TRIML2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)5.20640728
2regulation of posttranscriptional gene silencing (GO:0060147)5.20640728
3regulation of gene silencing by miRNA (GO:0060964)5.20640728
4DNA replication initiation (GO:0006270)4.90044277
5regulation of helicase activity (GO:0051095)4.76115507
6nuclear pore organization (GO:0006999)4.75013936
7nucleobase biosynthetic process (GO:0046112)4.56662257
8mitotic metaphase plate congression (GO:0007080)4.54591739
9protein K6-linked ubiquitination (GO:0085020)4.42384572
10nuclear pore complex assembly (GO:0051292)4.41193910
11purine nucleobase biosynthetic process (GO:0009113)4.39032058
12ribosome assembly (GO:0042255)4.33226482
13regulation of nuclear cell cycle DNA replication (GO:0033262)4.32806575
14somatic diversification of immune receptors via somatic mutation (GO:0002566)4.27755502
15somatic hypermutation of immunoglobulin genes (GO:0016446)4.27755502
16DNA replication checkpoint (GO:0000076)4.18486981
17DNA strand elongation involved in DNA replication (GO:0006271)4.13841877
18DNA replication-dependent nucleosome organization (GO:0034723)4.12056633
19DNA replication-dependent nucleosome assembly (GO:0006335)4.12056633
20protein localization to kinetochore (GO:0034501)4.04652872
21ribosome biogenesis (GO:0042254)4.03646934
22water-soluble vitamin biosynthetic process (GO:0042364)3.96254376
23DNA strand elongation (GO:0022616)3.95823310
24maturation of SSU-rRNA (GO:0030490)3.94833871
25IMP biosynthetic process (GO:0006188)3.94078923
26metaphase plate congression (GO:0051310)3.88972135
27telomere maintenance via semi-conservative replication (GO:0032201)3.85766164
28mitotic nuclear envelope disassembly (GO:0007077)3.84221069
29formation of translation preinitiation complex (GO:0001731)3.80415770
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.79985887
31chromatin remodeling at centromere (GO:0031055)3.78676827
32behavioral response to nicotine (GO:0035095)3.77287733
33regulation of telomere maintenance via telomerase (GO:0032210)3.72738271
34chaperone-mediated protein transport (GO:0072321)3.64958258
35DNA unwinding involved in DNA replication (GO:0006268)3.60999000
36determination of adult lifespan (GO:0008340)3.60536126
37kinetochore organization (GO:0051383)3.59768017
38CENP-A containing nucleosome assembly (GO:0034080)3.58662152
39pseudouridine synthesis (GO:0001522)3.56349698
40membrane disassembly (GO:0030397)3.55658223
41nuclear envelope disassembly (GO:0051081)3.55658223
42kinetochore assembly (GO:0051382)3.54211675
43pore complex assembly (GO:0046931)3.52974505
44folic acid-containing compound biosynthetic process (GO:0009396)3.52907405
45ribonucleoprotein complex biogenesis (GO:0022613)3.50564371
46histone H4-K12 acetylation (GO:0043983)3.48680193
47mitotic sister chromatid segregation (GO:0000070)3.48244862
48telomere maintenance via telomere lengthening (GO:0010833)3.47553113
49telomere maintenance via recombination (GO:0000722)3.45875069
50regulation of histone H3-K9 methylation (GO:0051570)3.45549044
51establishment of chromosome localization (GO:0051303)3.44907995
52regulation of mitotic spindle checkpoint (GO:1903504)3.43819451
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.43819451
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.39958105
55negative regulation of translation, ncRNA-mediated (GO:0040033)3.39958105
56regulation of translation, ncRNA-mediated (GO:0045974)3.39958105
57protein localization to chromosome, centromeric region (GO:0071459)3.38870704
58DNA geometric change (GO:0032392)3.37009677
59mitotic recombination (GO:0006312)3.36335243
60DNA duplex unwinding (GO:0032508)3.35843907
61IMP metabolic process (GO:0046040)3.33042051
62regulation of double-strand break repair via homologous recombination (GO:0010569)3.31133533
63lung-associated mesenchyme development (GO:0060484)3.30810729
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.30687348
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.30535994
66regulation of centrosome cycle (GO:0046605)3.30501968
67paraxial mesoderm development (GO:0048339)3.29844528
68DNA replication-independent nucleosome assembly (GO:0006336)3.29120201
69DNA replication-independent nucleosome organization (GO:0034724)3.29120201
70regulation of spindle organization (GO:0090224)3.27653165
71regulation of centriole replication (GO:0046599)3.26793386
72intra-S DNA damage checkpoint (GO:0031573)3.26320521
73negative regulation of histone methylation (GO:0031061)3.25876658
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24738012
75mitochondrial respiratory chain complex I assembly (GO:0032981)3.24738012
76NADH dehydrogenase complex assembly (GO:0010257)3.24738012
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23905217
78mismatch repair (GO:0006298)3.22515289
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19829597
80termination of RNA polymerase III transcription (GO:0006386)3.19599818
81transcription elongation from RNA polymerase III promoter (GO:0006385)3.19599818
82ribosomal large subunit biogenesis (GO:0042273)3.19185690
83rRNA processing (GO:0006364)3.16998339
84attachment of spindle microtubules to kinetochore (GO:0008608)3.16241597
85negative regulation of chromosome segregation (GO:0051985)3.16098552
86histone exchange (GO:0043486)3.15514476
87rRNA modification (GO:0000154)3.14406826
88DNA deamination (GO:0045006)3.14069295
89regulation of mitotic spindle organization (GO:0060236)3.13306512
90protein complex biogenesis (GO:0070271)3.12821283
91mitochondrial respiratory chain complex assembly (GO:0033108)3.12188262
92DNA double-strand break processing (GO:0000729)3.10880673
93regulation of gene silencing (GO:0060968)3.10642346
94positive regulation of chromosome segregation (GO:0051984)3.09418493
95rRNA metabolic process (GO:0016072)3.07688655
96spindle checkpoint (GO:0031577)3.07480568
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.07006502
98meiotic chromosome segregation (GO:0045132)3.06768346
99replication fork processing (GO:0031297)3.06130585
100negative regulation of mitotic sister chromatid separation (GO:2000816)3.05484498
101negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05484498
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05484498
103negative regulation of sister chromatid segregation (GO:0033046)3.05484498
104mitotic spindle checkpoint (GO:0071174)3.00906217
105nucleotide-excision repair, DNA gap filling (GO:0006297)3.00829205
106transcription-coupled nucleotide-excision repair (GO:0006283)3.00389543
107histone arginine methylation (GO:0034969)2.98538044
108spindle assembly checkpoint (GO:0071173)2.98367493
109sister chromatid segregation (GO:0000819)2.97644664
110spliceosomal snRNP assembly (GO:0000387)2.97321799
111negative regulation of telomerase activity (GO:0051974)2.96858908
112positive regulation of SMAD protein import into nucleus (GO:0060391)2.96457103
113folic acid metabolic process (GO:0046655)2.96337275
114telomere maintenance (GO:0000723)2.95818564
115sulfation (GO:0051923)2.95696773
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95377652
117mitotic spindle assembly checkpoint (GO:0007094)2.95094029
118telomere organization (GO:0032200)2.95052376
119regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94762121
120kidney morphogenesis (GO:0060993)2.94456321
121negative regulation of telomere maintenance (GO:0032205)2.94079051
122transcription from RNA polymerase I promoter (GO:0006360)2.94070403
123maturation of 5.8S rRNA (GO:0000460)2.93407521
124ribosomal small subunit assembly (GO:0000028)2.93348019
125regulation of chromosome segregation (GO:0051983)2.92859940
126negative regulation of DNA-dependent DNA replication (GO:2000104)2.92243066
127anterior/posterior axis specification, embryo (GO:0008595)2.89597222
128regulation of mesoderm development (GO:2000380)2.88598074
129RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87688799
130cell fate commitment involved in formation of primary germ layer (GO:0060795)2.87666909
131ncRNA catabolic process (GO:0034661)2.85363870
132rRNA methylation (GO:0031167)2.84834139
133respiratory chain complex IV assembly (GO:0008535)2.84765817
134regulation of hippo signaling (GO:0035330)2.84015850
135protein polyglutamylation (GO:0018095)2.83094420
136DNA damage response, detection of DNA damage (GO:0042769)2.77195247
137single strand break repair (GO:0000012)2.75493908
138protein-cofactor linkage (GO:0018065)2.73748123
139regulation of meiosis I (GO:0060631)2.72186080
140energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71849473
141ATP synthesis coupled proton transport (GO:0015986)2.71849473
142recombinational repair (GO:0000725)2.71679477
143otic vesicle formation (GO:0030916)2.71661448
144double-strand break repair via homologous recombination (GO:0000724)2.70877747
145nodal signaling pathway (GO:0038092)2.67963459
146mitochondrial RNA metabolic process (GO:0000959)2.66407335
147transcription elongation from RNA polymerase I promoter (GO:0006362)2.61033476
148piRNA metabolic process (GO:0034587)2.60224327
149somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.59645565
150somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.59645565
151isotype switching (GO:0045190)2.59645565
152tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58186672
153RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58186672
154negative regulation of gene silencing (GO:0060969)2.58084590
155male meiosis I (GO:0007141)2.57921761
156negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57363779
157cytochrome complex assembly (GO:0017004)2.56867217
158somatic diversification of immunoglobulins (GO:0016445)2.53944073
159negative regulation of androgen receptor signaling pathway (GO:0060766)2.52929983
160regulation of DNA methylation (GO:0044030)2.51572941
161regulation of cell fate commitment (GO:0010453)2.51338800
162cell migration involved in gastrulation (GO:0042074)2.49830329
163L-fucose catabolic process (GO:0042355)2.49334000
164fucose catabolic process (GO:0019317)2.49334000
165L-fucose metabolic process (GO:0042354)2.49334000
166regulation of mitochondrial translation (GO:0070129)2.45799641
167proteasome assembly (GO:0043248)2.45537357
168somatic recombination of immunoglobulin gene segments (GO:0016447)2.43250463
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43183843
170synapsis (GO:0007129)2.41850152
171centriole replication (GO:0007099)2.40797479
172regulation of DNA endoreduplication (GO:0032875)2.40186792
173transcription from mitochondrial promoter (GO:0006390)2.39869596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55350258
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.07995506
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.67117204
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41141316
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.30856175
6ZNF274_21170338_ChIP-Seq_K562_Hela3.28291198
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.25391960
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.23363594
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.23363594
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.23363594
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.96769876
12VDR_22108803_ChIP-Seq_LS180_Human2.85185100
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83795761
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76064414
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.73270675
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.66150706
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.59295607
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56886479
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56247157
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55474063
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40745416
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38049800
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37927202
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.36077258
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35733141
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.34465681
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.33736533
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27304115
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26106188
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.25465297
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.22554285
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.21640689
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.16752969
34POU5F1_16153702_ChIP-ChIP_HESCs_Human2.16056202
35TCF3_18692474_ChIP-Seq_MEFs_Mouse2.10293976
36EWS_26573619_Chip-Seq_HEK293_Human2.10050703
37STAT3_1855785_ChIP-Seq_MESCs_Mouse2.08726961
38NOTCH1_21737748_ChIP-Seq_TLL_Human2.04499658
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04477649
40GABP_17652178_ChIP-ChIP_JURKAT_Human2.04020264
41FUS_26573619_Chip-Seq_HEK293_Human2.02948742
42SOX2_18555785_ChIP-Seq_MESCs_Mouse2.02002789
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99153827
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98532278
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97303374
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97230390
47TCF3_18692474_ChIP-Seq_MESCs_Mouse1.90467945
48MYC_18940864_ChIP-ChIP_HL60_Human1.88092367
49SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.87816489
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.86993295
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85523252
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85427826
53P300_19829295_ChIP-Seq_ESCs_Human1.82677022
54XRN2_22483619_ChIP-Seq_HELA_Human1.82464861
55NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.79468396
56GBX2_23144817_ChIP-Seq_PC3_Human1.79366138
57NANOG_16153702_ChIP-ChIP_HESCs_Human1.79021990
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.76200199
59* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.76035796
60VDR_23849224_ChIP-Seq_CD4+_Human1.73832596
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71146488
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.70808410
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70042688
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.68207174
65IGF1R_20145208_ChIP-Seq_DFB_Human1.64907240
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.64262844
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60852292
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56803272
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55799992
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55043986
71TAF15_26573619_Chip-Seq_HEK293_Human1.54983691
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54201284
73AR_21909140_ChIP-Seq_LNCAP_Human1.53003584
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52704226
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51140687
76FOXP3_21729870_ChIP-Seq_TREG_Human1.50633805
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49755558
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47842710
79DCP1A_22483619_ChIP-Seq_HELA_Human1.47462102
80TTF2_22483619_ChIP-Seq_HELA_Human1.46249619
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44999433
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44789881
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42558927
84SOX2_18692474_ChIP-Seq_MEFs_Mouse1.41835767
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40976728
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39357340
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39288689
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38426719
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36768987
90EZH2_22144423_ChIP-Seq_EOC_Human1.33077713
91SOX2_18692474_ChIP-Seq_MESCs_Mouse1.33016574
92GABP_19822575_ChIP-Seq_HepG2_Human1.32463243
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32234939
94NANOG_18692474_ChIP-Seq_MEFs_Mouse1.30955698
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.30457112
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28930407
97POU5F1_16518401_ChIP-PET_MESCs_Mouse1.26014861
98ELK1_19687146_ChIP-ChIP_HELA_Human1.25829483
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25196361
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.24228512
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.23564421
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22220625
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21143338
104NANOG_18692474_ChIP-Seq_MESCs_Mouse1.20533473
105ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19770113
106OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19263633
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19094215
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19044639
109NANOG_21062744_ChIP-ChIP_HESCs_Human1.16764266
110POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.16423801
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15078157
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14569821
113ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14310591
114ER_23166858_ChIP-Seq_MCF-7_Human1.13447740
115LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13210202
116KAP1_27257070_Chip-Seq_ESCs_Mouse1.11405534
117ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10956829
118FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09771198
119FOXA1_25329375_ChIP-Seq_VCAP_Human1.09771198
120KDM5A_27292631_Chip-Seq_BREAST_Human1.09751284
121BCAT_22108803_ChIP-Seq_LS180_Human1.07689535
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05933947
123TP53_22573176_ChIP-Seq_HFKS_Human1.05247428
124NANOG_19829295_ChIP-Seq_ESCs_Human1.04301153
125SOX2_19829295_ChIP-Seq_ESCs_Human1.04301153
126CIITA_25753668_ChIP-Seq_RAJI_Human1.03905785
127SRF_21415370_ChIP-Seq_HL-1_Mouse1.03086728
128TFEB_21752829_ChIP-Seq_HELA_Human1.02680689
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01029684
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01029684
131TCF4_22108803_ChIP-Seq_LS180_Human0.98734071
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98244326
133TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97537248
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96252233
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95032693
136CBP_20019798_ChIP-Seq_JUKART_Human0.95032693
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93724898
138AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93231979
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92529135
140HOXB7_26014856_ChIP-Seq_BT474_Human0.92500808
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92498859
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92396799
143SMAD3_21741376_ChIP-Seq_EPCs_Human0.92167172
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92127806
145SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91890989
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91703771
147* TCF4_23295773_ChIP-Seq_U87_Human0.91556993
148HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91309670
149RNF2_27304074_Chip-Seq_NSC_Mouse0.91235143
150CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91153197
151* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90287001
152RUNX2_22187159_ChIP-Seq_PCA_Human0.90120796
153NANOG_16518401_ChIP-PET_MESCs_Mouse0.89832926
154PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89042557
155POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88816178
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88700385
157IRF1_19129219_ChIP-ChIP_H3396_Human0.86838204
158TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85812770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.29408537
2MP0008057_abnormal_DNA_replication4.70449207
3MP0010094_abnormal_chromosome_stability4.65860072
4MP0003111_abnormal_nucleus_morphology4.65709564
5MP0004957_abnormal_blastocyst_morpholog4.31156831
6MP0008058_abnormal_DNA_repair3.87759773
7MP0003077_abnormal_cell_cycle3.82782810
8MP0002254_reproductive_system_inflammat2.94213850
9MP0003806_abnormal_nucleotide_metabolis2.77488730
10MP0003136_yellow_coat_color2.69641641
11MP0004133_heterotaxia2.67682096
12MP0008932_abnormal_embryonic_tissue2.54604670
13MP0010352_gastrointestinal_tract_polyps2.43551445
14MP0002653_abnormal_ependyma_morphology2.39856708
15MP0006292_abnormal_olfactory_placode2.33396282
16MP0008007_abnormal_cellular_replicative2.31763491
17MP0003941_abnormal_skin_development2.30983909
18MP0003786_premature_aging2.29963459
19MP0000350_abnormal_cell_proliferation2.23524258
20MP0001730_embryonic_growth_arrest2.20527392
21MP0003718_maternal_effect2.18161095
22MP0003646_muscle_fatigue2.06780616
23MP0003123_paternal_imprinting2.02884508
24MP0001485_abnormal_pinna_reflex1.92301458
25MP0010307_abnormal_tumor_latency1.90625891
26MP0001672_abnormal_embryogenesis/_devel1.89512500
27MP0005380_embryogenesis_phenotype1.89512500
28MP0008877_abnormal_DNA_methylation1.87680640
29MP0002837_dystrophic_cardiac_calcinosis1.84152497
30MP0002085_abnormal_embryonic_tissue1.79041936
31MP0002084_abnormal_developmental_patter1.75470912
32MP0001293_anophthalmia1.73298805
33MP0005551_abnormal_eye_electrophysiolog1.71554858
34MP0000049_abnormal_middle_ear1.65879868
35MP0001697_abnormal_embryo_size1.64759602
36MP0003890_abnormal_embryonic-extraembry1.64032648
37MP0003283_abnormal_digestive_organ1.63618962
38MP0002086_abnormal_extraembryonic_tissu1.62533700
39MP0002138_abnormal_hepatobiliary_system1.60192226
40MP0003195_calcinosis1.59246803
41MP0000631_abnormal_neuroendocrine_gland1.58652090
42MP0004197_abnormal_fetal_growth/weight/1.55552860
43MP0003984_embryonic_growth_retardation1.54452115
44MP0008872_abnormal_physiological_respon1.51573076
45MP0003119_abnormal_digestive_system1.51067713
46MP0002102_abnormal_ear_morphology1.50843189
47MP0002088_abnormal_embryonic_growth/wei1.50730803
48MP0002080_prenatal_lethality1.48537360
49MP0002736_abnormal_nociception_after1.47284629
50MP0001968_abnormal_touch/_nociception1.46888745
51MP0002938_white_spotting1.45141117
52MP0002210_abnormal_sex_determination1.44622692
53MP0005646_abnormal_pituitary_gland1.40019521
54MP0003121_genomic_imprinting1.39760452
55MP0000490_abnormal_crypts_of1.34839547
56MP0006035_abnormal_mitochondrial_morpho1.32757947
57MP0000313_abnormal_cell_death1.28793192
58MP0001145_abnormal_male_reproductive1.27798821
59MP0003011_delayed_dark_adaptation1.26931365
60MP0003567_abnormal_fetal_cardiomyocyte1.18365493
61MP0004264_abnormal_extraembryonic_tissu1.16991677
62MP0009379_abnormal_foot_pigmentation1.13534410
63MP0004885_abnormal_endolymph1.13315221
64MP0003186_abnormal_redox_activity1.12545670
65MP0005076_abnormal_cell_differentiation1.11156452
66MP0003938_abnormal_ear_development1.10528276
67MP0003315_abnormal_perineum_morphology1.10335584
68MP0002019_abnormal_tumor_incidence1.09227987
69MP0005253_abnormal_eye_physiology1.08494444
70MP0005379_endocrine/exocrine_gland_phen1.07878199
71MP0009046_muscle_twitch1.07554003
72MP0001986_abnormal_taste_sensitivity1.06370430
73MP0002396_abnormal_hematopoietic_system1.05745061
74MP0009745_abnormal_behavioral_response1.05076872
75MP0001929_abnormal_gametogenesis1.04200560
76MP0005266_abnormal_metabolism1.03431035
77MP0000653_abnormal_sex_gland1.03345232
78MP0002272_abnormal_nervous_system1.02716566
79MP0002638_abnormal_pupillary_reflex1.02531255
80MP0000516_abnormal_urinary_system1.02425795
81MP0005367_renal/urinary_system_phenotyp1.02425795
82MP0005410_abnormal_fertilization1.00748928
83MP0000371_diluted_coat_color1.00280836
84MP0002751_abnormal_autonomic_nervous0.99930744
85MP0005084_abnormal_gallbladder_morpholo0.98332545
86MP0001286_abnormal_eye_development0.98213393
87MP0003787_abnormal_imprinting0.97814138
88MP0000537_abnormal_urethra_morphology0.97572511
89MP0001849_ear_inflammation0.96938658
90MP0002277_abnormal_respiratory_mucosa0.96757762
91MP0003566_abnormal_cell_adhesion0.95180800
92MP0002160_abnormal_reproductive_system0.94763385
93MP0004145_abnormal_muscle_electrophysio0.93815217
94MP0000383_abnormal_hair_follicle0.93688578
95MP0002163_abnormal_gland_morphology0.92771032
96MP0004742_abnormal_vestibular_system0.91894183
97MP0000647_abnormal_sebaceous_gland0.91614251
98MP0001486_abnormal_startle_reflex0.91234522
99MP0002111_abnormal_tail_morphology0.87949440
100MP0004142_abnormal_muscle_tone0.87319551
101MP0005389_reproductive_system_phenotype0.87000695
102MP0004215_abnormal_myocardial_fiber0.86862570
103MP0010030_abnormal_orbit_morphology0.86813189
104MP0005195_abnormal_posterior_eye0.85643969
105MP0002075_abnormal_coat/hair_pigmentati0.83577341
106MP0005384_cellular_phenotype0.82790353
107MP0002735_abnormal_chemical_nociception0.82257898
108MP0003936_abnormal_reproductive_system0.82214014
109MP0003937_abnormal_limbs/digits/tail_de0.82188999
110MP0001119_abnormal_female_reproductive0.81444295
111MP0005645_abnormal_hypothalamus_physiol0.80771087
112MP0005395_other_phenotype0.80132398
113MP0001529_abnormal_vocalization0.79225171
114MP0005621_abnormal_cell_physiology0.79067778
115MP0008789_abnormal_olfactory_epithelium0.77722441
116MP0004019_abnormal_vitamin_homeostasis0.77638585
117MP0006276_abnormal_autonomic_nervous0.75598140
118MP0009250_abnormal_appendicular_skeleto0.75541595
119MP0000358_abnormal_cell_content/0.74047080
120MP0003950_abnormal_plasma_membrane0.73573949
121MP0001186_pigmentation_phenotype0.73514601
122MP0005075_abnormal_melanosome_morpholog0.73312701
123MP0002733_abnormal_thermal_nociception0.72213585
124MP0002752_abnormal_somatic_nervous0.71581216
125MP0001188_hyperpigmentation0.71245315
126MP0009703_decreased_birth_body0.69981381
127MP0000579_abnormal_nail_morphology0.69769572
128MP0003861_abnormal_nervous_system0.69479635
129MP0002127_abnormal_cardiovascular_syste0.68873138
130MP0002092_abnormal_eye_morphology0.68783056
131MP0005083_abnormal_biliary_tract0.68131171
132MP0002697_abnormal_eye_size0.67819902
133MP0002734_abnormal_mechanical_nocicepti0.67656340
134MP0008770_decreased_survivor_rate0.67646406
135MP0000858_altered_metastatic_potential0.67302640
136MP0003698_abnormal_male_reproductive0.67185056
137MP0001919_abnormal_reproductive_system0.65652608
138MP0005377_hearing/vestibular/ear_phenot0.65036916
139MP0003878_abnormal_ear_physiology0.65036916
140MP0005501_abnormal_skin_physiology0.64870432
141MP0005023_abnormal_wound_healing0.64244719
142MP0000432_abnormal_head_morphology0.61910165
143MP0002249_abnormal_larynx_morphology0.61333437
144MP0002132_abnormal_respiratory_system0.59134821
145MP0006072_abnormal_retinal_apoptosis0.58762977
146MP0003755_abnormal_palate_morphology0.58158176
147MP0002161_abnormal_fertility/fecundity0.56014860
148MP0000627_abnormal_mammary_gland0.55619747
149MP0002332_abnormal_exercise_endurance0.55563763
150MP0003699_abnormal_female_reproductive0.54360736
151MP0005670_abnormal_white_adipose0.54178272
152MP0008995_early_reproductive_senescence0.51541409
153MP0000477_abnormal_intestine_morphology0.51073820

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.24792048
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.08055882
3Chromsome breakage (HP:0040012)4.97249027
4Breast hypoplasia (HP:0003187)4.86209229
5Ependymoma (HP:0002888)4.76034211
6Abnormality of the labia minora (HP:0012880)4.70611910
7Absent radius (HP:0003974)3.98609743
8Pendular nystagmus (HP:0012043)3.88557582
9Medulloblastoma (HP:0002885)3.83384288
10Agnosia (HP:0010524)3.75840471
11Absent forearm bone (HP:0003953)3.73680607
12Aplasia involving forearm bones (HP:0009822)3.73680607
13Supernumerary spleens (HP:0009799)3.55603976
14Carpal bone hypoplasia (HP:0001498)3.51742143
15Meckel diverticulum (HP:0002245)3.41972013
16Abnormality of chromosome stability (HP:0003220)3.38516300
17Duplicated collecting system (HP:0000081)3.35423121
18Absent thumb (HP:0009777)3.34471104
19Reticulocytopenia (HP:0001896)3.34421870
20Patellar aplasia (HP:0006443)3.33683755
21Impulsivity (HP:0100710)3.32092992
22Abnormality of the ileum (HP:0001549)3.31393675
23Abnormality of the astrocytes (HP:0100707)3.29400454
24Astrocytoma (HP:0009592)3.29400454
25Neoplasm of the oral cavity (HP:0100649)3.29003100
26Aplasia/Hypoplasia of the uvula (HP:0010293)3.28037855
27Rhabdomyosarcoma (HP:0002859)3.26836224
28Abnormality of the preputium (HP:0100587)3.24520300
29Glioma (HP:0009733)3.11400175
30Aplasia/Hypoplasia of the patella (HP:0006498)3.10034075
31Colon cancer (HP:0003003)3.07739314
32Bilateral microphthalmos (HP:0007633)3.04262627
33Abnormality of the renal collecting system (HP:0004742)3.00102726
34Aplasia/hypoplasia of the humerus (HP:0006507)2.98663494
35Pancreatic cysts (HP:0001737)2.98454873
36Selective tooth agenesis (HP:0001592)2.89125041
37Pancreatic fibrosis (HP:0100732)2.86072758
38Rib fusion (HP:0000902)2.85508849
39Rectal fistula (HP:0100590)2.76681221
40Rectovaginal fistula (HP:0000143)2.76681221
41Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.76526432
42Methylmalonic acidemia (HP:0002912)2.75482711
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.75226973
44Oral leukoplakia (HP:0002745)2.72148456
45Short humerus (HP:0005792)2.65789686
46Abolished electroretinogram (ERG) (HP:0000550)2.65375218
47Genetic anticipation (HP:0003743)2.63741398
48Abdominal situs inversus (HP:0003363)2.62345986
49Abnormality of abdominal situs (HP:0011620)2.62345986
50Degeneration of anterior horn cells (HP:0002398)2.61619763
51Abnormality of the anterior horn cell (HP:0006802)2.61619763
52Small intestinal stenosis (HP:0012848)2.59670597
53Duodenal stenosis (HP:0100867)2.59670597
54Molar tooth sign on MRI (HP:0002419)2.59036208
55Abnormality of midbrain morphology (HP:0002418)2.59036208
56Rough bone trabeculation (HP:0100670)2.58307208
57Shawl scrotum (HP:0000049)2.57949346
58Stenosis of the external auditory canal (HP:0000402)2.56390652
59True hermaphroditism (HP:0010459)2.55432879
60Ectopic kidney (HP:0000086)2.52042626
61Abnormality of pyrimidine metabolism (HP:0004353)2.49550408
62Cerebral hypomyelination (HP:0006808)2.47807663
63Horseshoe kidney (HP:0000085)2.47785198
64Bone marrow hypocellularity (HP:0005528)2.47483857
65Neoplasm of striated muscle (HP:0009728)2.46433693
66Short hallux (HP:0010109)2.43753452
67Abnormal number of erythroid precursors (HP:0012131)2.41905051
68Congenital stationary night blindness (HP:0007642)2.41430006
69Nephronophthisis (HP:0000090)2.41031992
70Myelodysplasia (HP:0002863)2.40641092
71Missing ribs (HP:0000921)2.38074579
72Abnormality of alanine metabolism (HP:0010916)2.36248878
73Hyperalaninemia (HP:0003348)2.36248878
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36248878
75Esophageal atresia (HP:0002032)2.35794058
76Intestinal fistula (HP:0100819)2.35699578
77Aplasia/Hypoplasia of the hallux (HP:0008362)2.35400553
78Acute necrotizing encephalopathy (HP:0006965)2.35009886
79Sloping forehead (HP:0000340)2.33467863
80Tracheoesophageal fistula (HP:0002575)2.30938133
81Methylmalonic aciduria (HP:0012120)2.30483030
82Optic nerve hypoplasia (HP:0000609)2.29369933
83Hyperglycinemia (HP:0002154)2.28707496
84Abnormal number of incisors (HP:0011064)2.28032250
85Abnormality of cells of the erythroid lineage (HP:0012130)2.28024164
86Abnormality of the salivary glands (HP:0010286)2.27867444
87Abnormality of the duodenum (HP:0002246)2.27787591
88Asplenia (HP:0001746)2.24713313
89Anal stenosis (HP:0002025)2.21725491
90Biliary tract neoplasm (HP:0100574)2.21717268
91Premature ovarian failure (HP:0008209)2.21606787
92Short thumb (HP:0009778)2.21508382
93Triphalangeal thumb (HP:0001199)2.20708125
94Neoplasm of the pancreas (HP:0002894)2.19400776
95Premature graying of hair (HP:0002216)2.18594028
96Breast aplasia (HP:0100783)2.18476384
97Vaginal fistula (HP:0004320)2.18054220
98Spinal muscular atrophy (HP:0007269)2.16167176
99Supernumerary bones of the axial skeleton (HP:0009144)2.16002900
100Gaze-evoked nystagmus (HP:0000640)2.15332917
101Amaurosis fugax (HP:0100576)2.14449800
102Mitochondrial inheritance (HP:0001427)2.12538546
103Septo-optic dysplasia (HP:0100842)2.12478006
104Increased CSF lactate (HP:0002490)2.12207278
105Abnormality of serum amino acid levels (HP:0003112)2.10917195
106Increased hepatocellular lipid droplets (HP:0006565)2.08413028
107Abnormality of DNA repair (HP:0003254)2.07457325
108Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05079949
109Acute encephalopathy (HP:0006846)2.04992972
110Gastrointestinal atresia (HP:0002589)2.04180265
111Chronic bronchitis (HP:0004469)2.03820523
112Abnormal rod and cone electroretinograms (HP:0008323)2.03554443
113Aplasia/Hypoplasia of the sternum (HP:0006714)2.03426216
114Abnormality of the carotid arteries (HP:0005344)2.02201133
115Hypoplasia of the pons (HP:0012110)2.01099534
116Abnormality of the pons (HP:0007361)2.00676656
117Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00300481
118Aplasia/Hypoplasia of the spleen (HP:0010451)2.00269783
119Basal cell carcinoma (HP:0002671)1.99414424
120Progressive cerebellar ataxia (HP:0002073)1.99270487
121Congenital, generalized hypertrichosis (HP:0004540)1.99191383
122Clubbing of toes (HP:0100760)1.98942671
123Abnormal sex determination (HP:0012244)1.96872566
124Sex reversal (HP:0012245)1.96872566
125Progressive macrocephaly (HP:0004481)1.96418580
126Supernumerary ribs (HP:0005815)1.96379906
127Abnormality of homocysteine metabolism (HP:0010919)1.96111578
128Homocystinuria (HP:0002156)1.96111578
129Aplasia/Hypoplasia of the breasts (HP:0010311)1.95472598
130Attenuation of retinal blood vessels (HP:0007843)1.95203965
131Abnormality of the renal medulla (HP:0100957)1.94221286
132Ureteral duplication (HP:0000073)1.93268669
133Lipid accumulation in hepatocytes (HP:0006561)1.92733876
134Abnormal trabecular bone morphology (HP:0100671)1.92611434
135Abnormality of the nasal septum (HP:0000419)1.91752151
136Breech presentation (HP:0001623)1.91654316
137Chronic hepatic failure (HP:0100626)1.91363217
138Anencephaly (HP:0002323)1.91211047
139Abnormal mitochondria in muscle tissue (HP:0008316)1.91145997
140Aplasia/hypoplasia of the uterus (HP:0008684)1.91015834
141Abnormality of serine family amino acid metabolism (HP:0010894)1.90831958
142Abnormality of glycine metabolism (HP:0010895)1.90831958
143Absent septum pellucidum (HP:0001331)1.90491048
144Hypoplasia of the uterus (HP:0000013)1.89925107
145Nephroblastoma (Wilms tumor) (HP:0002667)1.89284578
146Keratoconus (HP:0000563)1.87830898
147Increased corneal curvature (HP:0100692)1.87830898
148Hyperglycinuria (HP:0003108)1.86865152
149Maternal diabetes (HP:0009800)1.86570413
150Duplication of thumb phalanx (HP:0009942)1.86195468
151Sclerocornea (HP:0000647)1.86089288
152Abnormality of cochlea (HP:0000375)1.85737107
153Hypoplasia of the radius (HP:0002984)1.85239638
154Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.85031777
155Partial agenesis of the corpus callosum (HP:0001338)1.84194492
156Fused cervical vertebrae (HP:0002949)1.83085666
157Small hand (HP:0200055)1.82886534
158Chorioretinal atrophy (HP:0000533)1.82857402
159Trismus (HP:0000211)1.81258952
160Broad-based gait (HP:0002136)1.81153874
161Delayed puberty (HP:0000823)1.80530046
162Cafe-au-lait spot (HP:0000957)1.80110282
163Abnormality of the septum pellucidum (HP:0007375)1.79108764
164Decreased central vision (HP:0007663)1.78364550
165Abnormality of the middle phalanges of the toes (HP:0010183)1.78205921
166Abnormal lung lobation (HP:0002101)1.74684821
167Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74258130
168Hypoplasia of the fovea (HP:0007750)1.74146803
169Aplasia/Hypoplasia of the fovea (HP:0008060)1.74146803
170Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.70259657
171Hypomagnesemia (HP:0002917)1.70073404
172Inability to walk (HP:0002540)1.69854434
173Hepatocellular necrosis (HP:0001404)1.69753613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.38824706
2EPHA24.12497431
3BUB13.87989480
4TTK3.34613625
5CDC73.27268095
6AKT33.22920735
7CDK123.00576960
8FRK3.00260694
9VRK22.84287731
10SRPK12.75238137
11NEK12.69904854
12NEK22.41660402
13PLK42.39707721
14TNIK2.35156622
15NUAK12.31813138
16BMPR1B2.31224298
17GRK12.25703703
18PLK12.25644087
19RPS6KB22.14961721
20TSSK62.13314030
21EIF2AK12.00911955
22ZAK1.99835825
23CDK71.95421765
24PNCK1.85515476
25CHEK21.84091325
26TAF11.83605114
27PLK31.83312531
28ATR1.79511373
29OXSR11.79326230
30EIF2AK31.68102296
31ACVR1B1.67178807
32VRK11.52994396
33MAP4K21.52592497
34TLK11.50845677
35NME21.50145073
36AURKB1.49595717
37WNK41.49375493
38BRD41.47325022
39INSRR1.46143843
40STK161.45680625
41PASK1.45414086
42CDK191.44812216
43BRSK21.43531962
44DYRK31.42655905
45AURKA1.40146509
46MKNK21.39470292
47CHEK11.34361630
48STK38L1.32998183
49NME11.28308432
50ALK1.24481199
51CDK41.20232816
52CASK1.20162029
53MKNK11.19889574
54MAPKAPK31.17106270
55STK391.15984081
56TIE11.14680291
57ATM1.07030259
58PRKCI1.06794081
59MAP3K81.04328426
60PDK21.00481076
61LATS11.00183518
62CDK20.98424154
63STK40.97439093
64PIM10.94444911
65EIF2AK20.91434786
66BRAF0.90777043
67TESK20.89152688
68PLK20.88501592
69DYRK20.85802425
70MET0.84415114
71PRKCG0.81939854
72TRIM280.80613591
73PDK40.79505206
74PDK30.79505206
75CAMK1D0.77570604
76PAK40.76737081
77MAP3K90.76661135
78CSNK2A20.76420529
79CSNK1G10.74691740
80MST40.74389250
81FLT30.72289014
82CDK10.71529315
83PBK0.70629592
84BRSK10.69684090
85PRKCE0.68388643
86YES10.67902148
87CSNK2A10.66798544
88CSNK1G20.65665318
89PINK10.62445821
90STK100.60215827
91CAMK1G0.59578553
92CDK60.58765500
93LATS20.58645329
94MAP3K40.58433985
95CSNK1E0.58397476
96RPS6KA40.57846998
97FGFR20.56838578
98CSNK1D0.54056892
99MELK0.53766009
100RPS6KA50.52915742
101CSNK1A10.49401786
102PAK10.48766620
103FGFR10.47913398
104TAOK20.47510536
105AKT20.46869007
106MTOR0.45828856
107PRKDC0.43189322
108DAPK20.42792339
109NLK0.42773963
110TEC0.42182303
111WNK30.41681626
112ADRBK10.38781221
113CAMK2A0.37649195
114MAPK130.37423446
115CSNK1G30.36427841
116TGFBR10.35985119
117MAPK140.35634393
118BCR0.35502923
119CDK30.35228500
120NEK60.33422183
121STK30.33365189
122CAMK10.32541104
123PAK30.31859600
124ICK0.31515006
125GSK3B0.30966175
126PHKG10.30888320
127PHKG20.30888320
128AKT10.30350348
129MAPK10.30187158
130BCKDK0.28682539
131MUSK0.28650404
132ERBB40.27778080
133PRKACA0.27389063
134CCNB10.27317082
135DAPK10.27196670
136SCYL20.22791013
137MARK30.22119446
138IRAK30.21635067
139MATK0.21466540
140RPS6KB10.19153460
141MAPK100.18960928
142IKBKB0.13032044
143ADRBK20.10606895
144CHUK0.10343586

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.70739198
2DNA replication_Homo sapiens_hsa030304.62414239
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.41400610
4RNA polymerase_Homo sapiens_hsa030203.45400324
5RNA transport_Homo sapiens_hsa030133.37639740
6Homologous recombination_Homo sapiens_hsa034403.21467637
7Spliceosome_Homo sapiens_hsa030403.20496919
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.11259922
9One carbon pool by folate_Homo sapiens_hsa006703.02880472
10Nucleotide excision repair_Homo sapiens_hsa034202.92547278
11Fanconi anemia pathway_Homo sapiens_hsa034602.90081833
12Base excision repair_Homo sapiens_hsa034102.85527679
13Ribosome_Homo sapiens_hsa030102.72846356
14Proteasome_Homo sapiens_hsa030502.70376722
15Cell cycle_Homo sapiens_hsa041102.54469509
16Non-homologous end-joining_Homo sapiens_hsa034502.42676822
17Pyrimidine metabolism_Homo sapiens_hsa002402.38982588
18Oxidative phosphorylation_Homo sapiens_hsa001902.37770588
19Basal transcription factors_Homo sapiens_hsa030222.23889517
20Parkinsons disease_Homo sapiens_hsa050122.03664143
21mRNA surveillance pathway_Homo sapiens_hsa030151.97702252
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.93571349
23RNA degradation_Homo sapiens_hsa030181.93569754
24Phototransduction_Homo sapiens_hsa047441.72943515
25Nicotine addiction_Homo sapiens_hsa050331.72461982
26p53 signaling pathway_Homo sapiens_hsa041151.63125820
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35417392
28Purine metabolism_Homo sapiens_hsa002301.34261009
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33373849
30Cardiac muscle contraction_Homo sapiens_hsa042601.29682626
31Alzheimers disease_Homo sapiens_hsa050101.29581222
32Nitrogen metabolism_Homo sapiens_hsa009101.28365580
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27766299
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26762405
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25192651
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22160414
37Caffeine metabolism_Homo sapiens_hsa002321.22105894
38Protein export_Homo sapiens_hsa030601.21918019
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16679760
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15379990
41Taste transduction_Homo sapiens_hsa047421.09662748
42Epstein-Barr virus infection_Homo sapiens_hsa051691.06605496
43Ether lipid metabolism_Homo sapiens_hsa005651.05440621
44Propanoate metabolism_Homo sapiens_hsa006401.04754642
45Systemic lupus erythematosus_Homo sapiens_hsa053221.04551409
46Folate biosynthesis_Homo sapiens_hsa007901.03751994
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.01717434
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00883872
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00744116
50Tryptophan metabolism_Homo sapiens_hsa003800.98623459
51Vitamin B6 metabolism_Homo sapiens_hsa007500.97886190
52Retinol metabolism_Homo sapiens_hsa008300.94308118
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91859622
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.87853935
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86882460
56Olfactory transduction_Homo sapiens_hsa047400.86806067
57Oocyte meiosis_Homo sapiens_hsa041140.86363618
58Biosynthesis of amino acids_Homo sapiens_hsa012300.86111630
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.86032002
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85405679
61Chemical carcinogenesis_Homo sapiens_hsa052040.84002025
62Pyruvate metabolism_Homo sapiens_hsa006200.81976776
63Fructose and mannose metabolism_Homo sapiens_hsa000510.81165496
64Selenocompound metabolism_Homo sapiens_hsa004500.80020965
65Viral carcinogenesis_Homo sapiens_hsa052030.76416386
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74665980
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.74649502
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.74295033
69Herpes simplex infection_Homo sapiens_hsa051680.73162412
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72814475
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.72002899
72Butanoate metabolism_Homo sapiens_hsa006500.71996346
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70152634
74Fat digestion and absorption_Homo sapiens_hsa049750.67925078
75Hippo signaling pathway_Homo sapiens_hsa043900.67053612
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66889232
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62625764
78Basal cell carcinoma_Homo sapiens_hsa052170.58680092
79Sulfur metabolism_Homo sapiens_hsa009200.58238157
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58116762
81Glutathione metabolism_Homo sapiens_hsa004800.55948023
82Steroid biosynthesis_Homo sapiens_hsa001000.55345921
83TGF-beta signaling pathway_Homo sapiens_hsa043500.55242813
84beta-Alanine metabolism_Homo sapiens_hsa004100.54899619
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54408377
86Histidine metabolism_Homo sapiens_hsa003400.54141482
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54063374
88Morphine addiction_Homo sapiens_hsa050320.53389111
89MicroRNAs in cancer_Homo sapiens_hsa052060.51082156
90Peroxisome_Homo sapiens_hsa041460.50554136
91HTLV-I infection_Homo sapiens_hsa051660.47453232
92Regulation of autophagy_Homo sapiens_hsa041400.47261454
93Glycerolipid metabolism_Homo sapiens_hsa005610.45988939
94Pentose phosphate pathway_Homo sapiens_hsa000300.45437953
95Serotonergic synapse_Homo sapiens_hsa047260.45381733
96Notch signaling pathway_Homo sapiens_hsa043300.44856863
97Huntingtons disease_Homo sapiens_hsa050160.43286460
98Antigen processing and presentation_Homo sapiens_hsa046120.42866878
99Arginine and proline metabolism_Homo sapiens_hsa003300.41921532
100Arachidonic acid metabolism_Homo sapiens_hsa005900.41397962
101Galactose metabolism_Homo sapiens_hsa000520.38884496
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37885938
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37503057
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36264978
105Alcoholism_Homo sapiens_hsa050340.34250497
106Insulin secretion_Homo sapiens_hsa049110.33640536
107Hedgehog signaling pathway_Homo sapiens_hsa043400.33215875
108Carbon metabolism_Homo sapiens_hsa012000.32741388
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32359260
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31232132
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30677025
112Legionellosis_Homo sapiens_hsa051340.30425516
113Thyroid cancer_Homo sapiens_hsa052160.29067202
114Tight junction_Homo sapiens_hsa045300.27360795
115Metabolic pathways_Homo sapiens_hsa011000.24863745
116Adherens junction_Homo sapiens_hsa045200.24698192
117Small cell lung cancer_Homo sapiens_hsa052220.24660833
118Linoleic acid metabolism_Homo sapiens_hsa005910.24504367
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23940770
120Pathways in cancer_Homo sapiens_hsa052000.20651462
121Colorectal cancer_Homo sapiens_hsa052100.17129080
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16821858
123Apoptosis_Homo sapiens_hsa042100.16176711
124mTOR signaling pathway_Homo sapiens_hsa041500.15631419
125Sulfur relay system_Homo sapiens_hsa041220.15264476
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.14294910
127Other glycan degradation_Homo sapiens_hsa005110.13145777
128Wnt signaling pathway_Homo sapiens_hsa043100.11843010
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11801425
130Melanoma_Homo sapiens_hsa052180.11428139
131Vitamin digestion and absorption_Homo sapiens_hsa049770.11343449
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10835650
133Bladder cancer_Homo sapiens_hsa052190.09871796
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.08353465
135HIF-1 signaling pathway_Homo sapiens_hsa040660.07835696
136Renin-angiotensin system_Homo sapiens_hsa046140.07691045
137Graft-versus-host disease_Homo sapiens_hsa053320.06208531
138Lysine degradation_Homo sapiens_hsa003100.05715668
139Influenza A_Homo sapiens_hsa051640.04412110
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03808132
141Prostate cancer_Homo sapiens_hsa052150.02859990
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.02369105
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.00308089
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.00270009

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