ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of erythrocyte differentiation (GO:0045647)	5.27962163
2	cellular response to exogenous dsRNA (GO:0071360)	4.67211048
3	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	4.60982463
4	positive thymic T cell selection (GO:0045059)	4.56867457
5	negative regulation of B cell apoptotic process (GO:0002903)	4.46248796
6	positive regulation of granulocyte differentiation (GO:0030854)	4.45220979
7	positive regulation of B cell differentiation (GO:0045579)	4.36890334
8	chaperone mediated protein folding requiring cofactor (GO:0051085)	4.20429008
9	cellular response to interferon-beta (GO:0035458)	4.12653461
10	response to muramyl dipeptide (GO:0032495)	4.03179771
11	definitive hemopoiesis (GO:0060216)	3.89379743
12	mannose metabolic process (GO:0006013)	3.88784246
13	response to peptidoglycan (GO:0032494)	3.86738567
14	response to protozoan (GO:0001562)	3.83714342
15	defense response to protozoan (GO:0042832)	3.83516257
16	UV protection (GO:0009650)	3.75967170
17	dosage compensation (GO:0007549)	3.71646379
18	response to interferon-beta (GO:0035456)	3.71274845
19	thrombin receptor signaling pathway (GO:0070493)	3.66910897
20	purine nucleotide salvage (GO:0032261)	3.63917300
21	autophagic vacuole fusion (GO:0000046)	3.60663852
22	negative thymic T cell selection (GO:0045060)	3.58480775
23	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.52645470
24	regulation of hydrogen peroxide metabolic process (GO:0010310)	3.51098352
25	protein polyglutamylation (GO:0018095)	3.46577572
26	regulation of erythrocyte differentiation (GO:0045646)	3.46286380
27	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.44191562
28	pentose metabolic process (GO:0019321)	3.38770832
29	regulation of B cell apoptotic process (GO:0002902)	3.37192821
30	regulation of respiratory burst (GO:0060263)	3.27908076
31	oligosaccharide catabolic process (GO:0009313)	3.26438384
32	sleep (GO:0030431)	3.25325854
33	thymic T cell selection (GO:0045061)	3.24410930
34	regulation of B cell differentiation (GO:0045577)	3.23095225
35	negative T cell selection (GO:0043383)	3.23038584
36	regulation of granulocyte differentiation (GO:0030852)	3.23035994
37	mast cell degranulation (GO:0043303)	3.23026097
38	mast cell activation involved in immune response (GO:0002279)	3.23026097
39	peptidyl-arginine omega-N-methylation (GO:0035247)	3.22632038
40	leukocyte aggregation (GO:0070486)	3.17581035
41	imidazole-containing compound metabolic process (GO:0052803)	3.15331391
42	phosphatidylglycerol biosynthetic process (GO:0006655)	3.14225343
43	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.10222723
44	pinocytosis (GO:0006907)	3.10151772
45	positive T cell selection (GO:0043368)	3.09806774
46	immunoglobulin mediated immune response (GO:0016064)	3.09217546
47	antigen processing and presentation of endogenous antigen (GO:0019883)	3.05425990
48	regulation of antigen processing and presentation (GO:0002577)	3.03146378
49	DNA deamination (GO:0045006)	2.97783518
50	histone H2A acetylation (GO:0043968)	2.97464610
51	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.92530324
52	response to gravity (GO:0009629)	2.90940573
53	organelle membrane fusion (GO:0090174)	2.89212943
54	nucleotide salvage (GO:0043173)	2.89007607
55	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.84997445
56	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.84997445
57	peptidyl-lysine trimethylation (GO:0018023)	2.84429182
58	endothelium development (GO:0003158)	2.82534230
59	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.81605503
60	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.81371941
61	grooming behavior (GO:0007625)	2.78249201
62	Peyers patch development (GO:0048541)	2.75063614
63	mucosal-associated lymphoid tissue development (GO:0048537)	2.75063614
64	estrogen biosynthetic process (GO:0006703)	2.74094470
65	cellular hyperosmotic response (GO:0071474)	2.74046258
66	glycosphingolipid catabolic process (GO:0046479)	2.73500338
67	seminiferous tubule development (GO:0072520)	2.73085374
68	positive regulation of gamma-delta T cell activation (GO:0046645)	2.71838231
69	T cell migration (GO:0072678)	2.66137468
70	regulation of penile erection (GO:0060405)	2.65185518
71	mast cell activation (GO:0045576)	2.65024831
72	peptidyl-arginine methylation (GO:0018216)	2.64570398
73	peptidyl-arginine N-methylation (GO:0035246)	2.64570398
74	response to exogenous dsRNA (GO:0043330)	2.59940466
75	GDP-mannose metabolic process (GO:0019673)	2.58657465
76	DNA strand renaturation (GO:0000733)	2.58548014
77	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.58017452
78	valine metabolic process (GO:0006573)	2.57622795
79	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.56892186
80	B cell receptor signaling pathway (GO:0050853)	2.56417416
81	positive regulation of antigen processing and presentation (GO:0002579)	2.55113720
82	branched-chain amino acid catabolic process (GO:0009083)	2.54655775
83	positive regulation of protein kinase C signaling (GO:0090037)	2.54542188
84	cellular response to dsRNA (GO:0071359)	2.50560551
85	actin nucleation (GO:0045010)	2.50432410
86	histone H3-K9 methylation (GO:0051567)	2.50223421
87	positive regulation of erythrocyte differentiation (GO:0045648)	2.49450408
88	purine-containing compound salvage (GO:0043101)	2.49435807
89	T cell selection (GO:0045058)	2.49044296
90	axoneme assembly (GO:0035082)	2.44594655
91	histone H3-K36 demethylation (GO:0070544)	2.44188093
92	positive regulation of megakaryocyte differentiation (GO:0045654)	2.43802767
93	glycolipid catabolic process (GO:0019377)	2.41466550
94	branched-chain amino acid metabolic process (GO:0009081)	2.40153491
95	B cell mediated immunity (GO:0019724)	2.39105410
96	hyaluronan catabolic process (GO:0030214)	2.38354974
97	aggressive behavior (GO:0002118)	2.37440292
98	glutathione biosynthetic process (GO:0006750)	2.36731253
99	nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)	2.36421431
100	viral mRNA export from host cell nucleus (GO:0046784)	2.33181485

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.16236960
2	VDR_21846776_ChIP-Seq_THP-1_Human	3.38692618
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.02394686
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.96065811
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.84734521
6	* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.51512469
7	MYC_22102868_ChIP-Seq_BL_Human	2.49155653
8	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.29790674
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.27976285
10	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.23573577
11	VDR_24763502_ChIP-Seq_THP-1_Human	2.16042157
12	SCL_19346495_ChIP-Seq_HPC-7_Human	2.15521118
13	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	2.13978335
14	CIITA_25753668_ChIP-Seq_RAJI_Human	1.99857652
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.92821885
16	UTX_26944678_Chip-Seq_JUKART_Human	1.91084598
17	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.89801264
18	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.88092385
19	BCL6_27268052_Chip-Seq_Bcells_Human	1.86034124
20	MAF_26560356_Chip-Seq_TH1_Human	1.85266435
21	P68_20966046_ChIP-Seq_HELA_Human	1.83363381
22	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.81670964
23	LXR_22292898_ChIP-Seq_THP-1_Human	1.76587029
24	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.76048703
25	MAF_26560356_Chip-Seq_TH2_Human	1.75802346
26	MYB_26560356_Chip-Seq_TH2_Human	1.74693147
27	BCOR_27268052_Chip-Seq_Bcells_Human	1.74678010
28	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.74200501
29	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.74075743
30	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.72528386
31	SPI1_23547873_ChIP-Seq_NB4_Human	1.70866477
32	XRN2_22483619_ChIP-Seq_HELA_Human	1.70311416
33	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.69928612
34	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.63805831
35	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.60289775
36	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.56951673
37	E2F1_20622854_ChIP-Seq_HELA_Human	1.55289675
38	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.53935651
39	PHF8_20622854_ChIP-Seq_HELA_Human	1.50814375
40	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.47406889
41	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.46929461
42	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.45772692
43	TCF7_22412390_ChIP-Seq_EML_Mouse	1.44646247
44	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.44376217
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.44201788
46	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.42569641
47	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.41842737
48	FOXP3_21729870_ChIP-Seq_TREG_Human	1.41774181
49	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.41339153
50	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.38559309
51	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.38323869
52	MYB_26560356_Chip-Seq_TH1_Human	1.36993708
53	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.36817620
54	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.34152069
55	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.34069147
56	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.33812929
57	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.33646295
58	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.33392287
59	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.33273474
60	KDM2B_26808549_Chip-Seq_DND41_Human	1.32420528
61	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31557101
62	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.31483609
63	ZNF263_19887448_ChIP-Seq_K562_Human	1.30714037
64	KDM5A_27292631_Chip-Seq_BREAST_Human	1.30638421
65	VDR_23849224_ChIP-Seq_CD4+_Human	1.30445980
66	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.29546510
67	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.29508312
68	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.28268488
69	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.27543078
70	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.27247192
71	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.26955011
72	SMC4_20622854_ChIP-Seq_HELA_Human	1.25487351
73	NCOR1_26117541_ChIP-Seq_K562_Human	1.24167301
74	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.23346662
75	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.23208233
76	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.22660313
77	P300_27268052_Chip-Seq_Bcells_Human	1.21888606
78	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.21380742
79	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.21314590
80	CTCF_21964334_Chip-Seq_Bcells_Human	1.21287816
81	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.20492725
82	SPI1_23127762_ChIP-Seq_K562_Human	1.19746456
83	GATA3_27048872_Chip-Seq_THYMUS_Human	1.18992802
84	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.18981547
85	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.17096972
86	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.16931723
87	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.15836060
88	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.15737582
89	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.12512092
90	GATA1_19941826_ChIP-Seq_K562_Human	1.12136277
91	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.11927860
92	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.11330496
93	RUNX_20019798_ChIP-Seq_JUKART_Human	1.10284408
94	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.09613061
95	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.09255906
96	SPI1_20517297_ChIP-Seq_HL60_Human	1.08814019
97	GATA1_22025678_ChIP-Seq_K562_Human	1.08197307
98	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.07921564
99	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.07235599
100	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.06542123

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	4.00098216
2	MP0003436_decreased_susceptibility_to	3.49801719
3	MP0005058_abnormal_lysosome_morphology	2.88969311
4	MP0005464_abnormal_platelet_physiology	2.87611987
5	MP0000372_irregular_coat_pigmentation	2.87396426
6	MP0003172_abnormal_lysosome_physiology	2.65295374
7	MP0009278_abnormal_bone_marrow	2.60613170
8	MP0002132_abnormal_respiratory_system	2.58578713
9	MP0001545_abnormal_hematopoietic_system	2.55083215
10	MP0005397_hematopoietic_system_phenotyp	2.55083215
11	MP0001986_abnormal_taste_sensitivity	2.47897783
12	MP0002396_abnormal_hematopoietic_system	2.38863553
13	MP0001835_abnormal_antigen_presentation	2.33178304
14	MP0005075_abnormal_melanosome_morpholog	2.10392835
15	MP0008260_abnormal_autophagy	2.06218640
16	MP0002148_abnormal_hypersensitivity_rea	2.04682293
17	MP0000465_gastrointestinal_hemorrhage	2.03634277
18	MP0002398_abnormal_bone_marrow	1.91625874
19	MP0003191_abnormal_cellular_cholesterol	1.88793053
20	MP0002419_abnormal_innate_immunity	1.87913702
21	MP0005025_abnormal_response_to	1.86069631
22	MP0002420_abnormal_adaptive_immunity	1.77771933
23	MP0004782_abnormal_surfactant_physiolog	1.75478450
24	MP0003763_abnormal_thymus_physiology	1.74206198
25	MP0002723_abnormal_immune_serum	1.73131381
26	MP0001819_abnormal_immune_cell	1.73012400
27	MP0005000_abnormal_immune_tolerance	1.72020839
28	MP0009697_abnormal_copulation	1.70000458
29	MP0000689_abnormal_spleen_morphology	1.64110594
30	MP0002452_abnormal_antigen_presenting	1.61947820
31	MP0003183_abnormal_peptide_metabolism	1.61499966
32	MP0002722_abnormal_immune_system	1.59156552
33	MP0001800_abnormal_humoral_immune	1.57431465
34	MP0000716_abnormal_immune_system	1.53987579
35	MP0002405_respiratory_system_inflammati	1.47299275
36	MP0004808_abnormal_hematopoietic_stem	1.46033301
37	MP0002429_abnormal_blood_cell	1.44592286
38	MP0005646_abnormal_pituitary_gland	1.42989842
39	MP0003806_abnormal_nucleotide_metabolis	1.40253467
40	MP0001790_abnormal_immune_system	1.38462565
41	MP0005387_immune_system_phenotype	1.38462565
42	MP0005409_darkened_coat_color	1.37352024
43	MP0010155_abnormal_intestine_physiology	1.36426761
44	MP0005220_abnormal_exocrine_pancreas	1.35946243
45	MP0003303_peritoneal_inflammation	1.34191366
46	MP0002019_abnormal_tumor_incidence	1.33690103
47	MP0005360_urolithiasis	1.30280693
48	MP0001853_heart_inflammation	1.23144090
49	MP0000703_abnormal_thymus_morphology	1.20824554
50	MP0008007_abnormal_cellular_replicative	1.19519981
51	MP0005410_abnormal_fertilization	1.18587381
52	MP0009765_abnormal_xenobiotic_induced	1.16651848
53	MP0009333_abnormal_splenocyte_physiolog	1.15797610
54	MP0003866_abnormal_defecation	1.15205709
55	MP0008469_abnormal_protein_level	1.14947144
56	MP0009764_decreased_sensitivity_to	1.12384256
57	MP0000685_abnormal_immune_system	1.09459117
58	MP0006036_abnormal_mitochondrial_physio	1.07278169
59	MP0001533_abnormal_skeleton_physiology	1.05955501
60	MP0004185_abnormal_adipocyte_glucose	1.02668386
61	MP0000013_abnormal_adipose_tissue	1.01164033
62	MP0008058_abnormal_DNA_repair	1.00796980
63	MP0003656_abnormal_erythrocyte_physiolo	1.00392302
64	MP0005365_abnormal_bile_salt	0.96208264
65	MP0000681_abnormal_thyroid_gland	0.95915946
66	MP0005174_abnormal_tail_pigmentation	0.95852959
67	MP0009785_altered_susceptibility_to	0.95498604
68	MP0009763_increased_sensitivity_to	0.94583846
69	MP0001873_stomach_inflammation	0.92672626
70	MP0006054_spinal_hemorrhage	0.91321167
71	MP0004947_skin_inflammation	0.91116278
72	MP0000358_abnormal_cell_content/	0.88382071
73	MP0001845_abnormal_inflammatory_respons	0.88310806
74	MP0008995_early_reproductive_senescence	0.86643795
75	MP0005330_cardiomyopathy	0.84126714
76	MP0005377_hearing/vestibular/ear_phenot	0.83154429
77	MP0003878_abnormal_ear_physiology	0.83154429
78	MP0004147_increased_porphyrin_level	0.82464401
79	MP0000383_abnormal_hair_follicle	0.81318936
80	MP0003718_maternal_effect	0.80906255
81	MP0009384_cardiac_valve_regurgitation	0.80251789
82	MP0000015_abnormal_ear_pigmentation	0.79436059
83	MP0002160_abnormal_reproductive_system	0.79193304
84	MP0002249_abnormal_larynx_morphology	0.79097545
85	MP0009379_abnormal_foot_pigmentation	0.79018885
86	MP0000598_abnormal_liver_morphology	0.77289529
87	MP0008873_increased_physiological_sensi	0.76578686
88	MP0001764_abnormal_homeostasis	0.75687502
89	MP0003300_gastrointestinal_ulcer	0.75270993
90	MP0006292_abnormal_olfactory_placode	0.75229124
91	MP0005171_absent_coat_pigmentation	0.72180588
92	MP0002282_abnormal_trachea_morphology	0.71080152
93	MP0000490_abnormal_crypts_of	0.70360053
94	MP0000858_altered_metastatic_potential	0.70240636
95	MP0005671_abnormal_response_to	0.69611710
96	MP0002933_joint_inflammation	0.68760194
97	MP0003724_increased_susceptibility_to	0.65691622
98	MP0006035_abnormal_mitochondrial_morpho	0.64714358
99	MP0008961_abnormal_basal_metabolism	0.64360835
100	MP0009642_abnormal_blood_homeostasis	0.62539269

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dyschromatopsia (HP:0007641)	5.07889259
2	Elevated erythrocyte sedimentation rate (HP:0003565)	4.83902157
3	Prolonged bleeding time (HP:0003010)	4.59375386
4	Attenuation of retinal blood vessels (HP:0007843)	4.04943229
5	Panhypogammaglobulinemia (HP:0003139)	3.96398704
6	Decreased central vision (HP:0007663)	3.25613236
7	Epistaxis (HP:0000421)	3.09705871
8	Seborrheic dermatitis (HP:0001051)	3.04813942
9	Myositis (HP:0100614)	2.98848586
10	Recurrent fungal infections (HP:0002841)	2.95637821
11	Recurrent cutaneous fungal infections (HP:0011370)	2.84853278
12	Chronic mucocutaneous candidiasis (HP:0002728)	2.84853278
13	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.83660589
14	Microvesicular hepatic steatosis (HP:0001414)	2.82746727
15	Muscle stiffness (HP:0003552)	2.80846039
16	Chronic obstructive pulmonary disease (HP:0006510)	2.71339548
17	Obstructive lung disease (HP:0006536)	2.71339548
18	Abnormal protein N-linked glycosylation (HP:0012347)	2.70727897
19	Abnormal protein glycosylation (HP:0012346)	2.70727897
20	Abnormal glycosylation (HP:0012345)	2.70727897
21	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.70727897
22	Petechiae (HP:0000967)	2.67330334
23	Hypertensive crisis (HP:0100735)	2.59537077
24	Abnormality of polysaccharide metabolism (HP:0011012)	2.59081171
25	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.59081171
26	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.59081171
27	Brushfield spots (HP:0001088)	2.58929373
28	Abnormality of the prostate (HP:0008775)	2.55293792
29	Hemorrhage of the eye (HP:0011885)	2.54637150
30	Aplastic anemia (HP:0001915)	2.49730925
31	Acute lymphatic leukemia (HP:0006721)	2.48901650
32	Basal cell carcinoma (HP:0002671)	2.48837428
33	Thrombocytosis (HP:0001894)	2.46472730
34	Agammaglobulinemia (HP:0004432)	2.44769054
35	Testicular atrophy (HP:0000029)	2.42474138
36	Dysautonomia (HP:0002459)	2.42005190
37	Dicarboxylic aciduria (HP:0003215)	2.41252204
38	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.41252204
39	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.40628522
40	Granulocytopenia (HP:0001913)	2.39133723
41	Abnormality of fatty-acid metabolism (HP:0004359)	2.37399751
42	Progressive microcephaly (HP:0000253)	2.34415215
43	Spastic paraparesis (HP:0002313)	2.32660500
44	Increased IgE level (HP:0003212)	2.31610573
45	3-Methylglutaconic aciduria (HP:0003535)	2.31118623
46	Abnormality of B cell number (HP:0010975)	2.30998934
47	Joint stiffness (HP:0001387)	2.30928168
48	Joint hemorrhage (HP:0005261)	2.30399016
49	Mucopolysacchariduria (HP:0008155)	2.30177046
50	Urinary glycosaminoglycan excretion (HP:0003541)	2.30177046
51	Dysostosis multiplex (HP:0000943)	2.28177732
52	Type I transferrin isoform profile (HP:0003642)	2.27544990
53	Pustule (HP:0200039)	2.21459970
54	Chest pain (HP:0100749)	2.20471631
55	Abnormality of glycolipid metabolism (HP:0010969)	2.19065667
56	Abnormality of liposaccharide metabolism (HP:0010968)	2.19065667
57	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.19065667
58	Increased serum ferritin (HP:0003281)	2.19036293
59	Bile duct proliferation (HP:0001408)	2.18361381
60	Abnormal biliary tract physiology (HP:0012439)	2.18361381
61	Chronic otitis media (HP:0000389)	2.17245702
62	Mesangial abnormality (HP:0001966)	2.15753319
63	Abnormality of macular pigmentation (HP:0008002)	2.15321320
64	Recurrent viral infections (HP:0004429)	2.14931529
65	Prostate neoplasm (HP:0100787)	2.14887547
66	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.13443242
67	Increased muscle lipid content (HP:0009058)	2.11415178
68	Thin bony cortex (HP:0002753)	2.10140005
69	Bony spicule pigmentary retinopathy (HP:0007737)	2.09526045
70	Abnormality of iron homeostasis (HP:0011031)	2.08016829
71	Prolonged partial thromboplastin time (HP:0003645)	2.06205862
72	Failure to thrive in infancy (HP:0001531)	2.05236059
73	Hepatosplenomegaly (HP:0001433)	2.04451267
74	Cellulitis (HP:0100658)	2.02053703
75	B lymphocytopenia (HP:0010976)	2.01641162
76	Truncus arteriosus (HP:0001660)	2.00747982
77	Progressive muscle weakness (HP:0003323)	2.00713351
78	Abnormality of male internal genitalia (HP:0000022)	1.97705706
79	Thoracic kyphosis (HP:0002942)	1.91820006
80	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.91630505
81	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.91422355
82	Abnormality of the peritoneum (HP:0002585)	1.89468776
83	Vacuolated lymphocytes (HP:0001922)	1.88312048
84	Meningitis (HP:0001287)	1.88142842
85	Annular pancreas (HP:0001734)	1.88092786
86	Encephalitis (HP:0002383)	1.87970416
87	Autoimmune hemolytic anemia (HP:0001890)	1.87022298
88	Abnormality of the costochondral junction (HP:0000919)	1.86806559
89	Hepatocellular necrosis (HP:0001404)	1.85283298
90	Cheilitis (HP:0100825)	1.85217978
91	Episodic fever (HP:0001954)	1.84953637
92	Epiphyseal stippling (HP:0010655)	1.84558118
93	Recurrent skin infections (HP:0001581)	1.83933878
94	Progressive external ophthalmoplegia (HP:0000590)	1.83613673
95	Abnormality of transition element cation homeostasis (HP:0011030)	1.83202567
96	Delayed epiphyseal ossification (HP:0002663)	1.82883964
97	Fatigue (HP:0012378)	1.82748544
98	J-shaped sella turcica (HP:0002680)	1.82512651
99	Abnormal epiphyseal ossification (HP:0010656)	1.82156531
100	Abnormal enzyme/coenzyme activity (HP:0012379)	1.79162593

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	4.30742001
2	VRK2	3.27528347
3	MAP2K3	3.19213413
4	MAP4K1	3.15441184
5	SRPK1	3.01306503
6	BCKDK	2.97037581
7	KIT	2.45067172
8	MAPK15	2.43427427
9	TBK1	2.39910691
10	TAOK3	2.25762668
11	FLT3	2.18694773
12	TESK2	2.15776360
13	TNK2	2.06795048
14	SMG1	1.95575997
15	PRPF4B	1.93970082
16	FES	1.88726292
17	GRK6	1.84293759
18	SCYL2	1.76349221
19	NUAK1	1.66660372
20	CSF1R	1.58148175
21	IRAK2	1.57434778
22	PIM2	1.56929674
23	ZAP70	1.54006994
24	MAP3K14	1.52781130
25	MAP3K11	1.52526459
26	IKBKB	1.51810233
27	STK16	1.48296593
28	BTK	1.47078739
29	MAP2K2	1.39848951
30	TRIB3	1.35509245
31	SYK	1.33709375
32	MAP2K6	1.31936993
33	TEC	1.21488655
34	IRAK1	1.14521849
35	JAK3	1.12578977
36	TAOK2	1.10255343
37	LRRK2	1.08487571
38	ITK	1.03105938
39	PRKD2	1.00816327
40	IKBKE	0.99920194
41	TXK	0.97515544
42	HCK	0.97306989
43	BLK	0.88742847
44	CCNB1	0.86840913
45	VRK1	0.83597291
46	CDK9	0.81580463
47	EIF2AK2	0.81172950
48	LCK	0.79346124
49	MAP3K6	0.78266572
50	RPS6KC1	0.78157946
51	RPS6KL1	0.78157946
52	BMX	0.77239959
53	WNK4	0.76746461
54	PRKCQ	0.74176169
55	PKN2	0.73593460
56	EPHB1	0.73347745
57	ATR	0.72903258
58	RPS6KA6	0.72864639
59	MAP3K13	0.72460384
60	RPS6KA2	0.67290307
61	NME2	0.67280294
62	SIK3	0.66556038
63	KDR	0.66536089
64	RPS6KA5	0.65659879
65	SIK1	0.63747478
66	MAPK11	0.62913327
67	MATK	0.59346746
68	RIPK4	0.58963457
69	MAPK7	0.58732837
70	MAP2K4	0.58047956
71	LYN	0.56869122
72	CDK7	0.56005204
73	MAPK3	0.55841726
74	CDK12	0.54497696
75	TYK2	0.48639439
76	ADRBK1	0.48399687
77	SIK2	0.47860928
78	RPS6KA1	0.47739423
79	MARK2	0.47613819
80	CHUK	0.46740432
81	DYRK1B	0.46658106
82	PRKCI	0.46597201
83	MAP3K1	0.46530742
84	PDPK1	0.44604654
85	RAF1	0.44345900
86	IRAK4	0.44196308
87	CLK1	0.43719186
88	CDK4	0.41497903
89	CAMKK1	0.38831679
90	MTOR	0.38265979
91	PKN1	0.37522759
92	CSNK1G3	0.35636080
93	PDK1	0.34154862
94	MAPK4	0.34058460
95	ARAF	0.33855956
96	BMPR1B	0.33657702
97	PASK	0.32553847
98	MAP3K7	0.31863062
99	MARK3	0.31060248
100	HIPK2	0.30331694

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other glycan degradation_Homo sapiens_hsa00511	5.62916193
2	Glycosaminoglycan degradation_Homo sapiens_hsa00531	4.04886797
3	Allograft rejection_Homo sapiens_hsa05330	2.91477038
4	Asthma_Homo sapiens_hsa05310	2.85752098
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.65876425
6	Leishmaniasis_Homo sapiens_hsa05140	2.32434205
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.32383416
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.31191488
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.27595927
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.09578874
11	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.97411962
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.93307723
13	Base excision repair_Homo sapiens_hsa03410	1.89125642
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.87482770
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.76552992
16	Herpes simplex infection_Homo sapiens_hsa05168	1.75204421
17	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.74597391
18	Sulfur relay system_Homo sapiens_hsa04122	1.60623449
19	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.56656091
20	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.56631253
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.47591203
22	Sphingolipid metabolism_Homo sapiens_hsa00600	1.44004310
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.41880759
24	Ribosome_Homo sapiens_hsa03010	1.40073345
25	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.37994337
26	RNA polymerase_Homo sapiens_hsa03020	1.34486622
27	Acute myeloid leukemia_Homo sapiens_hsa05221	1.32295378
28	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.22352041
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.21469552
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.21222088
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.16082132
32	Peroxisome_Homo sapiens_hsa04146	1.13020692
33	Influenza A_Homo sapiens_hsa05164	1.09889001
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06495146
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.06355137
36	Butanoate metabolism_Homo sapiens_hsa00650	1.06061350
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.04482613
38	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.04088457
39	Spliceosome_Homo sapiens_hsa03040	0.98437000
40	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.94553338
41	Platelet activation_Homo sapiens_hsa04611	0.91972405
42	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.91440579
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89877501
44	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.88368078
45	Viral myocarditis_Homo sapiens_hsa05416	0.87845798
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87435812
47	Pertussis_Homo sapiens_hsa05133	0.86623391
48	RNA transport_Homo sapiens_hsa03013	0.86027926
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85603759
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84769638
51	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.84543296
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82626486
53	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.82510627
54	Tuberculosis_Homo sapiens_hsa05152	0.81675959
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81154413
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.79943578
57	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.78168729
58	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.76119581
59	Lysine degradation_Homo sapiens_hsa00310	0.76025928
60	Hepatitis C_Homo sapiens_hsa05160	0.71838789
61	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.70592920
62	Lysosome_Homo sapiens_hsa04142	0.70049951
63	Shigellosis_Homo sapiens_hsa05131	0.69736098
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.68393947
65	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67776681
66	Rheumatoid arthritis_Homo sapiens_hsa05323	0.67190088
67	Fanconi anemia pathway_Homo sapiens_hsa03460	0.66911188
68	Toxoplasmosis_Homo sapiens_hsa05145	0.66723814
69	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.64765022
70	Fatty acid degradation_Homo sapiens_hsa00071	0.64154778
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.63273279
72	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.61313208
73	Glutathione metabolism_Homo sapiens_hsa00480	0.60425271
74	RNA degradation_Homo sapiens_hsa03018	0.59010622
75	Measles_Homo sapiens_hsa05162	0.57847156
76	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.56400509
77	Homologous recombination_Homo sapiens_hsa03440	0.53458582
78	Legionellosis_Homo sapiens_hsa05134	0.51973757
79	Pentose phosphate pathway_Homo sapiens_hsa00030	0.51654895
80	Osteoclast differentiation_Homo sapiens_hsa04380	0.50241378
81	Carbon metabolism_Homo sapiens_hsa01200	0.48287790
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.47745299
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47611071
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45463446
85	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.45384455
86	Purine metabolism_Homo sapiens_hsa00230	0.43199602
87	Non-homologous end-joining_Homo sapiens_hsa03450	0.42008204
88	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.41520451
89	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.41456847
90	mRNA surveillance pathway_Homo sapiens_hsa03015	0.41092965
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38428862
92	HTLV-I infection_Homo sapiens_hsa05166	0.37263955
93	ABC transporters_Homo sapiens_hsa02010	0.36904323
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36902174
95	African trypanosomiasis_Homo sapiens_hsa05143	0.36810791
96	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.35457108
97	DNA replication_Homo sapiens_hsa03030	0.32872066
98	Apoptosis_Homo sapiens_hsa04210	0.32418561
99	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.31720666
100	Propanoate metabolism_Homo sapiens_hsa00640	0.31415640

TRIM74

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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