsa047300.24199197

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »