TRIM68

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a 'really interesting new gene' (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.43611536
2response to pheromone (GO:0019236)5.52702259
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.29478586
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.29478586
5definitive hemopoiesis (GO:0060216)5.05811360
6behavioral response to nicotine (GO:0035095)4.73487768
7antigen processing and presentation of endogenous antigen (GO:0019883)4.68071106
8DNA deamination (GO:0045006)4.48899785
9pyrimidine nucleobase catabolic process (GO:0006208)4.41660331
10cellular ketone body metabolic process (GO:0046950)4.38274602
11positive regulation of gamma-delta T cell activation (GO:0046645)4.36758231
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.23067460
13ubiquinone biosynthetic process (GO:0006744)4.14494016
14ubiquinone metabolic process (GO:0006743)3.98202228
15ketone body metabolic process (GO:1902224)3.94029671
16valine metabolic process (GO:0006573)3.91080439
17epithelial cilium movement (GO:0003351)3.90028355
18fibroblast migration (GO:0010761)3.89570698
19L-fucose catabolic process (GO:0042355)3.83243469
20fucose catabolic process (GO:0019317)3.83243469
21L-fucose metabolic process (GO:0042354)3.83243469
22piRNA metabolic process (GO:0034587)3.77569460
23adaptation of signaling pathway (GO:0023058)3.75614421
24negative regulation of erythrocyte differentiation (GO:0045647)3.73535287
25regulation of gamma-delta T cell differentiation (GO:0045586)3.72249258
26preassembly of GPI anchor in ER membrane (GO:0016254)3.60545948
27megakaryocyte development (GO:0035855)3.60415383
28production of molecular mediator involved in inflammatory response (GO:0002532)3.56676738
29regulation of gamma-delta T cell activation (GO:0046643)3.47761208
30nucleobase catabolic process (GO:0046113)3.47196165
31regulation of cilium movement (GO:0003352)3.39481766
32DNA methylation involved in gamete generation (GO:0043046)3.35383279
33negative regulation of necroptotic process (GO:0060546)3.29178190
34cilium movement (GO:0003341)3.28124515
35platelet dense granule organization (GO:0060155)3.26171469
36protein complex biogenesis (GO:0070271)3.25935583
37gamma-aminobutyric acid transport (GO:0015812)3.24740761
38respiratory chain complex IV assembly (GO:0008535)3.23733065
39sarcomere organization (GO:0045214)3.23607859
40quinone biosynthetic process (GO:1901663)3.22957673
41axoneme assembly (GO:0035082)3.22858324
42cytochrome complex assembly (GO:0017004)3.18295479
43axonemal dynein complex assembly (GO:0070286)3.15009571
44positive regulation of tolerance induction (GO:0002645)3.14850671
45positive regulation of protein deacetylation (GO:0090312)3.14715911
46COPI coating of Golgi vesicle (GO:0048205)3.13844576
47Golgi transport vesicle coating (GO:0048200)3.13844576
48water-soluble vitamin biosynthetic process (GO:0042364)3.12872240
49positive thymic T cell selection (GO:0045059)3.12591950
50indolalkylamine metabolic process (GO:0006586)3.11273933
51tryptophan metabolic process (GO:0006568)3.09980681
52tryptophan catabolic process (GO:0006569)3.09680901
53indole-containing compound catabolic process (GO:0042436)3.09680901
54indolalkylamine catabolic process (GO:0046218)3.09680901
55negative regulation of necrotic cell death (GO:0060547)3.09398981
56endosome to melanosome transport (GO:0035646)3.08712365
57endosome to pigment granule transport (GO:0043485)3.08712365
58regulation of acrosome reaction (GO:0060046)3.05062190
59positive regulation of histone deacetylation (GO:0031065)3.03694028
60negative regulation of stress fiber assembly (GO:0051497)3.03453198
61response to interferon-beta (GO:0035456)3.03240608
62protein-cofactor linkage (GO:0018065)2.99066208
63cellular response to interferon-beta (GO:0035458)2.98999250
64regulation of hexokinase activity (GO:1903299)2.97973550
65regulation of glucokinase activity (GO:0033131)2.97973550
66regulation of necroptotic process (GO:0060544)2.97508805
67cilium or flagellum-dependent cell motility (GO:0001539)2.97368822
68creatine metabolic process (GO:0006600)2.96703387
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96468567
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.96468567
71NADH dehydrogenase complex assembly (GO:0010257)2.96468567
72GPI anchor metabolic process (GO:0006505)2.96451305
73multicellular organism reproduction (GO:0032504)2.95835941
74nonmotile primary cilium assembly (GO:0035058)2.92666200
75angiogenesis involved in wound healing (GO:0060055)2.92212332
76neural tube formation (GO:0001841)2.91554388
77polyol catabolic process (GO:0046174)2.89002664
78protein import into peroxisome matrix (GO:0016558)2.88785146
79regulation of interleukin-12 biosynthetic process (GO:0045075)2.88760525
80regulation of action potential (GO:0098900)2.88631870
81cilium morphogenesis (GO:0060271)2.85382082
82positive regulation of defense response to virus by host (GO:0002230)2.85154077
83antigen processing and presentation via MHC class Ib (GO:0002475)2.84875481
84negative regulation of phagocytosis (GO:0050765)2.84679319
85mitochondrial respiratory chain complex assembly (GO:0033108)2.81935358
86iron-sulfur cluster assembly (GO:0016226)2.81498045
87metallo-sulfur cluster assembly (GO:0031163)2.81498045
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81307731
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80709160
90kynurenine metabolic process (GO:0070189)2.80542028
91positive regulation of mitochondrial fission (GO:0090141)2.80091504
92positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.79679412
93protein K6-linked ubiquitination (GO:0085020)2.78822110
94regulation of sequestering of triglyceride (GO:0010889)2.78368139
95inositol phosphate catabolic process (GO:0071545)2.78030442
96hemidesmosome assembly (GO:0031581)2.75926108
97regulation of microtubule-based movement (GO:0060632)2.75051241
98neuronal action potential (GO:0019228)2.74847523
99glomerular filtration (GO:0003094)2.73078616
100cardiac myofibril assembly (GO:0055003)2.71846871
101fatty acid beta-oxidation (GO:0006635)2.71000021
102negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.70006217
103carnitine shuttle (GO:0006853)2.69640664
104retinal cone cell development (GO:0046549)2.68071782
105cornea development in camera-type eye (GO:0061303)2.66548925
106actin-myosin filament sliding (GO:0033275)2.65903788
107muscle filament sliding (GO:0030049)2.65903788
108positive regulation of prostaglandin secretion (GO:0032308)2.65788497
109regulation of calcium ion-dependent exocytosis (GO:0017158)2.64251623
110positive regulation of fatty acid transport (GO:2000193)2.63948916
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63301776
112negative regulation of telomere maintenance (GO:0032205)2.62640423
113cellular biogenic amine catabolic process (GO:0042402)2.61915181
114amine catabolic process (GO:0009310)2.61915181
115synaptic transmission, cholinergic (GO:0007271)2.61394270
116negative thymic T cell selection (GO:0045060)2.61031213
117negative regulation of mast cell activation (GO:0033004)2.58790201
118regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.57208473
119renal filtration (GO:0097205)2.55890084
120base-excision repair, AP site formation (GO:0006285)2.55092634
121phospholipid scrambling (GO:0017121)2.54794028
122positive regulation of organic acid transport (GO:0032892)2.54509992
123positive regulation of action potential (GO:0045760)2.54010082
124photoreceptor cell maintenance (GO:0045494)2.53997369
125positive regulation of natural killer cell differentiation (GO:0032825)2.53907088
126regulation of necrotic cell death (GO:0010939)2.53635599
127lymph node development (GO:0048535)2.53504982
128positive regulation of B cell differentiation (GO:0045579)2.51538435
129regulation of tolerance induction (GO:0002643)2.51318961
130GPI anchor biosynthetic process (GO:0006506)2.50381911
131kidney morphogenesis (GO:0060993)2.50253841
132L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48578573
133membrane raft organization (GO:0031579)2.48345370
134heart process (GO:0003015)2.47799408
135heart contraction (GO:0060047)2.47799408
136RNA destabilization (GO:0050779)2.47725605
137thioester biosynthetic process (GO:0035384)2.47698275
138acyl-CoA biosynthetic process (GO:0071616)2.47698275
139exogenous drug catabolic process (GO:0042738)2.47603031
140intracellular protein transmembrane import (GO:0044743)2.46137839
141regulation of nuclear cell cycle DNA replication (GO:0033262)2.45932928
142secretory granule organization (GO:0033363)2.45784635
143growth hormone receptor signaling pathway (GO:0060396)2.45623478
144regulation of RIG-I signaling pathway (GO:0039535)2.45470212
145B cell receptor signaling pathway (GO:0050853)2.45419998
146negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.44555141
147calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44173293
148thymic T cell selection (GO:0045061)2.44110585
149photoreceptor cell development (GO:0042461)2.43560422
150quinone metabolic process (GO:1901661)2.43389806
151hepatocyte apoptotic process (GO:0097284)2.43356973
152protein localization to Golgi apparatus (GO:0034067)2.43199401
153DNA double-strand break processing (GO:0000729)2.42694415
154intraciliary transport (GO:0042073)2.42165756
155pseudouridine synthesis (GO:0001522)2.41673529
156positive regulation of amino acid transport (GO:0051957)2.40875992
157negative T cell selection (GO:0043383)2.40873472
158NIK/NF-kappaB signaling (GO:0038061)2.40509077
159tRNA modification (GO:0006400)2.38721160
160positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.37753144
161positive regulation of urine volume (GO:0035810)2.37377124
162cellular response to zinc ion (GO:0071294)2.36821870
163behavioral response to ethanol (GO:0048149)2.36145339
164tricarboxylic acid metabolic process (GO:0072350)2.35579616
165establishment of protein localization to Golgi (GO:0072600)2.34399491
166anterograde synaptic vesicle transport (GO:0048490)2.34244348
167single strand break repair (GO:0000012)2.34166238
168negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33974327
169branched-chain amino acid catabolic process (GO:0009083)2.33944794
170pinocytosis (GO:0006907)2.33758710
171myofibril assembly (GO:0030239)2.33146695
172fatty acid transmembrane transport (GO:1902001)2.32343727
173exocrine pancreas development (GO:0031017)2.31655537
174response to muramyl dipeptide (GO:0032495)2.30699636
175pentose-phosphate shunt (GO:0006098)2.30359621
176fatty acid catabolic process (GO:0009062)2.29733818
177signal peptide processing (GO:0006465)2.29327431
1783-UTR-mediated mRNA stabilization (GO:0070935)2.28116386
179actin-mediated cell contraction (GO:0070252)2.27039666
180cellular response to growth hormone stimulus (GO:0071378)2.26317533
181regulation of mRNA catabolic process (GO:0061013)2.25593301
182regulation of relaxation of muscle (GO:1901077)2.25538780
183branched-chain amino acid metabolic process (GO:0009081)2.25266705
184virion attachment to host cell (GO:0019062)2.25109894
185adhesion of symbiont to host cell (GO:0044650)2.25109894
186actomyosin structure organization (GO:0031032)2.23530769
187positive regulation of transcription regulatory region DNA binding (GO:2000679)2.23402978
188gland morphogenesis (GO:0022612)2.23119438
189cell proliferation involved in metanephros development (GO:0072203)2.22923180
190fatty acid oxidation (GO:0019395)2.21920253
191bundle of His cell to Purkinje myocyte communication (GO:0086069)2.21773900
192cardiac muscle contraction (GO:0060048)2.21544953
193heparin metabolic process (GO:0030202)2.20475939
194heparin biosynthetic process (GO:0030210)2.20475939
195lipid particle organization (GO:0034389)2.19327008
196vesicle fusion (GO:0006906)2.19159369
197positive regulation of mRNA catabolic process (GO:0061014)2.19119753
198positive regulation of fatty acid oxidation (GO:0046321)2.18517936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela5.73298251
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.51474135
3EZH2_22144423_ChIP-Seq_EOC_Human3.89884529
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.57377248
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.50245566
6SCL_19346495_ChIP-Seq_HPC-7_Human3.02025257
7E2F7_22180533_ChIP-Seq_HELA_Human2.89321311
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82387218
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.80214890
10VDR_22108803_ChIP-Seq_LS180_Human2.79529505
11CLOCK_20551151_ChIP-Seq_293T_Human2.60572516
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49683317
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.48114372
14GATA1_22025678_ChIP-Seq_K562_Human2.44948531
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43506294
16GBX2_23144817_ChIP-Seq_PC3_Human2.39112295
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.36905710
18IGF1R_20145208_ChIP-Seq_DFB_Human2.35520917
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27256733
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.26368157
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.21422576
22VDR_21846776_ChIP-Seq_THP-1_Human2.19961655
23RUNX_20019798_ChIP-Seq_JUKART_Human2.16744849
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16372681
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14769205
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11496834
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04473131
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02284344
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97879845
30MYC_22102868_ChIP-Seq_BL_Human1.96732544
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95559253
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94528271
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92613522
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85020822
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.84581472
36MAF_26560356_Chip-Seq_TH1_Human1.84515794
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.84146733
38* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83601534
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.83222640
40EWS_26573619_Chip-Seq_HEK293_Human1.81014480
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80646755
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78856364
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77106124
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.73432149
45VDR_23849224_ChIP-Seq_CD4+_Human1.73367556
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.73342593
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73072964
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72360056
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72279660
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71359877
51IRF1_19129219_ChIP-ChIP_H3396_Human1.70395807
52TCF7_22412390_ChIP-Seq_EML_Mouse1.68925341
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68662535
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65318690
55VDR_24763502_ChIP-Seq_THP-1_Human1.65300200
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64733201
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.64661204
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64633281
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63041697
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62874764
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60209027
62MYB_26560356_Chip-Seq_TH2_Human1.60062365
63TP53_22573176_ChIP-Seq_HFKS_Human1.57675978
64FUS_26573619_Chip-Seq_HEK293_Human1.57324364
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56160727
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.54886370
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54243994
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.51995991
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.51995991
70MYB_26560356_Chip-Seq_TH1_Human1.51609534
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.51293704
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50723522
73P300_19829295_ChIP-Seq_ESCs_Human1.50626033
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.49653893
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48000418
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47942145
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.47682496
78UTX_26944678_Chip-Seq_JUKART_Human1.47627465
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.46818953
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44821095
81AR_20517297_ChIP-Seq_VCAP_Human1.42034332
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41952733
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39843861
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39629510
85SPI1_23547873_ChIP-Seq_NB4_Human1.39183937
86TAF15_26573619_Chip-Seq_HEK293_Human1.38868624
87MYC_18940864_ChIP-ChIP_HL60_Human1.38314400
88CIITA_25753668_ChIP-Seq_RAJI_Human1.37780230
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37646685
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37638339
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36486922
92AR_21572438_ChIP-Seq_LNCaP_Human1.36339952
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35880360
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35000793
95REST_21632747_ChIP-Seq_MESCs_Mouse1.33553683
96SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33494491
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33328069
98CBP_20019798_ChIP-Seq_JUKART_Human1.33328069
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.32266510
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30673881
101FOXP3_21729870_ChIP-Seq_TREG_Human1.29475930
102PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29425047
103RUNX1_22412390_ChIP-Seq_EML_Mouse1.28091100
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27305734
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24852918
106ELK1_19687146_ChIP-ChIP_HELA_Human1.24279568
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.24094357
108AR_25329375_ChIP-Seq_VCAP_Human1.23522915
109PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23422122
110ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23185612
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22723488
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22397027
113GATA3_27048872_Chip-Seq_THYMUS_Human1.21951039
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21724639
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21215190
116BCAT_22108803_ChIP-Seq_LS180_Human1.20598354
117NCOR_22424771_ChIP-Seq_293T_Human1.20508891
118GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19590557
119STAT3_23295773_ChIP-Seq_U87_Human1.19438464
120EP300_21415370_ChIP-Seq_HL-1_Mouse1.18906414
121* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18892611
122* FOXA1_25329375_ChIP-Seq_VCAP_Human1.18892611
123IRF8_27001747_Chip-Seq_BMDM_Mouse1.18150193
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17563213
125NANOG_19829295_ChIP-Seq_ESCs_Human1.17506343
126SOX2_19829295_ChIP-Seq_ESCs_Human1.17506343
127TCF4_22108803_ChIP-Seq_LS180_Human1.16768921
128STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16208839
129GATA1_19941826_ChIP-Seq_K562_Human1.15760775
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15407094
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15201403
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14699489
133MYC_19829295_ChIP-Seq_ESCs_Human1.14015726
134SPI1_23127762_ChIP-Seq_K562_Human1.13924844
135RUNX2_22187159_ChIP-Seq_PCA_Human1.13624800
136TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13581092
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12467577
138ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12387858
139PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11718410
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11704842
141SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11704842
142ER_23166858_ChIP-Seq_MCF-7_Human1.11507390
143TCF4_23295773_ChIP-Seq_U87_Human1.11161858
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10940471
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10187280
146STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09740010
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09311816
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09303034
149SMAD4_21799915_ChIP-Seq_A2780_Human1.09274827
150SALL1_21062744_ChIP-ChIP_HESCs_Human1.09053264
151RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08132396
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07824643
153PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07633036
154EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07500368
155FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07355905
156EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07059757
157NANOG_20526341_ChIP-Seq_ESCs_Human1.06826742
158BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05882481
159STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05855834
160KDM2B_26808549_Chip-Seq_DND41_Human1.05290719
161UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04820127
162KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04405586
163P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04239563
164PIAS1_25552417_ChIP-Seq_VCAP_Human1.04102149
165EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02858939
166SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02264199
167PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00772876
168TAF2_19829295_ChIP-Seq_ESCs_Human1.00546214
169RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99479965
170* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.99059928
171REST_18959480_ChIP-ChIP_MESCs_Mouse0.99019580
172CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98768072
173KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97941448
174PRDM14_20953172_ChIP-Seq_ESCs_Human0.97933084
175FOXH1_21741376_ChIP-Seq_ESCs_Human0.97767457
176* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97754183
177SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97623058
178AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97309560
179GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97247307
180ERA_21632823_ChIP-Seq_H3396_Human0.97137699
181NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97102364
182GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96514522
183PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96046536
184FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95578551
185TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95441858
186CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94079834
187TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93863297
188HOXB7_26014856_ChIP-Seq_BT474_Human0.93858797
189SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93787976
190MAF_26560356_Chip-Seq_TH2_Human0.93276952
191CDX2_22108803_ChIP-Seq_LS180_Human0.93187380
192PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93179831
193SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92840326
194FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92571138
195GATA3_26560356_Chip-Seq_TH2_Human0.91867145
196KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91621511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.54076508
2MP0003183_abnormal_peptide_metabolism3.68995342
3MP0000372_irregular_coat_pigmentation3.28122165
4MP0008877_abnormal_DNA_methylation3.21330284
5MP0002102_abnormal_ear_morphology3.11217760
6MP0005645_abnormal_hypothalamus_physiol3.02468561
7MP0002653_abnormal_ependyma_morphology2.94464858
8MP0004084_abnormal_cardiac_muscle2.89175722
9MP0005174_abnormal_tail_pigmentation2.69770723
10MP0004130_abnormal_muscle_cell2.66076643
11MP0002396_abnormal_hematopoietic_system2.47080769
12MP0002166_altered_tumor_susceptibility2.43638338
13MP0005646_abnormal_pituitary_gland2.26770751
14MP0005670_abnormal_white_adipose2.25043653
15MP0004036_abnormal_muscle_relaxation2.21349780
16MP0000015_abnormal_ear_pigmentation2.13686168
17MP0004043_abnormal_pH_regulation2.11485175
18MP0005551_abnormal_eye_electrophysiolog2.06923424
19MP0005075_abnormal_melanosome_morpholog2.00656244
20MP0002163_abnormal_gland_morphology1.99229534
21MP0000685_abnormal_immune_system1.98447665
22MP0003787_abnormal_imprinting1.93935930
23MP0010630_abnormal_cardiac_muscle1.91443800
24MP0004808_abnormal_hematopoietic_stem1.88729670
25MP0000751_myopathy1.87627995
26MP0001968_abnormal_touch/_nociception1.86056178
27MP0000749_muscle_degeneration1.83754576
28MP0008875_abnormal_xenobiotic_pharmacok1.80459243
29MP0006072_abnormal_retinal_apoptosis1.79042163
30MP0009384_cardiac_valve_regurgitation1.77345841
31MP0004264_abnormal_extraembryonic_tissu1.76294269
32MP0005253_abnormal_eye_physiology1.73696480
33MP0000465_gastrointestinal_hemorrhage1.72646732
34MP0002009_preneoplasia1.72376841
35MP0003763_abnormal_thymus_physiology1.72367786
36MP0002234_abnormal_pharynx_morphology1.72098979
37MP0002876_abnormal_thyroid_physiology1.72058419
38MP0002006_tumorigenesis1.68629275
39MP0001984_abnormal_olfaction1.67831936
40MP0002837_dystrophic_cardiac_calcinosis1.67823396
41MP0005167_abnormal_blood-brain_barrier1.65348273
42MP0008872_abnormal_physiological_respon1.64614035
43MP0009745_abnormal_behavioral_response1.64160700
44MP0005666_abnormal_adipose_tissue1.63638331
45MP0002735_abnormal_chemical_nociception1.63399279
46MP0005330_cardiomyopathy1.61483121
47MP0004087_abnormal_muscle_fiber1.58144629
48MP0003136_yellow_coat_color1.53393068
49MP0008995_early_reproductive_senescence1.52753588
50MP0003195_calcinosis1.48222633
51MP0004185_abnormal_adipocyte_glucose1.48193739
52MP0006054_spinal_hemorrhage1.45491995
53MP0001835_abnormal_antigen_presentation1.45468948
54MP0005385_cardiovascular_system_phenoty1.45428525
55MP0001544_abnormal_cardiovascular_syste1.45428525
56MP0002272_abnormal_nervous_system1.45282853
57MP0002938_white_spotting1.43165053
58MP0002095_abnormal_skin_pigmentation1.42846945
59MP0003567_abnormal_fetal_cardiomyocyte1.41548050
60MP0009046_muscle_twitch1.41494638
61MP0002638_abnormal_pupillary_reflex1.40899645
62MP0002972_abnormal_cardiac_muscle1.40807921
63MP0004142_abnormal_muscle_tone1.40594150
64MP0001501_abnormal_sleep_pattern1.40519388
65MP0003646_muscle_fatigue1.39176807
66MP0003172_abnormal_lysosome_physiology1.39042634
67MP0002796_impaired_skin_barrier1.36755558
68MP0005375_adipose_tissue_phenotype1.35208305
69MP0001986_abnormal_taste_sensitivity1.34669646
70MP0003011_delayed_dark_adaptation1.34645021
71MP0001346_abnormal_lacrimal_gland1.34518421
72MP0008058_abnormal_DNA_repair1.31691720
73MP0002127_abnormal_cardiovascular_syste1.31497315
74MP0002736_abnormal_nociception_after1.30454159
75MP0000383_abnormal_hair_follicle1.29136774
76MP0002060_abnormal_skin_morphology1.29005519
77MP0006276_abnormal_autonomic_nervous1.28931757
78MP0005084_abnormal_gallbladder_morpholo1.28651416
79MP0003718_maternal_effect1.26008502
80MP0002277_abnormal_respiratory_mucosa1.25830478
81MP0005620_abnormal_muscle_contractility1.25651734
82MP0001970_abnormal_pain_threshold1.21988351
83MP0004885_abnormal_endolymph1.20264158
84MP0003880_abnormal_central_pattern1.20183503
85MP0005379_endocrine/exocrine_gland_phen1.19592033
86MP0006138_congestive_heart_failure1.17717345
87MP0000631_abnormal_neuroendocrine_gland1.17538281
88MP0003828_pulmonary_edema1.17499216
89MP0001485_abnormal_pinna_reflex1.16589509
90MP0002572_abnormal_emotion/affect_behav1.15690434
91MP0006292_abnormal_olfactory_placode1.14735005
92MP0003950_abnormal_plasma_membrane1.14661976
93MP0002106_abnormal_muscle_physiology1.14380402
94MP0004742_abnormal_vestibular_system1.13830441
95MP0010678_abnormal_skin_adnexa1.13693736
96MP0003566_abnormal_cell_adhesion1.13511431
97MP0001853_heart_inflammation1.12629249
98MP0010234_abnormal_vibrissa_follicle1.12288192
99MP0002254_reproductive_system_inflammat1.12281253
100MP0004215_abnormal_myocardial_fiber1.12052944
101MP0002877_abnormal_melanocyte_morpholog1.11705888
102MP0000003_abnormal_adipose_tissue1.11217796
103MP0005058_abnormal_lysosome_morphology1.11016807
104MP0001270_distended_abdomen1.10455564
105MP0003121_genomic_imprinting1.09803754
106MP0008438_abnormal_cutaneous_collagen1.08937580
107MP0004272_abnormal_basement_membrane1.07438065
108MP0009764_decreased_sensitivity_to1.06911798
109MP0001919_abnormal_reproductive_system1.06860280
110MP0009278_abnormal_bone_marrow1.05489435
111MP0005386_behavior/neurological_phenoty1.05436421
112MP0004924_abnormal_behavior1.05436421
113MP0001529_abnormal_vocalization1.05355327
114MP0004145_abnormal_muscle_electrophysio1.04870367
115MP0004133_heterotaxia1.04429052
116MP0003122_maternal_imprinting1.04198264
117MP0004947_skin_inflammation1.04028501
118MP0000733_abnormal_muscle_development1.02787231
119MP0001800_abnormal_humoral_immune1.01699328
120MP0003279_aneurysm1.00778288
121MP0002229_neurodegeneration0.98820826
122MP0001324_abnormal_eye_pigmentation0.98199867
123MP0008775_abnormal_heart_ventricle0.98039154
124MP0000343_altered_response_to0.97930074
125MP0002063_abnormal_learning/memory/cond0.97060646
126MP0002557_abnormal_social/conspecific_i0.96913238
127MP0002064_seizures0.95974332
128MP0005085_abnormal_gallbladder_physiolo0.95916261
129MP0001905_abnormal_dopamine_level0.95505040
130MP0010386_abnormal_urinary_bladder0.93188478
131MP0003635_abnormal_synaptic_transmissio0.92805968
132MP0003300_gastrointestinal_ulcer0.92789312
133MP0002067_abnormal_sensory_capabilities0.91946103
134MP0008789_abnormal_olfactory_epithelium0.91803700
135MP0002733_abnormal_thermal_nociception0.91801886
136MP0003123_paternal_imprinting0.91007870
137MP0005647_abnormal_sex_gland0.90788857
138MP0001849_ear_inflammation0.90719037
139MP0000767_abnormal_smooth_muscle0.90600089
140MP0010155_abnormal_intestine_physiology0.90129364
141MP0005389_reproductive_system_phenotype0.89560143
142MP0005408_hypopigmentation0.89087270
143MP0000371_diluted_coat_color0.89068305
144MP0003186_abnormal_redox_activity0.88945712
145MP0005387_immune_system_phenotype0.87891128
146MP0001790_abnormal_immune_system0.87891128
147MP0005464_abnormal_platelet_physiology0.87750317
148MP0002398_abnormal_bone_marrow0.87488454
149MP0000613_abnormal_salivary_gland0.87144937
150MP0002420_abnormal_adaptive_immunity0.85958259
151MP0004782_abnormal_surfactant_physiolog0.85936504
152MP0002452_abnormal_antigen_presenting0.85641607
153MP0003698_abnormal_male_reproductive0.85387717
154MP0005275_abnormal_skin_tensile0.84980022
155MP0000490_abnormal_crypts_of0.84004956
156MP0001873_stomach_inflammation0.83911745
157MP0003221_abnormal_cardiomyocyte_apopto0.83434956
158MP0002160_abnormal_reproductive_system0.83366307
159MP0005499_abnormal_olfactory_system0.83139475
160MP0005394_taste/olfaction_phenotype0.83139475
161MP0001881_abnormal_mammary_gland0.82903710
162MP0003436_decreased_susceptibility_to0.82290824
163MP0002138_abnormal_hepatobiliary_system0.82064275
164MP0004147_increased_porphyrin_level0.81228670
165MP0001929_abnormal_gametogenesis0.81174095
166MP0005671_abnormal_response_to0.80936197
167MP0000266_abnormal_heart_morphology0.80791658
168MP0001819_abnormal_immune_cell0.80514260
169MP0005369_muscle_phenotype0.79988174
170MP0000759_abnormal_skeletal_muscle0.79930972
171MP0000716_abnormal_immune_system0.78912682
172MP0008961_abnormal_basal_metabolism0.78734373
173MP0001879_abnormal_lymphatic_vessel0.78244218
174MP0005171_absent_coat_pigmentation0.78118191
175MP0005451_abnormal_body_composition0.77977455
176MP0000750_abnormal_muscle_regeneration0.77304310
177MP0003943_abnormal_hepatobiliary_system0.77188434
178MP0000689_abnormal_spleen_morphology0.77111631
179MP0001502_abnormal_circadian_rhythm0.77024074
180MP0005023_abnormal_wound_healing0.76807788
181MP0000778_abnormal_nervous_system0.76388757
182MP0001764_abnormal_homeostasis0.75969617
183MP0000013_abnormal_adipose_tissue0.75864388
184MP0002269_muscular_atrophy0.75026910
185MP0001666_abnormal_nutrient_absorption0.74770771
186MP0002723_abnormal_immune_serum0.74380913
187MP0002429_abnormal_blood_cell0.74132608
188MP0002128_abnormal_blood_circulation0.73815040
189MP0005410_abnormal_fertilization0.72850602
190MP0000427_abnormal_hair_cycle0.72764183
191MP0003866_abnormal_defecation0.72068211
192MP0005195_abnormal_posterior_eye0.72057985
193MP0005377_hearing/vestibular/ear_phenot0.71707404
194MP0003878_abnormal_ear_physiology0.71707404

Predicted human phenotypes

RankGene SetZ-score
1Abnormal delayed hypersensitivity skin test (HP:0002963)5.05378592
2Pancreatic cysts (HP:0001737)4.45775075
3Pancreatic fibrosis (HP:0100732)4.13253361
4True hermaphroditism (HP:0010459)3.72222174
5Right ventricular cardiomyopathy (HP:0011663)3.66757380
6Abnormality of the renal cortex (HP:0011035)3.57532233
7Chronic otitis media (HP:0000389)3.50741368
8Nephronophthisis (HP:0000090)3.39496140
9Ventricular tachycardia (HP:0004756)3.33750531
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.32814148
11Absent/shortened dynein arms (HP:0200106)3.32814148
12Renal cortical cysts (HP:0000803)3.30311490
13Molar tooth sign on MRI (HP:0002419)3.24506300
14Abnormality of midbrain morphology (HP:0002418)3.24506300
15Type II lissencephaly (HP:0007260)3.23691528
16Lissencephaly (HP:0001339)3.23521032
173-Methylglutaconic aciduria (HP:0003535)3.17247936
18Pendular nystagmus (HP:0012043)3.16141339
19Abnormality of the renal medulla (HP:0100957)3.14689627
20Ankle contracture (HP:0006466)3.14659080
21Congenital stationary night blindness (HP:0007642)3.14565514
22Abnormal respiratory epithelium morphology (HP:0012253)3.14003646
23Abnormal respiratory motile cilium morphology (HP:0005938)3.14003646
24Abnormality of T cell physiology (HP:0011840)3.10138633
25Myoglobinuria (HP:0002913)3.03037992
26Medial flaring of the eyebrow (HP:0010747)2.98872834
27Lipoatrophy (HP:0100578)2.97202815
28Hyporeflexia of lower limbs (HP:0002600)2.92696380
29Tubular atrophy (HP:0000092)2.89843085
30Methylmalonic aciduria (HP:0012120)2.88431590
31Recurrent bronchitis (HP:0002837)2.84568202
32Nephrogenic diabetes insipidus (HP:0009806)2.82009507
33Recurrent viral infections (HP:0004429)2.80970591
34Abnormal biliary tract physiology (HP:0012439)2.80171876
35Bile duct proliferation (HP:0001408)2.80171876
36Hyperventilation (HP:0002883)2.80042653
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.75982579
38Agammaglobulinemia (HP:0004432)2.71304098
39Cystic liver disease (HP:0006706)2.69275692
40Gait imbalance (HP:0002141)2.67874947
41Abnormal foot bone ossification (HP:0010675)2.63534926
42Calf muscle hypertrophy (HP:0008981)2.62739865
43Dilated cardiomyopathy (HP:0001644)2.62224736
44Abnormality of T cell number (HP:0011839)2.61031894
45Abolished electroretinogram (ERG) (HP:0000550)2.59580526
46Abnormal ciliary motility (HP:0012262)2.58182914
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56976019
48Congenital primary aphakia (HP:0007707)2.53321870
49Abnormal respiratory motile cilium physiology (HP:0012261)2.51592221
50Increased connective tissue (HP:0009025)2.47685451
51Increased muscle lipid content (HP:0009058)2.46865895
52Tubulointerstitial nephritis (HP:0001970)2.46053399
53Abnormal rod and cone electroretinograms (HP:0008323)2.45507811
54Attenuation of retinal blood vessels (HP:0007843)2.44495792
55Exercise-induced myalgia (HP:0003738)2.44251585
56Chronic mucocutaneous candidiasis (HP:0002728)2.43077285
57Recurrent cutaneous fungal infections (HP:0011370)2.43077285
58Congenital hepatic fibrosis (HP:0002612)2.42260149
59Hematochezia (HP:0002573)2.41739627
60Exercise-induced muscle cramps (HP:0003710)2.41070631
61Thrombocytosis (HP:0001894)2.39676823
62Broad metatarsal (HP:0001783)2.36965312
63Gastrointestinal stroma tumor (HP:0100723)2.35949783
64Abnormality of fatty-acid metabolism (HP:0004359)2.35051252
65Atrial fibrillation (HP:0005110)2.34320467
66Aortic aneurysm (HP:0004942)2.34161634
67Abnormal drinking behavior (HP:0030082)2.32489911
68Polydipsia (HP:0001959)2.32489911
69Progressive inability to walk (HP:0002505)2.31494732
70Muscle hypertrophy of the lower extremities (HP:0008968)2.31038153
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.30074449
72Asymmetric septal hypertrophy (HP:0001670)2.29898834
73Colon cancer (HP:0003003)2.27954978
74Facial diplegia (HP:0001349)2.27565111
75Albinism (HP:0001022)2.27252669
76Muscle fiber splitting (HP:0003555)2.26690214
77Focal motor seizures (HP:0011153)2.24712539
78IgM deficiency (HP:0002850)2.23989585
79T lymphocytopenia (HP:0005403)2.23066457
80Abnormality of the calf musculature (HP:0001430)2.21806929
81Broad face (HP:0000283)2.21013736
82Aplastic anemia (HP:0001915)2.19492386
83Inability to walk (HP:0002540)2.18701432
84Autoimmune thrombocytopenia (HP:0001973)2.17954860
85Colitis (HP:0002583)2.17752828
86Spontaneous hematomas (HP:0007420)2.17670313
87Gaze-evoked nystagmus (HP:0000640)2.16380428
88Mitochondrial inheritance (HP:0001427)2.13606202
89Abnormality of the pons (HP:0007361)2.13400144
90Abnormality of the left ventricular outflow tract (HP:0011103)2.12870950
91Subaortic stenosis (HP:0001682)2.12870950
92Hypoglycemic coma (HP:0001325)2.11571640
93Inflammation of the large intestine (HP:0002037)2.11417513
94Sclerocornea (HP:0000647)2.10457184
95Difficulty running (HP:0009046)2.10371752
96Palpitations (HP:0001962)2.10334689
97Carpal bone hypoplasia (HP:0001498)2.09650014
98Progressive microcephaly (HP:0000253)2.09512776
99Ketosis (HP:0001946)2.08564785
100Stridor (HP:0010307)2.07586701
101Hemiparesis (HP:0001269)2.07196747
102Primary atrial arrhythmia (HP:0001692)2.07153306
103Gastrointestinal inflammation (HP:0004386)2.06705721
104Fair hair (HP:0002286)2.05941555
105Pachygyria (HP:0001302)2.05653947
106Sudden death (HP:0001699)2.05381166
107Tubulointerstitial abnormality (HP:0001969)2.05279445
108Abnormality of T cells (HP:0002843)2.04622858
109Elevated erythrocyte sedimentation rate (HP:0003565)2.03741388
110Generalized aminoaciduria (HP:0002909)2.03562670
111Increased CSF lactate (HP:0002490)2.03545941
112Aortic dissection (HP:0002647)2.02668444
113Pancreatic islet-cell hyperplasia (HP:0004510)2.01883629
114Supraventricular arrhythmia (HP:0005115)2.00438591
115Hypoplasia of the pons (HP:0012110)2.00252234
116Chronic sinusitis (HP:0011109)1.99449988
117Supraventricular tachycardia (HP:0004755)1.99311064
118Anencephaly (HP:0002323)1.97859854
11911 pairs of ribs (HP:0000878)1.96523428
120Polyuria (HP:0000103)1.96307700
121Rhinitis (HP:0012384)1.96276076
122Cellulitis (HP:0100658)1.96026694
123Aplasia/hypoplasia of the uterus (HP:0008684)1.95893527
124Brushfield spots (HP:0001088)1.95793950
125Distal lower limb muscle weakness (HP:0009053)1.95748100
126Vaginal atresia (HP:0000148)1.94543935
127Genital tract atresia (HP:0001827)1.93756291
128Lipid accumulation in hepatocytes (HP:0006561)1.93381131
129Abnormality of oral frenula (HP:0000190)1.92478934
130Limb-girdle muscle atrophy (HP:0003797)1.92384297
131Cerebellar dysplasia (HP:0007033)1.92134671
132Interstitial pulmonary disease (HP:0006530)1.91421325
133Petechiae (HP:0000967)1.91347656
134Abnormality of the nasal mucosa (HP:0000433)1.90259948
135Agitation (HP:0000713)1.89008871
136Aplasia/Hypoplasia of the spleen (HP:0010451)1.88282518
137Increased hepatocellular lipid droplets (HP:0006565)1.87816667
138Fatigue (HP:0012378)1.87555868
139Dicarboxylic aciduria (HP:0003215)1.86980614
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86980614
141Furrowed tongue (HP:0000221)1.85030232
142Methylmalonic acidemia (HP:0002912)1.84880950
143Ketoacidosis (HP:0001993)1.84647550
144Occipital encephalocele (HP:0002085)1.84596210
145Abnormality of alanine metabolism (HP:0010916)1.84190838
146Hyperalaninemia (HP:0003348)1.84190838
147Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84190838
148Increased serum lactate (HP:0002151)1.83721513
149Polyphagia (HP:0002591)1.83611791
150Flat acetabular roof (HP:0003180)1.83420418
151Acute myeloid leukemia (HP:0004808)1.83201086
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.81776399
153Chronic hepatic failure (HP:0100626)1.81343556
154Optic nerve hypoplasia (HP:0000609)1.80757243
155Decreased central vision (HP:0007663)1.78310525
156Periodontitis (HP:0000704)1.77939304
157Asplenia (HP:0001746)1.77740883
158Broad-based gait (HP:0002136)1.77043695
159Absent speech (HP:0001344)1.76848791
160Nasal polyposis (HP:0100582)1.76846481
161Recurrent skin infections (HP:0001581)1.76600316
162Respiratory difficulties (HP:0002880)1.76420341
163Retinal dysplasia (HP:0007973)1.75629515
164Papilledema (HP:0001085)1.75368804
165Stomatitis (HP:0010280)1.75307801
166Increased intramyocellular lipid droplets (HP:0012240)1.74739769
167Hepatic necrosis (HP:0002605)1.74140306
168Milia (HP:0001056)1.73296077
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73280482
170Large for gestational age (HP:0001520)1.72813874
171Abnormality of endocrine pancreas physiology (HP:0012093)1.72292806
172Abnormality of the pancreatic islet cells (HP:0006476)1.72292806
173Generalized hypopigmentation of hair (HP:0011358)1.71548570
174Osteolytic defects of the hand bones (HP:0009699)1.71462482
175Osteolytic defects of the phalanges of the hand (HP:0009771)1.71462482
176Aplasia/Hypoplasia involving the musculature (HP:0001460)1.71402500
177Tachypnea (HP:0002789)1.71351484
178Purpura (HP:0000979)1.70238528
179Acute necrotizing encephalopathy (HP:0006965)1.69779625
180Emphysema (HP:0002097)1.69556230
181Male pseudohermaphroditism (HP:0000037)1.69469215
182Type 1 muscle fiber predominance (HP:0003803)1.69042261
183Postaxial foot polydactyly (HP:0001830)1.68447514
184Abnormality of the labia minora (HP:0012880)1.68033816
185Keratoconus (HP:0000563)1.68006394
186Increased corneal curvature (HP:0100692)1.68006394
187Neoplasm of the rectum (HP:0100743)1.66537324
188Radial bowing (HP:0002986)1.66099839
189Abnormality of vitamin B metabolism (HP:0004340)1.66006815
190Onycholysis (HP:0001806)1.65978148
191Long toe (HP:0010511)1.64564955
192Toxemia of pregnancy (HP:0100603)1.64521905
193Mesangial abnormality (HP:0001966)1.63795749
194Rhabdomyolysis (HP:0003201)1.62914308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.53507031
2ERN13.10706164
3TTN3.07191997
4WNK32.86701294
5CAMKK22.86535697
6ADRBK22.69510349
7FRK2.65209796
8GRK12.61602672
9MAP2K32.52938161
10MARK12.49710364
11BMPR1B2.48083572
12NUAK12.36346677
13TRIB32.28413359
14SIK12.27461111
15BCKDK2.24677624
16MAPK132.23679775
17FLT32.18318768
18INSRR2.02962798
19ZAK2.02946096
20PKN22.00285755
21MAP4K12.00150298
22WNK41.93779056
23STK101.90860095
24PINK11.86239913
25TXK1.85529554
26KIT1.84311735
27MYLK1.83874701
28DMPK1.78981049
29LRRK21.78377145
30TRIM281.76303410
31MAP2K71.73556067
32TYK21.72813674
33EPHB11.66465911
34EEF2K1.64903085
35RPS6KB21.64137416
36PNCK1.62561291
37MAPK151.61804432
38MAP3K41.58235640
39CASK1.57905161
40BTK1.50626659
41PAK31.46168064
42JAK31.46162749
43DYRK21.44931492
44PASK1.44738183
45SIK31.40941863
46BCR1.40184877
47TEC1.37974389
48TGFBR11.37429639
49CAMK1D1.33009132
50ITK1.31096685
51STK391.31068952
52CDK191.28366105
53PRKD31.28079701
54BRSK21.27720773
55CDK91.25450751
56SRPK11.25124459
57PIK3CA1.24119521
58CLK11.23767333
59ZAP701.21915876
60MST41.21882168
61FGFR41.19980128
62NLK1.19889527
63TGFBR21.17829881
64LIMK11.17697472
65TIE11.15232741
66OBSCN1.12852189
67ACVR1B1.12618200
68CDC42BPA1.10248287
69LMTK21.06866380
70MAP4K21.04568289
71PTK61.03078179
72CAMKK11.00694876
73OXSR11.00644859
74DAPK21.00556511
75TRPM70.98102923
76EPHA30.97869647
77CSF1R0.97746165
78MAP3K70.96852099
79FER0.96481877
80NEK90.94106816
81MAP2K60.92235084
82BRD40.89507825
83EIF2AK30.89295487
84CDK60.88617111
85EIF2AK10.88120593
86CHUK0.86155581
87IKBKE0.85107114
88ADRBK10.84939029
89EPHA40.84684744
90ILK0.83473829
91TLK10.82007342
92MAPKAPK30.80836727
93MAP3K30.80718577
94PRKCQ0.78507071
95RPS6KA40.77614940
96TBK10.77318355
97STK40.76843009
98MATK0.76283463
99CSNK1G20.76261213
100CDK40.75806009
101CSNK1G30.75716991
102IKBKB0.74225130
103CDK80.73615861
104MAP3K60.73317291
105GRK70.72989035
106RPS6KA50.72929700
107NTRK30.72486846
108ERBB30.71965584
109MAP3K130.71530065
110MAPKAPK50.70981334
111PRKCG0.70319471
112STK240.69151072
113JAK10.68195814
114TNIK0.68149958
115STK30.68045007
116FGFR20.66522917
117PAK20.66051014
118PAK40.65638208
119VRK10.65603634
120PRKCE0.65230171
121EPHB20.64675260
122PTK2B0.64009036
123PHKG10.63359640
124PHKG20.63359640
125MKNK10.63149168
126CAMK10.62719560
127MAPK110.61788583
128LCK0.61296511
129IRAK40.61000803
130CAMK40.60527135
131PRKAA20.59820581
132FGFR30.58820072
133RPS6KA60.57478430
134PRKCI0.57413699
135TSSK60.56541371
136CSNK1A1L0.56344424
137CAMK1G0.56121653
138CSNK1G10.55590287
139TAOK20.53222798
140RET0.52833667
141IRAK30.52455960
142MINK10.52120890
143PRKCZ0.51579824
144MARK30.50820181
145CSK0.49036429
146PDGFRB0.47467972
147TNK20.47305831
148MAP3K80.46246700
149MARK20.45456574
150PIK3CG0.43983287
151MAP3K140.43407768
152DYRK30.42690475
153MET0.41818688
154RPS6KL10.41421263
155RPS6KC10.41421263
156TESK10.41080776
157VRK20.37284630
158ABL10.36511421
159CSNK1A10.36098287
160STK160.35679457
161CAMK2A0.35245113
162IGF1R0.35163038
163PRKACA0.33589906
164SYK0.33123477
165CCNB10.32051554
166ATM0.30548545
167PIM20.29943754
168PRKD20.28962196
169ATR0.26921891
170PRKCA0.26677730
171MAP3K110.25588240
172DYRK1A0.25134966
173MUSK0.24889956

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.29935432
2Fatty acid elongation_Homo sapiens_hsa000622.82986365
3Propanoate metabolism_Homo sapiens_hsa006402.80696629
4Phototransduction_Homo sapiens_hsa047442.76383955
5Protein export_Homo sapiens_hsa030602.67673404
6Butanoate metabolism_Homo sapiens_hsa006502.62700068
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.62671584
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.51353499
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.33882658
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.24467269
11Fatty acid metabolism_Homo sapiens_hsa012122.21891334
12Oxidative phosphorylation_Homo sapiens_hsa001902.19296668
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11395901
14Linoleic acid metabolism_Homo sapiens_hsa005912.10525772
15Fatty acid degradation_Homo sapiens_hsa000712.10521269
16Selenocompound metabolism_Homo sapiens_hsa004502.03763012
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.00992011
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.96389910
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.87292875
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83520917
21B cell receptor signaling pathway_Homo sapiens_hsa046621.78829898
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78275462
23Parkinsons disease_Homo sapiens_hsa050121.69380847
24RNA polymerase_Homo sapiens_hsa030201.67236104
25Fanconi anemia pathway_Homo sapiens_hsa034601.65022676
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62036475
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.53250976
28Tryptophan metabolism_Homo sapiens_hsa003801.52565412
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.52440026
30Primary immunodeficiency_Homo sapiens_hsa053401.52291272
31Nicotine addiction_Homo sapiens_hsa050331.51786946
32Ether lipid metabolism_Homo sapiens_hsa005651.50553949
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.50059668
34Platelet activation_Homo sapiens_hsa046111.47305325
35Notch signaling pathway_Homo sapiens_hsa043301.43433371
36Collecting duct acid secretion_Homo sapiens_hsa049661.43154446
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.42186225
38Focal adhesion_Homo sapiens_hsa045101.40113577
39Basal transcription factors_Homo sapiens_hsa030221.37453113
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.37445952
41One carbon pool by folate_Homo sapiens_hsa006701.33814261
42Huntingtons disease_Homo sapiens_hsa050161.30127405
43Regulation of autophagy_Homo sapiens_hsa041401.28128256
44Insulin resistance_Homo sapiens_hsa049311.27303358
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25919064
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24879964
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24335294
48Chronic myeloid leukemia_Homo sapiens_hsa052201.23683089
49Herpes simplex infection_Homo sapiens_hsa051681.23503750
50Toxoplasmosis_Homo sapiens_hsa051451.23394161
51Nitrogen metabolism_Homo sapiens_hsa009101.22874917
52Carbon metabolism_Homo sapiens_hsa012001.20290758
53Leishmaniasis_Homo sapiens_hsa051401.17376154
54Small cell lung cancer_Homo sapiens_hsa052221.16906529
55Dilated cardiomyopathy_Homo sapiens_hsa054141.16705789
56Caffeine metabolism_Homo sapiens_hsa002321.15499748
57Lysine degradation_Homo sapiens_hsa003101.11207009
58ECM-receptor interaction_Homo sapiens_hsa045121.08792481
59PPAR signaling pathway_Homo sapiens_hsa033201.07997566
60Adipocytokine signaling pathway_Homo sapiens_hsa049201.07945717
61Shigellosis_Homo sapiens_hsa051311.07070381
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06508214
63Chemical carcinogenesis_Homo sapiens_hsa052041.06005886
64RNA degradation_Homo sapiens_hsa030181.05213367
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04556258
66Osteoclast differentiation_Homo sapiens_hsa043801.04436356
67Measles_Homo sapiens_hsa051621.03848461
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02434214
69Olfactory transduction_Homo sapiens_hsa047401.01819800
70Asthma_Homo sapiens_hsa053101.00902775
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00520168
72Taste transduction_Homo sapiens_hsa047421.00467963
73Peroxisome_Homo sapiens_hsa041460.99110878
74Base excision repair_Homo sapiens_hsa034100.98973439
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98429016
76Sulfur relay system_Homo sapiens_hsa041220.95951844
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.95672383
78Viral myocarditis_Homo sapiens_hsa054160.95604354
79T cell receptor signaling pathway_Homo sapiens_hsa046600.95148671
80HTLV-I infection_Homo sapiens_hsa051660.95005319
81Type I diabetes mellitus_Homo sapiens_hsa049400.94728812
82Thyroid cancer_Homo sapiens_hsa052160.94711991
83Alzheimers disease_Homo sapiens_hsa050100.93976465
84N-Glycan biosynthesis_Homo sapiens_hsa005100.93675360
85Proteoglycans in cancer_Homo sapiens_hsa052050.93145472
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91455956
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89953550
88Fatty acid biosynthesis_Homo sapiens_hsa000610.89651320
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.88924335
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88683487
91Folate biosynthesis_Homo sapiens_hsa007900.87454340
92DNA replication_Homo sapiens_hsa030300.87297920
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85307264
94Arachidonic acid metabolism_Homo sapiens_hsa005900.84450373
95Cell cycle_Homo sapiens_hsa041100.83269285
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82839870
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82488722
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.82402362
99Antigen processing and presentation_Homo sapiens_hsa046120.82032570
100Steroid biosynthesis_Homo sapiens_hsa001000.81814604
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81790598
102Sulfur metabolism_Homo sapiens_hsa009200.81189460
103Prolactin signaling pathway_Homo sapiens_hsa049170.80153242
104Acute myeloid leukemia_Homo sapiens_hsa052210.80145374
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79599576
106Mismatch repair_Homo sapiens_hsa034300.76742833
107Graft-versus-host disease_Homo sapiens_hsa053320.76706550
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.75855563
109Pancreatic cancer_Homo sapiens_hsa052120.75696557
110Allograft rejection_Homo sapiens_hsa053300.75376144
111Pyruvate metabolism_Homo sapiens_hsa006200.74622242
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74560849
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74320663
114Other glycan degradation_Homo sapiens_hsa005110.73926273
115Metabolic pathways_Homo sapiens_hsa011000.72166287
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72153009
117Hematopoietic cell lineage_Homo sapiens_hsa046400.72107959
118Pentose phosphate pathway_Homo sapiens_hsa000300.71948180
119Ribosome_Homo sapiens_hsa030100.70349237
120Circadian rhythm_Homo sapiens_hsa047100.70215497
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69721032
122Homologous recombination_Homo sapiens_hsa034400.69416556
123Hepatitis B_Homo sapiens_hsa051610.68885573
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68878463
125Retinol metabolism_Homo sapiens_hsa008300.68435616
126Insulin secretion_Homo sapiens_hsa049110.68427150
127AMPK signaling pathway_Homo sapiens_hsa041520.67442706
128Autoimmune thyroid disease_Homo sapiens_hsa053200.66229448
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65733182
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65118105
131Pyrimidine metabolism_Homo sapiens_hsa002400.64803355
132Insulin signaling pathway_Homo sapiens_hsa049100.64789846
133Influenza A_Homo sapiens_hsa051640.64292519
134Cocaine addiction_Homo sapiens_hsa050300.64057798
135Morphine addiction_Homo sapiens_hsa050320.63593688
136Legionellosis_Homo sapiens_hsa051340.62783181
137Drug metabolism - other enzymes_Homo sapiens_hsa009830.62573570
138ABC transporters_Homo sapiens_hsa020100.62429441
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.62367695
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62020720
141GABAergic synapse_Homo sapiens_hsa047270.61521266
142Ovarian steroidogenesis_Homo sapiens_hsa049130.61334386
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61311654
144Circadian entrainment_Homo sapiens_hsa047130.61290036
145Apoptosis_Homo sapiens_hsa042100.60214373
146Rheumatoid arthritis_Homo sapiens_hsa053230.59609279
147Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58617098
148Glycerolipid metabolism_Homo sapiens_hsa005610.58057689
149Lysosome_Homo sapiens_hsa041420.57687975
150beta-Alanine metabolism_Homo sapiens_hsa004100.56423521
151Calcium signaling pathway_Homo sapiens_hsa040200.56012221
152Biosynthesis of amino acids_Homo sapiens_hsa012300.55772269
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.55658064
154Protein digestion and absorption_Homo sapiens_hsa049740.55027658
155TNF signaling pathway_Homo sapiens_hsa046680.54633858
156Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54429217
157Basal cell carcinoma_Homo sapiens_hsa052170.54125193
158Pathways in cancer_Homo sapiens_hsa052000.53551995
159Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52357196
160Cardiac muscle contraction_Homo sapiens_hsa042600.52175124
161Histidine metabolism_Homo sapiens_hsa003400.51922726
162Hepatitis C_Homo sapiens_hsa051600.51849846
163Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51362182
164Purine metabolism_Homo sapiens_hsa002300.51229434
165Malaria_Homo sapiens_hsa051440.49462937
166Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48650806
167MicroRNAs in cancer_Homo sapiens_hsa052060.48535755
168NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48432653
169Viral carcinogenesis_Homo sapiens_hsa052030.47092017
170Amoebiasis_Homo sapiens_hsa051460.46457418
171Pancreatic secretion_Homo sapiens_hsa049720.45985720
172Amphetamine addiction_Homo sapiens_hsa050310.45946578
173Non-homologous end-joining_Homo sapiens_hsa034500.44172414
174Vitamin digestion and absorption_Homo sapiens_hsa049770.41960344
175Serotonergic synapse_Homo sapiens_hsa047260.41931285
176Glycerophospholipid metabolism_Homo sapiens_hsa005640.41850623
177Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36967766
178Salivary secretion_Homo sapiens_hsa049700.36417704

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