TRIM59

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.48774358
2axon ensheathment in central nervous system (GO:0032291)5.48774358
3DNA unwinding involved in DNA replication (GO:0006268)5.14347836
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.75565418
5DNA double-strand break processing (GO:0000729)4.67665249
6kinetochore organization (GO:0051383)4.66024463
7protein localization to kinetochore (GO:0034501)4.63715645
8negative regulation of DNA-dependent DNA replication (GO:2000104)4.63323129
9mitotic sister chromatid segregation (GO:0000070)4.30348081
10protein localization to chromosome, centromeric region (GO:0071459)4.29445590
11mitotic metaphase plate congression (GO:0007080)4.26383785
12mitotic chromosome condensation (GO:0007076)4.25405522
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.23583945
14sister chromatid segregation (GO:0000819)4.14835879
15DNA strand elongation involved in DNA replication (GO:0006271)4.13789995
16replication fork processing (GO:0031297)4.10016288
17DNA replication initiation (GO:0006270)4.08165157
18attachment of spindle microtubules to kinetochore (GO:0008608)4.07507104
19metaphase plate congression (GO:0051310)4.03931258
20regulation of mitotic spindle checkpoint (GO:1903504)4.02878413
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.02878413
22CENP-A containing nucleosome assembly (GO:0034080)4.02494616
23chromatin remodeling at centromere (GO:0031055)4.00078739
24DNA strand elongation (GO:0022616)3.97808844
25synapsis (GO:0007129)3.95520845
26DNA replication-dependent nucleosome assembly (GO:0006335)3.94018342
27DNA replication-dependent nucleosome organization (GO:0034723)3.94018342
28kinetochore assembly (GO:0051382)3.88815183
29protein K6-linked ubiquitination (GO:0085020)3.80114754
30telomere maintenance via semi-conservative replication (GO:0032201)3.76316117
31regulation of centriole replication (GO:0046599)3.73922537
32regulation of spindle organization (GO:0090224)3.73032869
33nuclear pore organization (GO:0006999)3.71559592
34nuclear pore complex assembly (GO:0051292)3.68266705
35DNA replication-independent nucleosome assembly (GO:0006336)3.67989703
36DNA replication-independent nucleosome organization (GO:0034724)3.67989703
37establishment of chromosome localization (GO:0051303)3.65135520
38somatic hypermutation of immunoglobulin genes (GO:0016446)3.63274760
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.63274760
40positive regulation of chromosome segregation (GO:0051984)3.63228436
41microtubule polymerization or depolymerization (GO:0031109)3.56972925
42DNA ligation (GO:0006266)3.55019656
43meiotic chromosome segregation (GO:0045132)3.54694681
44regulation of DNA endoreduplication (GO:0032875)3.52523712
45resolution of meiotic recombination intermediates (GO:0000712)3.49530638
46maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.48245870
47establishment of integrated proviral latency (GO:0075713)3.47409759
48proteasome assembly (GO:0043248)3.47335512
49establishment of mitotic spindle localization (GO:0040001)3.47120348
50histone exchange (GO:0043486)3.46870655
51regulation of nuclear cell cycle DNA replication (GO:0033262)3.45636208
52regulation of mitotic spindle organization (GO:0060236)3.45295058
53protein localization to chromosome (GO:0034502)3.42736194
54mitotic recombination (GO:0006312)3.41471175
55spindle checkpoint (GO:0031577)3.41346251
56regulation of chromosome segregation (GO:0051983)3.39807163
57DNA catabolic process, exonucleolytic (GO:0000738)3.38408845
58negative regulation of DNA recombination (GO:0045910)3.35821985
59recombinational repair (GO:0000725)3.35461823
60somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.35256781
61somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.35256781
62isotype switching (GO:0045190)3.35256781
63telomere maintenance via recombination (GO:0000722)3.33576255
64regulation of sister chromatid cohesion (GO:0007063)3.32087757
65negative regulation of chromosome segregation (GO:0051985)3.31494228
66double-strand break repair via homologous recombination (GO:0000724)3.31109015
67spindle assembly checkpoint (GO:0071173)3.28916150
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26382787
69negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24630209
70negative regulation of sister chromatid segregation (GO:0033046)3.24630209
71negative regulation of mitotic sister chromatid separation (GO:2000816)3.24630209
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24630209
73mitotic nuclear envelope disassembly (GO:0007077)3.23610012
74microtubule depolymerization (GO:0007019)3.23402154
75DNA replication checkpoint (GO:0000076)3.22851783
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22229491
77DNA topological change (GO:0006265)3.21690710
78negative regulation of translation, ncRNA-mediated (GO:0040033)3.21424767
79regulation of translation, ncRNA-mediated (GO:0045974)3.21424767
80negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.21424767
81chromatin assembly or disassembly (GO:0006333)3.19338198
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19171171
83mitotic spindle assembly checkpoint (GO:0007094)3.17907764
84mitotic spindle checkpoint (GO:0071174)3.17570297
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16736180
86cullin deneddylation (GO:0010388)3.15956395
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15031878
88RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.12729328
89double-strand break repair via nonhomologous end joining (GO:0006303)3.12627568
90non-recombinational repair (GO:0000726)3.12627568
91nucleotide-excision repair, DNA gap filling (GO:0006297)3.12057470
92regulation of exit from mitosis (GO:0007096)3.10961456
93regulation of mitotic metaphase/anaphase transition (GO:0030071)3.09682265
94telomere maintenance via telomere lengthening (GO:0010833)3.08262644
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05427694
96establishment of mitotic spindle orientation (GO:0000132)3.05281307
97regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03922060
98mitotic cytokinesis (GO:0000281)3.03135394
99regulation of centrosome cycle (GO:0046605)3.02833831
100response to X-ray (GO:0010165)3.02172751
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01417626
102regulation of sister chromatid segregation (GO:0033045)3.01386579
103regulation of mitotic sister chromatid separation (GO:0010965)3.01386579
104regulation of mitotic sister chromatid segregation (GO:0033047)3.01386579
105membrane disassembly (GO:0030397)3.00419396
106nuclear envelope disassembly (GO:0051081)3.00419396
107chromosome segregation (GO:0007059)2.99956948
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.99268940
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.99268940
110positive regulation of mitotic sister chromatid separation (GO:1901970)2.99268940
111DNA deamination (GO:0045006)2.97799889
112mitotic sister chromatid cohesion (GO:0007064)2.96389988
113ATP-dependent chromatin remodeling (GO:0043044)2.96175192
114DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.96075869
115regulation of histone H3-K9 methylation (GO:0051570)2.94894309
116histone H2A acetylation (GO:0043968)2.94124503
117chromosome condensation (GO:0030261)2.93768229
118regulation of centrosome duplication (GO:0010824)2.93106864
119DNA strand renaturation (GO:0000733)2.92935136
120regulation of RNA export from nucleus (GO:0046831)2.88992045
121chromatin assembly (GO:0031497)2.86895521
122DNA duplex unwinding (GO:0032508)2.86748007
123DNA geometric change (GO:0032392)2.86620162
124myelin maintenance (GO:0043217)2.85500709
125negative regulation of cell division (GO:0051782)2.85162575
126purine nucleobase biosynthetic process (GO:0009113)2.84939890
127negative regulation of nuclear division (GO:0051784)2.84810642
128protein deneddylation (GO:0000338)2.83881451
129positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83194469
130heterochromatin organization (GO:0070828)2.82749936
131positive regulation of cell cycle checkpoint (GO:1901978)2.82151969
132mitotic G2/M transition checkpoint (GO:0044818)2.74296562
133axon ensheathment (GO:0008366)2.73181942
134ensheathment of neurons (GO:0007272)2.73181942
135negative regulation of mRNA processing (GO:0050686)2.72783232
136spindle assembly involved in mitosis (GO:0090307)2.71766183
137myelination (GO:0042552)2.69174810
138negative regulation of mitosis (GO:0045839)2.68245663
139regulation of telomere maintenance via telomerase (GO:0032210)2.68026260
140DNA damage response, signal transduction resulting in transcription (GO:0042772)2.67679481
141DNA conformation change (GO:0071103)2.66677836
142pore complex assembly (GO:0046931)2.65758904
143negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.64353752
144centriole replication (GO:0007099)2.63756826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.73398385
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.85528504
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.71261536
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.25214448
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.62749090
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.21873675
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03851326
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.93656934
9AR_21909140_ChIP-Seq_LNCAP_Human2.83982860
10ZNF274_21170338_ChIP-Seq_K562_Hela2.76186053
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64895645
12VDR_22108803_ChIP-Seq_LS180_Human2.60316943
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58426547
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50066207
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47872500
16* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46130831
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.45537739
18EWS_26573619_Chip-Seq_HEK293_Human2.33439529
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.23416213
20XRN2_22483619_ChIP-Seq_HELA_Human2.19500286
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15863220
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12220703
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08226892
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04412677
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02490425
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.01149667
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.99673722
28FUS_26573619_Chip-Seq_HEK293_Human1.96530232
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85871069
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.85515691
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78387465
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.77842732
33IGF1R_20145208_ChIP-Seq_DFB_Human1.77269600
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74905568
35VDR_23849224_ChIP-Seq_CD4+_Human1.74277913
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72650833
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66963062
38* P300_19829295_ChIP-Seq_ESCs_Human1.65952549
39TAF15_26573619_Chip-Seq_HEK293_Human1.65567712
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64362347
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60440259
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59653949
43ELK1_19687146_ChIP-ChIP_HELA_Human1.57633429
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57558812
45TTF2_22483619_ChIP-Seq_HELA_Human1.52801926
46FOXP3_21729870_ChIP-Seq_TREG_Human1.51564100
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50658467
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49167255
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48687903
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47480317
51DCP1A_22483619_ChIP-Seq_HELA_Human1.47174562
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41842115
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41490429
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.39905780
55MYC_22102868_ChIP-Seq_BL_Human1.38781748
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38660834
57GBX2_23144817_ChIP-Seq_PC3_Human1.38436692
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.36687769
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36441202
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36288394
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35943207
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34687215
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34687215
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34687215
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31775169
66KDM5A_27292631_Chip-Seq_BREAST_Human1.31277789
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.30861084
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30136530
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29179171
70* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29140729
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.28586033
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28089925
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28044245
74CIITA_25753668_ChIP-Seq_RAJI_Human1.25962748
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25745748
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25305136
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24416252
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24372944
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22185060
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21940416
81IRF1_19129219_ChIP-ChIP_H3396_Human1.21253804
82* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21109893
83GABP_19822575_ChIP-Seq_HepG2_Human1.20383116
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19537501
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.19225802
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.18863333
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18734221
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.18515314
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17931660
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.17059529
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.16327575
92* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14929615
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14308151
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13571540
95* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13272568
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12939692
97VDR_21846776_ChIP-Seq_THP-1_Human1.12098940
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10008256
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09173154
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08885162
101TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08087141
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07570090
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05706091
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05658608
105ER_23166858_ChIP-Seq_MCF-7_Human1.04598261
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03821393
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03421026
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02148540
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00698509
110* SOX2_19829295_ChIP-Seq_ESCs_Human1.00533567
111* NANOG_19829295_ChIP-Seq_ESCs_Human1.00533567
112BCAT_22108803_ChIP-Seq_LS180_Human0.99980507
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99723451
114PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99026029
115* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98122389
116CRX_20693478_ChIP-Seq_RETINA_Mouse0.97441703
117FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96820853
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96020868
119TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95544042
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95383720
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95139514
122* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94981302
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94882829
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94768377
125TFEB_21752829_ChIP-Seq_HELA_Human0.94414279
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94160009
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93089267
128CBP_20019798_ChIP-Seq_JUKART_Human0.93089267
129TCF4_22108803_ChIP-Seq_LS180_Human0.92454653
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.92042687
131KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91197419
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90879363
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.90785246
134SMAD4_21799915_ChIP-Seq_A2780_Human0.90664484
135POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90466349
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.89726761
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.89217936
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88924826
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88265666
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87896007
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87636888
142MYC_18940864_ChIP-ChIP_HL60_Human0.86865158
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86696410
144KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86215036
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84352128
146ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84161324
147SOX17_20123909_ChIP-Seq_XEN_Mouse0.84123683
148EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81017464
149SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79369180
150PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79102411
151SOX2_18692474_ChIP-Seq_MESCs_Mouse0.77129792
152SCL_19346495_ChIP-Seq_HPC-7_Human0.76909601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.76887475
2MP0003111_abnormal_nucleus_morphology3.70889269
3MP0008057_abnormal_DNA_replication3.58890544
4MP0003077_abnormal_cell_cycle3.42572418
5MP0004957_abnormal_blastocyst_morpholog3.30976689
6MP0003693_abnormal_embryo_hatching3.27177920
7MP0006292_abnormal_olfactory_placode3.25589284
8MP0008932_abnormal_embryonic_tissue2.52306746
9MP0003950_abnormal_plasma_membrane2.43438916
10MP0003195_calcinosis2.31717617
11MP0008058_abnormal_DNA_repair2.30404999
12MP0008877_abnormal_DNA_methylation2.20232092
13MP0006072_abnormal_retinal_apoptosis2.17728613
14MP0001730_embryonic_growth_arrest2.17565794
15MP0008007_abnormal_cellular_replicative2.16186014
16MP0000350_abnormal_cell_proliferation2.12359390
17MP0010030_abnormal_orbit_morphology2.11946718
18MP0003123_paternal_imprinting1.95845939
19MP0008789_abnormal_olfactory_epithelium1.90163717
20MP0003937_abnormal_limbs/digits/tail_de1.87949270
21MP0000920_abnormal_myelination1.84877661
22MP0000537_abnormal_urethra_morphology1.77967676
23MP0002837_dystrophic_cardiac_calcinosis1.74471514
24MP0009697_abnormal_copulation1.72138360
25MP0003121_genomic_imprinting1.69994604
26MP0002085_abnormal_embryonic_tissue1.69940097
27MP0002396_abnormal_hematopoietic_system1.67731872
28MP0003941_abnormal_skin_development1.65100076
29MP0000566_synostosis1.60904977
30MP0001697_abnormal_embryo_size1.59014774
31MP0002084_abnormal_developmental_patter1.56510219
32MP0004197_abnormal_fetal_growth/weight/1.54252025
33MP0001293_anophthalmia1.53393550
34MP0001672_abnormal_embryogenesis/_devel1.50988883
35MP0005380_embryogenesis_phenotype1.50988883
36MP0003136_yellow_coat_color1.49049456
37MP0000383_abnormal_hair_follicle1.48977042
38MP0005253_abnormal_eye_physiology1.45481277
39MP0010352_gastrointestinal_tract_polyps1.44215493
40MP0010678_abnormal_skin_adnexa1.41332320
41MP0005367_renal/urinary_system_phenotyp1.39589371
42MP0000516_abnormal_urinary_system1.39589371
43MP0002751_abnormal_autonomic_nervous1.35959678
44MP0005395_other_phenotype1.33165315
45MP0002080_prenatal_lethality1.32903150
46MP0002160_abnormal_reproductive_system1.29282489
47MP0005551_abnormal_eye_electrophysiolog1.28125681
48MP0004133_heterotaxia1.27994299
49MP0002938_white_spotting1.26574805
50MP0001529_abnormal_vocalization1.26119163
51MP0002234_abnormal_pharynx_morphology1.25999985
52MP0003984_embryonic_growth_retardation1.25268121
53MP0000372_irregular_coat_pigmentation1.24749149
54MP0000733_abnormal_muscle_development1.23324762
55MP0000490_abnormal_crypts_of1.22579641
56MP0003890_abnormal_embryonic-extraembry1.20798468
57MP0003315_abnormal_perineum_morphology1.20630547
58MP0002088_abnormal_embryonic_growth/wei1.19618942
59MP0000313_abnormal_cell_death1.19452703
60MP0003656_abnormal_erythrocyte_physiolo1.16970385
61MP0010307_abnormal_tumor_latency1.16204202
62MP0002086_abnormal_extraembryonic_tissu1.15830773
63MP0005394_taste/olfaction_phenotype1.15571187
64MP0005499_abnormal_olfactory_system1.15571187
65MP0009053_abnormal_anal_canal1.15342537
66MP0000428_abnormal_craniofacial_morphol1.14736710
67MP0000427_abnormal_hair_cycle1.12992541
68MP0002210_abnormal_sex_determination1.11859669
69MP0003567_abnormal_fetal_cardiomyocyte1.11410677
70MP0002092_abnormal_eye_morphology1.10271411
71MP0002111_abnormal_tail_morphology1.08827279
72MP0000631_abnormal_neuroendocrine_gland1.08557014
73MP0003938_abnormal_ear_development1.07420571
74MP0002932_abnormal_joint_morphology1.06978212
75MP0004215_abnormal_myocardial_fiber1.05956831
76MP0002019_abnormal_tumor_incidence1.04923355
77MP0005623_abnormal_meninges_morphology1.04852284
78MP0001929_abnormal_gametogenesis1.04301143
79MP0003786_premature_aging1.03979476
80MP0001145_abnormal_male_reproductive1.03658160
81MP0001119_abnormal_female_reproductive1.02098447
82MP0003880_abnormal_central_pattern1.01939520
83MP0000462_abnormal_digestive_system1.01882328
84MP0005389_reproductive_system_phenotype1.01644159
85MP0005171_absent_coat_pigmentation1.00308213
86MP0006054_spinal_hemorrhage0.99983418
87MP0001485_abnormal_pinna_reflex0.97678762
88MP0008872_abnormal_physiological_respon0.96607359
89MP0003755_abnormal_palate_morphology0.95991075
90MP0009333_abnormal_splenocyte_physiolog0.95906175
91MP0001286_abnormal_eye_development0.95547549
92MP0000432_abnormal_head_morphology0.95515020
93MP0001188_hyperpigmentation0.95481945
94MP0002638_abnormal_pupillary_reflex0.95343139
95MP0001984_abnormal_olfaction0.94708854
96MP0004147_increased_porphyrin_level0.93101613
97MP0003861_abnormal_nervous_system0.93031251
98MP0001849_ear_inflammation0.90742834
99MP0003698_abnormal_male_reproductive0.89617198
100MP0008995_early_reproductive_senescence0.89256456
101MP0000703_abnormal_thymus_morphology0.89217201
102MP0006035_abnormal_mitochondrial_morpho0.86459236
103MP0003718_maternal_effect0.86190614
104MP0009250_abnormal_appendicular_skeleto0.86169944
105MP0000762_abnormal_tongue_morphology0.84956978
106MP0002114_abnormal_axial_skeleton0.84893890
107MP0003119_abnormal_digestive_system0.84720406
108MP0005391_vision/eye_phenotype0.84160652
109MP0000049_abnormal_middle_ear0.84129077
110MP0000653_abnormal_sex_gland0.84002177
111MP0006036_abnormal_mitochondrial_physio0.83975798
112MP0001243_abnormal_dermal_layer0.83476813
113MP0003935_abnormal_craniofacial_develop0.83324421
114MP0001177_atelectasis0.83204316
115MP0002736_abnormal_nociception_after0.82516802
116MP0002697_abnormal_eye_size0.82401084
117MP0005501_abnormal_skin_physiology0.82359807
118MP0003115_abnormal_respiratory_system0.81610739
119MP0004808_abnormal_hematopoietic_stem0.81034222
120MP0009703_decreased_birth_body0.80998076
121MP0003806_abnormal_nucleotide_metabolis0.80415820
122MP0009672_abnormal_birth_weight0.79709244
123MP0000647_abnormal_sebaceous_gland0.79097183
124MP0000569_abnormal_digit_pigmentation0.79005277
125MP0004134_abnormal_chest_morphology0.78857622
126MP0005076_abnormal_cell_differentiation0.78729634
127MP0002249_abnormal_larynx_morphology0.78625717
128MP0002653_abnormal_ependyma_morphology0.78319819
129MP0002398_abnormal_bone_marrow0.77557573
130MP0002254_reproductive_system_inflammat0.75657498
131MP0002163_abnormal_gland_morphology0.74892665
132MP0001340_abnormal_eyelid_morphology0.73993553
133MP0003385_abnormal_body_wall0.73639655
134MP0003137_abnormal_impulse_conducting0.73400427
135MP0005075_abnormal_melanosome_morpholog0.73174299
136MP0000377_abnormal_hair_follicle0.73012024
137MP0001348_abnormal_lacrimal_gland0.72977665
138MP0002102_abnormal_ear_morphology0.72638234
139MP0002090_abnormal_vision0.72587946
140MP0000467_abnormal_esophagus_morphology0.71841231
141MP0001764_abnormal_homeostasis0.70502281
142MP0002233_abnormal_nose_morphology0.70463547
143MP0001486_abnormal_startle_reflex0.70387627
144MP0005195_abnormal_posterior_eye0.69987244
145MP0005084_abnormal_gallbladder_morpholo0.69765443
146MP0003787_abnormal_imprinting0.69025221
147MP0001919_abnormal_reproductive_system0.68197567
148MP0002282_abnormal_trachea_morphology0.67268123
149MP0004145_abnormal_muscle_electrophysio0.66687453
150MP0005248_abnormal_Harderian_gland0.62912107
151MP0003122_maternal_imprinting0.61511155

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)3.56167197
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.42377422
3Degeneration of the lateral corticospinal tracts (HP:0002314)3.42377422
4Birth length less than 3rd percentile (HP:0003561)3.17213744
5Absent radius (HP:0003974)3.09285161
6Pancreatic cysts (HP:0001737)3.07281514
7Abnormality of the labia minora (HP:0012880)2.96139743
8Breast hypoplasia (HP:0003187)2.93864155
9Aplasia involving forearm bones (HP:0009822)2.89318810
10Absent forearm bone (HP:0003953)2.89318810
11Abnormality of midbrain morphology (HP:0002418)2.79983707
12Molar tooth sign on MRI (HP:0002419)2.79983707
13Esophageal atresia (HP:0002032)2.79880153
14Abnormal auditory evoked potentials (HP:0006958)2.78533850
15Duplicated collecting system (HP:0000081)2.77159585
16Pancreatic fibrosis (HP:0100732)2.74128403
17Selective tooth agenesis (HP:0001592)2.72456472
18True hermaphroditism (HP:0010459)2.69388232
19Chromsome breakage (HP:0040012)2.66935136
20Absent septum pellucidum (HP:0001331)2.62955336
21Abnormal lung lobation (HP:0002101)2.61542089
22Neoplasm of the oral cavity (HP:0100649)2.57676662
23Clubbing of toes (HP:0100760)2.56773036
24Pendular nystagmus (HP:0012043)2.56506435
25Volvulus (HP:0002580)2.53633865
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52316451
27Stenosis of the external auditory canal (HP:0000402)2.51202676
28Ectopic kidney (HP:0000086)2.51165561
29Nephronophthisis (HP:0000090)2.48334171
30Methylmalonic acidemia (HP:0002912)2.47212460
31Intestinal atresia (HP:0011100)2.45816784
32Abnormal number of incisors (HP:0011064)2.44654724
33Proximal placement of thumb (HP:0009623)2.42241355
34Asplenia (HP:0001746)2.41823805
35Medulloblastoma (HP:0002885)2.41134275
36Colon cancer (HP:0003003)2.40864556
37Glioma (HP:0009733)2.40733522
38Increased nuchal translucency (HP:0010880)2.39775046
39Rhabdomyosarcoma (HP:0002859)2.39390176
40Sensory axonal neuropathy (HP:0003390)2.39083533
41Abnormality of the septum pellucidum (HP:0007375)2.38729644
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37068115
43Short 4th metacarpal (HP:0010044)2.37068115
44Abnormality of the renal collecting system (HP:0004742)2.36408287
45Neoplasm of the adrenal cortex (HP:0100641)2.34733875
46Patellar aplasia (HP:0006443)2.32107975
47Peripheral hypomyelination (HP:0007182)2.31359602
48Reticulocytopenia (HP:0001896)2.30300996
49Anteriorly placed anus (HP:0001545)2.30245215
50Hypoplastic pelvis (HP:0008839)2.29314379
51Supernumerary spleens (HP:0009799)2.26642590
52Abnormality of the heme biosynthetic pathway (HP:0010472)2.25521286
53Deviation of the thumb (HP:0009603)2.25246495
54Diaphragmatic weakness (HP:0009113)2.24418501
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.23397169
56Aplasia/Hypoplasia of the patella (HP:0006498)2.19270908
57Absent thumb (HP:0009777)2.18100071
58Septo-optic dysplasia (HP:0100842)2.16362700
59Abnormality of the carotid arteries (HP:0005344)2.16273114
60Duodenal stenosis (HP:0100867)2.13689149
61Small intestinal stenosis (HP:0012848)2.13689149
62Facial hemangioma (HP:0000329)2.13331720
63Abnormality of the astrocytes (HP:0100707)2.13246444
64Astrocytoma (HP:0009592)2.13246444
65Carpal bone hypoplasia (HP:0001498)2.12856513
66Myelodysplasia (HP:0002863)2.12567574
67Alacrima (HP:0000522)2.12405221
68Acute necrotizing encephalopathy (HP:0006965)2.10932931
69Morphological abnormality of the inner ear (HP:0011390)2.08963121
70Abnormality of the renal medulla (HP:0100957)2.07724341
71Dandy-Walker malformation (HP:0001305)2.06541996
72Acute encephalopathy (HP:0006846)2.05273309
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04775686
74Hypoplasia of the pons (HP:0012110)2.04742041
75Nephroblastoma (Wilms tumor) (HP:0002667)2.03789696
76Abnormality of the pons (HP:0007361)2.03071001
77Abnormality of chromosome stability (HP:0003220)2.02621103
78Small hand (HP:0200055)2.01590141
79Atresia of the external auditory canal (HP:0000413)2.01174619
80Progressive macrocephaly (HP:0004481)2.00898435
81Basal cell carcinoma (HP:0002671)2.00343378
82Pancreatic islet-cell hyperplasia (HP:0004510)2.00305495
83Neoplasm of the colon (HP:0100273)1.99756338
84Abnormality of the renal cortex (HP:0011035)1.99063259
85Abnormality of the ileum (HP:0001549)1.98776155
86Meckel diverticulum (HP:0002245)1.98642006
87Overriding aorta (HP:0002623)1.98364294
88Medial flaring of the eyebrow (HP:0010747)1.97681021
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.97184533
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96926682
91CNS hypomyelination (HP:0003429)1.96511418
92Partial duplication of the phalanx of hand (HP:0009999)1.96334924
93Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95809577
94Abnormality of the corticospinal tract (HP:0002492)1.94814863
95Increased CSF lactate (HP:0002490)1.93227711
96Hyperglycinemia (HP:0002154)1.92736645
97Neoplasm of the adrenal gland (HP:0100631)1.91045127
98Gastrointestinal atresia (HP:0002589)1.90039874
99Partial duplication of thumb phalanx (HP:0009944)1.89814764
100Duplication of thumb phalanx (HP:0009942)1.89623873
101Optic nerve hypoplasia (HP:0000609)1.89597543
102Methylmalonic aciduria (HP:0012120)1.89377253
103Embryonal renal neoplasm (HP:0011794)1.89047051
104Abnormality of the calcaneus (HP:0008364)1.88769599
105Anencephaly (HP:0002323)1.88601749
106Chin dimple (HP:0010751)1.88432899
107Decreased lacrimation (HP:0000633)1.88280786
108Rib fusion (HP:0000902)1.88225397
109Supernumerary bones of the axial skeleton (HP:0009144)1.88210762
110Abnormality of the phalanges of the 2nd finger (HP:0009541)1.87283323
111Broad distal phalanx of finger (HP:0009836)1.87130196
112Abnormality of methionine metabolism (HP:0010901)1.87017471
113Abnormality of the duodenum (HP:0002246)1.86768432
114Breast carcinoma (HP:0003002)1.85717148
115Supernumerary ribs (HP:0005815)1.84524367
116Hypochromic microcytic anemia (HP:0004840)1.83606408
117Ulnar bowing (HP:0003031)1.83215032
118Sloping forehead (HP:0000340)1.82804474
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.82629324
120Abnormality of the fetal cardiovascular system (HP:0010948)1.82523174
121Abnormal umbilical cord blood vessels (HP:0011403)1.82523174
122Single umbilical artery (HP:0001195)1.82523174
123Premature skin wrinkling (HP:0100678)1.81864848
124Impulsivity (HP:0100710)1.81235545
125Premature graying of hair (HP:0002216)1.80991636
126Coronal craniosynostosis (HP:0004440)1.80986739
127Microtia (HP:0008551)1.79633621
128Ependymoma (HP:0002888)1.79318620
129Preaxial hand polydactyly (HP:0001177)1.78908221
130Oligodactyly (hands) (HP:0001180)1.78801980
131Abnormality of the salivary glands (HP:0010286)1.77521085
132Congenital stationary night blindness (HP:0007642)1.76490243
133Mitochondrial inheritance (HP:0001427)1.76259488
134Termporal pattern (HP:0011008)1.75769453
135Insidious onset (HP:0003587)1.75769453
136Abolished electroretinogram (ERG) (HP:0000550)1.75048367
137Abnormality of serum amino acid levels (HP:0003112)1.75007347
138Thyroiditis (HP:0100646)1.74417215
139Abnormality of the preputium (HP:0100587)1.74340812
140Fused cervical vertebrae (HP:0002949)1.74055165
141Agnosia (HP:0010524)1.74014129
142Progressive inability to walk (HP:0002505)1.73588728
143Horseshoe kidney (HP:0000085)1.72858955
144Triphalangeal thumb (HP:0001199)1.72789265
145Prominent occiput (HP:0000269)1.72324809
146Short thumb (HP:0009778)1.71585199
147Rectal fistula (HP:0100590)1.71070607
148Rectovaginal fistula (HP:0000143)1.71070607
149Shallow orbits (HP:0000586)1.70499893
150Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70379481
151Oligohydramnios (HP:0001562)1.69933080
152Astigmatism (HP:0000483)1.69794325
153Sclerocornea (HP:0000647)1.69117299
154Aqueductal stenosis (HP:0002410)1.68025872
155Increased hepatocellular lipid droplets (HP:0006565)1.65336235
156Ovarian neoplasm (HP:0100615)1.63983645
157Abnormal mitochondria in muscle tissue (HP:0008316)1.63150428
158Renal cortical cysts (HP:0000803)1.62465487
159Genital tract atresia (HP:0001827)1.61804445
160Holoprosencephaly (HP:0001360)1.59329481
161Congenital primary aphakia (HP:0007707)1.58461370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.49134655
2CDC74.35764885
3WEE13.20178691
4FRK2.94374652
5STK392.93041222
6TESK22.63602860
7ZAK2.61346076
8NUAK12.55104315
9NEK22.52937317
10PBK2.44907600
11WNK32.42760430
12MKNK12.35754912
13TRIM282.33210357
14STK102.31277493
15TTK2.22226610
16TNIK2.15307497
17VRK22.13721642
18BMPR1B2.05425628
19TLK11.92080098
20CDK121.86963793
21CLK11.85959545
22EIF2AK11.75855349
23BRSK21.62858154
24MELK1.61268315
25PLK11.59476661
26MET1.56935704
27OXSR11.56206496
28UHMK11.55602917
29SRPK11.54262236
30AURKB1.50748226
31MAP3K81.50475010
32STK41.50406915
33TAF11.49228795
34MKNK21.47083016
35MST41.46171888
36MAP4K21.44842031
37BRD41.42797631
38DYRK31.38617960
39BRSK11.37227088
40CHEK21.36324194
41LIMK11.34940244
42ERBB31.34330813
43PLK21.32006057
44VRK11.31753067
45CDK71.29895963
46GRK11.27716368
47BCR1.22231166
48CSNK1A1L1.20676217
49CHEK11.19642992
50ACVR1B1.18241402
51CSNK1G31.17556843
52ATR1.15400103
53PLK31.13858005
54AURKA1.13513187
55RPS6KB21.11103501
56PASK1.10301300
57PLK41.09546527
58EIF2AK21.07615068
59LRRK21.04956268
60PNCK1.04111620
61PKN11.02687613
62STK38L1.01855846
63CDK191.01821073
64CDK40.98308258
65FGFR20.95619862
66MUSK0.94552436
67MAPKAPK50.93575840
68NLK0.92794234
69TGFBR10.91143176
70CSNK1G10.87532163
71ADRBK20.87328332
72MAPK130.86279061
73ATM0.85956848
74RPS6KA50.84524799
75CDK60.84188911
76TRPM70.81692472
77ROCK20.81164020
78PAK10.80299849
79MAP4K10.79862491
80STK30.78940560
81CCNB10.78370870
82MAP3K40.76986966
83CDK20.76853609
84MAP3K100.76738790
85EIF2AK30.75750528
86DYRK20.75420732
87CDK10.75065572
88EEF2K0.72478171
89NEK60.72070260
90INSRR0.71873748
91FGR0.71483091
92WNK10.71148043
93TSSK60.70844584
94LATS10.70793590
95RPS6KA40.69235869
96NEK10.69157735
97STK160.68922749
98CSNK1D0.67185306
99ICK0.66706728
100CDK150.60920203
101TIE10.60403207
102EPHA20.60286747
103CDK11A0.60068769
104PAK20.59564372
105CDK140.58268834
106CDK180.55574004
107EPHA40.55326152
108PAK40.55150162
109CSNK1G20.52944877
110CSF1R0.49677459
111PAK30.48923794
112ALK0.48625448
113NME20.47720955
114BMX0.47369049
115CSNK2A20.46256430
116NME10.46172965
117EPHB10.44072781
118PIM10.43487994
119PRKCI0.43358205
120PRKCG0.43351254
121AKT30.41732879
122FLT30.41331214
123PRKCE0.40716538
124PRKDC0.40160129
125CASK0.39747370
126BCKDK0.39489552
127CSNK2A10.39071363
128FGFR10.37442882
129MAPKAPK20.36953945
130WNK40.36444160
131TYRO30.35884539
132TESK10.35376166
133CSNK1E0.34551241
134SCYL20.34219015
135CDK90.32998963
136DMPK0.32047137
137MARK30.29312917
138BRAF0.28605867
139CDK80.27285516
140CDK30.26304850
141PINK10.25532274
142MINK10.25289845
143MAP2K70.21548757

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.55994960
2Mismatch repair_Homo sapiens_hsa034304.02974979
3Spliceosome_Homo sapiens_hsa030403.26279023
4Cell cycle_Homo sapiens_hsa041103.23663975
5Homologous recombination_Homo sapiens_hsa034402.74969598
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65886689
7Base excision repair_Homo sapiens_hsa034102.62075356
8RNA transport_Homo sapiens_hsa030132.61459509
9Nucleotide excision repair_Homo sapiens_hsa034202.57012344
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47597360
11Non-homologous end-joining_Homo sapiens_hsa034502.35778439
12Ribosome_Homo sapiens_hsa030102.31367362
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21547033
14RNA polymerase_Homo sapiens_hsa030202.17573010
15Fanconi anemia pathway_Homo sapiens_hsa034602.12623071
16Propanoate metabolism_Homo sapiens_hsa006402.06714317
17Systemic lupus erythematosus_Homo sapiens_hsa053221.97950001
18One carbon pool by folate_Homo sapiens_hsa006701.89027106
19Basal transcription factors_Homo sapiens_hsa030221.88658184
20RNA degradation_Homo sapiens_hsa030181.87623951
21mRNA surveillance pathway_Homo sapiens_hsa030151.83435621
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81945721
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66539125
24p53 signaling pathway_Homo sapiens_hsa041151.65669870
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65401368
26Proteasome_Homo sapiens_hsa030501.63919868
27Pyrimidine metabolism_Homo sapiens_hsa002401.55442827
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53432792
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49659474
30Phototransduction_Homo sapiens_hsa047441.44582720
31Viral carcinogenesis_Homo sapiens_hsa052031.40780158
32Butanoate metabolism_Homo sapiens_hsa006501.31759515
33Oxidative phosphorylation_Homo sapiens_hsa001901.29888179
34Steroid biosynthesis_Homo sapiens_hsa001001.25163005
35Oocyte meiosis_Homo sapiens_hsa041141.24505986
36MicroRNAs in cancer_Homo sapiens_hsa052061.23237765
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19834843
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18947962
39Parkinsons disease_Homo sapiens_hsa050121.18256770
40Ether lipid metabolism_Homo sapiens_hsa005651.17806744
41Basal cell carcinoma_Homo sapiens_hsa052171.15475254
42Vitamin B6 metabolism_Homo sapiens_hsa007501.14885096
43Alcoholism_Homo sapiens_hsa050341.12310817
44Pyruvate metabolism_Homo sapiens_hsa006201.12108775
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11739985
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10875000
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08196141
48Hedgehog signaling pathway_Homo sapiens_hsa043401.02626005
49Epstein-Barr virus infection_Homo sapiens_hsa051691.02609234
50Primary immunodeficiency_Homo sapiens_hsa053401.02500838
51Hippo signaling pathway_Homo sapiens_hsa043900.99609635
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97978334
53Nitrogen metabolism_Homo sapiens_hsa009100.97459702
54Small cell lung cancer_Homo sapiens_hsa052220.94631919
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93994261
56Huntingtons disease_Homo sapiens_hsa050160.91307423
57HTLV-I infection_Homo sapiens_hsa051660.89501525
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.86487070
59Tight junction_Homo sapiens_hsa045300.86229196
60Tryptophan metabolism_Homo sapiens_hsa003800.86136951
61Herpes simplex infection_Homo sapiens_hsa051680.86101437
62Caffeine metabolism_Homo sapiens_hsa002320.83324506
63Renal cell carcinoma_Homo sapiens_hsa052110.83196038
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82973245
65Notch signaling pathway_Homo sapiens_hsa043300.82808811
66Purine metabolism_Homo sapiens_hsa002300.82065107
67TGF-beta signaling pathway_Homo sapiens_hsa043500.79623040
68Fatty acid elongation_Homo sapiens_hsa000620.79604680
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79083010
70Sulfur metabolism_Homo sapiens_hsa009200.73735534
71Folate biosynthesis_Homo sapiens_hsa007900.69418348
72Linoleic acid metabolism_Homo sapiens_hsa005910.68770145
73Shigellosis_Homo sapiens_hsa051310.67848089
74Peroxisome_Homo sapiens_hsa041460.67692793
75beta-Alanine metabolism_Homo sapiens_hsa004100.66475265
76Pathways in cancer_Homo sapiens_hsa052000.66370776
77Antigen processing and presentation_Homo sapiens_hsa046120.65984015
78Wnt signaling pathway_Homo sapiens_hsa043100.64996622
79Prostate cancer_Homo sapiens_hsa052150.64121336
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63568858
81Protein export_Homo sapiens_hsa030600.63157413
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.62546056
83Colorectal cancer_Homo sapiens_hsa052100.62401749
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62345175
85Axon guidance_Homo sapiens_hsa043600.61181650
86Metabolic pathways_Homo sapiens_hsa011000.59680796
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58087286
88Chronic myeloid leukemia_Homo sapiens_hsa052200.55675546
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54343235
90Pancreatic cancer_Homo sapiens_hsa052120.53733623
91Glutathione metabolism_Homo sapiens_hsa004800.52612939
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51879802
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51256737
94Alzheimers disease_Homo sapiens_hsa050100.50706794
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50608768
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50424174
97Hematopoietic cell lineage_Homo sapiens_hsa046400.49589526
98Retinol metabolism_Homo sapiens_hsa008300.49124091
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48910319
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48789872
101Viral myocarditis_Homo sapiens_hsa054160.48600737
102Adherens junction_Homo sapiens_hsa045200.48004370
103Bladder cancer_Homo sapiens_hsa052190.47019315
104T cell receptor signaling pathway_Homo sapiens_hsa046600.46705532
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46658840
106Vitamin digestion and absorption_Homo sapiens_hsa049770.45998545
107Lysine degradation_Homo sapiens_hsa003100.45176851
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45025784
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44922463
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43984551
111Proteoglycans in cancer_Homo sapiens_hsa052050.42408090
112Regulation of autophagy_Homo sapiens_hsa041400.42228874
113Olfactory transduction_Homo sapiens_hsa047400.42110724
114Taste transduction_Homo sapiens_hsa047420.41681219
115Hepatitis B_Homo sapiens_hsa051610.41436480
116Fatty acid degradation_Homo sapiens_hsa000710.39224760
117Nicotine addiction_Homo sapiens_hsa050330.38772828
118Thyroid cancer_Homo sapiens_hsa052160.38596258
119Apoptosis_Homo sapiens_hsa042100.37167033
120Arachidonic acid metabolism_Homo sapiens_hsa005900.34988939
121B cell receptor signaling pathway_Homo sapiens_hsa046620.34139455
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33743871
123Carbon metabolism_Homo sapiens_hsa012000.33343427
124Non-small cell lung cancer_Homo sapiens_hsa052230.33203991
125ECM-receptor interaction_Homo sapiens_hsa045120.33147792
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32997231
127Fatty acid metabolism_Homo sapiens_hsa012120.32286334
128N-Glycan biosynthesis_Homo sapiens_hsa005100.32231559
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32132139
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.31688703
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.31115300
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29900028
133Autoimmune thyroid disease_Homo sapiens_hsa053200.29544830
134Biosynthesis of amino acids_Homo sapiens_hsa012300.29333651
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28531479
136Selenocompound metabolism_Homo sapiens_hsa004500.28452890
137Malaria_Homo sapiens_hsa051440.27388280
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.27342009
139Measles_Homo sapiens_hsa051620.27184673
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26177431
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26010598
142Melanoma_Homo sapiens_hsa052180.24821629
143Endocytosis_Homo sapiens_hsa041440.24492635
144Chemical carcinogenesis_Homo sapiens_hsa052040.24149029
145Focal adhesion_Homo sapiens_hsa045100.24006134
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23435142
147Primary bile acid biosynthesis_Homo sapiens_hsa001200.22965333
148Arginine and proline metabolism_Homo sapiens_hsa003300.19768466
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.19187056
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18997820
151Ras signaling pathway_Homo sapiens_hsa040140.18863121
152Glycerolipid metabolism_Homo sapiens_hsa005610.18184466

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