TRIM67

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)9.30123570
2response to pheromone (GO:0019236)7.62770922
3nucleobase catabolic process (GO:0046113)7.27564618
4cell migration in hindbrain (GO:0021535)6.21622709
5neuron cell-cell adhesion (GO:0007158)5.80823132
6layer formation in cerebral cortex (GO:0021819)5.79421100
7vocalization behavior (GO:0071625)5.47956908
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.36225259
9dendritic spine morphogenesis (GO:0060997)5.23440679
10central nervous system projection neuron axonogenesis (GO:0021952)5.21486424
11protein localization to synapse (GO:0035418)4.96550617
12neuron recognition (GO:0008038)4.93072806
13dendrite morphogenesis (GO:0048813)4.91001592
14axonal fasciculation (GO:0007413)4.76103337
15negative regulation of microtubule polymerization (GO:0031115)4.75502433
16postsynaptic membrane organization (GO:0001941)4.45368732
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44344269
18regulation of glutamate receptor signaling pathway (GO:1900449)4.44331803
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.35901524
20regulation of short-term neuronal synaptic plasticity (GO:0048172)4.33483841
21axon extension (GO:0048675)4.28824702
22locomotory exploration behavior (GO:0035641)4.23989128
23establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.16428169
24mitochondrion transport along microtubule (GO:0047497)4.16428169
25establishment of mitochondrion localization (GO:0051654)4.10164992
26central nervous system neuron axonogenesis (GO:0021955)4.09007490
27regulation of synapse structural plasticity (GO:0051823)4.05749412
28exploration behavior (GO:0035640)4.02519446
29synaptic vesicle maturation (GO:0016188)4.00070698
30positive regulation of synapse maturation (GO:0090129)3.92549157
31synaptic vesicle exocytosis (GO:0016079)3.86137833
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.78984574
33suckling behavior (GO:0001967)3.78411971
34proline transport (GO:0015824)3.77875388
35regulation of synaptic vesicle exocytosis (GO:2000300)3.77485624
36cerebral cortex radially oriented cell migration (GO:0021799)3.73570565
37startle response (GO:0001964)3.69127885
38neuron projection extension (GO:1990138)3.67487920
39positive regulation of synapse assembly (GO:0051965)3.65581425
40auditory behavior (GO:0031223)3.65005160
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64269760
42positive regulation of filopodium assembly (GO:0051491)3.63793466
43cerebellum development (GO:0021549)3.52772041
44glutamate receptor signaling pathway (GO:0007215)3.47389993
45synapse assembly (GO:0007416)3.46642178
46regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.42808476
47hippocampus development (GO:0021766)3.40999873
48regulation of synapse maturation (GO:0090128)3.40345589
49regulation of cAMP-dependent protein kinase activity (GO:2000479)3.39907926
50regulation of microtubule polymerization (GO:0031113)3.39101680
51synaptic transmission, glutamatergic (GO:0035249)3.38292873
52clathrin coat assembly (GO:0048268)3.36940779
53cerebellar granule cell differentiation (GO:0021707)3.36147791
54presynaptic membrane assembly (GO:0097105)3.34637266
55response to auditory stimulus (GO:0010996)3.33819604
56regulation of axon extension (GO:0030516)3.31677526
57neurotransmitter-gated ion channel clustering (GO:0072578)3.31653019
58positive regulation of axon extension (GO:0045773)3.31312505
59neuron migration (GO:0001764)3.30950068
60regulation of axon extension involved in axon guidance (GO:0048841)3.30128401
61regulation of axon guidance (GO:1902667)3.29631499
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.21967475
63glutamate secretion (GO:0014047)3.21890773
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.19276382
65positive regulation of dendritic spine development (GO:0060999)3.17666924
66positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.17383670
67presynaptic membrane organization (GO:0097090)3.17274627
68dendritic spine organization (GO:0097061)3.15940474
69dopamine receptor signaling pathway (GO:0007212)3.15940447
70regulation of synaptic vesicle transport (GO:1902803)3.13475383
71membrane assembly (GO:0071709)3.13448998
72dendrite development (GO:0016358)3.11732140
73regulation of respiratory system process (GO:0044065)3.11661225
74neurotransmitter secretion (GO:0007269)3.09967060
75regulation of synapse assembly (GO:0051963)3.09262901
76positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07177344
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06718351
78synaptic vesicle endocytosis (GO:0048488)3.03505995
79neuronal action potential propagation (GO:0019227)3.03100533
80regulation of synapse organization (GO:0050807)3.01182369
81regulation of extent of cell growth (GO:0061387)3.00298400
82innervation (GO:0060384)3.00150809
83regulation of filopodium assembly (GO:0051489)2.99850692
84transmission of nerve impulse (GO:0019226)2.99829533
85adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.98518839
86neuron-neuron synaptic transmission (GO:0007270)2.98061690
87regulation of dendritic spine morphogenesis (GO:0061001)2.98059265
88mating behavior (GO:0007617)2.97124921
89homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.97025392
90membrane depolarization during action potential (GO:0086010)2.96138382
91cartilage morphogenesis (GO:0060536)2.95823613
92neuron projection morphogenesis (GO:0048812)2.94485927
93synapse organization (GO:0050808)2.94458824
94cerebellar Purkinje cell differentiation (GO:0021702)2.94268854
95membrane hyperpolarization (GO:0060081)2.93907797
96regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93629446
97gamma-aminobutyric acid transport (GO:0015812)2.93043475
98neuronal ion channel clustering (GO:0045161)2.92575884
99axonogenesis (GO:0007409)2.92398843
100neuromuscular process controlling balance (GO:0050885)2.92231468
101regulation of synaptic transmission, glutamatergic (GO:0051966)2.89864509
102retinal ganglion cell axon guidance (GO:0031290)2.89515892
103positive regulation of membrane potential (GO:0045838)2.89394436
104positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89179999
105membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88892666
106heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.88504232
107spinal cord development (GO:0021510)2.87882866
108generation of neurons (GO:0048699)2.86941961
109cerebellar Purkinje cell layer development (GO:0021680)2.85671174
110organelle transport along microtubule (GO:0072384)2.85522922
111regulation of neuronal synaptic plasticity (GO:0048168)2.85382456
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85133311
113negative regulation of axon extension (GO:0030517)2.84350985
114regulation of long-term neuronal synaptic plasticity (GO:0048169)2.84037483
115axon cargo transport (GO:0008088)2.83400457
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83304864
117regulation of postsynaptic membrane potential (GO:0060078)2.83057022
118mechanosensory behavior (GO:0007638)2.82971771
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81736986
120neuromuscular synaptic transmission (GO:0007274)2.80883643
121cell differentiation in hindbrain (GO:0021533)2.79967339
122establishment of nucleus localization (GO:0040023)2.77647628
123adult walking behavior (GO:0007628)2.76322709
124membrane depolarization (GO:0051899)2.76304638
125positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.75332839
126regulation of respiratory gaseous exchange (GO:0043576)2.74611640
127regulation of vesicle fusion (GO:0031338)2.72472762
128neuromuscular process (GO:0050905)2.71853101
129negative regulation of axonogenesis (GO:0050771)2.70655794
130long-term memory (GO:0007616)2.70217809
131sympathetic nervous system development (GO:0048485)2.69220010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.37757355
2GBX2_23144817_ChIP-Seq_PC3_Human3.50829610
3EZH2_27304074_Chip-Seq_ESCs_Mouse3.14953303
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14750194
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96380281
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84105051
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.79110529
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74322397
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70749936
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70749936
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63130355
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.60901632
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55187188
14* EZH2_27294783_Chip-Seq_ESCs_Mouse2.51690032
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41170496
16* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39180649
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.37843360
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.37744577
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35121862
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.33818542
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30374910
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22928499
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.08415536
24AR_21572438_ChIP-Seq_LNCaP_Human2.05724943
25DROSHA_22980978_ChIP-Seq_HELA_Human2.05701129
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.04012215
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93652088
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90329997
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88487922
30ZNF274_21170338_ChIP-Seq_K562_Hela1.86099589
31IGF1R_20145208_ChIP-Seq_DFB_Human1.84815861
32* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79400646
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76605502
34RNF2_27304074_Chip-Seq_NSC_Mouse1.71749807
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70605824
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64299591
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60766751
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59485148
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.58805674
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.56528695
41* RING1B_27294783_Chip-Seq_NPCs_Mouse1.55121880
42TAF15_26573619_Chip-Seq_HEK293_Human1.54409603
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45976570
44P300_19829295_ChIP-Seq_ESCs_Human1.42032266
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.40572355
46SMAD4_21799915_ChIP-Seq_A2780_Human1.37186752
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34474172
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34464908
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33550508
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32707960
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31691398
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31691398
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28887981
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.28161081
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27307234
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.26834099
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22301219
58* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21904690
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20998551
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19869784
61RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18820471
62AR_25329375_ChIP-Seq_VCAP_Human1.15744616
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15282406
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14682491
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14140629
66AR_19668381_ChIP-Seq_PC3_Human1.14096033
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12418671
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.11647606
69YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10938917
70LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10851556
71FUS_26573619_Chip-Seq_HEK293_Human1.10494100
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09708281
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08886475
74AHR_22903824_ChIP-Seq_MCF-7_Human1.08418415
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08108549
76STAT3_23295773_ChIP-Seq_U87_Human1.06898291
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.06674861
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06588635
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06249172
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06201031
81RUNX2_22187159_ChIP-Seq_PCA_Human1.04749037
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.04623261
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.04288954
84* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04150551
85KDM2B_26808549_Chip-Seq_K562_Human1.04036051
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02994789
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01785777
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01308997
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00973196
90CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99852246
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98574715
92WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97893400
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97888234
94* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97233647
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96569992
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96111442
97VDR_22108803_ChIP-Seq_LS180_Human0.95153852
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.94836113
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94685460
100ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94495165
101SOX9_26525672_Chip-Seq_HEART_Mouse0.94489464
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94113482
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94032060
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93852810
105TCF4_23295773_ChIP-Seq_U87_Human0.93182313
106PRDM14_20953172_ChIP-Seq_ESCs_Human0.92775727
107CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91732415
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91700276
109JUN_21703547_ChIP-Seq_K562_Human0.90860505
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90678302
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90389412
112ER_23166858_ChIP-Seq_MCF-7_Human0.90300303
113KDM2B_26808549_Chip-Seq_REH_Human0.88720818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.68519668
2MP0005423_abnormal_somatic_nervous3.98659205
3MP0004270_analgesia3.65400770
4MP0000778_abnormal_nervous_system3.56487963
5MP0003880_abnormal_central_pattern3.36125788
6MP0003635_abnormal_synaptic_transmissio3.24120910
7MP0006276_abnormal_autonomic_nervous3.07519839
8MP0002735_abnormal_chemical_nociception3.00778418
9MP0002063_abnormal_learning/memory/cond2.87986478
10MP0002734_abnormal_mechanical_nocicepti2.82289828
11MP0002184_abnormal_innervation2.76142741
12MP0001968_abnormal_touch/_nociception2.62223285
13MP0005645_abnormal_hypothalamus_physiol2.60470153
14MP0002733_abnormal_thermal_nociception2.42562221
15MP0002822_catalepsy2.32792834
16MP0002572_abnormal_emotion/affect_behav2.26294840
17MP0009745_abnormal_behavioral_response2.23149452
18MP0001486_abnormal_startle_reflex2.14114656
19MP0000569_abnormal_digit_pigmentation2.12824019
20MP0009046_muscle_twitch2.09914637
21MP0002557_abnormal_social/conspecific_i2.04716030
22MP0002102_abnormal_ear_morphology2.01447040
23MP0004858_abnormal_nervous_system2.01291224
24MP0001970_abnormal_pain_threshold2.00561368
25MP0002736_abnormal_nociception_after1.97687169
26MP0001440_abnormal_grooming_behavior1.97331165
27MP0000579_abnormal_nail_morphology1.94765523
28MP0002064_seizures1.93582609
29MP0004811_abnormal_neuron_physiology1.93413447
30MP0001984_abnormal_olfaction1.87422348
31MP0000955_abnormal_spinal_cord1.83781291
32MP0000537_abnormal_urethra_morphology1.80419063
33MP0002067_abnormal_sensory_capabilities1.78647392
34MP0002882_abnormal_neuron_morphology1.63182901
35MP0002272_abnormal_nervous_system1.63068055
36MP0003122_maternal_imprinting1.59174372
37MP0005386_behavior/neurological_phenoty1.58787799
38MP0004924_abnormal_behavior1.58787799
39MP0004742_abnormal_vestibular_system1.58191501
40MP0002638_abnormal_pupillary_reflex1.48753695
41MP0000631_abnormal_neuroendocrine_gland1.45753541
42MP0009780_abnormal_chondrocyte_physiolo1.45693040
43MP0002152_abnormal_brain_morphology1.45236374
44MP0010386_abnormal_urinary_bladder1.41434382
45MP0003329_amyloid_beta_deposits1.40969422
46MP0004885_abnormal_endolymph1.38889491
47MP0001188_hyperpigmentation1.35849540
48MP0001502_abnormal_circadian_rhythm1.34625148
49MP0006292_abnormal_olfactory_placode1.33691643
50MP0002066_abnormal_motor_capabilities/c1.30426224
51MP0003861_abnormal_nervous_system1.29984361
52MP0008569_lethality_at_weaning1.23328403
53MP0002752_abnormal_somatic_nervous1.22550790
54MP0005499_abnormal_olfactory_system1.21901779
55MP0005394_taste/olfaction_phenotype1.21901779
56MP0003879_abnormal_hair_cell1.21118191
57MP0001529_abnormal_vocalization1.20902297
58MP0008789_abnormal_olfactory_epithelium1.19987158
59MP0002751_abnormal_autonomic_nervous1.18867535
60MP0002249_abnormal_larynx_morphology1.16550187
61MP0003890_abnormal_embryonic-extraembry1.11813736
62MP0002909_abnormal_adrenal_gland1.10957268
63MP0000538_abnormal_urinary_bladder1.08006977
64MP0003942_abnormal_urinary_system1.07023569
65MP0006072_abnormal_retinal_apoptosis1.04260229
66MP0003787_abnormal_imprinting1.03902231
67MP0005646_abnormal_pituitary_gland1.01657131
68MP0001348_abnormal_lacrimal_gland1.00758138
69MP0001501_abnormal_sleep_pattern0.99945286
70MP0001177_atelectasis0.99858884
71MP0004145_abnormal_muscle_electrophysio0.99184875
72MP0005187_abnormal_penis_morphology0.95272056
73MP0000026_abnormal_inner_ear0.94525036
74MP0003283_abnormal_digestive_organ0.92882415
75MP0001963_abnormal_hearing_physiology0.92342353
76MP0009379_abnormal_foot_pigmentation0.91026532
77MP0002069_abnormal_eating/drinking_beha0.91018617
78MP0003121_genomic_imprinting0.90632265
79MP0003119_abnormal_digestive_system0.90447271
80MP0003633_abnormal_nervous_system0.90336569
81MP0003137_abnormal_impulse_conducting0.89968773
82MP0003634_abnormal_glial_cell0.88212691
83MP0005551_abnormal_eye_electrophysiolog0.87289149
84MP0003938_abnormal_ear_development0.85835751
85MP0003123_paternal_imprinting0.84483636
86MP0004142_abnormal_muscle_tone0.84063000
87MP0005253_abnormal_eye_physiology0.82069481
88MP0002229_neurodegeneration0.81930501
89MP0008995_early_reproductive_senescence0.81754932
90MP0000534_abnormal_ureter_morphology0.80551191
91MP0000751_myopathy0.80282699
92MP0000462_abnormal_digestive_system0.79451304
93MP0002081_perinatal_lethality0.77594062
94MP0001299_abnormal_eye_distance/0.77587616
95MP0001943_abnormal_respiration0.75941075
96MP0003385_abnormal_body_wall0.75828608
97MP0004133_heterotaxia0.75509131
98MP0000015_abnormal_ear_pigmentation0.74617262
99MP0001905_abnormal_dopamine_level0.74594728
100MP0003937_abnormal_limbs/digits/tail_de0.72816481
101MP0004130_abnormal_muscle_cell0.71136664
102MP0010768_mortality/aging0.70981753
103MP0004085_abnormal_heartbeat0.70618277
104MP0005409_darkened_coat_color0.70191134
105MP0005377_hearing/vestibular/ear_phenot0.68757593
106MP0003878_abnormal_ear_physiology0.68757593
107MP0005195_abnormal_posterior_eye0.68192485
108MP0008877_abnormal_DNA_methylation0.66138437
109MP0000604_amyloidosis0.65439427
110MP0002082_postnatal_lethality0.65370675
111MP0010770_preweaning_lethality0.65370675
112MP0005248_abnormal_Harderian_gland0.64395819
113MP0003631_nervous_system_phenotype0.64289171
114MP0003632_abnormal_nervous_system0.64276936
115MP0001986_abnormal_taste_sensitivity0.63909606
116MP0000049_abnormal_middle_ear0.63192866
117MP0000681_abnormal_thyroid_gland0.63040403
118MP0010769_abnormal_survival0.62876288

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)4.67062674
2Myokymia (HP:0002411)4.57506032
3Mutism (HP:0002300)4.46052456
4Limb dystonia (HP:0002451)4.22987842
5Excessive salivation (HP:0003781)3.99369006
6Drooling (HP:0002307)3.99369006
7Amyotrophic lateral sclerosis (HP:0007354)3.97202698
8Cortical dysplasia (HP:0002539)3.73170373
9Focal seizures (HP:0007359)3.70334373
10Focal motor seizures (HP:0011153)3.69707158
11Supranuclear gaze palsy (HP:0000605)3.63455355
12Progressive cerebellar ataxia (HP:0002073)3.56228025
13Akinesia (HP:0002304)3.40504203
14Agitation (HP:0000713)3.38775564
15Broad-based gait (HP:0002136)3.37819594
16Abnormality of the corticospinal tract (HP:0002492)3.36098951
17Visual hallucinations (HP:0002367)3.35615038
18Epileptic encephalopathy (HP:0200134)3.34421710
19Aplasia/Hypoplasia of the brainstem (HP:0007362)3.33408646
20Hypoplasia of the brainstem (HP:0002365)3.33408646
21Pachygyria (HP:0001302)3.32629980
22Failure to thrive in infancy (HP:0001531)3.25723504
23Ankle clonus (HP:0011448)3.20169657
24Hemiparesis (HP:0001269)3.11416390
25Lissencephaly (HP:0001339)3.06542970
26Abnormal eating behavior (HP:0100738)3.03220552
27Sleep apnea (HP:0010535)2.97655147
28Poor eye contact (HP:0000817)2.96975936
29Febrile seizures (HP:0002373)2.93412510
30Morphological abnormality of the middle ear (HP:0008609)2.91827929
31Inappropriate behavior (HP:0000719)2.86843367
32Exotropia (HP:0000577)2.83687001
33Amblyopia (HP:0000646)2.79799663
34Action tremor (HP:0002345)2.66381091
35Morphological abnormality of the pyramidal tract (HP:0002062)2.60017391
36Abnormality of salivation (HP:0100755)2.59986527
37Obstructive sleep apnea (HP:0002870)2.48196676
38Abnormal social behavior (HP:0012433)2.46110351
39Impaired social interactions (HP:0000735)2.46110351
40Insidious onset (HP:0003587)2.45715603
41Termporal pattern (HP:0011008)2.45715603
42Hyperventilation (HP:0002883)2.44750737
43Genetic anticipation (HP:0003743)2.43802610
44Hypoventilation (HP:0002791)2.43325467
45Urinary urgency (HP:0000012)2.42231101
46Neurofibrillary tangles (HP:0002185)2.37857358
47Apathy (HP:0000741)2.36221599
48Papilledema (HP:0001085)2.35288728
49EEG with generalized epileptiform discharges (HP:0011198)2.34789704
50Generalized tonic-clonic seizures (HP:0002069)2.33761077
51Esotropia (HP:0000565)2.31636553
52Progressive inability to walk (HP:0002505)2.30727853
53Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30103453
54Hypsarrhythmia (HP:0002521)2.29653366
55Aqueductal stenosis (HP:0002410)2.29494742
56Inability to walk (HP:0002540)2.28103235
57Absence seizures (HP:0002121)2.27481626
58Epileptiform EEG discharges (HP:0011182)2.27080307
59Truncal ataxia (HP:0002078)2.25434328
60Fetal akinesia sequence (HP:0001989)2.24768624
61Shawl scrotum (HP:0000049)2.22438509
62Hypoplasia of the corpus callosum (HP:0002079)2.21399406
63Atonic seizures (HP:0010819)2.20254732
64Mild short stature (HP:0003502)2.19618039
65Intestinal atresia (HP:0011100)2.19504624
66Torticollis (HP:0000473)2.19499243
67Diplopia (HP:0000651)2.18524806
68Abnormality of binocular vision (HP:0011514)2.18524806
69Sacral dimple (HP:0000960)2.17458533
70Specific learning disability (HP:0001328)2.13863703
71Neonatal short-limb short stature (HP:0008921)2.13459836
72Cerebral inclusion bodies (HP:0100314)2.13307083
73Abnormality of the labia minora (HP:0012880)2.11592915
74Spastic gait (HP:0002064)2.11502068
75Urinary bladder sphincter dysfunction (HP:0002839)2.10680497
76Hemiplegia (HP:0002301)2.09868620
77Disinhibition (HP:0000734)2.09642159
78Diminished motivation (HP:0000745)2.09572372
79Hepatoblastoma (HP:0002884)2.08338107
80Vertebral arch anomaly (HP:0008438)2.07789039
81Absent speech (HP:0001344)2.07562453
82Gait imbalance (HP:0002141)2.06427531
83Open mouth (HP:0000194)2.02506750
84Dialeptic seizures (HP:0011146)2.01472175
85Stereotypic behavior (HP:0000733)2.00029988
86Sporadic (HP:0003745)1.97611185
87Insomnia (HP:0100785)1.96875357
88Impaired vibration sensation in the lower limbs (HP:0002166)1.96286608
89Protruding tongue (HP:0010808)1.94696610
90Elfin facies (HP:0004428)1.94615596
91Spastic tetraplegia (HP:0002510)1.94296494
92Lower limb muscle weakness (HP:0007340)1.92203274
93Focal dystonia (HP:0004373)1.91729802
94Pheochromocytoma (HP:0002666)1.91410071
95Abnormality of the ischium (HP:0003174)1.91288910
96Paraplegia (HP:0010550)1.91062363
97Shoulder girdle muscle weakness (HP:0003547)1.90432366
98Atrophy/Degeneration involving motor neurons (HP:0007373)1.90170286
99Spastic paraplegia (HP:0001258)1.88625972
100Ulnar claw (HP:0001178)1.86823065
101Large eyes (HP:0001090)1.86734493
102Abnormality of the lower motor neuron (HP:0002366)1.86575376
103Megalencephaly (HP:0001355)1.85678544
104Cutaneous syndactyly (HP:0012725)1.85541415
105Polymicrogyria (HP:0002126)1.84829368
106High anterior hairline (HP:0009890)1.84052928
107Hammertoe (HP:0001765)1.83158437
108Hyperacusis (HP:0010780)1.82482081
109Autism (HP:0000717)1.82431732
110Cutaneous finger syndactyly (HP:0010554)1.82083602
111Depression (HP:0000716)1.81326877
112Wide anterior fontanel (HP:0000260)1.79499370
113Turricephaly (HP:0000262)1.77561922
114Neuroendocrine neoplasm (HP:0100634)1.76298209
115Partial agenesis of the corpus callosum (HP:0001338)1.69572246
116Obsessive-compulsive behavior (HP:0000722)1.68771284
117Renal hypoplasia (HP:0000089)1.65050995
118Macroorchidism (HP:0000053)1.63455677
119Megalocornea (HP:0000485)1.62349231
120Dysdiadochokinesis (HP:0002075)1.60046229
121Vitreoretinal degeneration (HP:0000655)1.59342881
122Septo-optic dysplasia (HP:0100842)1.56652083
123Omphalocele (HP:0001539)1.54924046
124Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.54706908
125Infantile muscular hypotonia (HP:0008947)1.54689234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK18.09789795
2DYRK23.26212612
3MAP3K93.00913534
4MAPK132.94869906
5NTRK22.82844098
6WNK32.67389043
7PHKG12.53370384
8PHKG22.53370384
9SIK22.52123802
10MAP3K42.46955948
11MINK12.44032255
12MAP2K72.42254889
13EPHB22.25391488
14ERBB32.16153377
15NTRK32.15628918
16CASK2.10794046
17SIK31.80353320
18LATS21.74171880
19KSR11.67945467
20PAK61.66355111
21UHMK11.62989670
22TNIK1.57384178
23PNCK1.40003513
24DAPK21.32486854
25PRPF4B1.30157139
26CDK51.29889786
27MAP2K41.26936858
28CSNK1G21.26406518
29MARK21.16260509
30BCR1.13100134
31PKN11.08882200
32LIMK11.04769748
33DYRK1A0.99773420
34CSNK1G30.99191094
35EPHA40.95507254
36PRKCH0.93111973
37RPS6KA20.89905048
38CSNK1A1L0.87749479
39CDK180.86559013
40CAMK1G0.86286719
41MAP3K120.85063691
42PRKCZ0.84051720
43BRD40.83990702
44EPHA30.82254953
45CDK150.80146837
46CDK140.79086470
47ICK0.78871283
48PRKCG0.76359442
49PAK30.72452547
50CAMKK10.72037118
51RIPK10.71582619
52CDK11A0.71233323
53STK110.70978491
54EIF2AK20.70941923
55MAPK120.70512528
56MAP3K60.69232813
57PINK10.69190141
58PRKD30.66317743
59BMPR1B0.64499373
60CSNK1G10.63764860
61GRK50.63075915
62PLK20.62968190
63RET0.62889967
64STK38L0.61787480
65DDR20.61442432
66TYRO30.60647225
67LMTK20.60579348
68NTRK10.60076650
69SGK30.60064269
70ROCK20.58264485
71DAPK10.57393708
72FGFR20.56020581
73MAPK90.53904623
74MOS0.53218575
75ERBB20.50795860
76CAMK2A0.50683779
77SGK4940.48910332
78SGK2230.48910332
79FYN0.45855482
80ALK0.44645609
81YES10.42849329
82MAPK100.42141861
83PRKCE0.41901291
84IRAK20.40711662
85MAPK40.39859149
86DYRK1B0.38417583
87FES0.36659143
88PRKAA10.36313687
89MAPK80.35929949
90CAMK2D0.35898552
91ROCK10.35784061
92SGK10.35501343
93INSRR0.35040890
94TRIM280.34222284
95PRKACB0.33577440
96ADRBK10.33473881
97TAOK10.33317884
98CSNK1D0.32950378
99PRKG10.31871795
100PKN20.31542262
101SGK20.31333879
102MAP2K60.31318309
103PRKDC0.30793339
104MAPK150.30633425
105CAMK1D0.30444939
106RPS6KB10.28610505
107GSK3B0.28212590
108MKNK20.28010379
109CAMK2B0.27836699
110CDK190.27734719
111PDGFRA0.27305060
112RPS6KA30.27215776
113CAMK10.26848024
114CDK120.26648709
115PRKCB0.26445383
116FER0.26044121
117CCNB10.25551387
118CSNK1E0.25538344
119CAMKK20.24554888
120CDC42BPA0.23889489
121CAMK40.23568272
122PRKCI0.23073611
123GRK70.22486913
124KSR20.21427692
125TAOK20.20724734
126ILK0.19517051

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.55035148
2Axon guidance_Homo sapiens_hsa043602.76358408
3Synaptic vesicle cycle_Homo sapiens_hsa047212.61505227
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56699287
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41548011
6Glutamatergic synapse_Homo sapiens_hsa047242.34787205
7GABAergic synapse_Homo sapiens_hsa047272.29904227
8Circadian entrainment_Homo sapiens_hsa047132.20034964
9Morphine addiction_Homo sapiens_hsa050322.11466572
10Dopaminergic synapse_Homo sapiens_hsa047282.10189093
11Olfactory transduction_Homo sapiens_hsa047401.92091291
12Cholinergic synapse_Homo sapiens_hsa047251.90624885
13Taste transduction_Homo sapiens_hsa047421.88315533
14Serotonergic synapse_Homo sapiens_hsa047261.81459524
15Long-term potentiation_Homo sapiens_hsa047201.72800793
16Gap junction_Homo sapiens_hsa045401.72068299
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70586405
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.59982099
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59913925
20Insulin secretion_Homo sapiens_hsa049111.51381014
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50571275
22Long-term depression_Homo sapiens_hsa047301.49682201
23Phototransduction_Homo sapiens_hsa047441.48609620
24Endometrial cancer_Homo sapiens_hsa052131.44165720
25Amphetamine addiction_Homo sapiens_hsa050311.40842248
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40633533
27Cocaine addiction_Homo sapiens_hsa050301.39935275
28ErbB signaling pathway_Homo sapiens_hsa040121.38708534
29Salivary secretion_Homo sapiens_hsa049701.37830335
30Oxytocin signaling pathway_Homo sapiens_hsa049211.36931756
31Colorectal cancer_Homo sapiens_hsa052101.36603375
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33191284
33Renin secretion_Homo sapiens_hsa049241.31105508
34Type II diabetes mellitus_Homo sapiens_hsa049301.30313415
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28740214
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20920564
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20699065
38GnRH signaling pathway_Homo sapiens_hsa049121.19364467
39Cardiac muscle contraction_Homo sapiens_hsa042601.17949625
40Gastric acid secretion_Homo sapiens_hsa049711.14115366
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13788214
42Renal cell carcinoma_Homo sapiens_hsa052111.07993583
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03135586
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.03105940
45Calcium signaling pathway_Homo sapiens_hsa040201.03080540
46Estrogen signaling pathway_Homo sapiens_hsa049151.01269774
47Melanogenesis_Homo sapiens_hsa049160.99886500
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98169563
49Glioma_Homo sapiens_hsa052140.96535919
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95745217
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94028574
52MAPK signaling pathway_Homo sapiens_hsa040100.88688143
53Wnt signaling pathway_Homo sapiens_hsa043100.88155490
54Viral myocarditis_Homo sapiens_hsa054160.86901713
55cAMP signaling pathway_Homo sapiens_hsa040240.86270780
56Choline metabolism in cancer_Homo sapiens_hsa052310.83027213
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82090262
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80680595
59Dilated cardiomyopathy_Homo sapiens_hsa054140.78674186
60Ras signaling pathway_Homo sapiens_hsa040140.77624420
61Oocyte meiosis_Homo sapiens_hsa041140.76656451
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.75808049
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73382649
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71840004
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.71567996
66Basal cell carcinoma_Homo sapiens_hsa052170.69987644
67Hippo signaling pathway_Homo sapiens_hsa043900.69862408
68Butanoate metabolism_Homo sapiens_hsa006500.68791608
69Circadian rhythm_Homo sapiens_hsa047100.68627137
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68582993
71Insulin signaling pathway_Homo sapiens_hsa049100.68502597
72mTOR signaling pathway_Homo sapiens_hsa041500.68121536
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68014704
74Thyroid hormone synthesis_Homo sapiens_hsa049180.66183023
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66025492
76Alcoholism_Homo sapiens_hsa050340.64836464
77Bile secretion_Homo sapiens_hsa049760.64448190
78VEGF signaling pathway_Homo sapiens_hsa043700.62348441
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61491943
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61050772
81Hedgehog signaling pathway_Homo sapiens_hsa043400.60506093
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58657400
83Dorso-ventral axis formation_Homo sapiens_hsa043200.58226547
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58087342
85Tight junction_Homo sapiens_hsa045300.58021181
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57746868
87Rap1 signaling pathway_Homo sapiens_hsa040150.57301085
88AMPK signaling pathway_Homo sapiens_hsa041520.55996927
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55244898
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54253039
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54114743
92Phagosome_Homo sapiens_hsa041450.54000123
93Pancreatic secretion_Homo sapiens_hsa049720.53951802
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53864759
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53747600
96Protein digestion and absorption_Homo sapiens_hsa049740.50437777
97Alzheimers disease_Homo sapiens_hsa050100.50162336
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49990418
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49760770
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49605777
101Collecting duct acid secretion_Homo sapiens_hsa049660.49249465
102Prolactin signaling pathway_Homo sapiens_hsa049170.48836824
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48339357
104Melanoma_Homo sapiens_hsa052180.47913700
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.47427278
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45982466
107Non-small cell lung cancer_Homo sapiens_hsa052230.45709240
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44936309
109Endocytosis_Homo sapiens_hsa041440.44530238
110Prion diseases_Homo sapiens_hsa050200.44284362
111Ovarian steroidogenesis_Homo sapiens_hsa049130.43876644
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43299678
113Notch signaling pathway_Homo sapiens_hsa043300.43284266
114Adherens junction_Homo sapiens_hsa045200.39179029

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