ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of female gonad development (GO:2000194)	9.15261430
2	regulation of meiosis I (GO:0060631)	8.96351370
3	piRNA metabolic process (GO:0034587)	8.79576994
4	meiotic cell cycle (GO:0051321)	8.20648616
5	retinal cone cell development (GO:0046549)	7.46042908
6	positive regulation of histone H3-K4 methylation (GO:0051571)	7.05327381
7	regulation of histone H3-K9 methylation (GO:0051570)	7.00955467
8	regulation of acrosome reaction (GO:0060046)	6.81482380
9	DNA methylation involved in gamete generation (GO:0043046)	6.73896222
10	regulation of cell maturation (GO:1903429)	6.46785236
11	female gamete generation (GO:0007292)	6.14885749
12	negative regulation of histone methylation (GO:0031061)	5.91948096
13	oocyte development (GO:0048599)	5.86077501
14	glycine transport (GO:0015816)	5.85929187
15	positive regulation of mitotic sister chromatid separation (GO:1901970)	5.69622883
16	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	5.69622883
17	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	5.69622883
18	multicellular organism reproduction (GO:0032504)	5.54987389
19	regulation of steroid hormone secretion (GO:2000831)	5.51888345
20	positive regulation of gastrulation (GO:2000543)	5.49429757
21	gene silencing by RNA (GO:0031047)	5.46859554
22	centriole replication (GO:0007099)	5.26701855
23	negative regulation of reproductive process (GO:2000242)	5.08358721
24	protein localization to kinetochore (GO:0034501)	5.03154017
25	mitotic chromosome condensation (GO:0007076)	5.00214390
26	protein localization to chromosome, centromeric region (GO:0071459)	4.95007082
27	positive regulation of chromosome segregation (GO:0051984)	4.93362767
28	mitotic metaphase plate congression (GO:0007080)	4.85704643
29	primitive streak formation (GO:0090009)	4.77291974
30	establishment of chromosome localization (GO:0051303)	4.70073195
31	regulation of meiosis (GO:0040020)	4.55407548
32	synapsis (GO:0007129)	4.46033032
33	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.45064607
34	synaptonemal complex assembly (GO:0007130)	4.32532824
35	positive regulation of histone methylation (GO:0031062)	4.28010740
36	protein kinase C signaling (GO:0070528)	4.26920049
37	relaxation of smooth muscle (GO:0044557)	4.22642853
38	regulation of steroid hormone biosynthetic process (GO:0090030)	4.19452702
39	L-amino acid import (GO:0043092)	4.18139890
40	regulation of histone H3-K4 methylation (GO:0051569)	4.09691213
41	phosphorelay signal transduction system (GO:0000160)	4.09046716
42	protein localization to chromosome (GO:0034502)	4.01841974
43	chromosome organization involved in meiosis (GO:0070192)	4.01400394
44	regulation of spindle organization (GO:0090224)	4.00189699
45	male meiosis I (GO:0007141)	3.97706809
46	male meiosis (GO:0007140)	3.94252487
47	metaphase plate congression (GO:0051310)	3.92597161
48	negative regulation of execution phase of apoptosis (GO:1900118)	3.89864057
49	positive regulation of humoral immune response (GO:0002922)	3.88231166
50	oogenesis (GO:0048477)	3.84717813
51	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.84087340
52	synaptonemal complex organization (GO:0070193)	3.83260089
53	attachment of spindle microtubules to kinetochore (GO:0008608)	3.83093408
54	DNA alkylation (GO:0006305)	3.75288982
55	DNA methylation (GO:0006306)	3.75288982
56	negative regulation of cAMP-mediated signaling (GO:0043951)	3.73563470
57	regulation of meiotic cell cycle (GO:0051445)	3.72401130
58	CENP-A containing nucleosome assembly (GO:0034080)	3.70240185
59	meiotic nuclear division (GO:0007126)	3.69109563
60	somite rostral/caudal axis specification (GO:0032525)	3.68134168
61	labyrinthine layer development (GO:0060711)	3.66235882
62	regulation of histone methylation (GO:0031060)	3.65745529
63	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.63767488
64	negative regulation of hormone biosynthetic process (GO:0032353)	3.63568265
65	gene silencing (GO:0016458)	3.63209609
66	meiotic cell cycle process (GO:1903046)	3.61957910
67	neuron fate determination (GO:0048664)	3.61289044
68	meiosis I (GO:0007127)	3.60260132
69	DNA damage induced protein phosphorylation (GO:0006975)	3.58989343
70	reproduction (GO:0000003)	3.58614182
71	centriole assembly (GO:0098534)	3.56616771
72	negative regulation of hormone metabolic process (GO:0032351)	3.48404496
73	regulation of spindle checkpoint (GO:0090231)	3.42340962
74	fertilization (GO:0009566)	3.41982731
75	positive regulation of reproductive process (GO:2000243)	3.38920484
76	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.37138572
77	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.34736708
78	chromatin remodeling at centromere (GO:0031055)	3.34658154
79	translesion synthesis (GO:0019985)	3.34619629
80	negative regulation of histone modification (GO:0031057)	3.32210834
81	histone H3-K9 demethylation (GO:0033169)	3.27689274
82	DNA replication-dependent nucleosome assembly (GO:0006335)	3.25259680
83	DNA replication-dependent nucleosome organization (GO:0034723)	3.25259680
84	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.23099342
85	histone-serine phosphorylation (GO:0035404)	3.21582760
86	regulation of corticosteroid hormone secretion (GO:2000846)	3.17620371
87	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.17345551
88	positive regulation of meiosis (GO:0045836)	3.12896131
89	regulation of reproductive process (GO:2000241)	3.11392494
90	regulation of chromatin silencing (GO:0031935)	3.06330256
91	citrulline biosynthetic process (GO:0019240)	3.03739827
92	dopamine biosynthetic process (GO:0042416)	3.01436061
93	histone phosphorylation (GO:0016572)	2.99460955
94	positive regulation of hormone biosynthetic process (GO:0046886)	2.98368851
95	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.97374427
96	mitotic G2/M transition checkpoint (GO:0044818)	2.97158272
97	oocyte maturation (GO:0001556)	2.96422412
98	negative regulation of chromatin modification (GO:1903309)	2.94316925
99	centrosome duplication (GO:0051298)	2.94171008
100	regulation of DNA methylation (GO:0044030)	10.7746062

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.35486863
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	5.34857462
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.81529912
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.25632918
5	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.24554208
6	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.24554208
7	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.24554208
8	E2F7_22180533_ChIP-Seq_HELA_Human	3.22074943
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.19891512
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.92774869
11	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.54370155
12	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.54055571
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.10448932
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.02127381
15	EZH2_22144423_ChIP-Seq_EOC_Human	13.5163243
16	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.96650777
17	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.96339433
18	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.85175224
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76611728
20	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.71973248
21	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.71395709
22	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.67682321
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.64094026
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.54649604
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.54040078
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53628739
27	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.51028076
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50319092
29	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34257639
30	TCF4_23295773_ChIP-Seq_U87_Human	1.29847729
31	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.28580099
32	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.28107907
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.27062569
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27062569
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25717751
36	AR_21909140_ChIP-Seq_LNCAP_Human	1.22713046
37	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21115355
38	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.15633316
39	AR_25329375_ChIP-Seq_VCAP_Human	1.12207284
40	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.10008382
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07654804
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07654804
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.07314749
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07124751
45	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04842473
46	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04646875
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.04570165
48	STAT3_23295773_ChIP-Seq_U87_Human	1.02175377
49	EWS_26573619_Chip-Seq_HEK293_Human	0.99294150
50	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98132407
51	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.97945469
52	GF1_26923725_Chip-Seq_HPCs_Mouse	0.95779134
53	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95374730
54	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93683315
55	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92781591
56	P300_19829295_ChIP-Seq_ESCs_Human	0.91768321
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90931986
58	CBP_21632823_ChIP-Seq_H3396_Human	0.90918987
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.90130154
60	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88315665
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.87704199
62	TP53_16413492_ChIP-PET_HCT116_Human	0.87527130
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87118951
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86855193
65	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.86765888
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.86755983
67	AHR_22903824_ChIP-Seq_MCF-7_Human	0.86192005
68	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.83355257
69	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.83343111
70	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.83075164
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.82569492
72	VDR_22108803_ChIP-Seq_LS180_Human	0.80235237
73	SMRT_27268052_Chip-Seq_Bcells_Human	0.79662540
74	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.77603232
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.77480392
76	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.77327176
77	RNF2_27304074_Chip-Seq_NSC_Mouse	0.73846151
78	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.73658716
79	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.73339149
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.73102756
81	REST_21632747_ChIP-Seq_MESCs_Mouse	0.72759689
82	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.71738632
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.71504569
84	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.70226636
85	TP53_22573176_ChIP-Seq_HFKS_Human	0.69753200
86	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.68609018
87	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.67571767
88	BCAT_22108803_ChIP-Seq_LS180_Human	0.67433328
89	ZNF274_21170338_ChIP-Seq_K562_Hela	0.67387734
90	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.67073495
91	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.66702344
92	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.66609503
93	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.66402729
94	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.65313354
95	DROSHA_22980978_ChIP-Seq_HELA_Human	0.64602139
96	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.64343364
97	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.63571865
98	KLF4_19829295_ChIP-Seq_ESCs_Human	0.63476100
99	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.63124136
100	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.62818131

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	7.92716658
2	MP0008877_abnormal_DNA_methylation	4.98014742
3	MP0006292_abnormal_olfactory_placode	4.85228193
4	MP0008789_abnormal_olfactory_epithelium	4.81030147
5	MP0005394_taste/olfaction_phenotype	4.18495894
6	MP0005499_abnormal_olfactory_system	4.18495894
7	MP0002139_abnormal_hepatobiliary_system	3.21534420
8	MP0003890_abnormal_embryonic-extraembry	3.10341507
9	MP0005395_other_phenotype	3.09844008
10	MP0008057_abnormal_DNA_replication	2.97228741
11	MP0010030_abnormal_orbit_morphology	2.81342625
12	MP0002138_abnormal_hepatobiliary_system	2.77634217
13	MP0003693_abnormal_embryo_hatching	2.77388719
14	MP0002234_abnormal_pharynx_morphology	2.60402612
15	MP0010234_abnormal_vibrissa_follicle	2.52242708
16	MP0000566_synostosis	2.49152260
17	MP0005360_urolithiasis	2.40332776
18	MP0003699_abnormal_female_reproductive	2.33577221
19	MP0003879_abnormal_hair_cell	2.15153740
20	MP0001929_abnormal_gametogenesis	2.12035509
21	MP0002210_abnormal_sex_determination	2.10721194
22	MP0003183_abnormal_peptide_metabolism	2.09248284
23	MP0003077_abnormal_cell_cycle	1.96376889
24	MP0008058_abnormal_DNA_repair	1.85037459
25	MP0010094_abnormal_chromosome_stability	1.84304915
26	MP0005410_abnormal_fertilization	1.84212137
27	MP0003950_abnormal_plasma_membrane	1.73695974
28	MP0000653_abnormal_sex_gland	1.66250566
29	MP0003121_genomic_imprinting	1.60625686
30	MP0002160_abnormal_reproductive_system	1.60024688
31	MP0002161_abnormal_fertility/fecundity	1.58707306
32	MP0001293_anophthalmia	1.41748754
33	MP0003111_abnormal_nucleus_morphology	1.41378711
34	MP0001145_abnormal_male_reproductive	1.37798286
35	MP0010307_abnormal_tumor_latency	1.36883538
36	MP0000631_abnormal_neuroendocrine_gland	1.35020937
37	MP0005646_abnormal_pituitary_gland	1.32847523
38	MP0001984_abnormal_olfaction	1.28491132
39	MP0000762_abnormal_tongue_morphology	1.20742191
40	MP0009840_abnormal_foam_cell	1.20702281
41	MP0000427_abnormal_hair_cycle	1.17710256
42	MP0001119_abnormal_female_reproductive	1.17585795
43	MP0005647_abnormal_sex_gland	1.16569492
44	MP0003698_abnormal_male_reproductive	1.15950326
45	MP0003252_abnormal_bile_duct	1.15729850
46	MP0008932_abnormal_embryonic_tissue	1.15139492
47	MP0002233_abnormal_nose_morphology	1.14643694
48	MP0001730_embryonic_growth_arrest	1.13599480
49	MP0005085_abnormal_gallbladder_physiolo	1.05778075
50	MP0003119_abnormal_digestive_system	1.05618545
51	MP0002272_abnormal_nervous_system	1.03215004
52	MP0005389_reproductive_system_phenotype	1.02281062
53	MP0001986_abnormal_taste_sensitivity	0.94933551
54	MP0010368_abnormal_lymphatic_system	0.94393416
55	MP0005551_abnormal_eye_electrophysiolog	0.94331183
56	MP0004142_abnormal_muscle_tone	0.91224266
57	MP0003136_yellow_coat_color	0.91142284
58	MP0000049_abnormal_middle_ear	0.86800563
59	MP0006276_abnormal_autonomic_nervous	0.85455799
60	MP0003868_abnormal_feces_composition	0.80237875
61	MP0001664_abnormal_digestion	0.79630762
62	MP0001672_abnormal_embryogenesis/_devel	0.76563761
63	MP0005380_embryogenesis_phenotype	0.76563761
64	MP0010678_abnormal_skin_adnexa	0.75729260
65	MP0000350_abnormal_cell_proliferation	0.74770700
66	MP0001666_abnormal_nutrient_absorption	0.73432972
67	MP0001324_abnormal_eye_pigmentation	0.68854751
68	MP0009379_abnormal_foot_pigmentation	0.65883369
69	MP0002751_abnormal_autonomic_nervous	0.63643173
70	MP0001502_abnormal_circadian_rhythm	0.62015957
71	MP0000678_abnormal_parathyroid_gland	0.61521135
72	MP0002796_impaired_skin_barrier	0.60171755
73	MP0001963_abnormal_hearing_physiology	0.59108621
74	MP0000015_abnormal_ear_pigmentation	0.51204067
75	MP0004043_abnormal_pH_regulation	0.50512207
76	MP0004957_abnormal_blastocyst_morpholog	0.49228439
77	MP0002102_abnormal_ear_morphology	0.49148999
78	MP0002084_abnormal_developmental_patter	0.48670850
79	MP0000428_abnormal_craniofacial_morphol	0.48618743
80	MP0003941_abnormal_skin_development	0.47886004
81	MP0003935_abnormal_craniofacial_develop	0.46029654
82	MP0005501_abnormal_skin_physiology	0.43067989
83	MP0003755_abnormal_palate_morphology	0.42976820
84	MP0002127_abnormal_cardiovascular_syste	0.40791993
85	MP0005075_abnormal_melanosome_morpholog	0.40196245
86	MP0002089_abnormal_postnatal_growth/wei	0.38957272
87	MP0002638_abnormal_pupillary_reflex	0.38552051
88	MP0002735_abnormal_chemical_nociception	0.38524272
89	MP0005503_abnormal_tendon_morphology	0.38351162
90	MP0003195_calcinosis	0.37999015
91	MP0002928_abnormal_bile_duct	0.37852456
92	MP0000026_abnormal_inner_ear	0.37598646
93	MP0003936_abnormal_reproductive_system	0.36025760
94	MP0002873_normal_phenotype	0.34944529
95	MP0002090_abnormal_vision	0.34928935
96	MP0002169_no_abnormal_phenotype	0.34414806
97	MP0001486_abnormal_startle_reflex	0.33465940
98	MP0002085_abnormal_embryonic_tissue	0.32940456
99	MP0003656_abnormal_erythrocyte_physiolo	0.32743082
100	MP0005319_abnormal_enzyme/_coenzyme	0.31216060

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	6.76157656
2	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.57992471
3	Abdominal situs inversus (HP:0003363)	5.41792908
4	Abnormality of abdominal situs (HP:0011620)	5.41792908
5	Facial hemangioma (HP:0000329)	5.31329719
6	Osteomalacia (HP:0002749)	4.70400493
7	Abnormal gallbladder physiology (HP:0012438)	4.68153297
8	Cholecystitis (HP:0001082)	4.68153297
9	Lip pit (HP:0100267)	4.66766640
10	Septo-optic dysplasia (HP:0100842)	4.60571697
11	Oligodactyly (hands) (HP:0001180)	4.50514412
12	Impulsivity (HP:0100710)	4.49562997
13	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.14484983
14	Hypoplasia of the fovea (HP:0007750)	4.14484983
15	Hypophosphatemic rickets (HP:0004912)	4.14002046
16	Anterior segment dysgenesis (HP:0007700)	3.96760430
17	Median cleft lip (HP:0000161)	3.83221977
18	Absent septum pellucidum (HP:0001331)	3.79482864
19	Male infertility (HP:0003251)	3.77117149
20	Chromsome breakage (HP:0040012)	3.76902962
21	Azoospermia (HP:0000027)	3.70928185
22	Papillary thyroid carcinoma (HP:0002895)	3.69255960
23	Abnormality of the labia minora (HP:0012880)	3.63042395
24	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.61099166
25	Abnormality of the fovea (HP:0000493)	3.54301661
26	Short tibia (HP:0005736)	3.54065437
27	Enlarged penis (HP:0000040)	3.53359015
28	Gonadotropin excess (HP:0000837)	3.40684605
29	Capillary hemangiomas (HP:0005306)	3.36066935
30	Infertility (HP:0000789)	3.31688428
31	Wrist flexion contracture (HP:0001239)	3.24692412
32	Abnormality of the septum pellucidum (HP:0007375)	3.20666014
33	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.20378843
34	Oligodactyly (HP:0012165)	3.19266930
35	Apathy (HP:0000741)	3.17388674
36	Malnutrition (HP:0004395)	3.12144604
37	Fair hair (HP:0002286)	3.09102430
38	Hypokinesia (HP:0002375)	3.08282233
39	Diminished motivation (HP:0000745)	3.07235133
40	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	3.00984477
41	Premature ovarian failure (HP:0008209)	2.99196258
42	Abnormal spermatogenesis (HP:0008669)	2.77943963
43	Lower limb hyperreflexia (HP:0002395)	2.63369266
44	Stillbirth (HP:0003826)	2.58335341
45	Aplasia/Hypoplasia of the macula (HP:0008059)	2.56872159
46	Maternal diabetes (HP:0009800)	2.52733925
47	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.52071528
48	Truncal obesity (HP:0001956)	2.46047027
49	Abnormal biliary tract physiology (HP:0012439)	2.41725366
50	Bile duct proliferation (HP:0001408)	2.41725366
51	Muscle stiffness (HP:0003552)	2.41532739
52	Urethral obstruction (HP:0000796)	2.40016858
53	Metaphyseal irregularity (HP:0003025)	2.39526668
54	Spinal cord compression (HP:0002176)	2.39292906
55	Aplasia of the musculature (HP:0100854)	2.38795577
56	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.35296944
57	Congenital sensorineural hearing impairment (HP:0008527)	2.33166120
58	Ankle contracture (HP:0006466)	2.32928151
59	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.30597548
60	Optic nerve hypoplasia (HP:0000609)	2.28870910
61	Dysdiadochokinesis (HP:0002075)	2.28303822
62	Intrahepatic cholestasis (HP:0001406)	2.23686278
63	Posterior subcapsular cataract (HP:0007787)	2.23231496
64	Skin pits (HP:0100276)	2.23188499
65	Gaze-evoked nystagmus (HP:0000640)	2.22558889
66	Striae distensae (HP:0001065)	2.22059357
67	Abnormal ciliary motility (HP:0012262)	2.20427604
68	Generalized hypopigmentation of hair (HP:0011358)	2.19680756
69	Conjunctival telangiectasia (HP:0000524)	2.19403737
70	Nephroblastoma (Wilms tumor) (HP:0002667)	2.14886435
71	Abnormality of the phalanges of the hallux (HP:0010057)	2.14488643
72	Sensory axonal neuropathy (HP:0003390)	2.13896014
73	Limb hypertonia (HP:0002509)	2.12038154
74	Hip contracture (HP:0003273)	2.09823507
75	Proximal tubulopathy (HP:0000114)	2.08854116
76	Loss of speech (HP:0002371)	2.06197564
77	Abnormal lung lobation (HP:0002101)	2.04775654
78	Thyroid carcinoma (HP:0002890)	2.03424382
79	Embryonal renal neoplasm (HP:0011794)	2.01900870
80	Abnormality of chromosome stability (HP:0003220)	2.01665553
81	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.00577189
82	Myokymia (HP:0002411)	2.00431563
83	Bundle branch block (HP:0011710)	1.99453085
84	Generalized aminoaciduria (HP:0002909)	1.97151059
85	Bicornuate uterus (HP:0000813)	1.96748063
86	Abnormality of chromosome segregation (HP:0002916)	1.96574903
87	Anhidrosis (HP:0000970)	1.94840816
88	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.93546020
89	Heterotopia (HP:0002282)	1.92073096
90	Microglossia (HP:0000171)	1.84097352
91	Shallow orbits (HP:0000586)	1.79469834
92	Abnormality of the preputium (HP:0100587)	1.79363256
93	Meckel diverticulum (HP:0002245)	1.79242170
94	Small intestinal stenosis (HP:0012848)	1.77375649
95	Duodenal stenosis (HP:0100867)	1.77375649
96	Abnormal respiratory motile cilium physiology (HP:0012261)	1.76575144
97	Increased circulating renin level (HP:0000848)	1.76452162
98	Abnormality of the ileum (HP:0001549)	1.75691404
99	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.75534460
100	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.72707491

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.41440549
2	MAP3K13	5.96467898
3	ARAF	5.79272104
4	NEK6	3.31712099
5	STK24	3.10496184
6	TAOK3	3.03658161
7	BRAF	3.00925548
8	TTK	2.93082083
9	MOS	2.87133282
10	CDK9	2.66111217
11	AURKA	2.26780404
12	MET	2.26207428
13	CDC7	2.02497565
14	RAF1	1.96817781
15	KSR2	1.93962472
16	CDK12	1.87541375
17	PRKCI	1.82132294
18	NTRK2	1.78416229
19	CDK7	1.44196902
20	EIF2AK3	1.42260612
21	TNIK	1.41878330
22	MELK	1.35793574
23	STK3	1.31138605
24	PLK1	1.30712325
25	NUAK1	1.24169058
26	CDK8	1.23418225
27	KSR1	1.18457630
28	TRIM28	1.15064994
29	NEK9	1.08063326
30	ZAK	1.02940139
31	MAP3K8	0.99660245
32	BUB1	0.96482842
33	CDK19	0.94862087
34	MAP3K4	0.93061721
35	MST4	0.92145823
36	PIM1	0.91923801
37	NEK2	0.88188747
38	CSNK1G1	0.87491590
39	TIE1	0.85723209
40	MARK3	0.81715058
41	PLK3	0.79971090
42	DMPK	0.79712731
43	STK39	0.75421639
44	CHEK1	0.73986307
45	BMPR1B	0.72891476
46	CDK2	0.69881233
47	CHEK2	0.68943791
48	TNK2	0.68678577
49	BRSK1	0.68529265
50	CSNK1G3	0.68202012
51	CSNK1D	0.67630253
52	PTK2	0.66442641
53	WNK1	0.63083910
54	AURKB	0.60890189
55	PRKG1	0.59815879
56	MAPKAPK3	0.58162778
57	VRK1	0.57731041
58	ATM	0.56281586
59	PKN1	0.54288745
60	MAPK13	0.52691909
61	CDK1	0.52501563
62	CSNK1A1L	0.51706410
63	TGFBR1	0.50238894
64	PAK1	0.48886428
65	CSNK1G2	0.47214557
66	NTRK3	0.45948512
67	EEF2K	0.45125272
68	CAMK2A	0.43838393
69	ATR	0.42957649
70	PRKCZ	0.42502744
71	CSNK1E	0.38761718
72	MTOR	0.36033195
73	ACVR1B	0.34481913
74	CHUK	0.34373980
75	CDK5	0.34087019
76	BRSK2	0.33665756
77	MAP3K5	0.31917980
78	SRPK1	0.31779271
79	PRKACA	0.30538535
80	PRKACB	0.29334780
81	LRRK2	0.29177619
82	OXSR1	0.27079030
83	PDK1	0.25126834
84	TYRO3	0.24956531
85	GSK3B	0.22894820
86	MAPK1	0.22532551
87	PLK4	0.17176894
88	TRPM7	0.16145116
89	CLK1	0.14572744
90	EIF2AK2	0.13442868
91	MAP2K1	0.11440641
92	EGFR	0.09082242
93	AKT2	0.08790720
94	EPHA4	0.08536816
95	TLK1	0.08480172
96	CDK11A	0.07708959
97	BRD4	0.07080547
98	MAPK10	0.06962844
99	CAMK1	0.06478280
100	LMTK2	0.05994771

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.37337289
2	Cell cycle_Homo sapiens_hsa04110	4.57966148
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	4.35761359
4	Mismatch repair_Homo sapiens_hsa03430	3.86905617
5	Oocyte meiosis_Homo sapiens_hsa04114	3.38087317
6	Caffeine metabolism_Homo sapiens_hsa00232	3.28200580
7	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.13244956
8	RNA degradation_Homo sapiens_hsa03018	3.01700145
9	Base excision repair_Homo sapiens_hsa03410	2.85195619
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.60234900
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.50400974
12	Homologous recombination_Homo sapiens_hsa03440	2.47200324
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.45386056
14	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.41779047
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.35206402
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.16795487
17	DNA replication_Homo sapiens_hsa03030	2.11597423
18	Olfactory transduction_Homo sapiens_hsa04740	2.10208912
19	Circadian rhythm_Homo sapiens_hsa04710	1.87658319
20	p53 signaling pathway_Homo sapiens_hsa04115	1.69636853
21	RNA transport_Homo sapiens_hsa03013	1.65252920
22	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.64820568
23	Phototransduction_Homo sapiens_hsa04744	1.52954115
24	Folate biosynthesis_Homo sapiens_hsa00790	1.46531689
25	Gap junction_Homo sapiens_hsa04540	1.34725339
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33549400
27	Nicotine addiction_Homo sapiens_hsa05033	1.16100027
28	Thyroid cancer_Homo sapiens_hsa05216	1.14837448
29	ABC transporters_Homo sapiens_hsa02010	1.11869468
30	mRNA surveillance pathway_Homo sapiens_hsa03015	1.01560925
31	Morphine addiction_Homo sapiens_hsa05032	0.99072611
32	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.97070545
33	Bile secretion_Homo sapiens_hsa04976	0.94635003
34	RNA polymerase_Homo sapiens_hsa03020	0.92801016
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.82320322
36	GABAergic synapse_Homo sapiens_hsa04727	0.79977066
37	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.77768041
38	Propanoate metabolism_Homo sapiens_hsa00640	0.73511663
39	Taste transduction_Homo sapiens_hsa04742	0.73374366
40	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.72950666
41	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.71644265
42	Long-term depression_Homo sapiens_hsa04730	0.63655167
43	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.63246838
44	Fatty acid elongation_Homo sapiens_hsa00062	0.60932817
45	Purine metabolism_Homo sapiens_hsa00230	0.58876060
46	FoxO signaling pathway_Homo sapiens_hsa04068	0.55568513
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55032389
48	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.54327719
49	Serotonergic synapse_Homo sapiens_hsa04726	0.52982103
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51381166
51	mTOR signaling pathway_Homo sapiens_hsa04150	0.50642964
52	MicroRNAs in cancer_Homo sapiens_hsa05206	0.48352295
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.38169029
54	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.37589680
55	Viral carcinogenesis_Homo sapiens_hsa05203	0.37339590
56	Small cell lung cancer_Homo sapiens_hsa05222	0.37337638
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.33403817
58	Adherens junction_Homo sapiens_hsa04520	0.33290320
59	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.32226213
60	Ras signaling pathway_Homo sapiens_hsa04014	0.31124617
61	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.30128466
62	HTLV-I infection_Homo sapiens_hsa05166	0.30086772
63	Herpes simplex infection_Homo sapiens_hsa05168	0.28828322
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.27910656
65	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.27811345
66	cAMP signaling pathway_Homo sapiens_hsa04024	0.25954760
67	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.25777494
68	Non-homologous end-joining_Homo sapiens_hsa03450	0.25737767
69	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.24654713
70	Hippo signaling pathway_Homo sapiens_hsa04390	0.24582988
71	Regulation of autophagy_Homo sapiens_hsa04140	0.22622614
72	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.22020916
73	ErbB signaling pathway_Homo sapiens_hsa04012	0.20860373
74	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.20304340
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.20287673
76	Wnt signaling pathway_Homo sapiens_hsa04310	0.18433774
77	Glutamatergic synapse_Homo sapiens_hsa04724	0.16887981
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.15601578
79	Arginine biosynthesis_Homo sapiens_hsa00220	0.15498185
80	Cholinergic synapse_Homo sapiens_hsa04725	0.15074054
81	Dopaminergic synapse_Homo sapiens_hsa04728	0.15039068
82	Circadian entrainment_Homo sapiens_hsa04713	0.14977655
83	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.14283205
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.13110018
85	MAPK signaling pathway_Homo sapiens_hsa04010	0.12769698
86	Endometrial cancer_Homo sapiens_hsa05213	0.12195071
87	Rap1 signaling pathway_Homo sapiens_hsa04015	0.12178070
88	Protein digestion and absorption_Homo sapiens_hsa04974	0.11989786
89	Huntingtons disease_Homo sapiens_hsa05016	0.11788197
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.11135620
91	Tight junction_Homo sapiens_hsa04530	0.09919899
92	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.09774326
93	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.07594819
94	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.06820811
95	Phagosome_Homo sapiens_hsa04145	0.06126294
96	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.05776936
97	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.05328930
98	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.05052456
99	Pathways in cancer_Homo sapiens_hsa05200	0.04767827
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.03991381

TRIM77

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »