TRIML1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K6-linked ubiquitination (GO:0085020)5.04951339
2microtubule depolymerization (GO:0007019)4.86322498
3regulation of helicase activity (GO:0051095)4.66565229
4regulation of posttranscriptional gene silencing (GO:0060147)4.18921428
5regulation of gene silencing by miRNA (GO:0060964)4.18921428
6regulation of gene silencing by RNA (GO:0060966)4.18921428
7nuclear pore organization (GO:0006999)4.17956352
8regulation of nuclear cell cycle DNA replication (GO:0033262)4.16425338
9nuclear pore complex assembly (GO:0051292)4.15213404
10negative regulation of DNA-dependent DNA replication (GO:2000104)4.04612835
11kinetochore assembly (GO:0051382)4.04497663
12kinetochore organization (GO:0051383)3.83402492
13meiotic chromosome segregation (GO:0045132)3.81740682
14reciprocal DNA recombination (GO:0035825)3.81506299
15reciprocal meiotic recombination (GO:0007131)3.81506299
16somatic hypermutation of immunoglobulin genes (GO:0016446)3.75997229
17somatic diversification of immune receptors via somatic mutation (GO:0002566)3.75997229
18DNA strand renaturation (GO:0000733)3.75826165
19DNA replication initiation (GO:0006270)3.64959362
20intra-S DNA damage checkpoint (GO:0031573)3.61879923
21maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.59135950
22DNA double-strand break processing (GO:0000729)3.57605883
23DNA integration (GO:0015074)3.55930338
24mismatch repair (GO:0006298)3.52215720
25chromatin remodeling at centromere (GO:0031055)3.51885302
26determination of adult lifespan (GO:0008340)3.50682358
27single strand break repair (GO:0000012)3.49833124
28female gonad development (GO:0008585)3.46645399
29histone H4-K12 acetylation (GO:0043983)3.40277425
30pore complex assembly (GO:0046931)3.39726366
31replicative senescence (GO:0090399)3.33446001
32positive regulation of DNA-dependent DNA replication (GO:2000105)3.31112195
33mitotic metaphase plate congression (GO:0007080)3.29637102
34negative regulation of telomere maintenance (GO:0032205)3.28946985
35paraxial mesoderm development (GO:0048339)3.28897908
36IMP biosynthetic process (GO:0006188)3.26637991
37regulation of DNA endoreduplication (GO:0032875)3.25632905
38CENP-A containing nucleosome assembly (GO:0034080)3.23717879
39regulation of telomere maintenance via telomerase (GO:0032210)3.19983012
40DNA replication checkpoint (GO:0000076)3.19938359
41centriole assembly (GO:0098534)3.19240620
42regulation of centriole replication (GO:0046599)3.17518222
43regulation of histone H3-K9 methylation (GO:0051570)3.15482512
44replication fork processing (GO:0031297)3.13517507
45negative regulation of androgen receptor signaling pathway (GO:0060766)3.12646685
46telomere maintenance via telomerase (GO:0007004)3.10656675
47cilium or flagellum-dependent cell motility (GO:0001539)3.09641680
48DNA synthesis involved in DNA repair (GO:0000731)3.03798741
49regulation of DNA-dependent DNA replication (GO:0090329)3.02335747
50mitotic sister chromatid segregation (GO:0000070)2.97890346
51tRNA methylation (GO:0030488)2.93902794
52cell wall macromolecule catabolic process (GO:0016998)2.91358743
53cell wall macromolecule metabolic process (GO:0044036)2.91358743
54telomere maintenance via telomere lengthening (GO:0010833)2.90245697
55nucleobase biosynthetic process (GO:0046112)2.88062049
56histone exchange (GO:0043486)2.87974892
57motile cilium assembly (GO:0044458)2.86899696
58DNA methylation involved in gamete generation (GO:0043046)2.83183746
59response to X-ray (GO:0010165)2.82823082
60telomere maintenance (GO:0000723)2.80957589
61synapsis (GO:0007129)2.80532385
62DNA catabolic process, exonucleolytic (GO:0000738)2.80205780
63telomere maintenance via semi-conservative replication (GO:0032201)2.79049936
64metaphase plate congression (GO:0051310)2.78620636
65DNA replication-dependent nucleosome assembly (GO:0006335)2.77261770
66DNA replication-dependent nucleosome organization (GO:0034723)2.77261770
67telomere organization (GO:0032200)2.76807656
68regulation of double-strand break repair via homologous recombination (GO:0010569)2.76799451
69purine nucleobase biosynthetic process (GO:0009113)2.75993529
70RNA-dependent DNA replication (GO:0006278)2.75119336
71epithelial cilium movement (GO:0003351)2.74898977
72DNA replication-independent nucleosome organization (GO:0034724)2.74049315
73DNA replication-independent nucleosome assembly (GO:0006336)2.74049315
74negative regulation of DNA recombination (GO:0045910)2.71747116
75chromosome organization involved in meiosis (GO:0070192)2.71225866
76piRNA metabolic process (GO:0034587)2.70211830
77ribosome biogenesis (GO:0042254)2.68599597
78regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68052226
79regulation of mitotic spindle checkpoint (GO:1903504)2.68052226
80microtubule polymerization or depolymerization (GO:0031109)2.66405959
81DNA strand elongation (GO:0022616)2.66321494
82regulation of DNA damage checkpoint (GO:2000001)2.65021616
83regulation of centrosome cycle (GO:0046605)2.64522191
84telomere maintenance via recombination (GO:0000722)2.63678201
85polyketide metabolic process (GO:0030638)2.62880789
86doxorubicin metabolic process (GO:0044598)2.62880789
87daunorubicin metabolic process (GO:0044597)2.62880789
88DNA strand elongation involved in DNA replication (GO:0006271)2.62083825
89maturation of 5.8S rRNA (GO:0000460)2.61299947
90recombinational repair (GO:0000725)2.60337174
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60244901
92sperm-egg recognition (GO:0035036)2.60134740
93negative regulation of chromosome segregation (GO:0051985)2.57262080
94double-strand break repair via homologous recombination (GO:0000724)2.57169535
95DNA demethylation (GO:0080111)2.55367264
96inner cell mass cell proliferation (GO:0001833)2.55247393
97regulation of centrosome duplication (GO:0010824)2.54391166
98dosage compensation (GO:0007549)2.54364502
99DNA ligation (GO:0006266)2.53968853
100negative regulation of telomerase activity (GO:0051974)2.52351983

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.53390202
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.27593747
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.14257898
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.14257898
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.14257898
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.79147604
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79132397
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.63089624
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.61183416
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.42336403
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36035447
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.34949524
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28316160
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23691286
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21398886
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.17950658
17SOX2_18555785_ChIP-Seq_MESCs_Mouse2.13738840
18POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.13720509
19GBX2_23144817_ChIP-Seq_PC3_Human2.11997438
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.08871872
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.04683623
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.03377598
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03172550
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00227820
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97222593
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95922410
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.94905245
28NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.94863298
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.94224099
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.92085805
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.88336337
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85435439
33TCF3_18692474_ChIP-Seq_MESCs_Mouse1.80906871
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79872541
35* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69012072
36IRF1_19129219_ChIP-ChIP_H3396_Human1.65426366
37SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.61888801
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59380406
39FUS_26573619_Chip-Seq_HEK293_Human1.56719553
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56074536
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47663794
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40205145
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.39541507
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38758772
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.35164948
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33505296
47STAT3_18555785_Chip-Seq_ESCs_Mouse1.30972600
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30495675
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29031563
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29027843
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27524698
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25997432
53E2F1_18555785_Chip-Seq_ESCs_Mouse1.25643196
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25132252
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24849353
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24694165
57KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24286805
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22014369
59EWS_26573619_Chip-Seq_HEK293_Human1.21963158
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.20907835
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19287934
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19116756
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18761273
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18697898
65OCT4_18555785_Chip-Seq_ESCs_Mouse1.18099978
66RNF2_27304074_Chip-Seq_NSC_Mouse1.17020114
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16031733
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.15607092
69POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15357242
70NMYC_18555785_Chip-Seq_ESCs_Mouse1.15322007
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15026285
72P53_22387025_ChIP-Seq_ESCs_Mouse1.14468709
73KLF4_18555785_Chip-Seq_ESCs_Mouse1.13827310
74P300_18555785_Chip-Seq_ESCs_Mouse1.13643276
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13605566
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10961144
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10907258
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10105440
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.09822900
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09225565
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.08983047
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.08022848
83RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07491229
84NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06697355
85ZFX_18555785_Chip-Seq_ESCs_Mouse1.06662226
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05787297
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04879766
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03837024
89ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03784714
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02609936
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02591122
92SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02077825
93VDR_22108803_ChIP-Seq_LS180_Human1.01907908
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01835099
95KAP1_27257070_Chip-Seq_ESCs_Mouse1.01221243
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.00160480
97THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99899295
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.99787788
99TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98410634
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97969205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.10099918
2MP0003136_yellow_coat_color4.01048890
3MP0010094_abnormal_chromosome_stability3.66550760
4MP0006292_abnormal_olfactory_placode3.65216370
5MP0008057_abnormal_DNA_replication3.60805655
6MP0003111_abnormal_nucleus_morphology3.55959667
7MP0001188_hyperpigmentation3.53107164
8MP0003941_abnormal_skin_development2.97321821
9MP0008877_abnormal_DNA_methylation2.95952314
10MP0000566_synostosis2.70987147
11MP0003693_abnormal_embryo_hatching2.67549665
12MP0003787_abnormal_imprinting2.67232262
13MP0004133_heterotaxia2.64606674
14MP0002653_abnormal_ependyma_morphology2.51752791
15MP0003283_abnormal_digestive_organ2.30253661
16MP0003077_abnormal_cell_cycle2.15256830
17MP0005410_abnormal_fertilization2.13379351
18MP0002277_abnormal_respiratory_mucosa2.11641499
19MP0003786_premature_aging1.92145565
20MP0004957_abnormal_blastocyst_morpholog1.80503700
21MP0002210_abnormal_sex_determination1.77945585
22MP0003121_genomic_imprinting1.77419199
23MP0008007_abnormal_cellular_replicative1.68465156
24MP0001293_anophthalmia1.66960822
25MP0003698_abnormal_male_reproductive1.62531280
26MP0001929_abnormal_gametogenesis1.59312145
27MP0002102_abnormal_ear_morphology1.55479751
28MP0003123_paternal_imprinting1.49594593
29MP0005670_abnormal_white_adipose1.47380420
30MP0000516_abnormal_urinary_system1.45900058
31MP0005367_renal/urinary_system_phenotyp1.45900058
32MP0008932_abnormal_embryonic_tissue1.43379347
33MP0001145_abnormal_male_reproductive1.41418552
34MP0000490_abnormal_crypts_of1.40952656
35MP0005171_absent_coat_pigmentation1.39303502
36MP0001986_abnormal_taste_sensitivity1.36587841
37MP0003718_maternal_effect1.34779092
38MP0002132_abnormal_respiratory_system1.28788952
39MP0003890_abnormal_embryonic-extraembry1.26002156
40MP0000015_abnormal_ear_pigmentation1.20546292
41MP0010307_abnormal_tumor_latency1.17657225
42MP0000653_abnormal_sex_gland1.16029279
43MP0005075_abnormal_melanosome_morpholog1.14867684
44MP0010030_abnormal_orbit_morphology1.14406399
45MP0005645_abnormal_hypothalamus_physiol1.13482101
46MP0008789_abnormal_olfactory_epithelium1.08507704
47MP0008260_abnormal_autophagy1.08225593
48MP0005499_abnormal_olfactory_system1.06707983
49MP0005394_taste/olfaction_phenotype1.06707983
50MP0002160_abnormal_reproductive_system1.06336346
51MP0001119_abnormal_female_reproductive1.05025644
52MP0002249_abnormal_larynx_morphology1.04756525
53MP0003878_abnormal_ear_physiology1.03524255
54MP0005377_hearing/vestibular/ear_phenot1.03524255
55MP0003119_abnormal_digestive_system1.01368395
56MP0001286_abnormal_eye_development1.00078214
57MP0005174_abnormal_tail_pigmentation0.97514537
58MP0000026_abnormal_inner_ear0.96479599
59MP0000350_abnormal_cell_proliferation0.95922686
60MP0001186_pigmentation_phenotype0.95111503
61MP0002638_abnormal_pupillary_reflex0.91695258
62MP0002075_abnormal_coat/hair_pigmentati0.89593897
63MP0002085_abnormal_embryonic_tissue0.88786090
64MP0000049_abnormal_middle_ear0.87754390
65MP0002161_abnormal_fertility/fecundity0.86733134
66MP0005646_abnormal_pituitary_gland0.83903385
67MP0003315_abnormal_perineum_morphology0.83172353
68MP0005389_reproductive_system_phenotype0.82667533
69MP0003936_abnormal_reproductive_system0.81993998
70MP0008995_early_reproductive_senescence0.81312772
71MP0009697_abnormal_copulation0.79919497
72MP0000631_abnormal_neuroendocrine_gland0.79224391
73MP0002084_abnormal_developmental_patter0.78043636
74MP0005380_embryogenesis_phenotype0.77647504
75MP0001672_abnormal_embryogenesis/_devel0.77647504
76MP0004197_abnormal_fetal_growth/weight/0.76745909
77MP0004142_abnormal_muscle_tone0.76228900
78MP0000432_abnormal_head_morphology0.76093665
79MP0002938_white_spotting0.76048879
80MP0005253_abnormal_eye_physiology0.76031635
81MP0000371_diluted_coat_color0.75278577
82MP0006072_abnormal_retinal_apoptosis0.75063697
83MP0002396_abnormal_hematopoietic_system0.74559802
84MP0001346_abnormal_lacrimal_gland0.74459534
85MP0001963_abnormal_hearing_physiology0.73451158
86MP0003806_abnormal_nucleotide_metabolis0.72433296
87MP0005409_darkened_coat_color0.70977700
88MP0000470_abnormal_stomach_morphology0.70344334
89MP0000569_abnormal_digit_pigmentation0.69672535
90MP0005391_vision/eye_phenotype0.68550965
91MP0001984_abnormal_olfaction0.67738440
92MP0003861_abnormal_nervous_system0.67491008
93MP0000313_abnormal_cell_death0.65519317
94MP0005647_abnormal_sex_gland0.64111841
95MP0002233_abnormal_nose_morphology0.63443207
96MP0002095_abnormal_skin_pigmentation0.62695028
97MP0005623_abnormal_meninges_morphology0.62613448
98MP0003938_abnormal_ear_development0.62532718
99MP0003755_abnormal_palate_morphology0.62330768
100MP0002697_abnormal_eye_size0.62253384

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.48906757
2Chromsome breakage (HP:0040012)5.93544005
3Aplasia/Hypoplasia of the uvula (HP:0010293)3.94787295
4Abnormality of the labia minora (HP:0012880)3.90528777
5Meckel diverticulum (HP:0002245)3.83977719
6Abnormality of the ileum (HP:0001549)3.75990486
7Abnormality of the preputium (HP:0100587)3.63461042
8Supernumerary spleens (HP:0009799)3.61263378
9Birth length less than 3rd percentile (HP:0003561)3.50642204
10Abnormality of chromosome stability (HP:0003220)3.37465688
11Duplicated collecting system (HP:0000081)3.34033540
12Septo-optic dysplasia (HP:0100842)3.21761306
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.14849478
14Abnormality of the renal collecting system (HP:0004742)3.13813594
15Ectopic kidney (HP:0000086)3.03740391
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.89346480
17Absent/shortened dynein arms (HP:0200106)2.89346480
18Absent radius (HP:0003974)2.88941937
19Prostate neoplasm (HP:0100787)2.78374673
20Clubbing of toes (HP:0100760)2.77742314
21Aplasia involving forearm bones (HP:0009822)2.75689346
22Absent forearm bone (HP:0003953)2.75689346
23Small intestinal stenosis (HP:0012848)2.72864567
24Duodenal stenosis (HP:0100867)2.72864567
25Impulsivity (HP:0100710)2.69018215
26Abnormality of DNA repair (HP:0003254)2.62121300
27Median cleft lip (HP:0000161)2.56593639
28Abnormality of the carotid arteries (HP:0005344)2.55746114
29Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.51844892
30Nephroblastoma (Wilms tumor) (HP:0002667)2.48597584
31Optic nerve hypoplasia (HP:0000609)2.47973891
32Intestinal atresia (HP:0011100)2.42355945
33Agnosia (HP:0010524)2.42017562
34Absent thumb (HP:0009777)2.40742987
35Febrile seizures (HP:0002373)2.40651629
36Abnormality of abdominal situs (HP:0011620)2.38531943
37Abdominal situs inversus (HP:0003363)2.38531943
38Duplication of thumb phalanx (HP:0009942)2.34570681
39Abnormality of the duodenum (HP:0002246)2.34436113
40Embryonal renal neoplasm (HP:0011794)2.34108900
41Breast hypoplasia (HP:0003187)2.33227664
42Facial cleft (HP:0002006)2.30821033
43Abnormal ciliary motility (HP:0012262)2.28507355
44Triphalangeal thumb (HP:0001199)2.28347103
45Rectovaginal fistula (HP:0000143)2.27506602
46Rectal fistula (HP:0100590)2.27506602
47Sloping forehead (HP:0000340)2.27176637
48Abnormal respiratory epithelium morphology (HP:0012253)2.25508707
49Abnormal respiratory motile cilium morphology (HP:0005938)2.25508707
50Bone marrow hypocellularity (HP:0005528)2.23177551
51Abnormal respiratory motile cilium physiology (HP:0012261)2.22622848
52Myelodysplasia (HP:0002863)2.22563032
53Gastrointestinal atresia (HP:0002589)2.20581366
54Patellar aplasia (HP:0006443)2.20109420
55Absent septum pellucidum (HP:0001331)2.18399436
56Rib fusion (HP:0000902)2.17126894
57Short thumb (HP:0009778)2.13415970
58Tubulointerstitial nephritis (HP:0001970)2.13178434
59Upper limb muscle weakness (HP:0003484)2.11797976
60Intestinal fistula (HP:0100819)2.11527202
61Medulloblastoma (HP:0002885)2.09131330
62Preaxial hand polydactyly (HP:0001177)2.08635364
63True hermaphroditism (HP:0010459)2.08361672
64Abnormality of the septum pellucidum (HP:0007375)2.06542571
65Anal stenosis (HP:0002025)2.06101512
66Microvesicular hepatic steatosis (HP:0001414)2.04851468
67Selective tooth agenesis (HP:0001592)2.04578977
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.03916411
69Hypoplasia of the fovea (HP:0007750)2.03916411
70Pancreatic fibrosis (HP:0100732)2.02807532
71Tracheoesophageal fistula (HP:0002575)2.02339950
72Adrenal hypoplasia (HP:0000835)2.01652909
73Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.97615222
74Aplasia/Hypoplasia of the patella (HP:0006498)1.95015011
75Ependymoma (HP:0002888)1.94566854
76Postaxial foot polydactyly (HP:0001830)1.94323985
77Asplenia (HP:0001746)1.92533080
78Distal lower limb muscle weakness (HP:0009053)1.89095362
79Sex reversal (HP:0012245)1.87764584
80Abnormal sex determination (HP:0012244)1.87764584
81Chronic hepatic failure (HP:0100626)1.87545022
82Esophageal atresia (HP:0002032)1.86594586
83Neoplasm of the oral cavity (HP:0100649)1.86347034
84Abnormal number of incisors (HP:0011064)1.85071550
85Congenital stationary night blindness (HP:0007642)1.84236931
86Type I transferrin isoform profile (HP:0003642)1.83692342
87Nephronophthisis (HP:0000090)1.82753629
88Type 2 muscle fiber atrophy (HP:0003554)1.82521031
89Supernumerary bones of the axial skeleton (HP:0009144)1.81267973
90Osteomalacia (HP:0002749)1.81125332
91Pancreatic cysts (HP:0001737)1.76865453
92Congenital hepatic fibrosis (HP:0002612)1.75179841
93Breast aplasia (HP:0100783)1.74560056
94Astigmatism (HP:0000483)1.71898268
95Abnormal lung lobation (HP:0002101)1.70547702
96Anal atresia (HP:0002023)1.70153839
97Male pseudohermaphroditism (HP:0000037)1.67528656
98Oligohydramnios (HP:0001562)1.66455400
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.66289567
100Maternal diabetes (HP:0009800)1.66036342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.00378609
2AKT33.88913288
3SRPK12.96544127
4ZAK2.92686853
5EPHA22.83708575
6CDK122.82881595
7STK38L2.54017576
8EIF2AK22.44951939
9TTK2.30210696
10PLK42.10317162
11BRD42.00228294
12NEK11.97870765
13YES11.97204281
14NEK21.96625751
15WEE11.92368807
16PRPF4B1.89197270
17CDC71.88368405
18MKNK21.83385252
19ATR1.71299106
20STK161.64738940
21TAOK21.61778653
22PLK11.61235014
23TXK1.57816085
24CHEK21.54089358
25CDK71.39979836
26MKNK11.34687895
27PDK21.33970851
28BUB11.32526401
29IRAK31.27967474
30PLK31.25941994
31ADRBK21.24547981
32NEK61.22055486
33TSSK61.21850087
34EIF2AK31.20779435
35CDK31.15940511
36TNIK1.14344999
37EIF2AK11.14229267
38SIK31.12187796
39PASK1.11859979
40VRK11.11207367
41TLK11.09732364
42PDK41.06300902
43PDK31.06300902
44MAP2K71.03922018
45GRK11.02629693
46ATM0.98779410
47RPS6KB20.95821704
48DYRK30.95820800
49MAP3K140.93824106
50PINK10.90794750
51SGK20.90784415
52CHEK10.87794918
53ERBB30.83703988
54MAPK130.81601350
55AURKB0.81147718
56MUSK0.79398720
57PIM10.78807406
58PNCK0.76959541
59BMPR20.75761007
60DYRK20.71743778
61CDK40.71160948
62BRAF0.70588138
63PLK20.67291907
64ERBB40.66881802
65CDK20.63098045
66STK40.61104810
67AURKA0.59924441
68INSRR0.54634971
69ACVR1B0.53480948
70CDK10.53351194
71CSNK2A10.51874972
72TNK20.51656701
73CDK80.50479326
74CSNK1D0.46661601
75CSNK2A20.45546329
76CCNB10.45433096
77AKT20.45231697
78WNK30.44512821
79MAPK70.43436579
80PRKCI0.43144536
81IRAK40.42937156
82AKT10.41777053
83RPS6KB10.41262828
84MAPK140.39964787
85BCR0.38047088
86PRKDC0.37747779
87STK240.37520719
88GSK3B0.36815285
89ICK0.36318049
90PBK0.36210976
91IKBKB0.35741636
92TEC0.35592288
93DAPK10.35372183
94STK380.35113575
95STK30.32796357
96GRK70.30217934
97SGK30.28256821
98CHUK0.26235789
99PRKCG0.25420734
100MAPK10.25212445

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.06974745
2Mismatch repair_Homo sapiens_hsa034303.83579129
3Homologous recombination_Homo sapiens_hsa034403.71891973
4DNA replication_Homo sapiens_hsa030303.57009172
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51049801
6Non-homologous end-joining_Homo sapiens_hsa034503.45980607
7One carbon pool by folate_Homo sapiens_hsa006703.13525361
8Base excision repair_Homo sapiens_hsa034102.81588378
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.54579414
10Nucleotide excision repair_Homo sapiens_hsa034202.50313520
11Basal transcription factors_Homo sapiens_hsa030222.48633868
12RNA transport_Homo sapiens_hsa030132.38809663
13RNA polymerase_Homo sapiens_hsa030202.27948404
14Spliceosome_Homo sapiens_hsa030402.11260030
15Cell cycle_Homo sapiens_hsa041102.05484128
16Pyrimidine metabolism_Homo sapiens_hsa002401.93253190
17mRNA surveillance pathway_Homo sapiens_hsa030151.88798403
18RNA degradation_Homo sapiens_hsa030181.68946125
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54486515
20p53 signaling pathway_Homo sapiens_hsa041151.54263880
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49982435
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47262675
23Purine metabolism_Homo sapiens_hsa002301.46312031
24Nicotine addiction_Homo sapiens_hsa050331.36530847
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33165357
26Proteasome_Homo sapiens_hsa030501.28919579
27Graft-versus-host disease_Homo sapiens_hsa053321.27826542
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22097042
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19622498
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10400305
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09045185
32Basal cell carcinoma_Homo sapiens_hsa052171.06132161
33Autoimmune thyroid disease_Homo sapiens_hsa053201.04489182
34Systemic lupus erythematosus_Homo sapiens_hsa053221.03077366
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01278560
36Herpes simplex infection_Homo sapiens_hsa051680.99795601
37Arachidonic acid metabolism_Homo sapiens_hsa005900.97210166
38Allograft rejection_Homo sapiens_hsa053300.92752309
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.84756329
40Epstein-Barr virus infection_Homo sapiens_hsa051690.83889406
41Hematopoietic cell lineage_Homo sapiens_hsa046400.73488259
42Type I diabetes mellitus_Homo sapiens_hsa049400.70568666
43Vitamin digestion and absorption_Homo sapiens_hsa049770.67748330
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66269102
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65487337
46Ribosome_Homo sapiens_hsa030100.65058501
47Phototransduction_Homo sapiens_hsa047440.64928630
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64840344
49Taste transduction_Homo sapiens_hsa047420.64040733
50Linoleic acid metabolism_Homo sapiens_hsa005910.63583275
51Sphingolipid metabolism_Homo sapiens_hsa006000.63507331
52Hedgehog signaling pathway_Homo sapiens_hsa043400.61120698
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60423433
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59845022
55Asthma_Homo sapiens_hsa053100.57315159
56Measles_Homo sapiens_hsa051620.56440821
57Viral carcinogenesis_Homo sapiens_hsa052030.55768016
58Inositol phosphate metabolism_Homo sapiens_hsa005620.54746163
59Hippo signaling pathway_Homo sapiens_hsa043900.53846541
60Other glycan degradation_Homo sapiens_hsa005110.53417154
61Fructose and mannose metabolism_Homo sapiens_hsa000510.52539339
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52385856
63Notch signaling pathway_Homo sapiens_hsa043300.52310002
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.51794475
65Regulation of autophagy_Homo sapiens_hsa041400.47815404
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45517169
67Influenza A_Homo sapiens_hsa051640.44812085
68HTLV-I infection_Homo sapiens_hsa051660.43973103
69Oocyte meiosis_Homo sapiens_hsa041140.42108482
70Ether lipid metabolism_Homo sapiens_hsa005650.42050107
71Legionellosis_Homo sapiens_hsa051340.41697436
72Wnt signaling pathway_Homo sapiens_hsa043100.41206813
73Primary immunodeficiency_Homo sapiens_hsa053400.40682453
74Collecting duct acid secretion_Homo sapiens_hsa049660.39442707
75Alcoholism_Homo sapiens_hsa050340.38264276
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36490617
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.35985092
78Rheumatoid arthritis_Homo sapiens_hsa053230.35662633
79Vitamin B6 metabolism_Homo sapiens_hsa007500.34590034
80Melanoma_Homo sapiens_hsa052180.34552423
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.33811405
82TGF-beta signaling pathway_Homo sapiens_hsa043500.33305305
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.31988283
84MicroRNAs in cancer_Homo sapiens_hsa052060.29908650
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29791001
86Metabolic pathways_Homo sapiens_hsa011000.27037613
87Morphine addiction_Homo sapiens_hsa050320.24853478
88Calcium signaling pathway_Homo sapiens_hsa040200.24712958
89Selenocompound metabolism_Homo sapiens_hsa004500.24628451
90Pathways in cancer_Homo sapiens_hsa052000.24338365
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22233949
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21351837
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20707331
94Retinol metabolism_Homo sapiens_hsa008300.20078688
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19414457
96Lysine degradation_Homo sapiens_hsa003100.18716764
97Arginine and proline metabolism_Homo sapiens_hsa003300.18423098
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18292508
99African trypanosomiasis_Homo sapiens_hsa051430.16029836
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15950742

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