TRIM52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.25776996
2microtubule depolymerization (GO:0007019)6.87349551
3cilium or flagellum-dependent cell motility (GO:0001539)6.40004056
4G-protein coupled receptor internalization (GO:0002031)6.16608002
5nuclear pore organization (GO:0006999)5.69190476
6nuclear pore complex assembly (GO:0051292)5.63236203
7DNA methylation involved in gamete generation (GO:0043046)5.59370192
8synaptonemal complex assembly (GO:0007130)5.29646923
9synaptonemal complex organization (GO:0070193)4.99500806
10axonemal dynein complex assembly (GO:0070286)4.98098925
11chromosome organization involved in meiosis (GO:0070192)4.94855502
12synapsis (GO:0007129)4.89860220
13meiotic chromosome segregation (GO:0045132)4.87815391
14male meiosis (GO:0007140)4.84392739
15pore complex assembly (GO:0046931)4.66061745
16behavioral response to cocaine (GO:0048148)4.62361104
17superoxide anion generation (GO:0042554)4.55816402
18male meiosis I (GO:0007141)4.50376328
19regulation of helicase activity (GO:0051095)4.47491444
20regulation of meiosis I (GO:0060631)4.39471083
21motile cilium assembly (GO:0044458)4.38719744
22reciprocal DNA recombination (GO:0035825)4.29262929
23reciprocal meiotic recombination (GO:0007131)4.29262929
24response to pheromone (GO:0019236)4.05706215
25positive regulation of cellular amide metabolic process (GO:0034250)4.00740391
26epithelial cilium movement (GO:0003351)3.97657223
27behavioral response to nicotine (GO:0035095)3.79479713
28fat-soluble vitamin catabolic process (GO:0042363)3.79439310
29vitamin catabolic process (GO:0009111)3.79439310
30replicative senescence (GO:0090399)3.76528363
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.74437021
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.74013806
33activated T cell proliferation (GO:0050798)3.71642022
34regulation of memory T cell differentiation (GO:0043380)3.71301517
35meiotic cell cycle process (GO:1903046)3.67550084
36meiotic nuclear division (GO:0007126)3.66933270
37negative regulation of DNA-dependent DNA replication (GO:2000104)3.63583417
38meiosis I (GO:0007127)3.63503688
39regulation of B cell receptor signaling pathway (GO:0050855)3.62417990
40protein K6-linked ubiquitination (GO:0085020)3.61686855
41acrosome reaction (GO:0007340)3.61681794
42interkinetic nuclear migration (GO:0022027)3.59930991
43cellular response to ATP (GO:0071318)3.54053371
44positive regulation of gamma-delta T cell activation (GO:0046645)3.53113970
45regulation of nuclear cell cycle DNA replication (GO:0033262)3.46790947
46multicellular organism reproduction (GO:0032504)3.44420658
47cilium movement (GO:0003341)3.42104834
48fucose catabolic process (GO:0019317)3.40170361
49L-fucose metabolic process (GO:0042354)3.40170361
50L-fucose catabolic process (GO:0042355)3.40170361
51negative regulation of meiosis (GO:0045835)3.36658102
52positive regulation of granulocyte differentiation (GO:0030854)3.34827631
53centriole assembly (GO:0098534)3.32858477
54oocyte maturation (GO:0001556)3.32001818
55female gonad development (GO:0008585)3.30018053
56purinergic nucleotide receptor signaling pathway (GO:0035590)3.28577482
57histone H3-K36 demethylation (GO:0070544)3.25090551
58regulation of gamma-delta T cell differentiation (GO:0045586)3.23352547
59sperm-egg recognition (GO:0035036)3.21401525
60detection of light stimulus involved in sensory perception (GO:0050962)3.20014596
61detection of light stimulus involved in visual perception (GO:0050908)3.20014596
62sister chromatid cohesion (GO:0007062)3.18600406
63positive regulation of CREB transcription factor activity (GO:0032793)3.15904562
64negative regulation of translation, ncRNA-mediated (GO:0040033)3.12602904
65regulation of translation, ncRNA-mediated (GO:0045974)3.12602904
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.12602904
67spermatid development (GO:0007286)3.12185393
68negative regulation of sodium ion transport (GO:0010766)3.10195460
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10122375
70negative regulation of cell killing (GO:0031342)3.10122375
71mismatch repair (GO:0006298)3.09627463
72monoubiquitinated protein deubiquitination (GO:0035520)3.07820710
73cellular response to gamma radiation (GO:0071480)3.06874735
74resolution of meiotic recombination intermediates (GO:0000712)3.05563471
75replication fork processing (GO:0031297)3.04660947
76regulation of gamma-delta T cell activation (GO:0046643)3.02230598
77cellular response to interferon-beta (GO:0035458)3.01714089
78startle response (GO:0001964)3.01612203
79rRNA catabolic process (GO:0016075)3.00523846
80DNA synthesis involved in DNA repair (GO:0000731)3.00160151
81cellular response to exogenous dsRNA (GO:0071360)2.99152794
82sperm motility (GO:0030317)2.98167200
83interferon-gamma production (GO:0032609)2.97826211
84omega-hydroxylase P450 pathway (GO:0097267)2.96322259
85DNA catabolic process, exonucleolytic (GO:0000738)2.95465917
86response to histamine (GO:0034776)2.94688932
87regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.93333538
88regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.93333538
89positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.93000780
90regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.93000780
91cell-cell recognition (GO:0009988)2.92493562
92regulation of mitotic spindle checkpoint (GO:1903504)2.91869239
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91869239
94DNA alkylation (GO:0006305)2.90485749
95DNA methylation (GO:0006306)2.90485749
96fusion of sperm to egg plasma membrane (GO:0007342)2.89374494
97mitotic sister chromatid cohesion (GO:0007064)2.88404264
98histone H3-K4 trimethylation (GO:0080182)2.86936864
99snRNA transcription (GO:0009301)2.84992795
100negative regulation of cAMP-mediated signaling (GO:0043951)2.82590281
101protein import into peroxisome matrix (GO:0016558)2.81525141
102regulation of male gonad development (GO:2000018)2.80968653
103neural tube formation (GO:0001841)2.80820432
104positive regulation of interleukin-1 beta secretion (GO:0050718)2.80150709
105binding of sperm to zona pellucida (GO:0007339)2.79212252
106microtubule polymerization or depolymerization (GO:0031109)2.78521557
107histone H3-K9 methylation (GO:0051567)2.77869701
108positive regulation of male gonad development (GO:2000020)2.77082559
109multicellular organismal movement (GO:0050879)2.75465166
110musculoskeletal movement (GO:0050881)2.75465166
111histone H3-K9 modification (GO:0061647)2.75129026
112DNA double-strand break processing (GO:0000729)2.74767805
113response to X-ray (GO:0010165)2.74229320
114axoneme assembly (GO:0035082)2.74188639
115detection of bacterium (GO:0016045)2.70614556
116establishment of protein localization to Golgi (GO:0072600)2.70171830
117protein K11-linked deubiquitination (GO:0035871)2.70039033
118positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.69715146
119prepulse inhibition (GO:0060134)2.69653275
120indolalkylamine metabolic process (GO:0006586)2.68615341
121regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.68407562
122negative T cell selection (GO:0043383)2.68313950
123detection of other organism (GO:0098543)2.67963878
124regulation of double-strand break repair via homologous recombination (GO:0010569)2.67707271
125response to interleukin-15 (GO:0070672)2.67033801
126cAMP catabolic process (GO:0006198)2.66966670
127regulation of centriole replication (GO:0046599)2.66805790
128preassembly of GPI anchor in ER membrane (GO:0016254)2.66481388
129cell wall macromolecule catabolic process (GO:0016998)2.66398135
130cell wall macromolecule metabolic process (GO:0044036)2.66398135
131cellular response to interleukin-15 (GO:0071350)2.65183042
132DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.65130363
133positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.64944160
134positive T cell selection (GO:0043368)2.64754485
135B cell receptor signaling pathway (GO:0050853)2.64250818
136oogenesis (GO:0048477)2.64222121
137reflex (GO:0060004)2.62762679
138negative thymic T cell selection (GO:0045060)2.61284633
139DNA damage response, signal transduction resulting in transcription (GO:0042772)2.60214246
140detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59459986
141RNA destabilization (GO:0050779)2.58175837
142negative regulation of oligodendrocyte differentiation (GO:0048715)2.57967430
143DNA methylation or demethylation (GO:0044728)2.57691837
144protein localization to microtubule (GO:0035372)2.57376770
145telomere maintenance via recombination (GO:0000722)2.56795376
146meiotic cell cycle (GO:0051321)2.56284153
147kinetochore organization (GO:0051383)2.55535357
148kinetochore assembly (GO:0051382)2.54749599
149negative regulation of protein oligomerization (GO:0032460)2.50078863
150regulation of interleukin-6 biosynthetic process (GO:0045408)2.49071413
151regulation of regulatory T cell differentiation (GO:0045589)2.48897638
152cardiovascular system development (GO:0072358)2.47434710
153antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.46495039
154tolerance induction (GO:0002507)2.46269697
155mast cell degranulation (GO:0043303)2.43207343
156mast cell activation involved in immune response (GO:0002279)2.43207343
157transepithelial transport (GO:0070633)2.41702613
158regulation of MHC class I biosynthetic process (GO:0045343)2.38865431
159DNA deamination (GO:0045006)2.36724727
160indole-containing compound catabolic process (GO:0042436)2.36627747
161indolalkylamine catabolic process (GO:0046218)2.36627747
162tryptophan catabolic process (GO:0006569)2.36627747
163cyclic nucleotide catabolic process (GO:0009214)2.32718354
164negative regulation of T cell mediated immunity (GO:0002710)2.32476185
165negative regulation of lymphocyte mediated immunity (GO:0002707)2.32271383
166positive regulation of defense response to virus by host (GO:0002230)2.31956105
167negative regulation of Rho protein signal transduction (GO:0035024)2.31507890
168mitotic cell cycle arrest (GO:0071850)2.31279226
169histone mRNA catabolic process (GO:0071044)2.30613210
170protein localization to Golgi apparatus (GO:0034067)2.29785026
171S-adenosylmethionine metabolic process (GO:0046500)2.29544866
172regulation of cilium movement (GO:0003352)2.29308872
173peptidyl-lysine methylation (GO:0018022)2.28567387
174regulation of granulocyte differentiation (GO:0030852)2.28516943
175cellular response to ethanol (GO:0071361)2.28375673
176cardiolipin metabolic process (GO:0032048)2.26939661
177positive regulation of mRNA catabolic process (GO:0061014)2.25066438
178mast cell activation (GO:0045576)2.24368168
179positive regulation of developmental pigmentation (GO:0048087)2.23921050
180regulation of interleukin-12 biosynthetic process (GO:0045075)2.23214704
181protein K48-linked deubiquitination (GO:0071108)2.22966217
182positive regulation of T cell mediated cytotoxicity (GO:0001916)2.20439959
183negative regulation of neurotransmitter transport (GO:0051589)2.20121922
184antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.20073497
185tryptophan metabolic process (GO:0006568)2.19936151
186cornea development in camera-type eye (GO:0061303)2.19397924
187phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.18888587
188NAD biosynthetic process (GO:0009435)2.18804188
189negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.18412793
190negative regulation of T-helper cell differentiation (GO:0045623)2.17913692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.95742776
2PCGF2_27294783_Chip-Seq_ESCs_Mouse3.90558171
3FLI1_27457419_Chip-Seq_LIVER_Mouse3.79895642
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.43631779
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.37480017
6ZNF274_21170338_ChIP-Seq_K562_Hela3.18722172
7NFE2_27457419_Chip-Seq_LIVER_Mouse3.10277126
8SUZ12_27294783_Chip-Seq_NPCs_Mouse3.07419690
9PCGF2_27294783_Chip-Seq_NPCs_Mouse3.00572772
10EZH2_22144423_ChIP-Seq_EOC_Human2.87844476
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.81290734
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.78624350
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70499323
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.57078784
15EZH2_27294783_Chip-Seq_NPCs_Mouse2.56585403
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.44653538
17GBX2_23144817_ChIP-Seq_PC3_Human2.44052513
18* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38307305
19VDR_22108803_ChIP-Seq_LS180_Human2.31209939
20EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.30921197
21STAT3_18555785_Chip-Seq_ESCs_Mouse2.27822263
22IRF1_19129219_ChIP-ChIP_H3396_Human2.25899959
23E2F1_18555785_Chip-Seq_ESCs_Mouse2.24836626
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.20839380
25SUZ12_18555785_Chip-Seq_ESCs_Mouse2.20061228
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17723614
27NANOG_18555785_Chip-Seq_ESCs_Mouse2.14161048
28TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.13885188
29P53_22387025_ChIP-Seq_ESCs_Mouse2.05540917
30NMYC_18555785_Chip-Seq_ESCs_Mouse2.03620867
31RUNX1_27457419_Chip-Seq_LIVER_Mouse2.00525449
32OCT4_18555785_Chip-Seq_ESCs_Mouse1.98389485
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95821025
34EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.94672919
35CMYC_18555785_Chip-Seq_ESCs_Mouse1.94106602
36P300_18555785_Chip-Seq_ESCs_Mouse1.92198976
37GATA1_22025678_ChIP-Seq_K562_Human1.89004357
38TAF15_26573619_Chip-Seq_HEK293_Human1.88910704
39CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.87849615
40RUNX_20019798_ChIP-Seq_JUKART_Human1.87610704
41OCT4_21477851_ChIP-Seq_ESCs_Mouse1.86653299
42CRX_20693478_ChIP-Seq_RETINA_Mouse1.79832187
43ESRRB_18555785_Chip-Seq_ESCs_Mouse1.78690170
44PU1_27457419_Chip-Seq_LIVER_Mouse1.78595311
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.78158587
46SOX2_18555785_Chip-Seq_ESCs_Mouse1.77036371
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.75341757
48ZFX_18555785_Chip-Seq_ESCs_Mouse1.71973182
49* RNF2_27304074_Chip-Seq_NSC_Mouse1.71213633
50CTCF_18555785_Chip-Seq_ESCs_Mouse1.70756008
51KLF4_18555785_Chip-Seq_ESCs_Mouse1.69803908
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.68366127
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67628772
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67529931
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66912051
56SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.66681020
57SMAD1_18555785_Chip-Seq_ESCs_Mouse1.66410174
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64969845
59SCL_19346495_ChIP-Seq_HPC-7_Human1.62332418
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60891809
61GATA3_26560356_Chip-Seq_TH2_Human1.59775005
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54397777
63FUS_26573619_Chip-Seq_HEK293_Human1.53378928
64MYB_26560356_Chip-Seq_TH2_Human1.52678939
65CIITA_25753668_ChIP-Seq_RAJI_Human1.51078109
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.49305325
67TP53_22573176_ChIP-Seq_HFKS_Human1.48353273
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47866373
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47473128
70GATA3_27048872_Chip-Seq_THYMUS_Human1.45102540
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41922502
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.41747756
73IGF1R_20145208_ChIP-Seq_DFB_Human1.40765932
74AR_21572438_ChIP-Seq_LNCaP_Human1.38335109
75* CBX2_27304074_Chip-Seq_ESCs_Mouse1.37824078
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36519827
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36086523
78STAT1_17558387_ChIP-Seq_HELA_Human1.35457392
79ERA_21632823_ChIP-Seq_H3396_Human1.33535309
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32806480
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32806480
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32250289
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31364890
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28853485
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27937358
86DROSHA_22980978_ChIP-Seq_HELA_Human1.27009217
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26406384
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26310257
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.25081581
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25036284
91* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24476982
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23002374
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.22942457
94CBP_20019798_ChIP-Seq_JUKART_Human1.21614221
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21614221
96* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20878092
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20778955
98MYB_26560356_Chip-Seq_TH1_Human1.18764565
99MAF_26560356_Chip-Seq_TH2_Human1.17615705
100REST_21632747_ChIP-Seq_MESCs_Mouse1.16657666
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15838115
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15611659
103NCOR_22424771_ChIP-Seq_293T_Human1.15183396
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14746663
105ETV1_20927104_ChIP-Seq_GIST48_Human1.14704905
106TCF4_23295773_ChIP-Seq_U87_Human1.13594310
107OCT4_20526341_ChIP-Seq_ESCs_Human1.13575198
108SMAD4_21799915_ChIP-Seq_A2780_Human1.13395412
109* VDR_23849224_ChIP-Seq_CD4+_Human1.13313218
110NANOG_20526341_ChIP-Seq_ESCs_Human1.11376788
111P300_19829295_ChIP-Seq_ESCs_Human1.09840859
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09428316
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09264237
114HOXB7_26014856_ChIP-Seq_BT474_Human1.09236928
115STAT3_23295773_ChIP-Seq_U87_Human1.09100027
116SMRT_27268052_Chip-Seq_Bcells_Human1.07562323
117HTT_18923047_ChIP-ChIP_STHdh_Human1.07222722
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06620120
119RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05840467
120MAF_26560356_Chip-Seq_TH1_Human1.04968112
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04205256
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02823859
123GATA1_26923725_Chip-Seq_HPCs_Mouse1.02111250
124* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.01940860
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01807973
126TAF2_19829295_ChIP-Seq_ESCs_Human1.01733175
127ER_23166858_ChIP-Seq_MCF-7_Human1.01574491
128FOXA1_25329375_ChIP-Seq_VCAP_Human1.01185694
129FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01185694
130KDM2B_26808549_Chip-Seq_REH_Human1.01148766
131RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00525247
132VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00412997
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00184915
134TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00129141
135GATA3_26560356_Chip-Seq_TH1_Human0.99783328
136PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97965981
137MYC_19829295_ChIP-Seq_ESCs_Human0.97823116
138* EWS_26573619_Chip-Seq_HEK293_Human0.97674242
139HNFA_21074721_ChIP-Seq_CACO-2_Human0.97273805
140P53_21459846_ChIP-Seq_SAOS-2_Human0.97052442
141SMAD_19615063_ChIP-ChIP_OVARY_Human0.96207079
142FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95482636
143E2F1_20622854_ChIP-Seq_HELA_Human0.94942530
144RBPJ_21746931_ChIP-Seq_IB4_Human0.94821425
145BCL6_27268052_Chip-Seq_Bcells_Human0.93655253
146NFYB_21822215_ChIP-Seq_K562_Human0.93528931
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93247593
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92470872
149PHF8_20622853_ChIP-Seq_HELA_Human0.90518272
150RUNX2_22187159_ChIP-Seq_PCA_Human0.90239972
151CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89393387
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.89303184
153LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89166884
154MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89140589
155EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89129291
156PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89075973
157TCF4_22108803_ChIP-Seq_LS180_Human0.89044375
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.88993061
159TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.88322704
160EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87491818
161CDX2_22108803_ChIP-Seq_LS180_Human0.86504165
162UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85900665
163TBL1_22424771_ChIP-Seq_293T_Human0.85855963
164NFYA_21822215_ChIP-Seq_K562_Human0.85189069
165VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84796459
166CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84069624
167BCAT_22108803_ChIP-Seq_LS180_Human0.84051295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.48538992
2MP0008877_abnormal_DNA_methylation4.72766860
3MP0003787_abnormal_imprinting4.29627813
4MP0003941_abnormal_skin_development3.88058509
5MP0008057_abnormal_DNA_replication3.86447310
6MP0008058_abnormal_DNA_repair3.79655888
7MP0005410_abnormal_fertilization3.60009271
8MP0005645_abnormal_hypothalamus_physiol3.50355801
9MP0005174_abnormal_tail_pigmentation3.05976562
10MP0001188_hyperpigmentation3.04210660
11MP0010094_abnormal_chromosome_stability2.90131156
12MP0004043_abnormal_pH_regulation2.71582157
13MP0000569_abnormal_digit_pigmentation2.61758801
14MP0002210_abnormal_sex_determination2.38114624
15MP0003195_calcinosis2.37450584
16MP0003111_abnormal_nucleus_morphology2.32713745
17MP0001929_abnormal_gametogenesis2.27396119
18MP0000566_synostosis2.23585905
19MP0005423_abnormal_somatic_nervous2.07822719
20MP0003698_abnormal_male_reproductive2.01863911
21MP0001968_abnormal_touch/_nociception2.01472708
22MP0003646_muscle_fatigue2.00281375
23MP0002638_abnormal_pupillary_reflex1.97173192
24MP0004130_abnormal_muscle_cell1.90853367
25MP0009697_abnormal_copulation1.89062082
26MP0001800_abnormal_humoral_immune1.87990624
27MP0003868_abnormal_feces_composition1.86536467
28MP0008995_early_reproductive_senescence1.84018784
29MP0004381_abnormal_hair_follicle1.78701922
30MP0008007_abnormal_cellular_replicative1.76018547
31MP0001145_abnormal_male_reproductive1.72618415
32MP0003786_premature_aging1.72314819
33MP0002009_preneoplasia1.71949697
34MP0003763_abnormal_thymus_physiology1.71517692
35MP0002928_abnormal_bile_duct1.69336752
36MP0000015_abnormal_ear_pigmentation1.68768970
37MP0002396_abnormal_hematopoietic_system1.68496838
38MP0003136_yellow_coat_color1.65959278
39MP0010307_abnormal_tumor_latency1.63766041
40MP0000653_abnormal_sex_gland1.62305172
41MP0000383_abnormal_hair_follicle1.59358774
42MP0002163_abnormal_gland_morphology1.52642266
43MP0005075_abnormal_melanosome_morpholog1.50482977
44MP0005171_absent_coat_pigmentation1.47873714
45MP0001119_abnormal_female_reproductive1.46737518
46MP0003121_genomic_imprinting1.45508461
47MP0005623_abnormal_meninges_morphology1.45171581
48MP0002138_abnormal_hepatobiliary_system1.43429096
49MP0001502_abnormal_circadian_rhythm1.41969209
50MP0005248_abnormal_Harderian_gland1.40535956
51MP0001501_abnormal_sleep_pattern1.38138857
52MP0002837_dystrophic_cardiac_calcinosis1.37372896
53MP0005646_abnormal_pituitary_gland1.34056013
54MP0008875_abnormal_xenobiotic_pharmacok1.33383575
55MP0004142_abnormal_muscle_tone1.32928508
56MP0002723_abnormal_immune_serum1.32657978
57MP0000685_abnormal_immune_system1.31877367
58MP0002160_abnormal_reproductive_system1.28871240
59MP0000490_abnormal_crypts_of1.28483602
60MP0003252_abnormal_bile_duct1.27316753
61MP0003693_abnormal_embryo_hatching1.26911929
62MP0002102_abnormal_ear_morphology1.26400594
63MP0003724_increased_susceptibility_to1.26075543
64MP0003077_abnormal_cell_cycle1.24819331
65MP0005253_abnormal_eye_physiology1.23281961
66MP0002735_abnormal_chemical_nociception1.22923881
67MP0008872_abnormal_physiological_respon1.22778463
68MP0005647_abnormal_sex_gland1.22227729
69MP0001873_stomach_inflammation1.21975965
70MP0008961_abnormal_basal_metabolism1.20409465
71MP0009745_abnormal_behavioral_response1.19262382
72MP0002420_abnormal_adaptive_immunity1.17809739
73MP0001819_abnormal_immune_cell1.15486180
74MP0002127_abnormal_cardiovascular_syste1.15131175
75MP0002277_abnormal_respiratory_mucosa1.14018707
76MP0003172_abnormal_lysosome_physiology1.13612633
77MP0002161_abnormal_fertility/fecundity1.12771392
78MP0002272_abnormal_nervous_system1.12564112
79MP0002398_abnormal_bone_marrow1.12089260
80MP0006082_CNS_inflammation1.12049446
81MP0002452_abnormal_antigen_presenting1.10962091
82MP0002132_abnormal_respiratory_system1.10376547
83MP0005167_abnormal_blood-brain_barrier1.09700585
84MP0005083_abnormal_biliary_tract1.09572651
85MP0005389_reproductive_system_phenotype1.07420075
86MP0000427_abnormal_hair_cycle1.07356431
87MP0000689_abnormal_spleen_morphology1.07308997
88MP0000703_abnormal_thymus_morphology1.07022180
89MP0005220_abnormal_exocrine_pancreas1.06199483
90MP0009046_muscle_twitch1.05508405
91MP0003123_paternal_imprinting1.04489810
92MP0001346_abnormal_lacrimal_gland1.04133052
93MP0005367_renal/urinary_system_phenotyp1.03349331
94MP0000516_abnormal_urinary_system1.03349331
95MP0000716_abnormal_immune_system1.02997449
96MP0000647_abnormal_sebaceous_gland1.01709331
97MP0004782_abnormal_surfactant_physiolog1.01499168
98MP0002148_abnormal_hypersensitivity_rea0.99950065
99MP0005000_abnormal_immune_tolerance0.98616324
100MP0005257_abnormal_intraocular_pressure0.97279032
101MP0002876_abnormal_thyroid_physiology0.96909014
102MP0004019_abnormal_vitamin_homeostasis0.96156318
103MP0001765_abnormal_ion_homeostasis0.94417387
104MP0006072_abnormal_retinal_apoptosis0.93912395
105MP0004808_abnormal_hematopoietic_stem0.93165961
106MP0004885_abnormal_endolymph0.92977696
107MP0004147_increased_porphyrin_level0.92904628
108MP0005379_endocrine/exocrine_gland_phen0.92446458
109MP0009672_abnormal_birth_weight0.91962446
110MP0002736_abnormal_nociception_after0.91398998
111MP0002064_seizures0.90341486
112MP0001835_abnormal_antigen_presentation0.90201536
113MP0005551_abnormal_eye_electrophysiolog0.90078957
114MP0002693_abnormal_pancreas_physiology0.89523789
115MP0002722_abnormal_immune_system0.88106703
116MP0004924_abnormal_behavior0.87234295
117MP0005386_behavior/neurological_phenoty0.87234295
118MP0003635_abnormal_synaptic_transmissio0.87144757
119MP0002405_respiratory_system_inflammati0.87141620
120MP0001727_abnormal_embryo_implantation0.86407051
121MP0003011_delayed_dark_adaptation0.86179186
122MP0002063_abnormal_learning/memory/cond0.85189170
123MP0008775_abnormal_heart_ventricle0.84047237
124MP0002166_altered_tumor_susceptibility0.83207844
125MP0004133_heterotaxia0.82557910
126MP0003436_decreased_susceptibility_to0.82339233
127MP0008932_abnormal_embryonic_tissue0.82108087
128MP0009764_decreased_sensitivity_to0.81498714
129MP0003878_abnormal_ear_physiology0.79569572
130MP0005377_hearing/vestibular/ear_phenot0.79569572
131MP0000631_abnormal_neuroendocrine_gland0.79336473
132MP0001545_abnormal_hematopoietic_system0.79030744
133MP0005397_hematopoietic_system_phenotyp0.79030744
134MP0001970_abnormal_pain_threshold0.78674315
135MP0005448_abnormal_energy_balance0.78660204
136MP0000579_abnormal_nail_morphology0.78498559
137MP0003936_abnormal_reproductive_system0.78455619
138MP0002095_abnormal_skin_pigmentation0.77933367
139MP0002067_abnormal_sensory_capabilities0.76987924
140MP0001853_heart_inflammation0.76879498
141MP0002572_abnormal_emotion/affect_behav0.76700668
142MP0002249_abnormal_larynx_morphology0.75713758
143MP0006276_abnormal_autonomic_nervous0.75670401
144MP0001191_abnormal_skin_condition0.75649388
145MP0009785_altered_susceptibility_to0.74693060
146MP0005310_abnormal_salivary_gland0.74497282
147MP0000613_abnormal_salivary_gland0.73639421
148MP0001986_abnormal_taste_sensitivity0.72453340
149MP0009703_decreased_birth_body0.70776966
150MP0003699_abnormal_female_reproductive0.69473840
151MP0003119_abnormal_digestive_system0.64533876
152MP0001486_abnormal_startle_reflex0.64141741
153MP0000627_abnormal_mammary_gland0.64073691
154MP0002282_abnormal_trachea_morphology0.60563536
155MP0005085_abnormal_gallbladder_physiolo0.60426871
156MP0002419_abnormal_innate_immunity0.57289133
157MP0000026_abnormal_inner_ear0.56225060
158MP0003890_abnormal_embryonic-extraembry0.56105306
159MP0006292_abnormal_olfactory_placode0.55250190
160MP0001984_abnormal_olfaction0.53610016
161MP0004197_abnormal_fetal_growth/weight/0.53023378
162MP0005025_abnormal_response_to0.52434659
163MP0004957_abnormal_blastocyst_morpholog0.51898437
164MP0004742_abnormal_vestibular_system0.51657967
165MP0000465_gastrointestinal_hemorrhage0.51285009
166MP0001790_abnormal_immune_system0.51051803
167MP0005387_immune_system_phenotype0.51051803
168MP0002139_abnormal_hepatobiliary_system0.50919203
169MP0003718_maternal_effect0.50211034
170MP0001919_abnormal_reproductive_system0.49499420
171MP0005671_abnormal_response_to0.48286636

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.78094348
2Chromsome breakage (HP:0040012)6.15330453
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.27063934
4Congenital stationary night blindness (HP:0007642)4.16376521
5Prostate neoplasm (HP:0100787)4.16274328
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.15711200
7Absent/shortened dynein arms (HP:0200106)4.15711200
8Tubulointerstitial nephritis (HP:0001970)4.10886376
9Attenuation of retinal blood vessels (HP:0007843)4.01841158
10Abnormal respiratory motile cilium physiology (HP:0012261)3.95854985
11Abnormal ciliary motility (HP:0012262)3.53294569
12Hyperventilation (HP:0002883)3.51988931
13Abnormal respiratory motile cilium morphology (HP:0005938)3.49931401
14Abnormal respiratory epithelium morphology (HP:0012253)3.49931401
15Pancreatic cysts (HP:0001737)3.49881167
16Neoplasm of the adrenal cortex (HP:0100641)3.43993444
17High anterior hairline (HP:0009890)3.34905590
18Abnormality of the preputium (HP:0100587)3.27701617
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.26197037
20Meckel diverticulum (HP:0002245)3.16526508
21Abnormality of midbrain morphology (HP:0002418)3.11484407
22Molar tooth sign on MRI (HP:0002419)3.11484407
23Genetic anticipation (HP:0003743)3.02929455
24Abnormality of the ileum (HP:0001549)3.01880848
25Azoospermia (HP:0000027)2.99981978
26Abnormality of chromosome stability (HP:0003220)2.95691431
27Nephronophthisis (HP:0000090)2.94731837
28Clumsiness (HP:0002312)2.93966672
29Protruding tongue (HP:0010808)2.84252588
30Abnormal drinking behavior (HP:0030082)2.83438226
31Polydipsia (HP:0001959)2.83438226
32Decreased circulating renin level (HP:0003351)2.81000737
33Febrile seizures (HP:0002373)2.80243905
34Abnormality of the renal medulla (HP:0100957)2.79267017
35Abnormal spermatogenesis (HP:0008669)2.75166177
36Rhinitis (HP:0012384)2.74162051
37Median cleft lip (HP:0000161)2.67337907
38Short tibia (HP:0005736)2.62748168
39Pancreatic fibrosis (HP:0100732)2.56353198
40Clubbing of toes (HP:0100760)2.56128373
41Tubulointerstitial abnormality (HP:0001969)2.55049429
42Hepatoblastoma (HP:0002884)2.53283016
43Bony spicule pigmentary retinopathy (HP:0007737)2.53228864
44Septo-optic dysplasia (HP:0100842)2.52318759
45Bone marrow hypocellularity (HP:0005528)2.49498270
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.48546818
47Birth length less than 3rd percentile (HP:0003561)2.46709747
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.46508462
49Absent speech (HP:0001344)2.45121870
50Abnormality of the carotid arteries (HP:0005344)2.43264870
51Decreased central vision (HP:0007663)2.41483555
52Progressive cerebellar ataxia (HP:0002073)2.40085015
53Medial flaring of the eyebrow (HP:0010747)2.39972377
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.39330790
55Patellar aplasia (HP:0006443)2.33172874
56Gaze-evoked nystagmus (HP:0000640)2.32112863
57Chronic mucocutaneous candidiasis (HP:0002728)2.30677994
58Recurrent cutaneous fungal infections (HP:0011370)2.30677994
59Fair hair (HP:0002286)2.30634782
60Facial cleft (HP:0002006)2.29477904
61Embryonal renal neoplasm (HP:0011794)2.29476714
62Enlarged kidneys (HP:0000105)2.28405759
63Broad-based gait (HP:0002136)2.28298818
64Curly hair (HP:0002212)2.28183944
65Panhypogammaglobulinemia (HP:0003139)2.27234523
66Chorioretinal atrophy (HP:0000533)2.26672864
67Gastrointestinal infarctions (HP:0005244)2.26380571
68Fibular hypoplasia (HP:0003038)2.25674618
69Nephroblastoma (Wilms tumor) (HP:0002667)2.24487533
70Myelomeningocele (HP:0002475)2.23180887
71Tubular atrophy (HP:0000092)2.20646919
72Duplicated collecting system (HP:0000081)2.19712414
73Widely spaced teeth (HP:0000687)2.16816491
74Ectopic kidney (HP:0000086)2.16636572
75Elevated erythrocyte sedimentation rate (HP:0003565)2.16074435
76Abnormality of male internal genitalia (HP:0000022)2.15184893
77Severe Myopia (HP:0011003)2.13531913
78Bronchiectasis (HP:0002110)2.13272888
79Aplasia/Hypoplasia of the patella (HP:0006498)2.13035430
80Male pseudohermaphroditism (HP:0000037)2.12314424
81Polyuria (HP:0000103)2.11875368
82Supernumerary spleens (HP:0009799)2.10421926
83Postaxial foot polydactyly (HP:0001830)2.08962677
84Inability to walk (HP:0002540)2.07909876
85Bell-shaped thorax (HP:0001591)2.07766222
86Stomatitis (HP:0010280)2.07532211
87Cystic liver disease (HP:0006706)2.07448183
88Recurrent pneumonia (HP:0006532)2.06945437
89Prolonged bleeding time (HP:0003010)2.06252232
90Facial diplegia (HP:0001349)2.06122706
91Type II lissencephaly (HP:0007260)2.05219654
92Abnormality of the prostate (HP:0008775)2.04848078
93Stomach cancer (HP:0012126)2.03833224
94Lip pit (HP:0100267)2.03751966
95Abnormal rod and cone electroretinograms (HP:0008323)2.02941495
96Recurrent sinusitis (HP:0011108)2.02860025
97Upper limb muscle weakness (HP:0003484)2.01694427
98Hypoplasia of the pons (HP:0012110)2.00832237
99Abolished electroretinogram (ERG) (HP:0000550)2.00637493
100Abnormality of the pons (HP:0007361)2.00087782
101Adrenal hypoplasia (HP:0000835)1.99411668
102Increased number of teeth (HP:0011069)1.98766518
103Myelodysplasia (HP:0002863)1.98365663
104Infertility (HP:0000789)1.98068023
105Rib fusion (HP:0000902)1.97717120
106Intestinal fistula (HP:0100819)1.97343510
107Ketosis (HP:0001946)1.96929334
108Recurrent fungal infections (HP:0002841)1.96667727
109Encephalitis (HP:0002383)1.96640038
110Mesomelia (HP:0003027)1.95879646
111Absent thumb (HP:0009777)1.95445216
112Abnormality of DNA repair (HP:0003254)1.93780715
113Duodenal stenosis (HP:0100867)1.93231519
114Small intestinal stenosis (HP:0012848)1.93231519
115Acute lymphatic leukemia (HP:0006721)1.92832860
116Pendular nystagmus (HP:0012043)1.92832643
117Hypoalbuminemia (HP:0003073)1.91491525
118Abnormal albumin level (HP:0012116)1.91491525
119Leukopenia (HP:0001882)1.91277742
120Myositis (HP:0100614)1.91043300
121Neonatal hypoglycemia (HP:0001998)1.90312758
122Ketoacidosis (HP:0001993)1.89960743
123Generalized hypopigmentation of hair (HP:0011358)1.88369091
124Short chin (HP:0000331)1.88362572
125Papilledema (HP:0001085)1.88025797
126Abnormality of the renal collecting system (HP:0004742)1.87617028
127Hypochromic microcytic anemia (HP:0004840)1.87093483
128Bile duct proliferation (HP:0001408)1.86580375
129Abnormal biliary tract physiology (HP:0012439)1.86580375
130Gonadotropin excess (HP:0000837)1.86502731
131Short thorax (HP:0010306)1.85866350
132Abnormality of renin-angiotensin system (HP:0000847)1.84732215
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84428445
134Poor coordination (HP:0002370)1.81471775
135Renal cortical cysts (HP:0000803)1.80210978
136Bifid tongue (HP:0010297)1.79448203
137Hypochromic anemia (HP:0001931)1.78729454
138Testicular atrophy (HP:0000029)1.77986576
139Rectal fistula (HP:0100590)1.77597344
140Rectovaginal fistula (HP:0000143)1.77597344
141Abnormality of T cell physiology (HP:0011840)1.77531743
142Gait imbalance (HP:0002141)1.77503655
143Tachypnea (HP:0002789)1.77471974
144Metabolic alkalosis (HP:0200114)1.77248116
145Chronic hepatic failure (HP:0100626)1.77138924
146Oligohydramnios (HP:0001562)1.76470966
147Distal lower limb muscle weakness (HP:0009053)1.76465356
148Astigmatism (HP:0000483)1.76370824
149Orchitis (HP:0100796)1.76273423
150Abnormality of the labia minora (HP:0012880)1.76075299
151Abnormal sex determination (HP:0012244)1.75510234
152Sex reversal (HP:0012245)1.75510234
153Absent epiphyses (HP:0010577)1.74907751
154Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74907751
155Progressive sensorineural hearing impairment (HP:0000408)1.74641635
156Abnormal urine output (HP:0012590)1.74419419
157Recurrent abscess formation (HP:0002722)1.74409430
158Abnormality of the fingertips (HP:0001211)1.74378112
159Wide intermamillary distance (HP:0006610)1.74267159
160Hyperkalemia (HP:0002153)1.74040849
161Abnormality of the renal cortex (HP:0011035)1.72871059
162Short thumb (HP:0009778)1.72830395
163Congenital primary aphakia (HP:0007707)1.72214810
164Dyskinesia (HP:0100660)1.70393556
165Abnormality of T cells (HP:0002843)1.69351215
166Absent frontal sinuses (HP:0002688)1.69021329
167Acute myeloid leukemia (HP:0004808)1.68788527
168Congenital hepatic fibrosis (HP:0002612)1.68391236
169Macroglossia (HP:0000158)1.67856527
170Progressive inability to walk (HP:0002505)1.67579197
171Epileptic encephalopathy (HP:0200134)1.67454964
172True hermaphroditism (HP:0010459)1.67310575
173Retrobulbar optic neuritis (HP:0100654)1.67063360
174Optic neuritis (HP:0100653)1.67063360
175Cleft eyelid (HP:0000625)1.66699677
176Scrotal hypoplasia (HP:0000046)1.65998871
177Alveolar cell carcinoma (HP:0006519)1.63815393
178Intellectual disability, severe (HP:0010864)1.61919139
179Atonic seizures (HP:0010819)1.60916395
180Neoplasm of the tracheobronchial system (HP:0100552)1.60703348
181Nephrogenic diabetes insipidus (HP:0009806)1.60017183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.04842032
2ZAK3.49497593
3WNK43.10199168
4ICK3.03222821
5TAOK32.86404060
6BMPR1B2.71571108
7EIF2AK22.48257053
8AKT32.27698877
9RIPK42.27198166
10SIK22.22289341
11EIF2AK12.17322651
12IRAK32.14611930
13GRK12.13415086
14TXK2.11495723
15PDK42.03474670
16PDK32.03474670
17MAP4K11.99872735
18YES11.92052463
19TTK1.87538438
20MAPK151.77891096
21TEC1.74389555
22CDK121.74018272
23INSRR1.72262879
24BRD41.70075233
25STK38L1.68971940
26CDK81.67084357
27STK31.66634370
28CAMKK21.63955968
29LATS11.61400053
30MAP2K71.60391374
31STK161.60070376
32SRPK11.57930300
33PDK21.54816735
34TLK11.51802789
35MAPK131.49251187
36BLK1.47175882
37KIT1.45257428
38TNK21.44966155
39ACVR1B1.41910199
40MKNK21.41043919
41SYK1.39543638
42NUAK11.37543401
43EPHA21.37105058
44PINK11.31490012
45MAP2K61.30631293
46CDC71.30049105
47DYRK31.27920198
48CDK71.26393381
49ATR1.25463940
50WNK11.24489324
51MAP3K41.23957358
52NTRK31.22583813
53BTK1.21682950
54CSNK1A1L1.20519355
55PIM11.19625896
56CASK1.19425203
57GRK61.18987800
58CDK31.13927048
59MAP3K71.11557493
60IKBKE1.11376477
61IKBKB1.11350269
62PLK41.09540894
63ADRBK21.07868674
64NME21.06859880
65ITK1.06801166
66MAP3K141.05735118
67CHEK21.05240292
68CAMKK11.04283670
69PLK11.03413808
70TGFBR11.02502330
71OXSR11.02443644
72NEK21.01878555
73MARK31.01421601
74PRKCQ1.00301708
75STK391.00167014
76JAK10.97286438
77BCR0.91879606
78DYRK20.90568420
79MAP3K130.90400611
80FES0.90358403
81PAK30.87729661
82IRAK40.87020605
83PBK0.86758400
84FGFR30.86203161
85MAP4K20.84472333
86MKNK10.83139800
87LCK0.82136022
88JAK30.81389251
89ADRBK10.81344819
90CDK90.79735758
91LYN0.79686401
92STK110.79450731
93FLT30.79279810
94PIK3CA0.79156035
95STK40.79067237
96EIF2AK30.78699764
97CSNK1G10.77831823
98RPS6KB20.77185807
99ERBB30.76390468
100TSSK60.76337238
101FGFR20.75529095
102TRPM70.73346484
103CHUK0.71788170
104PRKCH0.71742855
105SGK4940.71022447
106SGK2230.71022447
107HCK0.70323519
108ALK0.69408391
109ATM0.68878999
110MAP3K60.68857481
111TYK20.68384034
112SGK20.67062674
113MAPK110.67030043
114EPHA30.66459566
115CCNB10.65442121
116PRKD20.65087831
117PRKAA20.64193898
118ERBB40.63608259
119WEE10.62736388
120RPS6KA60.62511393
121ZAP700.62305991
122GRK70.62076738
123CSNK1G30.62027751
124SGK10.61713740
125MAPK120.61407072
126NLK0.60298827
127HIPK20.60064662
128AKT20.59074870
129NTRK20.57266933
130RPS6KB10.57247067
131PDK10.57169247
132CHEK10.56844718
133MARK20.56315957
134CAMK1D0.55638066
135WNK30.55365426
136JAK20.55136445
137PLK30.54983270
138MAP2K40.54727613
139PRPF4B0.54347262
140EPHB20.53948432
141CLK10.53835864
142CAMK10.53580665
143IRAK10.53135204
144CDK40.53110634
145PRKAA10.52246164
146BRSK20.51098225
147PLK20.50832383
148MAPK70.50475910
149PASK0.49996748
150BMPR20.49030483
151CSF1R0.45661256
152CSK0.45268068
153DAPK20.44965504
154MAPKAPK30.43413054
155CDK20.42284904
156PRKCE0.40675849
157TYRO30.40508674
158CDK10.40073300
159MELK0.39613019
160PTK2B0.39131900
161MAP3K50.39129861
162SGK30.38221027
163AKT10.37841787
164CAMK40.37128524
165RPS6KA50.37112634
166CSNK1D0.35543775
167AURKB0.35473529
168STK380.34837655
169RPS6KA40.34112704
170CSNK2A10.33965720

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.76282467
2DNA replication_Homo sapiens_hsa030302.98338906
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.96153655
4Homologous recombination_Homo sapiens_hsa034402.87885241
5Basal transcription factors_Homo sapiens_hsa030222.83964193
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82591881
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.65415131
8One carbon pool by folate_Homo sapiens_hsa006702.61087783
9Mismatch repair_Homo sapiens_hsa034302.50877101
10Non-homologous end-joining_Homo sapiens_hsa034502.47016780
11Selenocompound metabolism_Homo sapiens_hsa004502.27318051
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10524814
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.01157192
14Nucleotide excision repair_Homo sapiens_hsa034201.94919502
15Base excision repair_Homo sapiens_hsa034101.85726433
16Nitrogen metabolism_Homo sapiens_hsa009101.85539758
17Vitamin B6 metabolism_Homo sapiens_hsa007501.82683417
18Herpes simplex infection_Homo sapiens_hsa051681.78098160
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.76393256
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.66016499
21Nicotine addiction_Homo sapiens_hsa050331.63556937
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59960286
23Graft-versus-host disease_Homo sapiens_hsa053321.59021055
24Allograft rejection_Homo sapiens_hsa053301.52797834
25Dorso-ventral axis formation_Homo sapiens_hsa043201.52739384
26Cell cycle_Homo sapiens_hsa041101.52251061
27RNA degradation_Homo sapiens_hsa030181.52144769
28Retinol metabolism_Homo sapiens_hsa008301.49001559
29Pyrimidine metabolism_Homo sapiens_hsa002401.46913995
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.46404809
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45979470
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41779110
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40319529
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39991257
35Propanoate metabolism_Homo sapiens_hsa006401.34546493
36RNA transport_Homo sapiens_hsa030131.34487866
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.32516501
38Proteasome_Homo sapiens_hsa030501.31874408
39Hematopoietic cell lineage_Homo sapiens_hsa046401.30974630
40Ether lipid metabolism_Homo sapiens_hsa005651.29527142
41Butanoate metabolism_Homo sapiens_hsa006501.27616931
42T cell receptor signaling pathway_Homo sapiens_hsa046601.27372094
43Olfactory transduction_Homo sapiens_hsa047401.25334376
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24627183
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24367986
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23114038
47B cell receptor signaling pathway_Homo sapiens_hsa046621.17839536
48Vitamin digestion and absorption_Homo sapiens_hsa049771.17694309
49RNA polymerase_Homo sapiens_hsa030201.16775324
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15222752
51Regulation of autophagy_Homo sapiens_hsa041401.14935525
52Measles_Homo sapiens_hsa051621.14241188
53Type II diabetes mellitus_Homo sapiens_hsa049301.11939566
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11433964
55Type I diabetes mellitus_Homo sapiens_hsa049401.09275924
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08784586
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08121321
58Purine metabolism_Homo sapiens_hsa002301.07857188
59ABC transporters_Homo sapiens_hsa020101.06771728
60Autoimmune thyroid disease_Homo sapiens_hsa053201.05503063
61Sphingolipid metabolism_Homo sapiens_hsa006001.04899855
62Circadian rhythm_Homo sapiens_hsa047101.03225695
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03207438
64Legionellosis_Homo sapiens_hsa051341.03092255
65Influenza A_Homo sapiens_hsa051641.00756040
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99885298
67Fatty acid biosynthesis_Homo sapiens_hsa000610.96121940
68Circadian entrainment_Homo sapiens_hsa047130.94760002
69p53 signaling pathway_Homo sapiens_hsa041150.94746474
70Glutamatergic synapse_Homo sapiens_hsa047240.93334674
71Rheumatoid arthritis_Homo sapiens_hsa053230.92737292
72Steroid biosynthesis_Homo sapiens_hsa001000.92137772
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91962176
74mRNA surveillance pathway_Homo sapiens_hsa030150.90818420
75mTOR signaling pathway_Homo sapiens_hsa041500.90470691
76Insulin secretion_Homo sapiens_hsa049110.90369272
77Arachidonic acid metabolism_Homo sapiens_hsa005900.89813095
78Phototransduction_Homo sapiens_hsa047440.89654234
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88469923
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.84065979
81Ovarian steroidogenesis_Homo sapiens_hsa049130.83838637
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82885619
83beta-Alanine metabolism_Homo sapiens_hsa004100.82445997
84Long-term depression_Homo sapiens_hsa047300.78091558
85Salivary secretion_Homo sapiens_hsa049700.78007617
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77864037
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77671319
88Staphylococcus aureus infection_Homo sapiens_hsa051500.77414112
89Lysine degradation_Homo sapiens_hsa003100.77343112
90Epstein-Barr virus infection_Homo sapiens_hsa051690.76162470
91Insulin resistance_Homo sapiens_hsa049310.74443476
92Serotonergic synapse_Homo sapiens_hsa047260.74434075
93Systemic lupus erythematosus_Homo sapiens_hsa053220.74228888
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73836773
95Peroxisome_Homo sapiens_hsa041460.73120695
96Malaria_Homo sapiens_hsa051440.70837730
97TNF signaling pathway_Homo sapiens_hsa046680.69578230
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.69573470
99Viral carcinogenesis_Homo sapiens_hsa052030.69298797
100Cholinergic synapse_Homo sapiens_hsa047250.68511080
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65842602
102GABAergic synapse_Homo sapiens_hsa047270.65514284
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65492237
104Osteoclast differentiation_Homo sapiens_hsa043800.64917813
105Phagosome_Homo sapiens_hsa041450.64421534
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64168650
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.63858378
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62707349
109Glycerolipid metabolism_Homo sapiens_hsa005610.62485887
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.62193866
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60593220
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.57282438
113Oxytocin signaling pathway_Homo sapiens_hsa049210.57192515
114Complement and coagulation cascades_Homo sapiens_hsa046100.55543641
115Dopaminergic synapse_Homo sapiens_hsa047280.54206448
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54191559
117TGF-beta signaling pathway_Homo sapiens_hsa043500.54050572
118Amphetamine addiction_Homo sapiens_hsa050310.53213607
119Chemokine signaling pathway_Homo sapiens_hsa040620.52718236
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.52543760
121cAMP signaling pathway_Homo sapiens_hsa040240.52396248
122Choline metabolism in cancer_Homo sapiens_hsa052310.51803273
123Antigen processing and presentation_Homo sapiens_hsa046120.51151674
124Inositol phosphate metabolism_Homo sapiens_hsa005620.50018106
125MAPK signaling pathway_Homo sapiens_hsa040100.48929811
126Sulfur relay system_Homo sapiens_hsa041220.48895379
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48716768
128Prolactin signaling pathway_Homo sapiens_hsa049170.48703670
129Fatty acid elongation_Homo sapiens_hsa000620.46956586
130Platelet activation_Homo sapiens_hsa046110.46424853
131Primary immunodeficiency_Homo sapiens_hsa053400.43979214
132Gastric acid secretion_Homo sapiens_hsa049710.43225464
133HTLV-I infection_Homo sapiens_hsa051660.37507568
134Arginine and proline metabolism_Homo sapiens_hsa003300.37328026
135Leishmaniasis_Homo sapiens_hsa051400.37001892
136Hepatitis C_Homo sapiens_hsa051600.35986851
137Tryptophan metabolism_Homo sapiens_hsa003800.34891141
138Tuberculosis_Homo sapiens_hsa051520.34132082
139FoxO signaling pathway_Homo sapiens_hsa040680.32764110
140Calcium signaling pathway_Homo sapiens_hsa040200.32753469
141Linoleic acid metabolism_Homo sapiens_hsa005910.32239252
142Spliceosome_Homo sapiens_hsa030400.32078384
143Collecting duct acid secretion_Homo sapiens_hsa049660.31841995
144Taste transduction_Homo sapiens_hsa047420.30166882
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29563769
146Pentose phosphate pathway_Homo sapiens_hsa000300.29450528
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28761725
148Morphine addiction_Homo sapiens_hsa050320.28727146
149African trypanosomiasis_Homo sapiens_hsa051430.28277503
150Asthma_Homo sapiens_hsa053100.26957311
151Alcoholism_Homo sapiens_hsa050340.26463390

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