TRIM58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme metabolic process (GO:0042168)9.59307828
2hemoglobin metabolic process (GO:0020027)8.98793648
3response to methylmercury (GO:0051597)8.41721818
4erythrocyte development (GO:0048821)8.31575456
5response to insecticide (GO:0017085)7.02157366
6regulation of response to osmotic stress (GO:0047484)6.72318594
7response to lead ion (GO:0010288)6.69086501
8tetrapyrrole metabolic process (GO:0033013)6.50403478
9myeloid cell development (GO:0061515)5.88915819
10erythrocyte differentiation (GO:0030218)5.85291869
11positive regulation of gamma-delta T cell activation (GO:0046645)5.82875297
12pigment biosynthetic process (GO:0046148)5.70456558
13hepatocyte apoptotic process (GO:0097284)5.50530180
14regulation of B cell receptor signaling pathway (GO:0050855)5.41402156
15one-carbon compound transport (GO:0019755)5.37150627
16regulation of DNA endoreduplication (GO:0032875)5.32840048
17microglial cell activation (GO:0001774)5.17126894
18positive regulation of granulocyte differentiation (GO:0030854)5.08988101
19DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla5.03313909
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.77217452
21negative regulation of cell killing (GO:0031342)4.77217452
22negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.72296722
23DNA damage response, signal transduction resulting in transcription (GO:0042772)4.67804979
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.61494317
25pigment metabolic process (GO:0042440)4.59772991
26nucleosome assembly (GO:0006334)4.54781566
27oxygen transport (GO:0015671)4.53541696
28microtubule depolymerization (GO:0007019)4.51041404
29neutrophil activation involved in immune response (GO:0002283)4.50851445
30regulation of platelet aggregation (GO:0090330)4.47505537
31innate immune response in mucosa (GO:0002227)4.43567189
32embryonic hemopoiesis (GO:0035162)4.33411407
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25010846
34response to arsenic-containing substance (GO:0046685)4.24084678
35very-low-density lipoprotein particle assembly (GO:0034379)4.18642636
36antibacterial humoral response (GO:0019731)4.17729586
37regulation of gamma-delta T cell differentiation (GO:0045586)4.16306598
38mitotic sister chromatid segregation (GO:0000070)4.13620925
39positive regulation of DNA-dependent DNA replication (GO:2000105)4.11119176
40bicarbonate transport (GO:0015701)4.06637826
41regulation of gamma-delta T cell activation (GO:0046643)4.05057708
42negative regulation of viral entry into host cell (GO:0046597)4.04946339
43megakaryocyte development (GO:0035855)4.03101961
44kinetochore organization (GO:0051383)4.02186443
45nucleosome organization (GO:0034728)3.97534658
46protein-DNA complex assembly (GO:0065004)3.96017134
47platelet formation (GO:0030220)3.95056022
48definitive hemopoiesis (GO:0060216)3.94969724
49granulocyte differentiation (GO:0030851)3.91590279
50actin filament capping (GO:0051693)3.86792822
51antimicrobial humoral response (GO:0019730)3.86016599
52gas transport (GO:0015669)3.85417137
53positive T cell selection (GO:0043368)3.83213271
54positive regulation of erythrocyte differentiation (GO:0045648)3.81150742
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80327763
56positive regulation by organism of defense response of other organism involved in symbiotic interact3.80327763
57modulation by symbiont of host immune response (GO:0052553)3.80327763
58positive regulation by symbiont of host defense response (GO:0052509)3.80327763
59modulation by symbiont of host defense response (GO:0052031)3.80327763
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80327763
61negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.78376844
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.75041090
63regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.74801029
64sister chromatid segregation (GO:0000819)3.70798111
65positive thymic T cell selection (GO:0045059)3.70780835
66protein K11-linked deubiquitination (GO:0035871)3.67118119
67negative T cell selection (GO:0043383)3.65555489
68activated T cell proliferation (GO:0050798)3.62012278
69cellular extravasation (GO:0045123)3.58850965
70neutrophil mediated immunity (GO:0002446)3.58735431
71protein-DNA complex subunit organization (GO:0071824)3.57024507
72hepatocyte differentiation (GO:0070365)3.53188968
73regulation of erythrocyte differentiation (GO:0045646)3.53103227
74negative thymic T cell selection (GO:0045060)3.52091653
75regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.51244046
76kinetochore assembly (GO:0051382)3.46870255
77B cell receptor signaling pathway (GO:0050853)3.46170376
78macrophage activation (GO:0042116)3.45807069
79neutrophil activation (GO:0042119)3.44743043
80mucosal immune response (GO:0002385)3.43709683
81phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.43361908
82histone mRNA catabolic process (GO:0071044)3.43336514
83negative regulation of T cell mediated immunity (GO:0002710)3.43120919
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42985601
85iron ion import (GO:0097286)3.39200476
86positive regulation of mast cell activation (GO:0033005)3.37282738
87negative regulation of lymphocyte mediated immunity (GO:0002707)3.33066968
88protein localization to chromosome, centromeric region (GO:0071459)3.32751478
89positive regulation of B cell differentiation (GO:0045579)3.29613747
90myeloid leukocyte mediated immunity (GO:0002444)3.28988784
91regulation of granulocyte differentiation (GO:0030852)3.28282142
92positive regulation of receptor recycling (GO:0001921)3.27064751
93organ or tissue specific immune response (GO:0002251)3.26646821
94detection of molecule of bacterial origin (GO:0032490)3.21795578
95regulation of cytokine secretion involved in immune response (GO:0002739)3.21776710
96negative regulation of B cell proliferation (GO:0030889)3.21740065
97myeloid cell activation involved in immune response (GO:0002275)3.19703766
98thrombin receptor signaling pathway (GO:0070493)3.18669162
99regulation of inositol phosphate biosynthetic process (GO:0010919)3.17794263
100positive regulation of cellular response to oxidative stress (GO:1900409)3.15145281
101positive regulation of response to oxidative stress (GO:1902884)3.15145281
102chromatin assembly (GO:0031497)3.14164925
103regulation of B cell differentiation (GO:0045577)3.14161133
104DNA replication initiation (GO:0006270)3.13459657
105histone H3-K36 demethylation (GO:0070544)3.11890027
106negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.09707752
107granulocyte activation (GO:0036230)3.09047764
108dopamine transport (GO:0015872)3.08792246
109regulation of necroptotic process (GO:0060544)3.07779450
110mitotic chromosome condensation (GO:0007076)3.06368548
111positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.06257363
112regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.06257363
113regulation of mast cell activation (GO:0033003)3.05295945
114leukocyte migration involved in inflammatory response (GO:0002523)3.04963978
115cofactor biosynthetic process (GO:0051188)3.04269901
116macrophage activation involved in immune response (GO:0002281)3.04097487
117DNA strand renaturation (GO:0000733)3.03039502
118regulation of regulatory T cell differentiation (GO:0045589)3.02799137
119response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.02394172
120response to host immune response (GO:0052572)3.02394172
121meiotic chromosome segregation (GO:0045132)3.00562840
122L-alpha-amino acid transmembrane transport (GO:1902475)3.00454888
123attachment of spindle microtubules to kinetochore (GO:0008608)3.00264605
124leukocyte degranulation (GO:0043299)2.99422782
125microtubule polymerization or depolymerization (GO:0031109)2.98006763
126negative regulation of actin filament depolymerization (GO:0030835)2.96283767
127telomere maintenance via semi-conservative replication (GO:0032201)2.96188409
128positive regulation of mRNA catabolic process (GO:0061014)2.96046715
129regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.95370504
130positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.95370504
131DNA replication-dependent nucleosome assembly (GO:0006335)2.94615409
132DNA replication-dependent nucleosome organization (GO:0034723)2.94615409
133regulation of viral entry into host cell (GO:0046596)2.93680616
134positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.92543532
135negative regulation of execution phase of apoptosis (GO:1900118)2.92469710
136regulation of beta-amyloid formation (GO:1902003)2.92287868
137protein localization to kinetochore (GO:0034501)2.92187020
138regulation of platelet activation (GO:0010543)2.92159460
139cytoskeletal anchoring at plasma membrane (GO:0007016)2.91042956
140regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90839684
1413-UTR-mediated mRNA stabilization (GO:0070935)2.90313323
142negative regulation of interleukin-12 production (GO:0032695)2.88279061
143positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.86429183
144negative regulation of T-helper cell differentiation (GO:0045623)2.86323568
145negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.86323568
146negative regulation of neurotransmitter transport (GO:0051589)2.86184690
147T cell proliferation (GO:0042098)2.85697578
148negative regulation of adaptive immune response (GO:0002820)2.83466254
149chromatin assembly or disassembly (GO:0006333)2.83116690
150N-acetylneuraminate metabolic process (GO:0006054)2.81824117
151protein K48-linked deubiquitination (GO:0071108)2.81389414
152regulation of mitochondrial depolarization (GO:0051900)2.81051442
153negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.80381541
154regulation of mast cell degranulation (GO:0043304)2.80328051
155positive regulation of insulin receptor signaling pathway (GO:0046628)2.79624966
156mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.78850525
157positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.78850525
158response to xenobiotic stimulus (GO:0009410)2.77598983
159regulation of stem cell maintenance (GO:2000036)2.75657822
160negative regulation of leukocyte mediated immunity (GO:0002704)2.75273518
161import into cell (GO:0098657)2.74739071
162T cell selection (GO:0045058)2.74725011
163organelle membrane fusion (GO:0090174)2.71318526
164cellular response to dexamethasone stimulus (GO:0071549)2.66920225
165regulation of DNA-dependent DNA replication (GO:0090329)2.64598647
166DNA strand elongation (GO:0022616)2.64532525
167lipopolysaccharide biosynthetic process (GO:0009103)2.62587397
168DNA strand elongation involved in DNA replication (GO:0006271)2.59905927
169regulation of centriole replication (GO:0046599)2.56325170
170maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55336964
171plasma lipoprotein particle assembly (GO:0034377)2.51017539
172negative regulation of cell aging (GO:0090344)2.49083533
173positive regulation of fibroblast migration (GO:0010763)2.48837691
174regulation of mRNA catabolic process (GO:0061013)2.48318912
175replication fork processing (GO:0031297)2.46708411
176DNA unwinding involved in DNA replication (GO:0006268)2.46675342
177response to folic acid (GO:0051593)2.46281600
178iron ion homeostasis (GO:0055072)2.44775155
179response to dexamethasone (GO:0071548)2.44455061
180mitotic G2/M transition checkpoint (GO:0044818)2.41791772
181protoporphyrinogen IX metabolic process (GO:0046501)19.2895503
182protoporphyrinogen IX biosynthetic process (GO:0006782)17.8375687
183porphyrin-containing compound biosynthetic process (GO:0006779)13.0029015
184heme biosynthetic process (GO:0006783)12.5983334
185tetrapyrrole biosynthetic process (GO:0033014)11.7435771
186erythrocyte maturation (GO:0043249)10.2502787
187porphyrin-containing compound metabolic process (GO:0006778)10.0629872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.83980455
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.98820515
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.96938300
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.17182653
5GATA1_22025678_ChIP-Seq_K562_Human4.80954765
6* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse4.69531514
7KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse4.51332839
8* GATA1_19941826_ChIP-Seq_K562_Human4.47405878
9SCL_19346495_ChIP-Seq_HPC-7_Human4.42736628
10GATA1_19941827_ChIP-Seq_MEL_Mouse4.17221811
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12112834
12IRF8_22096565_ChIP-ChIP_GC-B_Human4.03611287
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.87217351
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.29430787
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18118237
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.97973157
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78366564
18RUNX_20019798_ChIP-Seq_JUKART_Human2.76189721
19* GATA2_19941826_ChIP-Seq_K562_Human2.69741903
20* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.68910912
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52670618
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.47296308
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.44858849
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.40290253
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37913629
26SPI1_23127762_ChIP-Seq_K562_Human2.21203572
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20148723
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12192809
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.06700733
30SPI1_23547873_ChIP-Seq_NB4_Human1.91270231
31GATA3_27048872_Chip-Seq_THYMUS_Human1.90034598
32* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89456213
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.84077581
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.83980698
35MYC_22102868_ChIP-Seq_BL_Human1.81932544
36SOX2_16153702_ChIP-ChIP_HESCs_Human1.78076713
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73130684
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68138744
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62957678
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.61324419
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59556370
42GATA3_26560356_Chip-Seq_TH2_Human1.59022143
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56837167
44VDR_21846776_ChIP-Seq_THP-1_Human1.54599896
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54572580
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.52784315
47* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52700371
48* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49854486
49* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46928237
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45600091
51VDR_24787735_ChIP-Seq_THP-1_Human1.45569093
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42832944
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40345719
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40155462
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37383268
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.35907647
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35445094
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34178880
59PU_27001747_Chip-Seq_BMDM_Mouse1.33455394
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30901742
61* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30638464
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30163565
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29719653
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.22216337
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.21811551
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21224934
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20785537
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20537652
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19228104
70SMRT_27268052_Chip-Seq_Bcells_Human1.16581024
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15865572
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15843163
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15441798
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.15144651
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15092690
76VDR_23849224_ChIP-Seq_CD4+_Human1.13297054
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12598689
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10091320
79* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09619866
80ETS1_22383799_ChIP-Seq_G1ME_Mouse1.09540357
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09412914
82TP53_16413492_ChIP-PET_HCT116_Human1.08929881
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07816405
84NCOR1_26117541_ChIP-Seq_K562_Human1.06145054
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05948945
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05791885
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04068415
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03934249
89AR_21909140_ChIP-Seq_LNCAP_Human1.03764357
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03718805
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03684097
92GATA3_26560356_Chip-Seq_TH1_Human1.00669491
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00610241
94MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99896539
95CIITA_25753668_ChIP-Seq_RAJI_Human0.98889607
96NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98331926
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97905056
98IRF1_19129219_ChIP-ChIP_H3396_Human0.93886253
99ER_23166858_ChIP-Seq_MCF-7_Human0.93317834
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93271154
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92413353
102VDR_24763502_ChIP-Seq_THP-1_Human0.92080076
103MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91877189
104FLI1_21867929_ChIP-Seq_TH2_Mouse0.91574496
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91482648
106MAF_26560356_Chip-Seq_TH1_Human0.91193767
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.90150472
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89819673
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89139308
110TCF7_22412390_ChIP-Seq_EML_Mouse0.88730794
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.88596000
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88180420
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87706121
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86112694
115BP1_19119308_ChIP-ChIP_Hs578T_Human0.84997981
116UTX_26944678_Chip-Seq_JUKART_Human0.84728159
117GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84127459
118GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82880219
119TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82859692
120STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.82632102
121ZNF263_19887448_ChIP-Seq_K562_Human0.82159820
122KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82156315
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82121750
124MYC_18555785_ChIP-Seq_MESCs_Mouse0.81565382
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81100786
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81092054
127RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80974359
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80758672
129SRF_21415370_ChIP-Seq_HL-1_Mouse0.80666026
130NOTCH1_21737748_ChIP-Seq_TLL_Human0.80357867
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79614468
132OCT4_21477851_ChIP-Seq_ESCs_Mouse0.79078302
133IGF1R_20145208_ChIP-Seq_DFB_Human0.78324756
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.78107404
135KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76989776
136MAF_26560356_Chip-Seq_TH2_Human0.76968963
137FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76610468
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76403236
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.75336601
140SALL4_22934838_ChIP-ChIP_CD34+_Human0.75005360
141ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74847408
142CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73474228
143PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73208385
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73193517
145PADI4_21655091_ChIP-ChIP_MCF-7_Human0.72554290
146HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.70840589
147ELF1_20517297_ChIP-Seq_JURKAT_Human0.70739288
148MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.69615001
149* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.69319210
150STAT1_20625510_ChIP-Seq_HELA_Human0.68819621
151MYB_26560356_Chip-Seq_TH2_Human0.68017140
152KDM2B_26808549_Chip-Seq_DND41_Human0.65729415
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.64625935
154FOXP3_21729870_ChIP-Seq_TREG_Human0.62834236
155TDRD3_21172665_ChIP-Seq_MCF-7_Human0.62696724
156SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.61004580
157KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.59579026
158MYB_26560356_Chip-Seq_TH1_Human0.59311943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.15521372
2MP0003111_abnormal_nucleus_morphology3.43621010
3MP0003724_increased_susceptibility_to3.34530244
4MP0005083_abnormal_biliary_tract2.95967957
5MP0001835_abnormal_antigen_presentation2.82321985
6MP0005397_hematopoietic_system_phenotyp2.76434560
7MP0001545_abnormal_hematopoietic_system2.76434560
8MP0010094_abnormal_chromosome_stability2.48385684
9MP0003763_abnormal_thymus_physiology2.24558817
10MP0002736_abnormal_nociception_after2.12723021
11MP0003172_abnormal_lysosome_physiology2.10242347
12MP0005174_abnormal_tail_pigmentation2.01504133
13MP0003656_abnormal_erythrocyte_physiolo11.8081798
14MP0004147_increased_porphyrin_level11.1014125
15MP0003077_abnormal_cell_cycle1.95032304
16MP0003436_decreased_susceptibility_to1.85878959
17MP0002396_abnormal_hematopoietic_system1.85485138
18MP0004381_abnormal_hair_follicle1.81389042
19MP0002723_abnormal_immune_serum1.79546314
20MP0002419_abnormal_innate_immunity1.79309488
21MP0005636_abnormal_mineral_homeostasis1.74082309
22MP0002452_abnormal_antigen_presenting1.71042027
23MP0005451_abnormal_body_composition1.65528338
24MP0010307_abnormal_tumor_latency1.60800837
25MP0004883_abnormal_blood_vessel1.57711046
26MP0002332_abnormal_exercise_endurance1.53830731
27MP0002398_abnormal_bone_marrow1.52801911
28MP0008260_abnormal_autophagy1.50908538
29MP0002735_abnormal_chemical_nociception1.45751297
30MP0003828_pulmonary_edema1.44109041
31MP0000490_abnormal_crypts_of1.43504296
32MP0008058_abnormal_DNA_repair1.42836152
33MP0002132_abnormal_respiratory_system1.40495806
34MP0009785_altered_susceptibility_to1.40071616
35MP0002166_altered_tumor_susceptibility1.37075386
36MP0006292_abnormal_olfactory_placode1.35326093
37MP0003866_abnormal_defecation1.34744710
38MP0004808_abnormal_hematopoietic_stem1.33044372
39MP0000685_abnormal_immune_system1.28580962
40MP0001968_abnormal_touch/_nociception1.28315851
41MP0008004_abnormal_stomach_pH1.26321571
42MP0003693_abnormal_embryo_hatching1.26215194
43MP0004484_altered_response_of1.25148306
44MP0002148_abnormal_hypersensitivity_rea1.24893718
45MP0004947_skin_inflammation1.23999678
46MP0004130_abnormal_muscle_cell1.22333021
47MP0002722_abnormal_immune_system1.21916311
48MP0006054_spinal_hemorrhage1.21559036
49MP0008872_abnormal_physiological_respon1.19660176
50MP0005464_abnormal_platelet_physiology1.17897536
51MP0005671_abnormal_response_to1.16960888
52MP0008057_abnormal_DNA_replication1.15766586
53MP0000689_abnormal_spleen_morphology1.15680281
54MP0003221_abnormal_cardiomyocyte_apopto1.14865019
55MP0001845_abnormal_inflammatory_respons1.13470504
56MP0002877_abnormal_melanocyte_morpholog1.13241044
57MP0002429_abnormal_blood_cell1.11739921
58MP0000350_abnormal_cell_proliferation1.07515155
59MP0001529_abnormal_vocalization1.07243572
60MP0008770_decreased_survivor_rate1.02341356
61MP0000313_abnormal_cell_death1.01991773
62MP0004957_abnormal_blastocyst_morpholog1.01930188
63MP0001851_eye_inflammation0.99753865
64MP0001188_hyperpigmentation0.97438232
65MP0002095_abnormal_skin_pigmentation0.97105497
66MP0008775_abnormal_heart_ventricle0.96112266
67MP0002019_abnormal_tumor_incidence0.95842881
68MP0009931_abnormal_skin_appearance0.95189455
69MP0008877_abnormal_DNA_methylation0.95156069
70MP0010155_abnormal_intestine_physiology0.92417663
71MP0009764_decreased_sensitivity_to0.90748439
72MP0005164_abnormal_response_to0.90420257
73MP0009278_abnormal_bone_marrow0.88167459
74MP0003186_abnormal_redox_activity0.86349054
75MP0005501_abnormal_skin_physiology0.84767123
76MP0000465_gastrointestinal_hemorrhage0.84356557
77MP0000703_abnormal_thymus_morphology0.83458154
78MP0009765_abnormal_xenobiotic_induced0.82801734
79MP0003183_abnormal_peptide_metabolism0.81683086
80MP0004510_myositis0.81440782
81MP0001533_abnormal_skeleton_physiology0.79640203
82MP0002006_tumorigenesis0.79407082
83MP0009333_abnormal_splenocyte_physiolog0.78832980
84MP0006082_CNS_inflammation0.76658292
85MP0006036_abnormal_mitochondrial_physio0.74266251
86MP0008874_decreased_physiological_sensi0.74261441
87MP0006035_abnormal_mitochondrial_morpho0.73658807
88MP0008789_abnormal_olfactory_epithelium0.73426480
89MP0003300_gastrointestinal_ulcer0.73249151
90MP0005266_abnormal_metabolism0.71092453
91MP0005499_abnormal_olfactory_system0.70978834
92MP0005394_taste/olfaction_phenotype0.70978834
93MP0000249_abnormal_blood_vessel0.66667110
94MP0000716_abnormal_immune_system0.66382563
95MP0005376_homeostasis/metabolism_phenot0.65353720
96MP0008995_early_reproductive_senescence0.64885033
97MP0008469_abnormal_protein_level0.64637889
98MP0001663_abnormal_digestive_system0.63383605
99MP0005084_abnormal_gallbladder_morpholo0.61669675
100MP0000343_altered_response_to0.60544440
101MP0002139_abnormal_hepatobiliary_system0.60379154
102MP0000371_diluted_coat_color0.59875952
103MP0005167_abnormal_blood-brain_barrier0.57640602
104MP0003690_abnormal_glial_cell0.57409449
105MP0001873_stomach_inflammation0.56804433
106MP0010771_integument_phenotype0.55823957
107MP0000230_abnormal_systemic_arterial0.55400004
108MP0009763_increased_sensitivity_to0.53835770
109MP0002136_abnormal_kidney_physiology0.53554392
110MP0005310_abnormal_salivary_gland0.52077356
111MP0003303_peritoneal_inflammation0.50978105
112MP0003787_abnormal_imprinting0.50614318
113MP0008007_abnormal_cellular_replicative0.49980988
114MP0002405_respiratory_system_inflammati0.49103098
115MP0003806_abnormal_nucleotide_metabolis0.48321804
116MP0005025_abnormal_response_to0.47874281
117MP0005621_abnormal_cell_physiology0.46349230
118MP0004859_abnormal_synaptic_plasticity0.46210361
119MP0002080_prenatal_lethality0.46091971
120MP0002086_abnormal_extraembryonic_tissu0.46031146
121MP0000015_abnormal_ear_pigmentation0.45239722
122MP0008932_abnormal_embryonic_tissue0.44689744
123MP0002420_abnormal_adaptive_immunity0.44317794
124MP0005384_cellular_phenotype0.43335733
125MP0001819_abnormal_immune_cell0.43281351
126MP0002083_premature_death0.41941798
127MP0000858_altered_metastatic_potential0.41842143
128MP0004215_abnormal_myocardial_fiber0.40565175
129MP0003786_premature_aging0.40216352
130MP0009672_abnormal_birth_weight0.39300621
131MP0002102_abnormal_ear_morphology0.36938251
132MP0001191_abnormal_skin_condition0.36759229
133MP0005387_immune_system_phenotype0.36686634
134MP0001790_abnormal_immune_system0.36686634
135MP0005000_abnormal_immune_tolerance0.36413332
136MP0000609_abnormal_liver_physiology0.35288501
137MP0002734_abnormal_mechanical_nocicepti0.33500376
138MP0001697_abnormal_embryo_size0.33266364
139MP0002733_abnormal_thermal_nociception0.32468323
140MP0001731_abnormal_postnatal_growth0.31775952
141MP0005075_abnormal_melanosome_morpholog0.31603520
142MP0004142_abnormal_muscle_tone0.31299827
143MP0000598_abnormal_liver_morphology0.31000727
144MP0003868_abnormal_feces_composition0.30862354
145MP0001800_abnormal_humoral_immune0.30794070
146MP0003121_genomic_imprinting0.29920509

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)9.41960937
2Acanthocytosis (HP:0001927)9.28234539
3Reticulocytosis (HP:0001923)8.26863802
4Diaphragmatic weakness (HP:0009113)6.47057252
5Cholelithiasis (HP:0001081)6.29785415
6Abnormality of reticulocytes (HP:0004312)5.77444856
7Abnormal gallbladder morphology (HP:0012437)5.71717287
8Hyperbilirubinemia (HP:0002904)5.24932927
9Osteomalacia (HP:0002749)5.20424620
10Paralysis (HP:0003470)5.17481257
11Gingival bleeding (HP:0000225)5.16242556
12Insomnia (HP:0100785)5.10198476
13Recurrent bacterial skin infections (HP:0005406)4.59710307
14Hypochromic anemia (HP:0001931)4.55859871
15Cutaneous photosensitivity (HP:0000992)4.52397355
16Microcytic anemia (HP:0001935)4.43411190
17T lymphocytopenia (HP:0005403)4.36828317
18Abnormal number of erythroid precursors (HP:0012131)4.17903359
19Abnormality of T cell number (HP:0011839)4.11417679
20Recurrent abscess formation (HP:0002722)4.02517309
21Abnormality of the gallbladder (HP:0005264)3.88228973
22Gastrointestinal infarctions (HP:0005244)3.79867577
23Abnormality of cells of the erythroid lineage (HP:0012130)3.78542589
24Spontaneous hematomas (HP:0007420)3.70182147
25Stomatitis (HP:0010280)3.67502566
26Petechiae (HP:0000967)3.54743750
27Recurrent fungal infections (HP:0002841)3.51585985
28Eczematoid dermatitis (HP:0000976)3.43768778
29Abnormal gallbladder physiology (HP:0012438)3.38620353
30Cholecystitis (HP:0001082)3.38620353
31Prolonged bleeding time (HP:0003010)3.20542240
32Retrobulbar optic neuritis (HP:0100654)3.19791927
33Optic neuritis (HP:0100653)3.19791927
34Visual hallucinations (HP:0002367)3.19665380
35Myositis (HP:0100614)3.19156774
36Elevated erythrocyte sedimentation rate (HP:0003565)3.15991809
37Leukocytosis (HP:0001974)3.12497872
38Postural instability (HP:0002172)2.99902864
39Recurrent skin infections (HP:0001581)2.98428803
40Orchitis (HP:0100796)2.96141273
41Abnormality of T cells (HP:0002843)2.91190867
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.82139650
43Encephalitis (HP:0002383)2.79374575
44Arterial thrombosis (HP:0004420)2.77425920
45Conjunctival telangiectasia (HP:0000524)2.75302756
46Birth length less than 3rd percentile (HP:0003561)2.74271456
47Chronic mucocutaneous candidiasis (HP:0002728)2.72810544
48Recurrent cutaneous fungal infections (HP:0011370)2.72810544
49Hyponatremia (HP:0002902)2.69480108
50Slow saccadic eye movements (HP:0000514)2.68364494
51Ileus (HP:0002595)2.67451300
52Pustule (HP:0200039)2.67253742
53Increased serum ferritin (HP:0003281)2.65737113
54Recurrent viral infections (HP:0004429)2.64479479
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62493152
56Eosinophilia (HP:0001880)2.56556916
57Short middle phalanx of the 5th finger (HP:0004220)2.55626885
58Chromsome breakage (HP:0040012)2.54906616
59Abnormality of the vasculature of the conjunctiva (HP:0008054)2.53457503
60Abnormality of sodium homeostasis (HP:0010931)2.52978967
61Chest pain (HP:0100749)2.49960619
62Autoimmune hemolytic anemia (HP:0001890)2.48909399
63Urticaria (HP:0001025)2.48016347
64Gingivitis (HP:0000230)2.46129750
65Granulocytopenia (HP:0001913)2.45050213
66Chronic obstructive pulmonary disease (HP:0006510)2.44655514
67Obstructive lung disease (HP:0006536)2.44655514
68Keratoconjunctivitis sicca (HP:0001097)2.43698780
69Confusion (HP:0001289)2.41822048
70Peritonitis (HP:0002586)2.41701004
71Abnormality of macrophages (HP:0004311)2.40259222
72Polycythemia (HP:0001901)2.37637904
73Vasculitis (HP:0002633)2.36991638
74Keratoconjunctivitis (HP:0001096)2.34656299
75Episodic fever (HP:0001954)2.30728805
76Recurrent gram-negative bacterial infections (HP:0005420)2.26385540
77Abnormality of eosinophils (HP:0001879)2.25705381
78Abnormality of iron homeostasis (HP:0011031)2.24742105
79Inflammation of the large intestine (HP:0002037)2.24284340
80Autoimmune thrombocytopenia (HP:0001973)2.24281206
81Delusions (HP:0000746)2.23438391
82Abnormal hemoglobin (HP:0011902)2.21732734
83Onycholysis (HP:0001806)2.19362531
84Bruising susceptibility (HP:0000978)2.19287149
85Anorexia (HP:0002039)2.16961146
86Meningitis (HP:0001287)2.16095397
87Dysautonomia (HP:0002459)2.10841155
88Acute hepatic failure (HP:0006554)2.10309023
89Panhypogammaglobulinemia (HP:0003139)2.09440215
90Generalized hyperpigmentation (HP:0007440)2.07209201
91Orthostatic hypotension (HP:0001278)2.05161830
92Gastrointestinal inflammation (HP:0004386)2.02911732
93Seborrheic dermatitis (HP:0001051)2.01339691
94Pallor (HP:0000980)2.00514117
95Abnormality of the heme biosynthetic pathway (HP:0010472)14.1376998
96Poikilocytosis (HP:0004447)13.8882804
97Papillary thyroid carcinoma (HP:0002895)1.99893113
98Epistaxis (HP:0000421)1.98514412
99Abnormality of the preputium (HP:0100587)1.98351508
100Mediastinal lymphadenopathy (HP:0100721)1.96931878
101Hepatocellular carcinoma (HP:0001402)1.96630171
102Abnormality of transition element cation homeostasis (HP:0011030)1.94347615
103Global brain atrophy (HP:0002283)1.94141956
104IgM deficiency (HP:0002850)1.93353556
105Thyroiditis (HP:0100646)1.93338491
106IgA deficiency (HP:0002720)1.92922136
107Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92780062
108Macrocytic anemia (HP:0001972)1.92648955
109Cerebral palsy (HP:0100021)1.92262851
110IgG deficiency (HP:0004315)1.92156526
111Renal tubular acidosis (HP:0001947)1.91914774
112Abnormality of T cell physiology (HP:0011840)1.88584022
113Abnormal hair whorl (HP:0010721)1.86977627
114Purpura (HP:0000979)1.85897650
115Increased IgM level (HP:0003496)1.84942395
116Hypoplasia of the thymus (HP:0000778)1.83999117
117Abnormality of chromosome stability (HP:0003220)1.82911320
118High pitched voice (HP:0001620)1.78858218
119Volvulus (HP:0002580)1.78492999
120Neoplasm of the tracheobronchial system (HP:0100552)1.76937207
121Thrombophlebitis (HP:0004418)1.76864740
122Recurrent bronchitis (HP:0002837)1.75272266
123Stomach cancer (HP:0012126)1.75226349
124Hemoptysis (HP:0002105)1.74573601
125Prostate neoplasm (HP:0100787)1.73906168
126Viral hepatitis (HP:0006562)1.73013532
127Osteomyelitis (HP:0002754)1.72717943
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72587739
129Tinnitus (HP:0000360)1.72087620
130Abnormal platelet function (HP:0011869)1.69909317
131Impaired platelet aggregation (HP:0003540)1.69909317
132Pulmonary infiltrates (HP:0002113)1.69719146
133Pathologic fracture (HP:0002756)1.62554993
134Abnormality of the fingertips (HP:0001211)1.62426312
135Nausea (HP:0002018)1.61791281
136Abnormal blistering of the skin (HP:0008066)1.58245828
137Basal cell carcinoma (HP:0002671)1.57486751
138Abnormal platelet volume (HP:0011876)1.57381867
139Lower limb hyperreflexia (HP:0002395)1.55921135
140Hypopigmented skin patches (HP:0001053)1.53346646
141Protruding tongue (HP:0010808)1.51297649
142Depression (HP:0000716)1.50598679
143Myelodysplasia (HP:0002863)1.50360762
144Small intestinal stenosis (HP:0012848)1.49975007
145Duodenal stenosis (HP:0100867)1.49975007
146Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.49411140
147Increased mean platelet volume (HP:0011877)1.46456598
148Childhood onset (HP:0011463)1.45904089
149Abnormal auditory evoked potentials (HP:0006958)1.45783578
150Broad palm (HP:0001169)1.43139128
151Hypertensive crisis (HP:0100735)1.42936486
152Meckel diverticulum (HP:0002245)1.41812819
153Lymphoma (HP:0002665)1.41136669
154Cafe-au-lait spot (HP:0000957)1.40747248
155Prominent nose (HP:0000448)1.40168557
156Erythema (HP:0010783)1.37394892
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.37176823
158Absent epiphyses (HP:0010577)1.37176823
159Aplasia/Hypoplasia of the uvula (HP:0010293)1.37144354
160Bone marrow hypocellularity (HP:0005528)1.37116612
161Azoospermia (HP:0000027)1.35709590
162Reticulocytopenia (HP:0001896)1.34033398
163Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.33698412
164Cortical visual impairment (HP:0100704)1.32202206
165Abnormality of the ileum (HP:0001549)1.30977145
166Duplicated collecting system (HP:0000081)1.29772716
167Squamous cell carcinoma (HP:0002860)1.29088449
168Anxiety (HP:0000739)1.28722140
169Papilledema (HP:0001085)1.26116810
170Entropion (HP:0000621)1.25524620
171Long nose (HP:0003189)1.23127042
172Menorrhagia (HP:0000132)1.21991575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.81597493
2TLK15.32987588
3RIPK44.43079475
4STK43.89370630
5CDK123.67659224
6ZAK3.64945726
7CDC72.99631112
8VRK12.85477828
9MAP2K32.74505700
10BLK2.49297721
11FGR2.48560610
12FRK2.23308340
13TXK2.10217059
14DYRK32.03574677
15WNK11.91815219
16RPS6KA51.91522200
17BTK1.88843522
18FES1.85984991
19TEC1.85238344
20BRD41.77732634
21BRSK11.76248677
22PIM11.75385577
23PIK3CG1.74693951
24NEK21.74105655
25CSK1.72786426
26PLK21.69301465
27NME21.56335215
28EEF2K1.56216547
29BMPR21.51144077
30IRAK41.50913099
31STK161.49180393
32GRK61.49132870
33AURKB1.48441150
34STK101.47848591
35MAP3K81.43054415
36WEE11.42439269
37MARK31.36779625
38CDK41.36500010
39MAP3K31.35476010
40ZAP701.34922589
41BMX1.31993838
42HCK1.31940928
43INSRR1.28151169
44IKBKB1.27771011
45CDK61.27061928
46MAP3K101.24528214
47TRPM71.24315471
48MAPKAPK51.23010797
49MUSK1.16261572
50CAMKK21.16198355
51SCYL21.16111314
52MAPK111.16075566
53TTK1.13593371
54SYK1.13401538
55PRKAA11.12053633
56ACVR1B1.11950243
57DYRK1B1.10000962
58ITK1.09363613
59IRAK11.08060761
60CHEK21.05621883
61MST41.03667508
62SGK4941.00460802
63TAOK31.00397266
64MAP3K10.99424226
65GRK50.98727910
66MAPKAPK30.96972856
67TGFBR20.95288935
68MAP3K140.94419800
69CAMK1D0.94341150
70MAP3K50.91223418
71CDK90.90202146
72TYK20.89580481
73MAP4K10.88596047
74TNIK0.87985319
75CDK190.87423749
76ATR0.86188622
77LCK0.85904821
78CDK30.85815602
79MARK20.84612344
80AURKA0.84458884
81PLK10.82090185
82NUAK10.80014435
83CSF1R0.79257445
84JAK10.78815710
85JAK20.77974859
86ADRBK10.77346028
87BUB10.75286902
88CCNB10.74694361
89TNK20.74378212
90FGFR30.73389149
91SGK10.70379039
92STK110.70339521
93EIF2AK20.66339974
94CDK70.65495800
95KSR10.65156976
96ATM0.64561515
97MAP3K20.64508193
98MAP3K110.64079483
99YES10.63837350
100CASK0.63790871
101KIT0.63688365
102CHEK10.62985376
103GRK70.62905839
104NLK0.62254283
105RAF10.61407431
106STK240.61376641
107PDK10.59309307
108LYN0.56425891
109CHUK0.56360462
110PTK2B0.55899237
111ADRBK20.55794390
112ERBB20.54574786
113PAK30.54472648
114IRAK20.53931238
115DYRK1A0.53591882
116STK30.52690637
117IKBKE0.51491951
118PLK30.50700406
119RPS6KB20.50569107
120LRRK20.49955714
121MAPK130.49044486
122SGK30.47998611
123MKNK20.46856995
124AKT20.46382385
125BMPR1B0.45745139
126JAK30.44817498
127TAOK20.44335507
128PRKAA20.42613959
129SGK20.42543885
130KDR0.41660078
131MATK0.41055757
132CDK10.40790389
133STK380.40338689
134EPHB10.39819778
135CDK20.39639065
136CAMK40.39558160
137EGFR0.39361113
138PINK10.39145398
139PBK0.39107022
140DAPK20.38728273
141NEK10.37693258
142TAOK10.35433775
143MAPKAPK20.35083682
144CSNK1D0.34566436
145PKN10.34390956
146CAMK1G0.32141770
147CLK10.31726887
148AKT10.31657070
149CDK150.30514246
150CDK11A0.30483816
151BRSK20.30115870
152TBK10.30064653
153MAPK140.29726852
154HIPK20.29380149
155PRKCQ0.28922688
156FYN0.28610696
157PRKCD0.28579269
158MAP3K130.26877517
159MAP3K60.26275780
160MELK0.25425823
161SGK2230.25312928

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008608.06325158
2Systemic lupus erythematosus_Homo sapiens_hsa053227.74688056
3Alcoholism_Homo sapiens_hsa050344.43085903
4DNA replication_Homo sapiens_hsa030303.30688396
5Vitamin B6 metabolism_Homo sapiens_hsa007502.78002785
6Cell cycle_Homo sapiens_hsa041102.61388581
7B cell receptor signaling pathway_Homo sapiens_hsa046622.55590810
8Homologous recombination_Homo sapiens_hsa034402.30517731
9Viral carcinogenesis_Homo sapiens_hsa052032.24471372
10Osteoclast differentiation_Homo sapiens_hsa043802.14321664
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.11391691
12T cell receptor signaling pathway_Homo sapiens_hsa046602.08068236
13Hematopoietic cell lineage_Homo sapiens_hsa046401.97230617
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.95467337
15Fanconi anemia pathway_Homo sapiens_hsa034601.92836737
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.91481388
17Mismatch repair_Homo sapiens_hsa034301.73321952
18Malaria_Homo sapiens_hsa051441.71607569
19Base excision repair_Homo sapiens_hsa034101.68940193
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67673239
21Nucleotide excision repair_Homo sapiens_hsa034201.64340878
22p53 signaling pathway_Homo sapiens_hsa041151.58073959
23Tuberculosis_Homo sapiens_hsa051521.55487098
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51127770
25Sulfur relay system_Homo sapiens_hsa041221.48460323
26ABC transporters_Homo sapiens_hsa020101.33884311
27Staphylococcus aureus infection_Homo sapiens_hsa051501.24161912
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23581199
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23419287
30Legionellosis_Homo sapiens_hsa051341.20979251
31Graft-versus-host disease_Homo sapiens_hsa053321.20081578
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17665839
33One carbon pool by folate_Homo sapiens_hsa006701.15735949
34Nitrogen metabolism_Homo sapiens_hsa009101.15643216
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13285576
36Bladder cancer_Homo sapiens_hsa052191.04155071
37Ribosome_Homo sapiens_hsa030101.03145449
38Inositol phosphate metabolism_Homo sapiens_hsa005621.02652399
39Allograft rejection_Homo sapiens_hsa053301.02110495
40Prolactin signaling pathway_Homo sapiens_hsa049171.01376433
41Pyrimidine metabolism_Homo sapiens_hsa002401.01056495
42Autoimmune thyroid disease_Homo sapiens_hsa053201.00660444
43Herpes simplex infection_Homo sapiens_hsa051681.00592528
44TNF signaling pathway_Homo sapiens_hsa046681.00385720
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00285695
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99148568
47Non-homologous end-joining_Homo sapiens_hsa034500.98345743
48Collecting duct acid secretion_Homo sapiens_hsa049660.98251637
49Endometrial cancer_Homo sapiens_hsa052130.97748201
50African trypanosomiasis_Homo sapiens_hsa051430.96276877
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.95771902
52Non-small cell lung cancer_Homo sapiens_hsa052230.94906879
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92718307
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91859811
55RNA degradation_Homo sapiens_hsa030180.90096729
56mTOR signaling pathway_Homo sapiens_hsa041500.89081712
57VEGF signaling pathway_Homo sapiens_hsa043700.88508942
58Spliceosome_Homo sapiens_hsa030400.87044112
59Dorso-ventral axis formation_Homo sapiens_hsa043200.86724019
60Renal cell carcinoma_Homo sapiens_hsa052110.85886379
61Chronic myeloid leukemia_Homo sapiens_hsa052200.84492829
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84486746
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83118218
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82324907
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80800939
66Measles_Homo sapiens_hsa051620.80772429
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.79476057
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76458552
69Small cell lung cancer_Homo sapiens_hsa052220.75682017
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.75117433
71Phagosome_Homo sapiens_hsa041450.75116621
72Choline metabolism in cancer_Homo sapiens_hsa052310.70855638
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68448637
74Apoptosis_Homo sapiens_hsa042100.67105373
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65972713
76Arachidonic acid metabolism_Homo sapiens_hsa005900.64717455
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62868380
78Hepatitis B_Homo sapiens_hsa051610.61707853
79HIF-1 signaling pathway_Homo sapiens_hsa040660.61330764
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59947180
81Type I diabetes mellitus_Homo sapiens_hsa049400.59146148
82Regulation of autophagy_Homo sapiens_hsa041400.58824620
83Oocyte meiosis_Homo sapiens_hsa041140.58581217
84Type II diabetes mellitus_Homo sapiens_hsa049300.56144014
85RNA transport_Homo sapiens_hsa030130.55146149
86MAPK signaling pathway_Homo sapiens_hsa040100.53708929
87Shigellosis_Homo sapiens_hsa051310.52796737
88Pancreatic cancer_Homo sapiens_hsa052120.52391459
89Endocytosis_Homo sapiens_hsa041440.51715046
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.51651333
91mRNA surveillance pathway_Homo sapiens_hsa030150.50742681
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50685765
93Long-term depression_Homo sapiens_hsa047300.50054627
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49848662
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.49473008
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48997656
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48828262
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48621864
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.47911431
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47732088
101Glycerolipid metabolism_Homo sapiens_hsa005610.47642592
102Purine metabolism_Homo sapiens_hsa002300.46617030
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.46279184
104Cholinergic synapse_Homo sapiens_hsa047250.45893047
105Prostate cancer_Homo sapiens_hsa052150.45686503
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43828122
107Folate biosynthesis_Homo sapiens_hsa007900.43228902
108FoxO signaling pathway_Homo sapiens_hsa040680.43035794
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42271682
110Antigen processing and presentation_Homo sapiens_hsa046120.42100582
111Basal transcription factors_Homo sapiens_hsa030220.41145336
112RNA polymerase_Homo sapiens_hsa030200.39997701
113Glioma_Homo sapiens_hsa052140.38038180
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37195373
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.36701926
116Leishmaniasis_Homo sapiens_hsa051400.36390422
117Thyroid cancer_Homo sapiens_hsa052160.35317913
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.35271059
119Glutathione metabolism_Homo sapiens_hsa004800.34889153
120HTLV-I infection_Homo sapiens_hsa051660.34873689
121Epstein-Barr virus infection_Homo sapiens_hsa051690.33913932
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32531490
123MicroRNAs in cancer_Homo sapiens_hsa052060.31977557
124Asthma_Homo sapiens_hsa053100.31692339
125Acute myeloid leukemia_Homo sapiens_hsa052210.28177487
126Primary immunodeficiency_Homo sapiens_hsa053400.27803548
127Melanoma_Homo sapiens_hsa052180.27510968
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.25692185
129Influenza A_Homo sapiens_hsa051640.25273757
130Olfactory transduction_Homo sapiens_hsa047400.24407313
131Platelet activation_Homo sapiens_hsa046110.22185717
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18245909
133Proteasome_Homo sapiens_hsa030500.17733399
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17658408
135Parkinsons disease_Homo sapiens_hsa050120.17393244
136Lysine degradation_Homo sapiens_hsa003100.15219963
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14206941
138Morphine addiction_Homo sapiens_hsa050320.14102500
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13401518
140Metabolic pathways_Homo sapiens_hsa011000.11890250
141Toxoplasmosis_Homo sapiens_hsa051450.08727546
142Hepatitis C_Homo sapiens_hsa051600.08431764
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.08278837
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.06770018
145AMPK signaling pathway_Homo sapiens_hsa041520.06655403
146Selenocompound metabolism_Homo sapiens_hsa004500.05546670
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.05377456
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05151133
149Huntingtons disease_Homo sapiens_hsa050160.04961657
150Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.02265990
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.02169561
152Chemokine signaling pathway_Homo sapiens_hsa040620.00808399
153Ether lipid metabolism_Homo sapiens_hsa005650.00444068

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