TRIM51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K9 demethylation (GO:0033169)9.48057041
2tyrosine metabolic process (GO:0006570)8.79555281
3regulation of cytokine production involved in inflammatory response (GO:1900015)7.38916223
4melanocyte differentiation (GO:0030318)7.19812396
5pigment cell differentiation (GO:0050931)7.16682605
6negative regulation of macroautophagy (GO:0016242)6.13294076
7developmental pigmentation (GO:0048066)6.02025188
8cGMP-mediated signaling (GO:0019934)6.00083972
9enteric nervous system development (GO:0048484)5.93860335
10regulation of penile erection (GO:0060405)5.78456362
11negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)5.76893226
12regulation of uterine smooth muscle contraction (GO:0070472)5.19877346
13response to pheromone (GO:0019236)5.10512224
14response to methylmercury (GO:0051597)4.83697694
15neuroepithelial cell differentiation (GO:0060563)4.79489960
16acrosome reaction (GO:0007340)4.73108026
17phenol-containing compound biosynthetic process (GO:0046189)4.56290978
18negative regulation of focal adhesion assembly (GO:0051895)4.46683089
19negative regulation of cell junction assembly (GO:1901889)4.46683089
20negative regulation of adherens junction organization (GO:1903392)4.46683089
21pigmentation (GO:0043473)4.35935705
22endosome to melanosome transport (GO:0035646)4.25319561
23endosome to pigment granule transport (GO:0043485)4.25319561
24phasic smooth muscle contraction (GO:0014821)4.20809254
25oocyte development (GO:0048599)4.09975517
26regulation of exit from mitosis (GO:0007096)4.05477284
27melanosome organization (GO:0032438)4.02041353
28proteasome assembly (GO:0043248)3.96002180
29regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.95633880
30peripheral nervous system development (GO:0007422)3.85165662
31negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.82587120
32pigment granule organization (GO:0048753)3.80411432
33regulation of acrosome reaction (GO:0060046)3.74588377
34astrocyte differentiation (GO:0048708)3.71803201
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.67904032
36termination of RNA polymerase III transcription (GO:0006386)3.67904032
37axon regeneration (GO:0031103)3.66341839
38regulation of heat generation (GO:0031650)3.64919361
39positive regulation of uterine smooth muscle contraction (GO:0070474)3.64193482
40regulation of lipoprotein metabolic process (GO:0050746)3.60058099
41negative regulation of response to extracellular stimulus (GO:0032105)3.54797675
42negative regulation of response to nutrient levels (GO:0032108)3.54797675
43neural crest cell migration (GO:0001755)3.54361894
44histone lysine demethylation (GO:0070076)3.53819923
45long-chain fatty acid biosynthetic process (GO:0042759)3.53626441
46synaptonemal complex organization (GO:0070193)3.50884378
47fusion of sperm to egg plasma membrane (GO:0007342)3.49413309
48positive regulation of neuroblast proliferation (GO:0002052)3.48983158
49multicellular organism reproduction (GO:0032504)3.46756227
50histone demethylation (GO:0016577)3.44527512
51platelet dense granule organization (GO:0060155)3.41426749
52positive regulation of meiosis (GO:0045836)3.38064987
53phagocytosis, recognition (GO:0006910)3.36113339
54positive regulation of catecholamine secretion (GO:0033605)3.35491095
55axon development (GO:0061564)3.35005008
56sialylation (GO:0097503)3.31707444
57positive regulation of meiotic cell cycle (GO:0051446)3.22179525
58regulation of fever generation (GO:0031620)3.21425323
59calcium ion-dependent exocytosis (GO:0017156)3.19658166
60aromatic amino acid family metabolic process (GO:0009072)3.19597810
61synaptonemal complex assembly (GO:0007130)3.19282784
62protein demethylation (GO:0006482)3.15770395
63protein dealkylation (GO:0008214)3.15770395
64positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.13235654
65neuron remodeling (GO:0016322)3.04829848
66secretory granule organization (GO:0033363)2.99651717
67protein K6-linked ubiquitination (GO:0085020)2.97332481
68pigment biosynthetic process (GO:0046148)2.92407662
69negative regulation of autophagy (GO:0010507)2.90384162
70secondary metabolic process (GO:0019748)2.89212612
71regulation of neuroblast proliferation (GO:1902692)2.88467555
72protein kinase C signaling (GO:0070528)2.86723663
73positive regulation of macrophage cytokine production (GO:0060907)2.85786458
74osteoclast differentiation (GO:0030316)2.84894059
75hyaluronan catabolic process (GO:0030214)2.84694300
76bone remodeling (GO:0046849)2.84596022
77transcription from mitochondrial promoter (GO:0006390)2.84296598
78regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.79446717
79regulation of sensory perception of pain (GO:0051930)2.76451891
80regulation of sensory perception (GO:0051931)2.76451891
81plasma membrane fusion (GO:0045026)2.71264606
82semaphorin-plexin signaling pathway (GO:0071526)2.71153424
83pyrimidine dimer repair (GO:0006290)2.71004445
84regulation of macroautophagy (GO:0016241)2.69609001
85negative regulation of norepinephrine secretion (GO:0010700)2.69066375
86purine ribonucleotide transport (GO:0015868)2.68141414
87regulation of DNA endoreduplication (GO:0032875)2.67396449
88embryonic body morphogenesis (GO:0010172)2.67250863
89UDP-N-acetylglucosamine metabolic process (GO:0006047)2.66014111
90keratan sulfate biosynthetic process (GO:0018146)2.65532011
91branching involved in prostate gland morphogenesis (GO:0060442)2.64270725
92negative regulation of Ras GTPase activity (GO:0034261)2.61964407
93keratan sulfate metabolic process (GO:0042339)2.60570663
94basement membrane organization (GO:0071711)2.54709737
95columnar/cuboidal epithelial cell differentiation (GO:0002065)2.54586395
96negative regulation of retinoic acid receptor signaling pathway (GO:0048387)13.1240293
97melanin biosynthetic process (GO:0042438)12.2507221
98melanin metabolic process (GO:0006582)11.1683145
99regulation of retinoic acid receptor signaling pathway (GO:0048385)10.6652649
100secondary metabolite biosynthetic process (GO:0044550)10.3162820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human8.17915983
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.79782161
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.84554705
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.09897814
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.05048361
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68390016
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.63364449
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59300632
9SOX9_26525672_Chip-Seq_Limbbuds_Mouse2.39009781
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09411651
11AR_21572438_ChIP-Seq_LNCaP_Human2.03764962
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96932474
13CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94110362
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.93228181
15MITF_21258399_ChIP-Seq_MELANOMA_Human1.85423947
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84498091
17IGF1R_20145208_ChIP-Seq_DFB_Human1.82817244
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78847868
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.75075373
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72311157
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69546032
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.69050834
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.63115645
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63096209
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58880897
26TCF4_23295773_ChIP-Seq_U87_Human1.58039664
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55796490
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55796490
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55796490
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54138337
31MYC_18940864_ChIP-ChIP_HL60_Human1.51070094
32AR_21909140_ChIP-Seq_LNCAP_Human1.48758144
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44702891
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.43522319
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42407379
36STAT3_23295773_ChIP-Seq_U87_Human1.40199363
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37307424
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37071748
39SMAD4_21799915_ChIP-Seq_A2780_Human1.32808558
40EZH2_22144423_ChIP-Seq_EOC_Human1.32402444
41P300_19829295_ChIP-Seq_ESCs_Human1.32227812
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31325314
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30417396
44RNF2_27304074_Chip-Seq_NSC_Mouse1.29576393
45VDR_22108803_ChIP-Seq_LS180_Human1.29315287
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28417921
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28162606
48ZNF274_21170338_ChIP-Seq_K562_Hela1.27835154
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.27271696
50SMAD4_21741376_ChIP-Seq_HESCs_Human1.22981440
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22463640
52VDR_24787735_ChIP-Seq_THP-1_Human1.18317708
53AR_25329375_ChIP-Seq_VCAP_Human1.15479102
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.15089626
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14991998
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14799994
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14287857
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13596433
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13174021
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.12962166
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10916583
62IRF1_19129219_ChIP-ChIP_H3396_Human1.09541931
63RUNX2_22187159_ChIP-Seq_PCA_Human1.07992565
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07022537
65GF1B_26923725_Chip-Seq_HPCs_Mouse1.06966882
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05849668
67TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05374247
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.04824150
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.04401552
70TCF4_22108803_ChIP-Seq_LS180_Human1.03341430
71GBX2_23144817_ChIP-Seq_PC3_Human0.97339735
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97288946
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96177473
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96137725
75SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96129565
76CJUN_26792858_Chip-Seq_BT549_Human0.96002617
77NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95743055
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95743055
79FLI1_21867929_ChIP-Seq_TH2_Mouse0.95286088
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94705065
81KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93681614
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93490188
83SOX9_26525672_Chip-Seq_HEART_Mouse0.92550916
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92374027
85GF1_26923725_Chip-Seq_HPCs_Mouse0.91170286
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90650075
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.89610844
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89151077
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89025966
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.88403625
91NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87653846
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87517115
93TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.87206624
94NCOR_22424771_ChIP-Seq_293T_Human0.86652748
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86389973
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86308901
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85734882
98BCAT_22108803_ChIP-Seq_LS180_Human0.85701485
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84066281
100JUN_21703547_ChIP-Seq_K562_Human0.83407608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation9.98402892
2MP0003136_yellow_coat_color7.16457548
3MP0000569_abnormal_digit_pigmentation6.79922608
4MP0000015_abnormal_ear_pigmentation5.89049246
5MP0005408_hypopigmentation5.32598584
6MP0005174_abnormal_tail_pigmentation5.18634455
7MP0000372_irregular_coat_pigmentation4.97902565
8MP0004381_abnormal_hair_follicle4.53391749
9MP0005075_abnormal_melanosome_morpholog4.16934908
10MP0002095_abnormal_skin_pigmentation3.70717988
11MP0005257_abnormal_intraocular_pressure2.88797915
12MP0000371_diluted_coat_color2.64173341
13MP0002877_abnormal_melanocyte_morpholog2.57435267
14MP0002938_white_spotting2.31594397
15MP0002075_abnormal_coat/hair_pigmentati1.91877283
16MP0001324_abnormal_eye_pigmentation1.77459258
17MP0001186_pigmentation_phenotype1.65419877
18MP0005248_abnormal_Harderian_gland1.39990484
19MP0005670_abnormal_white_adipose1.30800765
20MP0003283_abnormal_digestive_organ1.14622074
21MP0005058_abnormal_lysosome_morphology1.11742120
22MP0002638_abnormal_pupillary_reflex1.04501149
23MP0003172_abnormal_lysosome_physiology1.01050215
24MP0003950_abnormal_plasma_membrane0.95663005
25MP0003718_maternal_effect0.93496917
26MP0005197_abnormal_uvea_morphology0.90738332
27MP0002177_abnormal_outer_ear0.88140769
28MP0002751_abnormal_autonomic_nervous0.86433564
29MP0002090_abnormal_vision0.83866773
30MP0009840_abnormal_foam_cell0.69308111
31MP0006292_abnormal_olfactory_placode0.62762282
32MP0010094_abnormal_chromosome_stability0.62707531
33MP0009379_abnormal_foot_pigmentation0.56157545
34MP0002822_catalepsy0.55238947
35MP0008438_abnormal_cutaneous_collagen0.53256093
36MP0000427_abnormal_hair_cycle0.52912114
37MP0002229_neurodegeneration0.52792857
38MP0004742_abnormal_vestibular_system0.50749580
39MP0009046_muscle_twitch0.48950430
40MP0005253_abnormal_eye_physiology0.48909021
41MP0003693_abnormal_embryo_hatching0.48526063
42MP0000749_muscle_degeneration0.45626220
43MP0002102_abnormal_ear_morphology0.44993085
44MP0001293_anophthalmia0.43877820
45MP0008932_abnormal_embryonic_tissue0.43627170
46MP0005220_abnormal_exocrine_pancreas0.42413987
47MP0001502_abnormal_circadian_rhythm0.40849528
48MP0003077_abnormal_cell_cycle0.40808514
49MP0004272_abnormal_basement_membrane0.39632228
50MP0001485_abnormal_pinna_reflex0.39469283
51MP0001851_eye_inflammation0.36470701
52MP0002160_abnormal_reproductive_system0.35187320
53MP0003634_abnormal_glial_cell0.34284134
54MP0000920_abnormal_myelination0.34079223
55MP0001929_abnormal_gametogenesis0.33594605
56MP0003186_abnormal_redox_activity0.33321994
57MP0000377_abnormal_hair_follicle0.32601873
58MP0000367_abnormal_coat/_hair0.31661858
59MP0005395_other_phenotype0.31588534
60MP0002067_abnormal_sensory_capabilities0.29788976
61MP0005551_abnormal_eye_electrophysiolog0.28937267
62MP0004043_abnormal_pH_regulation0.28728005
63MP0002653_abnormal_ependyma_morphology0.28117268
64MP0008058_abnormal_DNA_repair0.27122329
65MP0002210_abnormal_sex_determination0.26778803
66MP0005193_abnormal_anterior_eye0.26461655
67MP0000647_abnormal_sebaceous_gland0.25782422
68MP0002269_muscular_atrophy0.25767571
69MP0001664_abnormal_digestion0.25449204
70MP0003195_calcinosis0.24622142
71MP0005410_abnormal_fertilization0.24513642
72MP0003699_abnormal_female_reproductive0.24194449
73MP0005195_abnormal_posterior_eye0.24001179
74MP0008770_decreased_survivor_rate0.22968664
75MP0005508_abnormal_skeleton_morphology0.22605318
76MP0002837_dystrophic_cardiac_calcinosis0.22162596
77MP0003890_abnormal_embryonic-extraembry0.22091201
78MP0002272_abnormal_nervous_system0.21830124
79MP0002396_abnormal_hematopoietic_system0.21712527
80MP0009384_cardiac_valve_regurgitation0.21267335
81MP0003632_abnormal_nervous_system0.20936902
82MP0003698_abnormal_male_reproductive0.20502794
83MP0008260_abnormal_autophagy0.20147217
84MP0008569_lethality_at_weaning0.19503274
85MP0002161_abnormal_fertility/fecundity0.19480181
86MP0000358_abnormal_cell_content/0.19439481
87MP0006276_abnormal_autonomic_nervous0.18458838
88MP0003111_abnormal_nucleus_morphology0.18368154
89MP0005379_endocrine/exocrine_gland_phen0.17713461
90MP0000778_abnormal_nervous_system0.15939837
91MP0002557_abnormal_social/conspecific_i0.15483581
92MP0002064_seizures0.15337114
93MP0000350_abnormal_cell_proliferation0.14404496
94MP0001963_abnormal_hearing_physiology0.14152321
95MP0004233_abnormal_muscle_weight0.13457554
96MP0000653_abnormal_sex_gland0.13419479
97MP0009745_abnormal_behavioral_response0.11464293
98MP0003690_abnormal_glial_cell0.11223076
99MP0002752_abnormal_somatic_nervous0.11192770
100MP0001905_abnormal_dopamine_level0.11090428

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the fovea (HP:0007750)7.84330674
2Aplasia/Hypoplasia of the fovea (HP:0008060)7.84330674
3Albinism (HP:0001022)7.61900601
4Blue irides (HP:0000635)7.35605176
5Aplasia/Hypoplasia of the macula (HP:0008059)7.25136541
6Congenital sensorineural hearing impairment (HP:0008527)6.76204487
7Aplasia/Hypoplasia affecting the retina (HP:0008061)6.73206314
8Heterochromia iridis (HP:0001100)6.53967811
9Generalized hypopigmentation (HP:0007513)6.47566091
10Ocular albinism (HP:0001107)6.39695247
11Abnormality of the fovea (HP:0000493)6.20986441
12Premature graying of hair (HP:0002216)6.12418743
13Abnormal auditory evoked potentials (HP:0006958)6.00414338
14Hypoplasia of the iris (HP:0007676)5.59518111
15Iris hypopigmentation (HP:0007730)5.59049346
16Cutaneous melanoma (HP:0012056)4.14797444
17Peripheral hypomyelination (HP:0007182)3.88053326
18Hypopigmentation of the fundus (HP:0007894)3.84089352
19Upper limb muscle weakness (HP:0003484)3.58104482
20Bilateral sensorineural hearing impairment (HP:0008619)3.48916848
21Spastic paraparesis (HP:0002313)3.46606625
22Generalized hypopigmentation of hair (HP:0011358)3.36534114
23Spinal muscular atrophy (HP:0007269)2.79590975
24Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.75300937
25Large for gestational age (HP:0001520)2.73843046
26Paraparesis (HP:0002385)2.73600756
27Ulnar claw (HP:0001178)2.66523731
28Underdeveloped nasal alae (HP:0000430)2.59968988
29Synophrys (HP:0000664)2.55330870
30Abnormality of the anterior horn cell (HP:0006802)2.45646656
31Degeneration of anterior horn cells (HP:0002398)2.45646656
32Follicular hyperkeratosis (HP:0007502)2.37049540
33Cerebral hypomyelination (HP:0006808)2.32502299
34Premature ovarian failure (HP:0008209)2.28258453
35Facial cleft (HP:0002006)2.21262146
36Action tremor (HP:0002345)2.11508320
37Neurofibrillary tangles (HP:0002185)2.07302511
38White forelock (HP:0002211)12.3277863
39Patchy hypopigmentation of hair (HP:0011365)11.5235369
40Loss of speech (HP:0002371)1.98886939
41Abnormality of the nasal septum (HP:0000419)1.97415339
42J-shaped sella turcica (HP:0002680)1.91673297
43Adrenal hypoplasia (HP:0000835)1.89238086
44Median cleft lip (HP:0000161)1.87777133
45Abnormal pupillary function (HP:0007686)1.87516688
46Hypokinesia (HP:0002375)1.82730644
47Submucous cleft hard palate (HP:0000176)1.80542873
48Insidious onset (HP:0003587)1.79106303
49Termporal pattern (HP:0011008)1.79106303
50Abnormal autonomic nervous system physiology (HP:0012332)1.77609514
51Freckling (HP:0001480)1.74244705
52Entropion (HP:0000621)1.74047439
53Lip pit (HP:0100267)1.71007375
54Sparse eyelashes (HP:0000653)1.69223671
55Decreased motor nerve conduction velocity (HP:0003431)1.65591907
56Abnormality of glycolysis (HP:0004366)1.64065336
57Hand muscle atrophy (HP:0009130)1.59778762
58Blepharitis (HP:0000498)1.59314814
59Morphological abnormality of the middle ear (HP:0008609)1.58790629
60Cerebral inclusion bodies (HP:0100314)1.53972723
61Concave nail (HP:0001598)1.52688724
62Alopecia of scalp (HP:0002293)1.51769761
63Diaphragmatic weakness (HP:0009113)1.49559350
64Abnormal umbilical cord blood vessels (HP:0011403)1.48278003
65Single umbilical artery (HP:0001195)1.48278003
66Abnormality of the fetal cardiovascular system (HP:0010948)1.48278003
67Increased serum pyruvate (HP:0003542)1.47974494
68Stridor (HP:0010307)1.47936856
69Aganglionic megacolon (HP:0002251)1.46961335
70Morphological abnormality of the inner ear (HP:0011390)1.45337941
71Gaze-evoked nystagmus (HP:0000640)1.42788098
72Neurodegeneration (HP:0002180)1.41437392
73Short tibia (HP:0005736)1.41393849
74Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.40047344
75Postural tremor (HP:0002174)1.38926682
76Aplasia/Hypoplasia of the tibia (HP:0005772)1.38433182
77Abnormality of the corticospinal tract (HP:0002492)1.36929796
78Lower limb hyperreflexia (HP:0002395)1.33856854
79Abnormality of alanine metabolism (HP:0010916)1.33813859
80Hyperalaninemia (HP:0003348)1.33813859
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.33813859
82Photophobia (HP:0000613)1.32982249
83Increased mean platelet volume (HP:0011877)1.30663035
84Abnormal number of incisors (HP:0011064)1.29351481
85Melanoma (HP:0002861)1.28438345
86Impaired proprioception (HP:0010831)1.28239674
87Abnormality of dental color (HP:0011073)1.26420288
88Degeneration of the lateral corticospinal tracts (HP:0002314)1.26406140
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.26406140
90Foot dorsiflexor weakness (HP:0009027)1.24792065
91Dysdiadochokinesis (HP:0002075)1.24370970
92Distal upper limb amyotrophy (HP:0007149)1.23580253
93Upper limb amyotrophy (HP:0009129)1.23580253
94Progressive inability to walk (HP:0002505)1.19880032
95Aplasia cutis congenita (HP:0001057)1.19619218
96Tongue fasciculations (HP:0001308)1.17726004
97Tetraparesis (HP:0002273)1.17466754
98Decreased lacrimation (HP:0000633)1.16863269
99Peripheral demyelination (HP:0011096)1.15766202
100Flared iliac wings (HP:0002869)1.15666943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK35.76987556
2FER4.10568816
3PDK23.43140892
4PAK33.18255560
5MAPKAPK53.09892446
6PRKD33.02422047
7MKNK12.94451064
8DDR22.87444989
9STK162.79284486
10LMTK22.58881809
11WEE12.39791102
12ICK2.36222268
13CDK192.13421256
14BUB11.96038709
15MAPKAPK31.89902643
16CCNB11.88778565
17FGFR11.87792464
18MAP3K31.84353163
19NME21.75409572
20GSK3A1.72883223
21PRKCI1.62190254
22TNIK1.55073954
23MAP2K11.51654497
24BRAF1.51461374
25TRIM281.39696696
26BRSK21.35715104
27MAPK131.34362106
28PKN11.34298584
29PTK21.33142373
30PRKD11.32341456
31PIM21.27589950
32NUAK11.26640009
33TTK1.25809531
34NEK61.25194426
35PAK11.24165461
36PLK21.12100804
37ERBB41.05131255
38LATS10.99774899
39TAOK30.98838013
40PLK30.95868456
41BRSK10.94899696
42PAK60.91139619
43PLK40.89949223
44LATS20.87148638
45PBK0.85098219
46ARAF0.83981163
47OXSR10.79484780
48CHEK20.79410659
49CSNK1G20.78352696
50VRK20.77777296
51CDK120.77395127
52TYRO30.70534901
53STK390.66605184
54DMPK0.66458949
55LIMK10.63657122
56ABL20.63428883
57RPS6KA50.60991490
58TSSK60.60728399
59PRKACB0.59353822
60AURKA0.57534571
61PNCK0.57355247
62PLK10.54528578
63ACVR1B0.49974467
64PTK2B0.49525213
65CDK70.49434393
66STK30.47445172
67MAP2K30.47082525
68MAPK120.46872157
69NEK20.46807206
70BMPR1B0.45758833
71VRK10.45563493
72WNK40.39871614
73INSRR0.38589815
74PDGFRB0.37981739
75CDK30.37205825
76MOS0.36932998
77RAF10.35924379
78ERBB20.35796014
79AKT20.35627245
80TESK20.35405738
81MAPKAPK20.34470433
82AURKB0.33414049
83NLK0.33025862
84PIK3CA0.32786205
85EPHA40.32498527
86CHEK10.31891682
87EEF2K0.30298671
88SIK30.30073592
89TLK10.28987664
90ADRBK10.28106541
91CDK11A0.27144339
92IGF1R0.26880957
93ABL10.25689478
94CAMK2A0.25105018
95ERBB30.24719880
96CSNK1G10.24413907
97CSNK2A10.19319384
98ATR0.19304478
99CDK180.19223423
100NEK10.18276564

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.95722865
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.58950598
3Tyrosine metabolism_Homo sapiens_hsa003503.53780052
4Proteasome_Homo sapiens_hsa030503.24819892
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76995504
6Non-homologous end-joining_Homo sapiens_hsa034502.57861395
7Linoleic acid metabolism_Homo sapiens_hsa005912.51791167
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39654576
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.38085401
10Dorso-ventral axis formation_Homo sapiens_hsa043202.36575768
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.36046043
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.18798505
13Basal transcription factors_Homo sapiens_hsa030222.11571948
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02082088
15Folate biosynthesis_Homo sapiens_hsa007902.00405198
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.94663056
17Other glycan degradation_Homo sapiens_hsa005111.84535057
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.84290354
19ECM-receptor interaction_Homo sapiens_hsa045121.79648794
20RNA polymerase_Homo sapiens_hsa030201.74056060
21Lysosome_Homo sapiens_hsa041421.70286323
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.58791274
23Melanogenesis_Homo sapiens_hsa049161.57603629
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.52192506
25Nitrogen metabolism_Homo sapiens_hsa009101.48169493
26Oocyte meiosis_Homo sapiens_hsa041141.44012755
27Homologous recombination_Homo sapiens_hsa034401.43272216
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42172073
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41854891
30Arachidonic acid metabolism_Homo sapiens_hsa005901.40402001
31N-Glycan biosynthesis_Homo sapiens_hsa005101.40366130
32Ribosome_Homo sapiens_hsa030101.39325982
33Ovarian steroidogenesis_Homo sapiens_hsa049131.38987868
34Protein export_Homo sapiens_hsa030601.38329536
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.31757288
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30815636
37Fanconi anemia pathway_Homo sapiens_hsa034601.29258579
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18947623
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18624413
40Collecting duct acid secretion_Homo sapiens_hsa049661.14861060
41Ether lipid metabolism_Homo sapiens_hsa005651.14544888
42Starch and sucrose metabolism_Homo sapiens_hsa005001.05757447
43Phagosome_Homo sapiens_hsa041451.04041019
44Cell cycle_Homo sapiens_hsa041101.00174250
45Vitamin digestion and absorption_Homo sapiens_hsa049770.94694547
46Steroid biosynthesis_Homo sapiens_hsa001000.89624095
47Fatty acid biosynthesis_Homo sapiens_hsa000610.88137766
48Serotonergic synapse_Homo sapiens_hsa047260.86866813
49ABC transporters_Homo sapiens_hsa020100.85227116
50Sphingolipid metabolism_Homo sapiens_hsa006000.83470835
51RNA transport_Homo sapiens_hsa030130.82868421
52Mismatch repair_Homo sapiens_hsa034300.80684046
53Olfactory transduction_Homo sapiens_hsa047400.78647223
54Lysine degradation_Homo sapiens_hsa003100.76060413
55Shigellosis_Homo sapiens_hsa051310.75907310
56Sulfur metabolism_Homo sapiens_hsa009200.75854079
57Fat digestion and absorption_Homo sapiens_hsa049750.71378577
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69430886
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63391732
60Adherens junction_Homo sapiens_hsa045200.61747511
61Fatty acid elongation_Homo sapiens_hsa000620.61389060
62Sulfur relay system_Homo sapiens_hsa041220.61296674
63Pyrimidine metabolism_Homo sapiens_hsa002400.61066542
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60227170
65Bile secretion_Homo sapiens_hsa049760.57932661
66One carbon pool by folate_Homo sapiens_hsa006700.55606348
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55605068
68Calcium signaling pathway_Homo sapiens_hsa040200.54703629
69Vibrio cholerae infection_Homo sapiens_hsa051100.53410176
70RNA degradation_Homo sapiens_hsa030180.50856612
71Melanoma_Homo sapiens_hsa052180.50450886
72p53 signaling pathway_Homo sapiens_hsa041150.50045921
73mRNA surveillance pathway_Homo sapiens_hsa030150.49354938
74Propanoate metabolism_Homo sapiens_hsa006400.47532590
75Epstein-Barr virus infection_Homo sapiens_hsa051690.44161688
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42452092
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42352461
78Synaptic vesicle cycle_Homo sapiens_hsa047210.41515829
79Metabolic pathways_Homo sapiens_hsa011000.41493660
80Base excision repair_Homo sapiens_hsa034100.39554320
81Retinol metabolism_Homo sapiens_hsa008300.36754557
82Chemical carcinogenesis_Homo sapiens_hsa052040.34793080
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.34496432
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33729766
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30767353
86Purine metabolism_Homo sapiens_hsa002300.29229583
87Hippo signaling pathway_Homo sapiens_hsa043900.29200968
88Protein digestion and absorption_Homo sapiens_hsa049740.26903150
89Taste transduction_Homo sapiens_hsa047420.25131869
90Hedgehog signaling pathway_Homo sapiens_hsa043400.23849128
91Hematopoietic cell lineage_Homo sapiens_hsa046400.21046179
92Phototransduction_Homo sapiens_hsa047440.20792363
93Selenocompound metabolism_Homo sapiens_hsa004500.19866803
94Malaria_Homo sapiens_hsa051440.19521097
95Proteoglycans in cancer_Homo sapiens_hsa052050.16629442
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16437015
97Nucleotide excision repair_Homo sapiens_hsa034200.16319884
98MicroRNAs in cancer_Homo sapiens_hsa052060.16317942
99Regulation of autophagy_Homo sapiens_hsa041400.15935547
100PPAR signaling pathway_Homo sapiens_hsa033200.14346250

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