TRIM60P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of helicase activity (GO:0051095)8.39336548
2pyrimidine dimer repair (GO:0006290)6.50697836
3regulation of cytokine production involved in inflammatory response (GO:1900015)5.18535906
4regulation of histone H3-K9 methylation (GO:0051570)5.05337751
5DNA synthesis involved in DNA repair (GO:0000731)4.71433814
6regulation of MHC class II biosynthetic process (GO:0045346)4.53815815
7positive regulation of leukocyte apoptotic process (GO:2000108)4.41103635
8T cell lineage commitment (GO:0002360)4.31398117
9DNA strand renaturation (GO:0000733)4.16972024
10ovulation from ovarian follicle (GO:0001542)4.12028356
11neutrophil activation involved in immune response (GO:0002283)4.09285771
12positive regulation of gamma-delta T cell activation (GO:0046645)4.03608869
13negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.92169433
14negative regulation of macroautophagy (GO:0016242)3.88129887
15negative regulation of fatty acid biosynthetic process (GO:0045717)3.85726291
16negative regulation of cell aging (GO:0090344)3.84684054
17positive regulation of insulin receptor signaling pathway (GO:0046628)3.84242572
18negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.84196135
19replicative senescence (GO:0090399)3.80302145
20positive T cell selection (GO:0043368)3.76468915
21regulation of B cell receptor signaling pathway (GO:0050855)3.73171385
22regulation of thymocyte apoptotic process (GO:0070243)3.70224476
23single strand break repair (GO:0000012)3.66043447
24necroptotic process (GO:0070266)3.63351242
25positive regulation of granulocyte differentiation (GO:0030854)3.58659498
26mitotic cell cycle arrest (GO:0071850)3.53211725
27positive regulation of T cell apoptotic process (GO:0070234)3.49700264
28immunoglobulin mediated immune response (GO:0016064)3.46903351
29positive regulation of histone methylation (GO:0031062)3.36863036
30negative regulation of peptidyl-lysine acetylation (GO:2000757)3.36751872
31regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.34112869
32regulation of cellular senescence (GO:2000772)3.33573922
33antigen processing and presentation of endogenous antigen (GO:0019883)3.33350426
34mitotic metaphase plate congression (GO:0007080)3.31903496
35positive thymic T cell selection (GO:0045059)3.30050440
36regulation of chromatin silencing (GO:0031935)3.28442715
37positive regulation of cellular response to insulin stimulus (GO:1900078)3.28419269
38negative regulation of smooth muscle cell differentiation (GO:0051151)3.28150125
39ER overload response (GO:0006983)3.23494692
40regulation of interleukin-12 biosynthetic process (GO:0045075)3.23214483
41regulation of cell aging (GO:0090342)3.22262133
42determination of adult lifespan (GO:0008340)3.22208895
43regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.21996518
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.14535795
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14535795
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14535795
47rRNA catabolic process (GO:0016075)3.13171085
48B cell receptor signaling pathway (GO:0050853)3.12855805
49positive regulation of protein oligomerization (GO:0032461)3.11375032
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10467206
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10306540
52hepatocyte apoptotic process (GO:0097284)3.08133478
53regulation of histone H3-K27 methylation (GO:0061085)3.07642945
54negative regulation of cell killing (GO:0031342)3.06673464
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.06673464
56negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.06320063
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05431942
58regulation of bile acid biosynthetic process (GO:0070857)3.05070518
59programmed necrotic cell death (GO:0097300)3.02421493
60neutrophil activation (GO:0042119)3.02265474
61positive regulation of lymphocyte apoptotic process (GO:0070230)3.01944655
62positive regulation of histone deacetylation (GO:0031065)3.00448135
63pre-miRNA processing (GO:0031054)3.00159958
64poly(A)+ mRNA export from nucleus (GO:0016973)2.97737698
65positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94462882
66phosphorylated carbohydrate dephosphorylation (GO:0046838)2.92064084
67inositol phosphate dephosphorylation (GO:0046855)2.92064084
68negative regulation of T-helper cell differentiation (GO:0045623)2.90842434
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.90842434
70regulation of cAMP-dependent protein kinase activity (GO:2000479)2.90781175
71necrotic cell death (GO:0070265)2.87407292
72negative T cell selection (GO:0043383)2.86839901
73positive regulation of cholesterol efflux (GO:0010875)2.85332614
74mitotic G1 DNA damage checkpoint (GO:0031571)2.85077180
75granulocyte activation (GO:0036230)2.84115151
76regulation of interleukin-6 biosynthetic process (GO:0045408)2.83898749
77fatty acid homeostasis (GO:0055089)2.82924460
78mitochondrial calcium ion transport (GO:0006851)2.80662828
79interferon-gamma-mediated signaling pathway (GO:0060333)2.77524837
80regulation of gamma-delta T cell activation (GO:0046643)2.76900789
81negative thymic T cell selection (GO:0045060)2.76814102
82intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.75748586
83B cell mediated immunity (GO:0019724)2.74028501
84DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.73976508
85T cell activation involved in immune response (GO:0002286)2.73517135
86negative regulation of protein acetylation (GO:1901984)2.72727236
87cellular response to type I interferon (GO:0071357)2.72013062
88type I interferon signaling pathway (GO:0060337)2.72013062
89regulation of Golgi to plasma membrane protein transport (GO:0042996)2.71671704
90response to type I interferon (GO:0034340)2.69948053
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69516871
92mitotic G1/S transition checkpoint (GO:0044819)2.69443407
93regulation of interleukin-8 biosynthetic process (GO:0045414)2.69292371
94G1 DNA damage checkpoint (GO:0044783)2.68489865
95positive regulation of protein deacetylation (GO:0090312)2.67067522
96positive regulation of mitochondrial membrane permeability (GO:0035794)2.66694234
97regulation of gamma-delta T cell differentiation (GO:0045586)2.64868851
98cellular response to ionizing radiation (GO:0071479)2.64049406
99positive regulation of macroautophagy (GO:0016239)2.62699852
100neural tube formation (GO:0001841)2.61233366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.28710370
2E2F7_22180533_ChIP-Seq_HELA_Human5.78864115
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.65449304
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.16876354
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.07338086
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00870875
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97472589
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.83138139
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.81732648
10RUNX_20019798_ChIP-Seq_JUKART_Human2.76705763
11GATA1_22025678_ChIP-Seq_K562_Human2.73412478
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.50135456
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30346438
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26836042
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17985195
16MYB_26560356_Chip-Seq_TH2_Human2.13742118
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13650360
18ZNF274_21170338_ChIP-Seq_K562_Hela2.08413251
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07357555
20SPI1_23547873_ChIP-Seq_NB4_Human2.01117969
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00707165
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97944231
23IGF1R_20145208_ChIP-Seq_DFB_Human1.93995122
24SCL_19346495_ChIP-Seq_HPC-7_Human1.80886088
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.77220588
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75068341
27MYC_22102868_ChIP-Seq_BL_Human1.73994082
28MYB_26560356_Chip-Seq_TH1_Human1.73168699
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70783187
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.66786689
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.64164227
32MAF_26560356_Chip-Seq_TH1_Human1.62873813
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58150992
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57618554
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.57284154
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55768485
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54004717
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50074574
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.47481364
40HTT_18923047_ChIP-ChIP_STHdh_Human1.45961060
41VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43783795
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41950005
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41788424
44GATA3_26560356_Chip-Seq_TH2_Human1.41525104
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41272885
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36233996
47GATA3_27048872_Chip-Seq_THYMUS_Human1.35156118
48FOXP3_21729870_ChIP-Seq_TREG_Human1.32794344
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31659992
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31293203
51TAF15_26573619_Chip-Seq_HEK293_Human1.29960857
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24533022
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22769883
54UTX_26944678_Chip-Seq_JUKART_Human1.19399165
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16126824
56PU_27001747_Chip-Seq_BMDM_Mouse1.16043778
57SPI1_23127762_ChIP-Seq_K562_Human1.15977497
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15893360
59VDR_23849224_ChIP-Seq_CD4+_Human1.15834239
60CIITA_25753668_ChIP-Seq_RAJI_Human1.14582825
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.13789784
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13670711
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10815603
64VDR_24763502_ChIP-Seq_THP-1_Human1.07770114
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07412688
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.06408587
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05889584
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.03995050
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03635232
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00853230
71SMRT_27268052_Chip-Seq_Bcells_Human1.00270158
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00088914
73STAT1_20625510_ChIP-Seq_HELA_Human0.99718608
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98864693
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98153781
76SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97971692
77VDR_21846776_ChIP-Seq_THP-1_Human0.97912465
78ETS1_22383799_ChIP-Seq_G1ME_Mouse0.96995698
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95471057
80E2F1_21310950_ChIP-Seq_MCF-7_Human0.94905637
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92456423
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91032670
83EGR1_19374776_ChIP-ChIP_THP-1_Human0.89856017
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88383069
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88279806
86EWS_26573619_Chip-Seq_HEK293_Human0.86929075
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85573005
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.85348045
89GABP_17652178_ChIP-ChIP_JURKAT_Human0.84901236
90CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84129576
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83295509
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82470336
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82451868
94VDR_24787735_ChIP-Seq_THP-1_Human0.81200839
95KDM5A_27292631_Chip-Seq_BREAST_Human0.81034761
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80645908
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78927660
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78756858
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76180592
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76180592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.93946947
2MP0003828_pulmonary_edema2.87690000
3MP0003436_decreased_susceptibility_to2.74178674
4MP0001800_abnormal_humoral_immune2.56429759
5MP0005671_abnormal_response_to2.47865409
6MP0008877_abnormal_DNA_methylation2.26458086
7MP0005387_immune_system_phenotype2.21641477
8MP0001790_abnormal_immune_system2.21641477
9MP0005000_abnormal_immune_tolerance2.15458493
10MP0003763_abnormal_thymus_physiology2.15329858
11MP0008058_abnormal_DNA_repair2.13678298
12MP0002396_abnormal_hematopoietic_system2.03386304
13MP0008057_abnormal_DNA_replication10.3530061
14MP0009785_altered_susceptibility_to1.95960702
15MP0002723_abnormal_immune_serum1.93958314
16MP0002452_abnormal_antigen_presenting1.93362488
17MP0002933_joint_inflammation1.85417825
18MP0002420_abnormal_adaptive_immunity1.84098377
19MP0001819_abnormal_immune_cell1.82153747
20MP0002405_respiratory_system_inflammati1.82004260
21MP0010094_abnormal_chromosome_stability1.73062174
22MP0005025_abnormal_response_to1.66111587
23MP0002148_abnormal_hypersensitivity_rea1.65850411
24MP0005647_abnormal_sex_gland1.65631019
25MP0004808_abnormal_hematopoietic_stem1.64979111
26MP0002254_reproductive_system_inflammat1.63037635
27MP0002102_abnormal_ear_morphology1.62763317
28MP0005220_abnormal_exocrine_pancreas1.62311903
29MP0001873_stomach_inflammation1.58129732
30MP0002009_preneoplasia1.56378362
31MP0000716_abnormal_immune_system1.54846146
32MP0000490_abnormal_crypts_of1.53437819
33MP0002398_abnormal_bone_marrow1.52139147
34MP0002419_abnormal_innate_immunity1.51325751
35MP0000689_abnormal_spleen_morphology1.50858328
36MP0005451_abnormal_body_composition1.48145708
37MP0001853_heart_inflammation1.42292540
38MP0005266_abnormal_metabolism1.42191163
39MP0002722_abnormal_immune_system1.40610366
40MP0010155_abnormal_intestine_physiology1.40030849
41MP0003111_abnormal_nucleus_morphology1.35640636
42MP0000569_abnormal_digit_pigmentation1.33918624
43MP0001849_ear_inflammation1.33582707
44MP0000703_abnormal_thymus_morphology1.31340599
45MP0005187_abnormal_penis_morphology1.26203834
46MP0002429_abnormal_blood_cell1.25536003
47MP0004185_abnormal_adipocyte_glucose1.24704875
48MP0005464_abnormal_platelet_physiology1.19525217
49MP0000685_abnormal_immune_system1.16867945
50MP0003448_altered_tumor_morphology1.15131565
51MP0003303_peritoneal_inflammation1.13287607
52MP0001348_abnormal_lacrimal_gland1.09398025
53MP0002006_tumorigenesis1.09336829
54MP0002166_altered_tumor_susceptibility1.09016671
55MP0002132_abnormal_respiratory_system1.08083033
56MP0001845_abnormal_inflammatory_respons1.07735249
57MP0000465_gastrointestinal_hemorrhage1.07180087
58MP0005075_abnormal_melanosome_morpholog1.07029766
59MP0003077_abnormal_cell_cycle1.06541613
60MP0003724_increased_susceptibility_to1.02842630
61MP0001661_extended_life_span1.02338636
62MP0002160_abnormal_reproductive_system1.01289688
63MP0002019_abnormal_tumor_incidence0.96693468
64MP0003693_abnormal_embryo_hatching0.96266572
65MP0003866_abnormal_defecation0.94983797
66MP0002095_abnormal_skin_pigmentation0.94736798
67MP0004957_abnormal_blastocyst_morpholog0.90211547
68MP0009333_abnormal_splenocyte_physiolog0.88119309
69MP0000747_muscle_weakness0.86756385
70MP0001533_abnormal_skeleton_physiology0.85233873
71MP0009115_abnormal_fat_cell0.84411226
72MP0005310_abnormal_salivary_gland0.84268484
73MP0004381_abnormal_hair_follicle0.80916872
74MP0000015_abnormal_ear_pigmentation0.79874128
75MP0008469_abnormal_protein_level0.78448451
76MP0005379_endocrine/exocrine_gland_phen0.76619676
77MP0000313_abnormal_cell_death0.75886170
78MP0003646_muscle_fatigue0.74607166
79MP0006036_abnormal_mitochondrial_physio0.73997519
80MP0008873_increased_physiological_sensi0.73678045
81MP0003943_abnormal_hepatobiliary_system0.72650609
82MP0008872_abnormal_physiological_respon0.72430250
83MP0005389_reproductive_system_phenotype0.72371015
84MP0005376_homeostasis/metabolism_phenot0.69445935
85MP0005076_abnormal_cell_differentiation0.66880170
86MP0001727_abnormal_embryo_implantation0.66405120
87MP0004484_altered_response_of0.65910180
88MP0005174_abnormal_tail_pigmentation0.65855162
89MP0001663_abnormal_digestive_system0.63102728
90MP0001851_eye_inflammation0.62346473
91MP0002693_abnormal_pancreas_physiology0.62024581
92MP0000627_abnormal_mammary_gland0.61689861
93MP0003936_abnormal_reproductive_system0.60799842
94MP0006082_CNS_inflammation0.60349626
95MP0003959_abnormal_lean_body0.59207424
96MP0000427_abnormal_hair_cycle0.59176056
97MP0003191_abnormal_cellular_cholesterol0.59102050
98MP0008007_abnormal_cellular_replicative0.58760608
99MP0001145_abnormal_male_reproductive0.50632788
100MP0000647_abnormal_sebaceous_gland0.50386520

Predicted human phenotypes

RankGene SetZ-score
1Neoplasm of the adrenal cortex (HP:0100641)5.95552783
2Prostate neoplasm (HP:0100787)5.22885892
3Visual hallucinations (HP:0002367)4.91271471
4Subacute progressive viral hepatitis (HP:0006572)4.28323153
5Abnormality of the prostate (HP:0008775)4.22872880
6Colon cancer (HP:0003003)4.02396399
7Focal motor seizures (HP:0011153)4.01906505
8Viral hepatitis (HP:0006562)3.73016287
9Chronic mucocutaneous candidiasis (HP:0002728)3.64948862
10Recurrent cutaneous fungal infections (HP:0011370)3.64948862
11Chest pain (HP:0100749)3.11998317
12Recurrent fungal infections (HP:0002841)3.05836167
13Abnormality of the parietal bone (HP:0002696)3.03337776
14Abnormality of the lumbar spine (HP:0100712)2.91680884
15Lip pit (HP:0100267)2.86911046
16Missing ribs (HP:0000921)2.82147651
17Broad palm (HP:0001169)2.79401226
18Micronodular cirrhosis (HP:0001413)2.77478950
19Abnormality of male internal genitalia (HP:0000022)2.75893173
20Increased neuronal autofluorescent lipopigment (HP:0002074)2.75108240
21Pancreatic cysts (HP:0001737)2.72843044
22Neoplasm of the adrenal gland (HP:0100631)2.68788064
23Nephroblastoma (Wilms tumor) (HP:0002667)2.66609226
24Panhypogammaglobulinemia (HP:0003139)2.64574738
25Degeneration of the lateral corticospinal tracts (HP:0002314)2.64429666
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.64429666
27Recurrent viral infections (HP:0004429)2.64275021
28Meningitis (HP:0001287)2.59361101
29Beaking of vertebral bodies (HP:0004568)2.58092480
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.57817640
31Posterior subcapsular cataract (HP:0007787)2.56901098
32Periodontitis (HP:0000704)2.56298456
33Broad alveolar ridges (HP:0000187)2.53408017
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53096917
35Acute lymphatic leukemia (HP:0006721)2.48085241
36Embryonal renal neoplasm (HP:0011794)2.45831392
37Cystic hygroma (HP:0000476)2.42594860
38Neonatal hypoglycemia (HP:0001998)2.40873877
39Agammaglobulinemia (HP:0004432)2.40814477
40Increased cerebral lipofuscin (HP:0011813)2.36716379
41Capillary hemangiomas (HP:0005306)2.36505277
42Facial hemangioma (HP:0000329)2.35653693
43Arterial thrombosis (HP:0004420)2.33790744
44Wide intermamillary distance (HP:0006610)2.33526642
45Osteomyelitis (HP:0002754)2.33065767
46Long foot (HP:0001833)2.32390594
47Recurrent abscess formation (HP:0002722)2.30513530
48T lymphocytopenia (HP:0005403)2.28171819
49Amaurosis fugax (HP:0100576)2.27750297
50Autoimmune hemolytic anemia (HP:0001890)2.26953571
51Recurrent skin infections (HP:0001581)2.20011052
52Colitis (HP:0002583)2.18349156
53Abnormality of the pubic bones (HP:0003172)2.17065206
54Recurrent bacterial skin infections (HP:0005406)2.14939136
55Gastrointestinal inflammation (HP:0004386)2.13114203
56Metaphyseal cupping (HP:0003021)2.12770410
57Deep philtrum (HP:0002002)2.12666356
58Abnormality of T cell physiology (HP:0011840)2.09625271
59Abnormality of T cell number (HP:0011839)2.08487623
60Mediastinal lymphadenopathy (HP:0100721)2.07946841
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07215501
62Coarse hair (HP:0002208)2.06697071
63Melanoma (HP:0002861)2.06649166
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04818996
65Polygenic inheritance (HP:0010982)1.98582208
66Abnormality of T cells (HP:0002843)1.98579628
67Encephalitis (HP:0002383)1.98275669
68Recurrent pneumonia (HP:0006532)1.97591513
69Increased density of long bones (HP:0006392)1.95004445
70Lymphoma (HP:0002665)1.94871670
71High anterior hairline (HP:0009890)1.94617489
72Acute myeloid leukemia (HP:0004808)1.93158926
73Inflammation of the large intestine (HP:0002037)1.92831600
74Leiomyosarcoma (HP:0100243)1.92184794
75Uterine leiomyosarcoma (HP:0002891)1.92184794
76Hypoplastic ischia (HP:0003175)1.91487771
77Absence seizures (HP:0002121)1.91264196
78Chronic obstructive pulmonary disease (HP:0006510)1.90541604
79Obstructive lung disease (HP:0006536)1.90541604
80Transitional cell carcinoma of the bladder (HP:0006740)1.86858008
81Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.86323721
82Prominent nose (HP:0000448)1.86007089
83Bladder carcinoma (HP:0002862)1.84710500
84Bladder neoplasm (HP:0009725)1.84710500
85Loss of speech (HP:0002371)1.84165099
86Breast carcinoma (HP:0003002)1.83591091
87Hemoptysis (HP:0002105)1.83584814
88Keratoconjunctivitis (HP:0001096)1.83582887
89Thoracolumbar scoliosis (HP:0002944)1.83301991
90Ureteral obstruction (HP:0006000)1.80146688
91Eczematoid dermatitis (HP:0000976)1.79902120
9211 pairs of ribs (HP:0000878)1.78564490
93Keratoconjunctivitis sicca (HP:0001097)1.77632616
94Spontaneous hematomas (HP:0007420)1.76141567
95Recurrent bronchitis (HP:0002837)1.75196443
96Barrel-shaped chest (HP:0001552)1.74931684
97Progressive inability to walk (HP:0002505)1.73965078
98Chronic diarrhea (HP:0002028)1.70274765
99Myelodysplasia (HP:0002863)1.69557394
100Keratitis (HP:0000491)1.68700507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF17.06553851
2SMG16.90215163
3VRK26.40025145
4NUAK13.67012566
5ACVR1B2.85981828
6MAPKAPK52.79565776
7DYRK32.37864667
8PIK3CG2.37593698
9EEF2K2.11240656
10MUSK2.06798635
11GRK52.00559740
12AKT31.89752406
13VRK11.75359866
14MAP4K11.73012807
15TESK21.59155879
16CDK91.58629178
17MAP3K21.51374033
18MELK1.50697697
19ICK1.46559826
20RIPK41.41339373
21CSNK1A1L1.34140503
22NEK11.34103083
23CSNK1G31.30068556
24DYRK1A1.25274690
25EIF2AK21.21427130
26TGFBR21.21351634
27DAPK11.12042436
28MAPKAPK31.09883651
29CSF1R1.07101185
30BLK1.06511663
31TYK21.00385219
32NME10.93291531
33HIPK20.91984054
34CSNK1G20.90226792
35TXK0.90160053
36TRPM70.83860509
37CSNK1G10.81255752
38FGR0.80920145
39CASK0.78679144
40RPS6KB20.77420258
41SIK30.69926635
42JAK30.69794538
43TNIK0.66886885
44TRIM280.65199450
45MAPK110.64736761
46SYK0.64558179
47CDK70.59490912
48IRAK40.59466636
49CDC70.58486342
50MAP3K100.56133527
51TNK20.53508381
52FRK0.52998944
53PTK2B0.52160276
54BMPR20.50188193
55STK110.47664726
56CDK60.46813514
57JAK10.46235806
58DAPK30.43000980
59CHEK20.42368585
60PNCK0.41807493
61ATR0.41038765
62HCK0.39256483
63RPS6KB10.38477397
64TGFBR10.36760560
65EIF2AK30.36600508
66SRPK10.36331954
67KIT0.35985675
68MAP3K30.35695200
69MAP2K30.34884688
70PLK30.34180397
71NEK90.32170935
72IRAK30.31855603
73PRKCH0.30064683
74LYN0.29675831
75PRPF4B0.28249064
76JAK20.26998554
77BTK0.26257580
78MAPKAPK20.25745146
79FGFR30.25432128
80MARK30.25373316
81CDK190.24354263
82BMX0.24198520
83PRKAA20.21830738
84SGK20.21471606
85STK100.21241505
86CDK40.19317183
87BRAF0.17395380
88ALK0.17259897
89FES0.16810938
90BMPR1B0.15685012
91TEC0.15444895
92GRK60.15076052
93CCNB10.14916394
94LCK0.14771795
95TAOK30.13987697
96TLK10.13253270
97RPS6KC10.12464174
98RPS6KL10.12464174
99CLK10.11354866
100RPS6KA60.11261243

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.38716849
2Allograft rejection_Homo sapiens_hsa053302.98778704
3Autoimmune thyroid disease_Homo sapiens_hsa053202.94410731
4Asthma_Homo sapiens_hsa053102.83712156
5Graft-versus-host disease_Homo sapiens_hsa053322.81008899
6Primary immunodeficiency_Homo sapiens_hsa053402.79942517
7Leishmaniasis_Homo sapiens_hsa051402.53491797
8Staphylococcus aureus infection_Homo sapiens_hsa051502.36372118
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.20564328
10Homologous recombination_Homo sapiens_hsa034402.18054633
11Caffeine metabolism_Homo sapiens_hsa002322.12627918
12Type I diabetes mellitus_Homo sapiens_hsa049402.02936573
13Measles_Homo sapiens_hsa051621.99539081
14Herpes simplex infection_Homo sapiens_hsa051681.88076704
15Antigen processing and presentation_Homo sapiens_hsa046121.75523991
16DNA replication_Homo sapiens_hsa030301.68771598
17Thyroid cancer_Homo sapiens_hsa052161.67063907
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66897886
19Non-small cell lung cancer_Homo sapiens_hsa052231.66815159
20Viral myocarditis_Homo sapiens_hsa054161.62312037
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55278894
22Hematopoietic cell lineage_Homo sapiens_hsa046401.54148524
23Osteoclast differentiation_Homo sapiens_hsa043801.52177224
24B cell receptor signaling pathway_Homo sapiens_hsa046621.50845773
25Non-homologous end-joining_Homo sapiens_hsa034501.43441768
26Chronic myeloid leukemia_Homo sapiens_hsa052201.43164405
27Tuberculosis_Homo sapiens_hsa051521.42775805
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.42078659
29Pancreatic cancer_Homo sapiens_hsa052121.41411690
30Influenza A_Homo sapiens_hsa051641.33055139
31Mismatch repair_Homo sapiens_hsa034301.31142996
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29900565
33Nucleotide excision repair_Homo sapiens_hsa034201.29260279
34Colorectal cancer_Homo sapiens_hsa052101.29248694
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.28070929
36p53 signaling pathway_Homo sapiens_hsa041151.25802455
37Toxoplasmosis_Homo sapiens_hsa051451.23872721
38Fanconi anemia pathway_Homo sapiens_hsa034601.20723172
39T cell receptor signaling pathway_Homo sapiens_hsa046601.12635461
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09895202
41Rheumatoid arthritis_Homo sapiens_hsa053231.09827608
42Hepatitis C_Homo sapiens_hsa051601.08664326
43HTLV-I infection_Homo sapiens_hsa051661.05250333
44Hepatitis B_Homo sapiens_hsa051611.00468568
45RNA degradation_Homo sapiens_hsa030180.99942952
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97356474
47Viral carcinogenesis_Homo sapiens_hsa052030.95878466
48Glioma_Homo sapiens_hsa052140.95675077
49Epstein-Barr virus infection_Homo sapiens_hsa051690.95482519
50Endometrial cancer_Homo sapiens_hsa052130.93534489
51Base excision repair_Homo sapiens_hsa034100.92950893
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91725689
53Small cell lung cancer_Homo sapiens_hsa052220.91190039
54Systemic lupus erythematosus_Homo sapiens_hsa053220.88145731
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86566226
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86214768
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84538346
58MicroRNAs in cancer_Homo sapiens_hsa052060.84323219
59Acute myeloid leukemia_Homo sapiens_hsa052210.84027361
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83098332
61Prostate cancer_Homo sapiens_hsa052150.78353749
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74319487
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.72066800
64Bladder cancer_Homo sapiens_hsa052190.70470668
65Ribosome_Homo sapiens_hsa030100.69744579
66mRNA surveillance pathway_Homo sapiens_hsa030150.68375133
67N-Glycan biosynthesis_Homo sapiens_hsa005100.67235482
68Cell cycle_Homo sapiens_hsa041100.66579124
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63971352
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63368917
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63368019
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61937936
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58886350
74FoxO signaling pathway_Homo sapiens_hsa040680.57911946
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57754015
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56904429
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56442437
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55326407
79mTOR signaling pathway_Homo sapiens_hsa041500.54817464
80Chemokine signaling pathway_Homo sapiens_hsa040620.54213434
81Apoptosis_Homo sapiens_hsa042100.52188770
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.50895148
83Olfactory transduction_Homo sapiens_hsa047400.49738225
84Melanoma_Homo sapiens_hsa052180.49545751
85Renal cell carcinoma_Homo sapiens_hsa052110.49459907
86RNA transport_Homo sapiens_hsa030130.48304148
87Platelet activation_Homo sapiens_hsa046110.45613542
88Phototransduction_Homo sapiens_hsa047440.45404288
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44018391
90Phagosome_Homo sapiens_hsa041450.43933834
91Choline metabolism in cancer_Homo sapiens_hsa052310.39821527
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36876061
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36276315
94MAPK signaling pathway_Homo sapiens_hsa040100.33541607
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30522597
96Inositol phosphate metabolism_Homo sapiens_hsa005620.29785077
97ErbB signaling pathway_Homo sapiens_hsa040120.28136308
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.26305010
99African trypanosomiasis_Homo sapiens_hsa051430.24064022
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23389190

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »