ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oocyte development (GO:0048599)	7.47954325
2	histone lysine demethylation (GO:0070076)	7.43362833
3	histone demethylation (GO:0016577)	7.02978501
4	regulation of RIG-I signaling pathway (GO:0039535)	6.55051240
5	regulation of exit from mitosis (GO:0007096)	6.31949759
6	protein dealkylation (GO:0008214)	6.30244914
7	protein demethylation (GO:0006482)	6.30244914
8	multicellular organism reproduction (GO:0032504)	5.96750560
9	synaptonemal complex organization (GO:0070193)	5.94412247
10	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.77752151
11	synaptonemal complex assembly (GO:0007130)	5.68592211
12	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	5.66603205
13	positive regulation of meiosis (GO:0045836)	5.41276220
14	negative regulation of Ras GTPase activity (GO:0034261)	5.32588299
15	male meiosis I (GO:0007141)	5.22169095
16	gonadal mesoderm development (GO:0007506)	5.21902311
17	positive regulation of meiotic cell cycle (GO:0051446)	5.19569258
18	positive regulation of catecholamine secretion (GO:0033605)	5.08156565
19	regulation of acrosome reaction (GO:0060046)	4.99408839
20	N-terminal protein amino acid acetylation (GO:0006474)	4.91240144
21	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.83821553
22	protein K48-linked deubiquitination (GO:0071108)	4.63695555
23	regulation of female receptivity (GO:0045924)	4.57683446
24	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	4.46398234
25	male meiosis (GO:0007140)	4.35558968
26	regulation of uterine smooth muscle contraction (GO:0070472)	4.32438271
27	response to UV-C (GO:0010225)	4.28187118
28	single fertilization (GO:0007338)	4.17185157
29	meiosis I (GO:0007127)	4.15337921
30	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.99036311
31	female mating behavior (GO:0060180)	3.88084138
32	reproduction (GO:0000003)	3.87601740
33	phosphate ion homeostasis (GO:0055062)	3.84738381
34	trivalent inorganic anion homeostasis (GO:0072506)	3.84738381
35	acrosome reaction (GO:0007340)	3.81960498
36	positive regulation of humoral immune response (GO:0002922)	3.80721916
37	binding of sperm to zona pellucida (GO:0007339)	3.63857965
38	protein kinase C signaling (GO:0070528)	3.59307539
39	protein K63-linked deubiquitination (GO:0070536)	3.55981036
40	positive regulation of digestive system process (GO:0060456)	3.49749086
41	hyperosmotic salinity response (GO:0042538)	3.43715304
42	chromosome organization involved in meiosis (GO:0070192)	3.37474867
43	aggressive behavior (GO:0002118)	3.36001806
44	regulation of defense response to virus by host (GO:0050691)	3.32023045
45	positive regulation of histone H3-K4 methylation (GO:0051571)	3.29563613
46	sleep (GO:0030431)	3.28803280
47	maternal behavior (GO:0042711)	3.25137146
48	urate metabolic process (GO:0046415)	3.24679398
49	citrulline biosynthetic process (GO:0019240)	3.20328846
50	regulation of ruffle assembly (GO:1900027)	3.19444856
51	demethylation (GO:0070988)	3.18550183
52	regulation of helicase activity (GO:0051095)	3.17623818
53	striated muscle atrophy (GO:0014891)	3.14117325
54	fertilization (GO:0009566)	3.12884188
55	regulation of histone H3-K9 methylation (GO:0051570)	3.11831442
56	natural killer cell differentiation (GO:0001779)	3.09005434
57	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.07143471
58	drinking behavior (GO:0042756)	3.06890085
59	intestinal epithelial cell development (GO:0060576)	3.05151458
60	piRNA metabolic process (GO:0034587)	3.03081224
61	detection of other organism (GO:0098543)	2.96670584
62	negative regulation of reproductive process (GO:2000242)	2.96165547
63	poly(A)+ mRNA export from nucleus (GO:0016973)	2.95725688
64	regulation of meiosis (GO:0040020)	2.93992642
65	detection of bacterium (GO:0016045)	2.89240263
66	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.86902203
67	cellular anion homeostasis (GO:0030002)	2.85825613
68	parental behavior (GO:0060746)	2.81873480
69	sperm-egg recognition (GO:0035036)	2.81263632
70	meiotic cell cycle process (GO:1903046)	2.80029297
71	negative regulation of digestive system process (GO:0060457)	2.79213714
72	mRNA transcription from RNA polymerase II promoter (GO:0042789)	2.75207861
73	negative regulation of histone modification (GO:0031057)	2.74649646
74	tachykinin receptor signaling pathway (GO:0007217)	2.73641623
75	transcription from mitochondrial promoter (GO:0006390)	2.71212129
76	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.69602104
77	regulation of DNA methylation (GO:0044030)	2.69120891
78	muscle atrophy (GO:0014889)	2.68950726
79	centriole replication (GO:0007099)	2.67726375
80	phospholipid scrambling (GO:0017121)	2.67255184
81	regulation of penile erection (GO:0060405)	2.65032073
82	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.64855439
83	protein K6-linked ubiquitination (GO:0085020)	2.64213700
84	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.63553826
85	intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)	2.63123228
86	RNA localization (GO:0006403)	2.59591135
87	peristalsis (GO:0030432)	2.54134397
88	maturation of SSU-rRNA (GO:0030490)	2.52752867
89	spermatid development (GO:0007286)	2.51554834
90	regulation of histone deacetylation (GO:0031063)	2.50319023
91	regulation of G0 to G1 transition (GO:0070316)	2.48503379
92	regulation of female gonad development (GO:2000194)	2.48397120
93	mitotic G2 DNA damage checkpoint (GO:0007095)	2.46279731
94	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.45071588
95	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.45071588
96	meiotic nuclear division (GO:0007126)	2.44736326
97	regulation of neurotransmitter uptake (GO:0051580)	2.44523841
98	histone H3-K9 demethylation (GO:0033169)	17.8901734
99	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	15.3974810
100	regulation of retinoic acid receptor signaling pathway (GO:0048385)	12.8413181

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	7.92725989
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.06528152
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.82766832
4	GATA1_22025678_ChIP-Seq_K562_Human	4.52816134
5	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.36543109
6	VDR_22108803_ChIP-Seq_LS180_Human	3.02764585
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.96657363
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.90717931
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.74541337
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.62610885
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.50061712
12	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.42756607
13	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.31443948
14	AUTS2_25519132_ChIP-Seq_293T-REX_Human	2.29202258
15	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.27637377
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.14913212
17	PRDM14_20953172_ChIP-Seq_ESCs_Human	2.07864281
18	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.00130272
19	RXR_22108803_ChIP-Seq_LS180_Human	1.99285292
20	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.92961559
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.87895011
22	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.87691296
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81135364
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.79440689
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64556863
26	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.63943548
27	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.62839461
28	SMRT_27268052_Chip-Seq_Bcells_Human	1.58851211
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57105207
30	GATA3_26560356_Chip-Seq_TH1_Human	1.55043970
31	CBP_21632823_ChIP-Seq_H3396_Human	1.55000652
32	NCOR_22424771_ChIP-Seq_293T_Human	1.54146603
33	TCF4_23295773_ChIP-Seq_U87_Human	1.53744928
34	STAT3_23295773_ChIP-Seq_U87_Human	1.49959324
35	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.49353192
36	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.48964497
37	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.47718481
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45523428
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44070594
40	MYB_26560356_Chip-Seq_TH2_Human	1.43449529
41	GATA3_26560356_Chip-Seq_TH2_Human	1.42397878
42	ZNF274_21170338_ChIP-Seq_K562_Hela	1.42126388
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.41359276
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40011908
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37880173
46	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.37355881
47	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.37298791
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35452136
49	GF1_26923725_Chip-Seq_HPCs_Mouse	1.31903612
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31538842
51	AR_25329375_ChIP-Seq_VCAP_Human	1.30991145
52	RAC3_21632823_ChIP-Seq_H3396_Human	1.29513760
53	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.29400583
54	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.25695281
55	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.23850013
56	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.23398995
57	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.23398995
58	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.23398995
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.23104531
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22333859
61	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.22285769
62	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21710606
63	BCAT_22108803_ChIP-Seq_LS180_Human	1.21609515
64	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.21590781
65	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.21368470
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.19547007
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.18212989
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15599620
69	P300_19829295_ChIP-Seq_ESCs_Human	1.14207892
70	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.13015381
71	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.06214707
72	VDR_24763502_ChIP-Seq_THP-1_Human	1.05619895
73	TP63_23658742_ChIP-Seq_EP156T_Human	1.04850373
74	GATA3_27048872_Chip-Seq_THYMUS_Human	1.04370042
75	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.04283017
76	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.03940219
77	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.00727168
78	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.99960727
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.99458006
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99125848
81	VDR_24787735_ChIP-Seq_THP-1_Human	0.98898227
82	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97291762
83	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96749095
84	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.95965115
85	KLF4_19829295_ChIP-Seq_ESCs_Human	0.95298908
86	VDR_21846776_ChIP-Seq_THP-1_Human	0.95009178
87	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92372306
88	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.90908968
89	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.90830692
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.90708880
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90187199
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.88817456
93	AR_21909140_ChIP-Seq_LNCAP_Human	0.88612329
94	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.86000617
95	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.85314501
96	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.83748455
97	MYB_26560356_Chip-Seq_TH1_Human	0.82254192
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.81779306
99	TP53_22573176_ChIP-Seq_HFKS_Human	0.81156017
100	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.79919031

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.60177552
2	MP0003283_abnormal_digestive_organ	4.68103890
3	MP0000678_abnormal_parathyroid_gland	3.89234506
4	MP0009379_abnormal_foot_pigmentation	3.38100906
5	MP0002160_abnormal_reproductive_system	3.28157332
6	MP0003693_abnormal_embryo_hatching	3.09658567
7	MP0009840_abnormal_foam_cell	2.88225815
8	MP0003136_yellow_coat_color	2.86962304
9	MP0005410_abnormal_fertilization	2.85297703
10	MP0003950_abnormal_plasma_membrane	2.84257573
11	MP0003183_abnormal_peptide_metabolism	2.79139022
12	MP0003866_abnormal_defecation	2.77648830
13	MP0000427_abnormal_hair_cycle	2.73906964
14	MP0001929_abnormal_gametogenesis	2.33908620
15	MP0005220_abnormal_exocrine_pancreas	2.25253843
16	MP0002277_abnormal_respiratory_mucosa	2.21067527
17	MP0006276_abnormal_autonomic_nervous	2.12196435
18	MP0001986_abnormal_taste_sensitivity	2.06270433
19	MP0005647_abnormal_sex_gland	1.92197799
20	MP0002210_abnormal_sex_determination	1.91155005
21	MP0001545_abnormal_hematopoietic_system	1.90346140
22	MP0005397_hematopoietic_system_phenotyp	1.90346140
23	MP0001664_abnormal_digestion	1.87318854
24	MP0008058_abnormal_DNA_repair	1.84641539
25	MP0005360_urolithiasis	1.80701621
26	MP0002396_abnormal_hematopoietic_system	1.76782976
27	MP0003699_abnormal_female_reproductive	1.75426299
28	MP0001502_abnormal_circadian_rhythm	1.70270164
29	MP0001666_abnormal_nutrient_absorption	1.67673414
30	MP0005389_reproductive_system_phenotype	1.66849560
31	MP0003724_increased_susceptibility_to	1.60618748
32	MP0003763_abnormal_thymus_physiology	1.46499941
33	MP0010307_abnormal_tumor_latency	1.46433631
34	MP0003828_pulmonary_edema	1.45169995
35	MP0008877_abnormal_DNA_methylation	1.43421860
36	MP0002751_abnormal_autonomic_nervous	1.41527318
37	MP0000470_abnormal_stomach_morphology	1.39327326
38	MP0003119_abnormal_digestive_system	1.38810418
39	MP0004381_abnormal_hair_follicle	1.37603280
40	MP0000653_abnormal_sex_gland	1.29941501
41	MP0002127_abnormal_cardiovascular_syste	1.26993260
42	MP0003698_abnormal_male_reproductive	1.26254474
43	MP0000049_abnormal_middle_ear	1.22148526
44	MP0003890_abnormal_embryonic-extraembry	1.18805279
45	MP0005671_abnormal_response_to	1.16997735
46	MP0001119_abnormal_female_reproductive	1.16663996
47	MP0003868_abnormal_feces_composition	1.15972382
48	MP0009333_abnormal_splenocyte_physiolog	1.15564313
49	MP0009765_abnormal_xenobiotic_induced	1.12365916
50	MP0010094_abnormal_chromosome_stability	1.09977498
51	MP0002161_abnormal_fertility/fecundity	1.07718503
52	MP0005310_abnormal_salivary_gland	1.03881205
53	MP0003077_abnormal_cell_cycle	1.03694725
54	MP0002332_abnormal_exercise_endurance	1.02923561
55	MP0001145_abnormal_male_reproductive	1.02848651
56	MP0002419_abnormal_innate_immunity	1.00893656
57	MP0001730_embryonic_growth_arrest	0.99774746
58	MP0005025_abnormal_response_to	0.98437236
59	MP0009785_altered_susceptibility_to	0.94042597
60	MP0004233_abnormal_muscle_weight	0.93086203
61	MP0003938_abnormal_ear_development	0.91346333
62	MP0001835_abnormal_antigen_presentation	0.90647653
63	MP0003936_abnormal_reproductive_system	0.90488964
64	MP0002405_respiratory_system_inflammati	0.89460684
65	MP0002693_abnormal_pancreas_physiology	0.89391758
66	MP0001440_abnormal_grooming_behavior	0.88980213
67	MP0000230_abnormal_systemic_arterial	0.88961030
68	MP0001800_abnormal_humoral_immune	0.85428464
69	MP0000685_abnormal_immune_system	0.84934004
70	MP0001819_abnormal_immune_cell	0.83916888
71	MP0005164_abnormal_response_to	0.83747969
72	MP0005334_abnormal_fat_pad	0.83311010
73	MP0002452_abnormal_antigen_presenting	0.83039913
74	MP0002420_abnormal_adaptive_immunity	0.82992054
75	MP0002723_abnormal_immune_serum	0.80504992
76	MP0000372_irregular_coat_pigmentation	0.79700459
77	MP0002229_neurodegeneration	0.77090868
78	MP0003718_maternal_effect	0.76330855
79	MP0003303_peritoneal_inflammation	0.76234782
80	MP0010155_abnormal_intestine_physiology	0.74999274
81	MP0005076_abnormal_cell_differentiation	0.74848481
82	MP0002132_abnormal_respiratory_system	0.73380790
83	MP0002163_abnormal_gland_morphology	0.72966018
84	MP0002138_abnormal_hepatobiliary_system	0.72382982
85	MP0003959_abnormal_lean_body	0.70577669
86	MP0005646_abnormal_pituitary_gland	0.70481689
87	MP0003436_decreased_susceptibility_to	0.70447304
88	MP0001501_abnormal_sleep_pattern	0.68821479
89	MP0001881_abnormal_mammary_gland	0.68757749
90	MP0000350_abnormal_cell_proliferation	0.66257525
91	MP0005645_abnormal_hypothalamus_physiol	0.65866846
92	MP0000689_abnormal_spleen_morphology	0.65026567
93	MP0002722_abnormal_immune_system	0.64625358
94	MP0004742_abnormal_vestibular_system	0.64454727
95	MP0004808_abnormal_hematopoietic_stem	0.63610773
96	MP0004043_abnormal_pH_regulation	0.62906560
97	MP0001790_abnormal_immune_system	0.61406833
98	MP0005387_immune_system_phenotype	0.61406833
99	MP0004019_abnormal_vitamin_homeostasis	0.60507363
100	MP0006072_abnormal_retinal_apoptosis	0.58092124

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	7.56234177
2	Median cleft lip (HP:0000161)	4.85938262
3	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.19525159
4	Abnormal auditory evoked potentials (HP:0006958)	4.09400764
5	Tetany (HP:0001281)	3.92020109
6	Abnormal number of incisors (HP:0011064)	3.91726842
7	Short tibia (HP:0005736)	3.81111059
8	Autoimmune thrombocytopenia (HP:0001973)	3.80492685
9	Microglossia (HP:0000171)	3.77929816
10	Oligodactyly (hands) (HP:0001180)	3.74211196
11	Congenital sensorineural hearing impairment (HP:0008527)	3.70358364
12	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.70357702
13	Abnormality of the nasal septum (HP:0000419)	3.61782307
14	Facial cleft (HP:0002006)	3.51304805
15	Abnormality of macrophages (HP:0004311)	3.45928289
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.37331673
17	Tetraparesis (HP:0002273)	3.36353454
18	Male infertility (HP:0003251)	3.22395654
19	Loss of speech (HP:0002371)	3.13019758
20	Amelogenesis imperfecta (HP:0000705)	3.12199744
21	Atonic seizures (HP:0010819)	3.02172430
22	Hyperphosphatemia (HP:0002905)	2.98220092
23	Abnormality of abdominal situs (HP:0011620)	2.93019357
24	Abdominal situs inversus (HP:0003363)	2.93019357
25	Metaphyseal dysplasia (HP:0100255)	2.88918169
26	Eczematoid dermatitis (HP:0000976)	2.78684644
27	Impulsivity (HP:0100710)	2.77592612
28	Autoimmune hemolytic anemia (HP:0001890)	2.75735240
29	Short chin (HP:0000331)	2.68101457
30	Submucous cleft hard palate (HP:0000176)	2.63616965
31	Pancreatic fibrosis (HP:0100732)	2.62727941
32	Generalized aminoaciduria (HP:0002909)	2.61197856
33	Gastrointestinal infarctions (HP:0005244)	2.59064696
34	Abnormal pancreas size (HP:0012094)	2.56768440
35	Recurrent bacterial skin infections (HP:0005406)	2.55744138
36	Recurrent gram-negative bacterial infections (HP:0005420)	2.52526686
37	Abnormality of dental color (HP:0011073)	2.51159953
38	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.51128096
39	Adrenal hypoplasia (HP:0000835)	2.51089481
40	Prostate neoplasm (HP:0100787)	2.50439942
41	Neurofibrillary tangles (HP:0002185)	2.49383901
42	Anhidrosis (HP:0000970)	2.48384829
43	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.46810610
44	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.46810610
45	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.45810544
46	Recurrent abscess formation (HP:0002722)	2.45264437
47	Abnormality of the incisor (HP:0000676)	2.33715892
48	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.33001568
49	Oligodactyly (HP:0012165)	2.31687543
50	Ectopic kidney (HP:0000086)	2.26950986
51	Type I diabetes mellitus (HP:0100651)	2.24554860
52	Maternal diabetes (HP:0009800)	2.24019260
53	Stomatitis (HP:0010280)	2.23119116
54	Abnormality of lateral ventricle (HP:0030047)	2.17675868
55	Abnormal ciliary motility (HP:0012262)	2.17310192
56	Absent/shortened dynein arms (HP:0200106)	2.17096916
57	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.17096916
58	Bony spicule pigmentary retinopathy (HP:0007737)	2.15374851
59	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.12894823
60	Glossoptosis (HP:0000162)	2.12395089
61	Abnormality of the corticospinal tract (HP:0002492)	2.10020594
62	Microretrognathia (HP:0000308)	2.05284385
63	Abnormality of chromosome stability (HP:0003220)	2.04138140
64	Myokymia (HP:0002411)	2.03419641
65	Spontaneous hematomas (HP:0007420)	2.02766242
66	Constricted visual fields (HP:0001133)	1.99810649
67	Optic neuritis (HP:0100653)	1.97438637
68	Retrobulbar optic neuritis (HP:0100654)	1.97438637
69	Partial agenesis of the corpus callosum (HP:0001338)	1.97431049
70	Short middle phalanx of the 5th finger (HP:0004220)	1.96403855
71	Peritonitis (HP:0002586)	1.92858924
72	Myositis (HP:0100614)	1.92631436
73	Pendular nystagmus (HP:0012043)	1.92485524
74	Malnutrition (HP:0004395)	1.90612942
75	Lymphopenia (HP:0001888)	1.88903042
76	Spinal muscular atrophy (HP:0007269)	1.88376904
77	Abnormality of the frontal sinuses (HP:0002687)	1.86746341
78	Dry hair (HP:0011359)	1.85499678
79	Optic nerve hypoplasia (HP:0000609)	1.81630815
80	Degeneration of anterior horn cells (HP:0002398)	1.81209912
81	Abnormality of the anterior horn cell (HP:0006802)	1.81209912
82	Attenuation of retinal blood vessels (HP:0007843)	1.79624919
83	Orchitis (HP:0100796)	1.78836707
84	Thrombocytosis (HP:0001894)	1.78796927
85	Reticulocytopenia (HP:0001896)	1.77311221
86	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77044272
87	Hypoplasia of the iris (HP:0007676)	1.77036550
88	Diaphragmatic weakness (HP:0009113)	1.75998121
89	Abnormal rod and cone electroretinograms (HP:0008323)	1.75266731
90	Abnormal respiratory motile cilium physiology (HP:0012261)	1.74830658
91	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.72758207
92	Spontaneous abortion (HP:0005268)	1.72587063
93	Acute lymphatic leukemia (HP:0006721)	1.72294906
94	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.70047183
95	Muscle fibrillation (HP:0010546)	1.69995462
96	Osteomalacia (HP:0002749)	1.69945418
97	Abnormal vertebral ossification (HP:0100569)	1.68729464
98	Chronic bronchitis (HP:0004469)	1.67871949
99	Bifid uvula (HP:0000193)	1.67659719
100	Fair hair (HP:0002286)	1.66213816

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	5.80368775
2	CDK12	4.46368432
3	CDK19	4.43483761
4	TAOK3	3.36855814
5	TNIK	3.18001352
6	MAP2K3	2.80872077
7	AURKA	2.65680795
8	PLK4	2.55015180
9	TEC	2.24294182
10	LATS2	2.15166164
11	MAP3K3	2.05331615
12	ICK	1.76269411
13	TESK2	1.76091237
14	ACVR1B	1.75076384
15	NLK	1.65706793
16	IRAK4	1.55837579
17	JAK3	1.50373947
18	VRK1	1.50045192
19	STK39	1.46881023
20	TLK1	1.46293654
21	GRK7	1.45739988
22	TXK	1.45416028
23	TNK2	1.41062821
24	MARK2	1.36129242
25	RIPK4	1.35503752
26	MAP4K1	1.31067120
27	WNK1	1.30854589
28	SRPK1	1.24906072
29	ZAK	1.15873484
30	SGK2	1.09797412
31	CDC7	1.01682910
32	STK10	0.95366924
33	CHEK2	0.94929173
34	CSK	0.94064910
35	PIM1	0.93976985
36	OXSR1	0.89166207
37	BTK	0.87853667
38	AURKB	0.85864954
39	BMPR1B	0.85259307
40	PKN1	0.82384057
41	BLK	0.81809400
42	MELK	0.81069551
43	TGFBR2	0.80307174
44	PBK	0.79022515
45	FES	0.78175366
46	IKBKE	0.76151758
47	ITK	0.76050483
48	MOS	0.75763206
49	CAMK4	0.74830770
50	PIK3CG	0.74162310
51	TBK1	0.73451382
52	SGK3	0.71307259
53	HCK	0.70815281
54	RAF1	0.69685737
55	FRK	0.68017334
56	STK24	0.67138975
57	LATS1	0.66638482
58	EPHA4	0.66244084
59	MAPKAPK2	0.63213534
60	PDK1	0.62408449
61	CHEK1	0.61439511
62	PLK1	0.60277364
63	LYN	0.60000866
64	NUAK1	0.58972325
65	PIM2	0.55600659
66	FGR	0.55349587
67	GRK5	0.54326762
68	PRKD1	0.53652039
69	MARK3	0.52612570
70	JAK2	0.52186327
71	STK4	0.51168235
72	MAP3K5	0.48674247
73	IRAK1	0.48566015
74	CSF1R	0.48423603
75	TTK	0.47468739
76	PAK1	0.46262476
77	LCK	0.46008074
78	ZAP70	0.45955179
79	SGK494	0.45897031
80	SGK223	0.45897031
81	PIK3CA	0.45711999
82	SYK	0.45486742
83	LRRK2	0.44366916
84	PDPK1	0.42754177
85	GRK6	0.41937784
86	TRIM28	0.40846472
87	PRKACB	0.40060488
88	PRKD2	0.38979482
89	TYK2	0.38129654
90	RPS6KA1	0.38056239
91	BRAF	0.33548413
92	PLK2	0.32456318
93	CAMK1	0.31455797
94	PRKACA	0.31386826
95	PRKG2	0.30854017
96	EPHB1	0.30270018
97	PTK2B	0.30266617
98	CDK7	0.29999619
99	MAPK12	0.29313761
100	NEK6	0.28569978

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	6.00621717
2	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.29173940
3	Ribosome_Homo sapiens_hsa03010	2.37229945
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.97308846
5	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.90146661
6	Homologous recombination_Homo sapiens_hsa03440	1.85870436
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.75392179
8	Bile secretion_Homo sapiens_hsa04976	1.71228001
9	Basal transcription factors_Homo sapiens_hsa03022	1.58457496
10	Sulfur metabolism_Homo sapiens_hsa00920	1.54262867
11	mRNA surveillance pathway_Homo sapiens_hsa03015	1.50939327
12	Leishmaniasis_Homo sapiens_hsa05140	1.45726995
13	Mismatch repair_Homo sapiens_hsa03430	1.40101428
14	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.39509556
15	Herpes simplex infection_Homo sapiens_hsa05168	1.29892232
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.28668939
17	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.28656925
18	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.20812578
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.20514568
20	Legionellosis_Homo sapiens_hsa05134	1.19820491
21	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.18627121
22	Retinol metabolism_Homo sapiens_hsa00830	1.17239688
23	Phototransduction_Homo sapiens_hsa04744	1.16490917
24	Regulation of autophagy_Homo sapiens_hsa04140	1.15262785
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.13842141
26	Osteoclast differentiation_Homo sapiens_hsa04380	1.12371009
27	Olfactory transduction_Homo sapiens_hsa04740	1.10190854
28	Allograft rejection_Homo sapiens_hsa05330	1.07466384
29	Oocyte meiosis_Homo sapiens_hsa04114	1.07159759
30	Chemokine signaling pathway_Homo sapiens_hsa04062	1.03946631
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.01719654
32	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.00286976
33	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.99977511
34	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99552941
35	RNA transport_Homo sapiens_hsa03013	0.99059278
36	Taste transduction_Homo sapiens_hsa04742	0.93794070
37	Renin-angiotensin system_Homo sapiens_hsa04614	0.93597396
38	Measles_Homo sapiens_hsa05162	0.93190293
39	Tuberculosis_Homo sapiens_hsa05152	0.91961707
40	Toxoplasmosis_Homo sapiens_hsa05145	0.91153506
41	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.87995476
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86952551
43	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.86910171
44	Alcoholism_Homo sapiens_hsa05034	0.85261198
45	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.85088581
46	African trypanosomiasis_Homo sapiens_hsa05143	0.84533115
47	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83914775
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.82044821
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.79481529
50	Influenza A_Homo sapiens_hsa05164	0.77448608
51	Malaria_Homo sapiens_hsa05144	0.75660717
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.75501829
53	Apoptosis_Homo sapiens_hsa04210	0.74464280
54	Primary immunodeficiency_Homo sapiens_hsa05340	0.73130404
55	Non-homologous end-joining_Homo sapiens_hsa03450	0.72194464
56	Cholinergic synapse_Homo sapiens_hsa04725	0.72074102
57	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.71855419
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.70781978
59	Phagosome_Homo sapiens_hsa04145	0.69693873
60	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.69676315
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68981832
62	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.68708948
63	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.68558641
64	Colorectal cancer_Homo sapiens_hsa05210	0.67612793
65	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.67597417
66	Acute myeloid leukemia_Homo sapiens_hsa05221	0.66596465
67	Serotonergic synapse_Homo sapiens_hsa04726	0.66519828
68	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.64336360
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63408219
70	Viral carcinogenesis_Homo sapiens_hsa05203	0.63402636
71	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.63086255
72	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.61020128
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.59375054
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58689517
75	Type I diabetes mellitus_Homo sapiens_hsa04940	0.58674706
76	Morphine addiction_Homo sapiens_hsa05032	0.57885019
77	p53 signaling pathway_Homo sapiens_hsa04115	0.57237922
78	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.57134707
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55099013
80	Insulin secretion_Homo sapiens_hsa04911	0.53964181
81	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.51862805
82	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.51606778
83	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.49751450
84	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.49010156
85	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.47242089
86	RNA polymerase_Homo sapiens_hsa03020	0.46513439
87	Platelet activation_Homo sapiens_hsa04611	0.45335851
88	Spliceosome_Homo sapiens_hsa03040	0.44762238
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.44705364
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42912820
91	GABAergic synapse_Homo sapiens_hsa04727	0.41554328
92	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.41402569
93	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41083786
94	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.40054117
95	Cocaine addiction_Homo sapiens_hsa05030	0.39898208
96	Asthma_Homo sapiens_hsa05310	0.39052340
97	Type II diabetes mellitus_Homo sapiens_hsa04930	0.38882363
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.38730242
99	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38308779
100	Gap junction_Homo sapiens_hsa04540	0.38275921

TRIM51BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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