TRIM55

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.72441354
2actin-myosin filament sliding (GO:0033275)9.22237096
3muscle filament sliding (GO:0030049)9.22237096
4sarcomere organization (GO:0045214)9.02047862
5myofibril assembly (GO:0030239)8.46281570
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.12209480
7actin-mediated cell contraction (GO:0070252)7.77154240
8cardiac muscle contraction (GO:0060048)7.38513555
9negative regulation of potassium ion transmembrane transport (GO:1901380)7.25033385
10cardiac muscle cell development (GO:0055013)7.09396872
11cardiac muscle tissue morphogenesis (GO:0055008)6.95843087
12cardiac cell development (GO:0055006)6.68090261
13cardiac muscle hypertrophy (GO:0003300)6.56614698
14heart process (GO:0003015)6.44353174
15heart contraction (GO:0060047)6.44353174
16ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.42450849
17actomyosin structure organization (GO:0031032)6.27394779
18muscle tissue morphogenesis (GO:0060415)6.25626448
19striated muscle hypertrophy (GO:0014897)6.21671686
20regulation of sarcomere organization (GO:0060297)6.19352750
21negative regulation of cardiac muscle cell apoptotic process (GO:0010667)6.14029633
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.08333088
23adult heart development (GO:0007512)6.03629703
24striated muscle contraction (GO:0006941)5.96702429
25regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.96340485
26regulation of relaxation of muscle (GO:1901077)5.89874808
27tricarboxylic acid cycle (GO:0006099)5.84667226
28actin filament-based movement (GO:0030048)5.79619687
29regulation of actin filament-based movement (GO:1903115)5.64789662
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.61802558
31regulation of skeletal muscle contraction (GO:0014819)5.57086309
32muscle hypertrophy (GO:0014896)5.52765282
33muscle cell fate commitment (GO:0042693)5.43819986
34ventricular cardiac muscle cell action potential (GO:0086005)5.42025924
35negative regulation of striated muscle cell apoptotic process (GO:0010664)5.40006004
36heart trabecula formation (GO:0060347)5.35021674
37regulation of the force of heart contraction (GO:0002026)5.22126070
38regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.21607494
39regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.18480370
40muscle cell cellular homeostasis (GO:0046716)5.16827765
41regulation of cardioblast differentiation (GO:0051890)5.11457973
42regulation of striated muscle contraction (GO:0006942)5.09647302
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.05047598
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.01652783
45bundle of His cell to Purkinje myocyte communication (GO:0086069)4.97605300
46plasma membrane repair (GO:0001778)4.79012073
47cardiac muscle adaptation (GO:0014887)4.65817625
48cardiac muscle hypertrophy in response to stress (GO:0014898)4.65817625
49muscle hypertrophy in response to stress (GO:0003299)4.65817625
50ATP synthesis coupled proton transport (GO:0015986)4.64116481
51energy coupled proton transport, down electrochemical gradient (GO:0015985)4.64116481
52response to muscle activity (GO:0014850)4.62415947
53striated muscle atrophy (GO:0014891)4.57579550
54ventricular cardiac muscle cell development (GO:0055015)4.56596758
55sarcoplasmic reticulum calcium ion transport (GO:0070296)4.50077573
56carnitine shuttle (GO:0006853)4.49052496
57regulation of cell communication by electrical coupling (GO:0010649)4.48591124
58regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.48365327
59regulation of membrane repolarization (GO:0060306)4.44891434
60regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.41918696
61oxidative phosphorylation (GO:0006119)4.37176407
62cell communication by electrical coupling (GO:0010644)4.36480376
63skeletal muscle tissue regeneration (GO:0043403)4.36398490
64cell communication involved in cardiac conduction (GO:0086065)4.34544503
65response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.26930622
66negative regulation of protein localization to cell surface (GO:2000009)4.24540663
67skeletal muscle fiber development (GO:0048741)4.21443026
68striated muscle cell development (GO:0055002)4.19597401
69regulation of striated muscle cell apoptotic process (GO:0010662)4.18540263
70cardiac chamber formation (GO:0003207)4.13572745
71muscle atrophy (GO:0014889)4.11860655
72regulation of acyl-CoA biosynthetic process (GO:0050812)4.05590186
73myotube cell development (GO:0014904)4.02491688
74atrial septum morphogenesis (GO:0060413)4.00133979
75muscle fiber development (GO:0048747)3.97858166
76cardiac muscle cell action potential involved in contraction (GO:0086002)3.95190729
77regulation of ATPase activity (GO:0043462)3.94530327
78regulation of ATP catabolic process (GO:1903289)3.94530327
79regulation of heart rate (GO:0002027)3.93558097
80cardiac muscle cell action potential (GO:0086001)3.90090488
81skeletal muscle tissue development (GO:0007519)3.85668620
82response to inactivity (GO:0014854)3.85375708
83fatty acid transmembrane transport (GO:1902001)3.83966198
84regulation of cardiac muscle cell apoptotic process (GO:0010665)3.83039392
85regulation of cardiac muscle contraction (GO:0055117)3.82711231
86outflow tract septum morphogenesis (GO:0003148)3.81751091
87regulation of coenzyme metabolic process (GO:0051196)3.81580598
88regulation of cofactor metabolic process (GO:0051193)3.81580598
89respiratory electron transport chain (GO:0022904)3.76972577
90electron transport chain (GO:0022900)3.67396332
91negative regulation of potassium ion transport (GO:0043267)3.67340977
92positive regulation of myoblast differentiation (GO:0045663)3.65385463
93muscle contraction (GO:0006936)3.62300014
94muscle cell development (GO:0055001)3.62004098
95striated muscle adaptation (GO:0014888)3.61238386
96relaxation of cardiac muscle (GO:0055119)3.60002347
97regulation of muscle contraction (GO:0006937)3.58628178
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.58625128
99cardiac right ventricle morphogenesis (GO:0003215)3.56701690
100trabecula formation (GO:0060343)3.54260188
101regulation of heart contraction (GO:0008016)3.52224321
102cardiac conduction (GO:0061337)3.50368466
103skeletal muscle contraction (GO:0003009)3.46260428
104positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.45326392
105skeletal muscle adaptation (GO:0043501)3.42706009
106muscle system process (GO:0003012)3.42069422
107regulation of heart rate by cardiac conduction (GO:0086091)3.40315253
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38522457
109regulation of cardiac muscle cell contraction (GO:0086004)3.34811084
110regulation of muscle system process (GO:0090257)3.33965261
111positive regulation of cardiac muscle cell proliferation (GO:0060045)3.32329187
112positive regulation of cardiac muscle tissue development (GO:0055025)3.28129305
113negative regulation of myotube differentiation (GO:0010832)3.27158682
114muscle organ development (GO:0007517)3.24696211
115myoblast fusion (GO:0007520)3.24497509
116positive regulation of cardiac muscle tissue growth (GO:0055023)3.23784433
117production of molecular mediator involved in inflammatory response (GO:0002532)3.23644325
118muscle structure development (GO:0061061)3.22353576
119negative regulation of nitric-oxide synthase activity (GO:0051001)3.21942485
120cardiac ventricle formation (GO:0003211)3.19958047
121striated muscle tissue development (GO:0014706)3.18288180
122cell migration involved in heart development (GO:0060973)3.17281443
123regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.06719921
124regulation of secondary heart field cardioblast proliferation (GO:0003266)3.00090770
125regulation of cardioblast proliferation (GO:0003264)3.00090770
126muscle adaptation (GO:0043500)2.98982089
127musculoskeletal movement (GO:0050881)2.98136964
128multicellular organismal movement (GO:0050879)2.98136964
129negative regulation of muscle hypertrophy (GO:0014741)2.96587482
130membrane raft organization (GO:0031579)2.95927001
131regulation of myoblast differentiation (GO:0045661)2.93504208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse7.00159931
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.31006457
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.15731972
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.75944734
5* MEF2A_21415370_ChIP-Seq_HL-1_Mouse4.58897964
6TBX20_22328084_ChIP-Seq_HEART_Mouse4.52195977
7TBX20_22080862_ChIP-Seq_HEART_Mouse4.52195977
8BP1_19119308_ChIP-ChIP_Hs578T_Human4.48650180
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.04215967
10* GATA4_21415370_ChIP-Seq_HL-1_Mouse3.42980221
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.30316707
12* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse3.14053852
13* ESR1_20079471_ChIP-ChIP_T-47D_Human2.81591379
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.45611913
15* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.40369337
16ISL1_27105846_Chip-Seq_CPCs_Mouse2.36061433
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.27731180
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27187431
19GATA1_22025678_ChIP-Seq_K562_Human2.26903708
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.25144352
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.22643172
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.17506894
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.03167845
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99332114
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.97971748
26GBX2_23144817_ChIP-Seq_PC3_Human1.93308815
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93059922
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92080621
29ZNF263_19887448_ChIP-Seq_K562_Human1.89073618
30VDR_22108803_ChIP-Seq_LS180_Human1.86939775
31PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.86632297
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.85366091
33* TP53_18474530_ChIP-ChIP_U2OS_Human1.78700513
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68669218
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63608837
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63462446
37SMAD4_21799915_ChIP-Seq_A2780_Human1.63441372
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62860889
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61108062
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61108062
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60654268
42CLOCK_20551151_ChIP-Seq_293T_Human1.57585529
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55959830
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55743442
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54202744
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.49267279
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47737901
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44278870
49BRD4_25478319_ChIP-Seq_HGPS_Human1.42085240
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.41235582
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.40595468
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.40047909
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40010497
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37749342
55* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37256171
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.36461086
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35507143
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32875804
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.32137601
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.30373656
61TP53_16413492_ChIP-PET_HCT116_Human1.29192055
62* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28534247
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27600204
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25937912
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23828626
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22673112
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21814702
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.20765780
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.20110375
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19976774
71* SRF_21415370_ChIP-Seq_HL-1_Mouse1.19859063
72* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19647993
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18909162
74SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17415548
75P300_19829295_ChIP-Seq_ESCs_Human1.15372160
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15239151
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15025166
78P53_22387025_ChIP-Seq_ESCs_Mouse1.13968114
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11888179
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11485655
81ZNF274_21170338_ChIP-Seq_K562_Hela1.11384509
82CDX2_22108803_ChIP-Seq_LS180_Human1.10507074
83SOX2_18555785_Chip-Seq_ESCs_Mouse1.07623147
84* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07553730
85STAT3_23295773_ChIP-Seq_U87_Human1.05523272
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05439228
87* E2F1_18555785_Chip-Seq_ESCs_Mouse1.05003294
88TBL1_22424771_ChIP-Seq_293T_Human1.04622965
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04144021
90AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03312154
91PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02732414
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02396893
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02036121
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01807766
95TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00670454
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99208546
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98997114
98TP63_23658742_ChIP-Seq_EP156T_Human0.98838368
99ZFX_18555785_Chip-Seq_ESCs_Mouse0.98365129
100* CJUN_26792858_Chip-Seq_BT549_Human0.97357367
101PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97210720
102NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96961633
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96820886
104OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96656383
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96335797
106GATA1_19941826_ChIP-Seq_K562_Human0.95491617
107SOX2_19829295_ChIP-Seq_ESCs_Human0.95319470
108NANOG_19829295_ChIP-Seq_ESCs_Human0.95319470
109SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95311540
110CBP_20019798_ChIP-Seq_JUKART_Human0.95175750
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95175750
112ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94264469
113* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93718091
114* STAT3_18555785_Chip-Seq_ESCs_Mouse0.93429739
115EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92821613
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91990294
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89900261
118BCAT_22108803_ChIP-Seq_LS180_Human0.89561706
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89553869
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86401121
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.85596321
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84847127
123* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80912575
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.78891629
125SPI1_20517297_ChIP-Seq_HL60_Human0.78650164
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76922126
127SMC3_22415368_ChIP-Seq_MEFs_Mouse0.75789601
128WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75639171
129SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75050657
130RBPJ_22232070_ChIP-Seq_NCS_Mouse0.74350430
131MYC_19829295_ChIP-Seq_ESCs_Human0.74087621
132CTCF_27219007_Chip-Seq_Bcells_Human0.73823645
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.73215879
134TP63_22573176_ChIP-Seq_HFKS_Human0.73147630
135* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.72953169
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71366857
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.70307651
138GATA2_21666600_ChIP-Seq_HMVEC_Human0.70302248
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.69962036
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68155199
141STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.67573034
142TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67270125
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.66941526
144NANOG_21062744_ChIP-ChIP_HESCs_Human0.65740438
145OCT4_20526341_ChIP-Seq_ESCs_Human0.64984246
146LXR_22158963_ChIP-Seq_LIVER_Mouse0.64943756
147* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64210038
148SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.63974365
149FOXH1_21741376_ChIP-Seq_ESCs_Human0.63915202
150EZH2_27304074_Chip-Seq_ESCs_Mouse0.63359791
151RACK7_27058665_Chip-Seq_MCF-7_Human0.62386790
152TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.60317600
153UBF1/2_26484160_Chip-Seq_HMECs_Human0.60163972
154GF1_26923725_Chip-Seq_HPCs_Mouse0.60019157
155TP53_23651856_ChIP-Seq_MEFs_Mouse0.59797039
156* ATF3_27146783_Chip-Seq_COLON_Human0.59705278
157RUNX1_27514584_Chip-Seq_MCF-7_Human0.59340995
158AR_19668381_ChIP-Seq_PC3_Human0.59222081
159YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.59157142
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.58721703
161TDRD3_21172665_ChIP-Seq_MCF-7_Human0.58378516
162WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.57648620
163GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57527118
164ESR1_21235772_ChIP-Seq_MCF-7_Human0.56832690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.66855736
2MP0002837_dystrophic_cardiac_calcinosis5.11867005
3MP0004036_abnormal_muscle_relaxation4.84738048
4MP0000749_muscle_degeneration4.70291429
5MP0004215_abnormal_myocardial_fiber4.53734207
6MP0000751_myopathy4.32578331
7MP0005330_cardiomyopathy4.11555867
8MP0003646_muscle_fatigue3.80253102
9* MP0002972_abnormal_cardiac_muscle3.45059054
10MP0008775_abnormal_heart_ventricle3.29411548
11* MP0004087_abnormal_muscle_fiber3.16121560
12MP0004145_abnormal_muscle_electrophysio3.12641600
13MP0003137_abnormal_impulse_conducting3.02604713
14* MP0005620_abnormal_muscle_contractility2.93335200
15* MP0010630_abnormal_cardiac_muscle2.81674712
16MP0002106_abnormal_muscle_physiology2.70547196
17MP0001544_abnormal_cardiovascular_syste2.69309428
18MP0005385_cardiovascular_system_phenoty2.69309428
19MP0006138_congestive_heart_failure2.60648086
20MP0000750_abnormal_muscle_regeneration2.57813522
21MP0004510_myositis2.46731437
22MP0003221_abnormal_cardiomyocyte_apopto2.39921931
23MP0004085_abnormal_heartbeat2.34915053
24MP0002269_muscular_atrophy2.32711122
25MP0004484_altered_response_of2.22716480
26MP0002127_abnormal_cardiovascular_syste2.20027100
27MP0005369_muscle_phenotype2.14185644
28MP0003567_abnormal_fetal_cardiomyocyte2.14178998
29MP0003950_abnormal_plasma_membrane2.10046806
30MP0000747_muscle_weakness2.06565351
31MP0003195_calcinosis1.94565591
32MP0004233_abnormal_muscle_weight1.89311787
33* MP0000759_abnormal_skeletal_muscle1.84544969
34MP0004130_abnormal_muscle_cell1.82304281
35MP0005451_abnormal_body_composition1.77106453
36MP0005360_urolithiasis1.74057661
37MP0004270_analgesia1.69535980
38MP0006036_abnormal_mitochondrial_physio1.63750522
39* MP0003828_pulmonary_edema1.62388162
40MP0003122_maternal_imprinting1.61949289
41MP0009780_abnormal_chondrocyte_physiolo1.46285422
42MP0002139_abnormal_hepatobiliary_system1.30058933
43* MP0000266_abnormal_heart_morphology1.29338728
44MP0002332_abnormal_exercise_endurance1.24819041
45MP0001661_extended_life_span1.19255951
46MP0004272_abnormal_basement_membrane1.14011554
47MP0003279_aneurysm1.13033643
48MP0003123_paternal_imprinting1.08537742
49MP0006035_abnormal_mitochondrial_morpho1.07268969
50MP0001299_abnormal_eye_distance/1.04857418
51MP0003566_abnormal_cell_adhesion1.03319424
52MP0009384_cardiac_valve_regurgitation1.00451088
53MP0002234_abnormal_pharynx_morphology0.97655176
54MP0010030_abnormal_orbit_morphology0.94678022
55MP0005332_abnormal_amino_acid0.94262559
56MP0010368_abnormal_lymphatic_system0.94026640
57MP0000733_abnormal_muscle_development0.93233300
58MP0003121_genomic_imprinting0.88284555
59MP0004883_abnormal_blood_vessel0.83064846
60MP0000343_altered_response_to0.82443566
61MP0002088_abnormal_embryonic_growth/wei0.80266505
62* MP0002128_abnormal_blood_circulation0.79919120
63MP0003984_embryonic_growth_retardation0.79092187
64MP0002102_abnormal_ear_morphology0.78378572
65MP0005165_increased_susceptibility_to0.78114553
66MP0003878_abnormal_ear_physiology0.78051466
67MP0005377_hearing/vestibular/ear_phenot0.78051466
68MP0000003_abnormal_adipose_tissue0.77874108
69MP0008789_abnormal_olfactory_epithelium0.77058194
70MP0005623_abnormal_meninges_morphology0.75386340
71MP0003806_abnormal_nucleotide_metabolis0.73404883
72MP0002925_abnormal_cardiovascular_devel0.71517114
73MP0000230_abnormal_systemic_arterial0.71006339
74MP0000767_abnormal_smooth_muscle0.70646563
75MP0005266_abnormal_metabolism0.69789846
76MP0000372_irregular_coat_pigmentation0.68446630
77MP0003252_abnormal_bile_duct0.68215788
78MP0002108_abnormal_muscle_morphology0.67406947
79MP0009250_abnormal_appendicular_skeleto0.67098048
80MP0005666_abnormal_adipose_tissue0.66098068
81MP0001529_abnormal_vocalization0.58808294
82MP0005023_abnormal_wound_healing0.57737660
83MP0001879_abnormal_lymphatic_vessel0.56949823
84MP0003045_fibrosis0.56521336
85* MP0001784_abnormal_fluid_regulation0.56246929
86MP0002168_other_aberrant_phenotype0.56045616
87MP0003941_abnormal_skin_development0.55631809
88MP0005164_abnormal_response_to0.55173132
89MP0003705_abnormal_hypodermis_morpholog0.54139794
90MP0001958_emphysema0.53958410
91MP0001672_abnormal_embryogenesis/_devel0.53857527
92MP0005380_embryogenesis_phenotype0.53857527
93MP0005085_abnormal_gallbladder_physiolo0.53739594
94MP0002896_abnormal_bone_mineralization0.51830919
95MP0008875_abnormal_xenobiotic_pharmacok0.51340997
96MP0001614_abnormal_blood_vessel0.50574027
97MP0003091_abnormal_cell_migration0.50439754
98MP0003385_abnormal_body_wall0.50334125
99MP0005670_abnormal_white_adipose0.49886598
100MP0001542_abnormal_bone_strength0.45818387
101MP0002233_abnormal_nose_morphology0.45788716
102MP0001849_ear_inflammation0.44209200
103MP0003191_abnormal_cellular_cholesterol0.44077944
104MP0005408_hypopigmentation0.43960957
105MP0002933_joint_inflammation0.41740380
106MP0002295_abnormal_pulmonary_circulatio0.41187378
107MP0001730_embryonic_growth_arrest0.40873744
108MP0003948_abnormal_gas_homeostasis0.40111395
109MP0004134_abnormal_chest_morphology0.39875086
110MP0009672_abnormal_birth_weight0.39014190
111MP0003115_abnormal_respiratory_system0.38986347
112MP0008438_abnormal_cutaneous_collagen0.37711584
113MP0005375_adipose_tissue_phenotype0.36833415
114MP0001697_abnormal_embryo_size0.34213409
115MP0005376_homeostasis/metabolism_phenot0.34156359
116MP0009697_abnormal_copulation0.32891730
117MP0004197_abnormal_fetal_growth/weight/0.32645113
118MP0002086_abnormal_extraembryonic_tissu0.32324438
119MP0005595_abnormal_vascular_smooth0.32092801
120MP0004185_abnormal_adipocyte_glucose0.30444575
121MP0002971_abnormal_brown_adipose0.29455186
122MP0003935_abnormal_craniofacial_develop0.28228827
123MP0005319_abnormal_enzyme/_coenzyme0.27883770
124MP0000428_abnormal_craniofacial_morphol0.27147123
125MP0000762_abnormal_tongue_morphology0.25586055
126MP0000013_abnormal_adipose_tissue0.24829266
127MP0001727_abnormal_embryo_implantation0.24333221
128MP0004043_abnormal_pH_regulation0.24082406
129MP0005275_abnormal_skin_tensile0.23856053
130MP0005503_abnormal_tendon_morphology0.23652321
131MP0005187_abnormal_penis_morphology0.22394624
132MP0002080_prenatal_lethality0.21975275
133MP0001485_abnormal_pinna_reflex0.21624344
134* MP0001175_abnormal_lung_morphology0.21442685
135MP0002078_abnormal_glucose_homeostasis0.18307998

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.45316812
2Popliteal pterygium (HP:0009756)7.47655619
3Exercise-induced muscle cramps (HP:0003710)6.72972256
4Type 2 muscle fiber atrophy (HP:0003554)6.57910136
5Ventricular tachycardia (HP:0004756)6.45585297
6Calf muscle hypertrophy (HP:0008981)6.42929975
7Subaortic stenosis (HP:0001682)6.15382060
8Abnormality of the left ventricular outflow tract (HP:0011103)6.15382060
9Atrial fibrillation (HP:0005110)6.02920811
10Exercise-induced myalgia (HP:0003738)5.98559458
11Muscle hypertrophy of the lower extremities (HP:0008968)5.91718157
12Muscle fiber atrophy (HP:0100295)5.83519979
13Primary atrial arrhythmia (HP:0001692)5.61628141
14Lipoatrophy (HP:0100578)5.51506041
15Supraventricular tachycardia (HP:0004755)5.44305889
16Abnormality of the calf musculature (HP:0001430)5.43572906
17Abnormality of placental membranes (HP:0011409)5.41088413
18Amniotic constriction ring (HP:0009775)5.41088413
19Abnormality of the neuromuscular junction (HP:0003398)5.35715178
20Fatigable weakness (HP:0003473)5.35715178
21Supraventricular arrhythmia (HP:0005115)5.33619532
22Weak cry (HP:0001612)5.00424687
23Syncope (HP:0001279)4.93138622
24Fetal akinesia sequence (HP:0001989)4.90299214
25Muscle fiber splitting (HP:0003555)4.77164780
26Right ventricular cardiomyopathy (HP:0011663)4.68969566
27Hyporeflexia of lower limbs (HP:0002600)4.68242527
28Aplasia of the musculature (HP:0100854)4.59821091
29Myoglobinuria (HP:0002913)4.58798542
30Ventricular arrhythmia (HP:0004308)4.54686020
31Prolonged QT interval (HP:0001657)4.49256698
32Dilated cardiomyopathy (HP:0001644)4.43100847
33EMG: myopathic abnormalities (HP:0003458)4.37442576
34Malignant hyperthermia (HP:0002047)4.14405632
35Palpitations (HP:0001962)4.12803364
36Type 1 muscle fiber predominance (HP:0003803)4.00196431
37Asymmetric septal hypertrophy (HP:0001670)3.98827633
38Rhabdomyolysis (HP:0003201)3.74660190
39Ulnar deviation of the wrist (HP:0003049)3.74425967
40Ventricular fibrillation (HP:0001663)3.69372800
41Easy fatigability (HP:0003388)3.68333290
42Pterygium (HP:0001059)3.54094446
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.44480898
44Bundle branch block (HP:0011710)3.38781333
45Centrally nucleated skeletal muscle fibers (HP:0003687)3.37063275
46Muscle fiber inclusion bodies (HP:0100299)3.33174484
47Absent phalangeal crease (HP:0006109)3.28685003
48Abnormal EKG (HP:0003115)3.27984538
49Thin ribs (HP:0000883)3.19883989
50Ragged-red muscle fibers (HP:0003200)3.17829979
51Heart block (HP:0012722)3.17449317
52Atrioventricular block (HP:0001678)3.17337876
53Left ventricular hypertrophy (HP:0001712)3.07843171
54Neck muscle weakness (HP:0000467)2.98075466
55Abnormal atrioventricular conduction (HP:0005150)2.97582307
56Double outlet right ventricle (HP:0001719)2.96512253
57Congenital malformation of the right heart (HP:0011723)2.96512253
58Nemaline bodies (HP:0003798)2.95900351
59Increased connective tissue (HP:0009025)2.90831759
60Myotonia (HP:0002486)2.85993424
61Akinesia (HP:0002304)2.85907076
62Abnormal mitochondria in muscle tissue (HP:0008316)2.81256277
63Nonprogressive disorder (HP:0003680)2.80951086
64Acute necrotizing encephalopathy (HP:0006965)2.78668361
65Difficulty running (HP:0009046)2.73268887
66Abnormal finger flexion creases (HP:0006143)2.69803405
67Palmoplantar keratoderma (HP:0000982)2.69691629
68Generalized muscle weakness (HP:0003324)2.61982118
69Respiratory insufficiency due to muscle weakness (HP:0002747)2.60662361
70Bulbar palsy (HP:0001283)2.59407070
71Hepatic necrosis (HP:0002605)2.56857127
72Calcaneovalgus deformity (HP:0001848)2.56310192
73Conjunctival hamartoma (HP:0100780)2.52824267
74Aplasia/Hypoplasia involving the musculature (HP:0001460)2.51776023
75Abnormality of glycolysis (HP:0004366)2.48726700
76Increased serum pyruvate (HP:0003542)2.48726700
77Patent foramen ovale (HP:0001655)2.48187683
78Muscle stiffness (HP:0003552)2.44974178
79Decreased muscle mass (HP:0003199)2.44791144
80Distal lower limb muscle weakness (HP:0009053)2.43374633
81EMG: neuropathic changes (HP:0003445)2.42959273
82Mildly elevated creatine phosphokinase (HP:0008180)2.41472358
83Hypoplastic heart (HP:0001961)2.39750073
84Hypoplastic left heart (HP:0004383)2.38769351
85Rimmed vacuoles (HP:0003805)2.34718435
86Exercise intolerance (HP:0003546)2.34467963
87Neoplasm of the adrenal gland (HP:0100631)2.33297391
88Pheochromocytoma (HP:0002666)2.26790836
89Acute encephalopathy (HP:0006846)2.26044976
90Increased CSF lactate (HP:0002490)2.25864875
91Progressive macrocephaly (HP:0004481)2.25560599
92Deformed tarsal bones (HP:0008119)2.25467525
93Difficulty climbing stairs (HP:0003551)2.25101402
94Hypoglycemic coma (HP:0001325)2.24951014
95Mitochondrial inheritance (HP:0001427)2.23756051
96Cystic hygroma (HP:0000476)2.20509324
97Myopathic facies (HP:0002058)2.20395751
98Areflexia of lower limbs (HP:0002522)2.19468045
99Abnormality of the foot musculature (HP:0001436)2.15600937
100Hepatocellular necrosis (HP:0001404)2.14761432
101Sudden cardiac death (HP:0001645)2.11485159
102Limb-girdle muscle atrophy (HP:0003797)2.07784147
103Neuroendocrine neoplasm (HP:0100634)2.05732778
104Depressed nasal tip (HP:0000437)1.99940189
105Aortic aneurysm (HP:0004942)1.99114643
106Distal arthrogryposis (HP:0005684)1.98431049
107Congestive heart failure (HP:0001635)1.97506865
108Abnormalities of placenta or umbilical cord (HP:0001194)1.95138845
109Long clavicles (HP:0000890)1.95080096
110Gowers sign (HP:0003391)1.94921844
111Cerebral edema (HP:0002181)1.94284062
112Ketoacidosis (HP:0001993)1.91807504
113Abnormality of skeletal muscle fiber size (HP:0012084)1.90682659
114Increased variability in muscle fiber diameter (HP:0003557)1.90090379
115Diaphragmatic weakness (HP:0009113)1.89522887
116Scapular winging (HP:0003691)1.87709115
117Periauricular skin pits (HP:0100277)1.86011449
118Preauricular pit (HP:0004467)1.86011449
119Round ear (HP:0100830)1.84953314
120Arterial tortuosity (HP:0005116)1.82345618
121Infantile muscular hypotonia (HP:0008947)1.80846484
122Dicarboxylic aciduria (HP:0003215)1.80237090
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80237090
124Lactic acidosis (HP:0003128)1.79792260
125Steppage gait (HP:0003376)1.79073783
126Abnormality of the ischium (HP:0003174)1.78543957
127Hypoplastic ischia (HP:0003175)1.77533354
128Cholecystitis (HP:0001082)1.77445762
129Abnormal gallbladder physiology (HP:0012438)1.77445762
130Hamartoma of the eye (HP:0010568)1.75275458
131Foot dorsiflexor weakness (HP:0009027)1.74834529
132Increased muscle lipid content (HP:0009058)1.74522244
133Respiratory failure (HP:0002878)1.73342101
134Hip contracture (HP:0003273)1.70473788
135Limited hip movement (HP:0008800)1.70242060
136Proximal tubulopathy (HP:0000114)1.68568711
137Muscular dystrophy (HP:0003560)1.68041482
138Abnormality of fatty-acid metabolism (HP:0004359)1.67483210
139Poor suck (HP:0002033)1.67158412
140Bradycardia (HP:0001662)1.66819185
141Abnormality of the tricuspid valve (HP:0001702)1.66782649
142Diminished movement (HP:0002374)1.66706619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.04274395
2MYLK4.60087637
3STK244.42687723
4PKN23.82460686
5TTN3.30570803
6DMPK2.84333715
7PHKG22.73309006
8PHKG12.73309006
9PDK32.65477029
10PDK42.65477029
11NEK12.64091866
12ZAK2.62699251
13PIK3CA2.59993169
14MAP3K122.27278144
15LMTK22.22564603
16TRIB32.12690101
17MUSK2.09281327
18ILK2.06130173
19CCNB11.87471611
20STK38L1.84792236
21TIE11.73775785
22CDC42BPA1.71078062
23PDK21.45746066
24BCKDK1.43040650
25LIMK11.42781443
26TRPM71.40167713
27VRK21.29087564
28FLT31.27594684
29ROCK11.09325694
30DAPK31.07747843
31PAK31.02618383
32WNK40.99938281
33CAMK2D0.99724646
34MAP3K70.99595076
35STK40.96398950
36MAPK120.93802650
37FRK0.91995866
38CDK80.91854344
39PRKD10.88670323
40PTK2B0.79294786
41PINK10.79264741
42MAP3K50.79153766
43MAP2K30.77041112
44MAP3K100.76480093
45INSRR0.75802423
46PAK40.74669726
47STK390.72290590
48TESK10.69633070
49PRKAA20.69478999
50GRK70.67506773
51OXSR10.66726123
52PRKAA10.66636443
53PTK20.66548282
54IRAK30.65975815
55MELK0.65013662
56PRKD30.64463966
57CAMK10.64293757
58MAP3K30.64168127
59TNIK0.62752259
60PLK20.62531743
61PIK3CG0.60691447
62MET0.58809456
63WNK10.57413099
64STK30.54517311
65ERBB30.52730801
66SIK30.51795310
67KDR0.51437548
68BCR0.50368217
69BMPR1B0.50189093
70MARK10.50107415
71MAP3K90.49574274
72CAMK2A0.49430856
73KSR10.48057473
74FER0.47925437
75ROCK20.47799237
76ARAF0.47291548
77CAMK40.46806616
78RIPK10.45739298
79PRKACB0.45480169
80AKT20.45411253
81CAMK2B0.41335852
82FGFR10.40825987
83PKN10.40298959
84MARK30.40189699
85PAK20.39365323
86NEK90.37400065
87NME10.36982583
88KSR20.35902428
89MAPKAPK30.35543953
90DDR20.35522247
91STK380.34680346
92PRKACA0.33981506
93RPS6KL10.33045026
94RPS6KC10.33045026
95TRIM280.32646163
96BRSK20.31927368
97PRKG10.31594868
98PDGFRA0.30434726
99MST40.30335667
100MAPKAPK50.29703222
101MST1R0.29012783
102EIF2AK30.28590317
103EPHB20.27949100
104CASK0.27672080
105PTK60.25456803
106PAK60.25019028
107UHMK10.24912191
108RPS6KA60.24315693
109LATS10.24069712
110PRKG20.23985721
111CAMK2G0.23801967
112PRKACG0.23226570
113PRKCE0.22926668
114ACVR1B0.22672359
115CDK40.22631538
116PRKCQ0.22551642
117RAF10.22097692
118ERBB40.21547369
119EEF2K0.21024107
120LATS20.19827663
121MOS0.18313168
122NUAK10.17705959
123MAPK40.17197391
124ICK0.16272449
125RPS6KB10.15075672
126TGFBR20.14711851
127LRRK20.14292632
128MAPK70.14227249
129ADRBK10.13030769
130PDK10.12794218
131AKT10.10253073
132MAPKAPK20.10140901
133MTOR0.09479555
134AURKB0.09281387
135RPS6KA10.09098244
136RPS6KA30.08395370
137MAP2K10.07943709
138EGFR0.07396996
139MAP2K40.06601562

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.06293149
2Cardiac muscle contraction_Homo sapiens_hsa042605.39567022
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.42865815
4Dilated cardiomyopathy_Homo sapiens_hsa054144.29403631
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.96973830
6Parkinsons disease_Homo sapiens_hsa050123.49851413
7Oxidative phosphorylation_Homo sapiens_hsa001903.25213148
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.73853383
9Carbon metabolism_Homo sapiens_hsa012002.55730892
10Propanoate metabolism_Homo sapiens_hsa006402.52341912
11Alzheimers disease_Homo sapiens_hsa050102.43744272
12Huntingtons disease_Homo sapiens_hsa050162.28043511
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.25486490
14Sulfur metabolism_Homo sapiens_hsa009202.17650557
15Fatty acid degradation_Homo sapiens_hsa000712.17423961
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13049753
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03901315
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.85390570
19Pyruvate metabolism_Homo sapiens_hsa006201.69147984
20Fatty acid metabolism_Homo sapiens_hsa012121.65256917
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.64077914
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56261944
23Biosynthesis of amino acids_Homo sapiens_hsa012301.51750186
24Viral myocarditis_Homo sapiens_hsa054161.47324050
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45904036
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31991637
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28609751
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28104900
29Complement and coagulation cascades_Homo sapiens_hsa046101.27245791
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25622465
31Glucagon signaling pathway_Homo sapiens_hsa049221.23274268
32Retinol metabolism_Homo sapiens_hsa008301.16490276
33Fatty acid elongation_Homo sapiens_hsa000621.10017239
34Tight junction_Homo sapiens_hsa045301.08758591
35Caffeine metabolism_Homo sapiens_hsa002321.07130197
36Starch and sucrose metabolism_Homo sapiens_hsa005001.07104176
37HIF-1 signaling pathway_Homo sapiens_hsa040661.05203959
38Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97033260
39Galactose metabolism_Homo sapiens_hsa000520.97023421
40Insulin resistance_Homo sapiens_hsa049310.96882929
41Focal adhesion_Homo sapiens_hsa045100.92057351
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89184934
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.88017373
44Insulin signaling pathway_Homo sapiens_hsa049100.83824256
45Oxytocin signaling pathway_Homo sapiens_hsa049210.80562228
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80268408
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77191317
48Fructose and mannose metabolism_Homo sapiens_hsa000510.77104753
49Bile secretion_Homo sapiens_hsa049760.77072935
50Chemical carcinogenesis_Homo sapiens_hsa052040.77019138
51Nitrogen metabolism_Homo sapiens_hsa009100.76538966
52Butanoate metabolism_Homo sapiens_hsa006500.73548605
53Calcium signaling pathway_Homo sapiens_hsa040200.73343878
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.73119378
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72360949
56Histidine metabolism_Homo sapiens_hsa003400.71482422
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70833918
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.68620158
59Adherens junction_Homo sapiens_hsa045200.66008983
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.65500052
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62495474
62AMPK signaling pathway_Homo sapiens_hsa041520.58013260
63Prion diseases_Homo sapiens_hsa050200.53798022
64PPAR signaling pathway_Homo sapiens_hsa033200.53730258
65Lysine degradation_Homo sapiens_hsa003100.53286412
66One carbon pool by folate_Homo sapiens_hsa006700.51815101
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51325826
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.50363728
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50012670
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47855986
71Phenylalanine metabolism_Homo sapiens_hsa003600.47573798
72Linoleic acid metabolism_Homo sapiens_hsa005910.46939844
73ECM-receptor interaction_Homo sapiens_hsa045120.46318261
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.44614431
75Protein digestion and absorption_Homo sapiens_hsa049740.43371809
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38627516
77GABAergic synapse_Homo sapiens_hsa047270.37855345
78Type II diabetes mellitus_Homo sapiens_hsa049300.37504850
79Proteoglycans in cancer_Homo sapiens_hsa052050.37105223
80beta-Alanine metabolism_Homo sapiens_hsa004100.36791384
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35966471
82Tryptophan metabolism_Homo sapiens_hsa003800.35870098
83Circadian rhythm_Homo sapiens_hsa047100.35237459
84Pancreatic secretion_Homo sapiens_hsa049720.34941841
85Amphetamine addiction_Homo sapiens_hsa050310.34332724
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32903891
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32564279
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.32140719
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31833713
90Melanoma_Homo sapiens_hsa052180.31144548
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29800547
92cAMP signaling pathway_Homo sapiens_hsa040240.29646315
93Circadian entrainment_Homo sapiens_hsa047130.28944515
94Mineral absorption_Homo sapiens_hsa049780.27702915
95Amoebiasis_Homo sapiens_hsa051460.27623678
96Renin secretion_Homo sapiens_hsa049240.27537683
97Arginine and proline metabolism_Homo sapiens_hsa003300.27440694
98Insulin secretion_Homo sapiens_hsa049110.25675676
99Hippo signaling pathway_Homo sapiens_hsa043900.25650580
100Metabolic pathways_Homo sapiens_hsa011000.24916757
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.24440514
102Tyrosine metabolism_Homo sapiens_hsa003500.21059214
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20000294
104Pentose phosphate pathway_Homo sapiens_hsa000300.18416463
105Gastric acid secretion_Homo sapiens_hsa049710.15242026
106Proteasome_Homo sapiens_hsa030500.14197659
107Peroxisome_Homo sapiens_hsa041460.14056810
108Arginine biosynthesis_Homo sapiens_hsa002200.13624311
109Olfactory transduction_Homo sapiens_hsa047400.13219933
110Oocyte meiosis_Homo sapiens_hsa041140.12941714
111mTOR signaling pathway_Homo sapiens_hsa041500.12930830
112RNA degradation_Homo sapiens_hsa030180.12685795
113FoxO signaling pathway_Homo sapiens_hsa040680.11940846
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.11411265
115Melanogenesis_Homo sapiens_hsa049160.10894685
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10847377
117Fatty acid biosynthesis_Homo sapiens_hsa000610.10276392
118Basal cell carcinoma_Homo sapiens_hsa052170.09902866
119Platelet activation_Homo sapiens_hsa046110.09646877
120Small cell lung cancer_Homo sapiens_hsa052220.08436787
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.06650135
122TGF-beta signaling pathway_Homo sapiens_hsa043500.06195519
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.03986131
124Ovarian steroidogenesis_Homo sapiens_hsa049130.03762490
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.03306089
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.02922581
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.02569497
128HTLV-I infection_Homo sapiens_hsa051660.02364280
129Renal cell carcinoma_Homo sapiens_hsa052110.00578721
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.00349344
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.00224079
132Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0066978
133GnRH signaling pathway_Homo sapiens_hsa04912-0.0001355

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