TRIM65

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.35486013
2regulation of translational fidelity (GO:0006450)5.20880943
3daunorubicin metabolic process (GO:0044597)4.94734581
4polyketide metabolic process (GO:0030638)4.94734581
5doxorubicin metabolic process (GO:0044598)4.94734581
6DNA strand elongation involved in DNA replication (GO:0006271)4.86540858
7negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.83833276
8DNA replication initiation (GO:0006270)4.83413436
9DNA replication checkpoint (GO:0000076)4.81795575
10positive regulation of gamma-delta T cell activation (GO:0046645)4.74809450
11DNA strand elongation (GO:0022616)4.65558852
12transcription from mitochondrial promoter (GO:0006390)4.48344503
13mitochondrial RNA metabolic process (GO:0000959)4.40017106
14negative regulation of mRNA processing (GO:0050686)4.16749248
15heterochromatin organization (GO:0070828)4.05963975
16folic acid metabolic process (GO:0046655)4.03936132
17telomere maintenance via semi-conservative replication (GO:0032201)3.96696271
18regulation of nuclear cell cycle DNA replication (GO:0033262)3.93533392
19negative regulation of mRNA metabolic process (GO:1903312)3.86212384
20folic acid-containing compound biosynthetic process (GO:0009396)3.86056121
21proline biosynthetic process (GO:0006561)3.84881082
22pseudouridine synthesis (GO:0001522)3.83705125
23tRNA methylation (GO:0030488)3.83053689
24tRNA modification (GO:0006400)3.77327604
25interferon-gamma production (GO:0032609)3.76289757
26viral mRNA export from host cell nucleus (GO:0046784)3.74531485
27chromatin assembly (GO:0031497)3.73839851
28negative regulation of RNA splicing (GO:0033119)3.71482192
29energy homeostasis (GO:0097009)3.70993560
30protein complex localization (GO:0031503)3.70698581
31detection of other organism (GO:0098543)3.70619564
32maturation of SSU-rRNA (GO:0030490)3.70478095
33negative regulation of granulocyte differentiation (GO:0030853)3.70087041
34negative regulation of phagocytosis (GO:0050765)3.64345163
35nucleobase biosynthetic process (GO:0046112)3.63135369
36superoxide anion generation (GO:0042554)3.62589686
37ribosomal small subunit biogenesis (GO:0042274)3.60293389
38regulation of B cell receptor signaling pathway (GO:0050855)3.58042761
39detection of molecule of bacterial origin (GO:0032490)3.56683559
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.55324224
41cellular protein complex localization (GO:0034629)3.53104315
42positive regulation of cellular amide metabolic process (GO:0034250)3.52995154
43DNA duplex unwinding (GO:0032508)3.52539067
44dendritic cell chemotaxis (GO:0002407)3.51255093
45definitive hemopoiesis (GO:0060216)3.47855926
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47273942
47positive regulation of antigen processing and presentation (GO:0002579)3.46966732
48nucleosome disassembly (GO:0006337)3.46105786
49protein-DNA complex disassembly (GO:0032986)3.46105786
50negative regulation of mast cell activation (GO:0033004)3.45621165
51rRNA transcription (GO:0009303)3.41842364
52detection of bacterium (GO:0016045)3.40242378
53DNA geometric change (GO:0032392)3.37975778
54peptidyl-histidine modification (GO:0018202)3.35378777
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.34374670
56response to host immune response (GO:0052572)3.34374670
57telomere maintenance via recombination (GO:0000722)3.34112554
58peptidyl-arginine omega-N-methylation (GO:0035247)3.33641077
59somatic hypermutation of immunoglobulin genes (GO:0016446)3.33565510
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.33565510
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33211057
62positive regulation by organism of defense response of other organism involved in symbiotic interact3.33211057
63modulation by symbiont of host immune response (GO:0052553)3.33211057
64positive regulation by symbiont of host defense response (GO:0052509)3.33211057
65modulation by symbiont of host defense response (GO:0052031)3.33211057
66modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33211057
67regulation of translational elongation (GO:0006448)3.31534556
68maturation of 5.8S rRNA (GO:0000460)3.29631483
69misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.29206092
70regulation of translational termination (GO:0006449)3.24078712
71dendritic cell migration (GO:0036336)3.21240898
72DNA topological change (GO:0006265)3.20838450
73detection of external biotic stimulus (GO:0098581)3.19889621
74IMP biosynthetic process (GO:0006188)3.19858848
75nuclear pore complex assembly (GO:0051292)3.19765660
76response to peptidoglycan (GO:0032494)3.19216367
77regulation of gamma-delta T cell activation (GO:0046643)3.19037923
78meiotic chromosome segregation (GO:0045132)3.17695954
79mitochondrial DNA metabolic process (GO:0032042)3.16906345
80mature B cell differentiation involved in immune response (GO:0002313)3.16844776
81mature B cell differentiation (GO:0002335)3.16087929
82regulation of mitochondrial translation (GO:0070129)3.15650506
83DNA replication-dependent nucleosome organization (GO:0034723)3.15420135
84DNA replication-dependent nucleosome assembly (GO:0006335)3.15420135
85mitotic nuclear envelope disassembly (GO:0007077)3.14654060
86mitotic recombination (GO:0006312)3.14109809
87ribosome biogenesis (GO:0042254)3.11407891
88regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11383384
89UTP biosynthetic process (GO:0006228)3.11378390
90G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.08938551
91translesion synthesis (GO:0019985)3.07956506
92myeloid dendritic cell activation (GO:0001773)3.06737456
93angiogenesis involved in wound healing (GO:0060055)3.06303196
94GMP metabolic process (GO:0046037)3.05188972
95regulation of gene silencing by RNA (GO:0060966)3.01796105
96regulation of posttranscriptional gene silencing (GO:0060147)3.01796105
97regulation of gene silencing by miRNA (GO:0060964)3.01796105
98germinal center formation (GO:0002467)3.01668230
99response to host (GO:0075136)3.00456839
100response to host defenses (GO:0052200)3.00456839
101response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00456839
102DNA replication (GO:0006260)2.99164015
103opioid receptor signaling pathway (GO:0038003)2.98605368
104mitotic sister chromatid segregation (GO:0000070)2.98116795
105purine nucleobase biosynthetic process (GO:0009113)2.96413618
106regulation of dendritic cell antigen processing and presentation (GO:0002604)2.95183890
107positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.95075770
108regulation of antigen processing and presentation (GO:0002577)2.93733421
109nuclear pore organization (GO:0006999)2.92701381
110ribonucleoprotein complex biogenesis (GO:0022613)2.91863926
111regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.91702764
112histone arginine methylation (GO:0034969)2.91570037
113positive regulation of B cell differentiation (GO:0045579)2.91050872
114aminoglycoside antibiotic metabolic process (GO:0030647)2.90522953
115rRNA processing (GO:0006364)2.90433199
116termination of RNA polymerase II transcription (GO:0006369)2.89921363
117pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.89435317
118negative regulation of erythrocyte differentiation (GO:0045647)2.88560179
119base-excision repair (GO:0006284)2.88446698
120megakaryocyte development (GO:0035855)2.88153533
121snRNA metabolic process (GO:0016073)2.87459765
122membrane disassembly (GO:0030397)2.86313025
123nuclear envelope disassembly (GO:0051081)2.86313025
124pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.86112546
125negative regulation of DNA-templated transcription, elongation (GO:0032785)2.85897044
126lymph node development (GO:0048535)2.85226487
127DNA conformation change (GO:0071103)2.81961882
128rRNA metabolic process (GO:0016072)2.81929188
129negative regulation of viral genome replication (GO:0045071)2.81689998
130formation of translation preinitiation complex (GO:0001731)2.81626496
131tetrahydrofolate metabolic process (GO:0046653)2.79792393
132nucleotide-excision repair, DNA gap filling (GO:0006297)2.79318330
133regulation of histone H3-K4 methylation (GO:0051569)2.78400955
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.76882305
135regulation of mast cell activation (GO:0033003)2.76861931
136folic acid-containing compound metabolic process (GO:0006760)2.76801393
137snRNA processing (GO:0016180)2.75431051
138chromatin assembly or disassembly (GO:0006333)2.73959988
139detection of biotic stimulus (GO:0009595)2.73022180
140DNA synthesis involved in DNA repair (GO:0000731)2.72313079
141regulation of B cell differentiation (GO:0045577)2.71798365
142regulation of DNA-dependent DNA replication (GO:0090329)2.71579914
143regulation of mammary gland epithelial cell proliferation (GO:0033599)2.71069395
144pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.70259086
145ncRNA processing (GO:0034470)2.69317274
146positive regulation of interleukin-1 secretion (GO:0050716)2.69022708
147antigen processing and presentation of endogenous antigen (GO:0019883)2.68040915
148regulation of gamma-delta T cell differentiation (GO:0045586)2.67911884
149defense response to protozoan (GO:0042832)2.67091443
150DNA biosynthetic process (GO:0071897)2.67031223
151proline metabolic process (GO:0006560)2.66919855
152RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.66460093
153mRNA splicing, via spliceosome (GO:0000398)2.66460093
154IMP metabolic process (GO:0046040)2.66280005
155DNA strand renaturation (GO:0000733)2.66149436
156cellular extravasation (GO:0045123)2.66041849
157UTP metabolic process (GO:0046051)2.65248267
158negative regulation of histone methylation (GO:0031061)2.64294617
159positive regulation of interleukin-1 beta secretion (GO:0050718)2.63687924
160regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63247067
161cellular response to zinc ion (GO:0071294)2.62846921
162T cell migration (GO:0072678)2.61013426
163positive regulation of interferon-alpha production (GO:0032727)2.60468277
164positive regulation of respiratory burst (GO:0060267)2.59771477
165response to type I interferon (GO:0034340)2.59478004
166immunoglobulin mediated immune response (GO:0016064)2.58693683
167I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.57565240
168regulation of RIG-I signaling pathway (GO:0039535)2.57225757
169production of molecular mediator involved in inflammatory response (GO:0002532)2.57025354
170B cell homeostasis (GO:0001782)2.56115015
171cellular response to type I interferon (GO:0071357)2.56067476
172type I interferon signaling pathway (GO:0060337)2.56067476
173response to muramyl dipeptide (GO:0032495)2.55197556
174regulation of granulocyte differentiation (GO:0030852)2.54702399
175histamine secretion (GO:0001821)2.54495132
176antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.54466882
177antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54466882
178macrophage activation (GO:0042116)2.51858264
179regulation of activation of Janus kinase activity (GO:0010533)2.51329923
180purinergic nucleotide receptor signaling pathway (GO:0035590)2.49818430
181positive regulation of T cell mediated cytotoxicity (GO:0001916)2.49757054
182neutrophil activation (GO:0042119)2.49485580
183ribosomal small subunit assembly (GO:0000028)2.49300980
184histone H3-K36 demethylation (GO:0070544)2.49131696
185neutrophil activation involved in immune response (GO:0002283)2.46974312
186macrophage activation involved in immune response (GO:0002281)2.46435005
187NAD biosynthetic process (GO:0009435)2.46349785
188lymphocyte homeostasis (GO:0002260)2.46206739
189hepatocyte differentiation (GO:0070365)2.44288103
190positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.44061056
191regulation of interleukin-1 beta secretion (GO:0050706)2.42307223
192regulation of interferon-alpha production (GO:0032647)2.41295485
193mesenchymal cell differentiation involved in renal system development (GO:2001012)2.41062878
194mesenchymal cell differentiation involved in kidney development (GO:0072161)2.41062878
195regulation of interleukin-12 biosynthetic process (GO:0045075)2.40867125
196rRNA methylation (GO:0031167)2.40556779
197leukocyte aggregation (GO:0070486)2.39248168
198NIK/NF-kappaB signaling (GO:0038061)2.38999578
199cellular response to exogenous dsRNA (GO:0071360)2.38769586
200B cell receptor signaling pathway (GO:0050853)2.38431760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.08690880
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.23646977
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.13873310
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.86198140
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.77585225
6SCL_19346495_ChIP-Seq_HPC-7_Human3.75271445
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.74134277
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.72862452
9MYC_22102868_ChIP-Seq_BL_Human3.45934474
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.38226736
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.35125878
12VDR_21846776_ChIP-Seq_THP-1_Human2.96805958
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.92321514
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89729139
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88246391
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80973900
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.77978630
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.67444879
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.65520691
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62442068
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55219518
22* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54443975
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52513354
24XRN2_22483619_ChIP-Seq_HELA_Human2.44890396
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39081372
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36463426
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35651979
28RUNX_20019798_ChIP-Seq_JUKART_Human2.33440506
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31898362
30PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25804902
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22332140
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.14700387
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13763415
34ETS1_20019798_ChIP-Seq_JURKAT_Human2.12522411
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07072267
36THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00459476
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.97272510
38GATA1_22025678_ChIP-Seq_K562_Human1.97218507
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96536500
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95277550
41CIITA_25753668_ChIP-Seq_RAJI_Human1.93720112
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.92669985
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91682993
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.91270326
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.91109620
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.90994791
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89998306
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89788519
49GBX2_23144817_ChIP-Seq_PC3_Human1.87884027
50KDM5A_27292631_Chip-Seq_BREAST_Human1.87487390
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85981443
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.85672286
53* GABP_19822575_ChIP-Seq_HepG2_Human1.85644996
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85583207
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84694161
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.83185658
57TTF2_22483619_ChIP-Seq_HELA_Human1.75645484
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.74026111
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72810334
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71277047
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.69590151
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69125703
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68177227
64* DCP1A_22483619_ChIP-Seq_HELA_Human1.66885023
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66545841
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.66448657
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62401820
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62023805
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61465374
70* P68_20966046_ChIP-Seq_HELA_Human1.60452795
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59563362
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58578444
73SPI1_23547873_ChIP-Seq_NB4_Human1.58146325
74FOXP3_21729870_ChIP-Seq_TREG_Human1.56733135
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.53969142
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53669044
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53169574
78LXR_22292898_ChIP-Seq_THP-1_Human1.52697506
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52320782
80* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51784584
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50552066
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.49788370
83MYB_26560356_Chip-Seq_TH2_Human1.48690577
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.48211337
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47615982
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47173696
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.46832767
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46637615
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.45475714
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45418730
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.43049991
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40803084
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37721133
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.37598896
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.37117754
96P53_22387025_ChIP-Seq_ESCs_Mouse1.36569085
97MAF_26560356_Chip-Seq_TH2_Human1.35904664
98FOXP1_21924763_ChIP-Seq_HESCs_Human1.35766525
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35498895
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35444766
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33872508
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32881969
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31455537
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31241767
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.30492293
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28565477
107* ELF1_20517297_ChIP-Seq_JURKAT_Human1.28162653
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27854200
109PU1_27457419_Chip-Seq_LIVER_Mouse1.27508761
110ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27219651
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27124183
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.26707885
113MYB_26560356_Chip-Seq_TH1_Human1.26360466
114P300_18555785_Chip-Seq_ESCs_Mouse1.25096797
115KDM2B_26808549_Chip-Seq_DND41_Human1.24985218
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24189897
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24111892
118VDR_23849224_ChIP-Seq_CD4+_Human1.24029204
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23618947
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.23441764
121ELK3_25401928_ChIP-Seq_HUVEC_Human1.23195667
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22967129
123RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22873185
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22693186
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22669984
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22613701
127PU_27001747_Chip-Seq_BMDM_Mouse1.22186591
128* PHF8_20622854_ChIP-Seq_HELA_Human1.22043379
129OCT4_18555785_Chip-Seq_ESCs_Mouse1.21783078
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21190744
131ZFX_18555785_Chip-Seq_ESCs_Mouse1.20746161
132MAF_26560356_Chip-Seq_TH1_Human1.20408411
133* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19949624
134HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19935914
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19097060
136IRF1_19129219_ChIP-ChIP_H3396_Human1.18334161
137CMYC_18555785_Chip-Seq_ESCs_Mouse1.18013366
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17749240
139KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17723453
140KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16665418
141* NCOR1_26117541_ChIP-Seq_K562_Human1.16537843
142KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16470067
143VDR_24787735_ChIP-Seq_THP-1_Human1.16366966
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16242187
145SA1_27219007_Chip-Seq_ERYTHROID_Human1.15839333
146CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15799486
147RACK7_27058665_Chip-Seq_MCF-7_Human1.14961802
148ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14186948
149RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13404095
150SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13019655
151SOX2_18555785_Chip-Seq_ESCs_Mouse1.12185054
152* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12161146
153ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11541112
154STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11536858
155CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11437567
156MYC_18940864_ChIP-ChIP_HL60_Human1.10971327
157TCF7_22412390_ChIP-Seq_EML_Mouse1.09701361
158RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09587401
159CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09502952
160SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09463360
161GATA1_19941827_ChIP-Seq_MEL_Mouse1.09035513
162OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08924367
163BCL6_27268052_Chip-Seq_Bcells_Human1.08309715
164CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07414701
165UTX_26944678_Chip-Seq_JUKART_Human1.07383770
166* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07311612
167BCOR_27268052_Chip-Seq_Bcells_Human1.06981837
168KLF4_18555785_Chip-Seq_ESCs_Mouse1.06810112
169GABP_17652178_ChIP-ChIP_JURKAT_Human1.06622813
170CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06352676
171GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05726146
172SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05443460
173* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05152865
174CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05087401
175KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05052178
176SPI1_23127762_ChIP-Seq_K562_Human1.04743264
177CTCF_18555785_Chip-Seq_ESCs_Mouse1.04247306
178SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04068071
179* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03018076
180CRX_20693478_ChIP-Seq_RETINA_Mouse1.02005760
181* E2F1_20622854_ChIP-Seq_HELA_Human1.01827349
182E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01657730
183CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00473145
184ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99655054
185GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97520639
186SRF_21415370_ChIP-Seq_HL-1_Mouse0.97432808
187KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96958866
188VDR_24763502_ChIP-Seq_THP-1_Human0.94373976
189GATA3_26560356_Chip-Seq_TH2_Human0.93915517
190HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92802230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.51525654
2MP0003111_abnormal_nucleus_morphology4.35272801
3MP0010094_abnormal_chromosome_stability4.16208229
4MP0001835_abnormal_antigen_presentation3.99703275
5MP0001661_extended_life_span3.65973910
6MP0004957_abnormal_blastocyst_morpholog3.21149154
7MP0003077_abnormal_cell_cycle2.78402493
8MP0002396_abnormal_hematopoietic_system2.75516570
9MP0002132_abnormal_respiratory_system2.73133008
10MP0005671_abnormal_response_to2.64347758
11MP0002148_abnormal_hypersensitivity_rea2.61374680
12MP0009785_altered_susceptibility_to2.60112807
13MP0003724_increased_susceptibility_to2.58890409
14MP0005387_immune_system_phenotype2.48864984
15MP0001790_abnormal_immune_system2.48864984
16MP0001800_abnormal_humoral_immune2.44302905
17MP0008932_abnormal_embryonic_tissue2.43320518
18MP0001188_hyperpigmentation2.34749850
19MP0002419_abnormal_innate_immunity2.31591449
20MP0005076_abnormal_cell_differentiation2.30512022
21MP0005000_abnormal_immune_tolerance2.26213315
22MP0002452_abnormal_antigen_presenting2.25019284
23MP0005464_abnormal_platelet_physiology2.23043211
24MP0005025_abnormal_response_to2.22457777
25MP0004185_abnormal_adipocyte_glucose2.17608096
26MP0005083_abnormal_biliary_tract2.17161389
27MP0002723_abnormal_immune_serum2.09752433
28MP0000685_abnormal_immune_system2.08198800
29MP0003763_abnormal_thymus_physiology2.06584024
30MP0002420_abnormal_adaptive_immunity2.04102206
31MP0001819_abnormal_immune_cell2.03054950
32MP0006292_abnormal_olfactory_placode2.02565554
33MP0004510_myositis1.96574566
34MP0005174_abnormal_tail_pigmentation1.94046579
35MP0005075_abnormal_melanosome_morpholog1.93928211
36MP0006035_abnormal_mitochondrial_morpho1.91063877
37MP0001730_embryonic_growth_arrest1.89579029
38MP0003436_decreased_susceptibility_to1.86637608
39MP0004808_abnormal_hematopoietic_stem1.83857746
40MP0000003_abnormal_adipose_tissue1.81751851
41MP0003786_premature_aging1.81551871
42MP0000350_abnormal_cell_proliferation1.80543773
43MP0002277_abnormal_respiratory_mucosa1.80306362
44MP0009697_abnormal_copulation1.78197084
45MP0004782_abnormal_surfactant_physiolog1.74242996
46MP0000015_abnormal_ear_pigmentation1.73950916
47MP0002398_abnormal_bone_marrow1.72715102
48MP0001873_stomach_inflammation1.72364634
49MP0000716_abnormal_immune_system1.67904663
50MP0004233_abnormal_muscle_weight1.67546803
51MP0010155_abnormal_intestine_physiology1.65072873
52MP0000465_gastrointestinal_hemorrhage1.64940792
53MP0000566_synostosis1.64264652
54MP0005380_embryogenesis_phenotype1.62385459
55MP0001672_abnormal_embryogenesis/_devel1.62385459
56MP0002877_abnormal_melanocyte_morpholog1.56948286
57MP0002405_respiratory_system_inflammati1.54713357
58MP0001853_heart_inflammation1.53932799
59MP0002138_abnormal_hepatobiliary_system1.52638908
60MP0003183_abnormal_peptide_metabolism1.51844634
61MP0001545_abnormal_hematopoietic_system1.51169958
62MP0005397_hematopoietic_system_phenotyp1.51169958
63MP0000313_abnormal_cell_death1.50700307
64MP0000689_abnormal_spleen_morphology1.50469931
65MP0009333_abnormal_splenocyte_physiolog1.49673569
66MP0003984_embryonic_growth_retardation1.48320451
67MP0008058_abnormal_DNA_repair1.46964745
68MP0000537_abnormal_urethra_morphology1.46651368
69MP0009764_decreased_sensitivity_to1.46647460
70MP0001986_abnormal_taste_sensitivity1.45417895
71MP0001845_abnormal_inflammatory_respons1.45073446
72MP0002088_abnormal_embryonic_growth/wei1.43543505
73MP0002080_prenatal_lethality1.40774451
74MP0000490_abnormal_crypts_of1.40231357
75MP0002254_reproductive_system_inflammat1.39884479
76MP0002095_abnormal_skin_pigmentation1.39621834
77MP0003959_abnormal_lean_body1.39155376
78MP0002429_abnormal_blood_cell1.38699238
79MP0002722_abnormal_immune_system1.37047506
80MP0001697_abnormal_embryo_size1.36912769
81MP0002085_abnormal_embryonic_tissue1.34537018
82MP0005310_abnormal_salivary_gland1.33747551
83MP0008961_abnormal_basal_metabolism1.33719331
84MP0009278_abnormal_bone_marrow1.33141425
85MP0006082_CNS_inflammation1.32985333
86MP0003136_yellow_coat_color1.29940784
87MP0004147_increased_porphyrin_level1.28373031
88MP0010307_abnormal_tumor_latency1.27912605
89MP0001346_abnormal_lacrimal_gland1.25168753
90MP0009672_abnormal_birth_weight1.25145531
91MP0002019_abnormal_tumor_incidence1.25116539
92MP0002009_preneoplasia1.24871755
93MP0002084_abnormal_developmental_patter1.19754422
94MP0000358_abnormal_cell_content/1.19667942
95MP0003828_pulmonary_edema1.19234021
96MP0005220_abnormal_exocrine_pancreas1.18663932
97MP0000681_abnormal_thyroid_gland1.17436187
98MP0002928_abnormal_bile_duct1.16973138
99MP0002876_abnormal_thyroid_physiology1.16285049
100MP0003718_maternal_effect1.15693520
101MP0002006_tumorigenesis1.14411229
102MP0003191_abnormal_cellular_cholesterol1.14301332
103MP0008469_abnormal_protein_level1.13159594
104MP0008057_abnormal_DNA_replication1.12921410
105MP0002166_altered_tumor_susceptibility1.12338815
106MP0000703_abnormal_thymus_morphology1.12030627
107MP0008995_early_reproductive_senescence1.11380947
108MP0000678_abnormal_parathyroid_gland1.10861378
109MP0005645_abnormal_hypothalamus_physiol1.08627668
110MP0002086_abnormal_extraembryonic_tissu1.07792982
111MP0005375_adipose_tissue_phenotype1.04960192
112MP0005409_darkened_coat_color1.04663477
113MP0004133_heterotaxia1.04433400
114MP0003119_abnormal_digestive_system1.04201078
115MP0003705_abnormal_hypodermis_morpholog1.03582700
116MP0003868_abnormal_feces_composition1.01819090
117MP0004197_abnormal_fetal_growth/weight/1.01081881
118MP0002234_abnormal_pharynx_morphology1.00535671
119MP0004381_abnormal_hair_follicle0.99641357
120MP0002970_abnormal_white_adipose0.98558045
121MP0003943_abnormal_hepatobiliary_system0.97472741
122MP0003315_abnormal_perineum_morphology0.97232319
123MP0001533_abnormal_skeleton_physiology0.97166456
124MP0008007_abnormal_cellular_replicative0.96729215
125MP0008004_abnormal_stomach_pH0.96596860
126MP0003172_abnormal_lysosome_physiology0.96307424
127MP0006036_abnormal_mitochondrial_physio0.96187180
128MP0003283_abnormal_digestive_organ0.95769429
129MP0005670_abnormal_white_adipose0.94783192
130MP0003937_abnormal_limbs/digits/tail_de0.93300968
131MP0005451_abnormal_body_composition0.92403379
132MP0002111_abnormal_tail_morphology0.91963735
133MP0005167_abnormal_blood-brain_barrier0.91475168
134MP0005647_abnormal_sex_gland0.91283509
135MP0002933_joint_inflammation0.87320626
136MP0010030_abnormal_orbit_morphology0.87041220
137MP0004947_skin_inflammation0.85535529
138MP0002998_abnormal_bone_remodeling0.85298449
139MP0001849_ear_inflammation0.84040953
140MP0003890_abnormal_embryonic-extraembry0.82811625
141MP0001293_anophthalmia0.82369609
142MP0005058_abnormal_lysosome_morphology0.81062355
143MP0000371_diluted_coat_color0.79608116
144MP0000343_altered_response_to0.79429918
145MP0003787_abnormal_imprinting0.78128724
146MP0009763_increased_sensitivity_to0.77657786
147MP0002163_abnormal_gland_morphology0.76055419
148MP0002249_abnormal_larynx_morphology0.74692878
149MP0002102_abnormal_ear_morphology0.74688871
150MP0002938_white_spotting0.74502267
151MP0005171_absent_coat_pigmentation0.73488339
152MP0005646_abnormal_pituitary_gland0.73463569
153MP0003252_abnormal_bile_duct0.72648302
154MP0001186_pigmentation_phenotype0.72455986
155MP0000372_irregular_coat_pigmentation0.72381503
156MP0002210_abnormal_sex_determination0.71028401
157MP0002075_abnormal_coat/hair_pigmentati0.69871838
158MP0003861_abnormal_nervous_system0.68409020
159MP0004019_abnormal_vitamin_homeostasis0.68376530
160MP0002160_abnormal_reproductive_system0.67938290
161MP0005390_skeleton_phenotype0.67641151
162MP0001663_abnormal_digestive_system0.67137602
163MP0003866_abnormal_defecation0.67073166
164MP0001270_distended_abdomen0.65383244
165MP0000049_abnormal_middle_ear0.65290585
166MP0001145_abnormal_male_reproductive0.63971526
167MP0009931_abnormal_skin_appearance0.62603176
168MP0005666_abnormal_adipose_tissue0.62315867
169MP0002092_abnormal_eye_morphology0.60979603
170MP0001919_abnormal_reproductive_system0.57991913
171MP0004858_abnormal_nervous_system0.57374872
172MP0000428_abnormal_craniofacial_morphol0.57335019

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.00450353
2Abnormal number of erythroid precursors (HP:0012131)4.88866520
3Microvesicular hepatic steatosis (HP:0001414)4.63447112
4Abnormality of cells of the erythroid lineage (HP:0012130)4.40364959
5Prolonged bleeding time (HP:0003010)4.12447082
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99367885
7Retrobulbar optic neuritis (HP:0100654)3.83029365
8Optic neuritis (HP:0100653)3.83029365
9Patellar aplasia (HP:0006443)3.82089295
10Progressive muscle weakness (HP:0003323)3.80129719
11Aplasia/Hypoplasia of the patella (HP:0006498)3.75246055
12Chromsome breakage (HP:0040012)3.72114271
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.70972321
14Breast hypoplasia (HP:0003187)3.68703323
15Acute lymphatic leukemia (HP:0006721)3.59652141
16Recurrent abscess formation (HP:0002722)3.55944506
17Myositis (HP:0100614)3.41989043
18Orchitis (HP:0100796)3.35274302
19Agammaglobulinemia (HP:0004432)3.33658466
20Petechiae (HP:0000967)3.18198080
21Recurrent cutaneous fungal infections (HP:0011370)3.16031484
22Chronic mucocutaneous candidiasis (HP:0002728)3.16031484
23Broad distal phalanx of finger (HP:0009836)3.08944366
24Recurrent fungal infections (HP:0002841)3.04279317
25Meningitis (HP:0001287)3.02583475
26Renal cortical cysts (HP:0000803)3.02270267
27Eczematoid dermatitis (HP:0000976)3.00604257
28Joint hemorrhage (HP:0005261)2.97324949
29Menorrhagia (HP:0000132)2.95291211
30Reduced antithrombin III activity (HP:0001976)2.95193842
31Recurrent bacterial skin infections (HP:0005406)2.94947355
32Hypoplasia of the pons (HP:0012110)2.92901184
33Alveolar cell carcinoma (HP:0006519)2.91987181
34Chronic diarrhea (HP:0002028)2.87153523
35Testicular atrophy (HP:0000029)2.84797459
36Squamous cell carcinoma (HP:0002860)2.82354909
37Prostate neoplasm (HP:0100787)2.82191216
38Ragged-red muscle fibers (HP:0003200)2.80177294
39Microretrognathia (HP:0000308)2.76380778
40Panhypogammaglobulinemia (HP:0003139)2.74322581
41Epistaxis (HP:0000421)2.71482647
42Gingival bleeding (HP:0000225)2.70239657
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.70032046
44IgM deficiency (HP:0002850)2.69778987
45Homocystinuria (HP:0002156)2.68761513
46Abnormality of homocysteine metabolism (HP:0010919)2.68761513
47Rectal prolapse (HP:0002035)2.68550303
48Partial agenesis of the corpus callosum (HP:0001338)2.68541649
49Recurrent viral infections (HP:0004429)2.64438245
50Abnormality of the prostate (HP:0008775)2.63643467
51Encephalitis (HP:0002383)2.62414197
52Hyperacusis (HP:0010780)2.61921011
53Impaired platelet aggregation (HP:0003540)2.60363570
54Abnormal platelet function (HP:0011869)2.60363570
55Clubbing of toes (HP:0100760)2.60109669
56Abnormality of the renal collecting system (HP:0004742)2.58211873
57Inflammation of the large intestine (HP:0002037)2.56785902
58Patchy hypopigmentation of hair (HP:0011365)2.54161992
59Mediastinal lymphadenopathy (HP:0100721)2.51423281
60White forelock (HP:0002211)2.51284437
61Vasculitis (HP:0002633)2.50570471
62Recurrent skin infections (HP:0001581)2.50245897
63Reticulocytopenia (HP:0001896)2.49886495
64Abnormality of the pons (HP:0007361)2.48744812
65Neoplasm of the tracheobronchial system (HP:0100552)2.46675640
66Multiple enchondromatosis (HP:0005701)2.46038736
67Absent thumb (HP:0009777)2.44865211
68Progressive microcephaly (HP:0000253)2.43018464
69Pulmonary infiltrates (HP:0002113)2.42132329
70Pseudobulbar signs (HP:0002200)2.41074037
71Keratoconjunctivitis sicca (HP:0001097)2.40883363
72Neoplasm of the adrenal cortex (HP:0100641)2.34574990
73Abnormality of T cell physiology (HP:0011840)2.33936932
74Abnormality of cochlea (HP:0000375)2.33071180
75Meckel diverticulum (HP:0002245)2.32807661
76Abnormality of alanine metabolism (HP:0010916)2.32621602
77Hyperalaninemia (HP:0003348)2.32621602
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32621602
79Truncus arteriosus (HP:0001660)2.32205277
80Gastrointestinal inflammation (HP:0004386)2.31120452
81Type I transferrin isoform profile (HP:0003642)2.28962538
82High pitched voice (HP:0001620)2.28748084
83Short thumb (HP:0009778)2.28478423
84Keratoconjunctivitis (HP:0001096)2.27800236
85Abnormality of the ileum (HP:0001549)2.27649634
86Dysmetric saccades (HP:0000641)2.26378001
87Type 2 muscle fiber atrophy (HP:0003554)2.26321829
88Recurrent gram-negative bacterial infections (HP:0005420)2.25858355
89Abnormality of the carotid arteries (HP:0005344)2.24712913
90Bilateral microphthalmos (HP:0007633)2.23417411
91Elevated erythrocyte sedimentation rate (HP:0003565)2.22248752
92Absent radius (HP:0003974)2.22118376
93Periodontitis (HP:0000704)2.21243795
94Recurrent pneumonia (HP:0006532)2.20651763
95Pendular nystagmus (HP:0012043)2.18117402
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17824944
97Aplasia involving forearm bones (HP:0009822)2.17782440
98Absent forearm bone (HP:0003953)2.17782440
99Protruding tongue (HP:0010808)2.16536010
100Abnormal number of incisors (HP:0011064)2.15588576
101Slender long bone (HP:0003100)2.14579859
102Myelodysplasia (HP:0002863)2.14304316
103Chronic otitis media (HP:0000389)2.14041696
104Unilateral renal agenesis (HP:0000122)2.12634673
105Duplicated collecting system (HP:0000081)2.10826818
106Systemic lupus erythematosus (HP:0002725)2.10544161
107Thrombocytosis (HP:0001894)2.10244486
108Thyroiditis (HP:0100646)2.09624042
109Increased cerebral lipofuscin (HP:0011813)2.09506435
110Abnormality of the fingertips (HP:0001211)2.08577980
111Arterial thrombosis (HP:0004420)2.08400598
112Obstructive lung disease (HP:0006536)2.07945898
113Chronic obstructive pulmonary disease (HP:0006510)2.07945898
114Colitis (HP:0002583)2.07641340
115Lymphopenia (HP:0001888)2.07361721
116Cheilitis (HP:0100825)2.05301210
117Spontaneous hematomas (HP:0007420)2.05098804
118Gingivitis (HP:0000230)2.04620196
119Abnormality of T cells (HP:0002843)2.03042489
120Recurrent lower respiratory tract infections (HP:0002783)2.02477670
121Cleft eyelid (HP:0000625)2.02050087
122Hemoptysis (HP:0002105)1.99727415
123External ophthalmoplegia (HP:0000544)1.98994620
124Ulnar bowing (HP:0003031)1.98328486
125Basal cell carcinoma (HP:0002671)1.97503045
126Pallor (HP:0000980)1.97038442
127Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94455047
128Purpura (HP:0000979)1.94015590
129Abnormality of cells of the lymphoid lineage (HP:0012140)1.92416877
130Spinal cord lesions (HP:0100561)1.91105311
131Syringomyelia (HP:0003396)1.91105311
132Morphological abnormality of the inner ear (HP:0011390)1.91082748
133Septate vagina (HP:0001153)1.90563932
134Abnormality of the preputium (HP:0100587)1.89080805
135Premature ovarian failure (HP:0008209)1.89074158
136Hypertensive crisis (HP:0100735)1.88826829
137Ectopic kidney (HP:0000086)1.88477922
138Albinism (HP:0001022)1.87828352
139Clumsiness (HP:0002312)1.86445210
140Congenital sensorineural hearing impairment (HP:0008527)1.85711914
141Chronic hepatic failure (HP:0100626)1.85417748
142Abnormality of the renal cortex (HP:0011035)1.84883167
143Aplastic anemia (HP:0001915)1.84529055
144Elfin facies (HP:0004428)1.84322158
145Abnormality of DNA repair (HP:0003254)1.84314755
146Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84184065
147Abnormal protein N-linked glycosylation (HP:0012347)1.84184065
148Abnormal protein glycosylation (HP:0012346)1.84184065
149Abnormal glycosylation (HP:0012345)1.84184065
150Neonatal hypoglycemia (HP:0001998)1.83157799
151Abnormality of macrophages (HP:0004311)1.81939051
152Pancytopenia (HP:0001876)1.81670453
153Concave nail (HP:0001598)1.81648009
154Autoimmune thrombocytopenia (HP:0001973)1.81307838
155Progressive inability to walk (HP:0002505)1.81103832
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.81072584
157Abnormality of chromosome stability (HP:0003220)1.80886661
1583-Methylglutaconic aciduria (HP:0003535)1.80355947
159Lip pit (HP:0100267)1.79833353
160Neutropenia (HP:0001875)1.79766879
161Osteomyelitis (HP:0002754)1.79038349
162Keratitis (HP:0000491)1.79017413
163Granulocytopenia (HP:0001913)1.78910867
164Leukopenia (HP:0001882)1.78754884
165Rib fusion (HP:0000902)1.78667034
166Abnormal platelet volume (HP:0011876)1.78665577
167Abnormal hair whorl (HP:0010721)1.78394515
168Cerebellar dysplasia (HP:0007033)1.77753530
169Increased serum lactate (HP:0002151)1.77613347
170Lissencephaly (HP:0001339)1.77253268
171Colon cancer (HP:0003003)1.75571739
172Bone marrow hypocellularity (HP:0005528)1.73644267
173Atresia of the external auditory canal (HP:0000413)1.73105436
174Seborrheic dermatitis (HP:0001051)1.71621338
175Cafe-au-lait spot (HP:0000957)1.70581458
176Abnormality of the columella (HP:0009929)1.69903112
177Abnormality of reticulocytes (HP:0004312)1.69190117
178Insomnia (HP:0100785)1.68631095
179Intestinal fistula (HP:0100819)1.67896822
180Abnormality of chromosome segregation (HP:0002916)1.67464560
181Poikiloderma (HP:0001029)1.67078345
182Neoplasm of head and neck (HP:0012288)1.66965262
183Esophageal neoplasm (HP:0100751)1.66965262
184Type II lissencephaly (HP:0007260)1.66663937
185Urethral obstruction (HP:0000796)1.66254182
186Abnormality of subcutaneous fat tissue (HP:0001001)1.65166900
187Nonimmune hydrops fetalis (HP:0001790)1.62744946
188Progressive external ophthalmoplegia (HP:0000590)1.62102399
189Horseshoe kidney (HP:0000085)1.61545680
190Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60561724
191Optic nerve coloboma (HP:0000588)1.60161358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.73654328
2TRIB33.97950759
3SMG13.80507069
4BRD43.67158240
5MAP3K143.56949232
6ICK3.28788503
7TXK3.08759758
8NEK22.93766910
9ZAK2.70516116
10CDC72.69198928
11IRAK42.59544578
12SIK32.48025356
13IRAK32.47069657
14BUB12.42112940
15TLK12.20446971
16VRK22.14560927
17MAP4K12.06198764
18GRK12.05353369
19MKNK21.97034938
20TIE11.89884178
21CASK1.86536910
22CHEK21.82691156
23MAP3K101.80129648
24TEC1.75291046
25IKBKB1.69056772
26CDK41.68463352
27PRPF4B1.67792242
28CAMK1D1.64869103
29IKBKE1.64835046
30KIT1.58881895
31JAK31.57484130
32BTK1.57035181
33YES11.56338659
34SGK21.51738253
35RPS6KB21.49465697
36TYK21.47217150
37TAOK31.46713185
38CDK71.45953409
39TGFBR21.43360565
40MAP2K21.40703875
41MAPK111.39982468
42NEK91.39447224
43EIF2AK21.38634978
44NLK1.33650031
45TSSK61.33204480
46NEK11.31904176
47PIK3CG1.30774510
48TAF11.30212013
49JAK11.29680406
50FRK1.28836071
51SYK1.28687782
52BLK1.26778217
53NME21.26738200
54MKNK11.26559807
55ADRBK21.25043208
56ERN11.24943054
57KDR1.24837551
58CHUK1.23428903
59TNK21.21561095
60INSRR1.20874576
61WNK41.20384930
62TTK1.18001591
63MAP3K131.14499153
64PIM11.12857591
65MUSK1.10414227
66CCNB11.09724576
67AKT31.08904223
68PKN21.07809094
69CSF1R1.05776199
70CDK81.05157528
71SGK31.04198693
72CAMK1G1.02772379
73BMPR21.02265717
74NUAK11.02066296
75STK161.02064542
76STK241.01224137
77PIK3CA1.00261145
78LYN0.97173394
79TNIK0.95368147
80NME10.94721921
81MAPKAPK50.94408660
82CHEK10.91347634
83ZAP700.91189183
84MAPK70.90045270
85TBK10.89607498
86PRKCI0.88033975
87HCK0.85399228
88TRPM70.85258480
89MELK0.83818994
90ALK0.83002308
91MAP3K70.82461543
92AURKA0.81249346
93MAP2K30.79785699
94MARK30.77319432
95IRAK10.76770541
96MTOR0.76540126
97PLK10.76428796
98WEE10.76157264
99LCK0.75721007
100EPHA30.73554787
101TESK20.73391384
102GRK70.73381395
103VRK10.72383182
104PASK0.72302606
105CDK20.72007946
106BMPR1B0.71121055
107TAOK20.70586399
108CDK90.70501114
109CLK10.69672130
110STK40.69603198
111MAP3K80.69393015
112CDK10.68537805
113PNCK0.68524737
114PINK10.67154018
115TYRO30.66887651
116SRPK10.65078211
117IRAK20.63646517
118PLK40.63189928
119CDK120.61711110
120GRK60.61285855
121MAP3K110.61263146
122AURKB0.61244167
123TGFBR10.61145406
124ATR0.60997315
125RIPK40.60572237
126FGFR30.58705321
127ITK0.58551640
128CDK30.58505650
129NEK60.58013761
130SGK4940.56447524
131SGK2230.56447524
132RPS6KA50.53680249
133FLT30.52480352
134MYLK0.52305847
135ERBB30.51497206
136ATM0.50811964
137HIPK20.50398470
138RPS6KA40.49811460
139RPS6KC10.49674502
140RPS6KL10.49674502
141STK38L0.48615393
142SIK20.46986186
143MAPK150.45323427
144CSK0.44565116
145PRKCQ0.44485219
146CSNK1G30.44277073
147RPS6KB10.44212324
148PRKD20.44019986
149CAMKK20.42320966
150RPS6KA10.41770951
151PRKAA20.41576413
152RPS6KA60.40810151
153PIM20.40787934
154CDK60.40301418
155MAPK120.39533069
156PRKAA10.39300131
157MAP3K30.38861515
158LRRK20.38015706
159PTK60.37644680
160SIK10.37528844
161PDPK10.36925263
162MATK0.36652902
163MAPK30.35599912
164SCYL20.35233966
165AKT10.35099129
166CAMKK10.33595815
167PBK0.33403870
168BCKDK0.31821535
169MAPK80.30138568
170MAPKAPK30.30047798
171CSNK1A1L0.28552661
172RAF10.27431801

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.26928070
2Caffeine metabolism_Homo sapiens_hsa002322.94303668
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.84625816
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83899403
5Primary immunodeficiency_Homo sapiens_hsa053402.75922457
6Spliceosome_Homo sapiens_hsa030402.66723698
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.63915781
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.61174931
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.47988485
10Sulfur relay system_Homo sapiens_hsa041222.46518406
11Hematopoietic cell lineage_Homo sapiens_hsa046402.37860331
12Measles_Homo sapiens_hsa051622.31988181
13Staphylococcus aureus infection_Homo sapiens_hsa051502.25900923
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.24976629
15Leishmaniasis_Homo sapiens_hsa051402.23167991
16Nucleotide excision repair_Homo sapiens_hsa034202.21692906
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.20729062
18Cell cycle_Homo sapiens_hsa041102.15498791
19RNA polymerase_Homo sapiens_hsa030202.12162871
20Selenocompound metabolism_Homo sapiens_hsa004502.04111805
21Other glycan degradation_Homo sapiens_hsa005112.03973670
22RNA transport_Homo sapiens_hsa030132.02006758
23Ribosome_Homo sapiens_hsa030101.98754551
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.87291404
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86644204
26Fanconi anemia pathway_Homo sapiens_hsa034601.82290092
27Allograft rejection_Homo sapiens_hsa053301.77083752
28Graft-versus-host disease_Homo sapiens_hsa053321.76309971
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70984513
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.68175005
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63216522
32Herpes simplex infection_Homo sapiens_hsa051681.62378026
33Osteoclast differentiation_Homo sapiens_hsa043801.60181039
34Homologous recombination_Homo sapiens_hsa034401.57823600
35Base excision repair_Homo sapiens_hsa034101.55044312
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54390543
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49947424
38B cell receptor signaling pathway_Homo sapiens_hsa046621.48901138
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.47816016
40Autoimmune thyroid disease_Homo sapiens_hsa053201.46490718
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.41923470
42Biosynthesis of amino acids_Homo sapiens_hsa012301.39514085
43Legionellosis_Homo sapiens_hsa051341.34244776
44Influenza A_Homo sapiens_hsa051641.33850159
45Non-homologous end-joining_Homo sapiens_hsa034501.32310947
46One carbon pool by folate_Homo sapiens_hsa006701.30785858
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29645394
48ABC transporters_Homo sapiens_hsa020101.27904621
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26863984
50TNF signaling pathway_Homo sapiens_hsa046681.25778212
51mRNA surveillance pathway_Homo sapiens_hsa030151.23116411
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23024174
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.22328011
54Vitamin B6 metabolism_Homo sapiens_hsa007501.17212085
55Pertussis_Homo sapiens_hsa051331.15862201
56Malaria_Homo sapiens_hsa051441.13550239
57Bladder cancer_Homo sapiens_hsa052191.10603108
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04072530
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03454995
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.02732097
61Non-small cell lung cancer_Homo sapiens_hsa052231.01559863
62Acute myeloid leukemia_Homo sapiens_hsa052211.00136074
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99501102
64Systemic lupus erythematosus_Homo sapiens_hsa053220.99456394
65Viral carcinogenesis_Homo sapiens_hsa052030.97340698
66Antigen processing and presentation_Homo sapiens_hsa046120.97289255
67Tuberculosis_Homo sapiens_hsa051520.95915729
68Complement and coagulation cascades_Homo sapiens_hsa046100.94554894
69Arachidonic acid metabolism_Homo sapiens_hsa005900.93595940
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.93287477
71Toxoplasmosis_Homo sapiens_hsa051450.91997457
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.91779941
73Hepatitis B_Homo sapiens_hsa051610.88991744
74Apoptosis_Homo sapiens_hsa042100.86760928
75Chemokine signaling pathway_Homo sapiens_hsa040620.85652172
76Basal cell carcinoma_Homo sapiens_hsa052170.84794748
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84349221
78T cell receptor signaling pathway_Homo sapiens_hsa046600.84013513
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83940046
80Asthma_Homo sapiens_hsa053100.83516539
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83372793
82Vitamin digestion and absorption_Homo sapiens_hsa049770.80919614
83Rheumatoid arthritis_Homo sapiens_hsa053230.80528444
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79300949
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79200396
86Fructose and mannose metabolism_Homo sapiens_hsa000510.79092793
87Hepatitis C_Homo sapiens_hsa051600.78886564
88Colorectal cancer_Homo sapiens_hsa052100.78846443
89Pentose phosphate pathway_Homo sapiens_hsa000300.77913839
90Retinol metabolism_Homo sapiens_hsa008300.75210867
91Sphingolipid metabolism_Homo sapiens_hsa006000.73368138
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73323224
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69995428
94African trypanosomiasis_Homo sapiens_hsa051430.68518431
95Alcoholism_Homo sapiens_hsa050340.67285938
96Pyruvate metabolism_Homo sapiens_hsa006200.66850588
97Basal transcription factors_Homo sapiens_hsa030220.66721557
98mTOR signaling pathway_Homo sapiens_hsa041500.64967332
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63211170
100Chemical carcinogenesis_Homo sapiens_hsa052040.62969256
101VEGF signaling pathway_Homo sapiens_hsa043700.62655357
102Pancreatic cancer_Homo sapiens_hsa052120.62517668
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62196263
104Carbon metabolism_Homo sapiens_hsa012000.61210494
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59917102
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59622037
107Mismatch repair_Homo sapiens_hsa034300.59302517
108Platelet activation_Homo sapiens_hsa046110.58994913
109beta-Alanine metabolism_Homo sapiens_hsa004100.58942507
110MicroRNAs in cancer_Homo sapiens_hsa052060.58617942
111Melanoma_Homo sapiens_hsa052180.57677929
112Epstein-Barr virus infection_Homo sapiens_hsa051690.56461675
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55840150
114Pyrimidine metabolism_Homo sapiens_hsa002400.54903686
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54810243
116DNA replication_Homo sapiens_hsa030300.54308783
117p53 signaling pathway_Homo sapiens_hsa041150.52268304
118Histidine metabolism_Homo sapiens_hsa003400.51952662
119Thyroid cancer_Homo sapiens_hsa052160.50168667
120Galactose metabolism_Homo sapiens_hsa000520.48894021
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48323067
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.47702411
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47019453
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46830199
125Starch and sucrose metabolism_Homo sapiens_hsa005000.46451970
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.46415878
127Inositol phosphate metabolism_Homo sapiens_hsa005620.45737873
128HTLV-I infection_Homo sapiens_hsa051660.45028601
129Lysine degradation_Homo sapiens_hsa003100.44302684
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43591442
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43499703
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42843224
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.42816524
134Notch signaling pathway_Homo sapiens_hsa043300.42135951
135Hedgehog signaling pathway_Homo sapiens_hsa043400.41290676
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41078119
137Phototransduction_Homo sapiens_hsa047440.41000954
138Salmonella infection_Homo sapiens_hsa051320.40768952
139Type I diabetes mellitus_Homo sapiens_hsa049400.40601699
140Prolactin signaling pathway_Homo sapiens_hsa049170.40521979
141Ether lipid metabolism_Homo sapiens_hsa005650.40302668
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39451875
143Nitrogen metabolism_Homo sapiens_hsa009100.39356059
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.39241072
145Purine metabolism_Homo sapiens_hsa002300.38725357
146Small cell lung cancer_Homo sapiens_hsa052220.36591969
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36185279
148RNA degradation_Homo sapiens_hsa030180.35659905
149Metabolic pathways_Homo sapiens_hsa011000.35633213
150Chronic myeloid leukemia_Homo sapiens_hsa052200.35414764
151Lysosome_Homo sapiens_hsa041420.34433425
152AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34248207
153N-Glycan biosynthesis_Homo sapiens_hsa005100.34240966
154AMPK signaling pathway_Homo sapiens_hsa041520.34118114
155Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33177296
156Endometrial cancer_Homo sapiens_hsa052130.32958872
157Peroxisome_Homo sapiens_hsa041460.32296858
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32283759
159Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31610091
160Prostate cancer_Homo sapiens_hsa052150.30650813
161Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30098133
162Phagosome_Homo sapiens_hsa041450.30022471
163Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27127170
164Hippo signaling pathway_Homo sapiens_hsa043900.25165481

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