TRIM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)5.99954211
2DNA deamination (GO:0045006)5.65861624
3proteasome assembly (GO:0043248)4.92668642
4regulation of nuclear cell cycle DNA replication (GO:0033262)4.72483080
5DNA replication checkpoint (GO:0000076)4.60664924
6somatic diversification of immune receptors via somatic mutation (GO:0002566)4.53822601
7regulation of meiosis I (GO:0060631)4.53149121
8ribosome biogenesis (GO:0042254)4.46225463
9synapsis (GO:0007129)4.41730388
10rRNA modification (GO:0000154)4.23967555
11mitotic metaphase plate congression (GO:0007080)4.23603051
12maturation of SSU-rRNA (GO:0030490)4.22244334
13DNA strand elongation involved in DNA replication (GO:0006271)4.21033033
14DNA replication initiation (GO:0006270)4.19243165
15ribonucleoprotein complex biogenesis (GO:0022613)4.17712963
16telomere maintenance via semi-conservative replication (GO:0032201)4.15652018
17nucleobase biosynthetic process (GO:0046112)4.13413176
18purine nucleobase biosynthetic process (GO:0009113)4.09579130
19ribosomal small subunit biogenesis (GO:0042274)4.03801479
20histone exchange (GO:0043486)3.99743961
21DNA strand elongation (GO:0022616)3.98049353
22histone H4-K12 acetylation (GO:0043983)3.97050652
23transcription elongation from RNA polymerase III promoter (GO:0006385)3.94134785
24termination of RNA polymerase III transcription (GO:0006386)3.94134785
25regulation of centriole replication (GO:0046599)3.92991463
26establishment of integrated proviral latency (GO:0075713)3.87644790
27ribosomal large subunit biogenesis (GO:0042273)3.86977677
28meiotic chromosome segregation (GO:0045132)3.84114983
29piRNA metabolic process (GO:0034587)3.79618557
30formation of translation preinitiation complex (GO:0001731)3.79547258
31mitochondrial DNA replication (GO:0006264)3.76444173
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67384231
33DNA damage response, detection of DNA damage (GO:0042769)3.67117008
34telomere maintenance via recombination (GO:0000722)3.66472813
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.66189510
36spliceosomal snRNP assembly (GO:0000387)3.63227604
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.63168510
38regulation of double-strand break repair via homologous recombination (GO:0010569)3.59970612
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59550196
40metaphase plate congression (GO:0051310)3.56918853
41rRNA processing (GO:0006364)3.56678358
42maturation of 5.8S rRNA (GO:0000460)3.56138876
43kinetochore assembly (GO:0051382)3.55435562
44regulation of DNA methylation (GO:0044030)3.54948062
45regulation of histone H3-K9 methylation (GO:0051570)3.54401898
46pseudouridine synthesis (GO:0001522)3.53978645
47deoxyribonucleotide biosynthetic process (GO:0009263)3.53646418
48telomere maintenance via telomere lengthening (GO:0010833)3.49541032
49positive regulation of histone H3-K4 methylation (GO:0051571)3.48855584
50DNA-dependent DNA replication (GO:0006261)3.47497802
51rRNA metabolic process (GO:0016072)3.46812252
52regulation of helicase activity (GO:0051095)3.46221272
53DNA replication-dependent nucleosome assembly (GO:0006335)3.46070360
54DNA replication-dependent nucleosome organization (GO:0034723)3.46070360
55DNA replication-independent nucleosome organization (GO:0034724)3.45224057
56DNA replication-independent nucleosome assembly (GO:0006336)3.45224057
57mitotic recombination (GO:0006312)3.41251633
587-methylguanosine mRNA capping (GO:0006370)3.40400859
59chromatin remodeling at centromere (GO:0031055)3.40064672
60CENP-A containing nucleosome assembly (GO:0034080)3.38929520
61protein-cofactor linkage (GO:0018065)3.37244675
62folic acid metabolic process (GO:0046655)3.36635959
63transcription-coupled nucleotide-excision repair (GO:0006283)3.36237504
64signal transduction involved in DNA integrity checkpoint (GO:0072401)3.35935987
65signal transduction involved in DNA damage checkpoint (GO:0072422)3.35935987
66regulation of posttranscriptional gene silencing (GO:0060147)3.35791320
67regulation of gene silencing by miRNA (GO:0060964)3.35791320
68regulation of gene silencing by RNA (GO:0060966)3.35791320
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34595695
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34595695
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34595695
72regulation of centrosome cycle (GO:0046605)3.34124748
73DNA strand renaturation (GO:0000733)3.33298480
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32515017
75DNA double-strand break processing (GO:0000729)3.31719923
76kinetochore organization (GO:0051383)3.31598303
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31425128
78negative regulation of ligase activity (GO:0051352)3.31425128
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.31404812
807-methylguanosine RNA capping (GO:0009452)3.31265620
81RNA capping (GO:0036260)3.31265620
82nucleotide transmembrane transport (GO:1901679)3.31263055
83RNA destabilization (GO:0050779)3.29797484
84transcription from RNA polymerase I promoter (GO:0006360)3.29050592
85protein localization to chromosome, centromeric region (GO:0071459)3.28275803
86IMP biosynthetic process (GO:0006188)3.27970105
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27000695
88mitotic sister chromatid segregation (GO:0000070)3.24470156
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.23480664
90RNA methylation (GO:0001510)3.23225418
91positive regulation of chromosome segregation (GO:0051984)3.22250334
92replication fork processing (GO:0031297)3.22018851
93meiotic cell cycle (GO:0051321)3.18573201
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.17195588
95regulation of cellular amino acid metabolic process (GO:0006521)3.16957902
96establishment of chromosome localization (GO:0051303)3.16154393
97DNA unwinding involved in DNA replication (GO:0006268)3.15785273
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14605060
99deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.14486251
100protein K6-linked ubiquitination (GO:0085020)3.14445464
101cell fate commitment involved in formation of primary germ layer (GO:0060795)3.13161966
102centriole replication (GO:0007099)3.12675641
103ribosomal small subunit assembly (GO:0000028)3.12154971
104mitochondrial DNA metabolic process (GO:0032042)3.11843275
105regulation of translational termination (GO:0006449)3.10920419
106protein localization to kinetochore (GO:0034501)3.10871016
107cellular component biogenesis (GO:0044085)3.10820227
108spliceosomal complex assembly (GO:0000245)3.10702743
109mitotic nuclear envelope disassembly (GO:0007077)3.10612142
110signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.10243853
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.10243853
112regulation of DNA endoreduplication (GO:0032875)3.10016484
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.09969702
114regulation of mitotic spindle checkpoint (GO:1903504)3.09969702
115negative regulation of mitotic sister chromatid separation (GO:2000816)3.09668144
116negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09668144
117negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09668144
118negative regulation of sister chromatid segregation (GO:0033046)3.09668144
119negative regulation of chromosome segregation (GO:0051985)3.09527036
120termination of RNA polymerase I transcription (GO:0006363)3.09410933
121nucleobase-containing small molecule interconversion (GO:0015949)3.09023405
122negative regulation of DNA-dependent DNA replication (GO:2000104)3.06683130
123rRNA methylation (GO:0031167)3.05800788
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05229157
125positive regulation of ligase activity (GO:0051351)3.05008894
126exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04721571
127spindle checkpoint (GO:0031577)3.04253954
128attachment of spindle microtubules to kinetochore (GO:0008608)3.04146694
129deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.03764055
130nucleotide-excision repair, DNA gap filling (GO:0006297)3.03647669
131folic acid-containing compound biosynthetic process (GO:0009396)3.03623309
132DNA catabolic process, exonucleolytic (GO:0000738)3.03250446
133somatic hypermutation of immunoglobulin genes (GO:0016446)3.02510526
134DNA methylation involved in gamete generation (GO:0043046)2.97806704
135mitotic G2/M transition checkpoint (GO:0044818)2.95636818
136telomere maintenance via telomerase (GO:0007004)2.91987564
137establishment of viral latency (GO:0019043)2.88238756
138heterochromatin organization (GO:0070828)2.87771819
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.86065568
140isotype switching (GO:0045190)2.86065568
141somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.86065568
142cullin deneddylation (GO:0010388)2.85244241
143sister chromatid segregation (GO:0000819)2.85209925
144regulation of telomere maintenance via telomerase (GO:0032210)2.84442583
145histone mRNA metabolic process (GO:0008334)2.83592865
146establishment of protein localization to mitochondrial membrane (GO:0090151)2.81611886
147rRNA catabolic process (GO:0016075)2.79404995
148ncRNA catabolic process (GO:0034661)2.79067981
149spindle assembly involved in mitosis (GO:0090307)2.77641051
150regulation of chromosome segregation (GO:0051983)2.77193415
151positive regulation of mitotic sister chromatid separation (GO:1901970)2.76417494
152positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76417494
153positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76417494
154protein localization to chromosome (GO:0034502)2.76016977
155lysine catabolic process (GO:0006554)2.71299092
156lysine metabolic process (GO:0006553)2.71299092
157maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71262412
158mitotic spindle checkpoint (GO:0071174)2.70622834
159mismatch repair (GO:0006298)2.70542417
160nuclear pore organization (GO:0006999)2.70481445
161male meiosis I (GO:0007141)2.70331642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.76662821
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.41282273
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69095205
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.40951288
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.40865446
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.32955436
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32540025
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.31781040
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30776739
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.26764767
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24909500
12SALL1_21062744_ChIP-ChIP_HESCs_Human3.24509901
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.06743258
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97125257
15ZNF274_21170338_ChIP-Seq_K562_Hela2.89327002
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87934128
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79833545
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65599407
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55949389
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49691229
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45715440
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40788039
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38269638
24VDR_23849224_ChIP-Seq_CD4+_Human2.36768288
25XRN2_22483619_ChIP-Seq_HELA_Human2.36171696
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.35819177
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17967588
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14047529
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11202731
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10867813
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04842615
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04842615
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04842615
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.00161857
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97751637
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96705347
37VDR_22108803_ChIP-Seq_LS180_Human1.92493111
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89903171
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88274485
40EWS_26573619_Chip-Seq_HEK293_Human1.87830660
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.87521408
42TTF2_22483619_ChIP-Seq_HELA_Human1.85366648
43FOXP3_21729870_ChIP-Seq_TREG_Human1.83825968
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82820816
45DCP1A_22483619_ChIP-Seq_HELA_Human1.81406185
46GABP_19822575_ChIP-Seq_HepG2_Human1.79504384
47AR_21909140_ChIP-Seq_LNCAP_Human1.72731492
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70982499
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70584030
50IRF1_19129219_ChIP-ChIP_H3396_Human1.70142996
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.69640461
52ELK1_19687146_ChIP-ChIP_HELA_Human1.68212013
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65704827
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60157369
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57222041
56* NANOG_16153702_ChIP-ChIP_HESCs_Human1.54683214
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.50473679
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50198493
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.49599350
60FUS_26573619_Chip-Seq_HEK293_Human1.48149222
61CIITA_25753668_ChIP-Seq_RAJI_Human1.47758381
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.45475464
63* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45167438
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.44944559
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43296553
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.42859600
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42082002
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39167873
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38514668
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37510362
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36267434
72KDM5A_27292631_Chip-Seq_BREAST_Human1.34211041
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32977410
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31379705
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29525545
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23533736
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23482231
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21937285
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21634572
80NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21599755
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19746529
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17598020
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16023338
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14481605
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14478054
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14294232
87P300_19829295_ChIP-Seq_ESCs_Human1.13904938
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.11540408
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.11297331
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10827131
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08546032
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07131444
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06830195
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06404978
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05865013
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05459534
97SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05092276
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05025467
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04406392
100GBX2_23144817_ChIP-Seq_PC3_Human1.03700282
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03209330
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02771668
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02598359
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02240312
105EZH2_22144423_ChIP-Seq_EOC_Human1.01704990
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00236593
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00203032
108TAF15_26573619_Chip-Seq_HEK293_Human0.99359607
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97548104
110TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93879401
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92879771
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91901049
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90564530
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89227841
115ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88037076
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87576431
117NANOG_18692474_ChIP-Seq_MEFs_Mouse0.86871488
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86559889
119SOX2_19829295_ChIP-Seq_ESCs_Human0.86521549
120NANOG_19829295_ChIP-Seq_ESCs_Human0.86521549
121TFEB_21752829_ChIP-Seq_HELA_Human0.86367280
122MYC_18940864_ChIP-ChIP_HL60_Human0.86326982
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86178406
124IGF1R_20145208_ChIP-Seq_DFB_Human0.85864420
125TP53_22573176_ChIP-Seq_HFKS_Human0.85693132
126FOXA1_25329375_ChIP-Seq_VCAP_Human0.85315289
127FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85315289
128NANOG_21062744_ChIP-ChIP_HESCs_Human0.84637850
129POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84450036
130RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83856840
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83767610
132SOX2_18692474_ChIP-Seq_MESCs_Mouse0.81484245
133* SOX17_20123909_ChIP-Seq_XEN_Mouse0.80481990
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80049622
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.79995471
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79843938
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76996165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.03313344
2MP0003111_abnormal_nucleus_morphology5.21586672
3MP0004957_abnormal_blastocyst_morpholog4.36114771
4MP0010094_abnormal_chromosome_stability4.23532183
5MP0002254_reproductive_system_inflammat4.20205951
6MP0003077_abnormal_cell_cycle4.06378542
7MP0008057_abnormal_DNA_replication4.04492725
8MP0008058_abnormal_DNA_repair3.78689219
9MP0008877_abnormal_DNA_methylation3.33099961
10MP0003718_maternal_effect3.09980103
11MP0008932_abnormal_embryonic_tissue2.95880721
12MP0008007_abnormal_cellular_replicative2.91663290
13MP0003950_abnormal_plasma_membrane2.88163326
14MP0003786_premature_aging2.72197414
15MP0003806_abnormal_nucleotide_metabolis2.32194524
16MP0001730_embryonic_growth_arrest2.25559507
17MP0002160_abnormal_reproductive_system2.24463563
18MP0010352_gastrointestinal_tract_polyps2.17041782
19MP0003123_paternal_imprinting2.07492256
20MP0003941_abnormal_skin_development2.04756179
21MP0004133_heterotaxia2.03244984
22MP0003315_abnormal_perineum_morphology1.94722097
23MP0000350_abnormal_cell_proliferation1.91713168
24MP0002102_abnormal_ear_morphology1.87228157
25MP0005389_reproductive_system_phenotype1.84490247
26MP0008789_abnormal_olfactory_epithelium1.77428492
27MP0002210_abnormal_sex_determination1.73042602
28MP0001672_abnormal_embryogenesis/_devel1.69840932
29MP0005380_embryogenesis_phenotype1.69840932
30MP0009697_abnormal_copulation1.62298752
31MP0001853_heart_inflammation1.61205119
32MP0001697_abnormal_embryo_size1.58990605
33MP0001145_abnormal_male_reproductive1.57743281
34MP0002085_abnormal_embryonic_tissue1.53799042
35MP0003890_abnormal_embryonic-extraembry1.49235013
36MP0000313_abnormal_cell_death1.48499516
37MP0002080_prenatal_lethality1.46574367
38MP0006072_abnormal_retinal_apoptosis1.41928977
39MP0003567_abnormal_fetal_cardiomyocyte1.39921839
40MP0003984_embryonic_growth_retardation1.37674647
41MP0006292_abnormal_olfactory_placode1.36515662
42MP0002088_abnormal_embryonic_growth/wei1.35379303
43MP0005394_taste/olfaction_phenotype1.35341649
44MP0005499_abnormal_olfactory_system1.35341649
45MP0003119_abnormal_digestive_system1.35175462
46MP0000653_abnormal_sex_gland1.31450737
47MP0003186_abnormal_redox_activity1.30912762
48MP0001929_abnormal_gametogenesis1.30650037
49MP0002938_white_spotting1.27593452
50MP0001919_abnormal_reproductive_system1.27573729
51MP0005395_other_phenotype1.23363570
52MP0002084_abnormal_developmental_patter1.21231616
53MP0010307_abnormal_tumor_latency1.21192555
54MP0002019_abnormal_tumor_incidence1.15598208
55MP0006035_abnormal_mitochondrial_morpho1.14395801
56MP0002086_abnormal_extraembryonic_tissu1.13929728
57MP0005551_abnormal_eye_electrophysiolog1.13357585
58MP0004197_abnormal_fetal_growth/weight/1.12292915
59MP0005377_hearing/vestibular/ear_phenot1.11934133
60MP0003878_abnormal_ear_physiology1.11934133
61MP0000631_abnormal_neuroendocrine_gland1.11659439
62MP0002837_dystrophic_cardiac_calcinosis1.11377243
63MP0002277_abnormal_respiratory_mucosa1.08329579
64MP0002111_abnormal_tail_morphology1.07640090
65MP0010030_abnormal_orbit_morphology1.06684252
66MP0002653_abnormal_ependyma_morphology1.03284212
67MP0000358_abnormal_cell_content/1.02469676
68MP0008260_abnormal_autophagy1.02060404
69MP0000647_abnormal_sebaceous_gland1.01214248
70MP0002233_abnormal_nose_morphology1.01061466
71MP0005384_cellular_phenotype1.00517287
72MP0000490_abnormal_crypts_of0.99794439
73MP0000427_abnormal_hair_cycle0.99065730
74MP0001346_abnormal_lacrimal_gland0.98094168
75MP0005621_abnormal_cell_physiology0.97996724
76MP0004147_increased_porphyrin_level0.96459805
77MP0001119_abnormal_female_reproductive0.96452394
78MP0002138_abnormal_hepatobiliary_system0.96352747
79MP0003936_abnormal_reproductive_system0.96001065
80MP0001293_anophthalmia0.95553718
81MP0005670_abnormal_white_adipose0.94618961
82MP0008995_early_reproductive_senescence0.93734631
83MP0000566_synostosis0.92992410
84MP0001529_abnormal_vocalization0.92467083
85MP0005410_abnormal_fertilization0.92390609
86MP0003937_abnormal_limbs/digits/tail_de0.89044097
87MP0000049_abnormal_middle_ear0.87483935
88MP0000383_abnormal_hair_follicle0.86637771
89MP0009840_abnormal_foam_cell0.85855871
90MP0005075_abnormal_melanosome_morpholog0.83814995
91MP0003698_abnormal_male_reproductive0.83699743
92MP0005084_abnormal_gallbladder_morpholo0.81487773
93MP0003195_calcinosis0.81261314
94MP0005174_abnormal_tail_pigmentation0.80035156
95MP0005266_abnormal_metabolism0.78861944
96MP0001286_abnormal_eye_development0.78293796
97MP0003943_abnormal_hepatobiliary_system0.75876865
98MP0004215_abnormal_myocardial_fiber0.75685485
99MP0003755_abnormal_palate_morphology0.74172206
100MP0008872_abnormal_physiological_respon0.73782547
101MP0000537_abnormal_urethra_morphology0.71286698
102MP0004019_abnormal_vitamin_homeostasis0.71075115
103MP0002876_abnormal_thyroid_physiology0.70356401
104MP0000858_altered_metastatic_potential0.70034325
105MP0005647_abnormal_sex_gland0.69308118
106MP0003121_genomic_imprinting0.68825875
107MP0002396_abnormal_hematopoietic_system0.68507842
108MP0000703_abnormal_thymus_morphology0.68389563
109MP0009672_abnormal_birth_weight0.67334965
110MP0000627_abnormal_mammary_gland0.65978484
111MP0000613_abnormal_salivary_gland0.65642981
112MP0001727_abnormal_embryo_implantation0.65309634
113MP0003861_abnormal_nervous_system0.64464406
114MP0002269_muscular_atrophy0.64276588
115MP0001984_abnormal_olfaction0.64085988
116MP0002736_abnormal_nociception_after0.63509469
117MP0003136_yellow_coat_color0.63343530
118MP0001485_abnormal_pinna_reflex0.63301447
119MP0002234_abnormal_pharynx_morphology0.63096108
120MP0005023_abnormal_wound_healing0.63007876
121MP0002161_abnormal_fertility/fecundity0.62078160
122MP0001986_abnormal_taste_sensitivity0.61926410
123MP0005253_abnormal_eye_physiology0.61810722
124MP0005197_abnormal_uvea_morphology0.61498928
125MP0003699_abnormal_female_reproductive0.60829419
126MP0009333_abnormal_splenocyte_physiolog0.60258933
127MP0000750_abnormal_muscle_regeneration0.60172400
128MP0005195_abnormal_posterior_eye0.59422166
129MP0000428_abnormal_craniofacial_morphol0.57566923
130MP0001188_hyperpigmentation0.57071363
131MP0002722_abnormal_immune_system0.56757664
132MP0006036_abnormal_mitochondrial_physio0.56669219
133MP0003646_muscle_fatigue0.56502988
134MP0009379_abnormal_foot_pigmentation0.55706916
135MP0003938_abnormal_ear_development0.53792263
136MP0001661_extended_life_span0.53692476
137MP0001186_pigmentation_phenotype0.53483679
138MP0003448_altered_tumor_morphology0.53138714
139MP0000689_abnormal_spleen_morphology0.52408637

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)5.85810297
2Progressive external ophthalmoplegia (HP:0000590)5.77744146
3Birth length less than 3rd percentile (HP:0003561)5.31599226
4Carpal bone hypoplasia (HP:0001498)4.39031600
5Cerebral hypomyelination (HP:0006808)3.97215563
6Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.91034283
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.81247222
8Absent radius (HP:0003974)3.65524277
9Chromsome breakage (HP:0040012)3.65199138
10Rough bone trabeculation (HP:0100670)3.58354441
11Progressive muscle weakness (HP:0003323)3.57786806
12Aplasia involving forearm bones (HP:0009822)3.45360488
13Absent forearm bone (HP:0003953)3.45360488
14Reticulocytopenia (HP:0001896)3.44304793
15Patellar aplasia (HP:0006443)3.32016010
16Abnormal lung lobation (HP:0002101)3.31840448
17Neoplasm of the adrenal cortex (HP:0100641)3.29205914
18Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.28685264
19Aplasia/Hypoplasia of the patella (HP:0006498)3.26514841
20External ophthalmoplegia (HP:0000544)3.22106747
21Oral leukoplakia (HP:0002745)3.21777022
22Meckel diverticulum (HP:0002245)3.21365237
23Granulocytopenia (HP:0001913)3.16236420
24Stomach cancer (HP:0012126)3.08348233
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.02105693
26Abnormality of the ileum (HP:0001549)3.02089534
27Proximal tubulopathy (HP:0000114)3.01323147
28Duplicated collecting system (HP:0000081)2.97958249
29Glioma (HP:0009733)2.97495452
30Aplasia/Hypoplasia of the earlobes (HP:0009906)2.97430674
31Impulsivity (HP:0100710)2.96989445
32Aplasia/Hypoplasia involving the musculature (HP:0001460)2.91611878
33Colon cancer (HP:0003003)2.89209388
34Neoplasm of the pancreas (HP:0002894)2.81649215
35Absent thumb (HP:0009777)2.80546277
36Supernumerary spleens (HP:0009799)2.78802984
37Pancreatic fibrosis (HP:0100732)2.75226330
38Abnormality of the preputium (HP:0100587)2.72858739
39Selective tooth agenesis (HP:0001592)2.72858340
40Pancreatic cysts (HP:0001737)2.71565698
41Macrocytic anemia (HP:0001972)2.70966087
42Pendular nystagmus (HP:0012043)2.69675000
43Agnosia (HP:0010524)2.66060096
44Abnormal trabecular bone morphology (HP:0100671)2.65582485
45Abnormality of chromosome stability (HP:0003220)2.62770107
46Aplasia/hypoplasia of the humerus (HP:0006507)2.61874027
47Methylmalonic acidemia (HP:0002912)2.60446473
48Trismus (HP:0000211)2.58360423
49Premature ovarian failure (HP:0008209)2.56913354
50Ependymoma (HP:0002888)2.56384313
51Ectopic kidney (HP:0000086)2.55664261
52Premature graying of hair (HP:0002216)2.54278298
53Abnormality of the renal collecting system (HP:0004742)2.50924508
54Microretrognathia (HP:0000308)2.50552195
55Brushfield spots (HP:0001088)2.50211774
56Horseshoe kidney (HP:0000085)2.49404576
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.47251396
58Medulloblastoma (HP:0002885)2.43028085
59Degeneration of anterior horn cells (HP:0002398)2.41263772
60Abnormality of the anterior horn cell (HP:0006802)2.41263772
61Bone marrow hypocellularity (HP:0005528)2.40262527
62True hermaphroditism (HP:0010459)2.39772574
63Short tibia (HP:0005736)2.38908900
64Abnormality of the duodenum (HP:0002246)2.38885271
65Secondary amenorrhea (HP:0000869)2.38877389
66Abnormality of midbrain morphology (HP:0002418)2.38667372
67Molar tooth sign on MRI (HP:0002419)2.38667372
68Nephroblastoma (Wilms tumor) (HP:0002667)2.29928860
69Abnormality of the labia minora (HP:0012880)2.29902884
70Abnormal spermatogenesis (HP:0008669)2.29875766
71Breast aplasia (HP:0100783)2.28681241
72Homocystinuria (HP:0002156)2.28357054
73Abnormality of homocysteine metabolism (HP:0010919)2.28357054
74Bilateral microphthalmos (HP:0007633)2.28114435
75Abnormality of methionine metabolism (HP:0010901)2.28049545
76Megaloblastic anemia (HP:0001889)2.27902090
77Abnormality of the pons (HP:0007361)2.27448107
78CNS hypomyelination (HP:0003429)2.27214800
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.26313586
80Abnormality of cells of the erythroid lineage (HP:0012130)2.26285882
81Cellular immunodeficiency (HP:0005374)2.26251961
82Volvulus (HP:0002580)2.25929693
83Increased serum lactate (HP:0002151)2.25804381
84Abnormal number of erythroid precursors (HP:0012131)2.25716510
85Septo-optic dysplasia (HP:0100842)2.24331475
86Embryonal renal neoplasm (HP:0011794)2.23315096
87Hyperalaninemia (HP:0003348)2.23282309
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23282309
89Abnormality of alanine metabolism (HP:0010916)2.23282309
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22032126
91Median cleft lip (HP:0000161)2.18306645
92Hyperglycinemia (HP:0002154)2.16916945
93Ureteral duplication (HP:0000073)2.16854405
94Triphalangeal thumb (HP:0001199)2.16773191
95Sloping forehead (HP:0000340)2.15859675
96Aplasia/Hypoplasia of the breasts (HP:0010311)2.15126403
97Atrophy/Degeneration involving motor neurons (HP:0007373)2.13374740
98Microvesicular hepatic steatosis (HP:0001414)2.13204705
99Abnormality of abdominal situs (HP:0011620)2.13061902
100Abdominal situs inversus (HP:0003363)2.13061902
101Glucose intolerance (HP:0000833)2.12738882
102Breech presentation (HP:0001623)2.12690972
103Osteomalacia (HP:0002749)2.11605416
104Aplastic anemia (HP:0001915)2.10149255
105Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08979879
106Aplasia/Hypoplasia of the spleen (HP:0010451)2.08466952
107Aplasia/Hypoplasia of the tongue (HP:0010295)2.08002849
108Cleft eyelid (HP:0000625)2.07320698
109Abnormal biliary tract physiology (HP:0012439)2.06312615
110Bile duct proliferation (HP:0001408)2.06312615
111Hyperglycinuria (HP:0003108)2.05738573
112Aplasia/hypoplasia of the uterus (HP:0008684)2.04387787
113Female pseudohermaphroditism (HP:0010458)2.03345173
114Absent septum pellucidum (HP:0001331)2.02370466
115Tracheoesophageal fistula (HP:0002575)2.02040758
116Hypoplasia of the pons (HP:0012110)2.01412427
117Duodenal stenosis (HP:0100867)2.00770465
118Small intestinal stenosis (HP:0012848)2.00770465
119Abnormality of pyrimidine metabolism (HP:0004353)2.00645067
120Neoplasm of the colon (HP:0100273)2.00325997
121Aplasia/Hypoplasia of the fovea (HP:0008060)1.99141696
122Hypoplasia of the fovea (HP:0007750)1.99141696
123Rhabdomyosarcoma (HP:0002859)1.98495100
124Neoplasm of the oral cavity (HP:0100649)1.98110896
1253-Methylglutaconic aciduria (HP:0003535)1.98062284
126Testicular atrophy (HP:0000029)1.97667116
127Stenosis of the external auditory canal (HP:0000402)1.96123693
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95649154
129Pallor (HP:0000980)1.95526778
130Clubbing of toes (HP:0100760)1.95332938
131Methylmalonic aciduria (HP:0012120)1.94450753
132Sparse eyelashes (HP:0000653)1.93803697
133Astrocytoma (HP:0009592)1.93602907
134Abnormality of the astrocytes (HP:0100707)1.93602907
135Absent hand (HP:0004050)1.91536501
136Fused cervical vertebrae (HP:0002949)1.90380780
137Abnormality of sulfur amino acid metabolism (HP:0004339)1.89883702
138Abnormality of the septum pellucidum (HP:0007375)1.88902778
139Increased CSF lactate (HP:0002490)1.86968109
140Abnormality of glycine metabolism (HP:0010895)1.86509471
141Abnormality of serine family amino acid metabolism (HP:0010894)1.86509471
142Asplenia (HP:0001746)1.86188901
143Unsteady gait (HP:0002317)1.85508647
144Preaxial hand polydactyly (HP:0001177)1.85404672
145Acute lymphatic leukemia (HP:0006721)1.85230700
146Small hand (HP:0200055)1.84987103
147Facial cleft (HP:0002006)1.84969348
148Gonadotropin excess (HP:0000837)1.83938640
149Poor head control (HP:0002421)1.83327132
15011 pairs of ribs (HP:0000878)1.83171923
151Progressive inability to walk (HP:0002505)1.82784399
152Multiple enchondromatosis (HP:0005701)1.82534359
153Abnormality of serum amino acid levels (HP:0003112)1.82520426
154Medial flaring of the eyebrow (HP:0010747)1.81843333
155Prolonged neonatal jaundice (HP:0006579)1.81626450
156Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81074673
157Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81074673
158Supernumerary bones of the axial skeleton (HP:0009144)1.80474518
159Azoospermia (HP:0000027)1.80369393
160Abolished electroretinogram (ERG) (HP:0000550)1.80224425
161Optic nerve hypoplasia (HP:0000609)1.79664495
162Acute necrotizing encephalopathy (HP:0006965)1.79553693
163Dandy-Walker malformation (HP:0001305)1.77726048
164Bifid tongue (HP:0010297)1.77724274
165Genital tract atresia (HP:0001827)1.77715129
166Nephronophthisis (HP:0000090)1.75160424
167Abnormality of the carotid arteries (HP:0005344)1.73549761
168Acute encephalopathy (HP:0006846)1.73087310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.84142414
2PLK45.46491570
3BUB15.29090506
4MARK14.04901633
5ZAK3.98621348
6WEE13.65226027
7STK163.43011934
8VRK22.82891175
9EPHA22.78646927
10TTK2.73403710
11MST42.56444324
12IRAK42.54719523
13IRAK22.38598322
14BMPR1B2.36399942
15PNCK2.25660623
16SRPK12.23378906
17TSSK62.22157372
18NUAK12.18652757
19EIF2AK12.15830969
20TRIM281.98893041
21IRAK11.92951261
22TESK21.92864190
23CDC71.90233585
24CDK191.82485827
25TNIK1.69523177
26PLK11.60003450
27WNK31.52477103
28PLK31.51960678
29TAF11.48971809
30EIF2AK31.45621502
31TGFBR11.45540203
32INSRR1.44184332
33NEK11.41954625
34RPS6KB21.39636050
35AKT31.34656444
36STK31.33122553
37OXSR11.29524508
38ADRBK21.26207290
39DYRK31.25791422
40ATR1.24617042
41STK38L1.19475447
42NEK21.17900246
43GRK11.14767500
44PAK41.14018172
45CHEK21.13713832
46LATS21.13399140
47TLK11.11958327
48PRKCI1.11876285
49VRK11.10207786
50WNK41.07825133
51MET1.06769983
52KDR1.02375467
53TIE10.94319084
54ERBB40.94113549
55AURKA0.93819338
56BRSK20.92135992
57AURKB0.92022811
58ACVR1B0.90635447
59CDK80.89755574
60CDK70.82031773
61CHEK10.80900207
62STK390.78260153
63MAPKAPK30.77560586
64MAP4K20.77051712
65MAP3K130.75955053
66MAP3K80.72821073
67TESK10.71690345
68PBK0.66684452
69MKNK10.66471539
70FLT30.65806493
71CLK10.65534512
72NME10.65142710
73FRK0.64823777
74CDK90.64202313
75STK40.61671177
76BRAF0.61121310
77CSNK1G10.60102459
78DYRK20.60026978
79BRSK10.59515035
80BRD40.59120123
81EIF2AK20.56398759
82ATM0.56047598
83PASK0.53838267
84ABL20.53610942
85BCKDK0.53371097
86CDK20.50334073
87PAK10.50217205
88BCR0.47846678
89MKNK20.47432326
90SCYL20.47197496
91STK240.47024694
92MAP3K110.46828350
93MAP3K40.45951673
94MAPK70.42956095
95CSNK2A10.42649920
96PRKCE0.41387231
97CSNK2A20.41299310
98CDC42BPA0.40387317
99NEK90.40144992
100CDK120.39950700
101FGFR10.38072748
102CDK10.37997946
103STK100.37440790
104CSNK1G30.37371648
105MAPKAPK50.36208777
106CSNK1E0.35864896
107MAP3K90.35773907
108CSNK1G20.31327809
109RPS6KA40.31192266
110RPS6KA50.30059502
111CAMK2B0.28979866
112MAP3K120.27595615
113CAMK2G0.27551572
114CSNK1A1L0.27010032
115CDK30.26969728
116CDK40.25670743
117NME20.25497806
118PIM20.25419121
119ALK0.24227327
120PINK10.23942284
121PRKDC0.23124723
122FGR0.22998218
123CAMK1G0.22567327
124PRKCG0.22467488
125ADRBK10.22349497
126CAMK2D0.22012645
127PIM10.21641123
128LIMK10.21357864
129PDK20.20416292
130ARAF0.20344241
131CCNB10.19436790
132PLK20.18988287
133MAPK40.17807303
134BLK0.14409934
135NEK60.13250273
136IKBKB0.12470643
137MAP2K20.09443042
138STK380.08819627
139MAPK100.08197119
140MAPK90.07737552
141PDK40.06780389
142PDK30.06780389
143GSK3B0.06242370
144LATS10.06030363
145MAPK140.05415179
146MELK0.04809971

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.47867491
2DNA replication_Homo sapiens_hsa030304.47771309
3RNA polymerase_Homo sapiens_hsa030204.23850973
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.09283362
5Mismatch repair_Homo sapiens_hsa034304.01424200
6Ribosome_Homo sapiens_hsa030103.56348196
7Spliceosome_Homo sapiens_hsa030403.26233633
8RNA transport_Homo sapiens_hsa030132.97204700
9Pyrimidine metabolism_Homo sapiens_hsa002402.86143838
10Homologous recombination_Homo sapiens_hsa034402.83170253
11Fanconi anemia pathway_Homo sapiens_hsa034602.82434153
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.65027570
13One carbon pool by folate_Homo sapiens_hsa006702.64469059
14Nucleotide excision repair_Homo sapiens_hsa034202.56377401
15Base excision repair_Homo sapiens_hsa034102.54125651
16Cell cycle_Homo sapiens_hsa041102.25169459
17Basal transcription factors_Homo sapiens_hsa030221.95566544
18RNA degradation_Homo sapiens_hsa030181.78396394
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76495675
20p53 signaling pathway_Homo sapiens_hsa041151.75760479
21Purine metabolism_Homo sapiens_hsa002301.59265357
22Propanoate metabolism_Homo sapiens_hsa006401.56451347
23Non-homologous end-joining_Homo sapiens_hsa034501.51572166
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40222231
25Epstein-Barr virus infection_Homo sapiens_hsa051691.38503829
26Vitamin B6 metabolism_Homo sapiens_hsa007501.36458720
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28651521
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.25744844
29mRNA surveillance pathway_Homo sapiens_hsa030151.23160509
30Steroid biosynthesis_Homo sapiens_hsa001001.22950796
31Huntingtons disease_Homo sapiens_hsa050161.20348819
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19394247
33Pyruvate metabolism_Homo sapiens_hsa006201.14082006
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11584260
35Phototransduction_Homo sapiens_hsa047441.10672426
36Pentose phosphate pathway_Homo sapiens_hsa000301.09609310
37Caffeine metabolism_Homo sapiens_hsa002321.09069081
38Folate biosynthesis_Homo sapiens_hsa007901.07856093
39Oxidative phosphorylation_Homo sapiens_hsa001901.07334439
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06363661
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06011100
42Glutathione metabolism_Homo sapiens_hsa004801.03531740
43Parkinsons disease_Homo sapiens_hsa050120.95062374
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92809017
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92198584
46Fatty acid elongation_Homo sapiens_hsa000620.89986915
47Biosynthesis of amino acids_Homo sapiens_hsa012300.89418902
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88506612
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.88059084
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81498001
51Oocyte meiosis_Homo sapiens_hsa041140.81377170
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.79168404
53Butanoate metabolism_Homo sapiens_hsa006500.74562249
54Peroxisome_Homo sapiens_hsa041460.71829557
55Systemic lupus erythematosus_Homo sapiens_hsa053220.69086319
56Fructose and mannose metabolism_Homo sapiens_hsa000510.68840529
57Selenocompound metabolism_Homo sapiens_hsa004500.68007196
58Viral carcinogenesis_Homo sapiens_hsa052030.62160431
59Regulation of autophagy_Homo sapiens_hsa041400.61854099
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59767988
61Carbon metabolism_Homo sapiens_hsa012000.55133880
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54244979
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53120023
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51966977
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51740797
66Arachidonic acid metabolism_Homo sapiens_hsa005900.51405596
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51245576
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51169847
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51033130
70Metabolic pathways_Homo sapiens_hsa011000.49845600
71Arginine and proline metabolism_Homo sapiens_hsa003300.48283327
72Cardiac muscle contraction_Homo sapiens_hsa042600.48139606
73Herpes simplex infection_Homo sapiens_hsa051680.48081359
74Ether lipid metabolism_Homo sapiens_hsa005650.47083902
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46187103
76Nitrogen metabolism_Homo sapiens_hsa009100.44939872
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44514920
78HTLV-I infection_Homo sapiens_hsa051660.43506380
79Tryptophan metabolism_Homo sapiens_hsa003800.42728826
80Antigen processing and presentation_Homo sapiens_hsa046120.41518710
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40273562
82Protein export_Homo sapiens_hsa030600.38693421
83Nicotine addiction_Homo sapiens_hsa050330.38496793
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38099633
85Alzheimers disease_Homo sapiens_hsa050100.37368449
86Galactose metabolism_Homo sapiens_hsa000520.36204814
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35416002
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.34726825
89Sulfur relay system_Homo sapiens_hsa041220.34353419
90Chemical carcinogenesis_Homo sapiens_hsa052040.32590637
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.31670673
92Lysine degradation_Homo sapiens_hsa003100.31277031
93Hippo signaling pathway_Homo sapiens_hsa043900.31148249
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30641978
95Other glycan degradation_Homo sapiens_hsa005110.30542985
96Linoleic acid metabolism_Homo sapiens_hsa005910.30422291
97Sulfur metabolism_Homo sapiens_hsa009200.29637635
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28683357
99Olfactory transduction_Homo sapiens_hsa047400.28158877
100Wnt signaling pathway_Homo sapiens_hsa043100.26553683
101Phenylalanine metabolism_Homo sapiens_hsa003600.26081690
102Taste transduction_Homo sapiens_hsa047420.23488709
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23041237
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22542746
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.21703346
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20745968
107N-Glycan biosynthesis_Homo sapiens_hsa005100.19581194
108Tight junction_Homo sapiens_hsa045300.18454715
109Adherens junction_Homo sapiens_hsa045200.18361128
110Hedgehog signaling pathway_Homo sapiens_hsa043400.18274756
111Dorso-ventral axis formation_Homo sapiens_hsa043200.17428531
112Renin-angiotensin system_Homo sapiens_hsa046140.14542475
113Shigellosis_Homo sapiens_hsa051310.13965514
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.13890933
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12839786
116Apoptosis_Homo sapiens_hsa042100.12204356
117Legionellosis_Homo sapiens_hsa051340.12012036
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11618557
119MicroRNAs in cancer_Homo sapiens_hsa052060.11142290
120Basal cell carcinoma_Homo sapiens_hsa052170.11013618
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10797336
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10785100
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10134483
124Thyroid cancer_Homo sapiens_hsa052160.10120019
125Vitamin digestion and absorption_Homo sapiens_hsa049770.10034809
126Retinol metabolism_Homo sapiens_hsa008300.09808113
127TGF-beta signaling pathway_Homo sapiens_hsa043500.09630226
128Sphingolipid metabolism_Homo sapiens_hsa006000.09383331
129Tyrosine metabolism_Homo sapiens_hsa003500.08746459
130HIF-1 signaling pathway_Homo sapiens_hsa040660.08304539
131Small cell lung cancer_Homo sapiens_hsa052220.08022814
132beta-Alanine metabolism_Homo sapiens_hsa004100.07228391
133Notch signaling pathway_Homo sapiens_hsa043300.05022118
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.04821408
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.03029089

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