ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of thymocyte apoptotic process (GO:0070244)	9.60823052
2	V(D)J recombination (GO:0033151)	7.52717441
3	cellular response to ethanol (GO:0071361)	6.39293551
4	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	6.17538385
5	response to hydroperoxide (GO:0033194)	5.74437097
6	regulation of thymocyte apoptotic process (GO:0070243)	5.66937698
7	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.50980758
8	regulation of retinoic acid receptor signaling pathway (GO:0048385)	4.93487549
9	oocyte development (GO:0048599)	4.70894244
10	negative regulation of T cell apoptotic process (GO:0070233)	4.56157062
11	musculoskeletal movement (GO:0050881)	4.29629328
12	multicellular organismal movement (GO:0050879)	4.29629328
13	T cell differentiation in thymus (GO:0033077)	4.26784019
14	male meiosis I (GO:0007141)	4.23246399
15	reflex (GO:0060004)	4.21734685
16	regulation of RIG-I signaling pathway (GO:0039535)	4.19528515
17	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	4.18160366
18	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	4.18160366
19	regulation of uterine smooth muscle contraction (GO:0070472)	4.13441646
20	tachykinin receptor signaling pathway (GO:0007217)	4.13082119
21	negative regulation of sodium ion transport (GO:0010766)	4.11736117
22	negative regulation of Ras GTPase activity (GO:0034261)	4.07984902
23	negative regulation of smooth muscle cell differentiation (GO:0051151)	4.03695942
24	multicellular organism reproduction (GO:0032504)	4.01136742
25	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	4.00496054
26	somatic cell DNA recombination (GO:0016444)	4.00496054
27	T cell lineage commitment (GO:0002360)	3.97386307
28	histone lysine demethylation (GO:0070076)	3.96898558
29	synaptonemal complex organization (GO:0070193)	3.94487759
30	somatic diversification of immune receptors (GO:0002200)	3.92805486
31	positive regulation of meiosis (GO:0045836)	3.88565546
32	gonadal mesoderm development (GO:0007506)	3.86569237
33	histone demethylation (GO:0016577)	3.84200557
34	regulation of posttranscriptional gene silencing (GO:0060147)	3.83830443
35	regulation of gene silencing by miRNA (GO:0060964)	3.83830443
36	regulation of gene silencing by RNA (GO:0060966)	3.83830443
37	single fertilization (GO:0007338)	3.75933965
38	synaptonemal complex assembly (GO:0007130)	3.71322912
39	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.70229220
40	protein K48-linked deubiquitination (GO:0071108)	3.67615650
41	B cell differentiation (GO:0030183)	3.67061597
42	positive regulation of meiotic cell cycle (GO:0051446)	3.64282375
43	regulation of neurotransmitter uptake (GO:0051580)	3.51545032
44	poly(A)+ mRNA export from nucleus (GO:0016973)	3.51177489
45	aggressive behavior (GO:0002118)	3.50528397
46	positive regulation of histone H3-K4 methylation (GO:0051571)	3.39313602
47	hepatocyte differentiation (GO:0070365)	3.34996726
48	neutrophil activation involved in immune response (GO:0002283)	3.34530846
49	indolalkylamine metabolic process (GO:0006586)	3.32807054
50	pseudouridine synthesis (GO:0001522)	3.29977715
51	meiosis I (GO:0007127)	3.27288707
52	oligosaccharide catabolic process (GO:0009313)	3.26544865
53	negative regulation of interleukin-17 production (GO:0032700)	3.25959347
54	seminiferous tubule development (GO:0072520)	3.24744369
55	protein dealkylation (GO:0008214)	3.24739079
56	protein demethylation (GO:0006482)	3.24739079
57	labyrinthine layer development (GO:0060711)	3.22036266
58	regulation of ruffle assembly (GO:1900027)	3.20766237
59	protein K63-linked deubiquitination (GO:0070536)	3.19819707
60	regulation of histone H3-K9 methylation (GO:0051570)	3.10729268
61	T cell homeostasis (GO:0043029)	3.10658476
62	cilium or flagellum-dependent cell motility (GO:0001539)	3.05743389
63	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.03294620
64	positive regulation of SMAD protein import into nucleus (GO:0060391)	2.98981458
65	B cell proliferation (GO:0042100)	2.97084987
66	indole-containing compound catabolic process (GO:0042436)	2.96929418
67	indolalkylamine catabolic process (GO:0046218)	2.96929418
68	tryptophan catabolic process (GO:0006569)	2.96929418
69	regulation of acrosome reaction (GO:0060046)	2.95492943
70	positive regulation of renal sodium excretion (GO:0035815)	2.93818109
71	positive regulation of toll-like receptor signaling pathway (GO:0034123)	2.93621865
72	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.93465757
73	glycine transport (GO:0015816)	2.88489107
74	synaptic transmission, dopaminergic (GO:0001963)	2.86680669
75	histone monoubiquitination (GO:0010390)	2.84764611
76	positive regulation of response to biotic stimulus (GO:0002833)	2.84494448
77	regulation of establishment of cell polarity (GO:2000114)	2.83688043
78	fertilization (GO:0009566)	2.79630445
79	cytokine biosynthetic process (GO:0042089)	2.78000995
80	regulation of female receptivity (GO:0045924)	2.77679986
81	G-protein coupled receptor internalization (GO:0002031)	2.76673238
82	regulation of female gonad development (GO:2000194)	2.76291990
83	fat-soluble vitamin catabolic process (GO:0042363)	2.70930963
84	vitamin catabolic process (GO:0009111)	2.70930963
85	regulation of defense response to virus by host (GO:0050691)	2.69903857
86	interleukin-6-mediated signaling pathway (GO:0070102)	2.69798398
87	resolution of meiotic recombination intermediates (GO:0000712)	2.67127469
88	male meiosis (GO:0007140)	2.64296952
89	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.63996423
90	tryptophan metabolic process (GO:0006568)	2.63983067
91	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.62485768
92	kynurenine metabolic process (GO:0070189)	2.61903878
93	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.61077380
94	regulation of T cell apoptotic process (GO:0070232)	2.60332062
95	purine-containing compound salvage (GO:0043101)	2.58437298
96	monoubiquitinated protein deubiquitination (GO:0035520)	2.57618926
97	behavioral response to cocaine (GO:0048148)	2.50426038
98	B cell activation (GO:0042113)	2.50046497
99	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.48954699
100	histone H3-K9 demethylation (GO:0033169)	10.6577335

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.82684189
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.50294978
3	VDR_22108803_ChIP-Seq_LS180_Human	2.95950314
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.85845822
5	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.80551640
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.80248565
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.80096244
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.56427814
9	IRF1_19129219_ChIP-ChIP_H3396_Human	2.38435787
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.38357875
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.36402515
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.33564281
13	P300_19829295_ChIP-Seq_ESCs_Human	2.15057218
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13980635
15	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.10771737
16	EWS_26573619_Chip-Seq_HEK293_Human	2.06161033
17	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.97850769
18	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.97435002
19	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.90530662
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85289721
21	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.85039616
22	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.69201969
23	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.69201969
24	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.69201969
25	SMRT_27268052_Chip-Seq_Bcells_Human	1.67461670
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67271187
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.64542779
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62659583
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.58411577
30	TCF4_23295773_ChIP-Seq_U87_Human	1.57799787
31	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.56957973
32	STAT3_23295773_ChIP-Seq_U87_Human	1.56196298
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.56065757
34	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.54273753
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.53113734
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.51117833
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50726313
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49615130
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.47860459
40	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.43730033
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42242405
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41248767
43	TCF4_22108803_ChIP-Seq_LS180_Human	1.40367653
44	AR_25329375_ChIP-Seq_VCAP_Human	1.40228288
45	SCL_19346495_ChIP-Seq_HPC-7_Human	1.39743267
46	GF1_26923725_Chip-Seq_HPCs_Mouse	1.39284383
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39089968
48	RXR_22108803_ChIP-Seq_LS180_Human	1.37310957
49	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.37074390
50	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.33441731
51	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.32937109
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31663482
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31630330
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31630330
55	MYB_26560356_Chip-Seq_TH2_Human	1.31457437
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30728587
57	VDR_24787735_ChIP-Seq_THP-1_Human	1.29430157
58	TAF15_26573619_Chip-Seq_HEK293_Human	1.29350557
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.28949770
60	ZNF274_21170338_ChIP-Seq_K562_Hela	1.28475916
61	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.26782878
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.25048750
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24766348
64	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.21919408
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.19750521
66	CBP_21632823_ChIP-Seq_H3396_Human	1.19697585
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19502873
68	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.19248734
69	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.18706572
70	FUS_26573619_Chip-Seq_HEK293_Human	1.18172244
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17561643
72	GATA3_26560356_Chip-Seq_TH1_Human	1.17185683
73	RUNX_20019798_ChIP-Seq_JUKART_Human	1.16980997
74	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16855215
75	AR_21572438_ChIP-Seq_LNCaP_Human	1.16514483
76	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.15427485
77	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14857461
78	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14786624
79	CDX2_22108803_ChIP-Seq_LS180_Human	1.14409609
80	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.14312047
81	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.14165066
82	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.12875069
83	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.12839626
84	TP53_22573176_ChIP-Seq_HFKS_Human	1.12535058
85	GATA3_27048872_Chip-Seq_THYMUS_Human	1.12413563
86	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09271185
87	KDM2B_26808549_Chip-Seq_REH_Human	1.08064183
88	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.07345059
89	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06777182
90	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03869600
91	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03869600
92	CJUN_26792858_Chip-Seq_BT549_Human	1.03809729
93	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.02669928
94	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02622693
95	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02204056
96	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01702532
97	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99870188
98	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.98767419
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96355342
100	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.95784414

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002132_abnormal_respiratory_system	5.70083996
2	MP0005451_abnormal_body_composition	5.25174715
3	MP0009278_abnormal_bone_marrow	4.82278432
4	MP0002876_abnormal_thyroid_physiology	4.05289812
5	MP0005397_hematopoietic_system_phenotyp	2.99972153
6	MP0001545_abnormal_hematopoietic_system	2.99972153
7	MP0002166_altered_tumor_susceptibility	2.90693531
8	MP0000462_abnormal_digestive_system	2.67259173
9	MP0003283_abnormal_digestive_organ	2.62200301
10	MP0000685_abnormal_immune_system	2.58935471
11	MP0005671_abnormal_response_to	2.46571217
12	MP0006292_abnormal_olfactory_placode	2.39950814
13	MP0010094_abnormal_chromosome_stability	2.39943138
14	MP0004947_skin_inflammation	2.39502543
15	MP0009785_altered_susceptibility_to	2.26586715
16	MP0000569_abnormal_digit_pigmentation	2.18602587
17	MP0001835_abnormal_antigen_presentation	2.13908019
18	MP0001849_ear_inflammation	2.13405495
19	MP0002006_tumorigenesis	2.13129497
20	MP0005410_abnormal_fertilization	2.07625984
21	MP0002148_abnormal_hypersensitivity_rea	1.97238250
22	MP0000470_abnormal_stomach_morphology	1.90299129
23	MP0002095_abnormal_skin_pigmentation	1.82507471
24	MP0005360_urolithiasis	1.82430279
25	MP0005387_immune_system_phenotype	1.73529263
26	MP0001790_abnormal_immune_system	1.73529263
27	MP0000427_abnormal_hair_cycle	1.67577509
28	MP0003879_abnormal_hair_cell	1.58945833
29	MP0005171_absent_coat_pigmentation	1.57416022
30	MP0003950_abnormal_plasma_membrane	1.57174165
31	MP0001800_abnormal_humoral_immune	1.48828958
32	MP0008872_abnormal_physiological_respon	1.43081539
33	MP0001879_abnormal_lymphatic_vessel	1.41671065
34	MP0001501_abnormal_sleep_pattern	1.41559104
35	MP0003693_abnormal_embryo_hatching	1.41263695
36	MP0002933_joint_inflammation	1.36730884
37	MP0001485_abnormal_pinna_reflex	1.35064696
38	MP0006276_abnormal_autonomic_nervous	1.33050130
39	MP0006072_abnormal_retinal_apoptosis	1.32808208
40	MP0010155_abnormal_intestine_physiology	1.32258492
41	MP0002160_abnormal_reproductive_system	1.31353335
42	MP0009840_abnormal_foam_cell	1.29381946
43	MP0008004_abnormal_stomach_pH	1.26557436
44	MP0005670_abnormal_white_adipose	1.22179626
45	MP0001440_abnormal_grooming_behavior	1.21041062
46	MP0009046_muscle_twitch	1.16084700
47	MP0005464_abnormal_platelet_physiology	1.06415328
48	MP0003806_abnormal_nucleotide_metabolis	1.05809127
49	MP0000678_abnormal_parathyroid_gland	1.05066126
50	MP0005000_abnormal_immune_tolerance	1.00312317
51	MP0004742_abnormal_vestibular_system	0.98606414
52	MP0005646_abnormal_pituitary_gland	0.97253399
53	MP0004043_abnormal_pH_regulation	0.95483119
54	MP0002102_abnormal_ear_morphology	0.94748310
55	MP0002452_abnormal_antigen_presenting	0.94297160
56	MP0008057_abnormal_DNA_replication	0.93268898
57	MP0001929_abnormal_gametogenesis	0.92605008
58	MP0005220_abnormal_exocrine_pancreas	0.89056023
59	MP0002723_abnormal_immune_serum	0.88210533
60	MP0003718_maternal_effect	0.86721865
61	MP0003136_yellow_coat_color	0.85089411
62	MP0002405_respiratory_system_inflammati	0.83886570
63	MP0005647_abnormal_sex_gland	0.82939041
64	MP0002398_abnormal_bone_marrow	0.82453285
65	MP0001765_abnormal_ion_homeostasis	0.81955316
66	MP0008877_abnormal_DNA_methylation	0.81459030
67	MP0000049_abnormal_middle_ear	0.80001719
68	MP0005551_abnormal_eye_electrophysiolog	0.79260461
69	MP0000689_abnormal_spleen_morphology	0.79223267
70	MP0001944_abnormal_pancreas_morphology	0.79148737
71	MP0004084_abnormal_cardiac_muscle	0.78627761
72	MP0003866_abnormal_defecation	0.78197118
73	MP0002229_neurodegeneration	0.78086291
74	MP0009745_abnormal_behavioral_response	0.77793841
75	MP0001819_abnormal_immune_cell	0.77615692
76	MP0002693_abnormal_pancreas_physiology	0.77599639
77	MP0002722_abnormal_immune_system	0.77309525
78	MP0002420_abnormal_adaptive_immunity	0.77138036
79	MP0003119_abnormal_digestive_system	0.77067522
80	MP0000631_abnormal_neuroendocrine_gland	0.76454480
81	MP0000716_abnormal_immune_system	0.76192092
82	MP0005025_abnormal_response_to	0.75739774
83	MP0001666_abnormal_nutrient_absorption	0.74667886
84	MP0000230_abnormal_systemic_arterial	0.74634151
85	MP0001243_abnormal_dermal_layer	0.72393450
86	MP0005377_hearing/vestibular/ear_phenot	0.71881904
87	MP0003878_abnormal_ear_physiology	0.71881904
88	MP0005253_abnormal_eye_physiology	0.71103360
89	MP0004142_abnormal_muscle_tone	0.70342871
90	MP0001664_abnormal_digestion	0.70189323
91	MP0000383_abnormal_hair_follicle	0.68190987
92	MP0001663_abnormal_digestive_system	0.67721244
93	MP0002998_abnormal_bone_remodeling	0.65444321
94	MP0001529_abnormal_vocalization	0.64437351
95	MP0000703_abnormal_thymus_morphology	0.63659632
96	MP0008875_abnormal_xenobiotic_pharmacok	0.63490966
97	MP0001963_abnormal_hearing_physiology	0.63068788
98	MP0002419_abnormal_innate_immunity	0.62631436
99	MP0004808_abnormal_hematopoietic_stem	0.61706892
100	MP0002210_abnormal_sex_determination	0.60776663

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe combined immunodeficiency (HP:0004430)	9.33489279
2	Hypoproteinemia (HP:0003075)	8.80334453
3	Thyroiditis (HP:0100646)	8.69611727
4	Combined immunodeficiency (HP:0005387)	7.79829837
5	T lymphocytopenia (HP:0005403)	6.57923657
6	Eosinophilia (HP:0001880)	5.85687194
7	Abnormality of T cell number (HP:0011839)	5.51475337
8	Erythroderma (HP:0001019)	5.17048482
9	Granulocytopenia (HP:0001913)	4.64562278
10	Abnormality of eosinophils (HP:0001879)	4.17588733
11	Recurrent viral infections (HP:0004429)	4.14966113
12	IgG deficiency (HP:0004315)	4.09138664
13	Agammaglobulinemia (HP:0004432)	3.68869162
14	Recurrent fungal infections (HP:0002841)	3.62161551
15	Aplasia/Hypoplasia of the thymus (HP:0010515)	3.50396553
16	Abnormality of T cells (HP:0002843)	3.24276241
17	Leukocytosis (HP:0001974)	3.21270345
18	Meningitis (HP:0001287)	2.98965386
19	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.97933526
20	Sepsis (HP:0100806)	2.75076519
21	Abnormality of the thymus (HP:0000777)	2.72237963
22	Chronic sinusitis (HP:0011109)	2.57572616
23	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.57487635
24	Reticulocytopenia (HP:0001896)	2.49899797
25	Increased cerebral lipofuscin (HP:0011813)	2.43935039
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.30693315
27	Congenital sensorineural hearing impairment (HP:0008527)	2.28637154
28	Recurrent bronchitis (HP:0002837)	2.10041208
29	Premature ovarian failure (HP:0008209)	2.09482154
30	Autoimmune hemolytic anemia (HP:0001890)	2.05879015
31	B lymphocytopenia (HP:0010976)	12.4843533
32	Abnormality of B cell number (HP:0010975)	11.2579499
33	Hypoplasia of the thymus (HP:0000778)	10.4153004
34	Panhypogammaglobulinemia (HP:0003139)	10.3741656
35	Constricted visual fields (HP:0001133)	1.97083164
36	Febrile seizures (HP:0002373)	1.95850296
37	Acute lymphatic leukemia (HP:0006721)	1.91631450
38	Elevated erythrocyte sedimentation rate (HP:0003565)	1.89322319
39	Hypoplasia of the pons (HP:0012110)	1.87760340
40	Bony spicule pigmentary retinopathy (HP:0007737)	1.80989577
41	Abolished electroretinogram (ERG) (HP:0000550)	1.78279743
42	Prostate neoplasm (HP:0100787)	1.76030174
43	Neurofibrillary tangles (HP:0002185)	1.74583805
44	Clumsiness (HP:0002312)	1.72168922
45	Impaired smooth pursuit (HP:0007772)	1.70235959
46	Hypoplasia of the iris (HP:0007676)	1.66157453
47	Cellular immunodeficiency (HP:0005374)	1.64885268
48	Congenital stationary night blindness (HP:0007642)	1.64542791
49	Recurrent pneumonia (HP:0006532)	1.63429916
50	Bronchitis (HP:0012387)	1.62723677
51	Asplenia (HP:0001746)	1.61742166
52	Pancreatic fibrosis (HP:0100732)	1.61366986
53	Lymphoma (HP:0002665)	1.59934160
54	Pruritus (HP:0000989)	1.57678532
55	Abnormality of the pons (HP:0007361)	1.55645041
56	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.55061439
57	Attenuation of retinal blood vessels (HP:0007843)	1.52189310
58	Decreased circulating renin level (HP:0003351)	1.50839329
59	Abnormality of the renal collecting system (HP:0004742)	1.50543612
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.49639069
61	Abnormality of midbrain morphology (HP:0002418)	1.47279986
62	Molar tooth sign on MRI (HP:0002419)	1.47279986
63	Abnormality of binocular vision (HP:0011514)	1.46631184
64	Diplopia (HP:0000651)	1.46631184
65	Recurrent lower respiratory tract infections (HP:0002783)	1.45609524
66	Global brain atrophy (HP:0002283)	1.44776383
67	Abnormal biliary tract physiology (HP:0012439)	1.41233489
68	Bile duct proliferation (HP:0001408)	1.41233489
69	Gastrointestinal infarctions (HP:0005244)	1.41024432
70	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.39861957
71	Nephrotic syndrome (HP:0000100)	1.35432169
72	Abnormal rod and cone electroretinograms (HP:0008323)	1.32114097
73	Thrombocytosis (HP:0001894)	1.31550712
74	Autoimmune thrombocytopenia (HP:0001973)	1.30283739
75	True hermaphroditism (HP:0010459)	1.30189866
76	Hypercortisolism (HP:0001578)	1.29040903
77	Abnormality of macrophages (HP:0004311)	1.26965385
78	Cellulitis (HP:0100658)	1.25539981
79	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.25004072
80	Abnormal pancreas size (HP:0012094)	1.24176025
81	Abnormality of ocular smooth pursuit (HP:0000617)	1.23240051
82	Stenosis of the external auditory canal (HP:0000402)	1.23103348
83	Spontaneous hematomas (HP:0007420)	1.22008479
84	Abnormality of the prostate (HP:0008775)	1.21588936
85	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.19742949
86	Genetic anticipation (HP:0003743)	1.18831210
87	Abnormal auditory evoked potentials (HP:0006958)	1.18103505
88	Progressive visual loss (HP:0000529)	1.17320942
89	Acute hepatic failure (HP:0006554)	1.15818223
90	Dysautonomia (HP:0002459)	1.15291691
91	Vacuolated lymphocytes (HP:0001922)	1.14973367
92	Tetany (HP:0001281)	1.14188729
93	Amelogenesis imperfecta (HP:0000705)	1.13768929
94	Chronic diarrhea (HP:0002028)	1.13353400
95	Selective tooth agenesis (HP:0001592)	1.12968354
96	Duplicated collecting system (HP:0000081)	1.12006995
97	Abnormality of endocrine pancreas physiology (HP:0012093)	1.11035986
98	Abnormality of the pancreatic islet cells (HP:0006476)	1.11035986
99	Abnormal ciliary motility (HP:0012262)	1.10282171
100	Chromsome breakage (HP:0040012)	1.09858941

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.90320123
2	CDK19	5.04522268
3	PIK3CG	3.80478015
4	BMPR1B	3.75682099
5	GRK1	3.16969121
6	ADRBK2	2.80320013
7	MET	2.70642947
8	MAP3K13	2.64315591
9	CDK12	2.26371983
10	NLK	2.19014375
11	OXSR1	1.80588136
12	CDK3	1.73200530
13	SCYL2	1.70399575
14	TGFBR1	1.67242604
15	TEC	1.64685387
16	EIF2AK3	1.60288440
17	CDK8	1.59037638
18	TAOK3	1.43010637
19	TESK2	1.39367755
20	STK16	1.37112547
21	FES	1.35637103
22	RPS6KB1	1.27023781
23	ZAK	1.16733341
24	PRKD2	1.11821605
25	MAP2K3	1.06905596
26	TYRO3	1.06711959
27	NTRK3	1.03621792
28	FGFR3	0.99662767
29	MAP3K3	0.97059340
30	WNK1	0.96284596
31	RPS6KA6	0.95395423
32	MAP3K7	0.93198250
33	DYRK1A	0.91317677
34	PIM1	0.90220121
35	TBK1	0.88010067
36	PASK	0.87054292
37	SYK	0.86278327
38	JAK3	0.86102383
39	LYN	0.85703039
40	BRD4	0.85367400
41	TNIK	0.84766068
42	RPS6KL1	0.84333790
43	RPS6KC1	0.84333790
44	MAP3K14	0.77817051
45	LMTK2	0.76340786
46	ITK	0.75712503
47	ERN1	0.74590660
48	MAPKAPK3	0.73193605
49	ACVR1B	0.72089249
50	MAPK13	0.69872310
51	RPS6KA4	0.69361578
52	MAPK4	0.69079302
53	ADRBK1	0.66947063
54	KDR	0.66801583
55	BUB1	0.63937722
56	CSF1R	0.63744454
57	MAPK7	0.62464681
58	LCK	0.62044915
59	MAP3K10	0.61425467
60	BTK	0.60964731
61	CAMK1	0.59040429
62	PRKCE	0.57230473
63	IKBKB	0.57040130
64	CSK	0.56994834
65	LIMK1	0.56825908
66	TGFBR2	0.56452193
67	HCK	0.56265262
68	IRAK1	0.55733689
69	MARK2	0.54152181
70	PDK1	0.53243952
71	STK39	0.51948323
72	RPS6KB2	0.51945407
73	VRK1	0.47544084
74	INSRR	0.46133243
75	AURKA	0.45622524
76	TAOK1	0.45263668
77	STK11	0.44944966
78	MAPK12	0.44568817
79	PAK2	0.44191963
80	EGFR	0.43557493
81	YES1	0.42808622
82	SGK2	0.41576683
83	TXK	0.41552452
84	IGF1R	0.41166321
85	GRK7	0.40405609
86	FLT3	0.39915262
87	PTK2B	0.39515976
88	PDPK1	0.37969252
89	ILK	0.37664019
90	MAP2K2	0.37524306
91	INSR	0.37500495
92	MAP3K4	0.37338410
93	PLK4	0.37313671
94	CDK7	0.36725866
95	KIT	0.34316011
96	MARK3	0.31832619
97	MAPK3	0.31515522
98	CHEK2	0.30746424
99	PRKAA2	0.30743233
100	CHUK	0.30726358

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	5.88082819
2	Non-homologous end-joining_Homo sapiens_hsa03450	5.16092908
3	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.84740591
4	Allograft rejection_Homo sapiens_hsa05330	2.59406911
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.50075682
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.45026079
7	Asthma_Homo sapiens_hsa05310	2.27549739
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.10459888
9	Linoleic acid metabolism_Homo sapiens_hsa00591	1.96158966
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.91454162
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.74824462
12	Phototransduction_Homo sapiens_hsa04744	1.72719426
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.69816499
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.63906695
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.60919002
16	Olfactory transduction_Homo sapiens_hsa04740	1.59637656
17	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.52996549
18	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.51471859
19	Caffeine metabolism_Homo sapiens_hsa00232	1.44758413
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.39885385
21	Homologous recombination_Homo sapiens_hsa03440	1.34818331
22	Butanoate metabolism_Homo sapiens_hsa00650	1.31118390
23	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.30422804
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.30233823
25	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.24462908
26	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.20352611
27	Leishmaniasis_Homo sapiens_hsa05140	1.18232656
28	Ribosome_Homo sapiens_hsa03010	1.14582014
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07767668
30	Retinol metabolism_Homo sapiens_hsa00830	1.03797107
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02554626
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.00272907
33	Serotonergic synapse_Homo sapiens_hsa04726	0.97589972
34	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.97161539
35	FoxO signaling pathway_Homo sapiens_hsa04068	0.91323674
36	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90480137
37	ABC transporters_Homo sapiens_hsa02010	0.90189466
38	Morphine addiction_Homo sapiens_hsa05032	0.89708519
39	Selenocompound metabolism_Homo sapiens_hsa00450	0.89623371
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86171171
41	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.85780029
42	Taste transduction_Homo sapiens_hsa04742	0.82646408
43	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.81979725
44	Platelet activation_Homo sapiens_hsa04611	0.81452009
45	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.79990776
46	Circadian entrainment_Homo sapiens_hsa04713	0.79034658
47	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.75700077
48	Viral myocarditis_Homo sapiens_hsa05416	0.74952871
49	Toxoplasmosis_Homo sapiens_hsa05145	0.73927364
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71378302
51	Mismatch repair_Homo sapiens_hsa03430	0.71019599
52	Herpes simplex infection_Homo sapiens_hsa05168	0.69029819
53	mTOR signaling pathway_Homo sapiens_hsa04150	0.66356857
54	Legionellosis_Homo sapiens_hsa05134	0.66119705
55	Other glycan degradation_Homo sapiens_hsa00511	0.65031446
56	Nicotine addiction_Homo sapiens_hsa05033	0.63936153
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61891539
58	GABAergic synapse_Homo sapiens_hsa04727	0.61814938
59	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60164593
60	Tuberculosis_Homo sapiens_hsa05152	0.59265600
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.58987520
62	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.56592924
63	Bile secretion_Homo sapiens_hsa04976	0.55219377
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52532816
65	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.49282824
66	Salivary secretion_Homo sapiens_hsa04970	0.48712213
67	Fanconi anemia pathway_Homo sapiens_hsa03460	0.48083019
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46516823
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.46228228
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.45766845
71	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.43836233
72	RNA degradation_Homo sapiens_hsa03018	0.43798373
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40382032
74	HTLV-I infection_Homo sapiens_hsa05166	0.39707145
75	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38892080
76	Nitrogen metabolism_Homo sapiens_hsa00910	0.38780733
77	Chemokine signaling pathway_Homo sapiens_hsa04062	0.38310893
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.37559658
79	Ras signaling pathway_Homo sapiens_hsa04014	0.37473716
80	Cholinergic synapse_Homo sapiens_hsa04725	0.37201713
81	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.36810443
82	Influenza A_Homo sapiens_hsa05164	0.35864681
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.35268047
84	Histidine metabolism_Homo sapiens_hsa00340	0.34835983
85	Protein digestion and absorption_Homo sapiens_hsa04974	0.34476345
86	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.33922881
87	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.33347744
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33233990
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.33152853
90	Insulin resistance_Homo sapiens_hsa04931	0.32841919
91	Renin-angiotensin system_Homo sapiens_hsa04614	0.32454096
92	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.31865686
93	Insulin secretion_Homo sapiens_hsa04911	0.31471277
94	Type II diabetes mellitus_Homo sapiens_hsa04930	0.31153576
95	Malaria_Homo sapiens_hsa05144	0.30071899
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.30044566
97	African trypanosomiasis_Homo sapiens_hsa05143	0.29443491
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.29068591
99	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.26835012
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.26444408

TRIM64B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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