TRIM50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma lipoprotein particle assembly (GO:0034377)6.81510911
2regulation of cholesterol esterification (GO:0010872)6.56099260
3very-low-density lipoprotein particle assembly (GO:0034379)6.45448182
4protein-lipid complex assembly (GO:0065005)6.24706304
5cholesterol efflux (GO:0033344)6.11628590
6negative regulation of cholesterol transport (GO:0032375)6.09716061
7negative regulation of sterol transport (GO:0032372)6.09716061
8negative regulation of fibrinolysis (GO:0051918)5.81266456
9protein-lipid complex remodeling (GO:0034368)5.76820311
10macromolecular complex remodeling (GO:0034367)5.76820311
11plasma lipoprotein particle remodeling (GO:0034369)5.76820311
12peptidyl-glutamic acid carboxylation (GO:0017187)5.52029751
13protein carboxylation (GO:0018214)5.52029751
14low-density lipoprotein particle remodeling (GO:0034374)5.49313039
15regulation of cholesterol homeostasis (GO:2000188)5.45548781
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.44447774
17high-density lipoprotein particle remodeling (GO:0034375)5.36072385
18plasma lipoprotein particle clearance (GO:0034381)5.34163322
19cardiac right ventricle morphogenesis (GO:0003215)5.29486580
20plasma lipoprotein particle organization (GO:0071827)5.24092387
21superoxide anion generation (GO:0042554)5.20143216
22cellular response to lithium ion (GO:0071285)5.17261171
23piRNA metabolic process (GO:0034587)5.04781899
24synapsis (GO:0007129)5.04689653
25regulation of bile acid biosynthetic process (GO:0070857)5.04543102
26protein-lipid complex subunit organization (GO:0071825)5.02648572
27reverse cholesterol transport (GO:0043691)5.00343191
28regulation of fibrinolysis (GO:0051917)4.95585175
29intestinal absorption (GO:0050892)4.68706955
30negative regulation of homotypic cell-cell adhesion (GO:0034111)4.65640766
31phospholipid efflux (GO:0033700)4.58019376
32regulation of plasminogen activation (GO:0010755)4.53019990
33positive regulation of fatty acid biosynthetic process (GO:0045723)4.51959699
34positive regulation of heat generation (GO:0031652)4.47849820
35notochord development (GO:0030903)4.42167685
36regulation of fever generation (GO:0031620)4.35587384
37positive regulation by symbiont of host defense response (GO:0052509)4.29872487
38modulation by symbiont of host defense response (GO:0052031)4.29872487
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.29872487
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.29872487
41positive regulation by organism of defense response of other organism involved in symbiotic interact4.29872487
42modulation by symbiont of host immune response (GO:0052553)4.29872487
43regulation of protein activation cascade (GO:2000257)4.27253781
44regulation of complement activation (GO:0030449)4.24886367
45regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.24026838
46response to peptidoglycan (GO:0032494)4.17880176
47DNA methylation involved in gamete generation (GO:0043046)4.10969273
48lung epithelium development (GO:0060428)4.09186691
49sterol transport (GO:0015918)4.01874207
50cholesterol transport (GO:0030301)4.01874207
51proline metabolic process (GO:0006560)4.01645051
52synaptonemal complex assembly (GO:0007130)3.97790949
53cholesterol homeostasis (GO:0042632)3.97683927
54embryonic camera-type eye development (GO:0031076)3.96652948
55diacylglycerol metabolic process (GO:0046339)3.96347142
56homocysteine metabolic process (GO:0050667)3.95547555
57chromosome organization involved in meiosis (GO:0070192)3.94131041
58sterol homeostasis (GO:0055092)3.91215932
59regulation of apoptotic cell clearance (GO:2000425)3.88953615
60regulation of phospholipase A2 activity (GO:0032429)3.86603175
61male meiosis I (GO:0007141)3.86601664
62positive regulation of chemokine biosynthetic process (GO:0045080)3.83404516
63positive regulation of lipoprotein lipase activity (GO:0051006)3.83154819
64positive regulation of triglyceride lipase activity (GO:0061365)3.83154819
65SMAD protein signal transduction (GO:0060395)3.80766761
66regulation of platelet aggregation (GO:0090330)3.75233281
67response to muramyl dipeptide (GO:0032495)3.72456360
68blood coagulation, intrinsic pathway (GO:0007597)3.71929811
69negative regulation of digestive system process (GO:0060457)3.70748803
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.67773645
71acylglycerol homeostasis (GO:0055090)3.61591537
72triglyceride homeostasis (GO:0070328)3.61591537
73L-phenylalanine catabolic process (GO:0006559)3.61422076
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.61422076
75L-phenylalanine metabolic process (GO:0006558)3.61326969
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.61326969
77negative regulation of osteoblast proliferation (GO:0033689)3.57486180
78positive regulation of steroid metabolic process (GO:0045940)3.55349519
79bone trabecula formation (GO:0060346)3.53867220
80opioid receptor signaling pathway (GO:0038003)3.53645775
81I-kappaB phosphorylation (GO:0007252)3.50588118
82regulation of non-canonical Wnt signaling pathway (GO:2000050)3.48770678
83regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.47149117
84phosphate ion homeostasis (GO:0055062)3.44774563
85trivalent inorganic anion homeostasis (GO:0072506)3.44774563
86artery smooth muscle contraction (GO:0014824)3.42034935
87lipoprotein metabolic process (GO:0042157)3.41589124
88sex differentiation (GO:0007548)3.41116534
89negative regulation of lipase activity (GO:0060192)3.39002473
90negative regulation of lipid transport (GO:0032369)3.38673404
91glutamate metabolic process (GO:0006536)3.37875312
92macrophage activation involved in immune response (GO:0002281)3.37656014
93synaptonemal complex organization (GO:0070193)3.36477852
94positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.35527289
95endocardial cushion development (GO:0003197)3.34867166
96endocrine hormone secretion (GO:0060986)3.34029977
97mitochondrial DNA replication (GO:0006264)3.33997311
98low-density lipoprotein particle clearance (GO:0034383)3.31292216
99positive regulation of hormone metabolic process (GO:0032352)3.30576606
100glycosphingolipid catabolic process (GO:0046479)3.26444990
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25390184
102response to host immune response (GO:0052572)3.25390184
103ventricular trabecula myocardium morphogenesis (GO:0003222)3.25189384
104response to lithium ion (GO:0010226)3.23762044
105lipid homeostasis (GO:0055088)3.22748293
106male meiosis (GO:0007140)3.21717680
107regulation of triglyceride catabolic process (GO:0010896)3.20530621
108positive regulation of extracellular matrix organization (GO:1903055)3.19757500
109acute-phase response (GO:0006953)3.19710747
110lipopolysaccharide-mediated signaling pathway (GO:0031663)3.19370521
111positive regulation of hormone biosynthetic process (GO:0046886)3.19086391
112histone H3-K9 demethylation (GO:0033169)3.18234416
113positive regulation of tumor necrosis factor production (GO:0032760)3.18109696
114embryonic foregut morphogenesis (GO:0048617)3.16382506
115negative regulation of metanephros development (GO:0072217)3.16057537
116mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.15167605
117positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.15167605
118complement activation, alternative pathway (GO:0006957)3.14385368
119gonadal mesoderm development (GO:0007506)3.14196181
120digestion (GO:0007586)3.12040122
121positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.09488578
122cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.09049538
123regulation of cholesterol biosynthetic process (GO:0045540)3.07695144
124detection of molecule of bacterial origin (GO:0032490)3.05803293
125response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.04693092
126response to host (GO:0075136)3.04693092
127response to host defenses (GO:0052200)3.04693092
128detection of other organism (GO:0098543)3.04602329
129regulation of lipoprotein particle clearance (GO:0010984)3.04158572
130positive regulation of cellular amide metabolic process (GO:0034250)3.02692492
131positive regulation of cellular amine metabolic process (GO:0033240)3.01576277
132tonic smooth muscle contraction (GO:0014820)3.01273410
133regulation of fatty acid biosynthetic process (GO:0042304)2.99703621
134glycolipid catabolic process (GO:0019377)2.98884685
135pinocytosis (GO:0006907)2.98573174
136regulation of extracellular matrix organization (GO:1903053)2.97880856
137regulation of male gonad development (GO:2000018)2.97052385
138regulation of heat generation (GO:0031650)2.96613945
139sulfate transmembrane transport (GO:1902358)2.95139229
140hydrogen peroxide biosynthetic process (GO:0050665)2.93304943
141regulation of chemokine biosynthetic process (GO:0045073)2.93010952
142microglial cell activation (GO:0001774)2.92220351
143positive regulation of monocyte chemotaxis (GO:0090026)2.91707720
144drinking behavior (GO:0042756)2.91368918
145oligosaccharide catabolic process (GO:0009313)2.90855789
146positive regulation of bone mineralization (GO:0030501)2.90556808
147negative regulation of cAMP-mediated signaling (GO:0043951)2.89353455
148pH reduction (GO:0045851)2.87817781
149response to follicle-stimulating hormone (GO:0032354)2.87306280
150positive regulation of hair cycle (GO:0042635)2.86917121
151positive regulation of hair follicle development (GO:0051798)2.86917121
152response to folic acid (GO:0051593)2.86614841
153regulation of synapse maturation (GO:0090128)2.81451718
154leukotriene metabolic process (GO:0006691)2.79527632
155hematopoietic stem cell proliferation (GO:0071425)2.76638190
156chondrocyte proliferation (GO:0035988)2.76539222
157eosinophil chemotaxis (GO:0048245)2.74174292
158intestinal cholesterol absorption (GO:0030299)2.73915827
159maintenance of gastrointestinal epithelium (GO:0030277)2.73420365
160positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.73268846
161limb bud formation (GO:0060174)2.72451050
162ceramide catabolic process (GO:0046514)2.70368932
163negative regulation of myoblast differentiation (GO:0045662)2.69084817
164smooth muscle cell differentiation (GO:0051145)2.67509407
165positive regulation of biomineral tissue development (GO:0070169)2.67420510
166cobalamin metabolic process (GO:0009235)2.63728934
167regulation of homotypic cell-cell adhesion (GO:0034110)2.60863301
168neutrophil activation involved in immune response (GO:0002283)2.58062031
169positive regulation of interleukin-1 beta secretion (GO:0050718)2.56175880
170positive regulation of interferon-alpha production (GO:0032727)2.53306172
171positive regulation of nitric oxide biosynthetic process (GO:0045429)2.52513141
172regulation of hair follicle development (GO:0051797)2.52129990
173positive regulation of mitochondrial membrane permeability (GO:0035794)2.51927062
174regulation of interferon-alpha production (GO:0032647)2.51535798
175reflex (GO:0060004)2.51085722
176exocrine pancreas development (GO:0031017)2.50119250
177G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.50041818
178regulation of metalloenzyme activity (GO:0048552)2.49683722
179cardiac ventricle morphogenesis (GO:0003208)2.48916757
180detection of bacterium (GO:0016045)2.48605191
181negative regulation of systemic arterial blood pressure (GO:0003085)2.48418629
182heart valve formation (GO:0003188)2.48035897
183histamine secretion (GO:0001821)2.47504313
184positive regulation of male gonad development (GO:2000020)2.47190195
185detection of external biotic stimulus (GO:0098581)2.46716181
186negative regulation of interleukin-12 production (GO:0032695)2.44666635
187antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.44022311
188negative regulation of bone mineralization (GO:0030502)2.41707187
189detection of biotic stimulus (GO:0009595)2.40790382
190regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.39625469
191reactive oxygen species biosynthetic process (GO:1903409)2.39500312
192regulation of female gonad development (GO:2000194)2.35954407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.57864488
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.03458444
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.72032070
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.96610870
5GBX2_23144817_ChIP-Seq_PC3_Human3.81415559
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.70023020
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.60187368
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.46037624
9FOXA2_19822575_ChIP-Seq_HepG2_Human3.43726924
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.20966307
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.10896606
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.05774689
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.89126330
14IGF1R_20145208_ChIP-Seq_DFB_Human2.75106536
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.69522083
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.66579858
17ZNF263_19887448_ChIP-Seq_K562_Human2.66195256
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.58448062
19HNF4A_19822575_ChIP-Seq_HepG2_Human2.58076901
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.49145831
21AR_21572438_ChIP-Seq_LNCaP_Human2.46566573
22EZH2_22144423_ChIP-Seq_EOC_Human2.44136419
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.43065120
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.40874953
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.39032184
26ESR1_15608294_ChIP-ChIP_MCF-7_Human2.35331245
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21521710
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.20418496
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.19585637
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.16456751
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13886850
32BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13467901
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12906038
34* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.05853284
35LXR_22292898_ChIP-Seq_THP-1_Human2.04066900
36SUZ12_27294783_Chip-Seq_NPCs_Mouse2.02065914
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.93140177
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.91544286
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90102221
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87502274
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.81688123
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.80793487
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.80417732
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77632055
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.77127163
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.76947257
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73325540
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73325540
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.70266829
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.69961628
51* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69283398
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66994896
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64325079
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63362717
55GATA4_25053715_ChIP-Seq_YYC3_Human1.63286746
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61333049
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55804620
58STAT3_18555785_Chip-Seq_ESCs_Mouse1.54373241
59P300_19829295_ChIP-Seq_ESCs_Human1.54157452
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52792015
61TAF15_26573619_Chip-Seq_HEK293_Human1.51265971
62RNF2_27304074_Chip-Seq_NSC_Mouse1.49948802
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49266781
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.49221140
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.48399767
66P53_22387025_ChIP-Seq_ESCs_Mouse1.47673741
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47120829
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46310942
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46217817
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45975360
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.44170400
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42953217
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42427950
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41844895
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41097122
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.40942646
77* P68_20966046_ChIP-Seq_HELA_Human1.40600823
78SMAD4_21799915_ChIP-Seq_A2780_Human1.40491540
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.40191464
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37318568
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36663918
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.35667168
83SOX2_18555785_Chip-Seq_ESCs_Mouse1.35263287
84CLOCK_20551151_ChIP-Seq_293T_Human1.34696008
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.34002319
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33659111
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33101755
88* BCOR_27268052_Chip-Seq_Bcells_Human1.32977411
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32799970
90SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32062686
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31677892
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31677892
93NMYC_18555785_Chip-Seq_ESCs_Mouse1.31006986
94SOX11_22085726_ChIP-Seq_ESNs_Mouse1.30596628
95* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30203409
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29727896
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29433765
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29250140
99JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28703951
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28364148
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.27751093
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27420610
103RUNX1_27457419_Chip-Seq_LIVER_Mouse1.27255670
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26663007
105RARA_24833708_ChIP-Seq_LIVER_Mouse1.25817776
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25049828
107RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24660864
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24353695
109* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23733554
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.23395055
111SMC4_20622854_ChIP-Seq_HELA_Human1.23383964
112DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22710906
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22693344
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22317253
115PU1_27457419_Chip-Seq_LIVER_Mouse1.22076037
116RNF2_27304074_Chip-Seq_ESCs_Mouse1.22056487
117VDR_24787735_ChIP-Seq_THP-1_Human1.20744112
118P300_18555785_Chip-Seq_ESCs_Mouse1.20378104
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.20233293
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19288466
121SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19167138
122TP53_18474530_ChIP-ChIP_U2OS_Human1.18805754
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.17509806
124BCL6_27268052_Chip-Seq_Bcells_Human1.17113600
125ZFX_18555785_Chip-Seq_ESCs_Mouse1.17081359
126ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17020611
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16755371
128* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16227056
129AHR_22903824_ChIP-Seq_MCF-7_Human1.15681506
130RARB_24833708_ChIP-Seq_LIVER_Mouse1.15616459
131EZH2_27294783_Chip-Seq_ESCs_Mouse1.15106699
132CTCF_18555785_Chip-Seq_ESCs_Mouse1.14280845
133RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14045368
134RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13683794
135SOX2_21211035_ChIP-Seq_LN229_Human1.13633427
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13171126
137SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12738406
138SMAD3_21741376_ChIP-Seq_EPCs_Human1.12630424
139TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12221271
140OCT4_18555785_Chip-Seq_ESCs_Mouse1.11652608
141ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09559656
142CDX2_20551321_ChIP-Seq_CACO-2_Human1.08356878
143* PHF8_20622854_ChIP-Seq_HELA_Human1.06635658
144ESR2_21235772_ChIP-Seq_MCF-7_Human1.06272564
145EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05759024
146STAT3_23295773_ChIP-Seq_U87_Human1.05517207
147MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05250031
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04945753
149IRF8_27001747_Chip-Seq_BMDM_Mouse1.04048354
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03786856
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03786856
152TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03674034
153CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03158518
154CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02936204
155KLF4_18555785_Chip-Seq_ESCs_Mouse1.02184114
156SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02146624
157TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02140890
158STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01972688
159RUNX2_22187159_ChIP-Seq_PCA_Human1.01901579
160MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01760560
161KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01739952
162KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01739952
163KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01739952
164RAC3_21632823_ChIP-Seq_H3396_Human1.00716862
165GATA6_25053715_ChIP-Seq_YYC3_Human1.00237763
166TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99881412
167NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.97236481
168KLF4_19829295_ChIP-Seq_ESCs_Human0.96482950
169OCT4_20526341_ChIP-Seq_ESCs_Human0.95579496
170TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95445925
171CTCF_27219007_Chip-Seq_Bcells_Human0.94707223
172ESET_19884257_ChIP-Seq_ESCs_Mouse0.92442711
173GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91915270
174YY1_21170310_ChIP-Seq_MESCs_Mouse0.91559888
175* TET1_21451524_ChIP-Seq_MESCs_Mouse0.90430993
176* E2F1_20622854_ChIP-Seq_HELA_Human0.87834407
177RACK7_27058665_Chip-Seq_MCF-7_Human0.87506817
178MYC_27129775_Chip-Seq_CORNEA_Mouse0.87155111
179ELF1_20517297_ChIP-Seq_JURKAT_Human0.86941428
180TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86635126
181GATA3_21867929_ChIP-Seq_CD8_Mouse0.82279007
182OCT4_19829295_ChIP-Seq_ESCs_Human0.80503435
183ETS1_21867929_ChIP-Seq_TH2_Mouse0.80126328
184ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79824181
185SOX2_22085726_ChIP-Seq_NPCs_Mouse0.77889241
186CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77291264
187GATA1_19941827_ChIP-Seq_MEL_Mouse0.77242108
188TCF4_18268006_ChIP-ChIP_LS174T_Human0.74530468
189CEBPB_22108803_ChIP-Seq_LS180_Human0.73846517
190NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73723359
191FOXH1_21741376_ChIP-Seq_ESCs_Human0.73104431
192P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.72699048
193DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72216270
194SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.71100318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.95041412
2MP0008004_abnormal_stomach_pH5.72784390
3MP0002139_abnormal_hepatobiliary_system5.68361335
4MP0005365_abnormal_bile_salt4.57187975
5MP0002102_abnormal_ear_morphology4.35974930
6MP0000566_synostosis4.11838253
7MP0001188_hyperpigmentation3.98840248
8MP0003136_yellow_coat_color3.00985213
9MP0005085_abnormal_gallbladder_physiolo2.74592021
10MP0010329_abnormal_lipoprotein_level2.69499829
11MP0003880_abnormal_central_pattern2.59219262
12MP0008877_abnormal_DNA_methylation2.55191756
13MP0005451_abnormal_body_composition2.53504785
14MP0002277_abnormal_respiratory_mucosa2.44637826
15MP0001666_abnormal_nutrient_absorption2.33720699
16MP0003183_abnormal_peptide_metabolism2.31205574
17MP0005058_abnormal_lysosome_morphology2.25761630
18MP0002160_abnormal_reproductive_system2.14801247
19MP0005171_absent_coat_pigmentation2.04943553
20MP0006082_CNS_inflammation2.04248830
21MP0002876_abnormal_thyroid_physiology2.03481723
22MP0008995_early_reproductive_senescence2.00100747
23MP0003646_muscle_fatigue1.99723731
24MP0002148_abnormal_hypersensitivity_rea1.96516402
25MP0003941_abnormal_skin_development1.90684181
26MP0000372_irregular_coat_pigmentation1.88705163
27MP0004381_abnormal_hair_follicle1.86650197
28MP0003172_abnormal_lysosome_physiology1.85807293
29MP0009840_abnormal_foam_cell1.84370481
30MP0002735_abnormal_chemical_nociception1.83796845
31MP0003787_abnormal_imprinting1.78805133
32MP0009780_abnormal_chondrocyte_physiolo1.76979628
33MP0008260_abnormal_autophagy1.75711692
34MP0001664_abnormal_digestion1.75611846
35MP0003567_abnormal_fetal_cardiomyocyte1.74646345
36MP0002419_abnormal_innate_immunity1.74422732
37MP0009785_altered_susceptibility_to1.74359351
38MP0006292_abnormal_olfactory_placode1.73068760
39MP0004782_abnormal_surfactant_physiolog1.71758538
40MP0004484_altered_response_of1.71559693
41MP0005257_abnormal_intraocular_pressure1.70640392
42MP0001661_extended_life_span1.69491138
43MP0009764_decreased_sensitivity_to1.67255914
44MP0002249_abnormal_larynx_morphology1.65745680
45MP0001835_abnormal_antigen_presentation1.62600497
46MP0000470_abnormal_stomach_morphology1.58583112
47MP0000579_abnormal_nail_morphology1.58545574
48MP0008875_abnormal_xenobiotic_pharmacok1.58433269
49MP0004510_myositis1.57703106
50MP0010368_abnormal_lymphatic_system1.52113488
51MP0001299_abnormal_eye_distance/1.51016894
52MP0000678_abnormal_parathyroid_gland1.49474863
53MP0005084_abnormal_gallbladder_morpholo1.45777428
54MP0002210_abnormal_sex_determination1.45700822
55MP0009697_abnormal_copulation1.43705753
56MP0000762_abnormal_tongue_morphology1.42085791
57MP0002089_abnormal_postnatal_growth/wei1.41976140
58MP0000049_abnormal_middle_ear1.36677292
59MP0003195_calcinosis1.36069655
60MP0001963_abnormal_hearing_physiology1.35846762
61MP0001501_abnormal_sleep_pattern1.35303572
62MP0002118_abnormal_lipid_homeostasis1.34121304
63MP0009046_muscle_twitch1.33759770
64MP0001486_abnormal_startle_reflex1.33654479
65MP0005645_abnormal_hypothalamus_physiol1.29818844
66MP0005389_reproductive_system_phenotype1.28519995
67MP0002736_abnormal_nociception_after1.27701533
68MP0001929_abnormal_gametogenesis1.27538838
69MP0004858_abnormal_nervous_system1.27481135
70MP0003868_abnormal_feces_composition1.27228070
71MP0002933_joint_inflammation1.21698081
72MP0000026_abnormal_inner_ear1.21650407
73MP0003436_decreased_susceptibility_to1.21599265
74MP0000343_altered_response_to1.21296917
75MP0005220_abnormal_exocrine_pancreas1.21176944
76MP0003879_abnormal_hair_cell1.20623727
77MP0000653_abnormal_sex_gland1.20237227
78MP0001145_abnormal_male_reproductive1.19476017
79MP0000639_abnormal_adrenal_gland1.19161177
80MP0005332_abnormal_amino_acid1.17389699
81MP0004134_abnormal_chest_morphology1.17210755
82MP0003724_increased_susceptibility_to1.13986378
83MP0003115_abnormal_respiratory_system1.13701437
84MP0002998_abnormal_bone_remodeling1.13144711
85MP0003119_abnormal_digestive_system1.12944407
86MP0003315_abnormal_perineum_morphology1.12572032
87MP0005646_abnormal_pituitary_gland1.12029531
88MP0004019_abnormal_vitamin_homeostasis1.09474171
89MP0000490_abnormal_crypts_of1.06647376
90MP0003890_abnormal_embryonic-extraembry1.05978598
91MP0009384_cardiac_valve_regurgitation1.05816421
92MP0009250_abnormal_appendicular_skeleto1.05590498
93MP0003718_maternal_effect1.05296373
94MP0000013_abnormal_adipose_tissue1.04121582
95MP0000609_abnormal_liver_physiology1.02955843
96MP0005025_abnormal_response_to1.02872555
97MP0003698_abnormal_male_reproductive1.02848396
98MP0003943_abnormal_hepatobiliary_system1.02837874
99MP0006276_abnormal_autonomic_nervous1.02271048
100MP0005076_abnormal_cell_differentiation1.01696419
101MP0003123_paternal_imprinting1.01321048
102MP0001533_abnormal_skeleton_physiology1.00024622
103MP0003699_abnormal_female_reproductive0.98785606
104MP0005410_abnormal_fertilization0.98766125
105MP0000163_abnormal_cartilage_morphology0.98668282
106MP0005083_abnormal_biliary_tract0.98577817
107MP0003121_genomic_imprinting0.97756588
108MP0002115_abnormal_skeleton_extremities0.97320326
109MP0001968_abnormal_touch/_nociception0.97141301
110MP0005000_abnormal_immune_tolerance0.94989126
111MP0001764_abnormal_homeostasis0.93432476
112MP0003828_pulmonary_edema0.92193767
113MP0002332_abnormal_exercise_endurance0.88990488
114MP0002452_abnormal_antigen_presenting0.88500938
115MP0002282_abnormal_trachea_morphology0.88251111
116MP0003122_maternal_imprinting0.87999925
117MP0005165_increased_susceptibility_to0.86947263
118MP0003252_abnormal_bile_duct0.86768956
119MP0003045_fibrosis0.86743712
120MP0001119_abnormal_female_reproductive0.86535077
121MP0005390_skeleton_phenotype0.84013205
122MP0002971_abnormal_brown_adipose0.82671616
123MP0002127_abnormal_cardiovascular_syste0.81742871
124MP0001186_pigmentation_phenotype0.81546157
125MP0003448_altered_tumor_morphology0.81115964
126MP0005387_immune_system_phenotype0.79900068
127MP0001790_abnormal_immune_system0.79900068
128MP0005167_abnormal_blood-brain_barrier0.79877862
129MP0001915_intracranial_hemorrhage0.79756369
130MP0003942_abnormal_urinary_system0.78156333
131MP0003283_abnormal_digestive_organ0.77346107
132MP0003953_abnormal_hormone_level0.76925793
133MP0005319_abnormal_enzyme/_coenzyme0.76773595
134MP0000598_abnormal_liver_morphology0.76027277
135MP0005409_darkened_coat_color0.75947612
136MP0003795_abnormal_bone_structure0.75355385
137MP0002161_abnormal_fertility/fecundity0.75296081
138MP0003755_abnormal_palate_morphology0.74590369
139MP0005330_cardiomyopathy0.73748759
140MP0009333_abnormal_splenocyte_physiolog0.72865831
141MP0000003_abnormal_adipose_tissue0.72360622
142MP0005395_other_phenotype0.71224445
143MP0002067_abnormal_sensory_capabilities0.71065545
144MP0002113_abnormal_skeleton_development0.70265102
145MP0006138_congestive_heart_failure0.70056116
146MP0002108_abnormal_muscle_morphology0.69858526
147MP0009642_abnormal_blood_homeostasis0.69509788
148MP0004264_abnormal_extraembryonic_tissu0.69261973
149MP0002723_abnormal_immune_serum0.69125226
150MP0009745_abnormal_behavioral_response0.68900927
151MP0005666_abnormal_adipose_tissue0.68700488
152MP0002168_other_aberrant_phenotype0.67304240
153MP0002132_abnormal_respiratory_system0.66420272
154MP0005464_abnormal_platelet_physiology0.66086867
155MP0010630_abnormal_cardiac_muscle0.62952332
156MP0000371_diluted_coat_color0.62781230
157MP0002106_abnormal_muscle_physiology0.62376213
158MP0005448_abnormal_energy_balance0.62339731
159MP0004185_abnormal_adipocyte_glucose0.61824515
160MP0002638_abnormal_pupillary_reflex0.61204659
161MP0001845_abnormal_inflammatory_respons0.60506269
162MP0005647_abnormal_sex_gland0.60255325
163MP0005375_adipose_tissue_phenotype0.60171069
164MP0005369_muscle_phenotype0.59220520
165MP0002896_abnormal_bone_mineralization0.59218745
166MP0002233_abnormal_nose_morphology0.57533943
167MP0002938_white_spotting0.52140020
168MP0002078_abnormal_glucose_homeostasis0.50215143
169MP0002909_abnormal_adrenal_gland0.49718693
170MP0005367_renal/urinary_system_phenotyp0.49551964
171MP0000516_abnormal_urinary_system0.49551964
172MP0003936_abnormal_reproductive_system0.48866930
173MP0009643_abnormal_urine_homeostasis0.47936200
174MP0001270_distended_abdomen0.45813689
175MP0005636_abnormal_mineral_homeostasis0.44369351

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.30615325
2Joint hemorrhage (HP:0005261)6.09332299
3Prolonged partial thromboplastin time (HP:0003645)5.29327624
4Mixed hearing impairment (HP:0000410)4.71898394
5Hypercholesterolemia (HP:0003124)4.58932903
6Hemorrhage of the eye (HP:0011885)4.51541217
7Neonatal short-limb short stature (HP:0008921)4.48876787
8Complement deficiency (HP:0004431)4.44839120
9Epiphyseal dysplasia (HP:0002656)4.28632666
10Hypobetalipoproteinemia (HP:0003563)4.14526701
11Abnormality of aromatic amino acid family metabolism (HP:0004338)4.05009310
12Oligodactyly (hands) (HP:0001180)4.04438375
13Irregular epiphyses (HP:0010582)3.94490553
14Split foot (HP:0001839)3.94361464
15Glomerulonephritis (HP:0000099)3.92887046
16Menstrual irregularities (HP:0000858)3.91645703
17Unilateral renal agenesis (HP:0000122)3.91265395
18Xanthomatosis (HP:0000991)3.89848840
19Gonadal dysgenesis (HP:0000133)3.88903890
20Vitreoretinal degeneration (HP:0000655)3.88889233
21Systemic lupus erythematosus (HP:0002725)3.79135949
22Abnormality of incisor morphology (HP:0011063)3.66517533
23Megaloblastic anemia (HP:0001889)3.66455845
24Flat acetabular roof (HP:0003180)3.62733582
25Abnormality of homocysteine metabolism (HP:0010919)3.55204367
26Homocystinuria (HP:0002156)3.55204367
27Cheilitis (HP:0100825)3.42993708
28Hypoplastic ischia (HP:0003175)3.40080751
29Abnormality of the lumbar spine (HP:0100712)3.38266840
30Osteomalacia (HP:0002749)3.35179425
31Reduced antithrombin III activity (HP:0001976)3.31908373
32Conical tooth (HP:0000698)3.31414454
33Short femoral neck (HP:0100864)3.30842321
34Abnormality of carpal bone ossification (HP:0006257)3.29721466
35Oligodactyly (HP:0012165)3.28233083
36Focal motor seizures (HP:0011153)3.28099487
37Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.20657758
38Recurrent abscess formation (HP:0002722)3.20369082
39Arthropathy (HP:0003040)3.16398624
40Male infertility (HP:0003251)3.12509257
41Recurrent gram-negative bacterial infections (HP:0005420)3.06386383
42Abnormality of complement system (HP:0005339)3.05043570
43Abnormal number of erythroid precursors (HP:0012131)3.02981480
44Eczematoid dermatitis (HP:0000976)2.97838363
45Optic neuritis (HP:0100653)2.97132446
46Retrobulbar optic neuritis (HP:0100654)2.97132446
47Flat capital femoral epiphysis (HP:0003370)2.93671756
48Vascular calcification (HP:0004934)2.93417049
49Recurrent bacterial skin infections (HP:0005406)2.93064571
50Absent hand (HP:0004050)2.92755609
51Protruding tongue (HP:0010808)2.91192308
52Abnormality of the ischium (HP:0003174)2.90849074
53Mediastinal lymphadenopathy (HP:0100721)2.88810935
54Spontaneous abortion (HP:0005268)2.84381236
55Chronic mucocutaneous candidiasis (HP:0002728)2.82993640
56Recurrent cutaneous fungal infections (HP:0011370)2.82993640
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.81255381
58Gonadotropin excess (HP:0000837)2.80743930
59Hypophosphatemic rickets (HP:0004912)2.80254774
60Orchitis (HP:0100796)2.78300244
61Beaking of vertebral bodies (HP:0004568)2.71225209
62Broad palm (HP:0001169)2.68691303
63Hypolipoproteinemia (HP:0010981)2.67649099
64Abnormality of cells of the erythroid lineage (HP:0012130)2.66019376
65Cupped ribs (HP:0000887)2.63361426
66Natal tooth (HP:0000695)2.57782150
67Abnormality of the common coagulation pathway (HP:0010990)2.57137899
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.56315590
69Hypoplasia of the fovea (HP:0007750)2.56315590
70Partial duplication of thumb phalanx (HP:0009944)2.56152633
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53800076
72Pigmentary retinal degeneration (HP:0001146)2.53703721
73Small epiphyses (HP:0010585)2.51267470
74Abnormal hand bone ossification (HP:0010660)2.50963001
75Broad alveolar ridges (HP:0000187)2.48198500
76Recurrent corneal erosions (HP:0000495)2.45835618
77Cardiovascular calcification (HP:0011915)2.45563609
78Mitral stenosis (HP:0001718)2.45445630
79Type I transferrin isoform profile (HP:0003642)2.43415246
80Prostate neoplasm (HP:0100787)2.43210433
81Abnormal ossification of hand bones (HP:0005921)2.35171099
82Diaphragmatic weakness (HP:0009113)2.34625602
83Anomalous pulmonary venous return (HP:0010772)2.33528503
84Aplasia/hypoplasia of the femur (HP:0005613)2.31535264
85Testicular neoplasm (HP:0010788)2.31158005
86Abnormality of vitamin metabolism (HP:0100508)2.30906171
87Nonprogressive disorder (HP:0003680)2.30732699
88Recurrent skin infections (HP:0001581)2.28556494
89Barrel-shaped chest (HP:0001552)2.27154849
90Rickets (HP:0002748)2.26599404
91Myositis (HP:0100614)2.26388608
92Fat malabsorption (HP:0002630)2.24795596
93Aplasia involving bones of the extremities (HP:0009825)2.24643038
94Aplasia involving bones of the upper limbs (HP:0009823)2.24643038
95Aplasia of the phalanges of the hand (HP:0009802)2.24643038
96Chronic obstructive pulmonary disease (HP:0006510)2.23282846
97Obstructive lung disease (HP:0006536)2.23282846
98Hyperglycinemia (HP:0002154)2.19068865
99Febrile seizures (HP:0002373)2.18674766
100Congenital sensorineural hearing impairment (HP:0008527)2.18494226
101Vaginal fistula (HP:0004320)2.18488011
102Facial shape deformation (HP:0011334)2.18274390
103Potter facies (HP:0002009)2.18274390
104Menorrhagia (HP:0000132)2.17092376
105Absent epiphyses (HP:0010577)2.15319251
106Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.15319251
107Abnormal tarsal ossification (HP:0008369)2.14626056
108Hypoalphalipoproteinemia (HP:0003233)2.14455454
109Neonatal death (HP:0003811)2.12589598
110Xerostomia (HP:0000217)2.12533862
111Abnormal foot bone ossification (HP:0010675)2.12029337
112Bronchomalacia (HP:0002780)2.11876716
113Type 2 muscle fiber atrophy (HP:0003554)2.11740498
114Purpura (HP:0000979)2.11677795
115Gout (HP:0001997)2.10608642
116Partial duplication of the phalanx of hand (HP:0009999)2.09044622
117Abnormality of the thoracic spine (HP:0100711)2.08225630
118Abnormality of the vitreous humor (HP:0004327)2.05776544
119Protrusio acetabuli (HP:0003179)2.04683569
120Stomatitis (HP:0010280)2.04033402
121Abnormality of the wing of the ilium (HP:0011867)2.03615169
122Periauricular skin pits (HP:0100277)2.02996526
123Preauricular pit (HP:0004467)2.02996526
124Turricephaly (HP:0000262)2.02749106
125Enlarged kidneys (HP:0000105)1.99545251
126Abnormality of vitamin B metabolism (HP:0004340)1.99278686
127Acanthocytosis (HP:0001927)1.98108869
128Growth hormone excess (HP:0000845)1.96716850
129Mesangial abnormality (HP:0001966)1.96115926
130Limited elbow extension (HP:0001377)1.95465662
131Skin pits (HP:0100276)1.94449899
132Retinal atrophy (HP:0001105)1.94068380
133Abnormality of the acetabulum (HP:0003170)1.93099143
134Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92897722
135Abnormality of the fovea (HP:0000493)1.92408576
136Abnormality of the pubic bones (HP:0003172)1.92201888
137Abnormality of macrophages (HP:0004311)1.90310668
138Limited hip movement (HP:0008800)1.89792322
139Abnormal ventriculo-arterial connection (HP:0011563)1.89444081
140Transposition of the great arteries (HP:0001669)1.89444081
141Abnormal connection of the cardiac segments (HP:0011545)1.89444081
142Abnormality of the vitamin B12 metabolism (HP:0004341)1.89172632
143Azoospermia (HP:0000027)1.88445958
144Recurrent fungal infections (HP:0002841)1.88038923
145Osteoarthritis (HP:0002758)1.85908075
146Bifid scrotum (HP:0000048)1.85174080
147Abnormality of glycine metabolism (HP:0010895)1.84901589
148Abnormality of serine family amino acid metabolism (HP:0010894)1.84901589
149Abnormal sex determination (HP:0012244)1.84300981
150Sex reversal (HP:0012245)1.84300981
151Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.84237302
152Recurrent pneumonia (HP:0006532)1.83832931
153Abnormality of the pulmonary veins (HP:0011718)1.82498309
154Hypoplastic ilia (HP:0000946)1.82393252
155Coxa vara (HP:0002812)1.82284937
156Thoracic kyphosis (HP:0002942)1.81993427
157Premature ovarian failure (HP:0008209)1.81264805
158Asymmetry of the thorax (HP:0001555)1.79715852
159Delayed epiphyseal ossification (HP:0002663)1.79631716
160Hemoptysis (HP:0002105)1.79035105
161Alacrima (HP:0000522)1.78500292
162Dysostosis multiplex (HP:0000943)1.78079650
163Genu varum (HP:0002970)1.76760546
164Abnormality of the intervertebral disk (HP:0005108)1.76513868
165Flattened epiphyses (HP:0003071)1.75720179
166Fetal akinesia sequence (HP:0001989)1.75166362
167Opisthotonus (HP:0002179)1.73183057
168Hypothermia (HP:0002045)1.72644716
169Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.72592628
170Steatorrhea (HP:0002570)1.71899428
171Coronal craniosynostosis (HP:0004440)1.68957449
172Cerebral palsy (HP:0100021)1.68678023
173Submucous cleft hard palate (HP:0000176)1.68420456
174Medial flaring of the eyebrow (HP:0010747)1.67561993
175Nasolacrimal duct obstruction (HP:0000579)1.67369271
176Alveolar cell carcinoma (HP:0006519)1.66081721
177Aplasia of the musculature (HP:0100854)1.65691695
178Chromsome breakage (HP:0040012)1.65640416
179Metaphyseal irregularity (HP:0003025)1.65323595
180Abnormality of macular pigmentation (HP:0008002)1.62411058
181Vascular tortuosity (HP:0004948)1.62093802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR45.79823557
2PINK15.12146873
3PRPF4B5.00866249
4CASK4.36217861
5ICK4.00763867
6TAOK24.00740254
7MAPK73.68897025
8DAPK23.32135871
9PNCK3.00111240
10TYRO32.81724934
11RIPK12.70878226
12TXK2.53008427
13MUSK2.49520024
14TRIB32.40555544
15AKT32.36993869
16YES12.36751515
17RIPK42.25233076
18ACVR1B2.16404903
19MAP3K142.14886477
20NUAK12.13096443
21MET2.12155389
22CSF1R2.07681635
23RPS6KL11.99642776
24RPS6KC11.99642776
25RPS6KA61.87851302
26TIE11.80388467
27WNK41.78437082
28ADRBK21.76803054
29RET1.70220919
30ZAK1.63748441
31DYRK1B1.62847854
32DDR21.59115091
33DAPK11.57291950
34PIK3CG1.52851680
35MST1R1.49724603
36ERBB31.48748989
37BUB11.48243351
38PDGFRA1.46566636
39EIF2AK21.43083155
40CAMK1G1.39049357
41GRK71.37840664
42IRAK31.34527147
43SMG11.29115235
44MST41.26927118
45EIF2AK31.23878011
46NTRK31.23458693
47MAP3K121.22173084
48SIK11.21928971
49MAP2K31.21026461
50WNK11.20815172
51MAP3K91.18229137
52EEF2K1.16528110
53PDPK11.14441389
54CDK91.12820887
55PRKAA21.10081928
56CDK71.09647351
57NLK1.06886787
58EPHB21.04520125
59TGFBR21.04278091
60INSRR1.03335619
61ERBB41.00856651
62GRK50.99760106
63CDK190.99697477
64TBK10.97413155
65BMPR20.96051655
66MAP2K20.95752224
67MELK0.93852611
68MAP2K70.92044789
69FGFR10.91044422
70CDK120.90961182
71IRAK40.89756927
72GRK10.89227963
73MAP3K110.88879349
74PDGFRB0.88058779
75CSK0.87491428
76BMPR1B0.86166272
77PTK20.85187006
78SIK30.84650517
79CDK40.83843159
80CLK10.82528877
81PDK10.78117289
82PKN20.78065343
83IKBKB0.76035201
84MAPK110.75777821
85MAP3K50.75650769
86CDK30.72289062
87MAPK130.71785935
88CAMKK20.71498902
89MATK0.71471817
90BRD40.70265133
91IKBKE0.70123314
92MAPKAPK30.69589309
93MAP2K40.68893342
94ARAF0.68585616
95SIK20.66692717
96ERN10.66450450
97DAPK30.65236464
98PIK3CA0.64534017
99PRKG20.63386185
100PRKAA10.63336343
101FGFR20.61263112
102RPS6KB10.60955932
103MAP2K60.60677268
104PLK20.60296232
105STK240.60135351
106OBSCN0.58661397
107MAP3K100.53832510
108TEC0.52354618
109EPHA40.52184491
110SGK4940.52177214
111SGK2230.52177214
112NEK60.51634604
113CDK80.50891921
114MTOR0.48318671
115MAP3K10.48045559
116PDK20.48033959
117SGK20.45072338
118TRPM70.44196572
119BMX0.43826993
120ABL20.43712997
121NEK90.43691447
122ERBB20.43217963
123LYN0.43132742
124VRK20.41751061
125PRKCE0.41443852
126PRKCD0.41379765
127MAPKAPK50.41370493
128KDR0.40978342
129MAP3K30.39811570
130MARK20.39735176
131TAOK10.39038071
132LATS10.37995608
133MYLK0.37895001
134TNIK0.37628352
135CAMK40.37349833
136IGF1R0.37344121
137PRKD30.37243103
138STK160.37175134
139STK110.36709548
140WNK30.35755580
141AKT20.35140906
142PRKACG0.35068732
143KSR20.34985546
144MAP3K70.34699656
145SRPK10.34144821
146FGFR30.32723251
147MAPK10.32601983
148ADRBK10.32260583
149ABL10.31475336
150EPHA20.31392835
151BLK0.31189945
152CSNK1E0.30913600
153MKNK20.30342425
154PTK60.30122857
155CAMK2A0.30121313
156PRKG10.30053597
157MAP3K60.29970909
158CHUK0.28736067
159CAMK10.27349701
160STK30.26558189
161CAMKK10.25800004
162SGK10.25320882
163PRKCZ0.24050958
164EPHA30.23870083
165STK38L0.23829108
166PRKCH0.22016760
167PRKACA0.21943498
168MAPK30.21770028
169RPS6KA40.21474589
170FGR0.20947813
171MAPK120.20128068
172MAPK90.19677252
173MOS0.19331366
174KIT0.18954493
175INSR0.17787956

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.61704417
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.58621827
3Collecting duct acid secretion_Homo sapiens_hsa049663.56223384
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.89328429
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.66227372
6Rheumatoid arthritis_Homo sapiens_hsa053232.47536244
7Leishmaniasis_Homo sapiens_hsa051402.29221984
8Graft-versus-host disease_Homo sapiens_hsa053322.28394472
9Vitamin digestion and absorption_Homo sapiens_hsa049772.26944698
10PPAR signaling pathway_Homo sapiens_hsa033202.20111122
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17071751
12Arginine biosynthesis_Homo sapiens_hsa002202.16377351
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.12808314
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12024536
15Type I diabetes mellitus_Homo sapiens_hsa049402.09301836
16Sulfur relay system_Homo sapiens_hsa041222.00678222
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92841559
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.90094763
19Legionellosis_Homo sapiens_hsa051341.89374075
20Pancreatic secretion_Homo sapiens_hsa049721.87865732
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.83585021
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82254933
23Fat digestion and absorption_Homo sapiens_hsa049751.77955041
24Arginine and proline metabolism_Homo sapiens_hsa003301.75099930
25Phenylalanine metabolism_Homo sapiens_hsa003601.74193564
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71913537
27Histidine metabolism_Homo sapiens_hsa003401.68439995
28Tuberculosis_Homo sapiens_hsa051521.59226401
29Nicotine addiction_Homo sapiens_hsa050331.56868727
30Fatty acid degradation_Homo sapiens_hsa000711.54357081
31Phagosome_Homo sapiens_hsa041451.51130521
32Arachidonic acid metabolism_Homo sapiens_hsa005901.50857554
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48365568
34One carbon pool by folate_Homo sapiens_hsa006701.47990171
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47083615
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44251861
37Renin-angiotensin system_Homo sapiens_hsa046141.43414239
38Protein digestion and absorption_Homo sapiens_hsa049741.42487129
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.41181207
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40632927
41TNF signaling pathway_Homo sapiens_hsa046681.39471848
42Fatty acid metabolism_Homo sapiens_hsa012121.37326306
43Ether lipid metabolism_Homo sapiens_hsa005651.36601021
44Linoleic acid metabolism_Homo sapiens_hsa005911.36581828
45Bile secretion_Homo sapiens_hsa049761.32983395
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32431876
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31885728
48Fatty acid elongation_Homo sapiens_hsa000621.31759864
49ABC transporters_Homo sapiens_hsa020101.30261303
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29609620
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28026083
52Other glycan degradation_Homo sapiens_hsa005111.27098123
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24582272
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24495204
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21607552
56Tyrosine metabolism_Homo sapiens_hsa003501.19881244
57Allograft rejection_Homo sapiens_hsa053301.19217929
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17809098
59Malaria_Homo sapiens_hsa051441.15805831
60Staphylococcus aureus infection_Homo sapiens_hsa051501.14307366
61Hepatitis B_Homo sapiens_hsa051611.12262957
62Fatty acid biosynthesis_Homo sapiens_hsa000611.11919969
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10648746
64Pyruvate metabolism_Homo sapiens_hsa006201.10143963
65N-Glycan biosynthesis_Homo sapiens_hsa005101.07976025
66Pertussis_Homo sapiens_hsa051331.06152987
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04492605
68Salmonella infection_Homo sapiens_hsa051321.02635873
69African trypanosomiasis_Homo sapiens_hsa051431.00503144
70Regulation of autophagy_Homo sapiens_hsa041401.00145324
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00127093
72Ovarian steroidogenesis_Homo sapiens_hsa049130.97752237
73Axon guidance_Homo sapiens_hsa043600.95912085
74Osteoclast differentiation_Homo sapiens_hsa043800.95615379
75Influenza A_Homo sapiens_hsa051640.95327318
76Hematopoietic cell lineage_Homo sapiens_hsa046400.94441956
77Starch and sucrose metabolism_Homo sapiens_hsa005000.94303275
78Peroxisome_Homo sapiens_hsa041460.92479131
79Propanoate metabolism_Homo sapiens_hsa006400.89039337
80Butanoate metabolism_Homo sapiens_hsa006500.88411026
81Taste transduction_Homo sapiens_hsa047420.86777982
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85294726
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85279708
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83701685
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81287381
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80693838
87Measles_Homo sapiens_hsa051620.80211718
88Lysosome_Homo sapiens_hsa041420.80149443
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79907194
90Lysine degradation_Homo sapiens_hsa003100.79494807
91Glutathione metabolism_Homo sapiens_hsa004800.79177448
92Oxytocin signaling pathway_Homo sapiens_hsa049210.79172478
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78740019
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.78246866
95Notch signaling pathway_Homo sapiens_hsa043300.76128156
96Dorso-ventral axis formation_Homo sapiens_hsa043200.76054787
97Fructose and mannose metabolism_Homo sapiens_hsa000510.74731606
98Asthma_Homo sapiens_hsa053100.74696454
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74687044
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.74660380
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74020069
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73512135
103Synaptic vesicle cycle_Homo sapiens_hsa047210.72624981
104Olfactory transduction_Homo sapiens_hsa047400.70651442
105Chemokine signaling pathway_Homo sapiens_hsa040620.69894435
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.69692726
107Chemical carcinogenesis_Homo sapiens_hsa052040.68868255
108Biosynthesis of amino acids_Homo sapiens_hsa012300.66831639
109Steroid biosynthesis_Homo sapiens_hsa001000.63984836
110Glutamatergic synapse_Homo sapiens_hsa047240.63976251
111Sphingolipid metabolism_Homo sapiens_hsa006000.62441293
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61802977
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61339788
114beta-Alanine metabolism_Homo sapiens_hsa004100.61026297
115Carbon metabolism_Homo sapiens_hsa012000.60308683
116Mineral absorption_Homo sapiens_hsa049780.58777273
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58649383
118Herpes simplex infection_Homo sapiens_hsa051680.58062000
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57765065
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57422340
121Morphine addiction_Homo sapiens_hsa050320.57124416
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55632483
123Vitamin B6 metabolism_Homo sapiens_hsa007500.54619204
124Ras signaling pathway_Homo sapiens_hsa040140.53120240
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52823407
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51863643
127Insulin resistance_Homo sapiens_hsa049310.51665282
128Wnt signaling pathway_Homo sapiens_hsa043100.51087806
129Thyroid hormone synthesis_Homo sapiens_hsa049180.49276168
130Serotonergic synapse_Homo sapiens_hsa047260.47192348
131Metabolic pathways_Homo sapiens_hsa011000.46344373
132Galactose metabolism_Homo sapiens_hsa000520.45937054
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44532047
134Platelet activation_Homo sapiens_hsa046110.44525808
135Apoptosis_Homo sapiens_hsa042100.44310953
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.44064930
137Melanoma_Homo sapiens_hsa052180.43807409
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.43018577
139Basal cell carcinoma_Homo sapiens_hsa052170.41262492
140Calcium signaling pathway_Homo sapiens_hsa040200.40863930
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40859216
142Gastric acid secretion_Homo sapiens_hsa049710.40232459
143Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39842441
144Tryptophan metabolism_Homo sapiens_hsa003800.39707165
145Retinol metabolism_Homo sapiens_hsa008300.39482357
146Rap1 signaling pathway_Homo sapiens_hsa040150.39081108
147Circadian rhythm_Homo sapiens_hsa047100.38102802
148Autoimmune thyroid disease_Homo sapiens_hsa053200.36997413
149TGF-beta signaling pathway_Homo sapiens_hsa043500.36620929
150Long-term depression_Homo sapiens_hsa047300.36400363
151Vibrio cholerae infection_Homo sapiens_hsa051100.35567053
152Fanconi anemia pathway_Homo sapiens_hsa034600.35461971
153MAPK signaling pathway_Homo sapiens_hsa040100.34777956
154Oxidative phosphorylation_Homo sapiens_hsa001900.33899626
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33565620
156Prion diseases_Homo sapiens_hsa050200.33329022
157Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32890413
158HTLV-I infection_Homo sapiens_hsa051660.31851197
159Amoebiasis_Homo sapiens_hsa051460.31426248
160Glycerolipid metabolism_Homo sapiens_hsa005610.31218499
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.30541161
162Insulin signaling pathway_Homo sapiens_hsa049100.29962563
163Glucagon signaling pathway_Homo sapiens_hsa049220.28422196
164AMPK signaling pathway_Homo sapiens_hsa041520.27854344
165ECM-receptor interaction_Homo sapiens_hsa045120.27359930
166Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27071247
167Sulfur metabolism_Homo sapiens_hsa009200.25175790
168Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23153382
169mTOR signaling pathway_Homo sapiens_hsa041500.11961918

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