TRIM8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1barbed-end actin filament capping (GO:0051016)3.49968478
2axon ensheathment in central nervous system (GO:0032291)3.36038279
3central nervous system myelination (GO:0022010)3.36038279
4negative regulation of cell killing (GO:0031342)3.11160483
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11160483
6regulation of extracellular matrix disassembly (GO:0010715)3.09495495
7response to laminar fluid shear stress (GO:0034616)3.06907580
8cytoskeletal anchoring at plasma membrane (GO:0007016)2.98551620
9positive regulation of histone deacetylation (GO:0031065)2.97439219
10negative regulation of erythrocyte differentiation (GO:0045647)2.96085090
11positive regulation of extracellular matrix organization (GO:1903055)2.93241190
12positive regulation of receptor recycling (GO:0001921)2.92698789
13hypotonic response (GO:0006971)2.82120498
14skin morphogenesis (GO:0043589)2.70582542
15semaphorin-plexin signaling pathway (GO:0071526)2.67819040
16adenosine receptor signaling pathway (GO:0001973)2.63232451
17negative regulation of fatty acid transport (GO:2000192)2.59857603
18adaptation of signaling pathway (GO:0023058)2.56777355
19positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.55864933
20cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.55659578
21focal adhesion assembly (GO:0048041)2.54853700
22cell-substrate adherens junction assembly (GO:0007045)2.54853700
23basement membrane organization (GO:0071711)2.54506710
24positive regulation of blood vessel endothelial cell migration (GO:0043536)2.54491415
25negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.54092480
26protein localization to endosome (GO:0036010)2.53003590
27vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.52494020
28hemidesmosome assembly (GO:0031581)2.52021463
29mannose metabolic process (GO:0006013)2.51440693
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49450570
31regulation of ARF GTPase activity (GO:0032312)2.48707713
32regulation of extracellular matrix organization (GO:1903053)2.47940077
33regulation of early endosome to late endosome transport (GO:2000641)2.45781088
34negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.44213483
35tolerance induction (GO:0002507)2.42653916
36vascular endothelial growth factor signaling pathway (GO:0038084)2.42188242
37dendritic spine morphogenesis (GO:0060997)2.39747178
38L-amino acid import (GO:0043092)2.38962658
39amino acid import (GO:0043090)2.38395862
40positive regulation of Cdc42 GTPase activity (GO:0043089)2.37477057
41negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.36832666
42stress fiber assembly (GO:0043149)2.36793388
43postsynaptic membrane organization (GO:0001941)2.36524097
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.35640353
45ensheathment of neurons (GO:0007272)2.34199016
46axon ensheathment (GO:0008366)2.34199016
47membrane tubulation (GO:0097320)2.33189158
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.33032831
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.33032831
50positive regulation by organism of defense response of other organism involved in symbiotic interact2.33032831
51modulation by symbiont of host immune response (GO:0052553)2.33032831
52positive regulation by symbiont of host defense response (GO:0052509)2.33032831
53modulation by symbiont of host defense response (GO:0052031)2.33032831
54negative regulation of stress fiber assembly (GO:0051497)2.33013437
55regulation of macrophage cytokine production (GO:0010935)2.32411176
56antigen processing and presentation of endogenous antigen (GO:0019883)2.31203540
57atrioventricular valve morphogenesis (GO:0003181)2.29795363
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.29611296
59glomerular visceral epithelial cell development (GO:0072015)2.29316119
60response to muramyl dipeptide (GO:0032495)2.28961475
61sodium ion export (GO:0071436)2.28675249
62protein targeting to plasma membrane (GO:0072661)2.26931472
63regulation of glucose import in response to insulin stimulus (GO:2001273)2.26549223
64response to fluid shear stress (GO:0034405)2.26467723
65fibril organization (GO:0097435)2.26258497
66myelination (GO:0042552)2.25176252
67planar cell polarity pathway involved in neural tube closure (GO:0090179)2.24495187
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.24340903
69regulation of ARF protein signal transduction (GO:0032012)2.23774910
70endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.23400486
71protein heterotrimerization (GO:0070208)2.23376424
72oligodendrocyte differentiation (GO:0048709)2.22187473
73cell-substrate junction assembly (GO:0007044)2.21231763
74positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.18564226
75extracellular fibril organization (GO:0043206)2.18368638
76regulation of p38MAPK cascade (GO:1900744)2.17587192
77cell volume homeostasis (GO:0006884)2.16177857
78negative regulation of homotypic cell-cell adhesion (GO:0034111)2.16132375
79venous blood vessel morphogenesis (GO:0048845)2.15091887
80extracellular matrix assembly (GO:0085029)2.15063762
81megakaryocyte development (GO:0035855)2.14595907
82myelin maintenance (GO:0043217)2.13629589
83positive regulation of developmental pigmentation (GO:0048087)2.13430427
84glomerular epithelial cell development (GO:0072310)2.12820129
85dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.11039730
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.10856897
87negative regulation of T-helper cell differentiation (GO:0045623)2.10856897
88angiogenesis involved in wound healing (GO:0060055)2.10645126
89detection of temperature stimulus involved in sensory perception (GO:0050961)2.10323192
90detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.10323192
91positive regulation of protein dephosphorylation (GO:0035307)2.10173884
92positive regulation of p38MAPK cascade (GO:1900745)2.10047355
93negative regulation of bone resorption (GO:0045779)2.09462930
94endodermal cell differentiation (GO:0035987)2.08873146
95regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.08421718
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.08297808
97regulation of pigment cell differentiation (GO:0050932)2.07255921
98apoptotic cell clearance (GO:0043277)2.07238598
99response to peptidoglycan (GO:0032494)2.07236024
100regulation of interleukin-13 production (GO:0032656)2.07232383
101modulation by symbiont of host cellular process (GO:0044068)2.07011609
102pinocytosis (GO:0006907)2.06650365
103cell-cell junction maintenance (GO:0045217)2.06578915
104myelination in peripheral nervous system (GO:0022011)2.06231394
105peripheral nervous system axon ensheathment (GO:0032292)2.06231394
106endocytic recycling (GO:0032456)2.05930964
107germinal center formation (GO:0002467)2.05900021
108negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.05849731
109negative regulation of actin filament bundle assembly (GO:0032232)2.05334866
110embryonic process involved in female pregnancy (GO:0060136)2.04564108
111epithelial cell-cell adhesion (GO:0090136)2.04205721
112ear development (GO:0043583)2.03985749
113establishment of apical/basal cell polarity (GO:0035089)2.03909961
114negative regulation of Ras GTPase activity (GO:0034261)2.03677888
115negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.03053255
116negative regulation of tissue remodeling (GO:0034104)2.02361535
117regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.02188415
118regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.01864143
119activation of JUN kinase activity (GO:0007257)2.01795751
120cortical actin cytoskeleton organization (GO:0030866)2.01680647
121adhesion of symbiont to host cell (GO:0044650)2.01616448
122virion attachment to host cell (GO:0019062)2.01616448
123apoptotic process involved in morphogenesis (GO:0060561)2.01499297
124regulation of monocyte differentiation (GO:0045655)2.01461012
125positive regulation of lipid kinase activity (GO:0090218)2.01372268
126detection of other organism (GO:0098543)2.00683228
127head development (GO:0060322)2.00607535
128regulation of leukocyte degranulation (GO:0043300)2.00189718
129pattern specification involved in kidney development (GO:0061004)1.99903574
130phagocytosis, engulfment (GO:0006911)1.99881594
131Rho protein signal transduction (GO:0007266)1.99736499
132cellular response to epinephrine stimulus (GO:0071872)1.99564582
133polarized epithelial cell differentiation (GO:0030859)1.99236945
134substrate-dependent cell migration (GO:0006929)1.99036725
135lateral sprouting from an epithelium (GO:0060601)1.98943881
136astrocyte differentiation (GO:0048708)1.98844311
137detection of molecule of bacterial origin (GO:0032490)1.98308851
138positive regulation of metanephros development (GO:0072216)1.98144475
139negative regulation of cell-matrix adhesion (GO:0001953)1.97992446
140regulation of lipid kinase activity (GO:0043550)1.97419157
141filopodium assembly (GO:0046847)1.96460713
142positive thymic T cell selection (GO:0045059)1.96426025
143actin filament bundle organization (GO:0061572)1.96424039
144actin filament bundle assembly (GO:0051017)1.96424039
145negative regulation of smooth muscle cell migration (GO:0014912)1.96298148
146cortical cytoskeleton organization (GO:0030865)1.95862860
147negative regulation of focal adhesion assembly (GO:0051895)1.95664550
148negative regulation of cell junction assembly (GO:1901889)1.95664550
149negative regulation of adherens junction organization (GO:1903392)1.95664550
150positive regulation of cellular amide metabolic process (GO:0034250)1.95559057
151signal complex assembly (GO:0007172)1.95209548
152mesodermal cell differentiation (GO:0048333)1.95197638
153neuron remodeling (GO:0016322)1.94974979
154establishment or maintenance of bipolar cell polarity (GO:0061245)1.94523227
155establishment or maintenance of apical/basal cell polarity (GO:0035088)1.94523227
156positive regulation of gliogenesis (GO:0014015)1.94284284
157regulation of integrin activation (GO:0033623)1.94079644
158positive regulation of Rap GTPase activity (GO:0032854)1.93825092
159negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)1.93416297
160adherens junction assembly (GO:0034333)1.93262541
161activated T cell proliferation (GO:0050798)1.93023726
162establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)1.91771817
163regulation of T-helper 2 cell differentiation (GO:0045628)1.90866454
164epithelial cell fate commitment (GO:0072148)1.89479482
165astrocyte development (GO:0014002)1.89104790
166establishment or maintenance of monopolar cell polarity (GO:0061339)1.88874670
167establishment of monopolar cell polarity (GO:0061162)1.88874670
168surfactant homeostasis (GO:0043129)1.88343922
169endothelial cell chemotaxis (GO:0035767)1.88093607
170negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)1.88070863
171metanephric nephron epithelium development (GO:0072243)1.88042294
172forebrain neuron differentiation (GO:0021879)1.87974263
173cellular response to fluid shear stress (GO:0071498)1.87830316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.02706895
2STAT6_21828071_ChIP-Seq_BEAS2B_Human2.88198789
3* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.59642508
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.50210703
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.08046427
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.05746611
7* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.97247968
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91813184
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91813184
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91813184
11* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.91155709
12* KDM2B_26808549_Chip-Seq_DND41_Human1.90541112
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88044996
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87353063
15SCL_19346495_ChIP-Seq_HPC-7_Human1.86079671
16KDM2B_26808549_Chip-Seq_K562_Human1.83064741
17VDR_21846776_ChIP-Seq_THP-1_Human1.82285214
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80372379
19* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78942430
20LXR_22292898_ChIP-Seq_THP-1_Human1.78884458
21* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75092381
22* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74878765
23* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73703031
24* TCF7_22412390_ChIP-Seq_EML_Mouse1.71559016
25CLOCK_20551151_ChIP-Seq_293T_Human1.71253996
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71252004
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71252004
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71113715
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.69669671
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69538799
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.69537498
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68655122
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67526259
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63894224
35* KDM2B_26808549_Chip-Seq_JURKAT_Human1.63276263
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62067830
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60410561
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58070995
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56162580
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55068578
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54537330
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53838237
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51637541
44* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51008289
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.50638546
46* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47477401
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47042089
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.46700452
49RUNX_20019798_ChIP-Seq_JUKART_Human1.45109332
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43292400
51* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42477585
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.42213744
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41957257
54* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39461230
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39163160
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37665797
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.37482323
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.37076446
59VDR_24763502_ChIP-Seq_THP-1_Human1.35010772
60GATA1_19941826_ChIP-Seq_K562_Human1.34881253
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33266329
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31900691
63* RING1B_27294783_Chip-Seq_NPCs_Mouse1.29527968
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26274689
65MYC_22102868_ChIP-Seq_BL_Human1.26087619
66* TBX20_22080862_ChIP-Seq_HEART_Mouse1.26043446
67* TBX20_22328084_ChIP-Seq_HEART_Mouse1.26043446
68* SPI1_23127762_ChIP-Seq_K562_Human1.24310587
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23912920
70DROSHA_22980978_ChIP-Seq_HELA_Human1.23819694
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.23748901
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23442100
73* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21254778
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20888083
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.20886119
76* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20220914
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.19674283
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18695210
79AHR_22903824_ChIP-Seq_MCF-7_Human1.18550510
80* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17711952
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17703556
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17238636
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16406393
84* RUNX1_22412390_ChIP-Seq_EML_Mouse1.15739057
85EZH2_22144423_ChIP-Seq_EOC_Human1.15489385
86SMC4_20622854_ChIP-Seq_HELA_Human1.15349652
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15185237
88* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.14664804
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13486921
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13116566
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.12943073
92* CREB1_26743006_Chip-Seq_LNCaP_Human1.12903334
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12573118
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12135474
95TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11605199
96P68_20966046_ChIP-Seq_HELA_Human1.11054770
97RUNX1_27514584_Chip-Seq_MCF-7_Human1.11046090
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10511900
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10504133
100CTCF_27219007_Chip-Seq_Bcells_Human1.10486084
101RXR_22158963_ChIP-Seq_LIVER_Mouse1.09969415
102BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09791221
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09671084
104* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09459834
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.08820955
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08528456
107* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08512948
108TP53_22127205_ChIP-Seq_IMR90_Human1.08215124
109* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07769753
110* TET1_21451524_ChIP-Seq_MESCs_Mouse1.06679436
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05986135
112ZNF263_19887448_ChIP-Seq_K562_Human1.05923016
113* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05552628
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05066781
115* MAF_26560356_Chip-Seq_TH1_Human1.05066184
116GATA2_21666600_ChIP-Seq_HMVEC_Human1.04898460
117MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04346095
118WT1_19549856_ChIP-ChIP_CCG9911_Human1.04269912
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03698872
120PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03578639
121* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03176004
122* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02391534
123* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02155451
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02123522
125* SA1_27219007_Chip-Seq_ERYTHROID_Human1.01848634
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01807444
127* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01528429
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01307457
129STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00850186
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00167672
131FOXO3_23340844_ChIP-Seq_DLD1_Human0.99978438
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99469586
133* UBF1/2_26484160_Chip-Seq_HMECs_Human0.98767838
134* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98362399
135IRF8_27001747_Chip-Seq_BMDM_Mouse0.98193128
136* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97346389
137KLF5_25053715_ChIP-Seq_YYC3_Human0.97329023
138* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97248856
139* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97222109
140* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96416452
141RARB_27405468_Chip-Seq_BRAIN_Mouse0.95771695
142* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95262774
143SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95104418
144EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95092449
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.94547622
146EGR1_19374776_ChIP-ChIP_THP-1_Human0.92769804
147* TP63_22573176_ChIP-Seq_HFKS_Human0.92720166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.90712417
2MP0004858_abnormal_nervous_system2.75624787
3MP0003303_peritoneal_inflammation2.46786376
4MP0000751_myopathy2.22397773
5MP0000920_abnormal_myelination2.11682687
6MP0005623_abnormal_meninges_morphology1.98857613
7MP0003300_gastrointestinal_ulcer1.96478077
8MP0003075_altered_response_to1.86147627
9MP0002254_reproductive_system_inflammat1.86009220
10MP0009840_abnormal_foam_cell1.80032756
11MP0005503_abnormal_tendon_morphology1.79996529
12MP0005275_abnormal_skin_tensile1.78236811
13MP0000685_abnormal_immune_system1.63734022
14MP0004510_myositis1.62349929
15MP0005670_abnormal_white_adipose1.61499919
16MP0008961_abnormal_basal_metabolism1.61309183
17MP0005075_abnormal_melanosome_morpholog1.59050786
18MP0001958_emphysema1.58633455
19MP0001348_abnormal_lacrimal_gland1.56850524
20MP0005387_immune_system_phenotype1.56453918
21MP0001790_abnormal_immune_system1.56453918
22MP0005451_abnormal_body_composition1.55206539
23MP0003690_abnormal_glial_cell1.54497544
24MP0005666_abnormal_adipose_tissue1.53158208
25MP0008260_abnormal_autophagy1.52994488
26MP0009278_abnormal_bone_marrow1.50960559
27MP0004885_abnormal_endolymph1.50633518
28MP0004272_abnormal_basement_membrane1.48892570
29MP0003172_abnormal_lysosome_physiology1.46916599
30MP0003279_aneurysm1.45606314
31MP0003634_abnormal_glial_cell1.44761373
32MP0003283_abnormal_digestive_organ1.43896822
33MP0006082_CNS_inflammation1.43583382
34MP0003828_pulmonary_edema1.43558141
35MP0005058_abnormal_lysosome_morphology1.41835776
36MP0005375_adipose_tissue_phenotype1.41658447
37MP0005167_abnormal_blood-brain_barrier1.41391728
38MP0009780_abnormal_chondrocyte_physiolo1.38473629
39MP0004859_abnormal_synaptic_plasticity1.38238749
40MP0002249_abnormal_larynx_morphology1.35366777
41MP0000858_altered_metastatic_potential1.34849831
42MP0004270_analgesia1.33857564
43MP0005257_abnormal_intraocular_pressure1.33569235
44MP0003045_fibrosis1.31535366
45MP0003938_abnormal_ear_development1.30397238
46MP0005076_abnormal_cell_differentiation1.29791517
47MP0003091_abnormal_cell_migration1.27569647
48MP0001849_ear_inflammation1.27204683
49MP0004130_abnormal_muscle_cell1.27116682
50MP0001542_abnormal_bone_strength1.26903787
51MP0005423_abnormal_somatic_nervous1.26595620
52MP0005390_skeleton_phenotype1.26568982
53MP0003724_increased_susceptibility_to1.24698148
54MP0000049_abnormal_middle_ear1.23333618
55MP0004947_skin_inflammation1.21898843
56MP0002896_abnormal_bone_mineralization1.21682563
57MP0003191_abnormal_cellular_cholesterol1.21446606
58MP0003453_abnormal_keratinocyte_physiol1.19903736
59MP0004133_heterotaxia1.19596839
60MP0002877_abnormal_melanocyte_morpholog1.18882269
61MP0004185_abnormal_adipocyte_glucose1.16697816
62MP0005409_darkened_coat_color1.16518295
63MP0000465_gastrointestinal_hemorrhage1.14999156
64MP0003566_abnormal_cell_adhesion1.14907614
65MP0005174_abnormal_tail_pigmentation1.13179431
66MP0001851_eye_inflammation1.12748380
67MP0006138_congestive_heart_failure1.11277313
68MP0002009_preneoplasia1.11117829
69MP0002697_abnormal_eye_size1.10243825
70MP0000733_abnormal_muscle_development1.09528844
71MP0005000_abnormal_immune_tolerance1.09363734
72MP0005595_abnormal_vascular_smooth1.09181178
73MP0002277_abnormal_respiratory_mucosa1.09111468
74MP0003950_abnormal_plasma_membrane1.08591384
75MP0002405_respiratory_system_inflammati1.08051476
76MP0000778_abnormal_nervous_system1.07781393
77MP0005508_abnormal_skeleton_morphology1.06403271
78MP0000003_abnormal_adipose_tissue1.06105583
79MP0003329_amyloid_beta_deposits1.05399475
80MP0004381_abnormal_hair_follicle1.04623851
81MP0003436_decreased_susceptibility_to1.04564081
82MP0002998_abnormal_bone_remodeling1.03772035
83MP0000678_abnormal_parathyroid_gland1.01638553
84MP0003136_yellow_coat_color0.99960269
85MP0005464_abnormal_platelet_physiology0.99537416
86MP0000759_abnormal_skeletal_muscle0.99535230
87MP0009384_cardiac_valve_regurgitation0.98572105
88MP0000343_altered_response_to0.98559282
89MP0002060_abnormal_skin_morphology0.97743450
90MP0005023_abnormal_wound_healing0.96627739
91MP0004087_abnormal_muscle_fiber0.95250762
92MP0003879_abnormal_hair_cell0.94648214
93MP0000749_muscle_degeneration0.94003509
94MP0004883_abnormal_blood_vessel0.92919519
95MP0001879_abnormal_lymphatic_vessel0.92505403
96MP0002796_impaired_skin_barrier0.92333754
97MP0002971_abnormal_brown_adipose0.91739987
98MP0003866_abnormal_defecation0.91611898
99MP0005164_abnormal_response_to0.91260275
100MP0003183_abnormal_peptide_metabolism0.91215930
101MP0002108_abnormal_muscle_morphology0.91068694
102MP0000604_amyloidosis0.91058820
103MP0005671_abnormal_response_to0.90916508
104MP0004742_abnormal_vestibular_system0.90224993
105MP0008438_abnormal_cutaneous_collagen0.89852705
106MP0009379_abnormal_foot_pigmentation0.88782940
107MP0000750_abnormal_muscle_regeneration0.88652692
108MP0002064_seizures0.88584396
109MP0005025_abnormal_response_to0.87012263
110MP0001800_abnormal_humoral_immune0.86473522
111MP0005165_increased_susceptibility_to0.86434033
112MP0000747_muscle_weakness0.86281749
113MP0002089_abnormal_postnatal_growth/wei0.85799590
114MP0002452_abnormal_antigen_presenting0.85378592
115MP0003448_altered_tumor_morphology0.85348444
116MP0008569_lethality_at_weaning0.85095258
117MP0002295_abnormal_pulmonary_circulatio0.84626803
118MP0002420_abnormal_adaptive_immunity0.83350808
119MP0002723_abnormal_immune_serum0.82975553
120MP0002925_abnormal_cardiovascular_devel0.82814068
121MP0000767_abnormal_smooth_muscle0.81317481
122MP0001819_abnormal_immune_cell0.80869022
123MP0010630_abnormal_cardiac_muscle0.80723314
124MP0003941_abnormal_skin_development0.80440202
125MP0003633_abnormal_nervous_system0.80423643
126MP0008874_decreased_physiological_sensi0.80329780
127MP0000249_abnormal_blood_vessel0.80170586
128MP0004084_abnormal_cardiac_muscle0.79938333
129MP0003635_abnormal_synaptic_transmissio0.78928009
130MP0001614_abnormal_blood_vessel0.78585523
131MP0010368_abnormal_lymphatic_system0.78331713
132MP0002933_joint_inflammation0.78098294
133MP0005166_decreased_susceptibility_to0.77995892
134MP0002166_altered_tumor_susceptibility0.76488579
135MP0003795_abnormal_bone_structure0.76280193
136MP0000534_abnormal_ureter_morphology0.76254224
137MP0000013_abnormal_adipose_tissue0.76133930
138MP0005388_respiratory_system_phenotype0.75957265
139MP0002133_abnormal_respiratory_system0.75957265
140MP0008004_abnormal_stomach_pH0.75342894
141MP0000762_abnormal_tongue_morphology0.74990437
142MP0002419_abnormal_innate_immunity0.72424049
143MP0001533_abnormal_skeleton_physiology0.72081157
144MP0005193_abnormal_anterior_eye0.71977956

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.76932828
2Obstructive sleep apnea (HP:0002870)3.45392168
3Aortic aneurysm (HP:0004942)3.30496765
4Diplopia (HP:0000651)3.24570624
5Abnormality of binocular vision (HP:0011514)3.24570624
6Neurofibrillary tangles (HP:0002185)3.23799949
7Increased connective tissue (HP:0009025)3.17774128
8Split foot (HP:0001839)3.16777369
9Distal lower limb muscle weakness (HP:0009053)3.08411591
10Increased variability in muscle fiber diameter (HP:0003557)3.05035069
11Supranuclear gaze palsy (HP:0000605)3.02909502
12Nuclear cataract (HP:0100018)2.92378287
13Peripheral hypomyelination (HP:0007182)2.92339717
14Cerebral inclusion bodies (HP:0100314)2.88450362
15Atrophic scars (HP:0001075)2.88207630
16Aortic dissection (HP:0002647)2.82592117
17Broad face (HP:0000283)2.79413909
18Milia (HP:0001056)2.77905742
19Cervical subluxation (HP:0003308)2.71732210
20Abnormality of skeletal muscle fiber size (HP:0012084)2.71494964
21Vertebral compression fractures (HP:0002953)2.69054027
22Type 1 muscle fiber predominance (HP:0003803)2.67508783
23Muscle fiber splitting (HP:0003555)2.59428090
24Cerebral aneurysm (HP:0004944)2.56879115
25Distal lower limb amyotrophy (HP:0008944)2.56727193
26Spinal rigidity (HP:0003306)2.56527798
27Increased cerebral lipofuscin (HP:0011813)2.54925904
28Shallow orbits (HP:0000586)2.54921115
29Interstitial pulmonary disease (HP:0006530)2.53462897
30Aneurysm (HP:0002617)2.51620108
31Annular pancreas (HP:0001734)2.49104487
32Spondylolisthesis (HP:0003302)2.48229718
33Disproportionate tall stature (HP:0001519)2.48196827
34Clumsiness (HP:0002312)2.48108459
35Bronchomalacia (HP:0002780)2.46751855
36Dilatation of the ascending aorta (HP:0005111)2.45707314
37Hemiparesis (HP:0001269)2.44065499
38Hemiplegia (HP:0002301)2.43268741
39Mitral regurgitation (HP:0001653)2.42488298
40Eczematoid dermatitis (HP:0000976)2.41522371
41Peritonitis (HP:0002586)2.40179848
42Arnold-Chiari malformation (HP:0002308)2.33480829
43Asymmetric septal hypertrophy (HP:0001670)2.31491606
44Lower limb amyotrophy (HP:0007210)2.30873615
45Mildly elevated creatine phosphokinase (HP:0008180)2.28990104
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.28956018
47Dysostosis multiplex (HP:0000943)2.26665450
48Premature skin wrinkling (HP:0100678)2.24956309
49Upper limb amyotrophy (HP:0009129)2.24202064
50Distal upper limb amyotrophy (HP:0007149)2.24202064
51Apathy (HP:0000741)2.19231623
52Wormian bones (HP:0002645)2.18708762
53Amyloidosis (HP:0011034)2.18643597
54Partial duplication of thumb phalanx (HP:0009944)2.18231526
55Fragile skin (HP:0001030)2.17633355
56Blue sclerae (HP:0000592)2.15511593
57Degeneration of the lateral corticospinal tracts (HP:0002314)2.14730846
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14730846
59Ankle contracture (HP:0006466)2.14148337
60Hyporeflexia of lower limbs (HP:0002600)2.12699180
61Intestinal fistula (HP:0100819)2.11453878
62Aplasia cutis congenita (HP:0001057)2.10908354
63Aplasia of the phalanges of the hand (HP:0009802)2.10120612
64Aplasia involving bones of the extremities (HP:0009825)2.10120612
65Aplasia involving bones of the upper limbs (HP:0009823)2.10120612
66Difficulty climbing stairs (HP:0003551)2.09102482
67Rib fusion (HP:0000902)2.08370951
68Rapidly progressive (HP:0003678)2.07497207
69Hemorrhage of the eye (HP:0011885)2.05916742
70Thin bony cortex (HP:0002753)2.03956440
71Diminished motivation (HP:0000745)2.03327343
72Neonatal respiratory distress (HP:0002643)2.02694247
73Slender build (HP:0001533)2.01091032
74Esophageal atresia (HP:0002032)2.00842279
75Abnormality of the nasal mucosa (HP:0000433)2.00764037
76Joint stiffness (HP:0001387)2.00028311
77Mitral valve prolapse (HP:0001634)1.99336578
78Hyperacusis (HP:0010780)1.98411078
79Vaginal fistula (HP:0004320)1.98098316
80Rectovaginal fistula (HP:0000143)1.97920035
81Rectal fistula (HP:0100590)1.97920035
82Macroorchidism (HP:0000053)1.97729140
83Zonular cataract (HP:0010920)1.95119320
84Genu recurvatum (HP:0002816)1.94910263
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94896052
86Bladder diverticulum (HP:0000015)1.94767757
87Partial duplication of the phalanx of hand (HP:0009999)1.94134861
88Inflammation of the large intestine (HP:0002037)1.93667303
89Gastrointestinal inflammation (HP:0004386)1.93565228
90Joint laxity (HP:0001388)1.91286388
91Amblyopia (HP:0000646)1.90846045
92Colitis (HP:0002583)1.88330166
93Polygenic inheritance (HP:0010982)1.88300374
94Centrally nucleated skeletal muscle fibers (HP:0003687)1.87313815
95Deep venous thrombosis (HP:0002625)1.87204720
96Megalencephaly (HP:0001355)1.86947570
97Polycythemia (HP:0001901)1.86782863
98Easy fatigability (HP:0003388)1.86523202
99Pustule (HP:0200039)1.85826135
100Coxa vara (HP:0002812)1.84946028
101Short nail (HP:0001799)1.84329069
102Abnormality of polysaccharide metabolism (HP:0011012)1.84317480
103Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84317480
104Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84317480
105Abnormality of complement system (HP:0005339)1.83389072
106Aortic regurgitation (HP:0001659)1.83276471
107Neonatal short-limb short stature (HP:0008921)1.82848897
108Spontaneous hematomas (HP:0007420)1.81990668
109Ulnar bowing (HP:0003031)1.81652767
110Emphysema (HP:0002097)1.80856341
111Renal salt wasting (HP:0000127)1.79735227
112Axonal loss (HP:0003447)1.79639011
113Glomerulonephritis (HP:0000099)1.79026900
114Round ear (HP:0100830)1.78957233
115Systemic lupus erythematosus (HP:0002725)1.77377830
116Premature rupture of membranes (HP:0001788)1.77326007
117Abnormality of macrophages (HP:0004311)1.76917705
118Osteolytic defects of the hand bones (HP:0009699)1.76642599
119Osteolytic defects of the phalanges of the hand (HP:0009771)1.76642599
120Exercise-induced myalgia (HP:0003738)1.76387265
121Turricephaly (HP:0000262)1.75570461
122Flat acetabular roof (HP:0003180)1.75143818
123Abnormality of the corticospinal tract (HP:0002492)1.75133702
124Nasal polyposis (HP:0100582)1.74113098
125Chin dimple (HP:0010751)1.74036898
126Onion bulb formation (HP:0003383)1.73759067
127Hypertriglyceridemia (HP:0002155)1.73372248
128Neuronal loss in central nervous system (HP:0002529)1.73185986
129Hyperextensible skin (HP:0000974)1.72319113
130Abnormality of the Achilles tendon (HP:0005109)1.71446712
131Stridor (HP:0010307)1.69894912
132Mitral stenosis (HP:0001718)1.69132777
133Laryngomalacia (HP:0001601)1.67966878
134Arterial tortuosity (HP:0005116)1.67500605
135Chronic otitis media (HP:0000389)1.67204370
136Absent hand (HP:0004050)1.66431278
137Acanthosis nigricans (HP:0000956)1.66315079
138Persistence of primary teeth (HP:0006335)1.66266520
139Mutism (HP:0002300)1.65445363
140Biconcave vertebral bodies (HP:0004586)1.65430823
141Segmental peripheral demyelination/remyelination (HP:0003481)1.65421285
142Difficulty running (HP:0009046)1.65406553
143Prolonged bleeding time (HP:0003010)1.64989253
144Urethral obstruction (HP:0000796)1.64731169
145Bowing of the arm (HP:0006488)1.63887271
146Bowed forearm bones (HP:0003956)1.63887271
147Vascular tortuosity (HP:0004948)1.62903754
148Overgrowth (HP:0001548)1.62525071
149Mucopolysacchariduria (HP:0008155)1.62294080
150Urinary glycosaminoglycan excretion (HP:0003541)1.62294080
151Soft skin (HP:0000977)1.62242803
152Bulbar palsy (HP:0001283)1.62128200
153Aplasia/Hypoplasia of the spleen (HP:0010451)1.61878123
154Elevated erythrocyte sedimentation rate (HP:0003565)1.61701356
155Bilateral microphthalmos (HP:0007633)1.61259589
156Foot dorsiflexor weakness (HP:0009027)1.60455816
157Striae distensae (HP:0001065)1.60146451
158Fused cervical vertebrae (HP:0002949)1.59971172
159Metabolic alkalosis (HP:0200114)1.58851176
160Coronal craniosynostosis (HP:0004440)1.58596712
161Achilles tendon contracture (HP:0001771)1.58385995
162Gastrointestinal atresia (HP:0002589)1.57535816
163Hypokalemic alkalosis (HP:0001949)1.55837018
164Cellulitis (HP:0100658)1.54923824
165Lower limb asymmetry (HP:0100559)1.53913793
166Broad metatarsal (HP:0001783)1.53328045
167Anteriorly placed anus (HP:0001545)1.53157711
168Abnormality of the axillary hair (HP:0100134)1.52229300
169Abnormality of secondary sexual hair (HP:0009888)1.52229300
170Infantile muscular hypotonia (HP:0008947)1.51164629
171Akinesia (HP:0002304)1.50871868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.12416821
2EPHB13.07312104
3SIK12.88634213
4TGFBR22.79718816
5PRPF4B2.57730700
6TRIB31.94989117
7MAP4K11.94932879
8RIPK11.76374348
9MAP2K31.76225590
10SMG11.72613194
11STK101.70985498
12CLK11.69786219
13MST41.69682092
14PRKD21.68072616
15MAP3K101.67489068
16SIK21.62100172
17ICK1.56237458
18GRK71.54773410
19MAP3K31.54038449
20MATK1.50390030
21CSK1.50243729
22FGR1.47994061
23CDC42BPA1.47212789
24GRK61.47113576
25HIPK21.47025468
26FES1.41919563
27MARK21.41892778
28BLK1.40018747
29FGFR41.37125376
30MAP3K61.36255542
31BMX1.34929517
32IRAK31.29580147
33TESK11.27960698
34MOS1.25555576
35PDGFRA1.23909154
36CSF1R1.22579653
37TBK11.21213276
38NTRK11.17386492
39TNK21.14644252
40DMPK1.14347827
41ERN11.11176747
42UHMK11.11124719
43TYRO31.10253076
44LRRK21.09569177
45NTRK21.08405305
46CASK1.07849342
47STK381.05269753
48MAP2K21.04872047
49MAP3K111.04527988
50RPS6KA21.03860820
51PAK21.02587649
52MST1R1.00773239
53EEF2K1.00389321
54ARAF0.99026532
55LMTK20.98140039
56CAMK1G0.96787983
57PRKD30.95920445
58PKN10.95206971
59PDPK10.94667934
60KSR20.93692863
61GSK3A0.93122406
62MAPK70.90857979
63MYLK0.90253221
64PKN20.89199984
65HCK0.88197039
66TNIK0.87644956
67PRKD10.86151489
68ZAP700.85348347
69GRK50.84511571
70ROCK20.84284226
71TAOK20.83907181
72DYRK1B0.82870229
73IKBKE0.82741176
74TAOK10.82485391
75LATS20.82315337
76DDR20.81872480
77PTK60.81269091
78MAP3K70.81248609
79MTOR0.80222250
80PTK20.79186712
81MAP3K140.79134854
82KIT0.78697620
83JAK10.78289455
84MUSK0.77032242
85CAMKK10.77012983
86LCK0.72750194
87PDGFRB0.72197799
88PAK40.72135915
89CAMK40.68978665
90MAPKAPK50.68687602
91MAP3K130.67348578
92IRAK20.66936324
93CAMK10.65649370
94RPS6KC10.65455388
95RPS6KL10.65455388
96STK110.65423496
97CDK120.65417556
98RET0.64203816
99PRKG20.62670577
100ALK0.62029166
101MAPK120.60538913
102SGK30.59780947
103IRAK40.59645089
104EPHA30.59467727
105PTK2B0.59350429
106CHUK0.59182155
107MAPK40.58622549
108MAP3K10.57621149
109IKBKB0.57595595
110PIM20.57126826
111PHKG20.56582557
112PHKG10.56582557
113EPHB20.56141774
114FGFR20.55770905
115NEK90.55596059
116PDK10.54891582
117FGFR30.54710443
118PRKCH0.54173631
119EPHA20.53927254
120INSR0.53429451
121DAPK30.52923922
122PAK60.52715555
123ITK0.52280862
124TRPM70.52039818
125JAK30.50217916
126CDK50.50154626
127MET0.48803998
128MAP3K20.48518092
129ROCK10.48330561
130MARK10.47868216
131FYN0.47620500
132EGFR0.46840739
133RPS6KA60.46204955
134OXSR10.45971511
135STK390.45640808
136NLK0.45477669
137ABL20.44725347
138TYK20.44698470
139RIPK40.44415725
140DYRK20.44133346
141TTN0.43999248
142LIMK10.42430156
143SIK30.42285595
144MAPKAPK30.40851221

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.07189442
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.07177648
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03929752
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.94228874
5B cell receptor signaling pathway_Homo sapiens_hsa046621.59848691
6Renal cell carcinoma_Homo sapiens_hsa052111.43244629
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40717116
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39913545
9Other glycan degradation_Homo sapiens_hsa005111.38030171
10Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37493035
11Notch signaling pathway_Homo sapiens_hsa043301.37174184
12Axon guidance_Homo sapiens_hsa043601.36832136
13Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34551803
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32764102
15Osteoclast differentiation_Homo sapiens_hsa043801.31739961
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.27974753
17Acute myeloid leukemia_Homo sapiens_hsa052211.27920029
18Focal adhesion_Homo sapiens_hsa045101.26504974
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22986869
20Phospholipase D signaling pathway_Homo sapiens_hsa040721.22209653
21Rap1 signaling pathway_Homo sapiens_hsa040151.20418140
22VEGF signaling pathway_Homo sapiens_hsa043701.14980888
23Chronic myeloid leukemia_Homo sapiens_hsa052201.14617822
24Gastric acid secretion_Homo sapiens_hsa049711.11840743
25Salivary secretion_Homo sapiens_hsa049701.11653782
26T cell receptor signaling pathway_Homo sapiens_hsa046601.10871928
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10124888
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09143478
29Dorso-ventral axis formation_Homo sapiens_hsa043201.07868873
30Platelet activation_Homo sapiens_hsa046111.06426030
31Chemokine signaling pathway_Homo sapiens_hsa040621.05519344
32Glioma_Homo sapiens_hsa052141.05248333
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04246606
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03848321
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03364442
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02926569
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01532580
38ECM-receptor interaction_Homo sapiens_hsa045121.01131966
39ErbB signaling pathway_Homo sapiens_hsa040121.01055623
40TNF signaling pathway_Homo sapiens_hsa046681.00695412
41Dilated cardiomyopathy_Homo sapiens_hsa054141.00196603
42Proteoglycans in cancer_Homo sapiens_hsa052051.00176886
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.99733581
44Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98435971
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97199714
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96730973
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.96207249
48Insulin signaling pathway_Homo sapiens_hsa049100.94942858
49Choline metabolism in cancer_Homo sapiens_hsa052310.94939364
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.93815169
51Primary immunodeficiency_Homo sapiens_hsa053400.92540203
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.92276037
53Long-term depression_Homo sapiens_hsa047300.91536438
54MAPK signaling pathway_Homo sapiens_hsa040100.91432301
55Gap junction_Homo sapiens_hsa045400.91039060
56Endocytosis_Homo sapiens_hsa041440.90929838
57Renin secretion_Homo sapiens_hsa049240.90053459
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89630191
59Estrogen signaling pathway_Homo sapiens_hsa049150.89380843
60Ras signaling pathway_Homo sapiens_hsa040140.88980449
61Leishmaniasis_Homo sapiens_hsa051400.88737629
62Insulin resistance_Homo sapiens_hsa049310.88561909
63Adherens junction_Homo sapiens_hsa045200.88184332
64Hepatitis C_Homo sapiens_hsa051600.88038633
65Salmonella infection_Homo sapiens_hsa051320.84606657
66Viral myocarditis_Homo sapiens_hsa054160.84287739
67Bladder cancer_Homo sapiens_hsa052190.84022328
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83376074
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83320567
70Toxoplasmosis_Homo sapiens_hsa051450.83135453
71Wnt signaling pathway_Homo sapiens_hsa043100.82971402
72GnRH signaling pathway_Homo sapiens_hsa049120.82422525
73Glutamatergic synapse_Homo sapiens_hsa047240.82318850
74Complement and coagulation cascades_Homo sapiens_hsa046100.81694852
75Pancreatic cancer_Homo sapiens_hsa052120.81415546
76Melanogenesis_Homo sapiens_hsa049160.80981976
77Amoebiasis_Homo sapiens_hsa051460.80112786
78Pathways in cancer_Homo sapiens_hsa052000.79644374
79Lysosome_Homo sapiens_hsa041420.78312621
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77867312
81Prostate cancer_Homo sapiens_hsa052150.77677048
82Colorectal cancer_Homo sapiens_hsa052100.77456710
83Pertussis_Homo sapiens_hsa051330.77308757
84Nitrogen metabolism_Homo sapiens_hsa009100.77283397
85Basal cell carcinoma_Homo sapiens_hsa052170.76622615
86Shigellosis_Homo sapiens_hsa051310.76470873
87mTOR signaling pathway_Homo sapiens_hsa041500.76133746
88Small cell lung cancer_Homo sapiens_hsa052220.75900935
89Prolactin signaling pathway_Homo sapiens_hsa049170.75620467
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75573558
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75434925
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75009956
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.74933827
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74851168
95Prion diseases_Homo sapiens_hsa050200.74624050
96Serotonergic synapse_Homo sapiens_hsa047260.73877780
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73209770
98Malaria_Homo sapiens_hsa051440.71507454
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71454675
100Oxytocin signaling pathway_Homo sapiens_hsa049210.71357708
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71011512
102AMPK signaling pathway_Homo sapiens_hsa041520.70536822
103Staphylococcus aureus infection_Homo sapiens_hsa051500.70372781
104Tight junction_Homo sapiens_hsa045300.70201981
105Hematopoietic cell lineage_Homo sapiens_hsa046400.69820931
106Hedgehog signaling pathway_Homo sapiens_hsa043400.69495777
107MicroRNAs in cancer_Homo sapiens_hsa052060.68957910
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68549368
109Cocaine addiction_Homo sapiens_hsa050300.68419838
110cAMP signaling pathway_Homo sapiens_hsa040240.66581437
111Hippo signaling pathway_Homo sapiens_hsa043900.66343895
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66170256
113Phagosome_Homo sapiens_hsa041450.65990019
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64439567
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.64159035
116Endometrial cancer_Homo sapiens_hsa052130.64062870
117Inositol phosphate metabolism_Homo sapiens_hsa005620.63778978
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.63673078
119Non-small cell lung cancer_Homo sapiens_hsa052230.63437181
120Protein digestion and absorption_Homo sapiens_hsa049740.62622440
121Hepatitis B_Homo sapiens_hsa051610.62359609
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61698343
123Tuberculosis_Homo sapiens_hsa051520.60730977
124Melanoma_Homo sapiens_hsa052180.60409783
125Influenza A_Homo sapiens_hsa051640.60019427
126Long-term potentiation_Homo sapiens_hsa047200.59966935
127PPAR signaling pathway_Homo sapiens_hsa033200.59373561
128FoxO signaling pathway_Homo sapiens_hsa040680.57438236
129Cholinergic synapse_Homo sapiens_hsa047250.57174960

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