TRIM77

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.15261430
2regulation of meiosis I (GO:0060631)8.96351370
3piRNA metabolic process (GO:0034587)8.79576994
4meiotic cell cycle (GO:0051321)8.20648616
5retinal cone cell development (GO:0046549)7.46042908
6positive regulation of histone H3-K4 methylation (GO:0051571)7.05327381
7regulation of histone H3-K9 methylation (GO:0051570)7.00955467
8regulation of acrosome reaction (GO:0060046)6.81482380
9DNA methylation involved in gamete generation (GO:0043046)6.73896222
10regulation of cell maturation (GO:1903429)6.46785236
11female gamete generation (GO:0007292)6.14885749
12negative regulation of histone methylation (GO:0031061)5.91948096
13oocyte development (GO:0048599)5.86077501
14glycine transport (GO:0015816)5.85929187
15positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.69622883
16positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.69622883
17positive regulation of mitotic sister chromatid separation (GO:1901970)5.69622883
18multicellular organism reproduction (GO:0032504)5.54987389
19regulation of steroid hormone secretion (GO:2000831)5.51888345
20positive regulation of gastrulation (GO:2000543)5.49429757
21gene silencing by RNA (GO:0031047)5.46859554
22centriole replication (GO:0007099)5.26701855
23negative regulation of reproductive process (GO:2000242)5.08358721
24protein localization to kinetochore (GO:0034501)5.03154017
25mitotic chromosome condensation (GO:0007076)5.00214390
26protein localization to chromosome, centromeric region (GO:0071459)4.95007082
27positive regulation of chromosome segregation (GO:0051984)4.93362767
28mitotic metaphase plate congression (GO:0007080)4.85704643
29primitive streak formation (GO:0090009)4.77291974
30establishment of chromosome localization (GO:0051303)4.70073195
31regulation of meiosis (GO:0040020)4.55407548
32synapsis (GO:0007129)4.46033032
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.45064607
34synaptonemal complex assembly (GO:0007130)4.32532824
35positive regulation of histone methylation (GO:0031062)4.28010740
36protein kinase C signaling (GO:0070528)4.26920049
37relaxation of smooth muscle (GO:0044557)4.22642853
38regulation of steroid hormone biosynthetic process (GO:0090030)4.19452702
39L-amino acid import (GO:0043092)4.18139890
40regulation of histone H3-K4 methylation (GO:0051569)4.09691213
41phosphorelay signal transduction system (GO:0000160)4.09046716
42protein localization to chromosome (GO:0034502)4.01841974
43chromosome organization involved in meiosis (GO:0070192)4.01400394
44regulation of spindle organization (GO:0090224)4.00189699
45male meiosis I (GO:0007141)3.97706809
46male meiosis (GO:0007140)3.94252487
47metaphase plate congression (GO:0051310)3.92597161
48negative regulation of execution phase of apoptosis (GO:1900118)3.89864057
49positive regulation of humoral immune response (GO:0002922)3.88231166
50oogenesis (GO:0048477)3.84717813
51nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.84087340
52synaptonemal complex organization (GO:0070193)3.83260089
53attachment of spindle microtubules to kinetochore (GO:0008608)3.83093408
54DNA alkylation (GO:0006305)3.75288982
55DNA methylation (GO:0006306)3.75288982
56negative regulation of cAMP-mediated signaling (GO:0043951)3.73563470
57regulation of meiotic cell cycle (GO:0051445)3.72401130
58CENP-A containing nucleosome assembly (GO:0034080)3.70240185
59meiotic nuclear division (GO:0007126)3.69109563
60somite rostral/caudal axis specification (GO:0032525)3.68134168
61labyrinthine layer development (GO:0060711)3.66235882
62regulation of histone methylation (GO:0031060)3.65745529
63phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.63767488
64negative regulation of hormone biosynthetic process (GO:0032353)3.63568265
65gene silencing (GO:0016458)3.63209609
66meiotic cell cycle process (GO:1903046)3.61957910
67neuron fate determination (GO:0048664)3.61289044
68meiosis I (GO:0007127)3.60260132
69DNA damage induced protein phosphorylation (GO:0006975)3.58989343
70reproduction (GO:0000003)3.58614182
71centriole assembly (GO:0098534)3.56616771
72negative regulation of hormone metabolic process (GO:0032351)3.48404496
73regulation of spindle checkpoint (GO:0090231)3.42340962
74fertilization (GO:0009566)3.41982731
75positive regulation of reproductive process (GO:2000243)3.38920484
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.37138572
77positive regulation of uterine smooth muscle contraction (GO:0070474)3.34736708
78chromatin remodeling at centromere (GO:0031055)3.34658154
79translesion synthesis (GO:0019985)3.34619629
80negative regulation of histone modification (GO:0031057)3.32210834
81histone H3-K9 demethylation (GO:0033169)3.27689274
82DNA replication-dependent nucleosome assembly (GO:0006335)3.25259680
83DNA replication-dependent nucleosome organization (GO:0034723)3.25259680
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23099342
85histone-serine phosphorylation (GO:0035404)3.21582760
86regulation of corticosteroid hormone secretion (GO:2000846)3.17620371
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17345551
88positive regulation of meiosis (GO:0045836)3.12896131
89regulation of reproductive process (GO:2000241)3.11392494
90regulation of chromatin silencing (GO:0031935)3.06330256
91citrulline biosynthetic process (GO:0019240)3.03739827
92dopamine biosynthetic process (GO:0042416)3.01436061
93histone phosphorylation (GO:0016572)2.99460955
94positive regulation of hormone biosynthetic process (GO:0046886)2.98368851
95pyrimidine-containing compound transmembrane transport (GO:0072531)2.97374427
96mitotic G2/M transition checkpoint (GO:0044818)2.97158272
97oocyte maturation (GO:0001556)2.96422412
98negative regulation of chromatin modification (GO:1903309)2.94316925
99centrosome duplication (GO:0051298)2.94171008
100regulation of DNA methylation (GO:0044030)10.7746062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.35486863
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.34857462
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.81529912
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.25632918
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.24554208
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.24554208
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.24554208
8E2F7_22180533_ChIP-Seq_HELA_Human3.22074943
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.19891512
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.92774869
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.54370155
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54055571
13GBX2_23144817_ChIP-Seq_PC3_Human2.10448932
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.02127381
15EZH2_22144423_ChIP-Seq_EOC_Human13.5163243
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96650777
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.96339433
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85175224
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76611728
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.71973248
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71395709
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.67682321
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64094026
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54649604
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54040078
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53628739
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.51028076
28IRF1_19129219_ChIP-ChIP_H3396_Human1.50319092
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34257639
30TCF4_23295773_ChIP-Seq_U87_Human1.29847729
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.28580099
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28107907
33CBP_20019798_ChIP-Seq_JUKART_Human1.27062569
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27062569
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25717751
36AR_21909140_ChIP-Seq_LNCAP_Human1.22713046
37PRDM14_20953172_ChIP-Seq_ESCs_Human1.21115355
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15633316
39AR_25329375_ChIP-Seq_VCAP_Human1.12207284
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10008382
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07654804
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07654804
43SMAD4_21799915_ChIP-Seq_A2780_Human1.07314749
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07124751
45LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04842473
46SMAD4_21741376_ChIP-Seq_EPCs_Human1.04646875
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04570165
48STAT3_23295773_ChIP-Seq_U87_Human1.02175377
49EWS_26573619_Chip-Seq_HEK293_Human0.99294150
50RUNX2_22187159_ChIP-Seq_PCA_Human0.98132407
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97945469
52GF1_26923725_Chip-Seq_HPCs_Mouse0.95779134
53HTT_18923047_ChIP-ChIP_STHdh_Human0.95374730
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93683315
55NANOG_20526341_ChIP-Seq_ESCs_Human0.92781591
56P300_19829295_ChIP-Seq_ESCs_Human0.91768321
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90931986
58CBP_21632823_ChIP-Seq_H3396_Human0.90918987
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90130154
60LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88315665
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87704199
62TP53_16413492_ChIP-PET_HCT116_Human0.87527130
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87118951
64FOXH1_21741376_ChIP-Seq_EPCs_Human0.86855193
65TAL1_26923725_Chip-Seq_HPCs_Mouse0.86765888
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86755983
67AHR_22903824_ChIP-Seq_MCF-7_Human0.86192005
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83355257
69ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83343111
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83075164
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82569492
72VDR_22108803_ChIP-Seq_LS180_Human0.80235237
73SMRT_27268052_Chip-Seq_Bcells_Human0.79662540
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.77603232
75SMAD3_21741376_ChIP-Seq_EPCs_Human0.77480392
76NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77327176
77RNF2_27304074_Chip-Seq_NSC_Mouse0.73846151
78SALL4_22934838_ChIP-ChIP_CD34+_Human0.73658716
79CTBP2_25329375_ChIP-Seq_LNCAP_Human0.73339149
80BMI1_23680149_ChIP-Seq_NPCS_Mouse0.73102756
81REST_21632747_ChIP-Seq_MESCs_Mouse0.72759689
82GATA1_19941827_ChIP-Seq_MEL86_Mouse0.71738632
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71504569
84SALL1_21062744_ChIP-ChIP_HESCs_Human0.70226636
85TP53_22573176_ChIP-Seq_HFKS_Human0.69753200
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.68609018
87EZH2_27304074_Chip-Seq_ESCs_Mouse0.67571767
88BCAT_22108803_ChIP-Seq_LS180_Human0.67433328
89ZNF274_21170338_ChIP-Seq_K562_Hela0.67387734
90CREB1_15753290_ChIP-ChIP_HEK293T_Human0.67073495
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.66702344
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.66609503
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.66402729
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65313354
95DROSHA_22980978_ChIP-Seq_HELA_Human0.64602139
96SOX2_21211035_ChIP-Seq_LN229_Gbm0.64343364
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.63571865
98KLF4_19829295_ChIP-Seq_ESCs_Human0.63476100
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.63124136
100KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.62818131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.92716658
2MP0008877_abnormal_DNA_methylation4.98014742
3MP0006292_abnormal_olfactory_placode4.85228193
4MP0008789_abnormal_olfactory_epithelium4.81030147
5MP0005499_abnormal_olfactory_system4.18495894
6MP0005394_taste/olfaction_phenotype4.18495894
7MP0002139_abnormal_hepatobiliary_system3.21534420
8MP0003890_abnormal_embryonic-extraembry3.10341507
9MP0005395_other_phenotype3.09844008
10MP0008057_abnormal_DNA_replication2.97228741
11MP0010030_abnormal_orbit_morphology2.81342625
12MP0002138_abnormal_hepatobiliary_system2.77634217
13MP0003693_abnormal_embryo_hatching2.77388719
14MP0002234_abnormal_pharynx_morphology2.60402612
15MP0010234_abnormal_vibrissa_follicle2.52242708
16MP0000566_synostosis2.49152260
17MP0005360_urolithiasis2.40332776
18MP0003699_abnormal_female_reproductive2.33577221
19MP0003879_abnormal_hair_cell2.15153740
20MP0001929_abnormal_gametogenesis2.12035509
21MP0002210_abnormal_sex_determination2.10721194
22MP0003183_abnormal_peptide_metabolism2.09248284
23MP0003077_abnormal_cell_cycle1.96376889
24MP0008058_abnormal_DNA_repair1.85037459
25MP0010094_abnormal_chromosome_stability1.84304915
26MP0005410_abnormal_fertilization1.84212137
27MP0003950_abnormal_plasma_membrane1.73695974
28MP0000653_abnormal_sex_gland1.66250566
29MP0003121_genomic_imprinting1.60625686
30MP0002160_abnormal_reproductive_system1.60024688
31MP0002161_abnormal_fertility/fecundity1.58707306
32MP0001293_anophthalmia1.41748754
33MP0003111_abnormal_nucleus_morphology1.41378711
34MP0001145_abnormal_male_reproductive1.37798286
35MP0010307_abnormal_tumor_latency1.36883538
36MP0000631_abnormal_neuroendocrine_gland1.35020937
37MP0005646_abnormal_pituitary_gland1.32847523
38MP0001984_abnormal_olfaction1.28491132
39MP0000762_abnormal_tongue_morphology1.20742191
40MP0009840_abnormal_foam_cell1.20702281
41MP0000427_abnormal_hair_cycle1.17710256
42MP0001119_abnormal_female_reproductive1.17585795
43MP0005647_abnormal_sex_gland1.16569492
44MP0003698_abnormal_male_reproductive1.15950326
45MP0003252_abnormal_bile_duct1.15729850
46MP0008932_abnormal_embryonic_tissue1.15139492
47MP0002233_abnormal_nose_morphology1.14643694
48MP0001730_embryonic_growth_arrest1.13599480
49MP0005085_abnormal_gallbladder_physiolo1.05778075
50MP0003119_abnormal_digestive_system1.05618545
51MP0002272_abnormal_nervous_system1.03215004
52MP0005389_reproductive_system_phenotype1.02281062
53MP0001986_abnormal_taste_sensitivity0.94933551
54MP0010368_abnormal_lymphatic_system0.94393416
55MP0005551_abnormal_eye_electrophysiolog0.94331183
56MP0004142_abnormal_muscle_tone0.91224266
57MP0003136_yellow_coat_color0.91142284
58MP0000049_abnormal_middle_ear0.86800563
59MP0006276_abnormal_autonomic_nervous0.85455799
60MP0003868_abnormal_feces_composition0.80237875
61MP0001664_abnormal_digestion0.79630762
62MP0005380_embryogenesis_phenotype0.76563761
63MP0001672_abnormal_embryogenesis/_devel0.76563761
64MP0010678_abnormal_skin_adnexa0.75729260
65MP0000350_abnormal_cell_proliferation0.74770700
66MP0001666_abnormal_nutrient_absorption0.73432972
67MP0001324_abnormal_eye_pigmentation0.68854751
68MP0009379_abnormal_foot_pigmentation0.65883369
69MP0002751_abnormal_autonomic_nervous0.63643173
70MP0001502_abnormal_circadian_rhythm0.62015957
71MP0000678_abnormal_parathyroid_gland0.61521135
72MP0002796_impaired_skin_barrier0.60171755
73MP0001963_abnormal_hearing_physiology0.59108621
74MP0000015_abnormal_ear_pigmentation0.51204067
75MP0004043_abnormal_pH_regulation0.50512207
76MP0004957_abnormal_blastocyst_morpholog0.49228439
77MP0002102_abnormal_ear_morphology0.49148999
78MP0002084_abnormal_developmental_patter0.48670850
79MP0000428_abnormal_craniofacial_morphol0.48618743
80MP0003941_abnormal_skin_development0.47886004
81MP0003935_abnormal_craniofacial_develop0.46029654
82MP0005501_abnormal_skin_physiology0.43067989
83MP0003755_abnormal_palate_morphology0.42976820
84MP0002127_abnormal_cardiovascular_syste0.40791993
85MP0005075_abnormal_melanosome_morpholog0.40196245
86MP0002089_abnormal_postnatal_growth/wei0.38957272
87MP0002638_abnormal_pupillary_reflex0.38552051
88MP0002735_abnormal_chemical_nociception0.38524272
89MP0005503_abnormal_tendon_morphology0.38351162
90MP0003195_calcinosis0.37999015
91MP0002928_abnormal_bile_duct0.37852456
92MP0000026_abnormal_inner_ear0.37598646
93MP0003936_abnormal_reproductive_system0.36025760
94MP0002873_normal_phenotype0.34944529
95MP0002090_abnormal_vision0.34928935
96MP0002169_no_abnormal_phenotype0.34414806
97MP0001486_abnormal_startle_reflex0.33465940
98MP0002085_abnormal_embryonic_tissue0.32940456
99MP0003656_abnormal_erythrocyte_physiolo0.32743082
100MP0005319_abnormal_enzyme/_coenzyme0.31216060

Predicted human phenotypes

RankGene SetZ-score
1Supernumerary spleens (HP:0009799)6.76157656
2Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.57992471
3Abdominal situs inversus (HP:0003363)5.41792908
4Abnormality of abdominal situs (HP:0011620)5.41792908
5Facial hemangioma (HP:0000329)5.31329719
6Osteomalacia (HP:0002749)4.70400493
7Cholecystitis (HP:0001082)4.68153297
8Abnormal gallbladder physiology (HP:0012438)4.68153297
9Lip pit (HP:0100267)4.66766640
10Septo-optic dysplasia (HP:0100842)4.60571697
11Oligodactyly (hands) (HP:0001180)4.50514412
12Impulsivity (HP:0100710)4.49562997
13Hypoplasia of the fovea (HP:0007750)4.14484983
14Aplasia/Hypoplasia of the fovea (HP:0008060)4.14484983
15Hypophosphatemic rickets (HP:0004912)4.14002046
16Anterior segment dysgenesis (HP:0007700)3.96760430
17Median cleft lip (HP:0000161)3.83221977
18Absent septum pellucidum (HP:0001331)3.79482864
19Male infertility (HP:0003251)3.77117149
20Chromsome breakage (HP:0040012)3.76902962
21Azoospermia (HP:0000027)3.70928185
22Papillary thyroid carcinoma (HP:0002895)3.69255960
23Abnormality of the labia minora (HP:0012880)3.63042395
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61099166
25Abnormality of the fovea (HP:0000493)3.54301661
26Short tibia (HP:0005736)3.54065437
27Enlarged penis (HP:0000040)3.53359015
28Gonadotropin excess (HP:0000837)3.40684605
29Capillary hemangiomas (HP:0005306)3.36066935
30Infertility (HP:0000789)3.31688428
31Wrist flexion contracture (HP:0001239)3.24692412
32Abnormality of the septum pellucidum (HP:0007375)3.20666014
33Aplasia/Hypoplasia of the tibia (HP:0005772)3.20378843
34Oligodactyly (HP:0012165)3.19266930
35Apathy (HP:0000741)3.17388674
36Malnutrition (HP:0004395)3.12144604
37Fair hair (HP:0002286)3.09102430
38Hypokinesia (HP:0002375)3.08282233
39Diminished motivation (HP:0000745)3.07235133
40Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.00984477
41Premature ovarian failure (HP:0008209)2.99196258
42Abnormal spermatogenesis (HP:0008669)2.77943963
43Lower limb hyperreflexia (HP:0002395)2.63369266
44Stillbirth (HP:0003826)2.58335341
45Aplasia/Hypoplasia of the macula (HP:0008059)2.56872159
46Maternal diabetes (HP:0009800)2.52733925
47Aplasia/Hypoplasia of the tongue (HP:0010295)2.52071528
48Truncal obesity (HP:0001956)2.46047027
49Bile duct proliferation (HP:0001408)2.41725366
50Abnormal biliary tract physiology (HP:0012439)2.41725366
51Muscle stiffness (HP:0003552)2.41532739
52Urethral obstruction (HP:0000796)2.40016858
53Metaphyseal irregularity (HP:0003025)2.39526668
54Spinal cord compression (HP:0002176)2.39292906
55Aplasia of the musculature (HP:0100854)2.38795577
56Aplasia/Hypoplasia affecting the retina (HP:0008061)2.35296944
57Congenital sensorineural hearing impairment (HP:0008527)2.33166120
58Ankle contracture (HP:0006466)2.32928151
59Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.30597548
60Optic nerve hypoplasia (HP:0000609)2.28870910
61Dysdiadochokinesis (HP:0002075)2.28303822
62Intrahepatic cholestasis (HP:0001406)2.23686278
63Posterior subcapsular cataract (HP:0007787)2.23231496
64Skin pits (HP:0100276)2.23188499
65Gaze-evoked nystagmus (HP:0000640)2.22558889
66Striae distensae (HP:0001065)2.22059357
67Abnormal ciliary motility (HP:0012262)2.20427604
68Generalized hypopigmentation of hair (HP:0011358)2.19680756
69Conjunctival telangiectasia (HP:0000524)2.19403737
70Nephroblastoma (Wilms tumor) (HP:0002667)2.14886435
71Abnormality of the phalanges of the hallux (HP:0010057)2.14488643
72Sensory axonal neuropathy (HP:0003390)2.13896014
73Limb hypertonia (HP:0002509)2.12038154
74Hip contracture (HP:0003273)2.09823507
75Proximal tubulopathy (HP:0000114)2.08854116
76Loss of speech (HP:0002371)2.06197564
77Abnormal lung lobation (HP:0002101)2.04775654
78Thyroid carcinoma (HP:0002890)2.03424382
79Embryonal renal neoplasm (HP:0011794)2.01900870
80Abnormality of chromosome stability (HP:0003220)2.01665553
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.00577189
82Myokymia (HP:0002411)2.00431563
83Bundle branch block (HP:0011710)1.99453085
84Generalized aminoaciduria (HP:0002909)1.97151059
85Bicornuate uterus (HP:0000813)1.96748063
86Abnormality of chromosome segregation (HP:0002916)1.96574903
87Anhidrosis (HP:0000970)1.94840816
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93546020
89Heterotopia (HP:0002282)1.92073096
90Microglossia (HP:0000171)1.84097352
91Shallow orbits (HP:0000586)1.79469834
92Abnormality of the preputium (HP:0100587)1.79363256
93Meckel diverticulum (HP:0002245)1.79242170
94Duodenal stenosis (HP:0100867)1.77375649
95Small intestinal stenosis (HP:0012848)1.77375649
96Abnormal respiratory motile cilium physiology (HP:0012261)1.76575144
97Increased circulating renin level (HP:0000848)1.76452162
98Abnormality of the ileum (HP:0001549)1.75691404
99Abnormality of calcium-phosphate metabolism (HP:0100530)1.75534460
100Abnormality of monocarboxylic acid metabolism (HP:0010996)1.72707491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.41440549
2MAP3K135.96467898
3ARAF5.79272104
4NEK63.31712099
5STK243.10496184
6TAOK33.03658161
7BRAF3.00925548
8TTK2.93082083
9MOS2.87133282
10CDK92.66111217
11AURKA2.26780404
12MET2.26207428
13CDC72.02497565
14RAF11.96817781
15KSR21.93962472
16CDK121.87541375
17PRKCI1.82132294
18NTRK21.78416229
19CDK71.44196902
20EIF2AK31.42260612
21TNIK1.41878330
22MELK1.35793574
23STK31.31138605
24PLK11.30712325
25NUAK11.24169058
26CDK81.23418225
27KSR11.18457630
28TRIM281.15064994
29NEK91.08063326
30ZAK1.02940139
31MAP3K80.99660245
32BUB10.96482842
33CDK190.94862087
34MAP3K40.93061721
35MST40.92145823
36PIM10.91923801
37NEK20.88188747
38CSNK1G10.87491590
39TIE10.85723209
40MARK30.81715058
41PLK30.79971090
42DMPK0.79712731
43STK390.75421639
44CHEK10.73986307
45BMPR1B0.72891476
46CDK20.69881233
47CHEK20.68943791
48TNK20.68678577
49BRSK10.68529265
50CSNK1G30.68202012
51CSNK1D0.67630253
52PTK20.66442641
53WNK10.63083910
54AURKB0.60890189
55PRKG10.59815879
56MAPKAPK30.58162778
57VRK10.57731041
58ATM0.56281586
59PKN10.54288745
60MAPK130.52691909
61CDK10.52501563
62CSNK1A1L0.51706410
63TGFBR10.50238894
64PAK10.48886428
65CSNK1G20.47214557
66NTRK30.45948512
67EEF2K0.45125272
68CAMK2A0.43838393
69ATR0.42957649
70PRKCZ0.42502744
71CSNK1E0.38761718
72MTOR0.36033195
73ACVR1B0.34481913
74CHUK0.34373980
75CDK50.34087019
76BRSK20.33665756
77MAP3K50.31917980
78SRPK10.31779271
79PRKACA0.30538535
80PRKACB0.29334780
81LRRK20.29177619
82OXSR10.27079030
83PDK10.25126834
84TYRO30.24956531
85GSK3B0.22894820
86MAPK10.22532551
87PLK40.17176894
88TRPM70.16145116
89CLK10.14572744
90EIF2AK20.13442868
91MAP2K10.11440641
92EGFR0.09082242
93AKT20.08790720
94EPHA40.08536816
95TLK10.08480172
96CDK11A0.07708959
97BRD40.07080547
98MAPK100.06962844
99CAMK10.06478280
100LMTK20.05994771

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.37337289
2Cell cycle_Homo sapiens_hsa041104.57966148
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.35761359
4Mismatch repair_Homo sapiens_hsa034303.86905617
5Oocyte meiosis_Homo sapiens_hsa041143.38087317
6Caffeine metabolism_Homo sapiens_hsa002323.28200580
7Ovarian steroidogenesis_Homo sapiens_hsa049133.13244956
8RNA degradation_Homo sapiens_hsa030183.01700145
9Base excision repair_Homo sapiens_hsa034102.85195619
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.60234900
11Dorso-ventral axis formation_Homo sapiens_hsa043202.50400974
12Homologous recombination_Homo sapiens_hsa034402.47200324
13Nucleotide excision repair_Homo sapiens_hsa034202.45386056
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.41779047
15Fanconi anemia pathway_Homo sapiens_hsa034602.35206402
16Cysteine and methionine metabolism_Homo sapiens_hsa002702.16795487
17DNA replication_Homo sapiens_hsa030302.11597423
18Olfactory transduction_Homo sapiens_hsa047402.10208912
19Circadian rhythm_Homo sapiens_hsa047101.87658319
20p53 signaling pathway_Homo sapiens_hsa041151.69636853
21RNA transport_Homo sapiens_hsa030131.65252920
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64820568
23Phototransduction_Homo sapiens_hsa047441.52954115
24Folate biosynthesis_Homo sapiens_hsa007901.46531689
25Gap junction_Homo sapiens_hsa045401.34725339
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33549400
27Nicotine addiction_Homo sapiens_hsa050331.16100027
28Thyroid cancer_Homo sapiens_hsa052161.14837448
29ABC transporters_Homo sapiens_hsa020101.11869468
30mRNA surveillance pathway_Homo sapiens_hsa030151.01560925
31Morphine addiction_Homo sapiens_hsa050320.99072611
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97070545
33Bile secretion_Homo sapiens_hsa049760.94635003
34RNA polymerase_Homo sapiens_hsa030200.92801016
35SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82320322
36GABAergic synapse_Homo sapiens_hsa047270.79977066
37Inositol phosphate metabolism_Homo sapiens_hsa005620.77768041
38Propanoate metabolism_Homo sapiens_hsa006400.73511663
39Taste transduction_Homo sapiens_hsa047420.73374366
40Synaptic vesicle cycle_Homo sapiens_hsa047210.72950666
41TGF-beta signaling pathway_Homo sapiens_hsa043500.71644265
42Long-term depression_Homo sapiens_hsa047300.63655167
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63246838
44Fatty acid elongation_Homo sapiens_hsa000620.60932817
45Purine metabolism_Homo sapiens_hsa002300.58876060
46FoxO signaling pathway_Homo sapiens_hsa040680.55568513
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55032389
48Vitamin digestion and absorption_Homo sapiens_hsa049770.54327719
49Serotonergic synapse_Homo sapiens_hsa047260.52982103
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51381166
51mTOR signaling pathway_Homo sapiens_hsa041500.50642964
52MicroRNAs in cancer_Homo sapiens_hsa052060.48352295
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38169029
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37589680
55Viral carcinogenesis_Homo sapiens_hsa052030.37339590
56Small cell lung cancer_Homo sapiens_hsa052220.37337638
57Linoleic acid metabolism_Homo sapiens_hsa005910.33403817
58Adherens junction_Homo sapiens_hsa045200.33290320
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32226213
60Ras signaling pathway_Homo sapiens_hsa040140.31124617
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30128466
62HTLV-I infection_Homo sapiens_hsa051660.30086772
63Herpes simplex infection_Homo sapiens_hsa051680.28828322
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.27910656
65Oxytocin signaling pathway_Homo sapiens_hsa049210.27811345
66cAMP signaling pathway_Homo sapiens_hsa040240.25954760
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25777494
68Non-homologous end-joining_Homo sapiens_hsa034500.25737767
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24654713
70Hippo signaling pathway_Homo sapiens_hsa043900.24582988
71Regulation of autophagy_Homo sapiens_hsa041400.22622614
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.22020916
73ErbB signaling pathway_Homo sapiens_hsa040120.20860373
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20304340
75Arginine and proline metabolism_Homo sapiens_hsa003300.20287673
76Wnt signaling pathway_Homo sapiens_hsa043100.18433774
77Glutamatergic synapse_Homo sapiens_hsa047240.16887981
78Ether lipid metabolism_Homo sapiens_hsa005650.15601578
79Arginine biosynthesis_Homo sapiens_hsa002200.15498185
80Cholinergic synapse_Homo sapiens_hsa047250.15074054
81Dopaminergic synapse_Homo sapiens_hsa047280.15039068
82Circadian entrainment_Homo sapiens_hsa047130.14977655
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.14283205
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.13110018
85MAPK signaling pathway_Homo sapiens_hsa040100.12769698
86Endometrial cancer_Homo sapiens_hsa052130.12195071
87Rap1 signaling pathway_Homo sapiens_hsa040150.12178070
88Protein digestion and absorption_Homo sapiens_hsa049740.11989786
89Huntingtons disease_Homo sapiens_hsa050160.11788197
90Calcium signaling pathway_Homo sapiens_hsa040200.11135620
91Tight junction_Homo sapiens_hsa045300.09919899
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09774326
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.07594819
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06820811
95Phagosome_Homo sapiens_hsa041450.06126294
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.05776936
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05328930
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05052456
99Pathways in cancer_Homo sapiens_hsa052000.04767827
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.03991381

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