TRIM49C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oocyte development (GO:0048599)7.99150625
2histone lysine demethylation (GO:0070076)7.32338064
3positive regulation of meiosis (GO:0045836)7.30092799
4synaptonemal complex organization (GO:0070193)7.10088802
5histone demethylation (GO:0016577)6.89008724
6positive regulation of meiotic cell cycle (GO:0051446)6.88990310
7synaptonemal complex assembly (GO:0007130)6.79711778
8regulation of RIG-I signaling pathway (GO:0039535)6.32964336
9gonadal mesoderm development (GO:0007506)6.21230709
10regulation of exit from mitosis (GO:0007096)6.17086312
11protein dealkylation (GO:0008214)6.16965156
12protein demethylation (GO:0006482)6.16965156
13negative regulation of Ras GTPase activity (GO:0034261)6.06160604
14multicellular organism reproduction (GO:0032504)5.89249407
15positive regulation of catecholamine secretion (GO:0033605)5.59568852
16regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)5.56682304
17N-terminal protein amino acid acetylation (GO:0006474)5.15618607
18regulation of acrosome reaction (GO:0060046)5.08862400
19protein K48-linked deubiquitination (GO:0071108)4.97764105
20piRNA metabolic process (GO:0034587)4.88660823
21regulation of alternative mRNA splicing, via spliceosome (GO:0000381)4.87242920
22male meiosis I (GO:0007141)4.65772397
23acrosome reaction (GO:0007340)4.59955139
24male meiosis (GO:0007140)4.56071591
25single fertilization (GO:0007338)4.35603983
26regulation of female receptivity (GO:0045924)4.35181924
27exocrine pancreas development (GO:0031017)4.31234712
28positive regulation of uterine smooth muscle contraction (GO:0070474)4.27294649
29chromosome organization involved in meiosis (GO:0070192)4.23822696
30centriole replication (GO:0007099)4.12370215
31protein K6-linked ubiquitination (GO:0085020)3.94030471
32auditory receptor cell differentiation (GO:0042491)3.93402281
33mechanoreceptor differentiation (GO:0042490)3.92491213
34reproduction (GO:0000003)3.88805823
35regulation of meiosis (GO:0040020)3.84538020
36protein K63-linked deubiquitination (GO:0070536)3.84246442
37negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.77291933
38pattern specification involved in kidney development (GO:0061004)3.75322076
39regulation of cytokine production involved in inflammatory response (GO:1900015)3.74809668
40response to UV-C (GO:0010225)3.71358008
41female mating behavior (GO:0060180)3.67476982
42radial glial cell differentiation (GO:0060019)3.58005177
43fertilization (GO:0009566)3.54958332
44binding of sperm to zona pellucida (GO:0007339)3.54555590
45positive regulation of histone H3-K4 methylation (GO:0051571)3.54118437
46cilium movement (GO:0003341)3.52635555
47meiosis I (GO:0007127)3.52445040
48regulation of histone H3-K9 methylation (GO:0051570)3.49566630
49regulation of ruffle assembly (GO:1900027)3.47488147
50inner ear receptor cell differentiation (GO:0060113)3.46755023
51retina layer formation (GO:0010842)3.42349036
52tyrosine metabolic process (GO:0006570)3.40802788
53epithelial cilium movement (GO:0003351)3.39964350
54telencephalon development (GO:0021537)3.30822030
55striated muscle atrophy (GO:0014891)3.30596673
56DNA methylation involved in gamete generation (GO:0043046)3.30412223
57regulation of DNA endoreduplication (GO:0032875)3.26728257
58citrulline biosynthetic process (GO:0019240)3.24666667
59poly(A)+ mRNA export from nucleus (GO:0016973)3.24203055
60neuron fate determination (GO:0048664)3.22863264
61axon ensheathment in central nervous system (GO:0032291)3.22796127
62central nervous system myelination (GO:0022010)3.22796127
63protein kinase C signaling (GO:0070528)3.21960062
64meiotic cell cycle (GO:0051321)3.20853476
65meiotic cell cycle process (GO:1903046)3.20488470
66regulation of uterine smooth muscle contraction (GO:0070472)3.20145130
67regulation of receptor binding (GO:1900120)3.18918658
68demethylation (GO:0070988)3.17913170
69regulation of retinoic acid receptor signaling pathway (GO:0048385)3.17573248
70negative regulation of oligodendrocyte differentiation (GO:0048715)3.15689467
71regulation of defense response to virus by host (GO:0050691)3.10929085
72aggressive behavior (GO:0002118)3.10734436
73microtubule severing (GO:0051013)3.10725352
74intestinal epithelial cell development (GO:0060576)3.09007922
75negative regulation of smooth muscle cell differentiation (GO:0051151)3.07654651
76regulation of meiotic cell cycle (GO:0051445)3.07283379
77regulation of double-strand break repair via homologous recombination (GO:0010569)3.04465609
78pancreas development (GO:0031016)3.03245851
79hair cell differentiation (GO:0035315)3.01878477
80negative regulation of astrocyte differentiation (GO:0048712)3.01836498
81cellular response to glucose starvation (GO:0042149)3.01022246
82glycerophospholipid catabolic process (GO:0046475)3.00365926
83vitamin catabolic process (GO:0009111)2.97595175
84fat-soluble vitamin catabolic process (GO:0042363)2.97595175
85L-phenylalanine catabolic process (GO:0006559)2.97152408
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97152408
87regulation of mRNA splicing, via spliceosome (GO:0048024)2.97113289
88reciprocal DNA recombination (GO:0035825)2.95939533
89reciprocal meiotic recombination (GO:0007131)2.95939533
90regulation of penile erection (GO:0060405)2.94313274
91muscle atrophy (GO:0014889)2.93454189
92regulation of helicase activity (GO:0051095)2.92358450
93cellular anion homeostasis (GO:0030002)2.91060049
94phosphate ion homeostasis (GO:0055062)2.89942245
95trivalent inorganic anion homeostasis (GO:0072506)2.89942245
96negative regulation of stem cell proliferation (GO:2000647)2.89619785
97centriole assembly (GO:0098534)2.88209951
98positive regulation of digestive system process (GO:0060456)2.88181812
99retinal rod cell development (GO:0046548)2.83775807
100histone H3-K9 demethylation (GO:0033169)18.9011553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.36713160
2EZH2_22144423_ChIP-Seq_EOC_Human6.69413119
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.47525677
4VDR_22108803_ChIP-Seq_LS180_Human3.73398134
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.18505345
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.16241053
7GBX2_23144817_ChIP-Seq_PC3_Human3.15569344
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.93007505
9IGF1R_20145208_ChIP-Seq_DFB_Human2.72395548
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34767707
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.29429443
12TOP2B_26459242_ChIP-Seq_MCF-7_Human2.28972405
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.26391674
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02901824
15IRF1_19129219_ChIP-ChIP_H3396_Human2.02884430
16RXR_22108803_ChIP-Seq_LS180_Human1.99896018
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99593373
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92153547
19SMAD4_21799915_ChIP-Seq_A2780_Human1.87840688
20TCF4_23295773_ChIP-Seq_U87_Human1.87398853
21AR_21572438_ChIP-Seq_LNCaP_Human1.80158035
22PRDM14_20953172_ChIP-Seq_ESCs_Human1.74892302
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.74776149
24AUTS2_25519132_ChIP-Seq_293T-REX_Human1.74668074
25STAT3_23295773_ChIP-Seq_U87_Human1.74004406
26TP53_20018659_ChIP-ChIP_R1E_Mouse1.72427943
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.72152925
28RNF2_27304074_Chip-Seq_NSC_Mouse1.66354058
29SMAD3_21741376_ChIP-Seq_HESCs_Human1.63942712
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63301728
31CBP_21632823_ChIP-Seq_H3396_Human1.62079766
32P300_19829295_ChIP-Seq_ESCs_Human1.60840824
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59660404
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57340676
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57016785
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56663195
37AR_25329375_ChIP-Seq_VCAP_Human1.56487483
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56215998
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56147109
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.55942096
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55703306
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54222791
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52679169
44SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.49251297
45TAF15_26573619_Chip-Seq_HEK293_Human1.48865107
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48342490
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46914811
48SMAD4_21741376_ChIP-Seq_HESCs_Human1.46840418
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45487243
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.45023461
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.42283049
52TCF4_22108803_ChIP-Seq_LS180_Human1.39876441
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36453234
54NCOR_22424771_ChIP-Seq_293T_Human1.35231253
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34666204
56TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.34175356
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.31535288
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.31504820
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31333060
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31333060
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30618246
62BCAT_22108803_ChIP-Seq_LS180_Human1.30312261
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29147909
64AR_21909140_ChIP-Seq_LNCAP_Human1.28583298
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28413160
66RUNX2_22187159_ChIP-Seq_PCA_Human1.25769242
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.25023930
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23522154
69GF1_26923725_Chip-Seq_HPCs_Mouse1.22482767
70MYC_18940864_ChIP-ChIP_HL60_Human1.20116023
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19900653
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18796842
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18338769
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16906876
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16371442
76STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.14668902
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13416738
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13192215
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11386650
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09188329
81TP63_23658742_ChIP-Seq_EP156T_Human1.08085938
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07941572
83GATA3_26560356_Chip-Seq_TH1_Human1.07893441
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07148667
85SMRT_27268052_Chip-Seq_Bcells_Human1.05453683
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04652397
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01940397
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.00050318
89RNF2_27304074_Chip-Seq_ESCs_Mouse0.96368553
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96286803
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.94790276
92CJUN_26792858_Chip-Seq_BT549_Human0.93534961
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92959403
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91871528
95REST_21632747_ChIP-Seq_MESCs_Mouse0.90948152
96MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90540164
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90140660
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90120978
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89316045
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89108105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.73653339
2MP0003283_abnormal_digestive_organ4.56578875
3MP0002837_dystrophic_cardiac_calcinosis3.91714879
4MP0003950_abnormal_plasma_membrane3.91627008
5MP0003136_yellow_coat_color3.81850946
6MP0009379_abnormal_foot_pigmentation3.68763250
7MP0000678_abnormal_parathyroid_gland3.64670553
8MP0002160_abnormal_reproductive_system3.16825472
9MP0003693_abnormal_embryo_hatching3.09118236
10MP0000427_abnormal_hair_cycle2.75745382
11MP0006276_abnormal_autonomic_nervous2.69297652
12MP0005220_abnormal_exocrine_pancreas2.52839945
13MP0005410_abnormal_fertilization2.40320772
14MP0001664_abnormal_digestion2.17948476
15MP0008877_abnormal_DNA_methylation2.16721760
16MP0001929_abnormal_gametogenesis2.16720308
17MP0001502_abnormal_circadian_rhythm2.13244228
18MP0002210_abnormal_sex_determination2.00158535
19MP0003119_abnormal_digestive_system2.00134421
20MP0009840_abnormal_foam_cell1.87775706
21MP0000049_abnormal_middle_ear1.77752808
22MP0008058_abnormal_DNA_repair1.75779474
23MP0005360_urolithiasis1.75030889
24MP0003699_abnormal_female_reproductive1.71854004
25MP0002751_abnormal_autonomic_nervous1.61187128
26MP0004858_abnormal_nervous_system1.52682028
27MP0003890_abnormal_embryonic-extraembry1.49678818
28MP0003866_abnormal_defecation1.47251425
29MP0001666_abnormal_nutrient_absorption1.47201748
30MP0006072_abnormal_retinal_apoptosis1.43748574
31MP0000653_abnormal_sex_gland1.41709744
32MP0005389_reproductive_system_phenotype1.41596407
33MP0003183_abnormal_peptide_metabolism1.39874544
34MP0003868_abnormal_feces_composition1.39375851
35MP0000372_irregular_coat_pigmentation1.36991760
36MP0000778_abnormal_nervous_system1.34823715
37MP0002090_abnormal_vision1.31957498
38MP0000470_abnormal_stomach_morphology1.31058766
39MP0003698_abnormal_male_reproductive1.30959782
40MP0005647_abnormal_sex_gland1.29411609
41MP0005646_abnormal_pituitary_gland1.26045651
42MP0010094_abnormal_chromosome_stability1.21752862
43MP0002184_abnormal_innervation1.18510782
44MP0004381_abnormal_hair_follicle1.14715287
45MP0000462_abnormal_digestive_system1.14393561
46MP0000230_abnormal_systemic_arterial1.12971457
47MP0002102_abnormal_ear_morphology1.12894447
48MP0009697_abnormal_copulation1.11269150
49MP0002161_abnormal_fertility/fecundity1.11216280
50MP0004742_abnormal_vestibular_system1.09950233
51MP0001119_abnormal_female_reproductive1.09629447
52MP0004859_abnormal_synaptic_plasticity1.09628486
53MP0001145_abnormal_male_reproductive1.08608792
54MP0003938_abnormal_ear_development1.08018400
55MP0001501_abnormal_sleep_pattern1.07691989
56MP0004233_abnormal_muscle_weight1.04039620
57MP0001730_embryonic_growth_arrest1.03174350
58MP0002163_abnormal_gland_morphology1.02632342
59MP0001286_abnormal_eye_development1.01229877
60MP0009765_abnormal_xenobiotic_induced1.01111172
61MP0003718_maternal_effect1.01013945
62MP0001986_abnormal_taste_sensitivity1.00215111
63MP0000631_abnormal_neuroendocrine_gland0.99673414
64MP0005623_abnormal_meninges_morphology0.96830685
65MP0004043_abnormal_pH_regulation0.94864047
66MP0000490_abnormal_crypts_of0.94301891
67MP0009384_cardiac_valve_regurgitation0.92186066
68MP0002095_abnormal_skin_pigmentation0.90682498
69MP0003936_abnormal_reproductive_system0.89704802
70MP0000534_abnormal_ureter_morphology0.87432331
71MP0003121_genomic_imprinting0.86744584
72MP0003077_abnormal_cell_cycle0.85966891
73MP0005379_endocrine/exocrine_gland_phen0.84411551
74MP0005076_abnormal_cell_differentiation0.83009390
75MP0003186_abnormal_redox_activity0.82948724
76MP0000026_abnormal_inner_ear0.81738878
77MP0002229_neurodegeneration0.81315144
78MP0005551_abnormal_eye_electrophysiolog0.79516880
79MP0000015_abnormal_ear_pigmentation0.79007328
80MP0002277_abnormal_respiratory_mucosa0.78564504
81MP0003879_abnormal_hair_cell0.77312238
82MP0005195_abnormal_posterior_eye0.76581578
83MP0001440_abnormal_grooming_behavior0.75316467
84MP0009745_abnormal_behavioral_response0.75134666
85MP0002693_abnormal_pancreas_physiology0.74243219
86MP0003959_abnormal_lean_body0.72467604
87MP0002249_abnormal_larynx_morphology0.71522875
88MP0002272_abnormal_nervous_system0.69343558
89MP0000350_abnormal_cell_proliferation0.68630098
90MP0004270_analgesia0.67464297
91MP0000428_abnormal_craniofacial_morphol0.64692794
92MP0005171_absent_coat_pigmentation0.64572530
93MP0000955_abnormal_spinal_cord0.62586160
94MP0002396_abnormal_hematopoietic_system0.60608177
95MP0001963_abnormal_hearing_physiology0.59703683
96MP0002127_abnormal_cardiovascular_syste0.58339592
97MP0002067_abnormal_sensory_capabilities0.58082335
98MP0002752_abnormal_somatic_nervous0.55685802
99MP0005645_abnormal_hypothalamus_physiol0.55235042
100MP0000647_abnormal_sebaceous_gland0.55064961

Predicted human phenotypes

RankGene SetZ-score
1Premature ovarian failure (HP:0008209)6.73794281
2Median cleft lip (HP:0000161)5.18267901
3Aplasia/Hypoplasia of the tibia (HP:0005772)4.50348500
4Short chin (HP:0000331)4.45394967
5Short tibia (HP:0005736)4.43802608
6Abnormal number of incisors (HP:0011064)4.37297539
7Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.32208064
8Maternal diabetes (HP:0009800)4.30892313
9Microglossia (HP:0000171)4.19634037
10Atonic seizures (HP:0010819)4.19082015
11Pancreatic fibrosis (HP:0100732)3.81994621
12Abnormality of the nasal septum (HP:0000419)3.80893512
13Oligodactyly (hands) (HP:0001180)3.72609882
14Facial cleft (HP:0002006)3.65355165
15Abnormal auditory evoked potentials (HP:0006958)3.60924964
16Hyperphosphatemia (HP:0002905)3.46348222
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.45792924
18Type I diabetes mellitus (HP:0100651)3.40158832
19Congenital sensorineural hearing impairment (HP:0008527)3.37887354
20Tetany (HP:0001281)3.31241984
21Submucous cleft hard palate (HP:0000176)3.30346497
22Abnormal ciliary motility (HP:0012262)3.25414445
23Decreased subcutaneous fat (HP:0001002)3.14546642
24Degeneration of the lateral corticospinal tracts (HP:0002314)3.08262896
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.08262896
26Absent phalangeal crease (HP:0006109)3.02861130
27Metaphyseal dysplasia (HP:0100255)3.01892508
28Impulsivity (HP:0100710)2.95215334
29Optic nerve hypoplasia (HP:0000609)2.94196515
30Tetraparesis (HP:0002273)2.93598828
31Amelogenesis imperfecta (HP:0000705)2.93559824
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.93321750
33Abnormality of dental color (HP:0011073)2.92495774
34Adrenal hypoplasia (HP:0000835)2.85149026
35Abnormal respiratory motile cilium physiology (HP:0012261)2.83782528
36Coronal craniosynostosis (HP:0004440)2.71644162
37Abnormality of calcium-phosphate metabolism (HP:0100530)2.71484880
38Abdominal situs inversus (HP:0003363)2.68539562
39Abnormality of abdominal situs (HP:0011620)2.68539562
40Abnormality of the corticospinal tract (HP:0002492)2.67046403
41Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.63921756
42Abnormality of the incisor (HP:0000676)2.61455534
43Ectopic kidney (HP:0000086)2.60016960
44Abnormality of the labia minora (HP:0012880)2.48762627
45Neurofibrillary tangles (HP:0002185)2.45814465
46Oligodactyly (HP:0012165)2.43172663
47Abnormal finger flexion creases (HP:0006143)2.39944131
48Autoimmune thrombocytopenia (HP:0001973)2.39790282
49Rhinitis (HP:0012384)2.39546317
50Anhidrosis (HP:0000970)2.33394005
51Chromsome breakage (HP:0040012)2.26763447
52Abnormality of subcutaneous fat tissue (HP:0001001)2.23393956
53Hypophosphatemic rickets (HP:0004912)2.21973554
54Conical tooth (HP:0000698)2.18533557
55Absent/shortened dynein arms (HP:0200106)2.16717832
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.16717832
57Hepatoblastoma (HP:0002884)2.16304966
58Myokymia (HP:0002411)2.11946363
59Hypoplasia of the iris (HP:0007676)2.10028645
60Reticulocytopenia (HP:0001896)2.08893915
61Abnormality of permanent molar morphology (HP:0011071)2.08564356
62Abnormality of the dental root (HP:0006486)2.08564356
63Taurodontia (HP:0000679)2.08564356
64Osteomalacia (HP:0002749)2.04998430
65Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.04044485
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03875405
67Abnormal pancreas size (HP:0012094)2.03873972
68Preaxial hand polydactyly (HP:0001177)1.99992112
69Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.98255884
70Abnormal respiratory motile cilium morphology (HP:0005938)1.97178624
71Abnormal respiratory epithelium morphology (HP:0012253)1.97178624
72Partial agenesis of the corpus callosum (HP:0001338)1.96448394
73Facial hemangioma (HP:0000329)1.96200803
74Microretrognathia (HP:0000308)1.95486405
75Genital tract atresia (HP:0001827)1.93352067
76Abnormality of chromosome stability (HP:0003220)1.92845132
77Aplasia/Hypoplasia of the earlobes (HP:0009906)1.92791273
78Glossoptosis (HP:0000162)1.92073420
79Bifid uvula (HP:0000193)1.91868980
80Abnormality of molar morphology (HP:0011070)1.90028332
81Abnormality of molar (HP:0011077)1.90028332
82Abnormality of lateral ventricle (HP:0030047)1.88914132
83Prostate neoplasm (HP:0100787)1.88591245
84Loss of speech (HP:0002371)1.88260343
85Abnormality of the dental pulp (HP:0006479)1.87174589
86Urinary bladder sphincter dysfunction (HP:0002839)1.84258838
87Postaxial foot polydactyly (HP:0001830)1.83761546
88Abnormal eating behavior (HP:0100738)1.82399747
89Male infertility (HP:0003251)1.82319233
90Spinal muscular atrophy (HP:0007269)1.82000685
91Apathy (HP:0000741)1.79748657
92Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78873326
93Abnormality of the frontal sinuses (HP:0002687)1.76214364
94Exertional dyspnea (HP:0002875)1.75598919
95Diminished motivation (HP:0000745)1.75191580
96Abnormality of purine metabolism (HP:0004352)1.74728960
97True hermaphroditism (HP:0010459)1.70427108
98Fair hair (HP:0002286)1.69854942
99Convex nasal ridge (HP:0000444)1.65638264
100Prenatal maternal abnormality (HP:0002686)1.65045049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.35048243
2CDK124.16059742
3TNIK3.68219307
4TAOK33.43235273
5PLK43.21253403
6STK393.10723698
7CDK192.99217021
8AURKA2.66592047
9VRK12.33797585
10ACVR1B2.27113262
11ICK2.20512795
12NTRK22.02491385
13LATS21.83961592
14ZAK1.83905229
15BMPR1B1.83701371
16NLK1.79179180
17TLK11.78143085
18TEC1.67946139
19CDC71.61960070
20LATS11.61451288
21ARAF1.58021321
22WNK11.47365925
23STK31.41946098
24MARK21.41317962
25WNK41.34108562
26TTK1.31305055
27MAP2K31.29676093
28NUAK11.26152544
29PBK1.25546660
30TYRO31.25327191
31EPHA41.23719402
32PKN11.15982777
33PLK21.14990858
34MELK1.14725382
35CHEK21.14274340
36PIM21.07915560
37MAP3K31.05991147
38SGK21.05051652
39OXSR11.02418533
40SRPK10.97764089
41AURKB0.96570585
42BRAF0.93535131
43STK240.93209259
44PIK3CA0.88094522
45EPHA30.86210751
46MST40.84722856
47PLK10.81964934
48BCR0.77952185
49GRK70.76559907
50STK110.70302061
51MOS0.69471907
52TRIM280.67896237
53MAPK110.66985550
54TESK20.66840977
55CAMK40.64177971
56SGK2230.63267610
57SGK4940.63267610
58MAPK130.62568403
59PIM10.61229028
60FRK0.60467954
61TGFBR10.59169425
62RAF10.58567060
63STK38L0.56044869
64PRKG20.55955639
65CDK70.52649448
66CHEK10.51686574
67DMPK0.50493801
68CDK80.49558120
69MAPKAPK20.49158331
70GRK10.48402813
71MTOR0.46336271
72PINK10.45800111
73SGK30.45787263
74PRKACA0.44315223
75PIK3CG0.42890054
76MUSK0.40331807
77CDK50.38445035
78PRKD10.38075617
79CDK20.36419048
80VRK20.36373886
81GRK50.34501485
82PAK10.34438568
83PRKCQ0.33806919
84CSNK1E0.33002176
85CAMK10.32703139
86CDK10.32224497
87EPHB10.31589234
88PRKCZ0.30733102
89ILK0.30492582
90STK40.30029329
91PLK30.29921523
92RPS6KA50.29751494
93RPS6KA30.29653192
94AKT20.29548534
95ATM0.28948752
96CSNK1D0.28853864
97RPS6KA10.27608671
98PRKG10.27405685
99PRKACB0.26792371
100CAMK2A0.24788795

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005337.63456756
2Dorso-ventral axis formation_Homo sapiens_hsa043204.53052788
3Homologous recombination_Homo sapiens_hsa034403.10756454
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.07787293
5Bile secretion_Homo sapiens_hsa049762.90905954
6Mismatch repair_Homo sapiens_hsa034302.45266201
7Basal transcription factors_Homo sapiens_hsa030222.17104491
8Ribosome_Homo sapiens_hsa030102.15787058
9Fatty acid biosynthesis_Homo sapiens_hsa000611.99451208
10Tryptophan metabolism_Homo sapiens_hsa003801.74435401
11Fanconi anemia pathway_Homo sapiens_hsa034601.72802743
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71408423
13Sulfur metabolism_Homo sapiens_hsa009201.70405301
14RNA degradation_Homo sapiens_hsa030181.68107951
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.65286067
16Insulin secretion_Homo sapiens_hsa049111.57000972
17Linoleic acid metabolism_Homo sapiens_hsa005911.53210520
18Phototransduction_Homo sapiens_hsa047441.51679877
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.51283108
20Vitamin B6 metabolism_Homo sapiens_hsa007501.45938114
21Retinol metabolism_Homo sapiens_hsa008301.45054659
22Non-homologous end-joining_Homo sapiens_hsa034501.43158176
23Olfactory transduction_Homo sapiens_hsa047401.40398938
24Tyrosine metabolism_Homo sapiens_hsa003501.22820709
25Alcoholism_Homo sapiens_hsa050341.22141483
26Systemic lupus erythematosus_Homo sapiens_hsa053221.11592257
27Hedgehog signaling pathway_Homo sapiens_hsa043401.11360068
28Chemical carcinogenesis_Homo sapiens_hsa052041.10911519
29Ovarian steroidogenesis_Homo sapiens_hsa049131.04939270
30Oocyte meiosis_Homo sapiens_hsa041141.03753344
31Serotonergic synapse_Homo sapiens_hsa047261.03130808
32RNA transport_Homo sapiens_hsa030131.00862506
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98301912
34mRNA surveillance pathway_Homo sapiens_hsa030150.96511859
35Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93037357
36Cholinergic synapse_Homo sapiens_hsa047250.92564310
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91785903
38Gap junction_Homo sapiens_hsa045400.91684663
39cAMP signaling pathway_Homo sapiens_hsa040240.89732157
40Colorectal cancer_Homo sapiens_hsa052100.89275594
41Lysine degradation_Homo sapiens_hsa003100.88249308
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87849134
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.84750200
44Starch and sucrose metabolism_Homo sapiens_hsa005000.83798822
45Tight junction_Homo sapiens_hsa045300.80707390
46Adherens junction_Homo sapiens_hsa045200.80087294
47GABAergic synapse_Homo sapiens_hsa047270.79270230
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78179881
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.77958467
50Cocaine addiction_Homo sapiens_hsa050300.74960958
51Hippo signaling pathway_Homo sapiens_hsa043900.74508337
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74288007
53Circadian entrainment_Homo sapiens_hsa047130.73816497
54Salivary secretion_Homo sapiens_hsa049700.73207927
55Basal cell carcinoma_Homo sapiens_hsa052170.72401288
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71501925
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68345539
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61163740
59Morphine addiction_Homo sapiens_hsa050320.61002769
60Thyroid hormone synthesis_Homo sapiens_hsa049180.60371421
61RNA polymerase_Homo sapiens_hsa030200.58724702
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57763452
63Arachidonic acid metabolism_Homo sapiens_hsa005900.57650556
64Nicotine addiction_Homo sapiens_hsa050330.55735075
65Pancreatic secretion_Homo sapiens_hsa049720.54093577
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53507642
67Steroid biosynthesis_Homo sapiens_hsa001000.53335981
68DNA replication_Homo sapiens_hsa030300.50694533
69Wnt signaling pathway_Homo sapiens_hsa043100.45695317
70Calcium signaling pathway_Homo sapiens_hsa040200.44658389
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43562316
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42765027
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39474674
74Circadian rhythm_Homo sapiens_hsa047100.39033386
75Protein digestion and absorption_Homo sapiens_hsa049740.36839782
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35977053
77PPAR signaling pathway_Homo sapiens_hsa033200.34513766
78Dopaminergic synapse_Homo sapiens_hsa047280.34178915
79Spliceosome_Homo sapiens_hsa030400.32806576
80Axon guidance_Homo sapiens_hsa043600.32053549
81MAPK signaling pathway_Homo sapiens_hsa040100.30606630
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29543106
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29264306
84Purine metabolism_Homo sapiens_hsa002300.29056159
85Gastric acid secretion_Homo sapiens_hsa049710.28371595
86Estrogen signaling pathway_Homo sapiens_hsa049150.28027447
87Cell cycle_Homo sapiens_hsa041100.27679008
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27110405
89p53 signaling pathway_Homo sapiens_hsa041150.27047792
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26772772
91Rap1 signaling pathway_Homo sapiens_hsa040150.25689426
92Herpes simplex infection_Homo sapiens_hsa051680.25552197
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.25507415
94Oxytocin signaling pathway_Homo sapiens_hsa049210.24232102
95TGF-beta signaling pathway_Homo sapiens_hsa043500.23613940
96Renin-angiotensin system_Homo sapiens_hsa046140.23146602
97Butanoate metabolism_Homo sapiens_hsa006500.22295839
98Glutamatergic synapse_Homo sapiens_hsa047240.20048999
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19040753
100Huntingtons disease_Homo sapiens_hsa050160.17826140

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