TRIM60

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.43999412
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.37560459
3regulation of meiosis (GO:0040020)6.27183944
4female gamete generation (GO:0007292)6.10326451
5mitotic metaphase plate congression (GO:0007080)6.08938173
6regulation of meiosis I (GO:0060631)5.97783749
7meiosis I (GO:0007127)5.92077291
8regulation of female gonad development (GO:2000194)5.91243944
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.76246030
10mitotic chromosome condensation (GO:0007076)5.65019437
11regulation of exit from mitosis (GO:0007096)5.58475973
12negative regulation of hormone metabolic process (GO:0032351)5.54497401
13negative regulation of hormone biosynthetic process (GO:0032353)5.54497401
14meiotic cell cycle (GO:0051321)5.38258775
15regulation of DNA methylation (GO:0044030)5.36517236
16oocyte maturation (GO:0001556)5.25742456
17negative regulation of meiosis (GO:0045835)5.25532599
18histone H2A monoubiquitination (GO:0035518)5.19792879
19metaphase plate congression (GO:0051310)5.08094996
20regulation of retinoic acid receptor signaling pathway (GO:0048385)4.96221600
21DNA damage induced protein phosphorylation (GO:0006975)4.95183182
22regulation of meiotic cell cycle (GO:0051445)4.95144084
23male meiosis (GO:0007140)4.94984216
24mitotic sister chromatid segregation (GO:0000070)4.92563866
25regulation of sister chromatid cohesion (GO:0007063)4.89017543
26glycerophospholipid catabolic process (GO:0046475)4.82982025
27establishment of chromosome localization (GO:0051303)4.81169493
28synapsis (GO:0007129)4.76524987
29DNA methylation involved in gamete generation (GO:0043046)4.74804579
30DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.62742394
31attachment of spindle microtubules to kinetochore (GO:0008608)4.61020036
32maturation of 5.8S rRNA (GO:0000460)4.60298237
33positive regulation of meiotic cell cycle (GO:0051446)4.54813486
34regulation of RIG-I signaling pathway (GO:0039535)4.50604945
35DNA damage response, signal transduction resulting in transcription (GO:0042772)4.50142614
36regulation of histone H3-K27 methylation (GO:0061085)4.50139899
37female gonad development (GO:0008585)4.42293345
38regulation of glucocorticoid metabolic process (GO:0031943)4.41618730
39meiotic chromosome segregation (GO:0045132)4.39138484
40histone H2A ubiquitination (GO:0033522)4.35491386
41negative regulation of smooth muscle cell differentiation (GO:0051151)4.29740255
42monoubiquitinated protein deubiquitination (GO:0035520)4.29151254
43type B pancreatic cell development (GO:0003323)4.27942698
44negative regulation of mast cell activation (GO:0033004)4.21086330
45positive regulation of protein homooligomerization (GO:0032464)4.02268607
46retinal cone cell development (GO:0046549)4.01375585
47regulation of transforming growth factor beta2 production (GO:0032909)3.97867987
48sister chromatid segregation (GO:0000819)3.96876758
49multicellular organism reproduction (GO:0032504)3.96666031
50meiotic cell cycle process (GO:1903046)3.93151238
51negative regulation of DNA-templated transcription, elongation (GO:0032785)3.89471669
52negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.89471669
53regulation of spindle organization (GO:0090224)3.88859137
54chromosome organization involved in meiosis (GO:0070192)3.86678432
55positive regulation of megakaryocyte differentiation (GO:0045654)3.85201607
56positive regulation of DNA-dependent DNA replication (GO:2000105)3.79738267
57DNA methylation (GO:0006306)3.79309542
58DNA alkylation (GO:0006305)3.79309542
59chromosome segregation (GO:0007059)3.75648615
60regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.75542301
61microtubule severing (GO:0051013)3.73057539
62mitotic sister chromatid cohesion (GO:0007064)3.72443599
63transcription from mitochondrial promoter (GO:0006390)3.69334756
64protein localization to chromosome, centromeric region (GO:0071459)3.67141847
65protein localization to chromosome (GO:0034502)3.65902088
66gene silencing by RNA (GO:0031047)3.65696401
67rRNA modification (GO:0000154)3.62409574
68regulation of mitotic spindle organization (GO:0060236)3.60871525
69negative regulation of meiotic cell cycle (GO:0051447)3.54015516
70regulation of chromosome segregation (GO:0051983)3.49586593
71protein localization to kinetochore (GO:0034501)3.49225718
72positive regulation of chromosome segregation (GO:0051984)3.48852638
73microtubule nucleation (GO:0007020)3.47087228
74notochord development (GO:0030903)3.45695572
75regulation of mononuclear cell migration (GO:0071675)3.44833470
76snRNA transcription (GO:0009301)3.43419876
77negative regulation of alcohol biosynthetic process (GO:1902931)3.43282561
78spindle checkpoint (GO:0031577)3.41416692
79regulation of cell maturation (GO:1903429)3.41076836
80negative regulation of reproductive process (GO:2000242)3.39936569
81mitotic nuclear envelope disassembly (GO:0007077)3.39712470
82regulation of steroid hormone biosynthetic process (GO:0090030)3.38544558
83oogenesis (GO:0048477)3.37865274
84cytoplasmic mRNA processing body assembly (GO:0033962)3.37373301
85protein K6-linked ubiquitination (GO:0085020)3.37192392
86CENP-A containing nucleosome assembly (GO:0034080)3.35194347
87negative regulation of circadian rhythm (GO:0042754)3.30754817
88parturition (GO:0007567)3.29798411
89regulation of acrosome reaction (GO:0060046)3.28752343
90DNA replication-independent nucleosome organization (GO:0034724)3.28338390
91DNA replication-independent nucleosome assembly (GO:0006336)3.28338390
92pseudouridine synthesis (GO:0001522)3.23188011
93nuclear envelope disassembly (GO:0051081)3.22986622
94membrane disassembly (GO:0030397)3.22986622
95kinetochore assembly (GO:0051382)3.22041748
96synaptonemal complex organization (GO:0070193)3.21456554
97meiotic nuclear division (GO:0007126)3.20649025
98chromatin remodeling at centromere (GO:0031055)3.19355459
99rRNA methylation (GO:0031167)3.18428559
100sister chromatid cohesion (GO:0007062)3.18077210
101centriole replication (GO:0007099)3.15127869
102positive regulation of mitotic sister chromatid separation (GO:1901970)3.14819077
103positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14819077
104positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14819077
105somite rostral/caudal axis specification (GO:0032525)3.14392239
106positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.14293215
107negative regulation of cell division (GO:0051782)3.13276329
108N-terminal protein amino acid acetylation (GO:0006474)3.11681169
109histone exchange (GO:0043486)3.11336390
110intra-S DNA damage checkpoint (GO:0031573)3.11076786
111DNA replication checkpoint (GO:0000076)3.09925146
112synaptonemal complex assembly (GO:0007130)3.07252588
113proteasome assembly (GO:0043248)3.06111887
114protein-cofactor linkage (GO:0018065)3.05303778
115myoblast migration (GO:0051451)3.04302205
116positive regulation of meiosis (GO:0045836)3.04105781
117negative regulation of nuclear division (GO:0051784)3.03313165
118kinetochore organization (GO:0051383)3.03291518
119positive regulation of histone H3-K4 methylation (GO:0051571)3.02648980
120RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02037652
121mitotic spindle checkpoint (GO:0071174)3.00863387
122male meiosis I (GO:0007141)3.00424484
123negative regulation of cAMP-mediated signaling (GO:0043951)2.99326956
124DNA deamination (GO:0045006)2.98559387
125regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97526737
126reciprocal meiotic recombination (GO:0007131)2.92639737
127reciprocal DNA recombination (GO:0035825)2.92639737
128gonadal mesoderm development (GO:0007506)2.91816076
129positive regulation of cAMP-mediated signaling (GO:0043950)2.91121522
130peptidyl-histidine modification (GO:0018202)2.89902987
131mitochondrial respiratory chain complex I assembly (GO:0032981)2.89572248
132NADH dehydrogenase complex assembly (GO:0010257)2.89572248
133mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89572248
134transcription elongation from RNA polymerase I promoter (GO:0006362)2.86453622
135oocyte development (GO:0048599)2.85168895
136resolution of meiotic recombination intermediates (GO:0000712)2.68955179
137mitochondrial RNA metabolic process (GO:0000959)2.66332422
138centriole assembly (GO:0098534)2.64115366
139glycine transport (GO:0015816)2.62215674
140exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62197968
141nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61364785
142fertilization (GO:0009566)2.59996450
143regulation of double-strand break repair via homologous recombination (GO:0010569)2.56395418
144transcription elongation from RNA polymerase III promoter (GO:0006385)2.55967603
145termination of RNA polymerase III transcription (GO:0006386)2.55967603
146DNA replication-dependent nucleosome assembly (GO:0006335)2.54993786
147DNA replication-dependent nucleosome organization (GO:0034723)2.54993786
148positive regulation of gastrulation (GO:2000543)2.54987875
149histone mRNA metabolic process (GO:0008334)2.54729479
150termination of RNA polymerase I transcription (GO:0006363)2.53954530
151negative regulation of epidermal cell differentiation (GO:0045605)2.53263161
152chaperone-mediated protein transport (GO:0072321)2.52529370
153response to UV-C (GO:0010225)2.50687049
154spindle assembly involved in mitosis (GO:0090307)2.50416671
155platelet dense granule organization (GO:0060155)2.49304059
156primitive streak formation (GO:0090009)2.49207276
157DNA methylation or demethylation (GO:0044728)2.48406879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.74177334
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.57324036
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.83813552
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.80455400
5* KAP1_22055183_ChIP-Seq_ESCs_Mouse3.71327440
6ZNF274_21170338_ChIP-Seq_K562_Hela3.62981102
7E2F7_22180533_ChIP-Seq_HELA_Human3.55517563
8NOTCH1_21737748_ChIP-Seq_TLL_Human3.52877397
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.49461956
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35008974
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.22481463
12AR_21909140_ChIP-Seq_LNCAP_Human3.21351594
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.00765297
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.98556458
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.89572656
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.51263592
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.50598031
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.46372734
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.46372734
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.46372734
21VDR_22108803_ChIP-Seq_LS180_Human2.41922761
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.40252799
23IGF1R_20145208_ChIP-Seq_DFB_Human2.35825227
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32330596
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12456269
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07850025
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.07681151
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07212285
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.06519208
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04267278
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02918251
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95479319
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89519009
34TP53_22573176_ChIP-Seq_HFKS_Human1.84789404
35LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84658122
36IRF1_19129219_ChIP-ChIP_H3396_Human1.80632281
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78542530
38VDR_23849224_ChIP-Seq_CD4+_Human1.75575237
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71867560
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71269432
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70990386
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69453973
43MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69266571
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67835987
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67504243
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66744644
47RUNX1_26923725_Chip-Seq_HPCs_Mouse1.65329759
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64644863
49GBX2_23144817_ChIP-Seq_PC3_Human1.64304781
50TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.58441047
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.58304579
52RNF2_27304074_Chip-Seq_NSC_Mouse1.56949053
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.55488301
54FOXP3_21729870_ChIP-Seq_TREG_Human1.52882980
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52445860
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.51174839
57ELK1_19687146_ChIP-ChIP_HELA_Human1.50844477
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49448093
59FUS_26573619_Chip-Seq_HEK293_Human1.47336263
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46576200
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45327099
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44965482
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.44101418
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38505217
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38138586
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.36369896
67STAT3_23295773_ChIP-Seq_U87_Human1.34057201
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34030307
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33772832
70MYC_18940864_ChIP-ChIP_HL60_Human1.33745725
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33313615
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32381460
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32237719
74STAT1_17558387_ChIP-Seq_HELA_Human1.31993240
75CDX2_22108803_ChIP-Seq_LS180_Human1.31265451
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28148873
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27565335
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27231298
79HOXB7_26014856_ChIP-Seq_BT474_Human1.26303179
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24113819
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24113819
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23027835
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22594573
84CBP_20019798_ChIP-Seq_JUKART_Human1.22068887
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22068887
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21995130
87HTT_18923047_ChIP-ChIP_STHdh_Human1.21261185
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20303525
89P300_19829295_ChIP-Seq_ESCs_Human1.19174026
90ELK4_26923725_Chip-Seq_MESODERM_Mouse1.17986375
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17804643
92BCAT_22108803_ChIP-Seq_LS180_Human1.17431306
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.17217613
94NFYA_21822215_ChIP-Seq_K562_Human1.15165177
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14629780
96AR_21572438_ChIP-Seq_LNCaP_Human1.14032525
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.13960947
98TCF4_23295773_ChIP-Seq_U87_Human1.12494770
99NANOG_19829295_ChIP-Seq_ESCs_Human1.12383991
100SOX2_19829295_ChIP-Seq_ESCs_Human1.12383991
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12252692
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.12252692
103NCOR_22424771_ChIP-Seq_293T_Human1.11977823
104EWS_26573619_Chip-Seq_HEK293_Human1.11065307
105GATA3_21878914_ChIP-Seq_MCF-7_Human1.10595881
106TBL1_22424771_ChIP-Seq_293T_Human1.09626824
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.08850716
108SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08345324
109YY1_21170310_ChIP-Seq_MESCs_Mouse1.08342276
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08217016
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07809954
112FOXH1_21741376_ChIP-Seq_EPCs_Human1.07806924
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07470469
114GABP_19822575_ChIP-Seq_HepG2_Human1.07450659
115AR_20517297_ChIP-Seq_VCAP_Human1.06191767
116KDM2B_26808549_Chip-Seq_REH_Human1.05894343
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.04146116
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04066105
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03429565
120ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03407550
121EZH2_22144423_ChIP-Seq_EOC_Human1.03270099
122TAF15_26573619_Chip-Seq_HEK293_Human1.02718150
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02606976
124NANOG_20526341_ChIP-Seq_ESCs_Human1.01563245
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01039248
126CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00962787
127GATA3_21867929_ChIP-Seq_TH1_Mouse1.00824378
128ETV1_20927104_ChIP-Seq_GIST48_Human1.00504834
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99955020
130TCF4_22108803_ChIP-Seq_LS180_Human0.98538512
131CTCF_18555785_Chip-Seq_ESCs_Mouse0.97931466
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.97887454
133KLF4_18555785_Chip-Seq_ESCs_Mouse0.97743251
134SOX2_18555785_Chip-Seq_ESCs_Mouse0.97596571
135PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97120639
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96836737
137ERA_21632823_ChIP-Seq_H3396_Human0.95834997
138NMYC_18555785_Chip-Seq_ESCs_Mouse0.95341366
139FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95172883
140ERG_20517297_ChIP-Seq_VCAP_Human0.94403477
141MYC_19829295_ChIP-Seq_ESCs_Human0.94004491
142EP300_21415370_ChIP-Seq_HL-1_Mouse0.93530775
143EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92795134
144ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92596840
145CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92171146
146CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91825464
147KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91646008
148ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91478794
149EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91220879
150SMAD4_21799915_ChIP-Seq_A2780_Human0.91122900
151HNFA_21074721_ChIP-Seq_CACO-2_Human0.90343805
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90071664
153PHF8_20622853_ChIP-Seq_HELA_Human0.89980394
154RBPJ_21746931_ChIP-Seq_IB4_Human0.89768854
155CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88753639
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.88563835
157FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88409649
158GATA3_26560356_Chip-Seq_TH2_Human0.87780262
159OCT4_18555785_Chip-Seq_ESCs_Mouse0.87722294
160TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86934333
161GF1B_26923725_Chip-Seq_HPCs_Mouse0.86611980
162* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.86437005
163TTF2_22483619_ChIP-Seq_HELA_Human0.86309663
164PRDM14_20953172_ChIP-Seq_ESCs_Human0.85901967
165CJUN_26792858_Chip-Seq_BT549_Human0.85470945
166LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85331342
167TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85223587
168ZFX_18555785_Chip-Seq_ESCs_Mouse0.85169728
169AR_25329375_ChIP-Seq_VCAP_Human0.84921486
170TAL1_26923725_Chip-Seq_HPCs_Mouse0.84837913
171CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84785728
172TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.84733740
173CMYC_18555785_Chip-Seq_ESCs_Mouse0.84470921
174GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84390064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.88557236
2MP0005451_abnormal_body_composition5.62719832
3MP0002102_abnormal_ear_morphology5.27860955
4MP0003646_muscle_fatigue5.27709739
5MP0001986_abnormal_taste_sensitivity4.61869534
6MP0003693_abnormal_embryo_hatching3.77606806
7MP0008877_abnormal_DNA_methylation3.63261123
8MP0003787_abnormal_imprinting3.29673600
9MP0010094_abnormal_chromosome_stability2.91496978
10MP0002653_abnormal_ependyma_morphology2.81664535
11MP0005395_other_phenotype2.71778971
12MP0003699_abnormal_female_reproductive2.61467482
13MP0003123_paternal_imprinting2.57975343
14MP0003077_abnormal_cell_cycle2.57634285
15MP0001119_abnormal_female_reproductive2.56665415
16MP0005408_hypopigmentation2.55724924
17MP0003111_abnormal_nucleus_morphology2.51834896
18MP0008789_abnormal_olfactory_epithelium2.48030237
19MP0002249_abnormal_larynx_morphology2.43090136
20MP0003121_genomic_imprinting2.42791458
21MP0005423_abnormal_somatic_nervous2.37469879
22MP0004957_abnormal_blastocyst_morpholog2.33346530
23MP0002160_abnormal_reproductive_system2.29889006
24MP0006292_abnormal_olfactory_placode2.18754278
25MP0005174_abnormal_tail_pigmentation2.15026740
26MP0000579_abnormal_nail_morphology2.11097843
27MP0001929_abnormal_gametogenesis2.07005332
28MP0000653_abnormal_sex_gland2.04744347
29MP0005499_abnormal_olfactory_system1.94359763
30MP0005394_taste/olfaction_phenotype1.94359763
31MP0003937_abnormal_limbs/digits/tail_de1.90738598
32MP0002210_abnormal_sex_determination1.89295170
33MP0005551_abnormal_eye_electrophysiolog1.78047385
34MP0005410_abnormal_fertilization1.77557765
35MP0002138_abnormal_hepatobiliary_system1.75638406
36MP0000015_abnormal_ear_pigmentation1.75285047
37MP0000462_abnormal_digestive_system1.74320709
38MP0004185_abnormal_adipocyte_glucose1.66097086
39MP0005646_abnormal_pituitary_gland1.63499818
40MP0008932_abnormal_embryonic_tissue1.49027794
41MP0006035_abnormal_mitochondrial_morpho1.48358414
42MP0006036_abnormal_mitochondrial_physio1.46227287
43MP0005645_abnormal_hypothalamus_physiol1.39048796
44MP0001145_abnormal_male_reproductive1.38757857
45MP0005310_abnormal_salivary_gland1.38068564
46MP0002127_abnormal_cardiovascular_syste1.37989235
47MP0004885_abnormal_endolymph1.36933218
48MP0010368_abnormal_lymphatic_system1.36683933
49MP0002161_abnormal_fertility/fecundity1.36524144
50MP0004264_abnormal_extraembryonic_tissu1.36283956
51MP0002085_abnormal_embryonic_tissue1.35927350
52MP0003315_abnormal_perineum_morphology1.32066557
53MP0001968_abnormal_touch/_nociception1.31715111
54MP0002876_abnormal_thyroid_physiology1.31712050
55MP0001529_abnormal_vocalization1.29953270
56MP0004147_increased_porphyrin_level1.28288377
57MP0005360_urolithiasis1.27935614
58MP0000639_abnormal_adrenal_gland1.27801600
59MP0000372_irregular_coat_pigmentation1.25714979
60MP0003943_abnormal_hepatobiliary_system1.25186147
61MP0001730_embryonic_growth_arrest1.24491784
62MP0008007_abnormal_cellular_replicative1.22219093
63MP0000350_abnormal_cell_proliferation1.21054000
64MP0000566_synostosis1.20376513
65MP0002095_abnormal_skin_pigmentation1.19561768
66MP0001697_abnormal_embryo_size1.19008109
67MP0002837_dystrophic_cardiac_calcinosis1.18021678
68MP0002084_abnormal_developmental_patter1.15960140
69MP0002877_abnormal_melanocyte_morpholog1.13509941
70MP0001346_abnormal_lacrimal_gland1.11958653
71MP0004019_abnormal_vitamin_homeostasis1.10484866
72MP0003186_abnormal_redox_activity1.05743579
73MP0003136_yellow_coat_color1.04419543
74MP0003119_abnormal_digestive_system1.03322878
75MP0001915_intracranial_hemorrhage1.02670862
76MP0004215_abnormal_myocardial_fiber1.01551026
77MP0006072_abnormal_retinal_apoptosis1.01039914
78MP0002277_abnormal_respiratory_mucosa1.00378212
79MP0001905_abnormal_dopamine_level1.00062771
80MP0005380_embryogenesis_phenotype0.99268143
81MP0001672_abnormal_embryogenesis/_devel0.99268143
82MP0002735_abnormal_chemical_nociception0.98383621
83MP0005085_abnormal_gallbladder_physiolo0.96845636
84MP0000358_abnormal_cell_content/0.96357971
85MP0003755_abnormal_palate_morphology0.96151404
86MP0001851_eye_inflammation0.95095498
87MP0003879_abnormal_hair_cell0.93025808
88MP0000647_abnormal_sebaceous_gland0.91308838
89MP0010234_abnormal_vibrissa_follicle0.89702053
90MP0003656_abnormal_erythrocyte_physiolo0.88814732
91MP0009250_abnormal_appendicular_skeleto0.88809911
92MP0003195_calcinosis0.88370990
93MP0005257_abnormal_intraocular_pressure0.87943563
94MP0004510_myositis0.86045326
95MP0004145_abnormal_muscle_electrophysio0.85762524
96MP0009333_abnormal_splenocyte_physiolog0.83518142
97MP0005187_abnormal_penis_morphology0.83222307
98MP0004270_analgesia0.81311459
99MP0003698_abnormal_male_reproductive0.81238480
100MP0005075_abnormal_melanosome_morpholog0.80751174
101MP0005253_abnormal_eye_physiology0.80340838
102MP0002139_abnormal_hepatobiliary_system0.79386460
103MP0002019_abnormal_tumor_incidence0.78867220
104MP0008872_abnormal_physiological_respon0.78425990
105MP0002736_abnormal_nociception_after0.78001235
106MP0001849_ear_inflammation0.77739921
107MP0001764_abnormal_homeostasis0.77592332
108MP0003936_abnormal_reproductive_system0.76919502
109MP0010386_abnormal_urinary_bladder0.75767952
110MP0002751_abnormal_autonomic_nervous0.75503945
111MP0000678_abnormal_parathyroid_gland0.75488180
112MP0003567_abnormal_fetal_cardiomyocyte0.75112726
113MP0001502_abnormal_circadian_rhythm0.74760374
114MP0008995_early_reproductive_senescence0.74331593
115MP0001324_abnormal_eye_pigmentation0.73515930
116MP0002234_abnormal_pharynx_morphology0.72666668
117MP0008058_abnormal_DNA_repair0.72589718
118MP0001963_abnormal_hearing_physiology0.70889202
119MP0003786_premature_aging0.70219498
120MP0000049_abnormal_middle_ear0.70150836
121MP0002116_abnormal_craniofacial_bone0.69863644
122MP0003183_abnormal_peptide_metabolism0.69458682
123MP0004142_abnormal_muscle_tone0.69115830
124MP0003984_embryonic_growth_retardation0.68202063
125MP0002177_abnormal_outer_ear0.68079572
126MP0002938_white_spotting0.67188733
127MP0002254_reproductive_system_inflammat0.65454838
128MP0000383_abnormal_hair_follicle0.65066326
129MP0000432_abnormal_head_morphology0.64808254
130MP0003950_abnormal_plasma_membrane0.63921800
131MP0002638_abnormal_pupillary_reflex0.63880594
132MP0008057_abnormal_DNA_replication0.63864691
133MP0002088_abnormal_embryonic_growth/wei0.63235669
134MP0003329_amyloid_beta_deposits0.63145173
135MP0005647_abnormal_sex_gland0.60956975
136MP0005621_abnormal_cell_physiology0.60780877
137MP0009697_abnormal_copulation0.60748041
138MP0000613_abnormal_salivary_gland0.60658476
139MP0003861_abnormal_nervous_system0.60509078
140MP0010030_abnormal_orbit_morphology0.59866926
141MP0000490_abnormal_crypts_of0.59492722
142MP0002086_abnormal_extraembryonic_tissu0.59059786
143MP0000631_abnormal_neuroendocrine_gland0.58516630
144MP0001919_abnormal_reproductive_system0.58169621
145MP0003453_abnormal_keratinocyte_physiol0.57816184
146MP0003935_abnormal_craniofacial_develop0.57536773
147MP0009384_cardiac_valve_regurgitation0.56646746
148MP0002282_abnormal_trachea_morphology0.55734373
149MP0002109_abnormal_limb_morphology0.55565997
150MP0000569_abnormal_digit_pigmentation0.55185769
151MP0002080_prenatal_lethality0.54147178
152MP0002168_other_aberrant_phenotype0.53864728
153MP0000427_abnormal_hair_cycle0.53853532
154MP0002233_abnormal_nose_morphology0.52942563
155MP0010307_abnormal_tumor_latency0.52446055
156MP0002932_abnormal_joint_morphology0.52188333
157MP0002163_abnormal_gland_morphology0.51972161
158MP0005389_reproductive_system_phenotype0.49949898
159MP0003890_abnormal_embryonic-extraembry0.49948458
160MP0005248_abnormal_Harderian_gland0.45952012

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.94268963
2Papillary thyroid carcinoma (HP:0002895)5.81401193
3Shawl scrotum (HP:0000049)4.74571403
4Chromsome breakage (HP:0040012)4.70733183
5Flat capital femoral epiphysis (HP:0003370)4.60678946
6Facial hemangioma (HP:0000329)4.59356200
7Cortical dysplasia (HP:0002539)4.55623578
8Adrenal hypoplasia (HP:0000835)4.39125728
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.20260487
10Abnormality of the labia minora (HP:0012880)4.08019256
11Patellar aplasia (HP:0006443)4.06386825
12Birth length less than 3rd percentile (HP:0003561)4.02986099
13Breast hypoplasia (HP:0003187)3.83634823
14Aplasia/Hypoplasia of the patella (HP:0006498)3.75079198
15Abnormality of the fingertips (HP:0001211)3.63243350
16Acute myeloid leukemia (HP:0004808)3.60138009
17Short tibia (HP:0005736)3.55087619
18Secondary amenorrhea (HP:0000869)3.46796926
19Capillary hemangiomas (HP:0005306)3.45936093
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.45087397
21Lip pit (HP:0100267)3.38294804
22Aplasia/Hypoplasia of the tibia (HP:0005772)3.37717898
23Premature ovarian failure (HP:0008209)3.28302417
24Insulin-resistant diabetes mellitus (HP:0000831)3.23923363
25Arterial tortuosity (HP:0005116)3.12159976
26Pancreatic cysts (HP:0001737)3.10065867
27Thyroid carcinoma (HP:0002890)3.06783983
28Pulmonary fibrosis (HP:0002206)3.05142274
29Breast aplasia (HP:0100783)3.00264414
30Aplasia/Hypoplasia of the breasts (HP:0010311)2.99334522
31Microvesicular hepatic steatosis (HP:0001414)2.99163583
32Abnormality of lateral ventricle (HP:0030047)2.98883023
33Abnormality of chromosome segregation (HP:0002916)2.97573977
34Hypergonadotropic hypogonadism (HP:0000815)2.91485670
35Congenital stationary night blindness (HP:0007642)2.91174717
36Abdominal situs inversus (HP:0003363)2.90068350
37Abnormality of abdominal situs (HP:0011620)2.90068350
38Oligodactyly (hands) (HP:0001180)2.87653791
39Sandal gap (HP:0001852)2.84096500
403-Methylglutaconic aciduria (HP:0003535)2.80630182
41Median cleft lip (HP:0000161)2.78111198
42Infertility (HP:0000789)2.77721232
43Spondylolisthesis (HP:0003302)2.76359109
44Abnormality of chromosome stability (HP:0003220)2.68809259
45Vascular tortuosity (HP:0004948)2.67622692
46Sparse lateral eyebrow (HP:0005338)2.64961586
47Hyperglycemia (HP:0003074)2.60488185
48Oligodactyly (HP:0012165)2.60033624
49Chronic bronchitis (HP:0004469)2.56229148
50Hypomagnesemia (HP:0002917)2.55618673
51Aplasia/hypoplasia of the uterus (HP:0008684)2.55314578
52Severe visual impairment (HP:0001141)2.51031004
53Primary amenorrhea (HP:0000786)2.50500341
54Abnormality of the fovea (HP:0000493)2.49647462
55Midline defect of the nose (HP:0004122)2.49045049
56Progressive inability to walk (HP:0002505)2.47658404
57Azoospermia (HP:0000027)2.45933440
58Abnormal drinking behavior (HP:0030082)2.45669280
59Polydipsia (HP:0001959)2.45669280
60Supernumerary spleens (HP:0009799)2.45626960
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.43257528
62Prostate neoplasm (HP:0100787)2.41652615
63Abnormality of the epiphysis of the femoral head (HP:0010574)2.40488668
64Overlapping toe (HP:0001845)2.38933978
65Osteomalacia (HP:0002749)2.33276927
66Abnormality of the preputium (HP:0100587)2.32722730
67Abnormal biliary tract physiology (HP:0012439)2.29124732
68Bile duct proliferation (HP:0001408)2.29124732
69Abnormality of the phalanges of the hallux (HP:0010057)2.28920929
70Cystic hygroma (HP:0000476)2.28240791
71Ectopic kidney (HP:0000086)2.22473969
72Abnormality of magnesium homeostasis (HP:0004921)2.21054303
73Horseshoe kidney (HP:0000085)2.20488696
74Abnormality of the femoral head (HP:0003368)2.19855029
75Anterior segment dysgenesis (HP:0007700)2.18845975
76Abnormality of the renal cortex (HP:0011035)2.18654135
77Hypoplasia of the fovea (HP:0007750)2.18188806
78Aplasia/Hypoplasia of the fovea (HP:0008060)2.18188806
79Aplasia/Hypoplasia of the tongue (HP:0010295)2.17274724
80Meckel diverticulum (HP:0002245)2.17217628
81Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.16920383
82Abnormality of femoral epiphyses (HP:0006499)2.16920383
83Abnormality of the renal collecting system (HP:0004742)2.15477998
84Wrist flexion contracture (HP:0001239)2.13391716
85Abnormality of the proximal phalanges of the hand (HP:0009834)2.10392548
86Camptodactyly of toe (HP:0001836)2.10354631
87Double outlet right ventricle (HP:0001719)2.07799923
88Congenital malformation of the right heart (HP:0011723)2.07799923
89Testicular atrophy (HP:0000029)2.06781931
90Tubular atrophy (HP:0000092)2.06723654
91Hypoplastic iliac wings (HP:0002866)2.06457084
92Malnutrition (HP:0004395)2.05940456
93Hypoplasia of the uterus (HP:0000013)2.05757776
94Absent radius (HP:0003974)2.05086494
95Methylmalonic aciduria (HP:0012120)2.04947304
96Medial flaring of the eyebrow (HP:0010747)2.04891323
97Attenuation of retinal blood vessels (HP:0007843)2.02945047
98Dynein arm defect of respiratory motile cilia (HP:0012255)2.01915465
99Absent/shortened dynein arms (HP:0200106)2.01915465
100Abnormality of small intestinal villus morphology (HP:0011472)2.01587442
101Villous atrophy (HP:0011473)2.01587442
102Tubulointerstitial nephritis (HP:0001970)2.01357560
103Pendular nystagmus (HP:0012043)2.00808720
104Type II lissencephaly (HP:0007260)2.00358688
105Nonprogressive disorder (HP:0003680)2.00100848
106Abnormality of the ileum (HP:0001549)1.99616044
107Abnormality of the pons (HP:0007361)1.98291511
108Rib fusion (HP:0000902)1.98269410
109Sloping forehead (HP:0000340)1.97996005
110True hermaphroditism (HP:0010459)1.97967787
111Hypophosphatemic rickets (HP:0004912)1.97867684
112Thyroid-stimulating hormone excess (HP:0002925)1.97509674
113Abnormal spermatogenesis (HP:0008669)1.97439653
114Abnormal pancreas size (HP:0012094)1.97011742
115Aplasia involving forearm bones (HP:0009822)1.96521145
116Absent forearm bone (HP:0003953)1.96521145
117Clubbing of toes (HP:0100760)1.96039980
118Abnormal rod and cone electroretinograms (HP:0008323)1.94641425
119Abnormality of macular pigmentation (HP:0008002)1.94566200
120Pancreatic fibrosis (HP:0100732)1.93896677
121Glycosuria (HP:0003076)1.93009355
122Abnormality of urine glucose concentration (HP:0011016)1.93009355
123Absent septum pellucidum (HP:0001331)1.92862883
124Carpal bone hypoplasia (HP:0001498)1.92471279
125Gaze-evoked nystagmus (HP:0000640)1.92268151
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91929759
127Increased serum lactate (HP:0002151)1.91439797
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91316221
129Abnormality of alanine metabolism (HP:0010916)1.91316221
130Hyperalaninemia (HP:0003348)1.91316221
131Duplicated collecting system (HP:0000081)1.90084565
132Polyuria (HP:0000103)1.90039720
133Sensory axonal neuropathy (HP:0003390)1.89707751
134Aplasia/Hypoplasia of the macula (HP:0008059)1.89698474
135Myelodysplasia (HP:0002863)1.87414805
136Small intestinal stenosis (HP:0012848)1.86041244
137Duodenal stenosis (HP:0100867)1.86041244
138Type 2 muscle fiber atrophy (HP:0003554)1.85986091
139Fibular aplasia (HP:0002990)1.85444075
140Aplasia/Hypoplasia involving the musculature (HP:0001460)1.84859099
141Absent thumb (HP:0009777)1.84761734
142Methylmalonic acidemia (HP:0002912)1.84146010
143Short thumb (HP:0009778)1.83990499
144Chronic hepatic failure (HP:0100626)1.83636169
145Impulsivity (HP:0100710)1.83615150
146Hypokinesia (HP:0002375)1.83271112
147Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82464689
148Microglossia (HP:0000171)1.82169107
149Nephronophthisis (HP:0000090)1.81756107
150Abnormality of the intervertebral disk (HP:0005108)1.81314540
151Abnormality of the renal medulla (HP:0100957)1.80851194
152Abnormality of the septum pellucidum (HP:0007375)1.80809214
153Cleft eyelid (HP:0000625)1.80725919
154Amelogenesis imperfecta (HP:0000705)1.80178020
155Fetal akinesia sequence (HP:0001989)1.79905646
156Muscle fiber atrophy (HP:0100295)1.79129613
157Neoplasm of the oral cavity (HP:0100649)1.78749134
158Increased CSF lactate (HP:0002490)1.77530881
159Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76933866
160Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75900155
161Aplasia/Hypoplasia of the sternum (HP:0006714)1.74412058
162Retrobulbar optic neuritis (HP:0100654)1.73537146
163Optic neuritis (HP:0100653)1.73537146
164Arachnodactyly (HP:0001166)1.71604022
165Cafe-au-lait spot (HP:0000957)1.71517830
166Tetany (HP:0001281)1.71133507
167Molar tooth sign on MRI (HP:0002419)1.70806072
168Abnormality of midbrain morphology (HP:0002418)1.70806072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.91900333
2MAP3K63.83282008
3MUSK3.78482033
4EEF2K3.66414978
5ERBB43.63170702
6LATS23.60610817
7KSR23.54329056
8PLK43.46825122
9TAOK33.26757149
10BRAF3.21630032
11MAP3K92.91490023
12TAOK12.81050176
13TTK2.77850691
14SRPK12.73430520
15STK38L2.66661819
16TRIM282.58273650
17RAF12.49184744
18MST42.47354510
19MAP3K132.43998739
20ADRBK22.38977550
21MAPKAPK32.38136567
22CDC72.20812627
23ZAK2.20449882
24FRK2.17889455
25PBK2.15999027
26ARAF2.10312030
27MAP4K21.98918323
28CDK81.80940728
29MOS1.76884559
30EIF2AK31.72518232
31STK31.66329150
32KSR11.65426066
33PAK61.65149221
34GRK11.64800434
35LIMK11.64225364
36STK161.63233345
37NEK61.61153540
38CHEK21.57323996
39NEK21.54781636
40MELK1.50738436
41WNK31.43680588
42STK391.42032666
43PRKD31.42008314
44MAPKAPK51.39820119
45PDK21.36860326
46OXSR11.30929449
47PRKCI1.30683474
48CDK91.29999698
49MAPK131.29617166
50NTRK31.27445206
51CDK191.24499276
52PHKG21.20446678
53PHKG11.20446678
54MAP3K41.14497922
55BRSK21.13196013
56TGFBR11.12048535
57WNK41.10505988
58DMPK1.05311215
59STK101.04843438
60TLK11.04540154
61PLK11.03205889
62PRKD21.01710053
63TRPM70.97111470
64PRKCE0.90907432
65INSRR0.88194586
66TESK20.88057032
67RPS6KB20.86281394
68MARK20.85696906
69PRKAA20.84071980
70MAP3K80.82512143
71PKN10.81054736
72TYRO30.80443294
73DYRK20.80270027
74STK380.79911283
75MAP2K70.78541373
76VRK20.77844824
77CDK120.74518128
78PIM10.74281886
79TNIK0.74256576
80TIE10.72386310
81ABL20.70838924
82NME10.68584814
83ACVR1B0.67532740
84NTRK20.66886324
85AURKB0.66625445
86BMPR20.65018919
87PRKAA10.63434176
88NUAK10.62252319
89RET0.61931123
90MAP2K40.61302867
91MKNK20.58386056
92STK240.53717866
93PRKCG0.52968335
94AURKA0.52140116
95CHEK10.51393217
96CLK10.50835474
97MAPK110.50518152
98PNCK0.50431542
99CSNK2A10.50067167
100MAP3K50.49357842
101DYRK30.48181041
102CSNK1A10.46831551
103CSNK1G10.46389672
104PLK30.46129405
105MET0.45430681
106CDK30.44967821
107PRKG10.43957226
108ATM0.43280565
109NEK90.39960795
110ADRBK10.38321218
111CSNK2A20.36910989
112BMX0.36910285
113MAP2K60.36622002
114SGK20.36458365
115BUB10.36237338
116MARK30.36051539
117TXK0.36005816
118CSNK1G20.35781418
119NLK0.34863263
120CDK70.34556593
121MAP3K10.34178351
122EIF2AK20.33737018
123LMTK20.33090652
124PIK3CA0.32702514
125WEE10.31898723
126EPHA30.28992844
127BRSK10.28456869
128ABL10.27052957
129CDK10.26971271
130CAMK2A0.26065937
131MAP2K10.25662203
132CDK20.25164608
133PINK10.24867735
134BMPR1B0.24821094
135CSNK1G30.23299083
136RPS6KA40.22621923
137CDK40.22190038
138VRK10.21450104
139JAK30.21216090
140FGR0.20510839
141MAPK100.20469238
142SGK4940.19924641
143SGK2230.19924641
144PAK30.15960722
145JAK20.15032278
146PAK10.14308160
147CSNK1D0.13586452
148AKT10.12375741
149MAPK140.12274829
150GSK3B0.11984456
151PLK20.11803538
152CSNK1E0.11194206
153EPHA40.10499814
154ATR0.10265006

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.14285963
2Ovarian steroidogenesis_Homo sapiens_hsa049133.77406433
3RNA degradation_Homo sapiens_hsa030183.69616933
4Basal transcription factors_Homo sapiens_hsa030223.35292034
5Vitamin B6 metabolism_Homo sapiens_hsa007503.01590016
6Regulation of autophagy_Homo sapiens_hsa041402.94108163
7Circadian rhythm_Homo sapiens_hsa047102.86369940
8Pancreatic cancer_Homo sapiens_hsa052122.57101292
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.47616642
10Linoleic acid metabolism_Homo sapiens_hsa005912.42284526
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.31815607
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.27149305
13Ether lipid metabolism_Homo sapiens_hsa005652.20703299
14Homologous recombination_Homo sapiens_hsa034402.09320282
15Oocyte meiosis_Homo sapiens_hsa041142.09003777
16TGF-beta signaling pathway_Homo sapiens_hsa043502.01017900
17p53 signaling pathway_Homo sapiens_hsa041152.00330147
18Dorso-ventral axis formation_Homo sapiens_hsa043201.90489438
19Phototransduction_Homo sapiens_hsa047441.89037648
20Fanconi anemia pathway_Homo sapiens_hsa034601.88006214
21GnRH signaling pathway_Homo sapiens_hsa049121.78499804
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73844171
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70178420
24Prolactin signaling pathway_Homo sapiens_hsa049171.63837053
25Colorectal cancer_Homo sapiens_hsa052101.62851771
26Caffeine metabolism_Homo sapiens_hsa002321.62478745
27Protein export_Homo sapiens_hsa030601.62369495
28Ribosome_Homo sapiens_hsa030101.60654536
29Choline metabolism in cancer_Homo sapiens_hsa052311.59230884
30RNA transport_Homo sapiens_hsa030131.55787316
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53071089
32Oxidative phosphorylation_Homo sapiens_hsa001901.44427412
33Proteasome_Homo sapiens_hsa030501.43728946
34Non-homologous end-joining_Homo sapiens_hsa034501.43220629
35MicroRNAs in cancer_Homo sapiens_hsa052061.42103498
36Renal cell carcinoma_Homo sapiens_hsa052111.34870586
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.33452819
38VEGF signaling pathway_Homo sapiens_hsa043701.31975496
39Base excision repair_Homo sapiens_hsa034101.30590192
40Selenocompound metabolism_Homo sapiens_hsa004501.30321399
41Parkinsons disease_Homo sapiens_hsa050121.22509887
42Collecting duct acid secretion_Homo sapiens_hsa049661.19923343
43Huntingtons disease_Homo sapiens_hsa050161.18358634
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18342887
45RNA polymerase_Homo sapiens_hsa030201.17119753
46Spliceosome_Homo sapiens_hsa030401.16826791
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14942309
48Olfactory transduction_Homo sapiens_hsa047401.14675633
49Endometrial cancer_Homo sapiens_hsa052131.10935372
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10648551
51Steroid biosynthesis_Homo sapiens_hsa001001.09443913
52Nitrogen metabolism_Homo sapiens_hsa009101.02560968
53Adherens junction_Homo sapiens_hsa045201.01647249
54Long-term depression_Homo sapiens_hsa047301.00169366
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.98230666
56Hippo signaling pathway_Homo sapiens_hsa043900.97933645
57FoxO signaling pathway_Homo sapiens_hsa040680.97696094
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97678706
59Taste transduction_Homo sapiens_hsa047420.97333761
60Nicotine addiction_Homo sapiens_hsa050330.96661473
61Mismatch repair_Homo sapiens_hsa034300.95277606
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.94268947
63Non-small cell lung cancer_Homo sapiens_hsa052230.93900788
64Thyroid cancer_Homo sapiens_hsa052160.92304554
65mTOR signaling pathway_Homo sapiens_hsa041500.91274916
66Nucleotide excision repair_Homo sapiens_hsa034200.91184503
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90670889
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88821993
69Fatty acid elongation_Homo sapiens_hsa000620.86593166
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86432573
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85678846
72Ras signaling pathway_Homo sapiens_hsa040140.85616083
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.85510241
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83741806
75Chronic myeloid leukemia_Homo sapiens_hsa052200.82854086
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82386072
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82141583
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80764728
79Small cell lung cancer_Homo sapiens_hsa052220.79678547
80DNA replication_Homo sapiens_hsa030300.79139563
81Bladder cancer_Homo sapiens_hsa052190.75584314
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74655863
83mRNA surveillance pathway_Homo sapiens_hsa030150.73583076
84Notch signaling pathway_Homo sapiens_hsa043300.72225125
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72060090
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.71611633
87Propanoate metabolism_Homo sapiens_hsa006400.71290551
88Hepatitis B_Homo sapiens_hsa051610.70716502
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65953904
90ErbB signaling pathway_Homo sapiens_hsa040120.64085038
91Estrogen signaling pathway_Homo sapiens_hsa049150.63663309
92Prostate cancer_Homo sapiens_hsa052150.63330364
93One carbon pool by folate_Homo sapiens_hsa006700.61121651
94Inositol phosphate metabolism_Homo sapiens_hsa005620.60768713
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58714686
96Metabolic pathways_Homo sapiens_hsa011000.57509228
97Glioma_Homo sapiens_hsa052140.57466013
98Lysine degradation_Homo sapiens_hsa003100.55226402
99ABC transporters_Homo sapiens_hsa020100.52857965
100Arachidonic acid metabolism_Homo sapiens_hsa005900.52266601
101Synaptic vesicle cycle_Homo sapiens_hsa047210.51582333
102Serotonergic synapse_Homo sapiens_hsa047260.50916715
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50280017
104Cardiac muscle contraction_Homo sapiens_hsa042600.49510376
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49224704
106HTLV-I infection_Homo sapiens_hsa051660.48386812
107Insulin secretion_Homo sapiens_hsa049110.47577180
108MAPK signaling pathway_Homo sapiens_hsa040100.47314013
109Sulfur metabolism_Homo sapiens_hsa009200.47208559
110Melanoma_Homo sapiens_hsa052180.47163904
111Other glycan degradation_Homo sapiens_hsa005110.46424886
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.45863647
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45072518
114Herpes simplex infection_Homo sapiens_hsa051680.44600618
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42719606
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.42602357
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.42155119
118cAMP signaling pathway_Homo sapiens_hsa040240.40926316
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40919047
120Glutamatergic synapse_Homo sapiens_hsa047240.39617361
121Purine metabolism_Homo sapiens_hsa002300.39326325
122Peroxisome_Homo sapiens_hsa041460.38638048
123Glutathione metabolism_Homo sapiens_hsa004800.37071575
124Vitamin digestion and absorption_Homo sapiens_hsa049770.36784177
125Wnt signaling pathway_Homo sapiens_hsa043100.36658013
126TNF signaling pathway_Homo sapiens_hsa046680.36155044
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.35899823
128Alzheimers disease_Homo sapiens_hsa050100.34586680
129Mineral absorption_Homo sapiens_hsa049780.33675454
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33450959
131Pathways in cancer_Homo sapiens_hsa052000.33116527
132Pyrimidine metabolism_Homo sapiens_hsa002400.31646856
133Butanoate metabolism_Homo sapiens_hsa006500.31645714
134Retinol metabolism_Homo sapiens_hsa008300.30791374
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30575000
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30287807
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.29507941
138Oxytocin signaling pathway_Homo sapiens_hsa049210.28867869
139Fat digestion and absorption_Homo sapiens_hsa049750.28778848
140Sulfur relay system_Homo sapiens_hsa041220.28557520
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28544284
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27217645
143Chemical carcinogenesis_Homo sapiens_hsa052040.26628530
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25803969
145Shigellosis_Homo sapiens_hsa051310.25238776
146Morphine addiction_Homo sapiens_hsa050320.25220080
147AMPK signaling pathway_Homo sapiens_hsa041520.24191561
148Arginine and proline metabolism_Homo sapiens_hsa003300.21757126
149Sphingolipid metabolism_Homo sapiens_hsa006000.21614123
150Hedgehog signaling pathway_Homo sapiens_hsa043400.21587914
151Platelet activation_Homo sapiens_hsa046110.20725205
152Tryptophan metabolism_Homo sapiens_hsa003800.20614465
153RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20388760
154Calcium signaling pathway_Homo sapiens_hsa040200.19921767
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19555691
156Rap1 signaling pathway_Homo sapiens_hsa040150.19359100
157Viral carcinogenesis_Homo sapiens_hsa052030.18970291
158Arginine biosynthesis_Homo sapiens_hsa002200.18443690
159Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16551067
160Epstein-Barr virus infection_Homo sapiens_hsa051690.15378947
161Folate biosynthesis_Homo sapiens_hsa007900.15069267
162Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.13999669

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »