TRIM9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.85367497
2locomotory exploration behavior (GO:0035641)5.49379049
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.47398182
4vocalization behavior (GO:0071625)5.42137591
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.29812436
6ionotropic glutamate receptor signaling pathway (GO:0035235)5.21543594
7synaptic vesicle maturation (GO:0016188)5.07024043
8glutamate secretion (GO:0014047)4.98594074
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.92660993
10glutamate receptor signaling pathway (GO:0007215)4.86258008
11regulation of glutamate receptor signaling pathway (GO:1900449)4.85193884
12* synaptic vesicle exocytosis (GO:0016079)4.82739270
13protein localization to synapse (GO:0035418)4.82038252
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.77142408
15synaptic transmission, glutamatergic (GO:0035249)4.69825978
16regulation of synaptic vesicle exocytosis (GO:2000300)4.56861425
17neuron cell-cell adhesion (GO:0007158)4.54655597
18neurotransmitter-gated ion channel clustering (GO:0072578)4.44432092
19neuronal action potential propagation (GO:0019227)4.43706187
20cellular potassium ion homeostasis (GO:0030007)4.41391522
21regulation of neuronal synaptic plasticity (GO:0048168)4.32220314
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.31985194
23gamma-aminobutyric acid transport (GO:0015812)4.28131537
24axon ensheathment in central nervous system (GO:0032291)4.26765511
25central nervous system myelination (GO:0022010)4.26765511
26exploration behavior (GO:0035640)4.25883294
27neuron-neuron synaptic transmission (GO:0007270)4.24745040
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.18585867
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.16829049
30regulation of synaptic vesicle transport (GO:1902803)4.15328258
31neurotransmitter secretion (GO:0007269)4.12638984
32regulation of synapse structural plasticity (GO:0051823)4.11741817
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02986378
34long-term memory (GO:0007616)4.00476550
35positive regulation of synapse maturation (GO:0090129)3.95343349
36mechanosensory behavior (GO:0007638)3.89783477
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.89213381
38layer formation in cerebral cortex (GO:0021819)3.83254186
39sodium ion export (GO:0071436)3.80415477
40potassium ion import (GO:0010107)3.79523456
41potassium ion homeostasis (GO:0055075)3.79387476
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.77804707
43regulation of synaptic plasticity (GO:0048167)3.71529866
44regulation of postsynaptic membrane potential (GO:0060078)3.70995895
45transmission of nerve impulse (GO:0019226)3.69612133
46dendritic spine morphogenesis (GO:0060997)3.69395694
47postsynaptic membrane organization (GO:0001941)3.68224342
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67787127
49neurotransmitter uptake (GO:0001504)3.66210904
50long-term synaptic potentiation (GO:0060291)3.64869873
51positive regulation of membrane potential (GO:0045838)3.64620482
52neuronal ion channel clustering (GO:0045161)3.63511324
53proline transport (GO:0015824)3.59591957
54neuron recognition (GO:0008038)3.58765082
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.58678104
56L-amino acid import (GO:0043092)3.55650689
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.53912731
58regulation of dendritic spine morphogenesis (GO:0061001)3.53292511
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49939361
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.49821764
61cell communication by electrical coupling (GO:0010644)3.49727719
62presynaptic membrane assembly (GO:0097105)3.48817121
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47725279
64C4-dicarboxylate transport (GO:0015740)3.46640075
65synaptic vesicle endocytosis (GO:0048488)3.42936429
66neurotransmitter transport (GO:0006836)3.42464914
67acidic amino acid transport (GO:0015800)3.41059313
68response to histamine (GO:0034776)3.40439243
69axonal fasciculation (GO:0007413)3.38607806
70dendrite morphogenesis (GO:0048813)3.38388038
71response to auditory stimulus (GO:0010996)3.37109641
72auditory behavior (GO:0031223)3.35538250
73innervation (GO:0060384)3.33773426
74behavioral fear response (GO:0001662)3.31579283
75behavioral defense response (GO:0002209)3.31579283
76regulation of neurotransmitter secretion (GO:0046928)3.30684872
77cerebellar granule cell differentiation (GO:0021707)3.29392067
78cerebellar Purkinje cell differentiation (GO:0021702)3.26485840
79cellular sodium ion homeostasis (GO:0006883)3.26076564
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23967599
81regulation of voltage-gated calcium channel activity (GO:1901385)3.21465908
82regulation of neurotransmitter levels (GO:0001505)3.18529898
83presynaptic membrane organization (GO:0097090)3.18343845
84positive regulation of dendritic spine morphogenesis (GO:0061003)3.18123390
85learning (GO:0007612)3.17954699
86regulation of synapse maturation (GO:0090128)3.17764137
87neuromuscular process controlling balance (GO:0050885)3.17371089
88positive regulation of dendritic spine development (GO:0060999)3.17080129
89positive regulation of neurotransmitter secretion (GO:0001956)3.15862716
90membrane depolarization (GO:0051899)3.15781168
91membrane depolarization during action potential (GO:0086010)3.15763680
92fear response (GO:0042596)3.14752432
93establishment of mitochondrion localization (GO:0051654)3.12851723
94pyrimidine nucleobase catabolic process (GO:0006208)3.08165656
95regulation of dendritic spine development (GO:0060998)3.06555276
96regulation of neurotransmitter transport (GO:0051588)3.05147049
97regulation of synaptic transmission (GO:0050804)3.04863776
98detection of calcium ion (GO:0005513)3.03552577
99adult walking behavior (GO:0007628)3.02977139
100startle response (GO:0001964)3.02631997
101positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02550707
102neuromuscular synaptic transmission (GO:0007274)3.02491494
103cell differentiation in hindbrain (GO:0021533)3.02429946
104synapse assembly (GO:0007416)3.01564866
105cell migration in hindbrain (GO:0021535)3.00484983
106regulation of respiratory system process (GO:0044065)3.00356812
107L-glutamate transport (GO:0015813)3.00209590
108synaptic transmission (GO:0007268)2.99613652
109positive regulation of synaptic transmission (GO:0050806)2.99558777
110cerebellar Purkinje cell layer development (GO:0021680)2.99398394
111activation of protein kinase A activity (GO:0034199)2.98926767
112dendritic spine organization (GO:0097061)2.98788033
113membrane hyperpolarization (GO:0060081)2.97691128
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97084782
115prepulse inhibition (GO:0060134)2.96869991
116long term synaptic depression (GO:0060292)2.96037885
117amino acid import (GO:0043090)2.95933541
118positive regulation of neurotransmitter transport (GO:0051590)2.94040233
119neuromuscular process controlling posture (GO:0050884)2.93679226
120positive regulation of synapse assembly (GO:0051965)2.93364452
121central nervous system projection neuron axonogenesis (GO:0021952)2.92736948
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.92247597
123negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91176905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.38561544
2GBX2_23144817_ChIP-Seq_PC3_Human3.79430350
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14176140
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12335431
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07892859
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68701949
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68701949
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65402439
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64837154
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60554989
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.60085345
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50797866
13DROSHA_22980978_ChIP-Seq_HELA_Human2.50435913
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.50195888
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49593773
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43218902
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.43177735
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.38477656
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.22719989
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.20440163
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17682676
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16850079
23AR_21572438_ChIP-Seq_LNCaP_Human2.07710816
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03643422
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.02641801
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84564473
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83026791
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80357229
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78078020
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76099353
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75955855
32SMAD4_21799915_ChIP-Seq_A2780_Human1.67405424
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57935394
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57573820
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53188374
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52603638
37TAF15_26573619_Chip-Seq_HEK293_Human1.51103280
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49837732
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47184369
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.43101991
41P300_19829295_ChIP-Seq_ESCs_Human1.42240967
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40965952
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.40203342
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.37830410
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.37465737
46AR_25329375_ChIP-Seq_VCAP_Human1.34489637
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.33782723
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33675160
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33286767
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.31660006
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.30780855
52ZNF274_21170338_ChIP-Seq_K562_Hela1.28644808
53STAT3_23295773_ChIP-Seq_U87_Human1.27281723
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26109981
55AR_19668381_ChIP-Seq_PC3_Human1.24689001
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19571442
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19451316
58TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17755530
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17263723
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14696641
61LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13840389
62* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12384868
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11892066
64TCF4_23295773_ChIP-Seq_U87_Human1.11839828
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11468149
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11376350
67TP53_16413492_ChIP-PET_HCT116_Human1.10505246
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.09793953
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09449479
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09449479
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09392392
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.09113407
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08358864
74FUS_26573619_Chip-Seq_HEK293_Human1.08018947
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07970708
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06731795
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06688861
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06637439
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06245512
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06208353
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.03639973
82AHR_22903824_ChIP-Seq_MCF-7_Human1.02292815
83RNF2_27304074_Chip-Seq_NSC_Mouse1.01825490
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01540708
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.01151327
86SOX9_26525672_Chip-Seq_HEART_Mouse1.01084501
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00347913
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99813426
89RUNX2_22187159_ChIP-Seq_PCA_Human0.99748114
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99553649
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99491835
92TP53_18474530_ChIP-ChIP_U2OS_Human0.98210370
93IGF1R_20145208_ChIP-Seq_DFB_Human0.97478481
94BCAT_22108803_ChIP-Seq_LS180_Human0.97324111
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97323834
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.96489237
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95639759
98RXR_22108803_ChIP-Seq_LS180_Human0.95454372
99* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94544640
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94492433
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92990079
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92427696
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.92192019
104* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91820180
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91495115
106NANOG_18555785_Chip-Seq_ESCs_Mouse0.91438857
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.91316302
108* JUN_21703547_ChIP-Seq_K562_Human0.90992593
109KDM2B_26808549_Chip-Seq_REH_Human0.90763397
110* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90737267
111CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87494656
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86531804
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85774988
114KDM2B_26808549_Chip-Seq_K562_Human0.85698436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.59929013
2MP0003880_abnormal_central_pattern4.77598972
3MP0003635_abnormal_synaptic_transmissio4.20474075
4MP0004270_analgesia3.53337138
5MP0009745_abnormal_behavioral_response3.49147233
6MP0002063_abnormal_learning/memory/cond3.41257964
7MP0002064_seizures3.16838525
8MP0009046_muscle_twitch3.05657473
9MP0001968_abnormal_touch/_nociception3.04184498
10MP0002572_abnormal_emotion/affect_behav2.90828549
11MP0005423_abnormal_somatic_nervous2.82007045
12MP0001486_abnormal_startle_reflex2.74600098
13MP0002272_abnormal_nervous_system2.56930574
14MP0002736_abnormal_nociception_after2.50396564
15MP0002734_abnormal_mechanical_nocicepti2.48837845
16MP0001501_abnormal_sleep_pattern2.38792743
17MP0001440_abnormal_grooming_behavior2.31705541
18MP0002735_abnormal_chemical_nociception2.28885415
19MP0002822_catalepsy2.20369331
20MP0002067_abnormal_sensory_capabilities2.06382585
21MP0008569_lethality_at_weaning1.99185106
22MP0004858_abnormal_nervous_system1.97641249
23MP0002733_abnormal_thermal_nociception1.97049982
24MP0009780_abnormal_chondrocyte_physiolo1.96041851
25MP0005646_abnormal_pituitary_gland1.91691123
26MP0000778_abnormal_nervous_system1.90091629
27MP0001970_abnormal_pain_threshold1.88221072
28MP0003329_amyloid_beta_deposits1.85035350
29MP0002557_abnormal_social/conspecific_i1.82656283
30MP0001984_abnormal_olfaction1.72161781
31MP0002184_abnormal_innervation1.70803191
32MP0001502_abnormal_circadian_rhythm1.66485973
33MP0004924_abnormal_behavior1.62071405
34MP0005386_behavior/neurological_phenoty1.62071405
35MP0004885_abnormal_endolymph1.60678893
36MP0002909_abnormal_adrenal_gland1.56981230
37MP0004811_abnormal_neuron_physiology1.55493151
38MP0003879_abnormal_hair_cell1.50017077
39MP0000955_abnormal_spinal_cord1.49975687
40MP0002882_abnormal_neuron_morphology1.43769639
41MP0003787_abnormal_imprinting1.40819096
42MP0002066_abnormal_motor_capabilities/c1.38051341
43MP0003633_abnormal_nervous_system1.37725214
44MP0006276_abnormal_autonomic_nervous1.36155847
45MP0004142_abnormal_muscle_tone1.33740709
46MP0005645_abnormal_hypothalamus_physiol1.27440077
47MP0000566_synostosis1.25751160
48MP0001188_hyperpigmentation1.25048285
49MP0005551_abnormal_eye_electrophysiolog1.24762368
50MP0001529_abnormal_vocalization1.24024454
51MP0003690_abnormal_glial_cell1.21253232
52MP0003631_nervous_system_phenotype1.17634728
53MP0002152_abnormal_brain_morphology1.16145175
54MP0001905_abnormal_dopamine_level1.16019108
55MP0003136_yellow_coat_color1.01490028
56MP0002653_abnormal_ependyma_morphology1.01445928
57MP0003121_genomic_imprinting0.99655770
58MP0002229_neurodegeneration0.96135485
59MP0002638_abnormal_pupillary_reflex0.95104132
60MP0004145_abnormal_muscle_electrophysio0.95094556
61MP0001177_atelectasis0.94429137
62MP0003634_abnormal_glial_cell0.94299706
63MP0001485_abnormal_pinna_reflex0.93842204
64MP0003075_altered_response_to0.92173370
65MP0004215_abnormal_myocardial_fiber0.92017906
66MP0002069_abnormal_eating/drinking_beha0.91543226
67MP0003123_paternal_imprinting0.90849023
68MP0003632_abnormal_nervous_system0.90224520
69MP0001963_abnormal_hearing_physiology0.89816978
70MP0000579_abnormal_nail_morphology0.89770568
71MP0002090_abnormal_vision0.88690179
72MP0008872_abnormal_physiological_respon0.87957767
73MP0000751_myopathy0.86808129
74MP0004742_abnormal_vestibular_system0.85672698
75MP0003122_maternal_imprinting0.84615796
76MP0008961_abnormal_basal_metabolism0.84211565
77MP0000631_abnormal_neuroendocrine_gland0.82897768
78MP0008874_decreased_physiological_sensi0.82840660
79MP0005171_absent_coat_pigmentation0.81035793
80MP0004085_abnormal_heartbeat0.80288652
81MP0002752_abnormal_somatic_nervous0.79342345
82MP0000569_abnormal_digit_pigmentation0.78968238
83MP0003137_abnormal_impulse_conducting0.78649978
84MP0005167_abnormal_blood-brain_barrier0.78116415
85MP0000604_amyloidosis0.76430545
86MP0010386_abnormal_urinary_bladder0.74658006
87MP0005394_taste/olfaction_phenotype0.73500748
88MP0005499_abnormal_olfactory_system0.73500748
89MP0001986_abnormal_taste_sensitivity0.73491784
90MP0005535_abnormal_body_temperature0.72728472
91MP0003183_abnormal_peptide_metabolism0.71929270
92MP0002876_abnormal_thyroid_physiology0.71797771
93MP0005409_darkened_coat_color0.67919697
94MP0005187_abnormal_penis_morphology0.67919212
95MP0004043_abnormal_pH_regulation0.67627660
96MP0002249_abnormal_larynx_morphology0.67583460
97MP0006292_abnormal_olfactory_placode0.67112567
98MP0000920_abnormal_myelination0.66452959
99MP0006072_abnormal_retinal_apoptosis0.65778650
100MP0001299_abnormal_eye_distance/0.63880135
101MP0004484_altered_response_of0.63804924
102MP0000026_abnormal_inner_ear0.62835804
103MP0004233_abnormal_muscle_weight0.62412427
104MP0010769_abnormal_survival0.61862777
105MP0010770_preweaning_lethality0.61516342
106MP0002082_postnatal_lethality0.61516342
107MP0001664_abnormal_digestion0.61145483
108MP0003861_abnormal_nervous_system0.60480283
109MP0002234_abnormal_pharynx_morphology0.60120523
110MP0005253_abnormal_eye_physiology0.60021652
111MP0000013_abnormal_adipose_tissue0.58545772
112MP0010768_mortality/aging0.58333997
113MP0002837_dystrophic_cardiac_calcinosis0.55968701
114MP0001943_abnormal_respiration0.54613025
115MP0003283_abnormal_digestive_organ0.54611541
116MP0005195_abnormal_posterior_eye0.54596146
117MP0003938_abnormal_ear_development0.54077580

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.22303968
2Myokymia (HP:0002411)6.51836612
3Focal seizures (HP:0007359)5.79444449
4Epileptic encephalopathy (HP:0200134)5.46574842
5Visual hallucinations (HP:0002367)4.95106121
6Progressive cerebellar ataxia (HP:0002073)4.88800155
7Febrile seizures (HP:0002373)4.65376757
8Atonic seizures (HP:0010819)4.47388272
9Absence seizures (HP:0002121)4.07438865
10Generalized tonic-clonic seizures (HP:0002069)3.94185494
11Dialeptic seizures (HP:0011146)3.89184448
12Hyperventilation (HP:0002883)3.85356178
13Broad-based gait (HP:0002136)3.83493053
14Action tremor (HP:0002345)3.82216836
15Gaze-evoked nystagmus (HP:0000640)3.63061780
16Dysdiadochokinesis (HP:0002075)3.54922232
17Hemiparesis (HP:0001269)3.30711963
18Supranuclear gaze palsy (HP:0000605)3.23933701
19Dysmetria (HP:0001310)3.22459814
20Genetic anticipation (HP:0003743)3.20262290
21Megalencephaly (HP:0001355)3.14313251
22Truncal ataxia (HP:0002078)3.12241660
23Poor eye contact (HP:0000817)3.11684231
24Diplopia (HP:0000651)3.10203889
25Abnormality of binocular vision (HP:0011514)3.10203889
26Impaired vibration sensation in the lower limbs (HP:0002166)3.04658487
27Depression (HP:0000716)2.97113446
28Hemiplegia (HP:0002301)2.97068536
29Split foot (HP:0001839)2.96343853
30Amblyopia (HP:0000646)2.89423676
31Abnormal eating behavior (HP:0100738)2.88271090
32Impaired smooth pursuit (HP:0007772)2.85491550
33Postural instability (HP:0002172)2.85276016
34Scanning speech (HP:0002168)2.84675063
35Impaired social interactions (HP:0000735)2.80381087
36Abnormal social behavior (HP:0012433)2.80381087
37Anxiety (HP:0000739)2.79981688
38Excessive salivation (HP:0003781)2.79859159
39Drooling (HP:0002307)2.79859159
40Epileptiform EEG discharges (HP:0011182)2.77014268
41Urinary bladder sphincter dysfunction (HP:0002839)2.66965731
42Ankle clonus (HP:0011448)2.64299649
43Abnormality of the corticospinal tract (HP:0002492)2.63070391
44Neurofibrillary tangles (HP:0002185)2.61799325
45Status epilepticus (HP:0002133)2.61173782
46Aplasia of the phalanges of the hand (HP:0009802)2.59336068
47Aplasia involving bones of the extremities (HP:0009825)2.59336068
48Aplasia involving bones of the upper limbs (HP:0009823)2.59336068
49Cerebral inclusion bodies (HP:0100314)2.55869649
50Stereotypic behavior (HP:0000733)2.55443322
51Peripheral hypomyelination (HP:0007182)2.52165085
52EEG with generalized epileptiform discharges (HP:0011198)2.49434250
53Abnormality of ocular smooth pursuit (HP:0000617)2.49228637
54Abnormality of the lower motor neuron (HP:0002366)2.43009813
55Absent speech (HP:0001344)2.37488901
56Bradykinesia (HP:0002067)2.35028559
57Hypsarrhythmia (HP:0002521)2.31099508
58Mutism (HP:0002300)2.30905920
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.28678876
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.28678876
61Intention tremor (HP:0002080)2.26122330
62Dysmetric saccades (HP:0000641)2.25194548
63Sleep apnea (HP:0010535)2.25027713
64Protruding tongue (HP:0010808)2.23210473
65Spastic gait (HP:0002064)2.17794753
66Spastic tetraparesis (HP:0001285)2.14331111
67Impaired vibratory sensation (HP:0002495)2.13679068
68Akinesia (HP:0002304)2.13142828
69Generalized myoclonic seizures (HP:0002123)2.12691048
70Torticollis (HP:0000473)2.12036397
71Urinary urgency (HP:0000012)2.10271275
72Increased circulating renin level (HP:0000848)2.09299698
73Papilledema (HP:0001085)2.08220598
74Blue irides (HP:0000635)2.07557543
75Tetraplegia (HP:0002445)2.06017116
76Cerebral hypomyelination (HP:0006808)2.05862723
77Progressive inability to walk (HP:0002505)2.05483525
78Focal dystonia (HP:0004373)2.05281785
79Polyphagia (HP:0002591)2.04134500
80Morphological abnormality of the pyramidal tract (HP:0002062)1.98520489
81Clumsiness (HP:0002312)1.98188051
82Abnormality of the diencephalon (HP:0010662)1.97284564
83Fetal akinesia sequence (HP:0001989)1.96037847
84Incomplete penetrance (HP:0003829)1.96031146
85Insomnia (HP:0100785)1.91330088
86Gait ataxia (HP:0002066)1.90527982
87Inability to walk (HP:0002540)1.90345284
88Lower limb muscle weakness (HP:0007340)1.90286855
89Abnormality of salivation (HP:0100755)1.87700324
90Hypoplasia of the corpus callosum (HP:0002079)1.86715193
91Ventricular fibrillation (HP:0001663)1.85832169
92Thickened helices (HP:0000391)1.82740020
93Gait imbalance (HP:0002141)1.82589537
94Obstructive sleep apnea (HP:0002870)1.81293309
95Annular pancreas (HP:0001734)1.80863593
96Spastic tetraplegia (HP:0002510)1.80224160
97Retinal dysplasia (HP:0007973)1.80208286
98Decreased circulating renin level (HP:0003351)1.76931658
99Clonus (HP:0002169)1.76926765
100Psychosis (HP:0000709)1.75076956
101Confusion (HP:0001289)1.74927436
102Abnormality of saccadic eye movements (HP:0000570)1.74027983
103Limb dystonia (HP:0002451)1.73934615
104Esotropia (HP:0000565)1.73532255
105Agitation (HP:0000713)1.73093388
106Postural tremor (HP:0002174)1.73051309
107Oligodactyly (hands) (HP:0001180)1.72577289
108Amyotrophic lateral sclerosis (HP:0007354)1.72556591
109Pointed chin (HP:0000307)1.72435932
110Specific learning disability (HP:0001328)1.71225999
111Craniofacial dystonia (HP:0012179)1.69834686
112Rigidity (HP:0002063)1.68590829
113Hypoglycemic seizures (HP:0002173)1.66417373
114Neuronal loss in central nervous system (HP:0002529)1.65965607
115Heterochromia iridis (HP:0001100)1.65921587
116Deeply set eye (HP:0000490)1.64661723
117Narrow nasal bridge (HP:0000446)1.64193191
118Limb ataxia (HP:0002070)1.63839335
119Insidious onset (HP:0003587)1.63012435
120Termporal pattern (HP:0011008)1.63012435
121Abnormal EKG (HP:0003115)1.62681547
122Lower limb asymmetry (HP:0100559)1.62101267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.28171783
2NTRK34.73462949
3MAP3K93.16371291
4MAP3K42.85821724
5TNIK2.68457803
6MARK12.56986478
7MAP2K72.55029952
8NTRK22.48003948
9MINK12.39352897
10CASK2.35947879
11DAPK22.30364637
12PAK62.07810269
13RIPK41.98928463
14PRKD31.92960621
15KSR21.71251700
16MAP2K41.66576654
17KSR11.66351259
18PLK21.66137022
19PRPF4B1.61239488
20CAMKK11.59556744
21MAPK131.58426418
22DAPK11.53648744
23NTRK11.51338509
24MAP3K121.51210724
25CDK51.49543154
26FGFR21.33144264
27PRKCG1.31893280
28SIK21.30043466
29PKN11.26616877
30PHKG21.25174632
31PHKG11.25174632
32FES1.24227784
33CAMKK21.22683443
34STK381.22652841
35CDK191.22383388
36GRK51.19392746
37PNCK1.17867773
38CAMK2A1.12868969
39MAP3K131.12078565
40TYRO31.08210328
41SGK21.05023073
42CAMK2B1.02322024
43SGK4941.01985092
44SGK2231.01985092
45ARAF0.99640084
46MARK20.98802610
47CAMK10.97515588
48LMTK20.94378454
49DYRK1A0.87915128
50UHMK10.87714488
51BMPR20.87505004
52MAP3K20.87349518
53CSNK1G30.86052210
54CDK180.85455444
55DYRK20.84209324
56BRSK10.84157359
57CDK150.84013290
58FRK0.83302873
59PTK2B0.82845294
60CSNK1A1L0.82583177
61SGK30.81542418
62SGK10.81288555
63CDK140.78774110
64ROCK20.77933305
65PINK10.77115949
66STK110.76228497
67MUSK0.75690059
68CSNK1G10.74145986
69CSNK1G20.73656538
70RAF10.72623494
71CDK11A0.72330340
72ERBB20.71241060
73RIPK10.69134248
74PAK30.66895188
75OXSR10.66715875
76INSRR0.66495575
77PRKCH0.64510841
78FGR0.62896935
79PRKCE0.62700493
80MAPKAPK50.62083113
81MAP3K60.60230572
82NEK60.59960309
83RET0.59383099
84CDC42BPA0.58209289
85WNK10.57707400
86MAP4K20.57393813
87CAMK1G0.56224312
88TAOK10.55573978
89CAMK2D0.55559186
90WEE10.54780289
91PDK10.53674014
92CAMK2G0.53129394
93PDPK10.52764202
94TNK20.52323645
95LATS20.51969397
96RPS6KA30.51882228
97DMPK0.51695137
98MAP3K70.51523509
99AKT30.48966287
100NME10.47818620
101CAMK40.45251725
102CSNK1D0.45003588
103TAOK20.43794903
104CCNB10.43345425
105PRKCZ0.43245412
106CDK30.42428517
107MAPK120.41751126
108MAPK100.41353101
109FYN0.41157130
110CSNK1A10.40642513
111ROCK10.39799481
112SIK30.39557582
113FER0.38308322
114BCR0.37208648
115MAP3K10.36866600
116MAPK150.35691341
117PRKCA0.35163131
118LIMK10.34930970
119PRKCB0.33667773
120PRKG10.33667410
121WNK30.33072769
122PRKACA0.32995228
123STK390.32727965
124ALK0.32618467
125PRKDC0.32010182
126CSNK1E0.28705687
127GSK3B0.28073241
128EPHB20.27771147

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.15518069
2Synaptic vesicle cycle_Homo sapiens_hsa047212.94705520
3Circadian entrainment_Homo sapiens_hsa047132.88117815
4Glutamatergic synapse_Homo sapiens_hsa047242.84842441
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81654913
6GABAergic synapse_Homo sapiens_hsa047272.78032961
7Long-term potentiation_Homo sapiens_hsa047202.77095016
8Olfactory transduction_Homo sapiens_hsa047402.62269121
9Morphine addiction_Homo sapiens_hsa050322.60831930
10Amphetamine addiction_Homo sapiens_hsa050312.54148605
11Salivary secretion_Homo sapiens_hsa049702.27366723
12Insulin secretion_Homo sapiens_hsa049112.13870978
13Dopaminergic synapse_Homo sapiens_hsa047282.07636309
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07220747
15Gastric acid secretion_Homo sapiens_hsa049711.89667191
16Taste transduction_Homo sapiens_hsa047421.88371767
17Cholinergic synapse_Homo sapiens_hsa047251.83388254
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82588009
19Long-term depression_Homo sapiens_hsa047301.75464999
20Calcium signaling pathway_Homo sapiens_hsa040201.72190528
21Serotonergic synapse_Homo sapiens_hsa047261.69880453
22Cocaine addiction_Homo sapiens_hsa050301.67541966
23Renin secretion_Homo sapiens_hsa049241.67181711
24Oxytocin signaling pathway_Homo sapiens_hsa049211.63622047
25Nitrogen metabolism_Homo sapiens_hsa009101.63506062
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56843012
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52743612
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47543422
29cAMP signaling pathway_Homo sapiens_hsa040241.38570569
30Vitamin B6 metabolism_Homo sapiens_hsa007501.38009213
31GnRH signaling pathway_Homo sapiens_hsa049121.38001750
32Gap junction_Homo sapiens_hsa045401.25037950
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22795157
34Collecting duct acid secretion_Homo sapiens_hsa049661.21579963
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21205403
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17868076
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14028000
38Type II diabetes mellitus_Homo sapiens_hsa049301.11275281
39Axon guidance_Homo sapiens_hsa043601.09201877
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07634589
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05397812
42Estrogen signaling pathway_Homo sapiens_hsa049151.04650039
43Melanogenesis_Homo sapiens_hsa049161.02588943
44Glioma_Homo sapiens_hsa052141.02126791
45Pancreatic secretion_Homo sapiens_hsa049720.96497891
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95326560
47Circadian rhythm_Homo sapiens_hsa047100.93473466
48ErbB signaling pathway_Homo sapiens_hsa040120.93271571
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.91674348
50Cardiac muscle contraction_Homo sapiens_hsa042600.91012321
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87074553
52Dorso-ventral axis formation_Homo sapiens_hsa043200.86968848
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.85849775
54Phototransduction_Homo sapiens_hsa047440.82480451
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79960602
56Thyroid hormone synthesis_Homo sapiens_hsa049180.79702358
57beta-Alanine metabolism_Homo sapiens_hsa004100.76515879
58Choline metabolism in cancer_Homo sapiens_hsa052310.74410531
59Dilated cardiomyopathy_Homo sapiens_hsa054140.72374132
60Butanoate metabolism_Homo sapiens_hsa006500.71855523
61Vibrio cholerae infection_Homo sapiens_hsa051100.71667207
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69495861
63Fatty acid biosynthesis_Homo sapiens_hsa000610.68299018
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68022076
65Oocyte meiosis_Homo sapiens_hsa041140.66380620
66MAPK signaling pathway_Homo sapiens_hsa040100.65388017
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64786231
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62103396
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59546501
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58033693
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57701963
72Bile secretion_Homo sapiens_hsa049760.57652815
73Glucagon signaling pathway_Homo sapiens_hsa049220.57562397
74Ras signaling pathway_Homo sapiens_hsa040140.55748886
75Rap1 signaling pathway_Homo sapiens_hsa040150.55740442
76Inositol phosphate metabolism_Homo sapiens_hsa005620.53778845
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53541268
78Regulation of autophagy_Homo sapiens_hsa041400.53420639
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53235718
80African trypanosomiasis_Homo sapiens_hsa051430.51269195
81VEGF signaling pathway_Homo sapiens_hsa043700.51253755
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.49984466
83Histidine metabolism_Homo sapiens_hsa003400.47641163
84Wnt signaling pathway_Homo sapiens_hsa043100.47222953
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.46882247
86Arginine and proline metabolism_Homo sapiens_hsa003300.42963153
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41816166
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41792053
89Alcoholism_Homo sapiens_hsa050340.40980719
90Hippo signaling pathway_Homo sapiens_hsa043900.40975663
91Type I diabetes mellitus_Homo sapiens_hsa049400.40832217
92AMPK signaling pathway_Homo sapiens_hsa041520.35842696
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35345139
94mTOR signaling pathway_Homo sapiens_hsa041500.33482158
95Ovarian steroidogenesis_Homo sapiens_hsa049130.33284998
96Mineral absorption_Homo sapiens_hsa049780.32476904
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32297770
98ABC transporters_Homo sapiens_hsa020100.32127099
99Prion diseases_Homo sapiens_hsa050200.31686817
100Non-small cell lung cancer_Homo sapiens_hsa052230.30184880
101Arginine biosynthesis_Homo sapiens_hsa002200.29894172
102Fatty acid metabolism_Homo sapiens_hsa012120.29327202
103Endocytosis_Homo sapiens_hsa041440.29187507
104Endometrial cancer_Homo sapiens_hsa052130.28615622
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.28163050
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.27784244
107Insulin signaling pathway_Homo sapiens_hsa049100.27754967
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27503676
109Propanoate metabolism_Homo sapiens_hsa006400.27340778
110Alzheimers disease_Homo sapiens_hsa050100.26810338
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25402404
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24988909
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24504059
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24293476
115Chemokine signaling pathway_Homo sapiens_hsa040620.23976768

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