TRIM62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.89046072
2locomotory exploration behavior (GO:0035641)5.60650932
3cerebellar granule cell differentiation (GO:0021707)5.59372552
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.32828727
5sodium ion export (GO:0071436)5.32664272
6synaptic vesicle maturation (GO:0016188)5.18282243
7cerebellar Purkinje cell differentiation (GO:0021702)5.09557143
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.07475081
9positive regulation of synapse maturation (GO:0090129)4.87493657
10layer formation in cerebral cortex (GO:0021819)4.85107558
11synaptic vesicle exocytosis (GO:0016079)4.72997431
12vocalization behavior (GO:0071625)4.68008190
13gamma-aminobutyric acid transport (GO:0015812)4.64942452
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.63624551
15cellular potassium ion homeostasis (GO:0030007)4.61743667
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50857795
17neuronal action potential propagation (GO:0019227)4.42792840
18regulation of synaptic vesicle exocytosis (GO:2000300)4.40807248
19cell differentiation in hindbrain (GO:0021533)4.37391041
20neurotransmitter secretion (GO:0007269)4.33972726
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.29791315
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.25997145
23glutamate receptor signaling pathway (GO:0007215)4.20719880
24glutamate secretion (GO:0014047)4.04581313
25exploration behavior (GO:0035640)3.99380424
26gonadal mesoderm development (GO:0007506)3.97362967
27synaptic transmission, glutamatergic (GO:0035249)3.95620768
28regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.92916782
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.90908691
30regulation of NFAT protein import into nucleus (GO:0051532)3.83689716
31cell communication by electrical coupling (GO:0010644)3.82591301
32axonal fasciculation (GO:0007413)3.81338433
33regulation of synapse maturation (GO:0090128)3.80921631
34negative regulation of cell killing (GO:0031342)3.78730777
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.78730777
36positive regulation by symbiont of host defense response (GO:0052509)3.74702290
37modulation by symbiont of host defense response (GO:0052031)3.74702290
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.74702290
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.74702290
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.74702290
41modulation by symbiont of host immune response (GO:0052553)3.74702290
42regulation of synaptic vesicle transport (GO:1902803)3.71640861
43protein localization to synapse (GO:0035418)3.68441524
44long-term memory (GO:0007616)3.66137449
45neuromuscular process controlling posture (GO:0050884)3.64692854
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.61512372
47regulation of glutamate receptor signaling pathway (GO:1900449)3.53788564
48neuron cell-cell adhesion (GO:0007158)3.51392453
49synaptic vesicle docking involved in exocytosis (GO:0016081)3.49414009
50neurotransmitter-gated ion channel clustering (GO:0072578)3.48781402
51neuron-neuron synaptic transmission (GO:0007270)3.48049845
52dendrite morphogenesis (GO:0048813)3.47327353
53intracellular estrogen receptor signaling pathway (GO:0030520)3.45930929
54leukocyte aggregation (GO:0070486)3.45476716
55cell migration in hindbrain (GO:0021535)3.43438384
56synaptic vesicle endocytosis (GO:0048488)3.43275210
57potassium ion homeostasis (GO:0055075)3.42532812
58neuron recognition (GO:0008038)3.39662071
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39195591
60neuromuscular process controlling balance (GO:0050885)3.37438443
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.36944844
62potassium ion import (GO:0010107)3.36742363
63regulation of synapse structural plasticity (GO:0051823)3.36169563
64negative regulation of erythrocyte differentiation (GO:0045647)3.35891859
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.34165638
66regulation of neuronal synaptic plasticity (GO:0048168)3.31835187
67neurotransmitter transport (GO:0006836)3.28536103
68protein localization to endosome (GO:0036010)3.27780481
69positive regulation of gamma-delta T cell activation (GO:0046645)3.23232288
70cellular sodium ion homeostasis (GO:0006883)3.20205782
71transmission of nerve impulse (GO:0019226)3.20087623
72adult walking behavior (GO:0007628)3.17308462
73dendritic spine morphogenesis (GO:0060997)3.16242986
74membrane depolarization during action potential (GO:0086010)3.15962279
75proline transport (GO:0015824)3.14396044
76response to muramyl dipeptide (GO:0032495)3.14179086
77regulation of long-term neuronal synaptic plasticity (GO:0048169)3.13761093
78establishment of nucleus localization (GO:0040023)3.12826066
79positive regulation of potassium ion transmembrane transport (GO:1901381)3.11323809
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.10519869
81innervation (GO:0060384)3.10339242
82auditory behavior (GO:0031223)3.08892534
83regulation of neurotransmitter secretion (GO:0046928)3.06855332
84regulation of defense response to virus by virus (GO:0050690)3.05960426
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05880664
86negative regulation of microtubule polymerization (GO:0031115)3.04850589
87mating behavior (GO:0007617)3.04817649
88positive regulation of membrane potential (GO:0045838)3.04648822
89glycine transport (GO:0015816)3.04093793
90regulation of neurotransmitter levels (GO:0001505)3.02897896
91positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.02582928
92negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02215358
93neuronal ion channel clustering (GO:0045161)3.01324161
94synapse assembly (GO:0007416)2.99198917
95response to auditory stimulus (GO:0010996)2.97009313
96membrane repolarization (GO:0086009)2.96754770
97response to laminar fluid shear stress (GO:0034616)2.96406313
98prepulse inhibition (GO:0060134)2.95862055
99thymic T cell selection (GO:0045061)2.93975869
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93960363
101regulation of postsynaptic membrane potential (GO:0060078)2.93680651
102detection of other organism (GO:0098543)2.92259629
103histone H3-K36 demethylation (GO:0070544)2.92060512
104regulation of ARF protein signal transduction (GO:0032012)2.91249245
105T cell selection (GO:0045058)2.89903424
106negative regulation of cAMP-mediated signaling (GO:0043951)2.89630609
107regulation of synaptic transmission, glutamatergic (GO:0051966)2.88157595
108interferon-gamma secretion (GO:0072643)2.87978445
109detection of bacterium (GO:0016045)2.86534018
110negative regulation of glial cell proliferation (GO:0060253)2.84516700
111antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84161637
1123-UTR-mediated mRNA stabilization (GO:0070935)2.83858997
113long term synaptic depression (GO:0060292)2.83851710
114protein kinase C signaling (GO:0070528)2.82383800
115regulation of gamma-delta T cell activation (GO:0046643)2.81262666
116membrane hyperpolarization (GO:0060081)2.80462412
117activation of protein kinase A activity (GO:0034199)2.80191899
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80108616
119histone lysine demethylation (GO:0070076)2.80065227
120regulation of neurotransmitter transport (GO:0051588)2.79703702
121tolerance induction (GO:0002507)2.79614633
122postsynaptic membrane organization (GO:0001941)2.79613239
123negative thymic T cell selection (GO:0045060)2.78329261
124regulation of vesicle fusion (GO:0031338)2.78021138
125membrane depolarization (GO:0051899)2.77824945
126regulation of voltage-gated calcium channel activity (GO:1901385)2.77536871
127synapse organization (GO:0050808)2.77436315
128mechanosensory behavior (GO:0007638)2.77230972
129negative T cell selection (GO:0043383)2.74523875
130neuromuscular process (GO:0050905)2.72851001
131C4-dicarboxylate transport (GO:0015740)2.72375194
132cerebellar Purkinje cell layer development (GO:0021680)2.71507447
133regulation of synaptic plasticity (GO:0048167)2.71128933
134positive regulation of synapse assembly (GO:0051965)2.70293433
135histone demethylation (GO:0016577)2.69122262
136macrophage activation involved in immune response (GO:0002281)2.69104747
137long-term synaptic potentiation (GO:0060291)2.66151256
138substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.65832108
139regulation of T-helper 2 cell differentiation (GO:0045628)2.63895100
140protein dealkylation (GO:0008214)2.62905513
141protein demethylation (GO:0006482)2.62905513
142regulation of histone H3-K27 methylation (GO:0061085)2.61964616
143histone H3-K4 trimethylation (GO:0080182)2.61424142
144regulation of gamma-delta T cell differentiation (GO:0045586)2.60486911
145signal complex assembly (GO:0007172)2.59122926
146stress granule assembly (GO:0034063)2.56955732
147positive T cell selection (GO:0043368)2.55993850
148positive regulation of Cdc42 GTPase activity (GO:0043089)2.53909583
149positive regulation of CREB transcription factor activity (GO:0032793)2.52383545
150regulation of ARF GTPase activity (GO:0032312)2.50997454
151histone H4 deacetylation (GO:0070933)2.50817320
152antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49994776
153negative regulation of histone methylation (GO:0031061)2.47817938
154regulation of early endosome to late endosome transport (GO:2000641)2.47206221
155modulation by virus of host process (GO:0019054)2.45668654
156antigen processing and presentation of endogenous antigen (GO:0019883)2.45277927
157adherens junction assembly (GO:0034333)2.42449932
158phosphatidylinositol dephosphorylation (GO:0046856)2.42307114
159response to peptidoglycan (GO:0032494)2.41034262
160histone H3-K4 methylation (GO:0051568)2.40788408
161positive regulation of humoral immune response (GO:0002922)2.40752617
162negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.38426795
163positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.38087643
164positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.37761293
165histone H3-K9 modification (GO:0061647)2.36982953
166positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.35881838
167cellular extravasation (GO:0045123)2.33691553
168cell-cell junction maintenance (GO:0045217)2.33285400
169regulation of DNA methylation (GO:0044030)2.32936983
170phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.32491386
171focal adhesion assembly (GO:0048041)2.29477090
172cell-substrate adherens junction assembly (GO:0007045)2.29477090
173activation of Rac GTPase activity (GO:0032863)2.28136992
174neutrophil activation (GO:0042119)2.27627252
175semaphorin-plexin signaling pathway (GO:0071526)2.26056829
176regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.25483340
177positive regulation of blood vessel endothelial cell migration (GO:0043536)2.25061146
178response to host defenses (GO:0052200)2.24877917
179response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.24877917
180response to host (GO:0075136)2.24877917
181stress fiber assembly (GO:0043149)2.24864988
182protein targeting to plasma membrane (GO:0072661)2.24673778
183regulation of water loss via skin (GO:0033561)2.23377386
184establishment of skin barrier (GO:0061436)2.22884492
185virion assembly (GO:0019068)2.21737070
186response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.21034816
187response to host immune response (GO:0052572)2.21034816
188mannose metabolic process (GO:0006013)2.20483523
189activated T cell proliferation (GO:0050798)2.19156246
190regulation of B cell receptor signaling pathway (GO:0050855)2.17666754
191regulation of interferon-beta biosynthetic process (GO:0045357)2.17312054
192modulation by symbiont of host cellular process (GO:0044068)2.16793640
193regulation of lipid kinase activity (GO:0043550)2.15670138
194positive thymic T cell selection (GO:0045059)2.15090167

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.09339984
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10866555
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01941780
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.95366252
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.95366252
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93537749
7VDR_21846776_ChIP-Seq_THP-1_Human2.93302680
8DROSHA_22980978_ChIP-Seq_HELA_Human2.92329809
9MYC_22102868_ChIP-Seq_BL_Human2.83541084
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.82420339
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77720317
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.73512331
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73337260
14TCF7_22412390_ChIP-Seq_EML_Mouse2.70436272
15* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.63586782
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.61285876
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61141150
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.59703749
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59657609
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.59073909
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.57235100
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55981855
23REST_21632747_ChIP-Seq_MESCs_Mouse2.50939002
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50487867
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.49124971
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.49058673
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.47077433
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42812382
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36712676
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.35780333
31* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.34297101
32GBX2_23144817_ChIP-Seq_PC3_Human2.25716702
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16464286
34RARB_27405468_Chip-Seq_BRAIN_Mouse2.01066831
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98405170
36* REST_18959480_ChIP-ChIP_MESCs_Mouse1.98177662
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97146109
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.94839394
39MAF_26560356_Chip-Seq_TH1_Human1.90105775
40VDR_24763502_ChIP-Seq_THP-1_Human1.89649352
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.88553166
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87565158
43UTX_26944678_Chip-Seq_JUKART_Human1.86907580
44* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85094523
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.82840119
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82285543
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77009671
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.76655445
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74768580
50* KDM2B_26808549_Chip-Seq_K562_Human1.74241670
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.72617428
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68284169
53MAF_26560356_Chip-Seq_TH2_Human1.67373779
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62465530
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60030691
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59026558
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57208278
58AR_21572438_ChIP-Seq_LNCaP_Human1.54835409
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54547766
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53562337
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53295885
62* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51689980
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.51528830
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49541653
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48137958
66* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46646154
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45486685
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.42865246
69SMC4_20622854_ChIP-Seq_HELA_Human1.39037011
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38442049
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37886486
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37423282
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.36021324
74* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35854706
75RUNX_20019798_ChIP-Seq_JUKART_Human1.35176544
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34124657
77SPI1_23127762_ChIP-Seq_K562_Human1.33884515
78P68_20966046_ChIP-Seq_HELA_Human1.33550081
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33018928
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32779102
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30916661
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30150391
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28699280
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28663747
85AR_19668381_ChIP-Seq_PC3_Human1.27720536
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26835275
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26766305
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.26696532
89IGF1R_20145208_ChIP-Seq_DFB_Human1.26627112
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26601698
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26558508
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26381198
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25592100
94* CREB1_26743006_Chip-Seq_LNCaP_Human1.23017726
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.22503070
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22487082
97FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22204740
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21089888
99SMAD4_21799915_ChIP-Seq_A2780_Human1.20780744
100* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20534328
101* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19769334
102RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19030848
103* TET1_21451524_ChIP-Seq_MESCs_Mouse1.17513334
104ZNF274_21170338_ChIP-Seq_K562_Hela1.17357513
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17256072
106* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15066873
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15047404
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14501161
109KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13727973
110CIITA_25753668_ChIP-Seq_RAJI_Human1.13715528
111* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12325114
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11599255
113* SOX2_21211035_ChIP-Seq_LN229_Gbm1.10925515
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10044619
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.09679726
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06922281
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06673535
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05567233
119* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05001875
120SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04622467
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04481728
122SMAD3_21741376_ChIP-Seq_ESCs_Human1.04387117
123* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04258427
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03224307
125GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02215192
126SMAD4_21741376_ChIP-Seq_HESCs_Human1.01324042
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00719226
128* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00230792
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99807151
130SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98754063
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98623895
132BCOR_27268052_Chip-Seq_Bcells_Human0.98026577
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97672405
134YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97570156
135AHR_22903824_ChIP-Seq_MCF-7_Human0.97470492
136ELF1_20517297_ChIP-Seq_JURKAT_Human0.96841096
137MYB_26560356_Chip-Seq_TH1_Human0.96563540
138RUNX1_27514584_Chip-Seq_MCF-7_Human0.96453564
139FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96422241
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96310307
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.96149043
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95249378
143* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94801115
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94644621
145SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.94499413
146VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93995010
147* KDM2B_26808549_Chip-Seq_JURKAT_Human0.93948839
148SMAD_19615063_ChIP-ChIP_OVARY_Human0.93550420
149RNF2_27304074_Chip-Seq_NSC_Mouse0.93435193
150* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93201399
151STAT3_23295773_ChIP-Seq_U87_Human0.92422202
152AR_25329375_ChIP-Seq_VCAP_Human0.92342258
153TP53_22127205_ChIP-Seq_IMR90_Human0.92050872
154SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91901717
155RXR_22108803_ChIP-Seq_LS180_Human0.91131260
156PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91033196
157CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90637705
158* KDM2B_26808549_Chip-Seq_DND41_Human0.90130299
159CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88453415
160* LXR_22292898_ChIP-Seq_THP-1_Human0.87691629
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.84870167
162* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84573756
163RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84204199
164SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83497094
165ISL1_27105846_Chip-Seq_CPCs_Mouse0.82918717
166NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81730473
167CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81052555
168P300_19829295_ChIP-Seq_ESCs_Human0.79612259
169CTCF_27219007_Chip-Seq_Bcells_Human0.78467225
170TCF4_23295773_ChIP-Seq_U87_Human0.78138344
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.77633812
172OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76107832
173ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75213642

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.13823832
2MP0009046_muscle_twitch4.00125764
3MP0003635_abnormal_synaptic_transmissio3.74225158
4MP0003705_abnormal_hypodermis_morpholog3.51779584
5MP0005423_abnormal_somatic_nervous3.50331470
6MP0008260_abnormal_autophagy3.27812264
7MP0003436_decreased_susceptibility_to3.15973919
8MP0004270_analgesia3.13954910
9MP0008569_lethality_at_weaning2.97848189
10MP0002064_seizures2.80851256
11MP0009745_abnormal_behavioral_response2.77181499
12MP0002063_abnormal_learning/memory/cond2.77049967
13MP0002184_abnormal_innervation2.71241022
14MP0003172_abnormal_lysosome_physiology2.69896563
15MP0009278_abnormal_bone_marrow2.63535745
16MP0004381_abnormal_hair_follicle2.50481848
17MP0002734_abnormal_mechanical_nocicepti2.50153224
18MP0002272_abnormal_nervous_system2.49270528
19MP0003303_peritoneal_inflammation2.39650341
20MP0004858_abnormal_nervous_system2.37825052
21MP0001486_abnormal_startle_reflex2.35059154
22MP0002572_abnormal_emotion/affect_behav2.34996583
23MP0000778_abnormal_nervous_system2.30621225
24MP0004145_abnormal_muscle_electrophysio2.28678390
25MP0002796_impaired_skin_barrier2.27751635
26MP0003763_abnormal_thymus_physiology2.24191514
27MP0004885_abnormal_endolymph2.14130551
28MP0001968_abnormal_touch/_nociception2.13276770
29MP0002067_abnormal_sensory_capabilities2.09027518
30MP0002557_abnormal_social/conspecific_i2.06760631
31MP0003880_abnormal_central_pattern2.02208089
32MP0004947_skin_inflammation2.02015820
33MP0003300_gastrointestinal_ulcer1.99261251
34MP0003329_amyloid_beta_deposits1.94138898
35MP0002733_abnormal_thermal_nociception1.93371644
36MP0001440_abnormal_grooming_behavior1.92111861
37MP0000955_abnormal_spinal_cord1.91412524
38MP0003122_maternal_imprinting1.90279707
39MP0001188_hyperpigmentation1.86517783
40MP0004811_abnormal_neuron_physiology1.82391186
41MP0001501_abnormal_sleep_pattern1.82205017
42MP0002909_abnormal_adrenal_gland1.76917441
43MP0002735_abnormal_chemical_nociception1.74677346
44MP0005645_abnormal_hypothalamus_physiol1.73183094
45MP0003566_abnormal_cell_adhesion1.70771373
46MP0001970_abnormal_pain_threshold1.70381575
47MP0005058_abnormal_lysosome_morphology1.68998481
48MP0005451_abnormal_body_composition1.66085189
49MP0001502_abnormal_circadian_rhythm1.66013079
50MP0002736_abnormal_nociception_after1.63281667
51MP0001984_abnormal_olfaction1.62702462
52MP0005076_abnormal_cell_differentiation1.60063052
53MP0005409_darkened_coat_color1.57344225
54MP0002882_abnormal_neuron_morphology1.55557463
55MP0003183_abnormal_peptide_metabolism1.55060454
56MP0005501_abnormal_skin_physiology1.54979945
57MP0005000_abnormal_immune_tolerance1.52347189
58MP0009780_abnormal_chondrocyte_physiolo1.48956514
59MP0005075_abnormal_melanosome_morpholog1.48188429
60MP0002822_catalepsy1.48162199
61MP0005257_abnormal_intraocular_pressure1.48039965
62MP0000569_abnormal_digit_pigmentation1.46925741
63MP0003283_abnormal_digestive_organ1.46427172
64MP0003632_abnormal_nervous_system1.45052025
65MP0003453_abnormal_keratinocyte_physiol1.43235882
66MP0004742_abnormal_vestibular_system1.43174809
67MP0002066_abnormal_motor_capabilities/c1.42931574
68MP0000733_abnormal_muscle_development1.42462085
69MP0005386_behavior/neurological_phenoty1.39812610
70MP0004924_abnormal_behavior1.39812610
71MP0005248_abnormal_Harderian_gland1.38822927
72MP0003091_abnormal_cell_migration1.38131552
73MP0001849_ear_inflammation1.37127604
74MP0006276_abnormal_autonomic_nervous1.36480311
75MP0003191_abnormal_cellular_cholesterol1.33896839
76MP0008995_early_reproductive_senescence1.33832204
77MP0002152_abnormal_brain_morphology1.33277048
78MP0002420_abnormal_adaptive_immunity1.32002403
79MP0002419_abnormal_innate_immunity1.31828414
80MP0000703_abnormal_thymus_morphology1.29252702
81MP0001819_abnormal_immune_cell1.29246492
82MP0001800_abnormal_humoral_immune1.29037262
83MP0003787_abnormal_imprinting1.28474656
84MP0005499_abnormal_olfactory_system1.27542622
85MP0005394_taste/olfaction_phenotype1.27542622
86MP0000858_altered_metastatic_potential1.27449723
87MP0003879_abnormal_hair_cell1.23389572
88MP0002653_abnormal_ependyma_morphology1.22605366
89MP0002723_abnormal_immune_serum1.21986419
90MP0003724_increased_susceptibility_to1.21832817
91MP0009840_abnormal_foam_cell1.20920083
92MP0004142_abnormal_muscle_tone1.20143152
93MP0001346_abnormal_lacrimal_gland1.19929971
94MP0002398_abnormal_bone_marrow1.18214413
95MP0005397_hematopoietic_system_phenotyp1.15721197
96MP0001545_abnormal_hematopoietic_system1.15721197
97MP0005187_abnormal_penis_morphology1.13036007
98MP0001533_abnormal_skeleton_physiology1.11851171
99MP0003631_nervous_system_phenotype1.11057924
100MP0003866_abnormal_defecation1.10867892
101MP0005025_abnormal_response_to1.10372855
102MP0002452_abnormal_antigen_presenting1.09813768
103MP0000465_gastrointestinal_hemorrhage1.09800794
104MP0000015_abnormal_ear_pigmentation1.08284896
105MP0002089_abnormal_postnatal_growth/wei1.08205432
106MP0001851_eye_inflammation1.08067565
107MP0003279_aneurysm1.07445301
108MP0004233_abnormal_muscle_weight1.07097655
109MP0000716_abnormal_immune_system1.06399222
110MP0003633_abnormal_nervous_system1.04996844
111MP0009333_abnormal_splenocyte_physiolog1.03498417
112MP0001542_abnormal_bone_strength1.01093172
113MP0000631_abnormal_neuroendocrine_gland1.01088696
114MP0002998_abnormal_bone_remodeling0.99585398
115MP0003634_abnormal_glial_cell0.98018347
116MP0008874_decreased_physiological_sensi0.97489076
117MP0004264_abnormal_extraembryonic_tissu0.96014251
118MP0002638_abnormal_pupillary_reflex0.95818198
119MP0005646_abnormal_pituitary_gland0.95367909
120MP0002069_abnormal_eating/drinking_beha0.95345650
121MP0010234_abnormal_vibrissa_follicle0.95086055
122MP0001986_abnormal_taste_sensitivity0.94927951
123MP0005621_abnormal_cell_physiology0.94662885
124MP0003861_abnormal_nervous_system0.92881908
125MP0000685_abnormal_immune_system0.92365644
126MP0002098_abnormal_vibrissa_morphology0.90623135
127MP0008961_abnormal_basal_metabolism0.90464092
128MP0003121_genomic_imprinting0.90444763
129MP0002405_respiratory_system_inflammati0.88811455
130MP0002752_abnormal_somatic_nervous0.88532002
131MP0002722_abnormal_immune_system0.88076511
132MP0001790_abnormal_immune_system0.87955550
133MP0005387_immune_system_phenotype0.87955550
134MP0001299_abnormal_eye_distance/0.87476626
135MP0000377_abnormal_hair_follicle0.87190750
136MP0002877_abnormal_melanocyte_morpholog0.86442199
137MP0003828_pulmonary_edema0.86177771
138MP0003137_abnormal_impulse_conducting0.84491882
139MP0000579_abnormal_nail_morphology0.84081706
140MP0001216_abnormal_epidermal_layer0.82893649
141MP0000013_abnormal_adipose_tissue0.81907653
142MP0000534_abnormal_ureter_morphology0.81743796
143MP0006072_abnormal_retinal_apoptosis0.80648106
144MP0000604_amyloidosis0.80497757
145MP0005623_abnormal_meninges_morphology0.80494739
146MP0002229_neurodegeneration0.79002336
147MP0002429_abnormal_blood_cell0.78568790
148MP0001270_distended_abdomen0.78171564
149MP0005551_abnormal_eye_electrophysiolog0.77982621
150MP0001963_abnormal_hearing_physiology0.77686062
151MP0003690_abnormal_glial_cell0.75920497
152MP0000920_abnormal_myelination0.75208230
153MP0002090_abnormal_vision0.75144418
154MP0008872_abnormal_physiological_respon0.74440253
155MP0000537_abnormal_urethra_morphology0.74196758
156MP0000689_abnormal_spleen_morphology0.73815185
157MP0001348_abnormal_lacrimal_gland0.73232735
158MP0005671_abnormal_response_to0.72763390
159MP0000470_abnormal_stomach_morphology0.72679085
160MP0004085_abnormal_heartbeat0.72473795
161MP0000767_abnormal_smooth_muscle0.72471902
162MP0002060_abnormal_skin_morphology0.72462484
163MP0001177_atelectasis0.72178902
164MP0008789_abnormal_olfactory_epithelium0.72059244
165MP0002249_abnormal_larynx_morphology0.71208017
166MP0009931_abnormal_skin_appearance0.70948254
167MP0010769_abnormal_survival0.70534893
168MP0004510_myositis0.70240981
169MP0001943_abnormal_respiration0.68968152
170MP0000751_myopathy0.68561926
171MP0005390_skeleton_phenotype0.68360255
172MP0002751_abnormal_autonomic_nervous0.68237055
173MP0000490_abnormal_crypts_of0.67922915
174MP0002396_abnormal_hematopoietic_system0.67245009
175MP0010768_mortality/aging0.66789187
176MP0010386_abnormal_urinary_bladder0.65899663
177MP0002082_postnatal_lethality0.65744299
178MP0010770_preweaning_lethality0.65744299

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)5.52234392
2Progressive cerebellar ataxia (HP:0002073)5.48207274
3Visual hallucinations (HP:0002367)5.40250622
4Myokymia (HP:0002411)4.60912295
5Focal motor seizures (HP:0011153)4.44993354
6Focal seizures (HP:0007359)4.26954016
7Atonic seizures (HP:0010819)3.76158351
8Eczematoid dermatitis (HP:0000976)3.71305252
9Genetic anticipation (HP:0003743)3.69955773
10Gaze-evoked nystagmus (HP:0000640)3.64019037
11Hemiplegia (HP:0002301)3.54229702
12Increased IgE level (HP:0003212)3.49404509
13Epileptic encephalopathy (HP:0200134)3.48095591
14Impaired smooth pursuit (HP:0007772)3.45879118
15Obstructive sleep apnea (HP:0002870)3.42915023
16Abnormal eating behavior (HP:0100738)3.38331013
17Febrile seizures (HP:0002373)3.36726393
18Scanning speech (HP:0002168)3.34226298
19Broad face (HP:0000283)3.27606938
20Dysmetric saccades (HP:0000641)3.20227628
21Truncal ataxia (HP:0002078)3.14054623
22Supranuclear gaze palsy (HP:0000605)3.11370490
23Long palpebral fissure (HP:0000637)3.10709731
24Abnormality of ocular smooth pursuit (HP:0000617)3.10027551
25Dysdiadochokinesis (HP:0002075)3.09286194
26Peripheral hypomyelination (HP:0007182)3.08867948
27Broad-based gait (HP:0002136)3.00372706
28Intention tremor (HP:0002080)2.99633933
29Hemiparesis (HP:0001269)2.99324942
30Absence seizures (HP:0002121)2.97737356
31Agitation (HP:0000713)2.92238125
32Depression (HP:0000716)2.91258324
33Ankle clonus (HP:0011448)2.75869604
34Amyotrophic lateral sclerosis (HP:0007354)2.72827242
35Hand muscle atrophy (HP:0009130)2.69865517
36Megalencephaly (HP:0001355)2.66532222
37Abnormality of the lower motor neuron (HP:0002366)2.66493365
38Dysmetria (HP:0001310)2.65703974
39Abnormality of binocular vision (HP:0011514)2.64570115
40Diplopia (HP:0000651)2.64570115
41Thin bony cortex (HP:0002753)2.64118127
42Annular pancreas (HP:0001734)2.57291828
43Mutism (HP:0002300)2.56118780
44Polyphagia (HP:0002591)2.54448317
45Dialeptic seizures (HP:0011146)2.53624340
46Pointed chin (HP:0000307)2.49912224
47Abnormality of macrophages (HP:0004311)2.49704396
48Ventricular fibrillation (HP:0001663)2.46812739
49Generalized tonic-clonic seizures (HP:0002069)2.46065769
50Syringomyelia (HP:0003396)2.46041763
51Spinal cord lesions (HP:0100561)2.46041763
52Tetraplegia (HP:0002445)2.42842917
53Recurrent bacterial skin infections (HP:0005406)2.39173753
54Insomnia (HP:0100785)2.36783204
55Failure to thrive in infancy (HP:0001531)2.36229093
56Status epilepticus (HP:0002133)2.35530628
57Postural tremor (HP:0002174)2.34569079
58Split foot (HP:0001839)2.33399510
59Anomalous pulmonary venous return (HP:0010772)2.31214790
60Spastic gait (HP:0002064)2.31000426
61Poor eye contact (HP:0000817)2.30227155
62Disproportionate tall stature (HP:0001519)2.29864735
63Neurofibrillary tangles (HP:0002185)2.29553526
64Cerebral aneurysm (HP:0004944)2.27962560
65Genu recurvatum (HP:0002816)2.27722421
66Recurrent abscess formation (HP:0002722)2.27573640
67Neoplasm of the heart (HP:0100544)2.25476974
68Renal cell carcinoma (HP:0005584)2.23943631
69Abnormality of the pulmonary veins (HP:0011718)2.23774788
70Hypoventilation (HP:0002791)2.22022880
71Spinal canal stenosis (HP:0003416)2.21683746
72Hyperacusis (HP:0010780)2.19807001
73Impaired social interactions (HP:0000735)2.19620143
74Abnormal social behavior (HP:0012433)2.19620143
75Loss of speech (HP:0002371)2.19585841
76Abnormality of the corticospinal tract (HP:0002492)2.18564119
77Subacute progressive viral hepatitis (HP:0006572)2.18472381
78Anxiety (HP:0000739)2.18039298
79Macroorchidism (HP:0000053)2.17635116
80Stereotypic behavior (HP:0000733)2.17572457
81Upper limb amyotrophy (HP:0009129)2.14151311
82Distal upper limb amyotrophy (HP:0007149)2.14151311
83Shallow orbits (HP:0000586)2.12089994
84Postural instability (HP:0002172)2.10723966
85Asymmetry of the thorax (HP:0001555)2.10454027
86Urinary bladder sphincter dysfunction (HP:0002839)2.09455306
87Limb ataxia (HP:0002070)2.08265745
88Narrow nasal bridge (HP:0000446)2.06193216
89Elfin facies (HP:0004428)2.04445737
90Pustule (HP:0200039)2.02410990
91Papilloma (HP:0012740)2.02392216
92Verrucae (HP:0200043)2.02392216
93Deep palmar crease (HP:0006191)2.02356459
94Impaired vibration sensation in the lower limbs (HP:0002166)1.99393635
95Neuronal loss in central nervous system (HP:0002529)1.99203188
96Spontaneous hematomas (HP:0007420)1.97637987
97Stomatitis (HP:0010280)1.96809664
98Overriding aorta (HP:0002623)1.96037119
99Abnormality of saccadic eye movements (HP:0000570)1.95526706
100Horizontal nystagmus (HP:0000666)1.92710846
101EEG with generalized epileptiform discharges (HP:0011198)1.92700742
102Ocular albinism (HP:0001107)1.92009940
103Hypsarrhythmia (HP:0002521)1.91813173
104Specific learning disability (HP:0001328)1.91583929
105Lower limb asymmetry (HP:0100559)1.90517674
106Cerebral inclusion bodies (HP:0100314)1.90076265
107Apathy (HP:0000741)1.89105417
108Papilledema (HP:0001085)1.88625713
109Drooling (HP:0002307)1.87534501
110Excessive salivation (HP:0003781)1.87534501
111Micronodular cirrhosis (HP:0001413)1.87397242
112Abnormality of the columella (HP:0009929)1.86934821
113Epileptiform EEG discharges (HP:0011182)1.86602902
114Diminished motivation (HP:0000745)1.86339558
115Thick nail (HP:0001805)1.85711473
116Urinary urgency (HP:0000012)1.85414398
117Renovascular hypertension (HP:0100817)1.84957530
118Anteriorly placed anus (HP:0001545)1.84180527
119Clonus (HP:0002169)1.84180116
120Germ cell neoplasia (HP:0100728)1.83765807
121Heterotopia (HP:0002282)1.83422762
122Gait ataxia (HP:0002066)1.83209020
123Absent speech (HP:0001344)1.82901149
124Trigonocephaly (HP:0000243)1.82699476
125Renal duplication (HP:0000075)1.81763771
126Decreased motor nerve conduction velocity (HP:0003431)1.81377402
127Torticollis (HP:0000473)1.81263857
128Sleep apnea (HP:0010535)1.80475551
129Gait imbalance (HP:0002141)1.80124899
130Slow saccadic eye movements (HP:0000514)1.79852088
131Cellulitis (HP:0100658)1.79123968
132Hypoplastic nipples (HP:0002557)1.77793355
133Abnormality of the intervertebral disk (HP:0005108)1.77627405
134Progressive inability to walk (HP:0002505)1.77250133
135Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77045860
136Lip pit (HP:0100267)1.76722700
137Limb dystonia (HP:0002451)1.76385963
138Termporal pattern (HP:0011008)1.75708949
139Insidious onset (HP:0003587)1.75708949
140Broad metatarsal (HP:0001783)1.75162176
141Urticaria (HP:0001025)1.74677254
142Amblyopia (HP:0000646)1.74403619
143Focal dystonia (HP:0004373)1.74322515
144Increased variability in muscle fiber diameter (HP:0003557)1.72918373
145Morphological abnormality of the pyramidal tract (HP:0002062)1.72167266
146Myositis (HP:0100614)1.71214157
147Rapidly progressive (HP:0003678)1.71185048
148Aneurysm (HP:0002617)1.70944456
149Distal lower limb amyotrophy (HP:0008944)1.70266457
150Gastrointestinal inflammation (HP:0004386)1.69692829
151Dilatation of the ascending aorta (HP:0005111)1.69496746
152Overgrowth (HP:0001548)1.69185338
153Malnutrition (HP:0004395)1.68575403
154Spina bifida occulta (HP:0003298)1.67954875
155Hypercortisolism (HP:0001578)1.67564045
156Abnormality of nail color (HP:0100643)1.67348533
157Hemorrhage of the eye (HP:0011885)1.67141594
158Spondylolisthesis (HP:0003302)1.65935924
159Onion bulb formation (HP:0003383)1.65648278
160Uterine leiomyosarcoma (HP:0002891)1.64789362
161Leiomyosarcoma (HP:0100243)1.64789362
162Long eyelashes (HP:0000527)1.64344472
163Thickened helices (HP:0000391)1.63878652
164Premature rupture of membranes (HP:0001788)1.63193047
165Abnormality of the fingertips (HP:0001211)1.62566578
166Hyperparathyroidism (HP:0000843)1.60880404
167Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.60365619
168Gastrointestinal infarctions (HP:0005244)1.59071754
169Arterial tortuosity (HP:0005116)1.58683226
170Neonatal hypoglycemia (HP:0001998)1.57689341
171Supernumerary nipples (HP:0002558)1.57550380
172Peritonitis (HP:0002586)1.56922959
173Supernumerary ribs (HP:0005815)1.55412869
174Distal sensory impairment (HP:0002936)1.53735930
175Premature loss of primary teeth (HP:0006323)1.53413741
176Progressive sensorineural hearing impairment (HP:0000408)1.52917680
177Transitional cell carcinoma of the bladder (HP:0006740)1.52855445
178Mediastinal lymphadenopathy (HP:0100721)1.51460506
179Abnormal cortical bone morphology (HP:0003103)1.50557544
180Protrusio acetabuli (HP:0003179)1.50464980
181Iris hypopigmentation (HP:0007730)1.49792358
182Gingivitis (HP:0000230)1.49734850
183Sepsis (HP:0100806)1.49411218
184Mitral regurgitation (HP:0001653)1.48594924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK13.40506429
2MAP3K93.33496316
3MARK13.12036834
4NTRK33.10916011
5MAP3K42.86976176
6CAMKK22.82283173
7PAK62.76508245
8CDK122.64717977
9SIK12.56251018
10NTRK22.52341128
11MINK12.48734225
12MAP4K12.46157526
13MAP2K72.03688534
14CAMKK12.02795438
15EPHA32.02515064
16ERN11.94453368
17SMG11.90397852
18PRKD21.76116971
19DAPK21.71663751
20GRK61.71274817
21WNK11.69521014
22MAP3K111.68566750
23SGK4941.66432216
24SGK2231.66432216
25SGK21.66033175
26PKN21.65239257
27KSR21.64765610
28IRAK41.63584133
29TYRO31.63300084
30KSR11.62445191
31MAP2K41.61714817
32CDK191.56232962
33MAP2K31.54687660
34TESK21.53216498
35EEF2K1.49291374
36MAP3K61.48990809
37ICK1.46986208
38RIPK41.45443919
39SGK31.39532483
40STK381.39213645
41CDK51.35787785
42SIK21.32805712
43FGFR41.30631633
44MAP3K31.28421505
45SIK31.24817486
46TESK11.24632875
47UHMK11.24433563
48ZAP701.21920785
49NTRK11.21624956
50PHKG21.18547505
51PHKG11.18547505
52PRKCH1.17373691
53PRKD31.15489280
54TYK21.15066781
55CAMK1G1.12772326
56ALK1.11106018
57PRKCG1.10594138
58CSK1.09842127
59MAPK131.08402913
60DYRK1B1.07748719
61PRPF4B1.04901271
62MAP3K71.00916525
63ERBB31.00684795
64TRIB30.97877709
65DYRK1A0.97217572
66TNIK0.96868393
67CDK180.96453241
68CDK150.94917460
69STK110.94719797
70RPS6KA20.94292102
71PNCK0.93451213
72DMPK0.90017218
73CDK140.88740041
74RET0.88081974
75BRAF0.87742853
76LRRK20.87713465
77TAOK20.86122736
78MAP3K10.84302610
79ERBB20.83538065
80CDK11A0.81475534
81MTOR0.81334646
82LMTK20.80956757
83MAP3K120.80793212
84HIPK20.80737707
85PTK60.80581668
86FES0.79085024
87CAMK10.78935572
88CAMK40.78330204
89ARAF0.78049586
90CDC42BPA0.77061038
91BLK0.76873784
92MAP3K140.76439275
93MARK30.75484846
94ROCK20.74720950
95MAP3K20.73692768
96PTK20.73503107
97CDK90.73339911
98BRD40.72061609
99PLK20.71203646
100FGR0.70922141
101MAP3K50.70119421
102MARK20.69142476
103PAK30.68789627
104PIM20.67932822
105GRK50.67722991
106SGK10.67197014
107BTK0.65677412
108AKT30.64158964
109HCK0.64101993
110FER0.63382219
111MAP3K100.63034288
112TTN0.62776101
113CAMK1D0.62766724
114MAPK70.62273515
115JAK30.61202989
116IKBKE0.60589221
117PDK10.57990653
118PDPK10.57856556
119TBK10.57614717
120CAMK2G0.57144608
121IRAK20.56566270
122CHUK0.56209392
123EPHB10.52939080
124RPS6KA30.52731502
125PRKCZ0.52541093
126PRKCE0.52250249
127CAMK2A0.52231201
128JAK10.52223214
129CASK0.52132935
130PDGFRA0.51407097
131LATS20.51030716
132CAMK2B0.50767296
133FYN0.49986801
134MAPK120.48169324
135CSNK1G20.47475943
136PRKD10.47297943
137SCYL20.47178840
138TAOK10.46622604
139NEK60.45149908
140IRAK10.44684585
141PAK40.44636905
142PRKG10.44528293
143MAPK100.44410909
144TNK20.44268815
145CDK70.43610785
146RPS6KC10.43610136
147RPS6KL10.43610136
148LCK0.42529243
149DYRK20.42214762
150MUSK0.42183236
151MAPK90.42027741
152OXSR10.41382451
153MAP3K130.41185713
154PINK10.40126665
155ROCK10.39886526
156MAPK80.39802677
157EPHB20.38633540
158ITK0.38311502
159SRC0.36015057
160DAPK10.35260480

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.44506585
2Synaptic vesicle cycle_Homo sapiens_hsa047212.75570049
3Glutamatergic synapse_Homo sapiens_hsa047242.55520864
4GABAergic synapse_Homo sapiens_hsa047272.50938315
5Circadian entrainment_Homo sapiens_hsa047132.46305289
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45845468
7Long-term potentiation_Homo sapiens_hsa047202.29395395
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17826732
9Morphine addiction_Homo sapiens_hsa050322.15806494
10Acute myeloid leukemia_Homo sapiens_hsa052212.11570990
11Long-term depression_Homo sapiens_hsa047302.04046801
12Taste transduction_Homo sapiens_hsa047421.97881037
13Salivary secretion_Homo sapiens_hsa049701.94703123
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.84165719
15Amphetamine addiction_Homo sapiens_hsa050311.83345640
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81487201
17Dopaminergic synapse_Homo sapiens_hsa047281.80383230
18Chronic myeloid leukemia_Homo sapiens_hsa052201.80190658
19Insulin secretion_Homo sapiens_hsa049111.78390341
20B cell receptor signaling pathway_Homo sapiens_hsa046621.74139230
21Gastric acid secretion_Homo sapiens_hsa049711.73030203
22Olfactory transduction_Homo sapiens_hsa047401.69263526
23Osteoclast differentiation_Homo sapiens_hsa043801.68146934
24Cholinergic synapse_Homo sapiens_hsa047251.65146521
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57744230
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56835934
27Notch signaling pathway_Homo sapiens_hsa043301.54386267
28T cell receptor signaling pathway_Homo sapiens_hsa046601.52308393
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52202123
30Pancreatic cancer_Homo sapiens_hsa052121.51513461
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49042037
32Type II diabetes mellitus_Homo sapiens_hsa049301.42680268
33Oxytocin signaling pathway_Homo sapiens_hsa049211.41797246
34Cocaine addiction_Homo sapiens_hsa050301.39085481
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38555081
36Axon guidance_Homo sapiens_hsa043601.35599807
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33783837
38Hepatitis B_Homo sapiens_hsa051611.30841881
39Renin secretion_Homo sapiens_hsa049241.30724158
40Gap junction_Homo sapiens_hsa045401.28729291
41cAMP signaling pathway_Homo sapiens_hsa040241.28331918
42Estrogen signaling pathway_Homo sapiens_hsa049151.26742926
43Serotonergic synapse_Homo sapiens_hsa047261.26483057
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25216096
45Thyroid cancer_Homo sapiens_hsa052161.21857014
46GnRH signaling pathway_Homo sapiens_hsa049121.21704378
47Calcium signaling pathway_Homo sapiens_hsa040201.17163597
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17031011
49Prostate cancer_Homo sapiens_hsa052151.13400635
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13133268
51FoxO signaling pathway_Homo sapiens_hsa040681.12461030
52Shigellosis_Homo sapiens_hsa051311.11850681
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11077012
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11058633
55Melanogenesis_Homo sapiens_hsa049161.07976357
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05813991
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05382679
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.05238325
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03241587
60Hepatitis C_Homo sapiens_hsa051601.02944704
61Pancreatic secretion_Homo sapiens_hsa049721.01830491
62Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01415532
63TNF signaling pathway_Homo sapiens_hsa046681.00115463
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00009876
65Measles_Homo sapiens_hsa051620.99675520
66ErbB signaling pathway_Homo sapiens_hsa040120.99204013
67Thyroid hormone synthesis_Homo sapiens_hsa049180.98628942
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.97614908
69Glioma_Homo sapiens_hsa052140.93743042
70Apoptosis_Homo sapiens_hsa042100.91546873
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90993142
72Endometrial cancer_Homo sapiens_hsa052130.89509707
73Toxoplasmosis_Homo sapiens_hsa051450.89359231
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89166312
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.88565972
76Other glycan degradation_Homo sapiens_hsa005110.86334554
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85030574
78Tuberculosis_Homo sapiens_hsa051520.85007113
79Bladder cancer_Homo sapiens_hsa052190.83276732
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.82595345
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.81106649
82Small cell lung cancer_Homo sapiens_hsa052220.80699329
83Choline metabolism in cancer_Homo sapiens_hsa052310.80416005
84Dorso-ventral axis formation_Homo sapiens_hsa043200.79956437
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78932945
86MAPK signaling pathway_Homo sapiens_hsa040100.78573965
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78536755
88Salmonella infection_Homo sapiens_hsa051320.78399456
89Dilated cardiomyopathy_Homo sapiens_hsa054140.78258442
90Circadian rhythm_Homo sapiens_hsa047100.78046105
91Platelet activation_Homo sapiens_hsa046110.77751672
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.77388544
93Inositol phosphate metabolism_Homo sapiens_hsa005620.77350093
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77001110
95MicroRNAs in cancer_Homo sapiens_hsa052060.76441644
96Influenza A_Homo sapiens_hsa051640.74756034
97Phagosome_Homo sapiens_hsa041450.72710070
98Amoebiasis_Homo sapiens_hsa051460.71841807
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71654895
100Oocyte meiosis_Homo sapiens_hsa041140.71046926
101Hedgehog signaling pathway_Homo sapiens_hsa043400.70994217
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70051330
103Focal adhesion_Homo sapiens_hsa045100.69791950
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69699272
105Adherens junction_Homo sapiens_hsa045200.69561346
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68351239
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.68194918
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67725939
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67078880
110mTOR signaling pathway_Homo sapiens_hsa041500.67038841
111Colorectal cancer_Homo sapiens_hsa052100.66507406
112Basal cell carcinoma_Homo sapiens_hsa052170.65563072
113Leishmaniasis_Homo sapiens_hsa051400.65061721
114Collecting duct acid secretion_Homo sapiens_hsa049660.64249135
115Cardiac muscle contraction_Homo sapiens_hsa042600.63209208
116Pathways in cancer_Homo sapiens_hsa052000.62896114
117Melanoma_Homo sapiens_hsa052180.62513131
118Wnt signaling pathway_Homo sapiens_hsa043100.62076789
119Endocytosis_Homo sapiens_hsa041440.61998956
120Epstein-Barr virus infection_Homo sapiens_hsa051690.61707278
121HIF-1 signaling pathway_Homo sapiens_hsa040660.61222824
122Hippo signaling pathway_Homo sapiens_hsa043900.61154817
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.60939165
124AMPK signaling pathway_Homo sapiens_hsa041520.60352417
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59602237
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59515034
127Rap1 signaling pathway_Homo sapiens_hsa040150.59493858
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57313200
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57121600
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56631783
131Prolactin signaling pathway_Homo sapiens_hsa049170.55929423
132Bile secretion_Homo sapiens_hsa049760.54697975
133Type I diabetes mellitus_Homo sapiens_hsa049400.54488708
134VEGF signaling pathway_Homo sapiens_hsa043700.54018614
135Proteoglycans in cancer_Homo sapiens_hsa052050.53750942
136Renal cell carcinoma_Homo sapiens_hsa052110.53295026
137Vibrio cholerae infection_Homo sapiens_hsa051100.52928111
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49641328
139Non-small cell lung cancer_Homo sapiens_hsa052230.49269014
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48524545
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48210877
142Chemokine signaling pathway_Homo sapiens_hsa040620.44995845
143Ras signaling pathway_Homo sapiens_hsa040140.44984212
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44422059
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43773758
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43348810
147Alcoholism_Homo sapiens_hsa050340.42337900
148Insulin signaling pathway_Homo sapiens_hsa049100.41794403
149Glucagon signaling pathway_Homo sapiens_hsa049220.40215425
150Nitrogen metabolism_Homo sapiens_hsa009100.38707073

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