ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to cilium (GO:0061512)	4.91277680
2	regulation of transmission of nerve impulse (GO:0051969)	4.40760979
3	DNA deamination (GO:0045006)	4.31252056
4	respiratory chain complex IV assembly (GO:0008535)	4.11030902
5	cytochrome complex assembly (GO:0017004)	4.00691964
6	inositol phosphate catabolic process (GO:0071545)	3.76467832
7	L-fucose catabolic process (GO:0042355)	3.72757313
8	fucose catabolic process (GO:0019317)	3.72757313
9	L-fucose metabolic process (GO:0042354)	3.72757313
10	detection of light stimulus involved in sensory perception (GO:0050962)	3.66920395
11	detection of light stimulus involved in visual perception (GO:0050908)	3.66920395
12	regulation of mitochondrial translation (GO:0070129)	3.59990557
13	terpenoid biosynthetic process (GO:0016114)	3.56172390
14	inositol phosphate dephosphorylation (GO:0046855)	3.50742900
15	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.50742900
16	protein complex biogenesis (GO:0070271)	3.49807200
17	organelle disassembly (GO:1903008)	3.49053400
18	ribonucleoprotein complex disassembly (GO:0032988)	3.48299839
19	water-soluble vitamin biosynthetic process (GO:0042364)	3.46953667
20	regulation of cilium movement (GO:0003352)	3.46344930
21	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.45974553
22	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.43336146
23	glycerophospholipid catabolic process (GO:0046475)	3.42087034
24	behavioral response to nicotine (GO:0035095)	3.39069770
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.38621202
26	diterpenoid biosynthetic process (GO:0016102)	3.34258023
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.33779945
28	preassembly of GPI anchor in ER membrane (GO:0016254)	3.31433269
29	negative regulation of neurological system process (GO:0031645)	3.28664561
30	dentate gyrus development (GO:0021542)	3.26735051
31	mannosylation (GO:0097502)	3.26652161
32	protein-cofactor linkage (GO:0018065)	3.26642462
33	protein prenylation (GO:0018342)	3.21036023
34	prenylation (GO:0097354)	3.21036023
35	GPI anchor biosynthetic process (GO:0006506)	3.16150590
36	branched-chain amino acid catabolic process (GO:0009083)	3.15408934
37	rhodopsin mediated signaling pathway (GO:0016056)	3.14992390
38	piRNA metabolic process (GO:0034587)	3.14659179
39	valine metabolic process (GO:0006573)	3.10737599
40	electron transport chain (GO:0022900)	3.04426925
41	polyol catabolic process (GO:0046174)	3.03719201
42	respiratory electron transport chain (GO:0022904)	3.01193322
43	rRNA modification (GO:0000154)	2.99832800
44	protein neddylation (GO:0045116)	2.99320789
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.98176044
46	NADH dehydrogenase complex assembly (GO:0010257)	2.98176044
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.98176044
48	GPI anchor metabolic process (GO:0006505)	2.96873482
49	platelet dense granule organization (GO:0060155)	2.96192477
50	amino acid salvage (GO:0043102)	2.95294837
51	L-methionine salvage (GO:0071267)	2.95294837
52	L-methionine biosynthetic process (GO:0071265)	2.95294837
53	metallo-sulfur cluster assembly (GO:0031163)	2.93432771
54	iron-sulfur cluster assembly (GO:0016226)	2.93432771
55	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.89538916
56	base-excision repair, AP site formation (GO:0006285)	2.88628877
57	negative regulation of appetite (GO:0032099)	2.88626270
58	negative regulation of response to food (GO:0032096)	2.88626270
59	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.87362169
60	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.86638994
61	rRNA methylation (GO:0031167)	2.86526306
62	receptor guanylyl cyclase signaling pathway (GO:0007168)	2.86413400
63	regulation of microtubule-based movement (GO:0060632)	2.85817875
64	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.83115320
65	C-terminal protein lipidation (GO:0006501)	2.82108467
66	anterograde synaptic vesicle transport (GO:0048490)	2.81529348
67	isoprenoid biosynthetic process (GO:0008299)	2.80478890
68	ATP synthesis coupled proton transport (GO:0015986)	2.77600019
69	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.77600019
70	protein polyglutamylation (GO:0018095)	2.75266472
71	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.74879775
72	auditory receptor cell stereocilium organization (GO:0060088)	2.69869123
73	maturation of 5.8S rRNA (GO:0000460)	2.66543524
74	GTP biosynthetic process (GO:0006183)	2.62915231
75	intraciliary transport (GO:0042073)	2.59866434
76	righting reflex (GO:0060013)	2.59594230
77	regulation of hexokinase activity (GO:1903299)	2.58908187
78	regulation of glucokinase activity (GO:0033131)	2.58908187
79	protein localization to Golgi apparatus (GO:0034067)	2.55912205
80	branched-chain amino acid metabolic process (GO:0009081)	2.55461092
81	regulation of acrosome reaction (GO:0060046)	2.54565743
82	C-terminal protein amino acid modification (GO:0018410)	2.51023888
83	cAMP catabolic process (GO:0006198)	2.49746920
84	reflex (GO:0060004)	2.49160111
85	adenosine metabolic process (GO:0046085)	2.48996828
86	pyrimidine nucleotide catabolic process (GO:0006244)	2.48649448
87	L-ascorbic acid metabolic process (GO:0019852)	2.48324382
88	DNA demethylation (GO:0080111)	2.46878331
89	kynurenine metabolic process (GO:0070189)	2.44018906
90	endocrine pancreas development (GO:0031018)	2.43777596
91	regulation of meiosis I (GO:0060631)	2.43755739
92	proteasome assembly (GO:0043248)	2.42230225
93	positive regulation of mRNA 3-end processing (GO:0031442)	2.42198671
94	tachykinin receptor signaling pathway (GO:0007217)	2.42132581
95	glycolipid biosynthetic process (GO:0009247)	2.40424452
96	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.39890111
97	negative regulation of telomere maintenance (GO:0032205)	2.38809112
98	embryonic viscerocranium morphogenesis (GO:0048703)	2.37124662
99	magnesium ion transport (GO:0015693)	2.35728015
100	negative regulation of membrane potential (GO:0045837)	2.35100859

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.42858115
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.30797966
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.27833685
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.07165808
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.02523766
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.01854264
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.91739425
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.83288893
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.69533285
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.48798473
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.47790668
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.40990560
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.39322989
14	EWS_26573619_Chip-Seq_HEK293_Human	2.33325091
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.18065567
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.05869979
17	FUS_26573619_Chip-Seq_HEK293_Human	2.02450876
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.97567061
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.91978741
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.90265226
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.88171285
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.83662340
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.80941435
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80939140
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.75328976
26	P300_19829295_ChIP-Seq_ESCs_Human	1.74580132
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.71891714
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.71531257
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71337941
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.68727100
31	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68341962
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.67949633
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.61849551
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.60176542
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57228660
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.56372692
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.49001776
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47949946
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.47235253
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.45283896
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.43118088
42	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41009753
43	HTT_18923047_ChIP-ChIP_STHdh_Human	1.39673140
44	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.37962670
45	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.34197468
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33481615
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33481615
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32626702
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.32465969
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31037607
51	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.31024744
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30840430
53	TAF15_26573619_Chip-Seq_HEK293_Human	1.30549704
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29076766
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28707019
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28707019
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26124141
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25250458
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24808892
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22816269
61	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.18432293
62	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.17741283
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17415603
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16464936
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16176865
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.16176865
67	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.13821244
68	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.13472552
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13002826
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.12737772
71	AR_20517297_ChIP-Seq_VCAP_Human	1.12017990
72	BCAT_22108803_ChIP-Seq_LS180_Human	1.11744334
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11128876
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08865252
75	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.08339042
76	TCF4_23295773_ChIP-Seq_U87_Human	1.07593053
77	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.04504630
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.04250607
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03576039
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03424196
81	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02878607
82	NCOR_22424771_ChIP-Seq_293T_Human	1.02264912
83	AR_25329375_ChIP-Seq_VCAP_Human	1.01944343
84	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99668583
85	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99089182
86	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98674316
87	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.97891081
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97583639
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97300650
90	STAT3_23295773_ChIP-Seq_U87_Human	0.97041477
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96988281
92	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.96757375
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96651503
94	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.96486656
95	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96228788
96	DCP1A_22483619_ChIP-Seq_HELA_Human	0.96150000
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.95443439
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93343365
99	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93070024
100	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92220409

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	5.87678116
2	MP0002837_dystrophic_cardiac_calcinosis	3.40232132
3	MP0005379_endocrine/exocrine_gland_phen	3.06961531
4	MP0002138_abnormal_hepatobiliary_system	3.05020439
5	MP0003195_calcinosis	3.00286486
6	MP0008877_abnormal_DNA_methylation	2.90457001
7	MP0005551_abnormal_eye_electrophysiolog	2.41499440
8	MP0003011_delayed_dark_adaptation	2.32582945
9	MP0008058_abnormal_DNA_repair	2.26613871
10	MP0002163_abnormal_gland_morphology	2.22578086
11	MP0005645_abnormal_hypothalamus_physiol	2.15566731
12	MP0010386_abnormal_urinary_bladder	2.11777678
13	MP0006276_abnormal_autonomic_nervous	2.07417806
14	MP0002234_abnormal_pharynx_morphology	2.06551854
15	MP0005084_abnormal_gallbladder_morpholo	2.04088682
16	MP0009046_muscle_twitch	1.91648561
17	MP0005253_abnormal_eye_physiology	1.85459023
18	MP0002928_abnormal_bile_duct	1.84778840
19	MP0001968_abnormal_touch/_nociception	1.81513251
20	MP0001984_abnormal_olfaction	1.77420753
21	MP0003122_maternal_imprinting	1.75969218
22	MP0002139_abnormal_hepatobiliary_system	1.75153622
23	MP0004043_abnormal_pH_regulation	1.73035674
24	MP0009697_abnormal_copulation	1.72344949
25	MP0010094_abnormal_chromosome_stability	1.70671313
26	MP0003283_abnormal_digestive_organ	1.68254954
27	MP0008875_abnormal_xenobiotic_pharmacok	1.63694778
28	MP0000372_irregular_coat_pigmentation	1.63059402
29	MP0004147_increased_porphyrin_level	1.56892830
30	MP0001905_abnormal_dopamine_level	1.51562296
31	MP0002876_abnormal_thyroid_physiology	1.48799474
32	MP0002638_abnormal_pupillary_reflex	1.45164238
33	MP0006072_abnormal_retinal_apoptosis	1.41697529
34	MP0004142_abnormal_muscle_tone	1.39811538
35	MP0002693_abnormal_pancreas_physiology	1.39412021
36	MP0001529_abnormal_vocalization	1.33860665
37	MP0003718_maternal_effect	1.33411465
38	MP0003786_premature_aging	1.32472701
39	MP0008995_early_reproductive_senescence	1.31410573
40	MP0005220_abnormal_exocrine_pancreas	1.30446961
41	MP0003252_abnormal_bile_duct	1.28057041
42	MP0005075_abnormal_melanosome_morpholog	1.27244214
43	MP0002736_abnormal_nociception_after	1.25720494
44	MP0008872_abnormal_physiological_respon	1.24995063
45	MP0000013_abnormal_adipose_tissue	1.23732258
46	MP0002653_abnormal_ependyma_morphology	1.21886691
47	MP0003943_abnormal_hepatobiliary_system	1.18804676
48	MP0001764_abnormal_homeostasis	1.16845488
49	MP0001486_abnormal_startle_reflex	1.16436638
50	MP0002733_abnormal_thermal_nociception	1.14006347
51	MP0006036_abnormal_mitochondrial_physio	1.12834582
52	MP0003121_genomic_imprinting	1.12341859
53	MP0002909_abnormal_adrenal_gland	1.12138631
54	MP0005332_abnormal_amino_acid	1.11696042
55	MP0004133_heterotaxia	1.10904404
56	MP0003787_abnormal_imprinting	1.09555656
57	MP0002272_abnormal_nervous_system	1.08053980
58	MP0005410_abnormal_fertilization	1.06899437
59	MP0002572_abnormal_emotion/affect_behav	1.05054170
60	MP0000427_abnormal_hair_cycle	1.03507393
61	MP0001944_abnormal_pancreas_morphology	1.03449109
62	MP0004215_abnormal_myocardial_fiber	1.03225593
63	MP0000230_abnormal_systemic_arterial	1.02010264
64	MP0009745_abnormal_behavioral_response	1.01510810
65	MP0001970_abnormal_pain_threshold	1.01235187
66	MP0004924_abnormal_behavior	0.97681211
67	MP0005386_behavior/neurological_phenoty	0.97681211
68	MP0003186_abnormal_redox_activity	0.96076616
69	MP0002210_abnormal_sex_determination	0.94988075
70	MP0005646_abnormal_pituitary_gland	0.94677636
71	MP0005195_abnormal_posterior_eye	0.93097679
72	MP0008789_abnormal_olfactory_epithelium	0.91787869
73	MP0001929_abnormal_gametogenesis	0.90763238
74	MP0002557_abnormal_social/conspecific_i	0.88325281
75	MP0002064_seizures	0.86704336
76	MP0001919_abnormal_reproductive_system	0.86090062
77	MP0000653_abnormal_sex_gland	0.85114553
78	MP0003698_abnormal_male_reproductive	0.82484087
79	MP0001145_abnormal_male_reproductive	0.80591786
80	MP0002067_abnormal_sensory_capabilities	0.79815007
81	MP0002132_abnormal_respiratory_system	0.79647848
82	MP0002751_abnormal_autonomic_nervous	0.78838332
83	MP0001270_distended_abdomen	0.78336868
84	MP0001661_extended_life_span	0.76620989
85	MP0000613_abnormal_salivary_gland	0.75774785
86	MP0003638_abnormal_response/metabolism_	0.74755611
87	MP0004145_abnormal_muscle_electrophysio	0.74406310
88	MP0006035_abnormal_mitochondrial_morpho	0.74219920
89	MP0005266_abnormal_metabolism	0.73477470
90	MP0001501_abnormal_sleep_pattern	0.73393254
91	MP0001756_abnormal_urination	0.71358709
92	MP0008007_abnormal_cellular_replicative	0.70419976
93	MP0005389_reproductive_system_phenotype	0.68563588
94	MP0002938_white_spotting	0.67567908
95	MP0008775_abnormal_heart_ventricle	0.67464685
96	MP0002069_abnormal_eating/drinking_beha	0.66547848
97	MP0006292_abnormal_olfactory_placode	0.66433483
98	MP0005391_vision/eye_phenotype	0.65747372
99	MP0002229_neurodegeneration	0.64713294
100	MP0002233_abnormal_nose_morphology	0.64623343

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased central vision (HP:0007663)	3.97273937
2	Abnormal rod and cone electroretinograms (HP:0008323)	3.81565693
3	Congenital stationary night blindness (HP:0007642)	3.73723109
4	Mitochondrial inheritance (HP:0001427)	3.66406310
5	Acute necrotizing encephalopathy (HP:0006965)	3.63622880
6	Focal motor seizures (HP:0011153)	3.62172455
7	Progressive macrocephaly (HP:0004481)	3.61489426
8	Hepatocellular necrosis (HP:0001404)	3.59861085
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.56209806
10	Absent/shortened dynein arms (HP:0200106)	3.56209806
11	Medial flaring of the eyebrow (HP:0010747)	3.45118737
12	Hepatic necrosis (HP:0002605)	3.44742099
13	Increased CSF lactate (HP:0002490)	3.27490135
14	Abnormality of macular pigmentation (HP:0008002)	3.26773025
15	Hypothermia (HP:0002045)	3.20364746
16	Panhypogammaglobulinemia (HP:0003139)	3.19601723
17	Abnormal mitochondria in muscle tissue (HP:0008316)	3.18194985
18	Acute encephalopathy (HP:0006846)	3.06707063
19	Abnormality of midbrain morphology (HP:0002418)	3.06290544
20	Molar tooth sign on MRI (HP:0002419)	3.06290544
21	Lipid accumulation in hepatocytes (HP:0006561)	3.05113242
22	Atonic seizures (HP:0010819)	2.95026384
23	Chronic hepatic failure (HP:0100626)	2.91484875
24	Pancreatic cysts (HP:0001737)	2.88545616
25	Abnormality of the renal cortex (HP:0011035)	2.88357275
26	Increased hepatocellular lipid droplets (HP:0006565)	2.85959842
27	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.85833866
28	Congenital primary aphakia (HP:0007707)	2.81761083
29	Gait imbalance (HP:0002141)	2.80513914
30	Renal cortical cysts (HP:0000803)	2.79251089
31	Absence seizures (HP:0002121)	2.73622613
32	Abolished electroretinogram (ERG) (HP:0000550)	2.72793835
33	True hermaphroditism (HP:0010459)	2.71980462
34	Dialeptic seizures (HP:0011146)	2.71304112
35	Nephronophthisis (HP:0000090)	2.61935228
36	Increased corneal curvature (HP:0100692)	2.60800580
37	Keratoconus (HP:0000563)	2.60800580
38	Attenuation of retinal blood vessels (HP:0007843)	2.59382188
39	3-Methylglutaconic aciduria (HP:0003535)	2.49524732
40	Abnormality of urine glucose concentration (HP:0011016)	2.49508524
41	Glycosuria (HP:0003076)	2.49508524
42	Increased serum lactate (HP:0002151)	2.46941672
43	Nephrogenic diabetes insipidus (HP:0009806)	2.46741513
44	Central scotoma (HP:0000603)	2.41083870
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.40923430
46	Pancreatic fibrosis (HP:0100732)	2.33552691
47	Hypomagnesemia (HP:0002917)	2.32847023
48	Abnormality of the labia minora (HP:0012880)	2.30747445
49	Thyroiditis (HP:0100646)	2.30167073
50	Hypoplasia of the fovea (HP:0007750)	2.28697792
51	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.28697792
52	Type II lissencephaly (HP:0007260)	2.27363108
53	Exocrine pancreatic insufficiency (HP:0001738)	2.25725712
54	Optic disc pallor (HP:0000543)	2.24955757
55	Respiratory failure (HP:0002878)	2.22191127
56	Abnormality of the renal medulla (HP:0100957)	2.20693862
57	Proximal tubulopathy (HP:0000114)	2.20363709
58	Cerebral edema (HP:0002181)	2.15989721
59	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15450056
60	Abnormal respiratory epithelium morphology (HP:0012253)	2.15450056
61	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.13375346
62	Abnormal pancreas size (HP:0012094)	2.12452414
63	Genital tract atresia (HP:0001827)	2.10483431
64	Renal Fanconi syndrome (HP:0001994)	2.10378376
65	Cone-rod dystrophy (HP:0000548)	2.06980876
66	Pendular nystagmus (HP:0012043)	2.05488082
67	Ketoacidosis (HP:0001993)	2.04286885
68	Rectal fistula (HP:0100590)	2.02873676
69	Rectovaginal fistula (HP:0000143)	2.02873676
70	CNS demyelination (HP:0007305)	2.02773870
71	Constricted visual fields (HP:0001133)	2.02540432
72	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00318182
73	Lactic acidosis (HP:0003128)	1.99648889
74	Agammaglobulinemia (HP:0004432)	1.99099843
75	Hyperglycinuria (HP:0003108)	1.99084105
76	Vaginal atresia (HP:0000148)	1.98492804
77	Abnormality of B cell number (HP:0010975)	1.98455297
78	Progressive microcephaly (HP:0000253)	1.97138311
79	Tubular atrophy (HP:0000092)	1.95525851
80	Generalized aminoaciduria (HP:0002909)	1.94259764
81	Palpitations (HP:0001962)	1.89732373
82	Hyperventilation (HP:0002883)	1.89224918
83	Retinal dysplasia (HP:0007973)	1.87548927
84	Febrile seizures (HP:0002373)	1.86744664
85	Abnormality of the fovea (HP:0000493)	1.86373383
86	Focal seizures (HP:0007359)	1.84794037
87	Limb dystonia (HP:0002451)	1.81906129
88	Arthropathy (HP:0003040)	1.81575899
89	Increased intramyocellular lipid droplets (HP:0012240)	1.81454666
90	Poor coordination (HP:0002370)	1.81294220
91	B lymphocytopenia (HP:0010976)	1.78883355
92	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.78580881
93	Tubulointerstitial abnormality (HP:0001969)	1.78084982
94	Visual hallucinations (HP:0002367)	1.74855217
95	Specific learning disability (HP:0001328)	1.73457637
96	Hypoproteinemia (HP:0003075)	1.73332157
97	Stomach cancer (HP:0012126)	1.73246260
98	Widely spaced teeth (HP:0000687)	1.72578014
99	Fair hair (HP:0002286)	1.68883713
100	Albinism (HP:0001022)	1.68551690

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.59061802
2	WNK3	3.88309581
3	TIE1	3.84824915
4	NUAK1	3.84574057
5	EIF2AK3	3.38840551
6	STK16	2.84303688
7	GRK1	2.21771170
8	ADRBK2	2.21729197
9	MAP4K2	2.01886061
10	LMTK2	2.00223368
11	BMPR1B	1.95118746
12	BCR	1.85243046
13	BCKDK	1.81138536
14	TNIK	1.80744009
15	PINK1	1.72843840
16	TEC	1.71923802
17	MAP3K12	1.67254825
18	CSNK1G1	1.63206042
19	VRK2	1.59398059
20	CDK19	1.58369025
21	CSNK1G3	1.57820551
22	EIF2AK1	1.44254772
23	PHKG1	1.41790372
24	PHKG2	1.41790372
25	BRSK2	1.33946118
26	WNK4	1.31919635
27	CSNK1G2	1.30591627
28	PNCK	1.29159030
29	OXSR1	1.25673260
30	BRD4	1.24993137
31	FGFR2	1.23688319
32	MAP3K4	1.16279695
33	INSRR	1.13396817
34	CSNK1A1L	1.13281395
35	ZAK	1.10092593
36	CAMKK2	1.10046719
37	TRIM28	1.06337303
38	ERBB3	1.05771849
39	MST4	1.05091698
40	STK38L	1.02347210
41	STK39	0.99637386
42	FER	0.98582927
43	PRKCQ	0.94823669
44	PLK2	0.94340035
45	MAPK13	0.93943232
46	MAP2K6	0.93148066
47	BMPR2	0.92507407
48	NLK	0.92501144
49	PAK3	0.91913853
50	PRKCE	0.87948176
51	VRK1	0.87279380
52	TRPM7	0.86027763
53	MKNK1	0.84087665
54	NEK1	0.79470379
55	CDC7	0.75411840
56	DYRK2	0.74042006
57	CDK8	0.73233206
58	PLK3	0.73083089
59	LATS1	0.72977895
60	MAP2K7	0.70726343
61	TXK	0.70201635
62	KIT	0.68640335
63	PRKCG	0.66732110
64	SIK2	0.65726758
65	MAP2K4	0.64355037
66	SYK	0.63292186
67	ATR	0.62301335
68	MAPKAPK3	0.60024462
69	TAF1	0.58778601
70	PRKCI	0.57136644
71	IKBKB	0.56971566
72	PTK2B	0.55847761
73	MAP3K5	0.54258667
74	PASK	0.53884416
75	NTRK3	0.53464065
76	STK3	0.50361058
77	PBK	0.49827424
78	PRKAA1	0.47918920
79	MATK	0.47580589
80	ADRBK1	0.47377110
81	CCNB1	0.44347351
82	CSNK1D	0.43436597
83	TLK1	0.43278663
84	FES	0.42395910
85	PRKG1	0.40725824
86	CSNK1A1	0.40376866
87	CAMK1G	0.40297145
88	FLT3	0.39748093
89	DAPK1	0.39568399
90	MAPKAPK5	0.39287997
91	RPS6KA5	0.37904129
92	TGFBR1	0.37807074
93	PRKACA	0.37280253
94	PIK3CA	0.34036240
95	ITK	0.32591441
96	ATM	0.31381076
97	PRKG2	0.31148354
98	MKNK2	0.30251494
99	SIK3	0.30125874
100	PLK4	0.29590390

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.58592668
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.08726278
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.91302299
4	Protein export_Homo sapiens_hsa03060	2.90719253
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.89346492
6	Sulfur metabolism_Homo sapiens_hsa00920	2.41445837
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.34935231
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.29290806
9	Parkinsons disease_Homo sapiens_hsa05012	2.28459958
10	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.27997368
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.26851352
12	Sulfur relay system_Homo sapiens_hsa04122	1.92287800
13	Proteasome_Homo sapiens_hsa03050	1.84265038
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.62262250
15	RNA degradation_Homo sapiens_hsa03018	1.60178401
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.59792841
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.59339662
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.58219093
19	Butanoate metabolism_Homo sapiens_hsa00650	1.55929895
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.54624347
21	Alzheimers disease_Homo sapiens_hsa05010	1.53202318
22	Huntingtons disease_Homo sapiens_hsa05016	1.51182296
23	Folate biosynthesis_Homo sapiens_hsa00790	1.48517482
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.48211577
25	RNA polymerase_Homo sapiens_hsa03020	1.47768308
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.45586505
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.38788201
28	Caffeine metabolism_Homo sapiens_hsa00232	1.33966382
29	Peroxisome_Homo sapiens_hsa04146	1.33707169
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.33429424
31	Purine metabolism_Homo sapiens_hsa00230	1.33162218
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.32461321
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.32416084
34	Regulation of autophagy_Homo sapiens_hsa04140	1.32247403
35	Basal transcription factors_Homo sapiens_hsa03022	1.31915611
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25541895
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.24288757
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23821824
39	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.16849256
40	Homologous recombination_Homo sapiens_hsa03440	1.16322365
41	Taste transduction_Homo sapiens_hsa04742	1.07315620
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.05861468
43	Retinol metabolism_Homo sapiens_hsa00830	1.05204815
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.05183183
45	Serotonergic synapse_Homo sapiens_hsa04726	0.96766845
46	RNA transport_Homo sapiens_hsa03013	0.96307134
47	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96292563
48	One carbon pool by folate_Homo sapiens_hsa00670	0.95519954
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.95083522
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.93430448
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92337180
52	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.90726769
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88715665
54	Base excision repair_Homo sapiens_hsa03410	0.86680482
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85954135
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.84783688
57	Olfactory transduction_Homo sapiens_hsa04740	0.83069202
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82869118
59	Mismatch repair_Homo sapiens_hsa03430	0.81804135
60	Insulin secretion_Homo sapiens_hsa04911	0.81293817
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.78554225
62	Metabolic pathways_Homo sapiens_hsa01100	0.78253298
63	Circadian rhythm_Homo sapiens_hsa04710	0.77870768
64	GABAergic synapse_Homo sapiens_hsa04727	0.76956756
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76673664
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.76435069
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73038138
68	Morphine addiction_Homo sapiens_hsa05032	0.72176037
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71824632
70	Type I diabetes mellitus_Homo sapiens_hsa04940	0.70512289
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70348065
72	Spliceosome_Homo sapiens_hsa03040	0.70120858
73	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.69507163
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68693499
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67322365
76	Fatty acid elongation_Homo sapiens_hsa00062	0.67132459
77	Propanoate metabolism_Homo sapiens_hsa00640	0.66853239
78	Tryptophan metabolism_Homo sapiens_hsa00380	0.61742250
79	Phenylalanine metabolism_Homo sapiens_hsa00360	0.58973375
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.56719130
81	Nicotine addiction_Homo sapiens_hsa05033	0.56642420
82	Circadian entrainment_Homo sapiens_hsa04713	0.52928792
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52919222
84	Ribosome_Homo sapiens_hsa03010	0.52863490
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.51752317
86	ABC transporters_Homo sapiens_hsa02010	0.49848706
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48091094
88	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47728110
89	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.46900351
90	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46604249
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.46453887
92	Asthma_Homo sapiens_hsa05310	0.42581692
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.42033666
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.41896072
95	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.41035212
96	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.40322202
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.37025569
98	Glutathione metabolism_Homo sapiens_hsa00480	0.36622630
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34438974
100	DNA replication_Homo sapiens_hsa03030	0.33023006

TRIM60P14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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