ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oocyte development (GO:0048599)	6.57134282
2	male meiosis I (GO:0007141)	6.41556383
3	multicellular organism reproduction (GO:0032504)	5.98436729
4	regulation of exit from mitosis (GO:0007096)	5.72213489
5	histone lysine demethylation (GO:0070076)	5.65837421
6	regulation of acrosome reaction (GO:0060046)	5.57671121
7	histone demethylation (GO:0016577)	5.39699353
8	meiosis I (GO:0007127)	5.33749880
9	synaptonemal complex organization (GO:0070193)	5.22694999
10	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.98831485
11	synaptonemal complex assembly (GO:0007130)	4.97717369
12	regulation of RIG-I signaling pathway (GO:0039535)	4.93064786
13	protein demethylation (GO:0006482)	4.87633490
14	protein dealkylation (GO:0008214)	4.87633490
15	N-terminal protein amino acid acetylation (GO:0006474)	4.79254751
16	positive regulation of catecholamine secretion (GO:0033605)	4.76453758
17	positive regulation of meiosis (GO:0045836)	4.67450977
18	male meiosis (GO:0007140)	4.61149557
19	positive regulation of meiotic cell cycle (GO:0051446)	4.58528728
20	regulation of female receptivity (GO:0045924)	4.58441233
21	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.46108010
22	gonadal mesoderm development (GO:0007506)	4.39498748
23	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	4.38022115
24	transcription from mitochondrial promoter (GO:0006390)	4.37005621
25	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	4.30659487
26	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	4.18823799
27	single fertilization (GO:0007338)	3.99009687
28	reproduction (GO:0000003)	3.98521537
29	response to UV-C (GO:0010225)	3.96189085
30	female mating behavior (GO:0060180)	3.92870260
31	regulation of uterine smooth muscle contraction (GO:0070472)	3.84946632
32	aggressive behavior (GO:0002118)	3.77552775
33	binding of sperm to zona pellucida (GO:0007339)	3.76488098
34	acrosome reaction (GO:0007340)	3.67376896
35	negative regulation of Ras GTPase activity (GO:0034261)	3.65857497
36	drinking behavior (GO:0042756)	3.63332066
37	regulation of DNA methylation (GO:0044030)	3.61580078
38	protein K6-linked ubiquitination (GO:0085020)	3.61448070
39	maturation of SSU-rRNA (GO:0030490)	3.58123635
40	mitotic metaphase plate congression (GO:0007080)	3.51433602
41	negative regulation of reproductive process (GO:2000242)	3.42933701
42	positive regulation of histone H3-K4 methylation (GO:0051571)	3.42889701
43	meiotic cell cycle (GO:0051321)	3.41948179
44	protein kinase C signaling (GO:0070528)	3.41389256
45	hyperosmotic salinity response (GO:0042538)	3.39652699
46	regulation of penile erection (GO:0060405)	3.38892894
47	positive regulation of digestive system process (GO:0060456)	3.33873794
48	piRNA metabolic process (GO:0034587)	3.33536635
49	meiotic cell cycle process (GO:1903046)	3.31060708
50	regulation of helicase activity (GO:0051095)	3.27812120
51	mitochondrial RNA metabolic process (GO:0000959)	3.26724323
52	regulation of histone H3-K9 methylation (GO:0051570)	3.26719436
53	regulation of female gonad development (GO:2000194)	3.26098680
54	chromosome organization involved in meiosis (GO:0070192)	3.25876981
55	positive regulation of prostaglandin secretion (GO:0032308)	3.19691701
56	fertilization (GO:0009566)	3.16794715
57	regulation of meiosis (GO:0040020)	3.16033702
58	negative regulation of digestive system process (GO:0060457)	3.15615730
59	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.14703243
60	intestinal epithelial cell development (GO:0060576)	3.03521238
61	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	25.0297530
62	regulation of retinoic acid receptor signaling pathway (GO:0048385)	20.9755344
63	sleep (GO:0030431)	2.99608730
64	protein K48-linked deubiquitination (GO:0071108)	2.98973021
65	autophagic vacuole assembly (GO:0000045)	2.98876686
66	positive regulation of humoral immune response (GO:0002922)	2.98847967
67	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.96346924
68	meiotic nuclear division (GO:0007126)	2.93851182
69	sperm-egg recognition (GO:0035036)	2.91198234
70	RNA localization (GO:0006403)	2.91072694
71	attachment of spindle microtubules to kinetochore (GO:0008608)	2.85227421
72	mitotic chromosome condensation (GO:0007076)	2.79202545
73	positive regulation of reproductive process (GO:2000243)	2.77980961
74	centriole replication (GO:0007099)	2.70080483
75	negative regulation of mRNA processing (GO:0050686)	2.67233804
76	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.66707001
77	DNA replication-dependent nucleosome organization (GO:0034723)	2.64231759
78	DNA replication-dependent nucleosome assembly (GO:0006335)	2.64231759
79	regulation of RNA splicing (GO:0043484)	2.64058540
80	regulation of mRNA processing (GO:0050684)	2.62712379
81	regulation of meiotic cell cycle (GO:0051445)	2.60837779
82	ventricular cardiac muscle cell development (GO:0055015)	2.60440180
83	regulation of prostaglandin secretion (GO:0032306)	2.60255603
84	N-terminal protein amino acid modification (GO:0031365)	2.60044028
85	demethylation (GO:0070988)	2.59308340
86	regulation of G0 to G1 transition (GO:0070316)	2.59212186
87	metaphase plate congression (GO:0051310)	2.58947343
88	poly(A)+ mRNA export from nucleus (GO:0016973)	2.55539478
89	calcium ion-dependent exocytosis (GO:0017156)	2.53550385
90	maternal behavior (GO:0042711)	2.50525260
91	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.42373934
92	citrulline biosynthetic process (GO:0019240)	2.42056718
93	rRNA modification (GO:0000154)	2.42004071
94	response to prostaglandin (GO:0034694)	2.41471041
95	DNA methylation involved in gamete generation (GO:0043046)	2.38289507
96	negative regulation of histone modification (GO:0031057)	2.38234645
97	regulation of mRNA metabolic process (GO:1903311)	2.35737297
98	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.35420100
99	spermatid development (GO:0007286)	2.35032244
100	histone H3-K9 demethylation (GO:0033169)	14.0002238

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	7.94426398
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.33191643
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	5.08171562
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.91414558
5	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.70727196
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.67142395
7	E2F7_22180533_ChIP-Seq_HELA_Human	3.26121840
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.05634929
9	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.96665015
10	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.96665015
11	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.96665015
12	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.91322182
13	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.83004409
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.65896732
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.61741288
16	VDR_22108803_ChIP-Seq_LS180_Human	2.48177680
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.34294266
18	AR_21909140_ChIP-Seq_LNCAP_Human	2.30753673
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.11861348
20	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.07895161
21	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02719382
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.01243296
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.99178334
24	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.94413506
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.91028035
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.89151576
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.85799963
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.81619053
29	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.80576684
30	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.72175877
31	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.71599046
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.69408182
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62697158
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.61639071
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.56229811
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.47255569
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40676876
38	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.39921452
39	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.37229369
40	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.36773599
41	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.35297961
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35141603
43	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.34737292
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.34087348
45	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.33654612
46	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.29287948
47	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28509208
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26833027
49	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.26293944
50	CBP_21632823_ChIP-Seq_H3396_Human	1.24980583
51	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.22866390
52	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.22812339
53	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.22106724
54	NCOR_22424771_ChIP-Seq_293T_Human	1.21564125
55	TCF4_23295773_ChIP-Seq_U87_Human	1.21116684
56	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.18533436
57	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.17733294
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14589470
59	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14079234
60	RAC3_21632823_ChIP-Seq_H3396_Human	1.13558913
61	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11376342
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.09919266
63	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08915331
64	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.07689747
65	GATA3_26560356_Chip-Seq_TH1_Human	1.06550007
66	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04286472
67	GF1_26923725_Chip-Seq_HPCs_Mouse	1.02741390
68	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.00065267
69	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.99588592
70	FOXP3_21729870_ChIP-Seq_TREG_Human	0.99118306
71	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98526483
72	STAT3_23295773_ChIP-Seq_U87_Human	0.96567038
73	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.95346189
74	VDR_23849224_ChIP-Seq_CD4+_Human	0.95308736
75	AR_25329375_ChIP-Seq_VCAP_Human	0.92889693
76	P300_19829295_ChIP-Seq_ESCs_Human	0.90390982
77	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.90045453
78	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.88568140
79	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.87936776
80	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.87654468
81	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.87382993
82	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.86857476
83	RXR_22108803_ChIP-Seq_LS180_Human	0.85785456
84	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.85331192
85	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.85314116
86	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.85184462
87	TBL1_22424771_ChIP-Seq_293T_Human	0.84717326
88	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.84552858
89	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.84515150
90	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.84165100
91	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.83091261
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.82445281
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.81870234
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.81386249
95	TAF15_26573619_Chip-Seq_HEK293_Human	0.80125181
96	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.80082538
97	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.79903379
98	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.79421775
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.77942504
100	BCAT_22108803_ChIP-Seq_LS180_Human	0.77778890

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	6.21797421
2	MP0009379_abnormal_foot_pigmentation	4.29389851
3	MP0003693_abnormal_embryo_hatching	4.16580760
4	MP0003283_abnormal_digestive_organ	3.45042931
5	MP0002160_abnormal_reproductive_system	3.27131963
6	MP0001986_abnormal_taste_sensitivity	3.18329506
7	MP0003950_abnormal_plasma_membrane	3.06759613
8	MP0003718_maternal_effect	3.04882596
9	MP0003136_yellow_coat_color	2.92066063
10	MP0000678_abnormal_parathyroid_gland	2.88466730
11	MP0005423_abnormal_somatic_nervous	2.82162864
12	MP0005410_abnormal_fertilization	2.73961436
13	MP0008058_abnormal_DNA_repair	2.63908712
14	MP0009840_abnormal_foam_cell	2.56388090
15	MP0001929_abnormal_gametogenesis	2.54204308
16	MP0002210_abnormal_sex_determination	2.26424090
17	MP0006276_abnormal_autonomic_nervous	2.24918939
18	MP0010094_abnormal_chromosome_stability	2.06415001
19	MP0003077_abnormal_cell_cycle	1.99270650
20	MP0005360_urolithiasis	1.92179426
21	MP0003699_abnormal_female_reproductive	1.91498788
22	MP0003111_abnormal_nucleus_morphology	1.85191803
23	MP0000427_abnormal_hair_cycle	1.84028672
24	MP0003119_abnormal_digestive_system	1.83174525
25	MP0001502_abnormal_circadian_rhythm	1.82632546
26	MP0010307_abnormal_tumor_latency	1.81802077
27	MP0008877_abnormal_DNA_methylation	1.79018506
28	MP0004957_abnormal_blastocyst_morpholog	1.76748643
29	MP0005389_reproductive_system_phenotype	1.76346753
30	MP0003890_abnormal_embryonic-extraembry	1.71247187
31	MP0000049_abnormal_middle_ear	1.66214931
32	MP0005647_abnormal_sex_gland	1.63284287
33	MP0002127_abnormal_cardiovascular_syste	1.63200395
34	MP0002277_abnormal_respiratory_mucosa	1.59529437
35	MP0005220_abnormal_exocrine_pancreas	1.59416707
36	MP0001666_abnormal_nutrient_absorption	1.58941646
37	MP0000653_abnormal_sex_gland	1.55080351
38	MP0002751_abnormal_autonomic_nervous	1.49890875
39	MP0001730_embryonic_growth_arrest	1.47910662
40	MP0003698_abnormal_male_reproductive	1.44204702
41	MP0005394_taste/olfaction_phenotype	1.43737461
42	MP0005499_abnormal_olfactory_system	1.43737461
43	MP0010030_abnormal_orbit_morphology	1.40594770
44	MP0002161_abnormal_fertility/fecundity	1.37470981
45	MP0003938_abnormal_ear_development	1.33978250
46	MP0001664_abnormal_digestion	1.31781124
47	MP0001145_abnormal_male_reproductive	1.28282242
48	MP0005646_abnormal_pituitary_gland	1.27991343
49	MP0000350_abnormal_cell_proliferation	1.20881852
50	MP0003183_abnormal_peptide_metabolism	1.19075000
51	MP0001119_abnormal_female_reproductive	1.18593693
52	MP0003866_abnormal_defecation	1.14251422
53	MP0001881_abnormal_mammary_gland	1.10546583
54	MP0004233_abnormal_muscle_weight	1.09565379
55	MP0003868_abnormal_feces_composition	1.06490730
56	MP0003121_genomic_imprinting	1.05736861
57	MP0003936_abnormal_reproductive_system	1.05593403
58	MP0002163_abnormal_gland_morphology	1.03972937
59	MP0003646_muscle_fatigue	1.02893344
60	MP0001286_abnormal_eye_development	1.02153556
61	MP0000372_irregular_coat_pigmentation	0.96827872
62	MP0008789_abnormal_olfactory_epithelium	0.95719308
63	MP0005380_embryogenesis_phenotype	0.92946582
64	MP0001672_abnormal_embryogenesis/_devel	0.92946582
65	MP0000631_abnormal_neuroendocrine_gland	0.90493667
66	MP0008932_abnormal_embryonic_tissue	0.90301474
67	MP0000462_abnormal_digestive_system	0.87055659
68	MP0000470_abnormal_stomach_morphology	0.83598544
69	MP0000428_abnormal_craniofacial_morphol	0.82231077
70	MP0002085_abnormal_embryonic_tissue	0.80853748
71	MP0005395_other_phenotype	0.78645774
72	MP0001440_abnormal_grooming_behavior	0.78146944
73	MP0002102_abnormal_ear_morphology	0.75035351
74	MP0008057_abnormal_DNA_replication	0.71520337
75	MP0001293_anophthalmia	0.69021550
76	MP0010368_abnormal_lymphatic_system	0.67235244
77	MP0002084_abnormal_developmental_patter	0.65859183
78	MP0003879_abnormal_hair_cell	0.64899712
79	MP0002090_abnormal_vision	0.64145185
80	MP0004043_abnormal_pH_regulation	0.63973571
81	MP0001697_abnormal_embryo_size	0.62270118
82	MP0006072_abnormal_retinal_apoptosis	0.62179431
83	MP0008260_abnormal_autophagy	0.61563600
84	MP0002396_abnormal_hematopoietic_system	0.59714864
85	MP0000627_abnormal_mammary_gland	0.58487247
86	MP0003935_abnormal_craniofacial_develop	0.58012998
87	MP0000230_abnormal_systemic_arterial	0.57884440
88	MP0002233_abnormal_nose_morphology	0.56194783
89	MP0005197_abnormal_uvea_morphology	0.56019707
90	MP0003984_embryonic_growth_retardation	0.55760616
91	MP0002229_neurodegeneration	0.55180713
92	MP0008995_early_reproductive_senescence	0.54686721
93	MP0002184_abnormal_innervation	0.54195866
94	MP0002873_normal_phenotype	0.53303437
95	MP0002169_no_abnormal_phenotype	0.53185105
96	MP0004742_abnormal_vestibular_system	0.53040205
97	MP0002088_abnormal_embryonic_growth/wei	0.52928721
98	MP0006036_abnormal_mitochondrial_physio	0.51346291
99	MP0004381_abnormal_hair_follicle	0.50726034
100	MP0000647_abnormal_sebaceous_gland	0.50715907

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	7.48750401
2	Male infertility (HP:0003251)	5.20959337
3	Short tibia (HP:0005736)	4.92904275
4	Median cleft lip (HP:0000161)	4.74525368
5	Aplasia/Hypoplasia of the tibia (HP:0005772)	4.74257673
6	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.23079624
7	Facial cleft (HP:0002006)	4.14775289
8	Abnormal number of incisors (HP:0011064)	4.13828237
9	Microglossia (HP:0000171)	3.94477419
10	Abnormality of abdominal situs (HP:0011620)	3.87659814
11	Abdominal situs inversus (HP:0003363)	3.87659814
12	Impulsivity (HP:0100710)	3.47126575
13	Abnormal pancreas size (HP:0012094)	3.34925647
14	Tetraparesis (HP:0002273)	3.25117098
15	Oligodactyly (hands) (HP:0001180)	3.20566014
16	Abnormality of the nasal septum (HP:0000419)	3.10416428
17	Tetany (HP:0001281)	3.07461850
18	Microretrognathia (HP:0000308)	3.04010581
19	Hyperphosphatemia (HP:0002905)	2.98144226
20	Glossoptosis (HP:0000162)	2.97760553
21	Abnormal auditory evoked potentials (HP:0006958)	2.96358464
22	Atonic seizures (HP:0010819)	2.93858869
23	Birth length less than 3rd percentile (HP:0003561)	2.90897097
24	Metaphyseal dysplasia (HP:0100255)	2.89317076
25	Reticulocytopenia (HP:0001896)	2.79558464
26	Congenital sensorineural hearing impairment (HP:0008527)	2.79070914
27	Maternal diabetes (HP:0009800)	2.75777564
28	Double outlet right ventricle (HP:0001719)	2.74563273
29	Congenital malformation of the right heart (HP:0011723)	2.74563273
30	Multiple enchondromatosis (HP:0005701)	2.62172414
31	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.51876776
32	Short chin (HP:0000331)	2.51803735
33	Anhidrosis (HP:0000970)	2.51372803
34	Adrenal hypoplasia (HP:0000835)	2.51021332
35	Ectopic kidney (HP:0000086)	2.49917239
36	Chromsome breakage (HP:0040012)	2.45953307
37	Rhinitis (HP:0012384)	2.42321617
38	Sensory axonal neuropathy (HP:0003390)	2.40051654
39	Abnormality of the fetal cardiovascular system (HP:0010948)	2.36132277
40	Abnormal umbilical cord blood vessels (HP:0011403)	2.36132277
41	Single umbilical artery (HP:0001195)	2.36132277
42	Hypophosphatemic rickets (HP:0004912)	2.33953176
43	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.29315555
44	Preauricular pit (HP:0004467)	2.29037057
45	Periauricular skin pits (HP:0100277)	2.29037057
46	Amelogenesis imperfecta (HP:0000705)	2.28745446
47	Abnormality of lateral ventricle (HP:0030047)	2.27336409
48	Absent thumb (HP:0009777)	2.27063810
49	Hypoplasia of the radius (HP:0002984)	2.26811961
50	Oligodactyly (HP:0012165)	2.24002889
51	Myokymia (HP:0002411)	2.23192977
52	Abnormal ciliary motility (HP:0012262)	2.22860977
53	Osteomalacia (HP:0002749)	2.22342896
54	Abnormality of cells of the erythroid lineage (HP:0012130)	2.20409167
55	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.19054733
56	Cleft eyelid (HP:0000625)	2.18869020
57	Abnormality of the incisor (HP:0000676)	2.17981566
58	Meckel diverticulum (HP:0002245)	2.17204209
59	Abnormality of the labia minora (HP:0012880)	2.15528179
60	Submucous cleft hard palate (HP:0000176)	2.14822096
61	Abnormality of chromosome stability (HP:0003220)	2.14671104
62	Abnormality of the ileum (HP:0001549)	2.12438500
63	Abnormality of the preputium (HP:0100587)	2.12153809
64	Infertility (HP:0000789)	2.12080382
65	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.11873822
66	Patent foramen ovale (HP:0001655)	2.10993448
67	Hypercortisolism (HP:0001578)	2.09494242
68	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.08138144
69	Short thumb (HP:0009778)	2.07671188
70	Anterior segment dysgenesis (HP:0007700)	2.07071250
71	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.06190645
72	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.06190645
73	Carpal bone hypoplasia (HP:0001498)	2.05397454
74	Type I diabetes mellitus (HP:0100651)	1.99255043
75	Malnutrition (HP:0004395)	1.99247319
76	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98404621
77	Absent/shortened dynein arms (HP:0200106)	1.98404621
78	Abnormal respiratory motile cilium physiology (HP:0012261)	1.93979644
79	Supernumerary spleens (HP:0009799)	1.93736302
80	Partial agenesis of the corpus callosum (HP:0001338)	1.93462917
81	Pancreatic fibrosis (HP:0100732)	1.93004317
82	Abnormality of the corticospinal tract (HP:0002492)	1.90865643
83	Selective tooth agenesis (HP:0001592)	1.90549683
84	Genu varum (HP:0002970)	1.90105980
85	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.89766879
86	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.88916483
87	Autoimmune thrombocytopenia (HP:0001973)	1.84646768
88	Hypoplasia of the fovea (HP:0007750)	1.83556755
89	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.83556755
90	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.82986710
91	Absent radius (HP:0003974)	1.81400373
92	Pili torti (HP:0003777)	1.79091928
93	Abnormality of the septum pellucidum (HP:0007375)	1.78598329
94	Renal Fanconi syndrome (HP:0001994)	1.77493355
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.77188293
96	Horseshoe kidney (HP:0000085)	1.76546535
97	Constricted visual fields (HP:0001133)	1.75164007
98	Azoospermia (HP:0000027)	1.74834892
99	Abnormal number of erythroid precursors (HP:0012131)	1.73594685
100	Fused cervical vertebrae (HP:0002949)	1.73013547

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	6.42647154
2	CDK12	3.86392723
3	LATS2	3.53721837
4	CDK19	3.45096279
5	SRPK1	3.27506851
6	TNIK	3.01766543
7	PLK4	3.01412346
8	TESK2	2.95589285
9	BUB1	2.83700257
10	AURKA	2.77795169
11	TAOK3	2.46249161
12	CDC7	2.04151646
13	ZAK	1.96123666
14	VRK1	1.89131636
15	PBK	1.85379442
16	TTK	1.75305814
17	TLK1	1.69264238
18	PLK1	1.67536884
19	TRIM28	1.66350280
20	AURKB	1.62473205
21	STK39	1.60455129
22	ACVR1B	1.51278207
23	CHEK2	1.50051516
24	ICK	1.32595468
25	TEC	1.24177139
26	NUAK1	1.23388915
27	PKN1	1.22278691
28	LATS1	1.20219221
29	BMPR1B	1.19212946
30	WNK1	1.15018844
31	EPHA4	1.13284046
32	MELK	1.13022369
33	PIM2	1.11941683
34	CHEK1	1.07372502
35	STK24	1.03832026
36	NEK6	1.02571513
37	NLK	1.00993613
38	PLK3	1.00665896
39	CDK7	0.95165606
40	PIM1	0.92651192
41	BRSK1	0.89038876
42	STK3	0.87885297
43	MAP2K3	0.83955857
44	MAP3K3	0.82824082
45	BRSK2	0.77980690
46	CSNK1E	0.75322617
47	CDK9	0.74455059
48	RAF1	0.74244793
49	OXSR1	0.74144653
50	STK4	0.74095268
51	STK38L	0.70146302
52	VRK2	0.68809347
53	ARAF	0.68135564
54	PAK1	0.67503582
55	BRAF	0.66684462
56	CDK2	0.63754853
57	DYRK3	0.62145053
58	PLK2	0.61522794
59	MARK3	0.60653691
60	MARK2	0.57994003
61	CDK1	0.55764828
62	CAMK4	0.54989421
63	MTOR	0.53934637
64	CSNK2A1	0.52317860
65	SGK2	0.51864429
66	NEK2	0.51519567
67	ATM	0.51157365
68	BMX	0.49411766
69	CSNK2A2	0.48610553
70	MAP3K5	0.47771089
71	GSK3A	0.46858579
72	ATR	0.46817976
73	MAPKAPK2	0.45692015
74	PRKCI	0.45131412
75	NME1	0.45041226
76	STK10	0.45032366
77	PDK2	0.45026330
78	AKT2	0.42359752
79	PRKD1	0.40731650
80	PRKACB	0.39864512
81	GRK7	0.38062310
82	PAK2	0.36859777
83	RPS6KA1	0.36291115
84	BRD4	0.35622692
85	CSNK1D	0.35215039
86	WNK4	0.34578686
87	PRKACA	0.33342757
88	PRKG1	0.33078462
89	PIK3CA	0.32147603
90	DMPK	0.32123057
91	GSK3B	0.31945185
92	WNK3	0.31544460
93	EIF2AK3	0.30792976
94	MAPK1	0.29954856
95	ERBB4	0.29384139
96	GRK5	0.29311557
97	ILK	0.28652947
98	CAMK1	0.28494494
99	KDR	0.26920181
100	MAPK13	0.26872437

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	5.97648916
2	Ribosome_Homo sapiens_hsa03010	4.26772763
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.24559597
4	Basal transcription factors_Homo sapiens_hsa03022	3.98294369
5	RNA polymerase_Homo sapiens_hsa03020	3.03803076
6	Mismatch repair_Homo sapiens_hsa03430	2.89192185
7	mRNA surveillance pathway_Homo sapiens_hsa03015	2.85701818
8	RNA transport_Homo sapiens_hsa03013	2.70560203
9	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.53319116
10	Regulation of autophagy_Homo sapiens_hsa04140	2.34872507
11	Homologous recombination_Homo sapiens_hsa03440	2.31804867
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.22171101
13	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.13187601
14	Oocyte meiosis_Homo sapiens_hsa04114	2.10502857
15	Spliceosome_Homo sapiens_hsa03040	2.05798481
16	Cell cycle_Homo sapiens_hsa04110	1.99800272
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.87720548
18	Folate biosynthesis_Homo sapiens_hsa00790	1.78259626
19	Sulfur metabolism_Homo sapiens_hsa00920	1.77852414
20	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.76576457
21	DNA replication_Homo sapiens_hsa03030	1.66133832
22	Bile secretion_Homo sapiens_hsa04976	1.64996188
23	RNA degradation_Homo sapiens_hsa03018	1.62156219
24	p53 signaling pathway_Homo sapiens_hsa04115	1.57026184
25	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.46450167
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.40354095
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.35177674
28	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.15205671
29	Taste transduction_Homo sapiens_hsa04742	1.11791636
30	Olfactory transduction_Homo sapiens_hsa04740	1.04986497
31	Purine metabolism_Homo sapiens_hsa00230	1.01598776
32	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.93324939
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.88653505
34	Insulin secretion_Homo sapiens_hsa04911	0.87825820
35	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.87560090
36	Huntingtons disease_Homo sapiens_hsa05016	0.85166005
37	Retinol metabolism_Homo sapiens_hsa00830	0.83489679
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83456403
39	Linoleic acid metabolism_Homo sapiens_hsa00591	0.81334456
40	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.78683349
41	Phototransduction_Homo sapiens_hsa04744	0.77013858
42	Alcoholism_Homo sapiens_hsa05034	0.76763717
43	Base excision repair_Homo sapiens_hsa03410	0.74785973
44	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70120029
45	Herpes simplex infection_Homo sapiens_hsa05168	0.68523579
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.65931771
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.64611786
48	Serotonergic synapse_Homo sapiens_hsa04726	0.60022471
49	Viral carcinogenesis_Homo sapiens_hsa05203	0.59779188
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.59527813
51	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.59149685
52	Wnt signaling pathway_Homo sapiens_hsa04310	0.58205768
53	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.58193006
54	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.56958841
55	Circadian rhythm_Homo sapiens_hsa04710	0.51771163
56	MicroRNAs in cancer_Homo sapiens_hsa05206	0.51466659
57	Hippo signaling pathway_Homo sapiens_hsa04390	0.49982965
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46244080
59	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.46170552
60	Nicotine addiction_Homo sapiens_hsa05033	0.45029014
61	Tight junction_Homo sapiens_hsa04530	0.41742789
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41395732
63	GABAergic synapse_Homo sapiens_hsa04727	0.41367030
64	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.38541708
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.38509782
66	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38013235
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34776758
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.33924652
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.31888178
70	Colorectal cancer_Homo sapiens_hsa05210	0.31640079
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31534436
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29826571
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28405190
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.27094136
75	Protein digestion and absorption_Homo sapiens_hsa04974	0.25992646
76	Protein export_Homo sapiens_hsa03060	0.25880962
77	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.25789764
78	Caffeine metabolism_Homo sapiens_hsa00232	0.25226490
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.25009704
80	Gap junction_Homo sapiens_hsa04540	0.24992349
81	Adherens junction_Homo sapiens_hsa04520	0.24430057
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.23616880
83	Cholinergic synapse_Homo sapiens_hsa04725	0.23367952
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.22484587
85	Lysine degradation_Homo sapiens_hsa00310	0.21093835
86	Morphine addiction_Homo sapiens_hsa05032	0.21084337
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.18944399
88	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.17852967
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.17489363
90	Apoptosis_Homo sapiens_hsa04210	0.17181208
91	Fatty acid elongation_Homo sapiens_hsa00062	0.16473540
92	Glutathione metabolism_Homo sapiens_hsa00480	0.15743632
93	Legionellosis_Homo sapiens_hsa05134	0.15142746
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.14678493
95	AMPK signaling pathway_Homo sapiens_hsa04152	0.14541270
96	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.14504818
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.14488149
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.13994460
99	Cocaine addiction_Homo sapiens_hsa05030	0.13384704
100	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.11823507

TRIM53AP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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