TRIM69

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.93552161
2epithelial cilium movement (GO:0003351)9.67720705
3spermatid development (GO:0007286)9.40516583
4motile cilium assembly (GO:0044458)9.35269929
5reproduction (GO:0000003)9.33180224
6male meiosis (GO:0007140)8.89573546
7cilium movement (GO:0003341)8.37132528
8positive regulation of cell size (GO:0045793)8.35129191
9regulation of cilium movement (GO:0003352)8.31092504
10arginine catabolic process (GO:0006527)8.28936640
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.23952879
12synaptonemal complex organization (GO:0070193)8.23322697
13synaptonemal complex assembly (GO:0007130)7.96015361
14diaphragm development (GO:0060539)7.78243077
15single fertilization (GO:0007338)7.46036343
16negative regulation of neurotransmitter transport (GO:0051589)7.36315057
17negative regulation of calcium ion transport into cytosol (GO:0010523)7.21311122
18skeletal muscle organ development (GO:0060538)7.05170859
19sperm capacitation (GO:0048240)7.03279460
20arginine metabolic process (GO:0006525)6.62732332
21negative regulation of inclusion body assembly (GO:0090084)6.48556523
22negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)6.42721063
23fertilization (GO:0009566)6.41236150
24spermatogenesis (GO:0007283)6.26740190
25exogenous drug catabolic process (GO:0042738)6.25341388
26male gamete generation (GO:0048232)6.24455207
27DNA methylation involved in gamete generation (GO:0043046)6.22098322
28positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)6.19291327
29pyrimidine nucleoside salvage (GO:0043097)6.13810593
30pyrimidine-containing compound salvage (GO:0008655)6.13810593
31response to lipoprotein particle (GO:0055094)5.93813993
32negative regulation of peptidyl-threonine phosphorylation (GO:0010801)5.91483027
33male meiosis I (GO:0007141)5.83268732
34gamete generation (GO:0007276)5.73274329
35positive regulation of guanylate cyclase activity (GO:0031284)5.61488150
36chromosome organization involved in meiosis (GO:0070192)5.60990131
37organic cation transport (GO:0015695)5.59107109
38negative regulation of vascular permeability (GO:0043116)5.58170802
39ventricular system development (GO:0021591)5.54695797
40regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.53701150
41microtubule depolymerization (GO:0007019)5.49106936
42cellular process involved in reproduction in multicellular organism (GO:0022412)5.39125186
43germ cell development (GO:0007281)5.37267586
44pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)5.24263781
45UMP biosynthetic process (GO:0006222)5.24263781
46pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)5.24263781
47UMP metabolic process (GO:0046049)5.24263781
48regulation of inclusion body assembly (GO:0090083)5.23912670
49negative regulation of potassium ion transport (GO:0043267)5.22747011
50regulation of guanylate cyclase activity (GO:0031282)5.17008981
51regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)5.16984475
52meiotic nuclear division (GO:0007126)5.16180044
53regulation of neurotransmitter uptake (GO:0051580)5.05885308
54drug catabolic process (GO:0042737)4.98365310
55cellular protein complex localization (GO:0034629)4.98049534
56positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.94628300
57cell recognition (GO:0008037)4.92722892
58seminiferous tubule development (GO:0072520)4.92023301
59calcium ion-dependent exocytosis (GO:0017156)4.88802822
60microtubule severing (GO:0051013)4.86273138
61regulation of microtubule-based movement (GO:0060632)4.84699789
62meiosis I (GO:0007127)4.71198236
63nerve growth factor signaling pathway (GO:0038180)4.62265614
64multicellular organismal reproductive process (GO:0048609)4.49956926
65regulation of nuclear cell cycle DNA replication (GO:0033262)4.44260423
663-UTR-mediated mRNA stabilization (GO:0070935)4.43314347
67meiotic cell cycle (GO:0051321)4.33963831
68left/right pattern formation (GO:0060972)4.27741350
69activation of MAPKKK activity (GO:0000185)4.24456255
70negative regulation of T cell receptor signaling pathway (GO:0050860)4.17507240
71spermatid nucleus differentiation (GO:0007289)4.16015573
72protein localization to cilium (GO:0061512)4.14355536
73nucleotide salvage (GO:0043173)4.13876098
74negative regulation of macrophage differentiation (GO:0045650)4.12775552
75monoubiquitinated protein deubiquitination (GO:0035520)4.02049086
76nitric oxide biosynthetic process (GO:0006809)4.00919511
77pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)4.00308870
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.98282522
79positive regulation of sodium ion transmembrane transport (GO:1902307)3.92574252
80histone H3-K4 methylation (GO:0051568)3.92036324
81positive regulation of signal transduction by p53 class mediator (GO:1901798)3.90376163
82protein heterotrimerization (GO:0070208)3.88987152
83protein polyglutamylation (GO:0018095)3.88383796
84nucleoside salvage (GO:0043174)3.86746680
85negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.84675011
86genitalia morphogenesis (GO:0035112)3.83496899
87chromosome condensation (GO:0030261)3.79419290
88negative regulation of granulocyte differentiation (GO:0030853)3.77411817
89nitric oxide mediated signal transduction (GO:0007263)3.76862494
90glycerol ether metabolic process (GO:0006662)3.71695228
91chaperone-mediated protein complex assembly (GO:0051131)3.71499570
92pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.70651678
93gene silencing by RNA (GO:0031047)3.69374149
94DNA packaging (GO:0006323)3.65565978
95multicellular organismal development (GO:0007275)3.64673770
96negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.63356347
97DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.59214119
98neurotransmitter biosynthetic process (GO:0042136)3.57780560
99positive regulation of receptor biosynthetic process (GO:0010870)3.56239891
100regulation of mRNA catabolic process (GO:0061013)3.54849761
101synapsis (GO:0007129)3.49978741
102cellular response to nerve growth factor stimulus (GO:1990090)3.48897792
103response to nerve growth factor (GO:1990089)3.48897792
104negative regulation of protein kinase B signaling (GO:0051898)3.48688546
105positive regulation of catecholamine secretion (GO:0033605)3.47870859
106intraciliary transport (GO:0042073)3.42622941
107ether metabolic process (GO:0018904)3.42267666
108regulation of protein deacetylation (GO:0090311)3.42200166
109positive regulation of cGMP biosynthetic process (GO:0030828)3.40848362
110positive regulation of mRNA catabolic process (GO:0061014)3.38882926
111regulation of cilium assembly (GO:1902017)3.37239893
112regulation of synaptic vesicle transport (GO:1902803)3.33708572
113meiotic cell cycle process (GO:1903046)3.32844898
114amino-acid betaine transport (GO:0015838)3.32548811
115carnitine transport (GO:0015879)3.32548811
116carnitine transmembrane transport (GO:1902603)3.28637420
117regulation of cholesterol biosynthetic process (GO:0045540)3.28634294
118regulation of spindle checkpoint (GO:0090231)3.28348486
119negative regulation of potassium ion transmembrane transport (GO:1901380)3.26542335
120lateral sprouting from an epithelium (GO:0060601)3.24913364
121regulation of cGMP biosynthetic process (GO:0030826)3.24368875
122inactivation of MAPK activity (GO:0000188)3.23193002
123positive regulation of histone acetylation (GO:0035066)3.21364830
124adenine nucleotide transport (GO:0051503)3.20921009
125negative regulation of organelle assembly (GO:1902116)3.17029337
126DNA damage response, signal transduction resulting in transcription (GO:0042772)3.14875158
127microtubule-based movement (GO:0007018)3.13828635
128negative regulation of neurotransmitter secretion (GO:0046929)3.13414958
129opioid receptor signaling pathway (GO:0038003)3.13275727
130protein K11-linked deubiquitination (GO:0035871)3.11918434
131axoneme assembly (GO:0035082)3.10095552
132regulation of stem cell maintenance (GO:2000036)3.03624958
133phagosome maturation (GO:0090382)3.01866551
134nuclear pore complex assembly (GO:0051292)3.01782659
135Rap protein signal transduction (GO:0032486)3.00507177
136hypotonic response (GO:0006971)3.00125791
137cilium organization (GO:0044782)2.99968242
138negative regulation of alcohol biosynthetic process (GO:1902931)2.98623036
139lactate metabolic process (GO:0006089)2.97760734
140protein refolding (GO:0042026)2.97135711
141myoblast fusion (GO:0007520)2.96957370
142regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.94683711
143regulation of centriole replication (GO:0046599)2.94516801
144mitotic sister chromatid cohesion (GO:0007064)2.91358989
145positive regulation of peptidyl-lysine acetylation (GO:2000758)2.90643491
146positive regulation of protein acetylation (GO:1901985)2.90643491
147alditol metabolic process (GO:0019400)2.90070390
148chromatin silencing (GO:0006342)2.89481243
149positive regulation of cGMP metabolic process (GO:0030825)2.86391807
150cilium assembly (GO:0042384)2.83364553
151nucleus organization (GO:0006997)2.83206535
152polyol catabolic process (GO:0046174)2.83055308
153cilium morphogenesis (GO:0060271)2.81550220
154cellular component assembly involved in morphogenesis (GO:0010927)2.81092457
155nucleoside diphosphate phosphorylation (GO:0006165)2.80711562
156peptidyl-glutamic acid modification (GO:0018200)2.79407738
157regulation of oxidative phosphorylation (GO:0002082)2.78894978
158glycolytic process (GO:0006096)2.77929580
159respiratory chain complex IV assembly (GO:0008535)2.77147877
160peptidyl-cysteine modification (GO:0018198)2.76613227
161regulation of voltage-gated calcium channel activity (GO:1901385)2.76207662
162interferon-gamma secretion (GO:0072643)2.76058190
163CTP biosynthetic process (GO:0006241)2.73323392
164CTP metabolic process (GO:0046036)2.73323392
165regulation of meiosis I (GO:0060631)2.72020242
166microtubule polymerization or depolymerization (GO:0031109)2.71020851
167regulation of cGMP metabolic process (GO:0030823)2.70795079
168determination of left/right symmetry (GO:0007368)2.70767764
169gene silencing (GO:0016458)2.70584567
170sequestering of actin monomers (GO:0042989)2.70024774
171mRNA stabilization (GO:0048255)2.69774235
172RNA stabilization (GO:0043489)2.69774235
173oogenesis (GO:0048477)2.69540068
174positive regulation of circadian rhythm (GO:0042753)2.69257477
175single strand break repair (GO:0000012)2.69110762
176platelet-derived growth factor receptor signaling pathway (GO:0048008)2.69066836
177regulation of T cell receptor signaling pathway (GO:0050856)2.68813831
178cellular response to toxic substance (GO:0097237)2.68027426
179long-term synaptic potentiation (GO:0060291)2.67236154
180sexual reproduction (GO:0019953)2.66441343
181centriole assembly (GO:0098534)2.59092725
182regulation of protein polyubiquitination (GO:1902914)2.55971946
183glycerol metabolic process (GO:0006071)2.49336167
184centriole replication (GO:0007099)2.45907665
185GTP biosynthetic process (GO:0006183)2.42408243
186cilium or flagellum-dependent cell motility (GO:0001539)13.5937641
187fusion of sperm to egg plasma membrane (GO:0007342)13.2280715
188sperm motility (GO:0030317)12.8931927
189acrosome assembly (GO:0001675)11.8206762
190sperm-egg recognition (GO:0035036)11.5388381
191multicellular organism reproduction (GO:0032504)11.2367704
192acrosome reaction (GO:0007340)11.0225376
193cell wall macromolecule metabolic process (GO:0044036)10.7281839
194cell wall macromolecule catabolic process (GO:0016998)10.7281839
195axonemal dynein complex assembly (GO:0070286)10.7023214
196binding of sperm to zona pellucida (GO:0007339)10.4799534
197cell-cell recognition (GO:0009988)10.3440841
198plasma membrane fusion (GO:0045026)10.0362435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.90101615
2EZH2_22144423_ChIP-Seq_EOC_Human4.87838494
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.94751688
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.73625678
5RUNX_20019798_ChIP-Seq_JUKART_Human2.54120195
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.41827200
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32888033
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26839692
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20684833
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.18439899
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13308810
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.10837990
13NR3C1_21868756_ChIP-Seq_MCF10A_Human2.07602547
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.02450556
15DROSHA_22980978_ChIP-Seq_HELA_Human2.02071319
16VDR_22108803_ChIP-Seq_LS180_Human2.01571632
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.0287342
18GATA1_22025678_ChIP-Seq_K562_Human1.99898305
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99664556
20ZNF274_21170338_ChIP-Seq_K562_Hela1.98273088
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94498298
22SCL_19346495_ChIP-Seq_HPC-7_Human1.91749711
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.87999512
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85736316
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.72353997
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.70668809
27KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70352449
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68524378
29FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64247610
30STAT1_17558387_ChIP-Seq_HELA_Human1.63680186
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62352689
32GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53944301
33RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52379831
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50287400
35GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49937772
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48786810
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48781565
38* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.48113533
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46168937
40CBP_20019798_ChIP-Seq_JUKART_Human1.46168937
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.45878750
42P53_22127205_ChIP-Seq_FIBROBLAST_Human1.45862062
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.45542889
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.45140057
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.39505879
46TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39229944
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.39026614
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38818932
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37234270
50KDM2B_26808549_Chip-Seq_REH_Human1.36779140
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36714425
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34959468
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31687427
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31144761
55MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31123191
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30775749
57TAF15_26573619_Chip-Seq_HEK293_Human1.30382649
58* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.30096702
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29202988
60LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28358522
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.27124321
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25299141
63FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24927782
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23850245
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.23646815
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22845725
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.22645281
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.22321638
69GATA3_21867929_ChIP-Seq_TH1_Mouse1.21354545
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20821356
71AHR_22903824_ChIP-Seq_MCF-7_Human1.20368081
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19464981
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18785323
74SMAD3_21741376_ChIP-Seq_ESCs_Human1.17309526
75GATA3_26560356_Chip-Seq_TH2_Human1.16527568
76P53_21459846_ChIP-Seq_SAOS-2_Human1.16439232
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.16294352
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15434934
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.15391200
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14737946
81GF1_26923725_Chip-Seq_HPCs_Mouse1.14162800
82RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13954842
83SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13500895
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11599150
85CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10703176
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.09732191
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.09226362
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08663125
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08663125
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07962746
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07368661
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06720946
93RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06575666
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06569050
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06351750
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05913497
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.04667784
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04151435
99OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02892482
100* OCT4_18555785_Chip-Seq_ESCs_Mouse1.02889467
101STAT3_23295773_ChIP-Seq_U87_Human1.02769325
102REST_21632747_ChIP-Seq_MESCs_Mouse1.02730656
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02628741
104SPI1_26923725_Chip-Seq_HPCs_Mouse1.02604185
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02390436
106CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01782994
107FUS_26573619_Chip-Seq_HEK293_Human1.01678481
108P53_22387025_ChIP-Seq_ESCs_Mouse1.00395119
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00058879
110SMC4_20622854_ChIP-Seq_HELA_Human1.00038561
111CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99901970
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99658477
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99133349
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.99093314
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98935908
116SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98792806
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98546325
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98274155
119GATA3_27048872_Chip-Seq_THYMUS_Human0.97934044
120AR_25329375_ChIP-Seq_VCAP_Human0.97878935
121TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.97856519
122KLF4_18555785_Chip-Seq_ESCs_Mouse0.97533437
123ESET_19884257_ChIP-Seq_ESCs_Mouse0.97007108
124OCT1_27270436_Chip-Seq_PROSTATE_Human0.96925098
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96427186
126ERG_20517297_ChIP-Seq_VCAP_Human0.96260494
127SMAD4_21799915_ChIP-Seq_A2780_Human0.95991765
128P300_18555785_Chip-Seq_ESCs_Mouse0.95317073
129RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95229098
130RARA_24833708_ChIP-Seq_LIVER_Mouse0.94977395
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94629418
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94543240
133EZH2_27304074_Chip-Seq_ESCs_Mouse0.94430851
134TCF4_22108803_ChIP-Seq_LS180_Human0.94375617
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94288725
136SMRT_27268052_Chip-Seq_Bcells_Human0.94003045
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.93830540
138RNF2_27304074_Chip-Seq_NSC_Mouse0.93209324
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93076162
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93037443
141CMYC_18555785_Chip-Seq_ESCs_Mouse0.92965221
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92589863
143* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92150725
144LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91124924
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90795036
146SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90325919
147STAT3_18555785_Chip-Seq_ESCs_Mouse0.90201960
148MYC_27129775_Chip-Seq_CORNEA_Mouse0.90192884
149SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90096611
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89988380
151TP53_16413492_ChIP-PET_HCT116_Human0.89722687
152TCF4_23295773_ChIP-Seq_U87_Human0.89628691
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89232928
154SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88004150
155SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87239425
156RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87148836
157LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87044573
158AR_21572438_ChIP-Seq_LNCaP_Human0.86625414
159RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86523624
160E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86356508
161PU1_27457419_Chip-Seq_LIVER_Mouse0.86246591
162GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86170160
163YY1_22570637_ChIP-Seq_MALME-3M_Human0.85806864
164FLI1_21867929_ChIP-Seq_CD8_Mouse0.85520933
165EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85402241
166NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85067134
167GF1B_26923725_Chip-Seq_HPCs_Mouse0.84910708
168TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83986144
169SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83768527
170NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83680830
171AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82308424
172SMAD4_21741376_ChIP-Seq_ESCs_Human0.81229981
173TAF2_19829295_ChIP-Seq_ESCs_Human0.80232747
174POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79866327
175AR_19668381_ChIP-Seq_PC3_Human0.79636187
176CBX2_22325352_ChIP-Seq_293T-Rex_Human0.79536502
177GATA1_19941827_ChIP-Seq_MEL_Mouse0.78903176
178EZH2_27294783_Chip-Seq_ESCs_Mouse0.78607595
179GBX2_23144817_ChIP-Seq_PC3_Human0.77726633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.29590554
2MP0003698_abnormal_male_reproductive5.97025302
3MP0001929_abnormal_gametogenesis5.53753002
4MP0008877_abnormal_DNA_methylation4.98529127
5MP0004043_abnormal_pH_regulation4.59810550
6MP0005645_abnormal_hypothalamus_physiol4.44151045
7MP0005167_abnormal_blood-brain_barrier4.41608215
8MP0004858_abnormal_nervous_system3.99172328
9MP0002210_abnormal_sex_determination3.72531306
10MP0010368_abnormal_lymphatic_system3.32537487
11MP0002161_abnormal_fertility/fecundity3.22420182
12MP0001145_abnormal_male_reproductive3.11530949
13MP0002653_abnormal_ependyma_morphology3.09794300
14MP0000653_abnormal_sex_gland2.71163813
15MP0004084_abnormal_cardiac_muscle2.47395408
16MP0001501_abnormal_sleep_pattern2.33841200
17MP0005623_abnormal_meninges_morphology2.32995431
18MP0009053_abnormal_anal_canal2.06647634
19MP0005670_abnormal_white_adipose2.00344332
20MP0005410_abnormal_fertilization15.7707633
21MP0003283_abnormal_digestive_organ1.97150889
22MP0008872_abnormal_physiological_respon1.84758194
23MP0002160_abnormal_reproductive_system1.75424404
24MP0003646_muscle_fatigue1.71390845
25MP0002009_preneoplasia1.64602027
26MP0001919_abnormal_reproductive_system1.63449827
27MP0003724_increased_susceptibility_to1.61530332
28MP0004484_altered_response_of1.58785184
29MP0008057_abnormal_DNA_replication1.56713610
30MP0001664_abnormal_digestion1.54601237
31MP0002282_abnormal_trachea_morphology1.45944058
32MP0009764_decreased_sensitivity_to1.36779893
33MP0005671_abnormal_response_to1.35980779
34MP0008775_abnormal_heart_ventricle1.30989651
35MP0000467_abnormal_esophagus_morphology1.29766728
36MP0001440_abnormal_grooming_behavior1.27465848
37MP0008058_abnormal_DNA_repair1.25246687
38MP0009745_abnormal_behavioral_response1.24413843
39MP0004883_abnormal_blood_vessel1.20626301
40MP0003718_maternal_effect1.18679195
41MP0004233_abnormal_muscle_weight1.14003118
42MP0009046_muscle_twitch1.12830312
43MP0005387_immune_system_phenotype1.11269103
44MP0001790_abnormal_immune_system1.11269103
45MP0000470_abnormal_stomach_morphology1.06798155
46MP0002064_seizures1.05382092
47MP0003763_abnormal_thymus_physiology1.04954567
48MP0005647_abnormal_sex_gland1.03452853
49MP0003075_altered_response_to0.99818234
50MP0010094_abnormal_chromosome_stability0.96344272
51MP0001765_abnormal_ion_homeostasis0.96110438
52MP0005389_reproductive_system_phenotype0.93415226
53MP0006138_congestive_heart_failure0.92309143
54MP0002127_abnormal_cardiovascular_syste0.92038579
55MP0002272_abnormal_nervous_system0.91400236
56MP0002063_abnormal_learning/memory/cond0.90925108
57MP0000733_abnormal_muscle_development0.89820010
58MP0002233_abnormal_nose_morphology0.89321346
59MP0005166_decreased_susceptibility_to0.88244203
60MP0001879_abnormal_lymphatic_vessel0.87522157
61MP0003303_peritoneal_inflammation0.82545442
62MP0001984_abnormal_olfaction0.82537971
63MP0001663_abnormal_digestive_system0.80479880
64MP0001970_abnormal_pain_threshold0.80472409
65MP0005423_abnormal_somatic_nervous0.80080081
66MP0004885_abnormal_endolymph0.78900388
67MP0005397_hematopoietic_system_phenotyp0.78850269
68MP0001545_abnormal_hematopoietic_system0.78850269
69MP0000569_abnormal_digit_pigmentation0.78817904
70MP0004130_abnormal_muscle_cell0.77386650
71MP0005076_abnormal_cell_differentiation0.77275827
72MP0000767_abnormal_smooth_muscle0.75765118
73MP0000955_abnormal_spinal_cord0.74684970
74MP0002572_abnormal_emotion/affect_behav0.72277280
75MP0003011_delayed_dark_adaptation0.71278930
76MP0000383_abnormal_hair_follicle0.70860386
77MP0008995_early_reproductive_senescence0.70591656
78MP0008007_abnormal_cellular_replicative0.70083487
79MP0009785_altered_susceptibility_to0.69533751
80MP0003635_abnormal_synaptic_transmissio0.68315815
81MP0010307_abnormal_tumor_latency0.66245943
82MP0004808_abnormal_hematopoietic_stem0.65250572
83MP0001800_abnormal_humoral_immune0.64340987
84MP0002109_abnormal_limb_morphology0.64162515
85MP0009278_abnormal_bone_marrow0.63228949
86MP0002723_abnormal_immune_serum0.62727426
87MP0005000_abnormal_immune_tolerance0.62498356
88MP0003115_abnormal_respiratory_system0.62487202
89MP0000631_abnormal_neuroendocrine_gland0.62267148
90MP0002166_altered_tumor_susceptibility0.61623518
91MP0001756_abnormal_urination0.60150280
92MP0002148_abnormal_hypersensitivity_rea0.59850842
93MP0005377_hearing/vestibular/ear_phenot0.58620991
94MP0003878_abnormal_ear_physiology0.58620991
95MP0003786_premature_aging0.58592279
96MP0005503_abnormal_tendon_morphology0.57868785
97MP0002452_abnormal_antigen_presenting0.57840829
98MP0002138_abnormal_hepatobiliary_system0.57322790
99MP0002420_abnormal_adaptive_immunity0.56965607
100MP0010329_abnormal_lipoprotein_level0.56638003
101MP0000230_abnormal_systemic_arterial0.56579284
102MP0008874_decreased_physiological_sensi0.55874159
103MP0001819_abnormal_immune_cell0.55612822
104MP0000358_abnormal_cell_content/0.53470648
105MP0001533_abnormal_skeleton_physiology0.53398388
106MP0003950_abnormal_plasma_membrane0.53094352
107MP0001845_abnormal_inflammatory_respons0.53043233
108MP0005332_abnormal_amino_acid0.51704265
109MP0002928_abnormal_bile_duct0.51209960
110MP0002277_abnormal_respiratory_mucosa0.51129606
111MP0003699_abnormal_female_reproductive0.50714077
112MP0005636_abnormal_mineral_homeostasis0.48754338
113MP0005025_abnormal_response_to0.48206087
114MP0001873_stomach_inflammation0.48081553
115MP0004134_abnormal_chest_morphology0.47970820
116MP0005197_abnormal_uvea_morphology0.47474854
117MP0004142_abnormal_muscle_tone0.46321502
118MP0003879_abnormal_hair_cell0.45913438
119MP0005666_abnormal_adipose_tissue0.45280817
120MP0001119_abnormal_female_reproductive0.44442519
121MP0005164_abnormal_response_to0.44202110
122MP0002067_abnormal_sensory_capabilities0.44108090
123MP0003111_abnormal_nucleus_morphology0.43605177
124MP0002557_abnormal_social/conspecific_i0.43365012
125MP0002113_abnormal_skeleton_development0.42564168
126MP0001293_anophthalmia0.42462991
127MP0002116_abnormal_craniofacial_bone0.40460480
128MP0005310_abnormal_salivary_gland0.39938080
129MP0001324_abnormal_eye_pigmentation0.39850547
130MP0002234_abnormal_pharynx_morphology0.39326608
131MP0004036_abnormal_muscle_relaxation0.38656371
132MP0002405_respiratory_system_inflammati0.36984913
133MP0009115_abnormal_fat_cell0.34166615
134MP0001764_abnormal_homeostasis0.33494911
135MP0001730_embryonic_growth_arrest0.33200914
136MP0004133_heterotaxia0.33041182
137MP0002269_muscular_atrophy0.32907012
138MP0008961_abnormal_basal_metabolism0.31725427
139MP0003045_fibrosis0.31240732
140MP0000313_abnormal_cell_death0.28627182
141MP0001348_abnormal_lacrimal_gland0.27578226
142MP0003329_amyloid_beta_deposits0.26939983
143MP0004019_abnormal_vitamin_homeostasis0.26877225
144MP0002971_abnormal_brown_adipose0.26209795
145MP0002108_abnormal_muscle_morphology0.25568505
146MP0005391_vision/eye_phenotype0.25261519
147MP0001661_extended_life_span0.24741237
148MP0002295_abnormal_pulmonary_circulatio0.24328502
149MP0002102_abnormal_ear_morphology0.24098887
150MP0005253_abnormal_eye_physiology0.23915792
151MP0001851_eye_inflammation0.23503091
152MP0001835_abnormal_antigen_presentation0.23037724
153MP0000685_abnormal_immune_system0.22310374
154MP0005275_abnormal_skin_tensile0.21366649
155MP0000751_myopathy0.20173574
156MP0002092_abnormal_eye_morphology0.20081163
157MP0003077_abnormal_cell_cycle0.19808411
158MP0002132_abnormal_respiratory_system0.19572283
159MP0001727_abnormal_embryo_implantation0.18210445
160MP0000534_abnormal_ureter_morphology0.18188791
161MP0003943_abnormal_hepatobiliary_system0.17695877
162MP0005551_abnormal_eye_electrophysiolog0.17409730
163MP0003633_abnormal_nervous_system0.16781266
164MP0006082_CNS_inflammation0.16657982
165MP0003631_nervous_system_phenotype0.14889019
166MP0002084_abnormal_developmental_patter0.14853051
167MP0003861_abnormal_nervous_system0.14468753
168MP0000604_amyloidosis0.14418363
169MP0008438_abnormal_cutaneous_collagen0.13970130
170MP0003936_abnormal_reproductive_system0.13922674
171MP0006036_abnormal_mitochondrial_physio0.13822220
172MP0005380_embryogenesis_phenotype0.12356206
173MP0001672_abnormal_embryogenesis/_devel0.12356206
174MP0002169_no_abnormal_phenotype0.12008186
175MP0002873_normal_phenotype0.11678267
176MP0000427_abnormal_hair_cycle0.11558964
177MP0003948_abnormal_gas_homeostasis0.11387389
178MP0004811_abnormal_neuron_physiology0.11197971
179MP0005375_adipose_tissue_phenotype0.11126388
180MP0000432_abnormal_head_morphology0.10597887
181MP0002168_other_aberrant_phenotype0.10372391

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.41153810
2Autoimmune thrombocytopenia (HP:0001973)9.01362470
3Abnormal respiratory motile cilium morphology (HP:0005938)8.73897640
4Abnormal respiratory epithelium morphology (HP:0012253)8.73897640
5Rhinitis (HP:0012384)7.99681160
6Lip pit (HP:0100267)7.55461540
7Abnormal ciliary motility (HP:0012262)7.47967884
8Chronic bronchitis (HP:0004469)7.27324109
9Sparse lateral eyebrow (HP:0005338)7.08720020
10Nasal polyposis (HP:0100582)6.67158228
11Anal stenosis (HP:0002025)6.47120065
12Infertility (HP:0000789)6.44331656
13Abnormality of the fingertips (HP:0001211)6.25239448
14Depressed nasal tip (HP:0000437)6.23031555
15Intestinal fistula (HP:0100819)5.59549649
16Abnormality of the nasal mucosa (HP:0000433)5.51558965
17Ureteral stenosis (HP:0000071)5.45998033
18Ureteral obstruction (HP:0006000)5.09250446
19Short 5th finger (HP:0009237)4.93295644
20Bronchitis (HP:0012387)4.71612328
21Bronchiectasis (HP:0002110)4.67854477
22Aplasia/Hypoplasia of the 5th finger (HP:0006262)4.62693284
23Nephronophthisis (HP:0000090)4.48212903
24Lower limb hyperreflexia (HP:0002395)4.26086625
25Popliteal pterygium (HP:0009756)3.97810589
26Male infertility (HP:0003251)3.87413073
27Increased CSF protein (HP:0002922)3.59237696
28Ectopic kidney (HP:0000086)3.54976541
29Urinary glycosaminoglycan excretion (HP:0003541)3.45132274
30Mucopolysacchariduria (HP:0008155)3.45132274
31Abnormality of the renal medulla (HP:0100957)3.41086056
32Recurrent otitis media (HP:0000403)3.39679213
33Recurrent sinusitis (HP:0011108)3.38616787
34Abnormal spermatogenesis (HP:0008669)3.30488439
35Atonic seizures (HP:0010819)3.28346880
36Abnormality of polysaccharide metabolism (HP:0011012)3.28208629
37Abnormality of glycosaminoglycan metabolism (HP:0004371)3.28208629
38Abnormality of mucopolysaccharide metabolism (HP:0011020)3.28208629
39Dysostosis multiplex (HP:0000943)3.26694299
40Preauricular pit (HP:0004467)3.26501584
41Periauricular skin pits (HP:0100277)3.26501584
42Posterior subcapsular cataract (HP:0007787)3.22890140
43Pheochromocytoma (HP:0002666)3.15734754
44Ectropion (HP:0000656)3.10198568
45Recurrent bronchitis (HP:0002837)3.01137807
46Abnormality of the lower motor neuron (HP:0002366)2.98334361
47Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.92659597
48Vertebral hypoplasia (HP:0008417)2.92659597
49Abnormality of the periventricular white matter (HP:0002518)2.88141242
50Gonadotropin excess (HP:0000837)2.84596670
51Tubulointerstitial nephritis (HP:0001970)2.82839549
52Neuroendocrine neoplasm (HP:0100634)2.80182085
53Tubular atrophy (HP:0000092)2.78447679
54Frequent falls (HP:0002359)2.75479386
55Pancreatic cysts (HP:0001737)2.74742257
56Molar tooth sign on MRI (HP:0002419)2.65316192
57Abnormality of midbrain morphology (HP:0002418)2.65316192
58Long palpebral fissure (HP:0000637)2.63079173
59Mask-like facies (HP:0000298)2.57111226
60Tubulointerstitial abnormality (HP:0001969)2.52099260
61Wide intermamillary distance (HP:0006610)2.43614435
62Medial flaring of the eyebrow (HP:0010747)2.42095042
63Amyotrophic lateral sclerosis (HP:0007354)2.40361345
64Azoospermia (HP:0000027)2.38738063
65Impulsivity (HP:0100710)2.36697474
66Hypoplasia of the capital femoral epiphysis (HP:0003090)2.36270932
67Fibular hypoplasia (HP:0003038)2.35434119
68Generalized aminoaciduria (HP:0002909)2.32273063
69Progressive neurologic deterioration (HP:0002344)2.29466107
70Absent eyebrow (HP:0002223)2.25850113
71Blue irides (HP:0000635)2.24977064
72Congenital sensorineural hearing impairment (HP:0008527)2.19637500
73Absence seizures (HP:0002121)2.18516175
74Confusion (HP:0001289)2.18282959
75Febrile seizures (HP:0002373)2.13960347
76Tinnitus (HP:0000360)2.12126547
77Large eyes (HP:0001090)2.11716803
78Tubulointerstitial fibrosis (HP:0005576)2.11033448
79J-shaped sella turcica (HP:0002680)2.09694030
80Self-mutilation (HP:0000742)2.09550493
81Preaxial foot polydactyly (HP:0001841)2.08371985
82Postaxial foot polydactyly (HP:0001830)2.08005556
83Fatigue (HP:0012378)2.06517463
84Natal tooth (HP:0000695)2.03101334
85Hypoplastic labia majora (HP:0000059)2.02559670
86Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.01495400
87Narrow palate (HP:0000189)2.00209315
88Uterine leiomyosarcoma (HP:0002891)2.00154668
89Leiomyosarcoma (HP:0100243)2.00154668
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6700977
91Dynein arm defect of respiratory motile cilia (HP:0012255)12.5479460
92Absent/shortened dynein arms (HP:0200106)12.5479460
93Non-midline cleft lip (HP:0100335)1.99800988
94Impaired proprioception (HP:0010831)1.99084259
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98826003
96Abnormality of alanine metabolism (HP:0010916)1.98826003
97Hyperalaninemia (HP:0003348)1.98826003
98Stomach cancer (HP:0012126)1.98546149
99Stage 5 chronic kidney disease (HP:0003774)1.97926358
100Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.97139477
101Absent epiphyses (HP:0010577)1.97139477
102Skin pits (HP:0100276)1.94611014
103Cerebral hemorrhage (HP:0001342)1.94555308
104Broad hallux (HP:0010055)1.94080273
105Congenital hepatic fibrosis (HP:0002612)1.93653234
106Absent frontal sinuses (HP:0002688)1.93403336
107Renal cortical cysts (HP:0000803)1.93386779
108Poor head control (HP:0002421)1.92833316
109Renal cell carcinoma (HP:0005584)1.92217026
110Abnormal drinking behavior (HP:0030082)1.91585446
111Polydipsia (HP:0001959)1.91585446
112Fibular aplasia (HP:0002990)1.90707887
113Transitional cell carcinoma of the bladder (HP:0006740)1.90573316
114Conical tooth (HP:0000698)1.90547431
115Concave nail (HP:0001598)1.89919357
116Microglossia (HP:0000171)1.89741990
117Dialeptic seizures (HP:0011146)1.89594840
118Polyuria (HP:0000103)1.89070185
119Absent eyelashes (HP:0000561)1.87331302
120Abnormality of the labia majora (HP:0012881)1.87019925
121Broad thumb (HP:0011304)1.86799918
122Short ribs (HP:0000773)1.85521315
123Abnormality of the renal cortex (HP:0011035)1.84373170
124Spastic tetraparesis (HP:0001285)1.84043933
125Abnormality of the distal phalanges of the toes (HP:0010182)1.81457091
126Congenital hip dislocation (HP:0001374)1.79524878
127Neonatal short-limb short stature (HP:0008921)1.78604348
128Abnormality of permanent molar morphology (HP:0011071)1.76233334
129Abnormality of the dental root (HP:0006486)1.76233334
130Taurodontia (HP:0000679)1.76233334
131Chronic sinusitis (HP:0011109)1.74453085
132Upper motor neuron abnormality (HP:0002127)1.74437501
133Abnormality of dentin (HP:0010299)1.73520042
134Bell-shaped thorax (HP:0001591)1.72942325
135Oculomotor apraxia (HP:0000657)1.72677236
136Flat face (HP:0012368)1.72378764
137Deformed sella turcica (HP:0002681)1.72313284
138Bladder neoplasm (HP:0009725)1.71425346
139Bladder carcinoma (HP:0002862)1.71425346
140Facial shape deformation (HP:0011334)1.70538119
141Potter facies (HP:0002009)1.70538119
142Renal dysplasia (HP:0000110)1.68852441
143Optic neuritis (HP:0100653)1.68284291
144Retrobulbar optic neuritis (HP:0100654)1.68284291
145Abnormal gallbladder physiology (HP:0012438)1.67561664
146Cholecystitis (HP:0001082)1.67561664
147Facial cleft (HP:0002006)1.67557223
148Coarctation of aorta (HP:0001680)1.67290796
149Abnormality of molar morphology (HP:0011070)1.65087036
150Abnormality of molar (HP:0011077)1.65087036
151Heterotopia (HP:0002282)1.63379213
152Anal atresia (HP:0002023)1.62789240
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.61367002
154Bile duct proliferation (HP:0001408)1.60529816
155Abnormal biliary tract physiology (HP:0012439)1.60529816
156Abnormality of renal excretion (HP:0011036)1.59372198
157Abnormality of the dental pulp (HP:0006479)1.58982132
158Degeneration of anterior horn cells (HP:0002398)1.56381072
159Abnormality of the anterior horn cell (HP:0006802)1.56381072
160Short thorax (HP:0010306)1.54984278
161Dyschromatopsia (HP:0007641)1.53985353
162Postaxial hand polydactyly (HP:0001162)1.51626201
163Median cleft lip (HP:0000161)1.49177462
164Supernumerary spleens (HP:0009799)1.47641581
165Aplasia/Hypoplasia of the fibula (HP:0006492)1.43028102
166Aplasia/Hypoplasia of the tongue (HP:0010295)1.42264200
167Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.40849749
168Pancreatic fibrosis (HP:0100732)1.38032147
169Cystic liver disease (HP:0006706)1.37466310
170Short femoral neck (HP:0100864)1.36590502
171Decreased central vision (HP:0007663)1.35142035
172Choroideremia (HP:0001139)1.34987683
173Nephropathy (HP:0000112)1.33782707
174Abnormal urine output (HP:0012590)1.27834135
175Hemorrhage of the eye (HP:0011885)1.26540607
176Abnormality of the sella turcica (HP:0002679)1.23958294
177Abnormality of ocular smooth pursuit (HP:0000617)1.23540603
178Broad distal phalanx of finger (HP:0009836)1.22696444
179Aplasia/Hypoplasia of the lens (HP:0008063)1.20130730
180Congenital primary aphakia (HP:0007707)1.19964058
181Conjunctival telangiectasia (HP:0000524)1.19678463
182Pachygyria (HP:0001302)1.18695284
183Gait imbalance (HP:0002141)1.17845761
184Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.17358606
185Cerebellar dysplasia (HP:0007033)1.16908832
186Abnormality of saccadic eye movements (HP:0000570)1.16028921
187Breast carcinoma (HP:0003002)1.15743491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.71059459
2PDK38.71059459
3STK248.06958958
4PDK25.68692535
5TESK15.36667701
6PRKD34.38662165
7MAP3K23.66905355
8ICK3.63068675
9MAP3K33.37359766
10JAK33.09976283
11PTK2B2.60189491
12WNK42.42322088
13STK392.33048685
14MAPKAPK32.29612877
15PNCK2.08550415
16ZAK2.04074361
17ILK1.93683152
18NEK21.90115855
19CAMK41.63867816
20CAMK11.61423412
21STK381.54385180
22CAMKK21.34842516
23FRK1.31189566
24DAPK21.28431087
25RPS6KA61.25760139
26TRPM71.19511857
27RPS6KC11.19317162
28RPS6KL11.19317162
29ACVR1B1.18573914
30DYRK1B1.13083974
31MAPK151.08873452
32MAPK131.05369496
33WNK11.02633763
34PDK10.98429898
35STK30.94966503
36TYRO30.91174191
37PASK0.81529922
38ADRBK20.80076167
39CCNB10.77496550
40TNK20.73983224
41DYRK30.73005877
42TXK0.72385097
43MINK10.71420802
44IRAK10.71127950
45TNIK0.68458765
46CDC70.67918673
47TTK0.65204562
48JAK10.65172679
49GRK10.62709972
50IRAK40.60453171
51WEE10.59351981
52RPS6KA20.58502485
53HCK0.55799745
54IKBKE0.53709246
55STK38L0.52505929
56CHEK20.52180520
57CAMK1D0.50387485
58ATR0.49807059
59PINK10.49754525
60KIT0.49463278
61CAMK1G0.49405047
62CHEK10.49344955
63SYK0.48309816
64SGK20.46713889
65ADRBK10.45708337
66PDPK10.45210927
67EEF2K0.42930872
68TESK20.42752809
69NEK90.42394105
70RIPK40.42299067
71MAPK120.41953215
72MAP4K10.40965767
73OBSCN0.39811993
74BLK0.39405337
75LMTK20.39010091
76NTRK30.38533860
77TAOK30.36502350
78ATM0.35758427
79RPS6KB20.33843542
80CDK90.33797818
81CDK120.33357077
82PAK10.33095450
83MAP2K60.32190924
84MTOR0.30440215
85MUSK0.29724439
86MAP3K110.28606470
87BMPR1B0.28454003
88ERBB30.28050836
89PLK40.27395788
90MARK10.24852508
91CAMK2A0.24826112
92NEK60.24672699
93GRK70.24564169
94BRSK20.23542704
95PAK20.23256844
96PRKCE0.23252008
97NTRK20.22995198
98SGK2230.22842046
99SGK4940.22842046
100CSNK1G30.22767211
101STK40.22712576
102PRKCG0.22141013
103ZAP700.21929800
104BCKDK0.21669515
105MAP4K20.21109483
106IRAK20.20919124
107CSNK1G20.20794773
108PLK10.20621719
109MAP3K100.20367615
110LYN0.19597706
111WNK30.19425218
112MAPK110.18940827
113PRKAA10.18782208
114RPS6KB10.18364740
115CSNK1A1L0.18168480
116EPHA30.17398110
117CAMKK10.17355684
118FER0.17274327
119PRKCA0.15560264
120PRKCQ0.15406667
121MELK0.14543396
122IKBKB0.14419937
123EIF2AK20.14288591
124PRKACA0.13830320
125PIK3CA0.13429788
126STK100.13423028
127PAK30.13232828
128MAPKAPK50.11744440
129PDGFRB0.11123573
130CASK0.10972690
131ITK0.10787760
132CSF1R0.09893674
133MARK20.09593733
134MARK30.08234022
135PRKCZ0.07210076
136TBK10.05837305
137CSNK2A10.05769656
138RPS6KA10.05431100
139CSK0.05185898
140EGFR0.04997793
141MAP3K40.04292462
142EPHB10.03526309
143CDK10.03517947
144CDK20.03179719
145MAP2K70.02906002
146BRSK10.02818656
147PIM10.02690324
148MAPK80.02649796
149GSK3B0.02398936
150PAK40.02091353
151RIPK10.01844748
152PRKACG0.01301686
153PRKG10.01179411
154BRAF0.01062301
155CSNK1D0.00540260
156PRKDC0.00209524
157INSR-0.0313295
158CDK6-0.0293296
159MAPK10-0.0286737
160MAPK1-0.0247897
161CDK15-0.0169014
162MST1R-0.0149037
163CDK4-0.0138218
164PRKCD-0.0128681
165CSNK2A2-0.0116985
166STK11-0.0085514
167PRKCB-0.0077809
168CDK3-0.0058911
169YES1-0.0044690
170PRKG2-0.0025865
171MAP3K5-0.0004016

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002204.91576484
2Vitamin B6 metabolism_Homo sapiens_hsa007504.50663904
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.29385312
4Pyruvate metabolism_Homo sapiens_hsa006203.96339735
5Fatty acid biosynthesis_Homo sapiens_hsa000613.72213884
6Propanoate metabolism_Homo sapiens_hsa006403.02194175
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.79399290
8Pentose phosphate pathway_Homo sapiens_hsa000302.79109526
9Glucagon signaling pathway_Homo sapiens_hsa049222.78773319
10Basal transcription factors_Homo sapiens_hsa030222.74500306
11Linoleic acid metabolism_Homo sapiens_hsa005912.68644838
12Phototransduction_Homo sapiens_hsa047442.63847803
13Dorso-ventral axis formation_Homo sapiens_hsa043202.51293245
14Selenocompound metabolism_Homo sapiens_hsa004502.39974880
15Fanconi anemia pathway_Homo sapiens_hsa034602.20813424
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19312598
17Circadian entrainment_Homo sapiens_hsa047132.09340637
18Intestinal immune network for IgA production_Homo sapiens_hsa046722.06199884
19Nitrogen metabolism_Homo sapiens_hsa009101.97523093
20Glycerolipid metabolism_Homo sapiens_hsa005611.97066129
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.95923457
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.86714777
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.85017206
24Asthma_Homo sapiens_hsa053101.81897545
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79786435
26Oocyte meiosis_Homo sapiens_hsa041141.79450216
27Salivary secretion_Homo sapiens_hsa049701.78914861
28Lysine degradation_Homo sapiens_hsa003101.76400211
29Type I diabetes mellitus_Homo sapiens_hsa049401.74678396
30PPAR signaling pathway_Homo sapiens_hsa033201.71854214
31Dopaminergic synapse_Homo sapiens_hsa047281.71456936
32Primary immunodeficiency_Homo sapiens_hsa053401.68933952
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64133910
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.54173068
35Fructose and mannose metabolism_Homo sapiens_hsa000511.51065568
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49113917
37Staphylococcus aureus infection_Homo sapiens_hsa051501.46868054
38Antigen processing and presentation_Homo sapiens_hsa046121.46308341
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46153491
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.46139138
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.43134208
42Huntingtons disease_Homo sapiens_hsa050161.41385295
43Long-term depression_Homo sapiens_hsa047301.41205379
44Amphetamine addiction_Homo sapiens_hsa050311.40207587
45Taste transduction_Homo sapiens_hsa047421.34508332
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33394553
47Carbon metabolism_Homo sapiens_hsa012001.33132302
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32971945
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.32311872
50Nicotine addiction_Homo sapiens_hsa050331.28442019
51Fat digestion and absorption_Homo sapiens_hsa049751.23273691
52mRNA surveillance pathway_Homo sapiens_hsa030151.19958521
53RNA transport_Homo sapiens_hsa030131.18263085
54Ether lipid metabolism_Homo sapiens_hsa005651.18033121
55Olfactory transduction_Homo sapiens_hsa047401.16852383
56Renin secretion_Homo sapiens_hsa049241.12148931
57Phagosome_Homo sapiens_hsa041451.08777919
58Oxytocin signaling pathway_Homo sapiens_hsa049211.08272191
59Mineral absorption_Homo sapiens_hsa049781.05110744
60Osteoclast differentiation_Homo sapiens_hsa043801.05058693
61Pertussis_Homo sapiens_hsa051331.04894545
62Rheumatoid arthritis_Homo sapiens_hsa053231.04541909
63Morphine addiction_Homo sapiens_hsa050321.03956212
64Leishmaniasis_Homo sapiens_hsa051401.03704677
65Sphingolipid signaling pathway_Homo sapiens_hsa040711.02502535
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02137275
67Fatty acid metabolism_Homo sapiens_hsa012120.97513432
68Legionellosis_Homo sapiens_hsa051340.96564207
69Cardiac muscle contraction_Homo sapiens_hsa042600.94866231
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93985031
71Fatty acid degradation_Homo sapiens_hsa000710.93954557
72Tuberculosis_Homo sapiens_hsa051520.93663255
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91929127
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91760192
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.91272023
76Biosynthesis of amino acids_Homo sapiens_hsa012300.91207056
77Purine metabolism_Homo sapiens_hsa002300.90532032
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.89270469
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88283557
80Chemokine signaling pathway_Homo sapiens_hsa040620.86345929
81Arginine and proline metabolism_Homo sapiens_hsa003300.84887823
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84863846
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83113624
84Hematopoietic cell lineage_Homo sapiens_hsa046400.82617955
85ABC transporters_Homo sapiens_hsa020100.81692343
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81135995
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80927462
88GABAergic synapse_Homo sapiens_hsa047270.78375670
89Gastric acid secretion_Homo sapiens_hsa049710.77818706
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76739233
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.75808830
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.75714390
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.74936689
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73226858
95Renin-angiotensin system_Homo sapiens_hsa046140.70240142
96Viral myocarditis_Homo sapiens_hsa054160.68789717
97Arachidonic acid metabolism_Homo sapiens_hsa005900.68771182
98Systemic lupus erythematosus_Homo sapiens_hsa053220.67817995
99Estrogen signaling pathway_Homo sapiens_hsa049150.66964841
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66157704
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65963254
102Glutathione metabolism_Homo sapiens_hsa004800.65866477
103African trypanosomiasis_Homo sapiens_hsa051430.65130570
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64631717
105cAMP signaling pathway_Homo sapiens_hsa040240.63971952
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63895288
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.63562139
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63546247
109Long-term potentiation_Homo sapiens_hsa047200.59684379
110Glutamatergic synapse_Homo sapiens_hsa047240.57890960
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56567501
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55848198
113Cholinergic synapse_Homo sapiens_hsa047250.55254744
114Butanoate metabolism_Homo sapiens_hsa006500.55057908
115Chemical carcinogenesis_Homo sapiens_hsa052040.54989938
116Serotonergic synapse_Homo sapiens_hsa047260.54204507
117Hedgehog signaling pathway_Homo sapiens_hsa043400.52895341
118Renal cell carcinoma_Homo sapiens_hsa052110.51893617
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51686909
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50885057
121TNF signaling pathway_Homo sapiens_hsa046680.50711909
122Insulin signaling pathway_Homo sapiens_hsa049100.50504047
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.49673628
124Malaria_Homo sapiens_hsa051440.49640272
125VEGF signaling pathway_Homo sapiens_hsa043700.49290113
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48805783
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48791816
128beta-Alanine metabolism_Homo sapiens_hsa004100.46435777
129Endocytosis_Homo sapiens_hsa041440.45743901
130Regulation of autophagy_Homo sapiens_hsa041400.45591726
131Allograft rejection_Homo sapiens_hsa053300.44387294
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44270607
133AMPK signaling pathway_Homo sapiens_hsa041520.42258976
134Thyroid hormone synthesis_Homo sapiens_hsa049180.40360783
135B cell receptor signaling pathway_Homo sapiens_hsa046620.38998386
136MAPK signaling pathway_Homo sapiens_hsa040100.38416518
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38285598
138Viral carcinogenesis_Homo sapiens_hsa052030.38044807
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37357526
140Calcium signaling pathway_Homo sapiens_hsa040200.36062179
141Toxoplasmosis_Homo sapiens_hsa051450.35932218
142Graft-versus-host disease_Homo sapiens_hsa053320.33837504
143Protein digestion and absorption_Homo sapiens_hsa049740.33691950
144Measles_Homo sapiens_hsa051620.33445908
145Inositol phosphate metabolism_Homo sapiens_hsa005620.32568072
146Salmonella infection_Homo sapiens_hsa051320.32507535
147Influenza A_Homo sapiens_hsa051640.31341974
148N-Glycan biosynthesis_Homo sapiens_hsa005100.28680861
149Homologous recombination_Homo sapiens_hsa034400.28339360
150Insulin secretion_Homo sapiens_hsa049110.28236453
151Collecting duct acid secretion_Homo sapiens_hsa049660.28230692
152Bile secretion_Homo sapiens_hsa049760.28049809
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.25575173
154Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23756474
155Metabolic pathways_Homo sapiens_hsa011000.23533635
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23372124
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20501002
158RNA degradation_Homo sapiens_hsa030180.19946429
159T cell receptor signaling pathway_Homo sapiens_hsa046600.18717954
160Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16964065
161Cell cycle_Homo sapiens_hsa041100.15653201
162Pancreatic secretion_Homo sapiens_hsa049720.15530248
163Epstein-Barr virus infection_Homo sapiens_hsa051690.12766952
164Sphingolipid metabolism_Homo sapiens_hsa006000.11011461
165HIF-1 signaling pathway_Homo sapiens_hsa040660.10606451
166Autoimmune thyroid disease_Homo sapiens_hsa053200.10359878
167HTLV-I infection_Homo sapiens_hsa051660.10247331
168Alcoholism_Homo sapiens_hsa050340.09155768
169Herpes simplex infection_Homo sapiens_hsa051680.08853062

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