ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oocyte development (GO:0048599)	8.00780083
2	histone lysine demethylation (GO:0070076)	7.26263902
3	synaptonemal complex organization (GO:0070193)	6.96673880
4	regulation of RIG-I signaling pathway (GO:0039535)	6.86593544
5	histone demethylation (GO:0016577)	6.84114254
6	positive regulation of meiosis (GO:0045836)	6.81962607
7	synaptonemal complex assembly (GO:0007130)	6.74807834
8	regulation of exit from mitosis (GO:0007096)	6.73026825
9	multicellular organism reproduction (GO:0032504)	6.68210570
10	positive regulation of meiotic cell cycle (GO:0051446)	6.45347989
11	gonadal mesoderm development (GO:0007506)	6.38036968
12	protein dealkylation (GO:0008214)	6.17512932
13	protein demethylation (GO:0006482)	6.17512932
14	negative regulation of Ras GTPase activity (GO:0034261)	6.15091593
15	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	6.05410603
16	positive regulation of catecholamine secretion (GO:0033605)	5.46684383
17	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.38589125
18	regulation of acrosome reaction (GO:0060046)	5.29735864
19	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	5.19147185
20	N-terminal protein amino acid acetylation (GO:0006474)	5.10398982
21	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	5.09837942
22	acrosome reaction (GO:0007340)	5.02635390
23	protein K48-linked deubiquitination (GO:0071108)	5.00712398
24	single fertilization (GO:0007338)	4.87540508
25	regulation of female receptivity (GO:0045924)	4.66093564
26	male meiosis I (GO:0007141)	4.61445776
27	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.47644012
28	reproduction (GO:0000003)	4.37548410
29	male meiosis (GO:0007140)	4.31178733
30	chromosome organization involved in meiosis (GO:0070192)	4.27606140
31	regulation of retinoic acid receptor signaling pathway (GO:0048385)	4.26463528
32	regulation of uterine smooth muscle contraction (GO:0070472)	4.09039197
33	binding of sperm to zona pellucida (GO:0007339)	3.99703561
34	response to UV-C (GO:0010225)	3.95986599
35	female mating behavior (GO:0060180)	3.95791331
36	regulation of ruffle assembly (GO:1900027)	3.83738379
37	protein K63-linked deubiquitination (GO:0070536)	3.72090313
38	regulation of meiosis (GO:0040020)	3.70210620
39	trivalent inorganic anion homeostasis (GO:0072506)	3.68801697
40	phosphate ion homeostasis (GO:0055062)	3.68801697
41	meiosis I (GO:0007127)	3.65338025
42	mRNA transcription from RNA polymerase II promoter (GO:0042789)	3.64275557
43	fertilization (GO:0009566)	3.61615977
44	centriole replication (GO:0007099)	3.58031863
45	cilium movement (GO:0003341)	3.55304223
46	striated muscle atrophy (GO:0014891)	3.54048442
47	epithelial cilium movement (GO:0003351)	3.48598714
48	positive regulation of histone H3-K4 methylation (GO:0051571)	3.42823075
49	regulation of defense response to virus by host (GO:0050691)	3.41202004
50	protein K6-linked ubiquitination (GO:0085020)	3.39751685
51	intestinal epithelial cell development (GO:0060576)	3.37132015
52	piRNA metabolic process (GO:0034587)	3.34690729
53	peristalsis (GO:0030432)	3.33858539
54	aggressive behavior (GO:0002118)	3.32973992
55	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.30749302
56	citrulline biosynthetic process (GO:0019240)	3.29386469
57	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	3.28518426
58	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.27865499
59	negative regulation of inclusion body assembly (GO:0090084)	3.25267590
60	sperm-egg recognition (GO:0035036)	3.24740561
61	positive regulation of digestive system process (GO:0060456)	3.24667994
62	protein kinase C signaling (GO:0070528)	3.23600911
63	demethylation (GO:0070988)	3.23594286
64	tryptophan catabolic process (GO:0006569)	3.23019511
65	indole-containing compound catabolic process (GO:0042436)	3.23019511
66	indolalkylamine catabolic process (GO:0046218)	3.23019511
67	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.22146545
68	hyperosmotic salinity response (GO:0042538)	3.19386011
69	regulation of receptor binding (GO:1900120)	3.18793335
70	regulation of neurotransmitter uptake (GO:0051580)	3.15656393
71	positive regulation of skeletal muscle tissue development (GO:0048643)	3.15457576
72	organ formation (GO:0048645)	3.15342153
73	calcium ion-dependent exocytosis (GO:0017156)	3.14750031
74	regulation of helicase activity (GO:0051095)	3.14219978
75	sleep (GO:0030431)	3.13300282
76	spermatid development (GO:0007286)	3.12833675
77	meiotic cell cycle process (GO:1903046)	3.09158303
78	postsynaptic membrane organization (GO:0001941)	3.07478776
79	regulation of mRNA splicing, via spliceosome (GO:0048024)	3.06038100
80	muscle atrophy (GO:0014889)	3.05332892
81	behavioral response to nicotine (GO:0035095)	3.05256280
82	drinking behavior (GO:0042756)	3.04873881
83	negative regulation of reproductive process (GO:2000242)	3.03663655
84	indolalkylamine metabolic process (GO:0006586)	3.03613036
85	artery development (GO:0060840)	3.03240233
86	cellular anion homeostasis (GO:0030002)	3.03136930
87	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.02703386
88	pancreas development (GO:0031016)	3.02003450
89	regulation of meiotic cell cycle (GO:0051445)	3.00344326
90	ventricular system development (GO:0021591)	2.97248259
91	maternal behavior (GO:0042711)	2.96195593
92	microtubule severing (GO:0051013)	2.94717388
93	urate metabolic process (GO:0046415)	2.91794220
94	exocrine pancreas development (GO:0031017)	2.88617013
95	RNA localization (GO:0006403)	2.86722804
96	positive regulation of prostaglandin secretion (GO:0032308)	2.86528664
97	kynurenine metabolic process (GO:0070189)	2.86462123
98	regulation of penile erection (GO:0060405)	2.85628230
99	poly(A)+ mRNA export from nucleus (GO:0016973)	2.84474712
100	histone H3-K9 demethylation (GO:0033169)	18.8485319

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	7.49394971
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.43753669
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.96389243
4	VDR_22108803_ChIP-Seq_LS180_Human	3.80328361
5	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.34749607
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.27427733
7	GBX2_23144817_ChIP-Seq_PC3_Human	3.04972623
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.64732779
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.56902464
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.47443740
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.16737948
12	TOP2B_26459242_ChIP-Seq_MCF-7_Human	2.13496087
13	GATA1_22025678_ChIP-Seq_K562_Human	2.12201957
14	RXR_22108803_ChIP-Seq_LS180_Human	2.05726538
15	AUTS2_25519132_ChIP-Seq_293T-REX_Human	2.05531846
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.03475358
17	IRF1_19129219_ChIP-ChIP_H3396_Human	1.96704005
18	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.92116973
19	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.91371896
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.88218665
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83888172
22	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.82752102
23	TCF4_23295773_ChIP-Seq_U87_Human	1.82653423
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77535191
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.76755320
26	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.75807845
27	STAT3_23295773_ChIP-Seq_U87_Human	1.75385831
28	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.69452043
29	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.67825565
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66980083
31	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.66855369
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.66739645
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.65777646
34	P300_19829295_ChIP-Seq_ESCs_Human	1.65702594
35	AR_25329375_ChIP-Seq_VCAP_Human	1.65616646
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.63514874
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.61926973
38	CBP_21632823_ChIP-Seq_H3396_Human	1.60751022
39	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.59486311
40	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.59068919
41	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.58212498
42	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.57868069
43	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.57537944
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57181699
45	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.55500218
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53809899
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.52796691
48	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.52276594
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.52076368
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.48755500
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.48745643
52	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.47765947
53	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.46492578
54	MYC_18940864_ChIP-ChIP_HL60_Human	1.45103769
55	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44670028
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43283672
57	TAF15_26573619_Chip-Seq_HEK293_Human	1.43032088
58	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.41967768
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.41855216
60	ZNF274_21170338_ChIP-Seq_K562_Hela	1.41554082
61	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.40491322
62	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.38287641
63	NCOR_22424771_ChIP-Seq_293T_Human	1.36857394
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35723462
65	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.33973895
66	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.30401805
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27738126
68	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27708729
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.27483794
70	SMRT_27268052_Chip-Seq_Bcells_Human	1.21853761
71	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.21458438
72	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.21458438
73	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.19741119
74	GATA3_26560356_Chip-Seq_TH1_Human	1.16285546
75	FUS_26573619_Chip-Seq_HEK293_Human	1.14946161
76	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.14597224
77	GF1_26923725_Chip-Seq_HPCs_Mouse	1.14120578
78	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.13945544
79	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.12581833
80	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.12129574
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.10494391
82	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.10483733
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10343049
84	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.10058059
85	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.08403356
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07120124
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05838907
88	TP63_23658742_ChIP-Seq_EP156T_Human	1.04556246
89	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.02416083
90	AR_21572438_ChIP-Seq_LNCaP_Human	1.01701987
91	CJUN_26792858_Chip-Seq_BT549_Human	1.01056832
92	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00747800
93	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.00086634
94	AR_21909140_ChIP-Seq_LNCAP_Human	0.97079147
95	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.96736675
96	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96458805
97	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.96384722
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.96370705
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.96297369
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.95094242

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.71183983
2	MP0003283_abnormal_digestive_organ	5.49773361
3	MP0000678_abnormal_parathyroid_gland	3.90453266
4	MP0003950_abnormal_plasma_membrane	3.86493541
5	MP0003136_yellow_coat_color	3.75003072
6	MP0002160_abnormal_reproductive_system	3.59837282
7	MP0009379_abnormal_foot_pigmentation	3.52996349
8	MP0000427_abnormal_hair_cycle	3.36360284
9	MP0005410_abnormal_fertilization	2.88232593
10	MP0003693_abnormal_embryo_hatching	2.81384496
11	MP0006276_abnormal_autonomic_nervous	2.63055038
12	MP0008058_abnormal_DNA_repair	2.42380337
13	MP0009840_abnormal_foam_cell	2.41764991
14	MP0001502_abnormal_circadian_rhythm	2.33351341
15	MP0001929_abnormal_gametogenesis	2.30715490
16	MP0005220_abnormal_exocrine_pancreas	2.25378718
17	MP0004233_abnormal_muscle_weight	2.19208248
18	MP0005360_urolithiasis	2.14031369
19	MP0003119_abnormal_digestive_system	2.12836290
20	MP0003183_abnormal_peptide_metabolism	2.11523550
21	MP0001664_abnormal_digestion	2.05491828
22	MP0002210_abnormal_sex_determination	1.91168290
23	MP0002751_abnormal_autonomic_nervous	1.79334980
24	MP0003699_abnormal_female_reproductive	1.77950698
25	MP0003866_abnormal_defecation	1.74942995
26	MP0001666_abnormal_nutrient_absorption	1.70987531
27	MP0005389_reproductive_system_phenotype	1.65878723
28	MP0000049_abnormal_middle_ear	1.64364081
29	MP0003868_abnormal_feces_composition	1.62629146
30	MP0005647_abnormal_sex_gland	1.62417927
31	MP0006072_abnormal_retinal_apoptosis	1.59055720
32	MP0003890_abnormal_embryonic-extraembry	1.48549126
33	MP0010094_abnormal_chromosome_stability	1.39614924
34	MP0000653_abnormal_sex_gland	1.36852435
35	MP0003698_abnormal_male_reproductive	1.33763271
36	MP0001501_abnormal_sleep_pattern	1.25864990
37	MP0008877_abnormal_DNA_methylation	1.24406313
38	MP0005646_abnormal_pituitary_gland	1.20845138
39	MP0004043_abnormal_pH_regulation	1.20748525
40	MP0001119_abnormal_female_reproductive	1.20613765
41	MP0002277_abnormal_respiratory_mucosa	1.18642795
42	MP0000470_abnormal_stomach_morphology	1.17329538
43	MP0001440_abnormal_grooming_behavior	1.10765956
44	MP0002161_abnormal_fertility/fecundity	1.09463696
45	MP0000230_abnormal_systemic_arterial	1.08690647
46	MP0001145_abnormal_male_reproductive	1.07276541
47	MP0000534_abnormal_ureter_morphology	1.05842154
48	MP0003936_abnormal_reproductive_system	1.05621526
49	MP0002184_abnormal_innervation	1.05354096
50	MP0000631_abnormal_neuroendocrine_gland	1.04395383
51	MP0003938_abnormal_ear_development	1.03566680
52	MP0005551_abnormal_eye_electrophysiolog	1.02236234
53	MP0002272_abnormal_nervous_system	1.00828369
54	MP0004742_abnormal_vestibular_system	0.98813250
55	MP0000778_abnormal_nervous_system	0.98043485
56	MP0003959_abnormal_lean_body	0.93446806
57	MP0002229_neurodegeneration	0.90060993
58	MP0001286_abnormal_eye_development	0.89550032
59	MP0000372_irregular_coat_pigmentation	0.88600782
60	MP0009745_abnormal_behavioral_response	0.87884213
61	MP0010368_abnormal_lymphatic_system	0.87038021
62	MP0002249_abnormal_larynx_morphology	0.86880319
63	MP0005645_abnormal_hypothalamus_physiol	0.86822535
64	MP0002090_abnormal_vision	0.84996412
65	MP0005623_abnormal_meninges_morphology	0.82616800
66	MP0010307_abnormal_tumor_latency	0.80949750
67	MP0009765_abnormal_xenobiotic_induced	0.80812668
68	MP0002102_abnormal_ear_morphology	0.78958430
69	MP0001944_abnormal_pancreas_morphology	0.78487649
70	MP0005253_abnormal_eye_physiology	0.76363178
71	MP0003077_abnormal_cell_cycle	0.76343832
72	MP0003880_abnormal_central_pattern	0.73256382
73	MP0002067_abnormal_sensory_capabilities	0.72023100
74	MP0000462_abnormal_digestive_system	0.71973472
75	MP0001485_abnormal_pinna_reflex	0.70577411
76	MP0002693_abnormal_pancreas_physiology	0.70197244
77	MP0002396_abnormal_hematopoietic_system	0.69961250
78	MP0009703_decreased_birth_body	0.68307182
79	MP0005334_abnormal_fat_pad	0.67087891
80	MP0003718_maternal_effect	0.66507067
81	MP0001730_embryonic_growth_arrest	0.66168703
82	MP0005076_abnormal_cell_differentiation	0.64044766
83	MP0002734_abnormal_mechanical_nocicepti	0.63163755
84	MP0002163_abnormal_gland_morphology	0.62501153
85	MP0001963_abnormal_hearing_physiology	0.62321909
86	MP0003879_abnormal_hair_cell	0.61124301
87	MP0000647_abnormal_sebaceous_gland	0.60401438
88	MP0002332_abnormal_exercise_endurance	0.58095849
89	MP0000569_abnormal_digit_pigmentation	0.57903818
90	MP0002127_abnormal_cardiovascular_syste	0.57872387
91	MP0000428_abnormal_craniofacial_morphol	0.55881781
92	MP0000026_abnormal_inner_ear	0.54698477
93	MP0009384_cardiac_valve_regurgitation	0.54589661
94	MP0002837_dystrophic_cardiac_calcinosis	0.54016651
95	MP0009046_muscle_twitch	0.52881322
96	MP0001881_abnormal_mammary_gland	0.50618121
97	MP0001968_abnormal_touch/_nociception	0.50275088
98	MP0002882_abnormal_neuron_morphology	0.50111305
99	MP0005195_abnormal_posterior_eye	0.49501981
100	MP0000350_abnormal_cell_proliferation	0.48953010

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	7.30554358
2	Median cleft lip (HP:0000161)	5.63340532
3	Microglossia (HP:0000171)	4.89473032
4	Aplasia/Hypoplasia of the tibia (HP:0005772)	4.77221555
5	Short tibia (HP:0005736)	4.68771105
6	Abnormal number of incisors (HP:0011064)	4.35518998
7	Oligodactyly (hands) (HP:0001180)	4.35133324
8	Atonic seizures (HP:0010819)	3.97391819
9	Pancreatic fibrosis (HP:0100732)	3.87171291
10	Congenital sensorineural hearing impairment (HP:0008527)	3.78029219
11	Abnormal auditory evoked potentials (HP:0006958)	3.75877539
12	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.71020464
13	Abnormality of the nasal septum (HP:0000419)	3.64480616
14	Facial cleft (HP:0002006)	3.62042362
15	Tetany (HP:0001281)	3.58648498
16	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.55507245
17	Amelogenesis imperfecta (HP:0000705)	3.51914869
18	Hyperphosphatemia (HP:0002905)	3.38930837
19	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.37392737
20	Metaphyseal dysplasia (HP:0100255)	3.31432935
21	Adrenal hypoplasia (HP:0000835)	3.15027242
22	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.08309695
23	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.08309695
24	Tetraparesis (HP:0002273)	3.04293023
25	Autoimmune thrombocytopenia (HP:0001973)	2.84581457
26	Submucous cleft hard palate (HP:0000176)	2.82684247
27	Abnormality of the corticospinal tract (HP:0002492)	2.82391231
28	Abnormality of the incisor (HP:0000676)	2.80139883
29	Abnormality of dental color (HP:0011073)	2.79507437
30	Maternal diabetes (HP:0009800)	2.78863715
31	Short chin (HP:0000331)	2.77554809
32	Impulsivity (HP:0100710)	2.77262034
33	Abnormality of the frontal sinuses (HP:0002687)	2.72889969
34	Oligodactyly (HP:0012165)	2.71763241
35	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.71448167
36	Abnormal ciliary motility (HP:0012262)	2.69778995
37	Abnormality of abdominal situs (HP:0011620)	2.60464053
38	Abdominal situs inversus (HP:0003363)	2.60464053
39	Partial agenesis of the corpus callosum (HP:0001338)	2.57338464
40	Microretrognathia (HP:0000308)	2.50078313
41	Abnormal respiratory motile cilium physiology (HP:0012261)	2.45319314
42	Neurofibrillary tangles (HP:0002185)	2.35125152
43	Type I diabetes mellitus (HP:0100651)	2.32291240
44	Abnormality of chromosome stability (HP:0003220)	2.30882502
45	Ectopic kidney (HP:0000086)	2.29328356
46	Optic nerve hypoplasia (HP:0000609)	2.27547492
47	Hypoplasia of the iris (HP:0007676)	2.24188454
48	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.22847880
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.22785342
50	Absent/shortened dynein arms (HP:0200106)	2.22785342
51	Myokymia (HP:0002411)	2.22336615
52	Genital tract atresia (HP:0001827)	2.22175896
53	Mesangial abnormality (HP:0001966)	2.22009365
54	Loss of speech (HP:0002371)	2.21828601
55	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.18754927
56	Abnormality of the labia minora (HP:0012880)	2.17445929
57	Abnormality of lateral ventricle (HP:0030047)	2.16618896
58	Fair hair (HP:0002286)	2.14418188
59	Glossoptosis (HP:0000162)	2.13882389
60	True hermaphroditism (HP:0010459)	2.11634845
61	Abnormality of proline metabolism (HP:0010907)	2.10542931
62	Hydroxyprolinuria (HP:0003080)	2.10542931
63	Nonprogressive disorder (HP:0003680)	2.10524981
64	Anhidrosis (HP:0000970)	2.09289605
65	Male infertility (HP:0003251)	2.06370581
66	Decreased subcutaneous fat (HP:0001002)	2.06195562
67	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.06108086
68	Rhinitis (HP:0012384)	2.04179282
69	Abnormal pancreas size (HP:0012094)	2.02232646
70	Prostate neoplasm (HP:0100787)	2.01323307
71	Preaxial hand polydactyly (HP:0001177)	2.00711830
72	Exertional dyspnea (HP:0002875)	1.96119660
73	Abnormality of alanine metabolism (HP:0010916)	1.94339541
74	Hyperalaninemia (HP:0003348)	1.94339541
75	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.94339541
76	Disproportionate short-trunk short stature (HP:0003521)	1.92854555
77	Hypoventilation (HP:0002791)	1.90748619
78	Postaxial foot polydactyly (HP:0001830)	1.90104202
79	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89329499
80	Bony spicule pigmentary retinopathy (HP:0007737)	1.89235589
81	Gastrointestinal atresia (HP:0002589)	1.87029333
82	Hypoplasia of the radius (HP:0002984)	1.86447655
83	Medial flaring of the eyebrow (HP:0010747)	1.83806929
84	Chronic bronchitis (HP:0004469)	1.83714889
85	Bifid uvula (HP:0000193)	1.80587554
86	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.79494289
87	Autoimmune hemolytic anemia (HP:0001890)	1.78996007
88	Abnormality of cells of the erythroid lineage (HP:0012130)	1.77162178
89	Spastic diplegia (HP:0001264)	1.75508310
90	Birth length less than 3rd percentile (HP:0003561)	1.74598989
91	Poor coordination (HP:0002370)	1.73556421
92	Absent thumb (HP:0009777)	1.73485246
93	Congenital primary aphakia (HP:0007707)	1.72382393
94	Gait imbalance (HP:0002141)	1.71940159
95	Spinal muscular atrophy (HP:0007269)	1.68889465
96	Chromsome breakage (HP:0040012)	1.68763456
97	Diaphragmatic weakness (HP:0009113)	1.68501024
98	Short middle phalanx of the 5th finger (HP:0004220)	1.67749820
99	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.66716968
100	Neonatal onset (HP:0003623)	1.66218922

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	6.52321315
2	CDK12	4.30873988
3	TNIK	3.84770488
4	CDK19	3.23671527
5	PLK4	3.23636541
6	TAOK3	3.23310670
7	AURKA	2.69910791
8	VRK1	2.64092523
9	ICK	2.41699302
10	TSSK6	2.34611018
11	STK39	2.29755701
12	TLK1	2.19103265
13	ACVR1B	2.16042723
14	BMPR1B	2.09549981
15	ZAK	2.08939788
16	LATS2	1.90916891
17	NLK	1.82442441
18	TEC	1.69300577
19	MAP2K3	1.51367718
20	CDC7	1.50421991
21	EPHA4	1.37531649
22	MAPK15	1.30186182
23	MAP3K3	1.29771339
24	LATS1	1.28409231
25	INSRR	1.20093536
26	CHEK2	1.18575548
27	TTK	1.17165772
28	SGK2	1.15380170
29	GRK7	1.13197570
30	OXSR1	1.11136467
31	PIK3CA	1.09798425
32	FRK	1.09189592
33	PKN1	1.06688115
34	SRPK1	1.06264252
35	WNK1	1.03200356
36	NUAK1	1.00431219
37	PIM2	0.96414503
38	AURKB	0.94392607
39	CAMKK2	0.92079610
40	MARK2	0.89294766
41	PBK	0.87034652
42	MAPK13	0.84812879
43	PLK2	0.78941640
44	MELK	0.77893613
45	PLK1	0.77531450
46	STK38L	0.76194472
47	CAMK4	0.76083498
48	TYRO3	0.72213572
49	TESK2	0.66543971
50	WNK4	0.66177822
51	TRIM28	0.64346545
52	CAMK1D	0.61420496
53	GRK1	0.60708119
54	SGK223	0.58239361
55	SGK494	0.58239361
56	SGK3	0.56271440
57	PIM1	0.54855751
58	IRAK1	0.54281868
59	ARAF	0.54039001
60	CHEK1	0.53709794
61	JAK3	0.53363643
62	BRAF	0.52334765
63	GRK5	0.51975050
64	PRKD1	0.51447851
65	TGFBR1	0.51357222
66	STK24	0.50818654
67	MAPKAPK2	0.50616803
68	RPS6KA5	0.50105368
69	MOS	0.49091013
70	CAMK1	0.48040170
71	ADRBK2	0.47532999
72	PRKACA	0.42825356
73	CSNK1E	0.42194747
74	IRAK4	0.40289946
75	NTRK2	0.39621333
76	PRKACB	0.36802284
77	TIE1	0.36170527
78	STK3	0.35923556
79	CSNK1D	0.35918345
80	PIK3CG	0.34717303
81	VRK2	0.34644545
82	CDK7	0.34619652
83	TNK2	0.34334654
84	TBK1	0.31413892
85	TGFBR2	0.31307154
86	PTK2B	0.30358731
87	ILK	0.30216949
88	MAPK12	0.29731563
89	CDK2	0.28130454
90	PAK1	0.27605107
91	CAMK2A	0.26589199
92	ATM	0.26526230
93	TXK	0.26495862
94	PLK3	0.26342478
95	RPS6KA3	0.26031791
96	CDK1	0.26013308
97	NEK9	0.23850127
98	IKBKE	0.23774075
99	MTOR	0.23531547
100	ADRBK1	0.22732764

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	7.04348067
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.44927962
3	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.32139850
4	Bile secretion_Homo sapiens_hsa04976	2.59725496
5	Ribosome_Homo sapiens_hsa03010	2.56117007
6	Sulfur metabolism_Homo sapiens_hsa00920	2.51743670
7	Homologous recombination_Homo sapiens_hsa03440	2.48284588
8	Phototransduction_Homo sapiens_hsa04744	2.26699639
9	Mismatch repair_Homo sapiens_hsa03430	2.16370444
10	Linoleic acid metabolism_Homo sapiens_hsa00591	1.98080538
11	Retinol metabolism_Homo sapiens_hsa00830	1.83607646
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.82932001
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.78971593
14	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.71377095
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.69208957
16	Olfactory transduction_Homo sapiens_hsa04740	1.63228412
17	Chemical carcinogenesis_Homo sapiens_hsa05204	1.60266707
18	Basal transcription factors_Homo sapiens_hsa03022	1.54949420
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.42609701
20	Nicotine addiction_Homo sapiens_hsa05033	1.40181876
21	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.34485949
22	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.34290136
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.30118750
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.30054061
25	Insulin secretion_Homo sapiens_hsa04911	1.29258566
26	RNA polymerase_Homo sapiens_hsa03020	1.25560792
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.22121358
28	Cocaine addiction_Homo sapiens_hsa05030	1.19017511
29	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.17945815
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16846386
31	Alcoholism_Homo sapiens_hsa05034	1.15698590
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15588149
33	mRNA surveillance pathway_Homo sapiens_hsa03015	1.12405794
34	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.12097690
35	GABAergic synapse_Homo sapiens_hsa04727	1.07486759
36	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.05280197
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03869728
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.03571859
39	Oocyte meiosis_Homo sapiens_hsa04114	1.03526342
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.02910989
41	Taste transduction_Homo sapiens_hsa04742	1.01884525
42	RNA transport_Homo sapiens_hsa03013	0.99401363
43	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.97724984
44	Morphine addiction_Homo sapiens_hsa05032	0.95240873
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.93856643
46	Serotonergic synapse_Homo sapiens_hsa04726	0.93024661
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.90173480
48	cAMP signaling pathway_Homo sapiens_hsa04024	0.88903281
49	RNA degradation_Homo sapiens_hsa03018	0.80407929
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.79046787
51	Cholinergic synapse_Homo sapiens_hsa04725	0.78522664
52	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.76205891
53	Circadian rhythm_Homo sapiens_hsa04710	0.71999963
54	Butanoate metabolism_Homo sapiens_hsa00650	0.71000668
55	Renin-angiotensin system_Homo sapiens_hsa04614	0.69956970
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69264091
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67751816
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.67303081
59	Estrogen signaling pathway_Homo sapiens_hsa04915	0.65358084
60	Amphetamine addiction_Homo sapiens_hsa05031	0.59728611
61	Purine metabolism_Homo sapiens_hsa00230	0.58696556
62	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.57924602
63	Circadian entrainment_Homo sapiens_hsa04713	0.57809452
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.57684925
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57597650
66	Legionellosis_Homo sapiens_hsa05134	0.57496444
67	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.53910290
68	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.51888913
69	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.51703971
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.51146764
71	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.51134192
72	Hippo signaling pathway_Homo sapiens_hsa04390	0.47202664
73	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.41954123
74	Lysine degradation_Homo sapiens_hsa00310	0.41848539
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.40021795
76	Salivary secretion_Homo sapiens_hsa04970	0.39263340
77	Colorectal cancer_Homo sapiens_hsa05210	0.38756730
78	Spliceosome_Homo sapiens_hsa03040	0.37864772
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.37797401
80	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.36134881
81	Tight junction_Homo sapiens_hsa04530	0.34930476
82	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.34367475
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34108066
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.33288290
85	Gap junction_Homo sapiens_hsa04540	0.31736497
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.31546490
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30398525
88	Herpes simplex infection_Homo sapiens_hsa05168	0.29194762
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.29123807
90	ABC transporters_Homo sapiens_hsa02010	0.29047112
91	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.28957100
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.28160120
93	Protein digestion and absorption_Homo sapiens_hsa04974	0.28026844
94	One carbon pool by folate_Homo sapiens_hsa00670	0.27281043
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.26720063
96	Pancreatic secretion_Homo sapiens_hsa04972	0.26140051
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.25865294
98	p53 signaling pathway_Homo sapiens_hsa04115	0.25705932
99	PPAR signaling pathway_Homo sapiens_hsa03320	0.25532374
100	Ether lipid metabolism_Homo sapiens_hsa00565	0.23098896

TRIM53CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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