TRIM71

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.89052463
2nuclear pore complex assembly (GO:0051292)5.73159454
3establishment of integrated proviral latency (GO:0075713)5.66543815
4* regulation of gene silencing by miRNA (GO:0060964)5.07776562
5* regulation of gene silencing by RNA (GO:0060966)5.07776562
6* regulation of posttranscriptional gene silencing (GO:0060147)5.07776562
7DNA replication-dependent nucleosome assembly (GO:0006335)5.06737495
8DNA replication-dependent nucleosome organization (GO:0034723)5.06737495
9protein complex localization (GO:0031503)4.91067847
10pre-miRNA processing (GO:0031054)4.81962407
11L-serine metabolic process (GO:0006563)4.50658627
12IMP biosynthetic process (GO:0006188)4.37528446
13regulation of helicase activity (GO:0051095)4.37433132
14DNA replication initiation (GO:0006270)4.33579330
15pore complex assembly (GO:0046931)4.33148202
16regulation of cell fate specification (GO:0042659)4.32189204
17regulation of histone H3-K9 methylation (GO:0051570)4.29012173
18mitotic metaphase plate congression (GO:0007080)4.26990215
19protein localization to kinetochore (GO:0034501)4.25857914
20somatic hypermutation of immunoglobulin genes (GO:0016446)4.20032222
21somatic diversification of immune receptors via somatic mutation (GO:0002566)4.20032222
22mitotic nuclear envelope disassembly (GO:0007077)4.19058795
23establishment of viral latency (GO:0019043)4.16254926
24DNA unwinding involved in DNA replication (GO:0006268)4.13533617
25nucleobase biosynthetic process (GO:0046112)4.11682210
26paraxial mesoderm development (GO:0048339)4.04817556
27protein K6-linked ubiquitination (GO:0085020)3.95636061
28nuclear envelope disassembly (GO:0051081)3.91109188
29membrane disassembly (GO:0030397)3.91109188
30negative regulation of histone methylation (GO:0031061)3.90394033
31heterochromatin organization (GO:0070828)3.89497241
32metaphase plate congression (GO:0051310)3.86761450
33DNA replication checkpoint (GO:0000076)3.85449889
34lung-associated mesenchyme development (GO:0060484)3.83636022
35folic acid-containing compound biosynthetic process (GO:0009396)3.80689992
36DNA strand elongation involved in DNA replication (GO:0006271)3.79643633
37kinetochore organization (GO:0051383)3.77710520
38purine nucleobase biosynthetic process (GO:0009113)3.77471712
39histone H4-K12 acetylation (GO:0043983)3.77094972
40IMP metabolic process (GO:0046040)3.74880244
41histone arginine methylation (GO:0034969)3.72790569
42chromatin remodeling at centromere (GO:0031055)3.70426216
43ribosome assembly (GO:0042255)3.60145985
44negative regulation of gene silencing (GO:0060969)3.59774760
45DNA strand elongation (GO:0022616)3.59708700
46formation of translation preinitiation complex (GO:0001731)3.57471071
47cell fate commitment involved in formation of primary germ layer (GO:0060795)3.57208450
48mitotic sister chromatid segregation (GO:0000070)3.57045301
49DNA geometric change (GO:0032392)3.56488916
50DNA duplex unwinding (GO:0032508)3.55492304
51ribosome biogenesis (GO:0042254)3.53171310
52regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.53114375
53ATP-dependent chromatin remodeling (GO:0043044)3.50878262
54kinetochore assembly (GO:0051382)3.49833061
55L-alpha-amino acid transmembrane transport (GO:1902475)3.47178828
56protein localization to chromosome, centromeric region (GO:0071459)3.46609045
57telomere maintenance via semi-conservative replication (GO:0032201)3.44701967
58CENP-A containing nucleosome assembly (GO:0034080)3.43204574
59regulation of chromatin silencing (GO:0031935)3.42775419
60mitotic chromosome condensation (GO:0007076)3.39921041
61positive regulation of chromosome segregation (GO:0051984)3.39269225
62notochord development (GO:0030903)3.39240795
63chromatin assembly (GO:0031497)3.38906633
64meiotic chromosome segregation (GO:0045132)3.37626120
65mitotic sister chromatid cohesion (GO:0007064)3.34907363
66cellular protein complex localization (GO:0034629)3.33506777
67regulation of centriole replication (GO:0046599)3.33137653
68regulation of nuclear cell cycle DNA replication (GO:0033262)3.32285695
69DNA replication-independent nucleosome organization (GO:0034724)3.31883954
70DNA replication-independent nucleosome assembly (GO:0006336)3.31883954
71regulation of SMAD protein import into nucleus (GO:0060390)3.31728604
72regulation of centrosome cycle (GO:0046605)3.31540912
73establishment of chromosome localization (GO:0051303)3.28601237
74attachment of spindle microtubules to kinetochore (GO:0008608)3.28058235
75* regulation of gene silencing (GO:0060968)3.26403624
76maturation of SSU-rRNA (GO:0030490)3.24642343
77sister chromatid segregation (GO:0000819)3.24387608
78negative regulation of chromosome segregation (GO:0051985)3.21834290
79regulation of spindle organization (GO:0090224)3.21482113
80histone exchange (GO:0043486)3.21253909
81determination of adult lifespan (GO:0008340)3.19047811
82anterior/posterior axis specification, embryo (GO:0008595)3.17702297
83chromatin assembly or disassembly (GO:0006333)3.17362525
84convergent extension (GO:0060026)3.17184133
85non-recombinational repair (GO:0000726)3.15984572
86double-strand break repair via nonhomologous end joining (GO:0006303)3.15984572
87positive regulation of catenin import into nucleus (GO:0035413)3.15307574
88regulation of telomere maintenance via telomerase (GO:0032210)3.15257173
89lysine catabolic process (GO:0006554)3.13905323
90lysine metabolic process (GO:0006553)3.13905323
91spindle checkpoint (GO:0031577)3.13458340
92telomere maintenance via recombination (GO:0000722)3.12007111
93positive regulation of SMAD protein import into nucleus (GO:0060391)3.11383391
94nucleosome disassembly (GO:0006337)3.10902118
95protein-DNA complex disassembly (GO:0032986)3.10902118
96positive regulation of mitotic sister chromatid separation (GO:1901970)3.10710844
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10710844
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10710844
99mitotic recombination (GO:0006312)3.10520178
100negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09727711
101negative regulation of sister chromatid segregation (GO:0033046)3.09727711
102negative regulation of mitotic sister chromatid separation (GO:2000816)3.09727711
103negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09727711
104regulation of mitotic spindle organization (GO:0060236)3.08343589
105regulation of chromosome segregation (GO:0051983)3.08142403
106regulation of mitotic spindle checkpoint (GO:1903504)3.07707485
107regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07707485
108regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07615071
109regulation of translational fidelity (GO:0006450)3.07397983
110mitotic spindle checkpoint (GO:0071174)3.07384889
111negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06017587
112spindle assembly checkpoint (GO:0071173)3.05545272
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04859522
114regulation of sister chromatid cohesion (GO:0007063)3.02894295
115telomere maintenance via telomere lengthening (GO:0010833)3.02422122
116mismatch repair (GO:0006298)3.02120038
117histone H2A monoubiquitination (GO:0035518)3.01915252
118regulation of stem cell maintenance (GO:2000036)3.01728260
119ncRNA catabolic process (GO:0034661)3.01614513
120regulation of cell fate commitment (GO:0010453)3.01313915
121inner cell mass cell proliferation (GO:0001833)3.01218577
122mitotic spindle assembly checkpoint (GO:0007094)3.01132306
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00458928
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00404683
125regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99213942
126regulation of sister chromatid segregation (GO:0033045)2.99207425
127regulation of mitotic sister chromatid separation (GO:0010965)2.99207425
128regulation of mitotic sister chromatid segregation (GO:0033047)2.99207425
129ribonucleoprotein complex biogenesis (GO:0022613)2.98784362
130regulation of DNA methylation (GO:0044030)2.97935307
131mRNA transport (GO:0051028)2.97708027
132regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.95300703
133mitotic G2/M transition checkpoint (GO:0044818)2.93104215
134serine family amino acid biosynthetic process (GO:0009070)2.89343624
135dorsal/ventral axis specification (GO:0009950)2.86910581
136DNA damage response, detection of DNA damage (GO:0042769)2.85816442
137DNA ligation (GO:0006266)2.85297404
138positive regulation of histone H3-K4 methylation (GO:0051571)2.84955906
139negative regulation of androgen receptor signaling pathway (GO:0060766)2.84910491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.23575305
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.12871154
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.02045758
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.79536624
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.18406021
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.18406021
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.18406021
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10705652
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97087743
10* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.87378844
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80194114
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77511745
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.70212916
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59169800
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41640595
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.40976186
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38543858
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.33575814
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.33282310
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32575118
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.27212928
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27081273
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25373636
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.16883079
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15030130
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.13051802
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.05310087
28SOX2_18555785_ChIP-Seq_MESCs_Mouse2.04161481
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04076926
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.00536953
31TCF3_18692474_ChIP-Seq_MEFs_Mouse1.96821119
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90840271
33* E2F1_21310950_ChIP-Seq_MCF-7_Human1.90333964
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.90289336
35XRN2_22483619_ChIP-Seq_HELA_Human1.89052475
36* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.88963704
37AR_21909140_ChIP-Seq_LNCAP_Human1.88442758
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88227366
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87845473
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85824173
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.85138666
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84317323
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80638731
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77660073
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77281799
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76382968
47* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76093432
48SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.72467832
49* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66566627
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65129269
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.62238038
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.60770830
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.54390859
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51921714
55NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.51549071
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49686028
57VDR_23849224_ChIP-Seq_CD4+_Human1.48309615
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47412262
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46512942
60TTF2_22483619_ChIP-Seq_HELA_Human1.46159674
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41410434
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39030989
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.33164310
64FOXP3_21729870_ChIP-Seq_TREG_Human1.32795473
65* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31883787
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30694088
67DCP1A_22483619_ChIP-Seq_HELA_Human1.30320172
68* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.29356404
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29235769
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28022156
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.27204962
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.26891539
73SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.26022534
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25332386
75* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24551963
76GABP_19822575_ChIP-Seq_HepG2_Human1.24253062
77SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22331431
78KDM5A_27292631_Chip-Seq_BREAST_Human1.20351557
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19194001
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16462167
81ELK1_19687146_ChIP-ChIP_HELA_Human1.16392973
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14795342
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14075918
84MYC_18940864_ChIP-ChIP_HL60_Human1.12417448
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11807208
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11521991
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10943281
88TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10856872
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10736369
90* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09942870
91TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09512314
92NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08930684
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08022561
94* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06957663
95SOX17_20123909_ChIP-Seq_XEN_Mouse1.05862776
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05673085
97* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04262557
98* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03841115
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02809810
100SOX2_16153702_ChIP-ChIP_HESCs_Human1.02189845
101MYC_22102868_ChIP-Seq_BL_Human1.01989930
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.01386485
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00540072
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99855394
105CIITA_25753668_ChIP-Seq_RAJI_Human0.99308814
106* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99224127
107NANOG_16518401_ChIP-PET_MESCs_Mouse0.96961972
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95633383
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95095509
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.94399616
111TFEB_21752829_ChIP-Seq_HELA_Human0.94300614
112EWS_26573619_Chip-Seq_HEK293_Human0.92961891
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92630188
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90065279
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90015040
116KAP1_27257070_Chip-Seq_ESCs_Mouse0.88000977
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86311405
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85719592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.29320624
2MP0010094_abnormal_chromosome_stability4.27092775
3MP0003693_abnormal_embryo_hatching4.18322893
4MP0004957_abnormal_blastocyst_morpholog4.07097164
5MP0008057_abnormal_DNA_replication4.06441372
6MP0003111_abnormal_nucleus_morphology3.94415562
7MP0003077_abnormal_cell_cycle3.47081055
8MP0003123_paternal_imprinting3.26629394
9MP0008877_abnormal_DNA_methylation3.19634750
10MP0008058_abnormal_DNA_repair3.07870176
11MP0001730_embryonic_growth_arrest2.60601324
12MP0003890_abnormal_embryonic-extraembry2.58044148
13MP0010352_gastrointestinal_tract_polyps2.44520218
14MP0008932_abnormal_embryonic_tissue2.42480529
15MP0000350_abnormal_cell_proliferation2.31774577
16MP0008007_abnormal_cellular_replicative2.23281759
17MP0003121_genomic_imprinting2.19869304
18MP0005380_embryogenesis_phenotype2.19458586
19MP0001672_abnormal_embryogenesis/_devel2.19458586
20MP0002084_abnormal_developmental_patter2.14740389
21MP0004133_heterotaxia2.14008620
22MP0003119_abnormal_digestive_system2.08189923
23MP0002653_abnormal_ependyma_morphology2.05529316
24* MP0002085_abnormal_embryonic_tissue2.03277787
25MP0003786_premature_aging2.02634700
26MP0010307_abnormal_tumor_latency2.00727446
27MP0001697_abnormal_embryo_size2.00724023
28MP0003806_abnormal_nucleotide_metabolis2.00450112
29MP0001293_anophthalmia1.94620605
30MP0003941_abnormal_skin_development1.93813150
31MP0003984_embryonic_growth_retardation1.91999418
32MP0010030_abnormal_orbit_morphology1.89397027
33MP0002088_abnormal_embryonic_growth/wei1.88772760
34MP0002086_abnormal_extraembryonic_tissu1.84593777
35* MP0004197_abnormal_fetal_growth/weight/1.80859369
36MP0006292_abnormal_olfactory_placode1.73218888
37MP0001299_abnormal_eye_distance/1.72464755
38MP0005076_abnormal_cell_differentiation1.70625617
39* MP0002080_prenatal_lethality1.59966255
40MP0003567_abnormal_fetal_cardiomyocyte1.57012157
41MP0005377_hearing/vestibular/ear_phenot1.56250374
42MP0003878_abnormal_ear_physiology1.56250374
43MP0002210_abnormal_sex_determination1.52816216
44MP0003718_maternal_effect1.51458634
45MP0002938_white_spotting1.45918109
46MP0001188_hyperpigmentation1.45113717
47MP0003315_abnormal_perineum_morphology1.43543477
48MP0005367_renal/urinary_system_phenotyp1.43073283
49MP0000516_abnormal_urinary_system1.43073283
50MP0003705_abnormal_hypodermis_morpholog1.37572432
51MP0001145_abnormal_male_reproductive1.34944579
52MP0000537_abnormal_urethra_morphology1.34047848
53MP0003937_abnormal_limbs/digits/tail_de1.30706472
54MP0009053_abnormal_anal_canal1.28360517
55MP0009672_abnormal_birth_weight1.21980273
56MP0000313_abnormal_cell_death1.19361790
57MP0003136_yellow_coat_color1.19196675
58MP0002111_abnormal_tail_morphology1.18629503
59MP0001849_ear_inflammation1.16299329
60MP0001929_abnormal_gametogenesis1.15930056
61MP0009703_decreased_birth_body1.14578446
62MP0000653_abnormal_sex_gland1.13162437
63MP0000579_abnormal_nail_morphology1.12835564
64MP0004264_abnormal_extraembryonic_tissu1.12733962
65MP0009697_abnormal_copulation1.12270307
66MP0003283_abnormal_digestive_organ1.12168110
67MP0001286_abnormal_eye_development1.07408368
68MP0002697_abnormal_eye_size1.06717188
69MP0003566_abnormal_cell_adhesion1.03604643
70MP0004272_abnormal_basement_membrane1.02097013
71* MP0002233_abnormal_nose_morphology0.97790700
72* MP0003861_abnormal_nervous_system0.97295983
73MP0000490_abnormal_crypts_of0.94023909
74MP0003787_abnormal_imprinting0.93602524
75MP0002092_abnormal_eye_morphology0.91990573
76MP0002089_abnormal_postnatal_growth/wei0.91732934
77* MP0000432_abnormal_head_morphology0.90054497
78MP0002019_abnormal_tumor_incidence0.89454075
79MP0002160_abnormal_reproductive_system0.88241595
80MP0005623_abnormal_meninges_morphology0.87866863
81MP0003938_abnormal_ear_development0.86403354
82MP0005266_abnormal_metabolism0.85338082
83MP0003942_abnormal_urinary_system0.84588852
84MP0003936_abnormal_reproductive_system0.81744689
85MP0002249_abnormal_larynx_morphology0.81740930
86MP0001119_abnormal_female_reproductive0.81484686
87MP0002796_impaired_skin_barrier0.79018076
88MP0001915_intracranial_hemorrhage0.78686055
89MP0000428_abnormal_craniofacial_morphol0.77828748
90MP0002925_abnormal_cardiovascular_devel0.77819887
91MP0001485_abnormal_pinna_reflex0.77113816
92MP0003935_abnormal_craniofacial_develop0.76242890
93MP0005394_taste/olfaction_phenotype0.76111841
94MP0005499_abnormal_olfactory_system0.76111841
95MP0001177_atelectasis0.75244667
96MP0003698_abnormal_male_reproductive0.75028602
97MP0002081_perinatal_lethality0.74683700
98MP0008995_early_reproductive_senescence0.74223340
99MP0003385_abnormal_body_wall0.74038719
100MP0005384_cellular_phenotype0.73000125
101MP0001346_abnormal_lacrimal_gland0.72966164
102MP0003755_abnormal_palate_morphology0.72713059
103MP0000762_abnormal_tongue_morphology0.72001947
104MP0003122_maternal_imprinting0.71541784
105MP0002127_abnormal_cardiovascular_syste0.71405727
106MP0010234_abnormal_vibrissa_follicle0.69757575
107MP0004233_abnormal_muscle_weight0.68157692
108MP0005023_abnormal_wound_healing0.67040068
109MP0005621_abnormal_cell_physiology0.65779885
110MP0002116_abnormal_craniofacial_bone0.64376997
111MP0002114_abnormal_axial_skeleton0.64192213
112MP0002090_abnormal_vision0.64030604
113MP0003950_abnormal_plasma_membrane0.63311370
114MP0003115_abnormal_respiratory_system0.63105407
115MP0000566_synostosis0.62558486
116MP0002161_abnormal_fertility/fecundity0.61721902
117MP0005389_reproductive_system_phenotype0.61625457
118MP0000049_abnormal_middle_ear0.61212287
119MP0001661_extended_life_span0.59979860
120MP0008789_abnormal_olfactory_epithelium0.59560735
121MP0006035_abnormal_mitochondrial_morpho0.59349038
122MP0008770_decreased_survivor_rate0.59006028
123MP0002396_abnormal_hematopoietic_system0.58396656
124MP0006072_abnormal_retinal_apoptosis0.57898297
125MP0002751_abnormal_autonomic_nervous0.57708970
126MP0000647_abnormal_sebaceous_gland0.57683609
127MP0005501_abnormal_skin_physiology0.56964205
128MP0000631_abnormal_neuroendocrine_gland0.55960016
129MP0004185_abnormal_adipocyte_glucose0.55852296
130MP0005391_vision/eye_phenotype0.54981421

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.04953720
2Hepatoblastoma (HP:0002884)4.70648651
3Abnormality of the labia minora (HP:0012880)4.40800368
4Chromsome breakage (HP:0040012)4.14468827
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.04588292
6Septo-optic dysplasia (HP:0100842)4.03976453
7Medulloblastoma (HP:0002885)4.02872625
8Absent radius (HP:0003974)3.80659550
9Birth length less than 3rd percentile (HP:0003561)3.71489978
10Supernumerary spleens (HP:0009799)3.67742665
11Astrocytoma (HP:0009592)3.66324606
12Abnormality of the astrocytes (HP:0100707)3.66324606
13Spastic diplegia (HP:0001264)3.63235637
14Absent forearm bone (HP:0003953)3.57951439
15Aplasia involving forearm bones (HP:0009822)3.57951439
16Choanal stenosis (HP:0000452)3.53871170
17Colon cancer (HP:0003003)3.47522274
18Rhabdomyosarcoma (HP:0002859)3.46001610
19Breast hypoplasia (HP:0003187)3.37392311
20Agnosia (HP:0010524)3.36795713
21Neoplasm of the oral cavity (HP:0100649)3.33632494
22Aplasia/hypoplasia of the humerus (HP:0006507)3.31577300
23Impulsivity (HP:0100710)3.30153101
24Carpal bone hypoplasia (HP:0001498)3.26992880
25Selective tooth agenesis (HP:0001592)3.24100813
26Short humerus (HP:0005792)3.17412556
27Rectal fistula (HP:0100590)3.14647203
28Rectovaginal fistula (HP:0000143)3.14647203
29Glioma (HP:0009733)3.13396029
30Bilateral microphthalmos (HP:0007633)3.12689307
31Rib fusion (HP:0000902)3.09076242
32Absent thumb (HP:0009777)2.99732927
33Patellar aplasia (HP:0006443)2.98635932
34Abnormality of chromosome stability (HP:0003220)2.91964193
35Meckel diverticulum (HP:0002245)2.91271332
36Intestinal fistula (HP:0100819)2.87233646
37Neoplasm of striated muscle (HP:0009728)2.83828584
38Cortical dysplasia (HP:0002539)2.82763308
39Abnormality of the ileum (HP:0001549)2.82288756
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.76489808
41Aplasia/Hypoplasia of the patella (HP:0006498)2.75308693
42Shawl scrotum (HP:0000049)2.74164372
43Missing ribs (HP:0000921)2.73404916
44Ectopic kidney (HP:0000086)2.70559442
45Stenosis of the external auditory canal (HP:0000402)2.69316653
46Partial duplication of thumb phalanx (HP:0009944)2.67892881
47Maternal diabetes (HP:0009800)2.66186957
48Biliary tract neoplasm (HP:0100574)2.63553924
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.62505876
50Abnormality of abdominal situs (HP:0011620)2.57911176
51Abdominal situs inversus (HP:0003363)2.57911176
52Abnormality of the preputium (HP:0100587)2.55693795
53Vaginal fistula (HP:0004320)2.55335512
54Abnormality of the septum pellucidum (HP:0007375)2.54266182
55Abnormal number of incisors (HP:0011064)2.53864353
56Chronic bronchitis (HP:0004469)2.52703578
57Reticulocytopenia (HP:0001896)2.52525560
58Broad thumb (HP:0011304)2.52088270
59Pancreatic islet-cell hyperplasia (HP:0004510)2.46556224
60Esophageal atresia (HP:0002032)2.46088354
61Anal stenosis (HP:0002025)2.46061354
62Multiple enchondromatosis (HP:0005701)2.45614700
63Absent septum pellucidum (HP:0001331)2.44080808
64Increased nuchal translucency (HP:0010880)2.41724748
65Hypoglycemic seizures (HP:0002173)2.41487070
66Absent eyebrow (HP:0002223)2.41189964
67Myelomeningocele (HP:0002475)2.37555200
68Hyperglycinemia (HP:0002154)2.37397546
69Abnormal lung lobation (HP:0002101)2.35689616
70Abnormality of the anterior horn cell (HP:0006802)2.33274760
71Degeneration of anterior horn cells (HP:0002398)2.33274760
72Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.32930184
73Short 1st metacarpal (HP:0010034)2.32930184
74Small intestinal stenosis (HP:0012848)2.30966341
75Duodenal stenosis (HP:0100867)2.30966341
76Deviation of the thumb (HP:0009603)2.30962953
77Duplication of thumb phalanx (HP:0009942)2.30825044
78Nephroblastoma (Wilms tumor) (HP:0002667)2.29503136
79Fused cervical vertebrae (HP:0002949)2.29316531
80Proximal placement of thumb (HP:0009623)2.28573912
81Bifid tongue (HP:0010297)2.27032718
82Anophthalmia (HP:0000528)2.26985579
83Horseshoe kidney (HP:0000085)2.25409696
84Abnormality of the salivary glands (HP:0010286)2.25186919
85Neoplasm of the adrenal cortex (HP:0100641)2.22556271
86Embryonal neoplasm (HP:0002898)2.21851330
87Basal cell carcinoma (HP:0002671)2.21254784
88Facial cleft (HP:0002006)2.21104186
89Abnormality of the lacrimal duct (HP:0011481)2.20491144
90Duplicated collecting system (HP:0000081)2.20065699
91Short hallux (HP:0010109)2.19888879
92Aplasia/Hypoplasia of the sternum (HP:0006714)2.19490844
93Aqueductal stenosis (HP:0002410)2.17221317
94Partial duplication of the phalanx of hand (HP:0009999)2.16839531
95Abnormality of the lower motor neuron (HP:0002366)2.15887628
96Hyperglycinuria (HP:0003108)2.15738815
97Embryonal renal neoplasm (HP:0011794)2.13651495
98Abnormality of the duodenum (HP:0002246)2.13631611
99Short thumb (HP:0009778)2.12942561
100Supernumerary bones of the axial skeleton (HP:0009144)2.12783288
101Preaxial foot polydactyly (HP:0001841)2.12212344
102Facial hemangioma (HP:0000329)2.10677870
103Supernumerary ribs (HP:0005815)2.10637209
10411 pairs of ribs (HP:0000878)2.08924301
105Aplasia/Hypoplasia of the hallux (HP:0008362)2.07253851
106Neoplasm of the pancreas (HP:0002894)2.06534312
107Tracheoesophageal fistula (HP:0002575)2.06148847
108Cutaneous syndactyly (HP:0012725)2.02951666
109High anterior hairline (HP:0009890)2.01767804
110Gastrointestinal atresia (HP:0002589)2.01552883
111Vertebral fusion (HP:0002948)2.00936849
112Sloping forehead (HP:0000340)2.00869743
113Abnormality of the 1st metacarpal (HP:0010009)2.00819754
114Diastasis recti (HP:0001540)2.00644557
115Cafe-au-lait spot (HP:0000957)2.00160435
116Oral leukoplakia (HP:0002745)1.99409649
117Breast aplasia (HP:0100783)1.98933289
118Triphalangeal thumb (HP:0001199)1.98713938
119Gastrointestinal carcinoma (HP:0002672)1.98172311
120Malignant gastrointestinal tract tumors (HP:0006749)1.98172311
121Neoplasm of the colon (HP:0100273)1.95243059
122Abnormality of pyrimidine metabolism (HP:0004353)1.94352557
123Myelodysplasia (HP:0002863)1.94314404
124Omphalocele (HP:0001539)1.94142219
125Trigonocephaly (HP:0000243)1.94127742
126Aplasia/Hypoplasia of the breasts (HP:0010311)1.93997317
127Amaurosis fugax (HP:0100576)1.93740742
128Abnormality of serine family amino acid metabolism (HP:0010894)1.93437422
129Abnormality of glycine metabolism (HP:0010895)1.93437422
130Uterine neoplasm (HP:0010784)1.93207276
131Bronchomalacia (HP:0002780)1.92850382
132Short phalanx of the thumb (HP:0009660)1.92228077
133Absent eyelashes (HP:0000561)1.90946556
134Cellular immunodeficiency (HP:0005374)1.90120922
135Asplenia (HP:0001746)1.89617245
136Turricephaly (HP:0000262)1.88950261
137Broad phalanges of the hand (HP:0009768)1.88778197
138Volvulus (HP:0002580)1.87761247
139Hemivertebrae (HP:0002937)1.87692537
140Coronal craniosynostosis (HP:0004440)1.87456906
141Ovarian neoplasm (HP:0100615)1.87108870
142Atresia of the external auditory canal (HP:0000413)1.87083725
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86402459
144Intestinal atresia (HP:0011100)1.86377899
145Abnormality of the carotid arteries (HP:0005344)1.84258401
146Skull defect (HP:0001362)1.84163943
147Abnormality of the nasolacrimal system (HP:0000614)1.83425730
148Premature ovarian failure (HP:0008209)1.83218663
149Pseudobulbar signs (HP:0002200)1.83189887
150Broad finger (HP:0001500)1.82377798
151Abnormality of homocysteine metabolism (HP:0010919)1.80175487
152Homocystinuria (HP:0002156)1.80175487
153Cutaneous finger syndactyly (HP:0010554)1.77897404
154Abnormality of the middle phalanges of the toes (HP:0010183)1.76967206
155Aplasia of the phalanges of the hand (HP:0009802)1.76140936
156Aplasia involving bones of the extremities (HP:0009825)1.76140936
157Aplasia involving bones of the upper limbs (HP:0009823)1.76140936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.51221170
2CDC74.31560862
3WEE13.82172984
4EPHA23.11808653
5SRPK12.85973722
6TTK2.85427131
7BUB12.85104549
8TAF12.82593546
9NEK12.53732751
10TLK12.39866336
11NEK22.34602460
12VRK22.25358346
13TNIK2.16948006
14PLK12.14236315
15FGFR22.04149562
16TSSK62.03626928
17CDK192.01202530
18CDK71.97550835
19STK38L1.91790627
20PNCK1.90619563
21EIF2AK11.87893458
22BRD41.87231809
23RPS6KB21.87160050
24PLK31.86506761
25CHEK21.85100975
26ZAK1.83662995
27PLK41.83097999
28AKT31.81392107
29ACVR1B1.78203540
30SMG11.77581931
31MKNK11.76328809
32MKNK21.68061755
33BRSK21.66783776
34ATR1.66386124
35PASK1.57018734
36CHEK11.55349860
37LATS21.54432157
38AURKB1.52312797
39CAMK1D1.39305225
40CAMK1G1.34564341
41VRK11.33876309
42ALK1.31793814
43ATM1.23958573
44CDK41.23018205
45AURKA1.22734264
46MAP3K81.19486303
47STK41.17221545
48CASK1.13436773
49SCYL21.12730853
50CDK21.12532660
51FLT31.11703181
52FGFR41.10623806
53LATS11.07254189
54NUAK11.06243965
55DYRK31.04049264
56EIF2AK31.00598149
57NLK1.00030420
58MELK0.96438935
59PAK40.86808226
60STK100.86522982
61MTOR0.86220543
62BRSK10.82739849
63CDK10.82320766
64PRKCI0.82309511
65PIM10.81232857
66TRIM280.80570919
67MET0.80309460
68ICK0.80026414
69STK30.75219974
70CSNK1G10.74740790
71CDK60.74569599
72TESK20.73921099
73ERBB40.72526961
74TGFBR10.70804097
75CSNK2A20.70519876
76CSNK1D0.70131773
77CSNK1E0.67801940
78PKN20.67519619
79NME10.67459754
80PDGFRA0.65326761
81STK160.61537221
82MST40.59486340
83WNK30.58628521
84TIE10.58237478
85PBK0.58224875
86EEF2K0.57523394
87BRAF0.57269882
88PRKDC0.56611725
89FGFR10.56589500
90AKT20.55916789
91CSNK2A10.53129494
92RPS6KA50.52737927
93BCR0.51860999
94MAP3K40.51507612
95FGR0.49881342
96OXSR10.49453372
97PDK30.48734016
98PDK40.48734016
99MAP3K100.47992515
100MAPK140.47152268
101PAK10.47041195
102DYRK1A0.46323221
103TYRO30.45863823
104EIF2AK20.42728044
105EGFR0.42371218
106PDK20.42069898
107DMPK0.41300204
108KDR0.40590017
109GSK3B0.40161403
110DYRK20.36945152
111PLK20.34772747
112AKT10.34370209
113CSNK1G20.34336619
114MAPK10.33469544
115NTRK10.32686032
116DAPK10.32096205
117CDK180.30974108
118RPS6KA40.30430526
119YES10.28493301
120CDK90.27994101
121MAPK100.27854448
122STK240.27524131
123MARK30.26387700
124MAP3K90.23844027
125MAPKAPK30.23308242
126KSR10.22986419
127RPS6KB10.20272950
128RPS6KA10.18252863
129PAK20.17797959
130NEK60.17243518
131BMX0.17239816

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.72843412
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.46918059
3DNA replication_Homo sapiens_hsa030304.42865264
4RNA transport_Homo sapiens_hsa030133.58135129
5One carbon pool by folate_Homo sapiens_hsa006703.34823564
6Spliceosome_Homo sapiens_hsa030403.22165122
7Homologous recombination_Homo sapiens_hsa034403.05347324
8RNA polymerase_Homo sapiens_hsa030203.01337408
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91537146
10Nucleotide excision repair_Homo sapiens_hsa034202.89525937
11Cell cycle_Homo sapiens_hsa041102.79110262
12Base excision repair_Homo sapiens_hsa034102.61117870
13Fanconi anemia pathway_Homo sapiens_hsa034602.60975108
14mRNA surveillance pathway_Homo sapiens_hsa030152.34207982
15Basal transcription factors_Homo sapiens_hsa030222.26580743
16Non-homologous end-joining_Homo sapiens_hsa034502.21338853
17Systemic lupus erythematosus_Homo sapiens_hsa053222.13588204
18Ribosome_Homo sapiens_hsa030102.08769115
19Proteasome_Homo sapiens_hsa030502.08432137
20RNA degradation_Homo sapiens_hsa030182.04394552
21Pyrimidine metabolism_Homo sapiens_hsa002401.95126045
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55505559
23p53 signaling pathway_Homo sapiens_hsa041151.55200230
24Steroid biosynthesis_Homo sapiens_hsa001001.50714050
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50298979
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.32105579
27Oocyte meiosis_Homo sapiens_hsa041141.25196283
28Pyruvate metabolism_Homo sapiens_hsa006201.19513079
29Hippo signaling pathway_Homo sapiens_hsa043901.17600902
30Selenocompound metabolism_Homo sapiens_hsa004501.15816602
31Basal cell carcinoma_Homo sapiens_hsa052171.15260220
32Viral carcinogenesis_Homo sapiens_hsa052031.12945638
33Biosynthesis of amino acids_Homo sapiens_hsa012301.10776399
34Vitamin digestion and absorption_Homo sapiens_hsa049771.06699215
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05893478
36Purine metabolism_Homo sapiens_hsa002301.04800723
37Alcoholism_Homo sapiens_hsa050341.02007857
38Epstein-Barr virus infection_Homo sapiens_hsa051690.95360519
39Thyroid cancer_Homo sapiens_hsa052160.94233020
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93732990
41TGF-beta signaling pathway_Homo sapiens_hsa043500.93044559
42Propanoate metabolism_Homo sapiens_hsa006400.92179558
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.91920406
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89271832
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86338295
46* MicroRNAs in cancer_Homo sapiens_hsa052060.85109329
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83798492
48Adherens junction_Homo sapiens_hsa045200.83761551
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82060700
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.80277667
51Hedgehog signaling pathway_Homo sapiens_hsa043400.80225159
52Protein export_Homo sapiens_hsa030600.73855083
53Tight junction_Homo sapiens_hsa045300.71018655
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69079665
55Notch signaling pathway_Homo sapiens_hsa043300.68271141
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67633241
57HTLV-I infection_Homo sapiens_hsa051660.65537345
58Herpes simplex infection_Homo sapiens_hsa051680.65057953
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63042131
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62661229
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61657338
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60409073
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59815953
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.58976261
65Lysine degradation_Homo sapiens_hsa003100.57270157
66Arginine biosynthesis_Homo sapiens_hsa002200.57176606
67Fructose and mannose metabolism_Homo sapiens_hsa000510.54393496
68Fatty acid elongation_Homo sapiens_hsa000620.51171370
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.50654763
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50652749
71mTOR signaling pathway_Homo sapiens_hsa041500.50431285
72Wnt signaling pathway_Homo sapiens_hsa043100.50018213
73Fat digestion and absorption_Homo sapiens_hsa049750.49895435
74Carbon metabolism_Homo sapiens_hsa012000.49867910
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49750127
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47897611
77Antigen processing and presentation_Homo sapiens_hsa046120.47699512
78Fatty acid metabolism_Homo sapiens_hsa012120.47518051
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46820686
80Colorectal cancer_Homo sapiens_hsa052100.45795896
81Small cell lung cancer_Homo sapiens_hsa052220.43928303
82Bladder cancer_Homo sapiens_hsa052190.42590979
83Pathways in cancer_Homo sapiens_hsa052000.42392095
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39274182
85Folate biosynthesis_Homo sapiens_hsa007900.35870922
86HIF-1 signaling pathway_Homo sapiens_hsa040660.34659806
87Pentose phosphate pathway_Homo sapiens_hsa000300.33992282
88Vitamin B6 metabolism_Homo sapiens_hsa007500.33435225
89Starch and sucrose metabolism_Homo sapiens_hsa005000.33169841
90Glutathione metabolism_Homo sapiens_hsa004800.32546146
91Fatty acid degradation_Homo sapiens_hsa000710.32526991
92Renin-angiotensin system_Homo sapiens_hsa046140.30441494
93Huntingtons disease_Homo sapiens_hsa050160.28656921
94Axon guidance_Homo sapiens_hsa043600.26601032
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25203000
96Galactose metabolism_Homo sapiens_hsa000520.24777207
97Melanoma_Homo sapiens_hsa052180.24435291
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24380149
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24242567
100Prostate cancer_Homo sapiens_hsa052150.23894125
101beta-Alanine metabolism_Homo sapiens_hsa004100.22181648
102N-Glycan biosynthesis_Homo sapiens_hsa005100.21002444
103Retinol metabolism_Homo sapiens_hsa008300.20564345
104Proteoglycans in cancer_Homo sapiens_hsa052050.16648128
105Thyroid hormone synthesis_Homo sapiens_hsa049180.16160799
106Fatty acid biosynthesis_Homo sapiens_hsa000610.15789846
107Endometrial cancer_Homo sapiens_hsa052130.15597749
108Arginine and proline metabolism_Homo sapiens_hsa003300.13695533
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13085956
110Linoleic acid metabolism_Homo sapiens_hsa005910.13077442
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12296781
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12101134
113Apoptosis_Homo sapiens_hsa042100.08535625
114FoxO signaling pathway_Homo sapiens_hsa040680.07717648
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07440386
116Arachidonic acid metabolism_Homo sapiens_hsa005900.07322531
117Legionellosis_Homo sapiens_hsa051340.06897411
118Metabolic pathways_Homo sapiens_hsa011000.05892525
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.05589199
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.01285254
121Chronic myeloid leukemia_Homo sapiens_hsa05220-0.0485034
122Rap1 signaling pathway_Homo sapiens_hsa04015-0.0389821
123Glucagon signaling pathway_Homo sapiens_hsa04922-0.0378903
124Melanogenesis_Homo sapiens_hsa04916-0.0332978
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0283462
126AMPK signaling pathway_Homo sapiens_hsa04152-0.0172324
127alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0143590
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130-0.0124075

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