TRIO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.91040980
2hemidesmosome assembly (GO:0031581)4.17696866
3cell adhesion mediated by integrin (GO:0033627)4.09882018
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.05330085
5cell-substrate junction assembly (GO:0007044)3.91354018
6synaptic vesicle maturation (GO:0016188)3.84698984
7layer formation in cerebral cortex (GO:0021819)3.83749841
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.66632499
9dendrite morphogenesis (GO:0048813)3.64309713
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.57256677
11adherens junction assembly (GO:0034333)3.55922285
12vocalization behavior (GO:0071625)3.54264522
13skin morphogenesis (GO:0043589)3.53325603
14focal adhesion assembly (GO:0048041)3.52775071
15cell-substrate adherens junction assembly (GO:0007045)3.52775071
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.50183942
17establishment of nucleus localization (GO:0040023)3.49610258
18exploration behavior (GO:0035640)3.47477236
19dendritic spine morphogenesis (GO:0060997)3.39238765
20negative regulation of fatty acid transport (GO:2000192)3.33005881
21regulation of glutamate receptor signaling pathway (GO:1900449)3.32083499
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.25928789
23axonal fasciculation (GO:0007413)3.25426441
24collagen fibril organization (GO:0030199)3.24761572
25endodermal cell differentiation (GO:0035987)3.24620450
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.20103731
27cerebellar Purkinje cell differentiation (GO:0021702)3.13977789
28plasma membrane repair (GO:0001778)3.11096483
29protein localization to endosome (GO:0036010)3.09663336
30regulation of synapse structural plasticity (GO:0051823)3.08283208
31dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.05282074
32retina vasculature morphogenesis in camera-type eye (GO:0061299)3.01120989
33neuron recognition (GO:0008038)2.94619299
34substrate-dependent cell migration (GO:0006929)2.94542237
35cell migration involved in sprouting angiogenesis (GO:0002042)2.94041908
36regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.93908965
37sodium ion export (GO:0071436)2.93693922
38neuron cell-cell adhesion (GO:0007158)2.93276615
39positive regulation of blood vessel endothelial cell migration (GO:0043536)2.92827807
40glutamate secretion (GO:0014047)2.89981031
41paraxial mesoderm development (GO:0048339)2.88513794
42insulin-like growth factor receptor signaling pathway (GO:0048009)2.87911384
43vascular endothelial growth factor signaling pathway (GO:0038084)2.87812592
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87401963
45synaptic vesicle exocytosis (GO:0016079)2.86373751
46cytoskeletal anchoring at plasma membrane (GO:0007016)2.86306593
47cell communication by electrical coupling (GO:0010644)2.85606082
48glutamate receptor signaling pathway (GO:0007215)2.83921287
49regulation of synaptic vesicle exocytosis (GO:2000300)2.83489587
50neuromuscular process controlling balance (GO:0050885)2.80558406
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.80160286
52regulation of long-term neuronal synaptic plasticity (GO:0048169)2.80065209
53activation of protein kinase A activity (GO:0034199)2.79259717
54positive regulation of synapse maturation (GO:0090129)2.78268576
55basement membrane organization (GO:0071711)2.77568855
56proline transport (GO:0015824)2.76795122
57kidney mesenchyme development (GO:0072074)2.76574965
58regulation of ARF protein signal transduction (GO:0032012)2.74151984
59planar cell polarity pathway involved in neural tube closure (GO:0090179)2.73134653
60protein localization to synapse (GO:0035418)2.72951874
61chondrocyte proliferation (GO:0035988)2.72448064
62regulation of neuronal synaptic plasticity (GO:0048168)2.72066324
63hippo signaling (GO:0035329)2.71642938
64cell migration in hindbrain (GO:0021535)2.69700812
65neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.69590410
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68525440
67central nervous system projection neuron axonogenesis (GO:0021952)2.68076713
68cellular potassium ion homeostasis (GO:0030007)2.66227510
69vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.66114321
70innervation (GO:0060384)2.65828545
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65539303
72endothelial cell morphogenesis (GO:0001886)2.65092548
73synaptic transmission, glutamatergic (GO:0035249)2.64302447
74actin filament depolymerization (GO:0030042)2.63949068
75regulation of dendritic spine morphogenesis (GO:0061001)2.63724394
76negative regulation of chondrocyte differentiation (GO:0032331)2.63409203
77neurotransmitter secretion (GO:0007269)2.63244763
78synaptic vesicle endocytosis (GO:0048488)2.62658743
79positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.62466514
80regulation of transforming growth factor beta2 production (GO:0032909)2.62417642
81protein heterotrimerization (GO:0070208)2.60734773
82axon extension involved in axon guidance (GO:0048846)2.60222536
83neuron projection extension involved in neuron projection guidance (GO:1902284)2.60222536
84cytoplasmic mRNA processing body assembly (GO:0033962)2.60006976
85epithelial cell-cell adhesion (GO:0090136)2.59862828
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58933701
87wound healing, spreading of epidermal cells (GO:0035313)2.57628987
88positive regulation of fibroblast migration (GO:0010763)2.56380347
89blood vessel endothelial cell migration (GO:0043534)2.55147383
90hypotonic response (GO:0006971)2.54827709
91bone trabecula formation (GO:0060346)2.54335595
92axon extension (GO:0048675)2.53494966
93gamma-aminobutyric acid transport (GO:0015812)2.52363057
94nerve growth factor signaling pathway (GO:0038180)2.51874593
95regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51856744
96negative regulation of anoikis (GO:2000811)2.51107179
97vesicle transport along microtubule (GO:0047496)2.50974856
98regulation of excitatory postsynaptic membrane potential (GO:0060079)2.50682231
99mesenchymal-epithelial cell signaling (GO:0060638)2.50321858
100cell migration involved in heart development (GO:0060973)2.50030824
101regulation of clathrin-mediated endocytosis (GO:2000369)2.49952896
102regulation of glucose import in response to insulin stimulus (GO:2001273)2.49586829
103semaphorin-plexin signaling pathway (GO:0071526)2.49271310
104nuclear pore complex assembly (GO:0051292)2.49004897
105nucleus localization (GO:0051647)2.48905970
106regulation of axon extension involved in axon guidance (GO:0048841)2.46885228
107clathrin coat assembly (GO:0048268)2.46699537
108heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.46367584
109dermatan sulfate metabolic process (GO:0030205)2.45489072
110long-term memory (GO:0007616)2.45138814
111metanephric mesenchyme development (GO:0072075)2.44539939
112pericardium development (GO:0060039)2.44192771
113regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.43888569
114regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.43042348
115cerebellar granule cell differentiation (GO:0021707)2.43035951
116collagen metabolic process (GO:0032963)2.42750320
117positive regulation of osteoblast proliferation (GO:0033690)2.41960888
118regulation of postsynaptic membrane potential (GO:0060078)2.41065979
119coronary vasculature morphogenesis (GO:0060977)2.41012703
120dendritic spine organization (GO:0097061)2.40737904
121negative regulation of osteoblast proliferation (GO:0033689)2.40537698
122regulation of synaptic vesicle transport (GO:1902803)2.40345739
123dermatan sulfate biosynthetic process (GO:0030208)2.40168226
124membrane depolarization during action potential (GO:0086010)2.39625826
125wound healing, spreading of cells (GO:0044319)2.38956415
126endothelial cell chemotaxis (GO:0035767)2.38947032
127neurotransmitter-gated ion channel clustering (GO:0072578)2.38577205
128venous blood vessel morphogenesis (GO:0048845)2.38442323
129stress fiber assembly (GO:0043149)2.38360817
130mesodermal cell differentiation (GO:0048333)2.37528548
131glucocorticoid receptor signaling pathway (GO:0042921)2.37170060
132regulation of NFAT protein import into nucleus (GO:0051532)2.36001300
133regulation of axon guidance (GO:1902667)2.35557397
134COPI coating of Golgi vesicle (GO:0048205)2.35524627
135Golgi transport vesicle coating (GO:0048200)2.35524627
136neuronal ion channel clustering (GO:0045161)2.34105974
137myelination in peripheral nervous system (GO:0022011)2.33921779
138peripheral nervous system axon ensheathment (GO:0032292)2.33921779
139activation of Rac GTPase activity (GO:0032863)2.33394013
140barbed-end actin filament capping (GO:0051016)2.32986598
141establishment of spindle localization (GO:0051293)2.32577645
142regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.31850483
143substrate adhesion-dependent cell spreading (GO:0034446)2.31827776
144regulation of neuron migration (GO:2001222)2.31396712
145eye morphogenesis (GO:0048592)2.30992472
146cortical actin cytoskeleton organization (GO:0030866)2.29899195
147positive regulation of axon extension (GO:0045773)2.29694756
148prepulse inhibition (GO:0060134)2.29107282
149camera-type eye morphogenesis (GO:0048593)2.29034229
150multicellular organismal macromolecule metabolic process (GO:0044259)2.28808779
151auditory behavior (GO:0031223)2.28367068
152actin cytoskeleton reorganization (GO:0031532)2.28325800
153chondrocyte development (GO:0002063)2.27809677
154lymphangiogenesis (GO:0001946)2.27467601
155synapse organization (GO:0050808)2.27289326
156neuron-neuron synaptic transmission (GO:0007270)2.26885349
157morphogenesis of an epithelial sheet (GO:0002011)2.26813945
158positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.25841963
159neuron projection extension (GO:1990138)2.25779053
160regulation of hippo signaling (GO:0035330)2.25603287
161myoblast fusion (GO:0007520)2.25435973
162protein targeting to plasma membrane (GO:0072661)2.24905068
163adherens junction organization (GO:0034332)2.24720599
164collagen catabolic process (GO:0030574)2.24476247
165cerebellar Purkinje cell layer development (GO:0021680)2.24466679
166negative regulation of catenin import into nucleus (GO:0035414)2.23898174
167protein retention in ER lumen (GO:0006621)2.23372880
168regulation of synaptic plasticity (GO:0048167)2.22923620
169L-amino acid import (GO:0043092)2.22466738
170postsynaptic membrane organization (GO:0001941)2.22331741
171inner ear receptor cell development (GO:0060119)2.22059301
172regulation of dendritic spine development (GO:0060998)2.21443726
173cellular response to vitamin (GO:0071295)2.21375489
174sequestering of extracellular ligand from receptor (GO:0035581)2.21133715
175SMAD protein complex assembly (GO:0007183)2.21093366
176actin filament bundle organization (GO:0061572)2.20788020
177actin filament bundle assembly (GO:0051017)2.20788020
178suckling behavior (GO:0001967)2.20735636
179regulation of ARF GTPase activity (GO:0032312)2.20625479
180chemosensory behavior (GO:0007635)2.20309195
181regulation of synaptic transmission, glutamatergic (GO:0051966)2.18809416
182response to auditory stimulus (GO:0010996)2.17369516
183organelle transport along microtubule (GO:0072384)2.16956578
184cell differentiation in hindbrain (GO:0021533)2.16102020
185neuron projection morphogenesis (GO:0048812)2.15768503
186membrane depolarization (GO:0051899)2.15681053
187glial cell proliferation (GO:0014009)2.15503984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.94860342
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.86387464
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61112788
4GBX2_23144817_ChIP-Seq_PC3_Human2.57266380
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38212366
6* DROSHA_22980978_ChIP-Seq_HELA_Human2.37537307
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27636335
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27636335
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27036195
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26205640
11* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25736545
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.04968026
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02998067
14* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01471297
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97888773
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.96376744
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96285125
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95197633
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94486428
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93917700
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92241909
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91062712
23* BRD4_25478319_ChIP-Seq_HGPS_Human1.90318641
24CLOCK_20551151_ChIP-Seq_293T_Human1.89754246
25* EZH2_27304074_Chip-Seq_ESCs_Mouse1.88118628
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.87484853
27SOX9_24532713_ChIP-Seq_HFSC_Mouse1.85438171
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82808301
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.82370973
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.81480060
31* RARB_27405468_Chip-Seq_BRAIN_Mouse1.78680098
32* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77546289
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.74264932
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.74264932
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73519299
36* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.72021613
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71179439
38* EZH2_27294783_Chip-Seq_ESCs_Mouse1.66931166
39AR_21572438_ChIP-Seq_LNCaP_Human1.66638987
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64440885
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.63463545
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62873924
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61914087
44TP53_16413492_ChIP-PET_HCT116_Human1.60774678
45* CJUN_26792858_Chip-Seq_BT549_Human1.60545361
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59585251
47* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56946441
48* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56917162
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56205819
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.55565586
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52896188
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52684593
53* REST_21632747_ChIP-Seq_MESCs_Mouse1.51934484
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51478295
55* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.50261081
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50133298
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48432419
58* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47613407
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.46706745
60* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45721775
61KDM2B_26808549_Chip-Seq_K562_Human1.45586703
62* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44711901
63* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44553649
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43895982
65TP53_22127205_ChIP-Seq_IMR90_Human1.43623233
66SMAD4_21799915_ChIP-Seq_A2780_Human1.42877554
67* AHR_22903824_ChIP-Seq_MCF-7_Human1.42657267
68* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41676611
69* ARNT_22903824_ChIP-Seq_MCF-7_Human1.39467711
70UBF1/2_26484160_Chip-Seq_HMECs_Human1.37631571
71* TP53_23651856_ChIP-Seq_MEFs_Mouse1.36631304
72FOXM1_23109430_ChIP-Seq_U2OS_Human1.36238252
73* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36046722
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34707954
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34222707
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.33561438
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.32305969
78* AR_19668381_ChIP-Seq_PC3_Human1.32217956
79* TBX20_22328084_ChIP-Seq_HEART_Mouse1.31823289
80* TBX20_22080862_ChIP-Seq_HEART_Mouse1.31823289
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31333106
82* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30699615
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30627346
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27456032
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27325384
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27119988
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26796736
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26164858
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26125394
90* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25025859
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24600014
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.24168144
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21060534
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21060534
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20921024
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20412682
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20408383
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20289060
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.19593412
100* STAT3_23295773_ChIP-Seq_U87_Human1.19061337
101* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18629016
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18503686
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.18081050
104TRIM28_21343339_ChIP-Seq_HEK293_Human1.17621208
105KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16921818
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16328644
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16226477
108ISL1_27105846_Chip-Seq_CPCs_Mouse1.16177901
109* ZNF274_21170338_ChIP-Seq_K562_Hela1.15544512
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14990098
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14864746
112RXR_22108803_ChIP-Seq_LS180_Human1.14228641
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14201686
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.14117450
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11818128
116ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10830487
117* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10721216
118ERG_21242973_ChIP-ChIP_JURKAT_Human1.09224331
119REST_18959480_ChIP-ChIP_MESCs_Mouse1.08945384
120* TCF7_22412390_ChIP-Seq_EML_Mouse1.08940095
121RACK7_27058665_Chip-Seq_MCF-7_Human1.08507249
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07538427
123SMAD3_21741376_ChIP-Seq_HESCs_Human1.07426272
124* FOXA2_19822575_ChIP-Seq_HepG2_Human1.07244312
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07108046
126TP53_18474530_ChIP-ChIP_U2OS_Human1.06969290
127SMAD4_21741376_ChIP-Seq_HESCs_Human1.05879945
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05582051
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05157119
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02639669
131SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02358274
132FOXO3_23340844_ChIP-Seq_DLD1_Human1.01915844
133KDM2B_26808549_Chip-Seq_JURKAT_Human1.01808891
134CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01653662
135NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01090341
136JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00999579
137* TCF4_23295773_ChIP-Seq_U87_Human1.00913007
138TCF4_18268006_ChIP-ChIP_LS174T_Human1.00893958
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00523646
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00523646
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00478915
142* AR_25329375_ChIP-Seq_VCAP_Human1.00196623
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00171193
144SMAD3_21741376_ChIP-Seq_ESCs_Human0.99569785
145ZNF263_19887448_ChIP-Seq_K562_Human0.99489404
146* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97884026
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97135064
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96935000
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.96072361
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.96033677
151SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95472831
152SALL1_21062744_ChIP-ChIP_HESCs_Human0.95239363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.19346342
2MP0000569_abnormal_digit_pigmentation5.03348669
3MP0003566_abnormal_cell_adhesion2.90870001
4MP0003635_abnormal_synaptic_transmissio2.86773594
5MP0004270_analgesia2.72752675
6MP0009780_abnormal_chondrocyte_physiolo2.55873883
7MP0010352_gastrointestinal_tract_polyps2.39667664
8MP0003950_abnormal_plasma_membrane2.38709391
9MP0009046_muscle_twitch2.29097558
10MP0002063_abnormal_learning/memory/cond2.21060903
11MP0010368_abnormal_lymphatic_system2.12083879
12MP0005409_darkened_coat_color2.09423967
13MP0001299_abnormal_eye_distance/1.99141773
14MP0003705_abnormal_hypodermis_morpholog1.98201488
15MP0005023_abnormal_wound_healing1.97146212
16MP0004858_abnormal_nervous_system1.96678739
17MP0003880_abnormal_central_pattern1.94166793
18MP0005623_abnormal_meninges_morphology1.93459922
19MP0009745_abnormal_behavioral_response1.92255566
20MP0000778_abnormal_nervous_system1.91609397
21MP0009384_cardiac_valve_regurgitation1.88585929
22MP0004145_abnormal_muscle_electrophysio1.88510424
23MP0002064_seizures1.86144774
24MP0003283_abnormal_digestive_organ1.79990770
25MP0003122_maternal_imprinting1.76796004
26MP0008438_abnormal_cutaneous_collagen1.70940637
27MP0001348_abnormal_lacrimal_gland1.70261357
28MP0002572_abnormal_emotion/affect_behav1.69153313
29MP0000751_myopathy1.68063412
30MP0000767_abnormal_smooth_muscle1.64758597
31MP0005423_abnormal_somatic_nervous1.63511733
32MP0003045_fibrosis1.62930633
33MP0003787_abnormal_imprinting1.62284416
34MP0001849_ear_inflammation1.60691811
35MP0002060_abnormal_skin_morphology1.59985604
36MP0002734_abnormal_mechanical_nocicepti1.58373264
37MP0002184_abnormal_innervation1.55855470
38MP0005076_abnormal_cell_differentiation1.53901999
39MP0003941_abnormal_skin_development1.49933190
40MP0001486_abnormal_startle_reflex1.49003616
41MP0003172_abnormal_lysosome_physiology1.44882023
42MP0003385_abnormal_body_wall1.42484227
43MP0004510_myositis1.41570477
44MP0002909_abnormal_adrenal_gland1.41295836
45MP0008569_lethality_at_weaning1.38527121
46* MP0004811_abnormal_neuron_physiology1.37301972
47MP0001968_abnormal_touch/_nociception1.37231591
48MP0004233_abnormal_muscle_weight1.33414063
49MP0000762_abnormal_tongue_morphology1.32026888
50MP0003091_abnormal_cell_migration1.32013308
51MP0001440_abnormal_grooming_behavior1.31681656
52MP0005503_abnormal_tendon_morphology1.29300585
53MP0001879_abnormal_lymphatic_vessel1.27648064
54MP0000955_abnormal_spinal_cord1.27305669
55MP0005257_abnormal_intraocular_pressure1.27136701
56MP0002067_abnormal_sensory_capabilities1.24050611
57MP0010030_abnormal_orbit_morphology1.23599341
58MP0002272_abnormal_nervous_system1.22936562
59MP0008961_abnormal_basal_metabolism1.22044529
60MP0000534_abnormal_ureter_morphology1.20206257
61* MP0000759_abnormal_skeletal_muscle1.18669145
62MP0000749_muscle_degeneration1.18359060
63MP0005187_abnormal_penis_morphology1.17899515
64MP0002557_abnormal_social/conspecific_i1.17310136
65MP0005508_abnormal_skeleton_morphology1.16513019
66* MP0000733_abnormal_muscle_development1.12436915
67MP0004272_abnormal_basement_membrane1.11009941
68MP0001958_emphysema1.10876163
69MP0001915_intracranial_hemorrhage1.06868405
70MP0002108_abnormal_muscle_morphology1.06805060
71MP0002882_abnormal_neuron_morphology1.04755268
72MP0001501_abnormal_sleep_pattern1.04267968
73MP0009053_abnormal_anal_canal1.03017567
74MP0004885_abnormal_endolymph1.01750026
75MP0006138_congestive_heart_failure1.01193093
76MP0002733_abnormal_thermal_nociception1.01117671
77MP0006054_spinal_hemorrhage1.00506294
78MP0002089_abnormal_postnatal_growth/wei1.00494870
79* MP0002152_abnormal_brain_morphology1.00471945
80MP0002896_abnormal_bone_mineralization1.00236207
81MP0004924_abnormal_behavior1.00124443
82MP0005386_behavior/neurological_phenoty1.00124443
83MP0001177_atelectasis0.99751720
84MP0005595_abnormal_vascular_smooth0.99260321
85MP0004185_abnormal_adipocyte_glucose0.98761052
86MP0003121_genomic_imprinting0.98667967
87MP0010234_abnormal_vibrissa_follicle0.97285425
88MP0004084_abnormal_cardiac_muscle0.96195927
89MP0003115_abnormal_respiratory_system0.95727450
90MP0000432_abnormal_head_morphology0.94876917
91MP0000428_abnormal_craniofacial_morphol0.93380476
92MP0000579_abnormal_nail_morphology0.92015143
93MP0000537_abnormal_urethra_morphology0.91997782
94MP0001970_abnormal_pain_threshold0.91407512
95MP0003300_gastrointestinal_ulcer0.90866040
96MP0005248_abnormal_Harderian_gland0.90598027
97MP0002234_abnormal_pharynx_morphology0.90439047
98MP0005275_abnormal_skin_tensile0.90315706
99MP0005375_adipose_tissue_phenotype0.89484085
100MP0000462_abnormal_digestive_system0.89461395
101MP0005621_abnormal_cell_physiology0.89092428
102MP0002697_abnormal_eye_size0.89031665
103MP0002269_muscular_atrophy0.88957952
104MP0003633_abnormal_nervous_system0.88065278
105MP0003935_abnormal_craniofacial_develop0.87618789
106MP0002925_abnormal_cardiovascular_devel0.87318102
107MP0002066_abnormal_motor_capabilities/c0.86803669
108MP0005197_abnormal_uvea_morphology0.86593206
109MP0003453_abnormal_keratinocyte_physiol0.86152833
110MP0002735_abnormal_chemical_nociception0.85683748
111MP0004134_abnormal_chest_morphology0.85634222
112MP0001243_abnormal_dermal_layer0.85503044
113MP0000013_abnormal_adipose_tissue0.83409000
114MP0003634_abnormal_glial_cell0.83278987
115MP0003861_abnormal_nervous_system0.82690995
116MP0005171_absent_coat_pigmentation0.81020780
117MP0002736_abnormal_nociception_after0.80949340
118MP0002114_abnormal_axial_skeleton0.80860024
119MP0002128_abnormal_blood_circulation0.80819985
120MP0002877_abnormal_melanocyte_morpholog0.80320804
121* MP0004087_abnormal_muscle_fiber0.79437933
122MP0003942_abnormal_urinary_system0.79392953
123MP0010630_abnormal_cardiac_muscle0.79230410
124MP0004085_abnormal_heartbeat0.78765929
125MP0001614_abnormal_blood_vessel0.78353627
126MP0003755_abnormal_palate_morphology0.77473616
127MP0004130_abnormal_muscle_cell0.76958511
128MP0003329_amyloid_beta_deposits0.76586865
129MP0004036_abnormal_muscle_relaxation0.76541172
130MP0002092_abnormal_eye_morphology0.76035596
131MP0003632_abnormal_nervous_system0.75500844
132MP0003279_aneurysm0.74775697
133MP0003690_abnormal_glial_cell0.74582258
134MP0003631_nervous_system_phenotype0.74516693
135MP0000003_abnormal_adipose_tissue0.73971780
136MP0002116_abnormal_craniofacial_bone0.73460963
137MP0002168_other_aberrant_phenotype0.73383932
138MP0004215_abnormal_myocardial_fiber0.72033830
139MP0010307_abnormal_tumor_latency0.70585071
140MP0003137_abnormal_impulse_conducting0.70306848
141MP0001542_abnormal_bone_strength0.70255461
142MP0002332_abnormal_exercise_endurance0.68269156
143MP0009250_abnormal_appendicular_skeleto0.68173198
144MP0005367_renal/urinary_system_phenotyp0.67582585
145MP0000516_abnormal_urinary_system0.67582585
146MP0000747_muscle_weakness0.66888030
147MP0002295_abnormal_pulmonary_circulatio0.66690575
148MP0000467_abnormal_esophagus_morphology0.66523750
149MP0003937_abnormal_limbs/digits/tail_de0.65386314
150MP0002932_abnormal_joint_morphology0.65296083
151MP0002177_abnormal_outer_ear0.65046763
152MP0000163_abnormal_cartilage_morphology0.64599652
153MP0002086_abnormal_extraembryonic_tissu0.64377761
154MP0004808_abnormal_hematopoietic_stem0.63950372

Predicted human phenotypes

RankGene SetZ-score
1Aortic dissection (HP:0002647)3.60832025
2Shallow orbits (HP:0000586)3.21768965
3Focal seizures (HP:0007359)3.09526376
4Focal motor seizures (HP:0011153)2.97018030
5Fragile skin (HP:0001030)2.95884824
6Broad face (HP:0000283)2.94751951
7Action tremor (HP:0002345)2.88726607
8Ulnar bowing (HP:0003031)2.84546897
9Wormian bones (HP:0002645)2.84361813
10Cerebral aneurysm (HP:0004944)2.76857821
11Neonatal short-limb short stature (HP:0008921)2.71681181
12Short 4th metacarpal (HP:0010044)2.71499400
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71499400
14Cervical subluxation (HP:0003308)2.70810004
15Macroorchidism (HP:0000053)2.67228301
16Genetic anticipation (HP:0003743)2.65716932
17Spinal rigidity (HP:0003306)2.56057050
18Short nail (HP:0001799)2.54563515
19Osteolytic defects of the hand bones (HP:0009699)2.54440705
20Osteolytic defects of the phalanges of the hand (HP:0009771)2.54440705
21Progressive cerebellar ataxia (HP:0002073)2.52221122
22Increased connective tissue (HP:0009025)2.47663730
23Spondylolisthesis (HP:0003302)2.41492405
24Visual hallucinations (HP:0002367)2.38929409
25Soft skin (HP:0000977)2.38916950
26Mitral regurgitation (HP:0001653)2.37669147
27Abnormality of dentin (HP:0010299)2.34667225
28Myokymia (HP:0002411)2.33931293
29Broad metatarsal (HP:0001783)2.27137115
30Lower limb amyotrophy (HP:0007210)2.27038624
31Aqueductal stenosis (HP:0002410)2.26848802
32Type 1 muscle fiber predominance (HP:0003803)2.24656756
33Wide anterior fontanel (HP:0000260)2.21632428
34Aortic regurgitation (HP:0001659)2.20946340
35Syringomyelia (HP:0003396)2.19637144
36Spinal cord lesions (HP:0100561)2.19637144
37Narrow palate (HP:0000189)2.19570155
38Natal tooth (HP:0000695)2.19428336
39Pointed chin (HP:0000307)2.19230757
40Absent frontal sinuses (HP:0002688)2.15636558
41Hyperacusis (HP:0010780)2.13706521
42Drooling (HP:0002307)2.13615879
43Excessive salivation (HP:0003781)2.13615879
44Blue sclerae (HP:0000592)2.09555302
45Joint laxity (HP:0001388)2.07988309
46Protrusio acetabuli (HP:0003179)2.07669559
47Overgrowth (HP:0001548)2.06530623
48Abnormality of the distal phalanx of the thumb (HP:0009617)2.05526503
49Broad-based gait (HP:0002136)2.04846392
50Hemiplegia (HP:0002301)2.04589580
51Abnormality of the 4th metacarpal (HP:0010012)2.03516796
52Vertebral compression fractures (HP:0002953)2.02766047
53Mitral valve prolapse (HP:0001634)2.01995125
54Epileptic encephalopathy (HP:0200134)2.01838836
55Vertebral arch anomaly (HP:0008438)2.01108926
56Urinary bladder sphincter dysfunction (HP:0002839)1.99562899
57Difficulty climbing stairs (HP:0003551)1.99280882
58Atonic seizures (HP:0010819)1.98414811
59Dysmetric saccades (HP:0000641)1.98409414
60Disproportionate tall stature (HP:0001519)1.97780134
61Dislocated radial head (HP:0003083)1.97241729
62Biconcave vertebral bodies (HP:0004586)1.96340935
63Tibial bowing (HP:0002982)1.96088666
64Elfin facies (HP:0004428)1.95911309
65Urethral obstruction (HP:0000796)1.94586242
66Turricephaly (HP:0000262)1.94204712
67Elbow flexion contracture (HP:0002987)1.94076679
68Obstructive sleep apnea (HP:0002870)1.93595016
69Bladder diverticulum (HP:0000015)1.93440818
70Buphthalmos (HP:0000557)1.93424426
71Febrile seizures (HP:0002373)1.93165928
72Flat acetabular roof (HP:0003180)1.92905880
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92717534
74Neoplasm of the heart (HP:0100544)1.91672098
75Supranuclear gaze palsy (HP:0000605)1.89569353
76Gaze-evoked nystagmus (HP:0000640)1.88642025
77Dilatation of the ascending aorta (HP:0005111)1.87969326
78Mitral stenosis (HP:0001718)1.87575103
79Follicular hyperkeratosis (HP:0007502)1.86891497
80Hyperextensible skin (HP:0000974)1.86721759
81Heterotopia (HP:0002282)1.86430008
82Camptodactyly of toe (HP:0001836)1.86113411
83Long toe (HP:0010511)1.85248077
84Renovascular hypertension (HP:0100817)1.84838533
85Mild short stature (HP:0003502)1.83590258
86Lymphangioma (HP:0100764)1.83046993
87Wrist flexion contracture (HP:0001239)1.82931070
88Long eyelashes (HP:0000527)1.82798905
89Bowel diverticulosis (HP:0005222)1.82571068
90Arterial tortuosity (HP:0005116)1.81788087
91Limited hip movement (HP:0008800)1.81498584
92Renal duplication (HP:0000075)1.81305268
93Abnormality of the radial head (HP:0003995)1.80127629
94Impaired vibration sensation in the lower limbs (HP:0002166)1.79677784
95Hepatoblastoma (HP:0002884)1.79431366
96Thin bony cortex (HP:0002753)1.78700006
97Impaired smooth pursuit (HP:0007772)1.78687774
98Abnormal ossification of hand bones (HP:0005921)1.78358364
99Obsessive-compulsive behavior (HP:0000722)1.78314699
100Aortic aneurysm (HP:0004942)1.78060027
101Difficulty running (HP:0009046)1.77780578
102Subacute progressive viral hepatitis (HP:0006572)1.77399147
103Abnormality of the calcaneus (HP:0008364)1.75857015
104Bowing of the arm (HP:0006488)1.75609228
105Bowed forearm bones (HP:0003956)1.75609228
106Asymmetry of the thorax (HP:0001555)1.75370529
107Absence seizures (HP:0002121)1.74931244
108Achilles tendon contracture (HP:0001771)1.74643275
109Papilledema (HP:0001085)1.74344654
110Distal upper limb amyotrophy (HP:0007149)1.74150501
111Upper limb amyotrophy (HP:0009129)1.74150501
112Hypoplastic ischia (HP:0003175)1.73944203
113Abnormality of the acetabulum (HP:0003170)1.73678557
114Abnormal social behavior (HP:0012433)1.73001458
115Impaired social interactions (HP:0000735)1.73001458
116Advanced eruption of teeth (HP:0006288)1.72398965
117Vascular tortuosity (HP:0004948)1.72184516
118Scapular winging (HP:0003691)1.72141602
119Abnormality of the nasal septum (HP:0000419)1.70937171
120Enlarged penis (HP:0000040)1.70783134
121Truncal ataxia (HP:0002078)1.70538521
122Knee flexion contracture (HP:0006380)1.69616941
123Termporal pattern (HP:0011008)1.69327106
124Insidious onset (HP:0003587)1.69327106
125Insomnia (HP:0100785)1.69220769
126Distal lower limb amyotrophy (HP:0008944)1.68289530
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67142500
128Persistence of primary teeth (HP:0006335)1.66362360
129Dysdiadochokinesis (HP:0002075)1.66068031
130Broad ribs (HP:0000885)1.65985308
131Genu recurvatum (HP:0002816)1.65959080
132Midline defect of the nose (HP:0004122)1.65466677
133Trigonocephaly (HP:0000243)1.65394221
134Relative macrocephaly (HP:0004482)1.65340354
135Agitation (HP:0000713)1.65229043
136Abnormality of the lower motor neuron (HP:0002366)1.64391121
137Poor eye contact (HP:0000817)1.64297601
138Thoracolumbar scoliosis (HP:0002944)1.63873395
139Depression (HP:0000716)1.63407170
140Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63262625
141Mildly elevated creatine phosphokinase (HP:0008180)1.63094832
142Hypoplasia of the iris (HP:0007676)1.62752204
143Premature rupture of membranes (HP:0001788)1.62409114
144Inappropriate behavior (HP:0000719)1.62353669
145Absent speech (HP:0001344)1.61442195
146Ankyloglossia (HP:0010296)1.61097664
147Protruding ear (HP:0000411)1.60869685
148Aneurysm (HP:0002617)1.59963522
149Ankle contracture (HP:0006466)1.59378788
150Lower limb asymmetry (HP:0100559)1.59161735
151Flat cornea (HP:0007720)1.58804747
152Postural instability (HP:0002172)1.58742787
153Open mouth (HP:0000194)1.58691725
154Arnold-Chiari malformation (HP:0002308)1.57835333
155Abnormality of ocular smooth pursuit (HP:0000617)1.57718091
156Striae distensae (HP:0001065)1.57601447
157Round ear (HP:0100830)1.57561754
158Ankle clonus (HP:0011448)1.57469837
159Broad thumb (HP:0011304)1.57393525
160Arachnodactyly (HP:0001166)1.56400595
161Abnormality of skeletal muscle fiber size (HP:0012084)1.56067084
162Hypoventilation (HP:0002791)1.55981859
163Increased variability in muscle fiber diameter (HP:0003557)1.54845756
164Exostoses (HP:0100777)1.53729064
165Atrophic scars (HP:0001075)1.53569516
166Deviation of the hallux (HP:0010051)1.53324218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.17984424
2MARK12.89811044
3MAP3K92.56304787
4EPHA42.45998478
5CAMK1G2.42299018
6MET2.36970287
7RIPK12.34034035
8MST1R2.19832009
9MAP3K42.19452974
10EEF2K2.12191288
11SIK22.08982628
12NTRK21.94946944
13PAK61.92728287
14TYRO31.91263140
15CAMK1D1.88044380
16PDGFRA1.86954430
17TRIB31.84861927
18PRKD31.84570186
19CAMKK11.82108573
20DAPK21.81125612
21AKT31.79747463
22ERBB41.74606057
23TTN1.73586765
24DDR21.67777092
25EPHA21.66108508
26NEK91.62551880
27MINK11.61037621
28DMPK1.58277488
29TRPM71.54867476
30KSR11.53598052
31LATS11.47506814
32IRAK31.45654086
33NTRK11.42429179
34MYLK1.30580035
35ICK1.29021689
36STK381.27168894
37PTK61.23631309
38RET1.21058918
39PDGFRB1.20870878
40SMG11.18009307
41KSR21.17623847
42LATS21.17330147
43PKN21.16276471
44SGK31.15974202
45CAMKK21.15953761
46MELK1.15678517
47MAP3K61.15055422
48FES1.15016325
49FGFR21.13043168
50CDK51.12301162
51RIPK41.11499400
52SIK11.10303190
53MAP3K21.07619167
54PRKCH1.07568919
55SGK21.02471591
56MOS1.02165228
57SCYL21.02147712
58MAP2K41.01089912
59MARK21.00214791
60MAPK130.98264287
61FGFR40.97637945
62CDC42BPA0.95844807
63STK110.91638218
64PHKG10.91260967
65PHKG20.91260967
66WNK10.91196119
67PAK30.91024033
68TAOK10.90608096
69SGK10.90017985
70PRKD20.89419131
71PAK40.88688238
72PNCK0.88153648
73BMX0.83976695
74INSRR0.83394159
75PLK20.83080424
76ALK0.81351505
77MTOR0.80488297
78SGK2230.78940426
79SGK4940.78940426
80MAP2K70.75400369
81TGFBR20.75157954
82TNIK0.75128302
83FER0.75093803
84CAMK40.74504541
85MAPK110.74443847
86EPHB20.73613822
87CDK120.73396405
88PTK2B0.73366700
89FLT30.72944105
90ERBB30.72695959
91ERBB20.71432811
92MAP3K100.70426784
93MAP3K70.69675783
94FGFR10.68893969
95ROCK10.68427038
96EPHB10.68134765
97CASK0.65386374
98ROCK20.64805955
99MAP2K30.64168299
100RPS6KA20.63519416
101CDK80.61549540
102FYN0.60837265
103CAMK10.60226790
104PRKCG0.58728570
105UHMK10.57804205
106RPS6KA30.57588369
107PAK20.57021124
108MAPK100.56736977
109JAK10.56507416
110PRPF4B0.54639954
111ERN10.54212584
112FGFR30.53364112
113BRD40.53266511
114PRKCZ0.51451645
115MAP3K130.50949091
116CDK90.50188769
117LMTK20.49921081
118* PTK20.49835359
119LIMK10.48167907
120SRC0.47819685
121CAMK2A0.47813519
122DAPK10.47384296
123MAPK80.46499615
124CDK150.46462726
125CDK180.45715492
126MAPK70.44552700
127PKN10.44507751
128CAMK2B0.44354314
129STK38L0.43643021
130PDPK10.43152684
131GSK3A0.43137761
132CDK60.42944453
133PRKD10.41378746
134ILK0.40105905
135CAMK2G0.37575772
136RPS6KL10.36723686
137RPS6KC10.36723686
138NEK60.36196306
139PRKAA10.34243129
140MAP2K10.30695585
141MAPK10.30491720
142NEK20.27483517
143ABL20.26152224

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.03733269
2Circadian entrainment_Homo sapiens_hsa047131.88889121
3Long-term potentiation_Homo sapiens_hsa047201.88658073
4Glutamatergic synapse_Homo sapiens_hsa047241.80165417
5Type II diabetes mellitus_Homo sapiens_hsa049301.77839632
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65311495
7Small cell lung cancer_Homo sapiens_hsa052221.64209264
8Synaptic vesicle cycle_Homo sapiens_hsa047211.61774114
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60895727
10Olfactory transduction_Homo sapiens_hsa047401.59941664
11GABAergic synapse_Homo sapiens_hsa047271.58539986
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55144288
13Cholinergic synapse_Homo sapiens_hsa047251.54788282
14Salivary secretion_Homo sapiens_hsa049701.53827111
15Morphine addiction_Homo sapiens_hsa050321.51003666
16Amphetamine addiction_Homo sapiens_hsa050311.50687012
17Insulin secretion_Homo sapiens_hsa049111.49932823
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48660873
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48539603
20Dopaminergic synapse_Homo sapiens_hsa047281.45284203
21Glioma_Homo sapiens_hsa052141.44814920
22Bladder cancer_Homo sapiens_hsa052191.44564266
23Gastric acid secretion_Homo sapiens_hsa049711.41636855
24Axon guidance_Homo sapiens_hsa043601.40722362
25Oxytocin signaling pathway_Homo sapiens_hsa049211.39216987
26Dilated cardiomyopathy_Homo sapiens_hsa054141.37869289
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35584187
28GnRH signaling pathway_Homo sapiens_hsa049121.34691583
29Renin secretion_Homo sapiens_hsa049241.33151220
30Estrogen signaling pathway_Homo sapiens_hsa049151.30592202
31Long-term depression_Homo sapiens_hsa047301.29288985
32Gap junction_Homo sapiens_hsa045401.19945463
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18142458
34mTOR signaling pathway_Homo sapiens_hsa041501.17680569
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16854219
36Cocaine addiction_Homo sapiens_hsa050301.16592091
37cAMP signaling pathway_Homo sapiens_hsa040241.15275642
38Notch signaling pathway_Homo sapiens_hsa043301.13874799
39ErbB signaling pathway_Homo sapiens_hsa040121.13548415
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12366254
41Focal adhesion_Homo sapiens_hsa045101.09680490
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09249621
43Dorso-ventral axis formation_Homo sapiens_hsa043201.08794518
44Melanogenesis_Homo sapiens_hsa049161.07510636
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07175242
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.06222120
47Prostate cancer_Homo sapiens_hsa052151.06079151
48Endometrial cancer_Homo sapiens_hsa052131.06025453
49Calcium signaling pathway_Homo sapiens_hsa040201.05964614
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05650180
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03791968
52Taste transduction_Homo sapiens_hsa047421.03569622
53Proteoglycans in cancer_Homo sapiens_hsa052051.02987411
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02657587
55Phospholipase D signaling pathway_Homo sapiens_hsa040721.01622876
56Tight junction_Homo sapiens_hsa045301.01554863
57Protein digestion and absorption_Homo sapiens_hsa049741.00164743
58Pathways in cancer_Homo sapiens_hsa052000.98471695
59PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97935286
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96427800
61Prion diseases_Homo sapiens_hsa050200.96187325
62Thyroid cancer_Homo sapiens_hsa052160.95718911
63TGF-beta signaling pathway_Homo sapiens_hsa043500.93527677
64Chronic myeloid leukemia_Homo sapiens_hsa052200.93347933
65Adherens junction_Homo sapiens_hsa045200.92848250
66Serotonergic synapse_Homo sapiens_hsa047260.89660578
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89533808
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89504745
69Renal cell carcinoma_Homo sapiens_hsa052110.89292258
70MAPK signaling pathway_Homo sapiens_hsa040100.87946158
71ECM-receptor interaction_Homo sapiens_hsa045120.87792987
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87639057
73Choline metabolism in cancer_Homo sapiens_hsa052310.87301620
74Rap1 signaling pathway_Homo sapiens_hsa040150.84677295
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.84449998
76Colorectal cancer_Homo sapiens_hsa052100.84061979
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.81999350
78VEGF signaling pathway_Homo sapiens_hsa043700.81987982
79Non-small cell lung cancer_Homo sapiens_hsa052230.80087206
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.79814479
81MicroRNAs in cancer_Homo sapiens_hsa052060.78658938
82Amoebiasis_Homo sapiens_hsa051460.78244562
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77033460
84Thyroid hormone synthesis_Homo sapiens_hsa049180.76884674
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76806184
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76612700
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75842898
88AMPK signaling pathway_Homo sapiens_hsa041520.75638429
89Other glycan degradation_Homo sapiens_hsa005110.75165573
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73726142
91FoxO signaling pathway_Homo sapiens_hsa040680.73262643
92Wnt signaling pathway_Homo sapiens_hsa043100.72141615
93Insulin signaling pathway_Homo sapiens_hsa049100.71983189
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71710721
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71609137
96Pancreatic secretion_Homo sapiens_hsa049720.70554435
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70466387
98Hippo signaling pathway_Homo sapiens_hsa043900.70159479
99Basal cell carcinoma_Homo sapiens_hsa052170.70068128
100Platelet activation_Homo sapiens_hsa046110.69654109
101Hedgehog signaling pathway_Homo sapiens_hsa043400.69081989
102Insulin resistance_Homo sapiens_hsa049310.68940949
103Pancreatic cancer_Homo sapiens_hsa052120.68740014
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65418290
105Acute myeloid leukemia_Homo sapiens_hsa052210.64774966
106Ras signaling pathway_Homo sapiens_hsa040140.64392004
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64288522
108Glucagon signaling pathway_Homo sapiens_hsa049220.63982918
109Viral myocarditis_Homo sapiens_hsa054160.62779860
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.62703620
111Endocytosis_Homo sapiens_hsa041440.62363921
112HIF-1 signaling pathway_Homo sapiens_hsa040660.61686909
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61611378
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61316646
115TNF signaling pathway_Homo sapiens_hsa046680.61220712
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.60440670
117Inositol phosphate metabolism_Homo sapiens_hsa005620.59949994
118Prolactin signaling pathway_Homo sapiens_hsa049170.59930754
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59122474
120Lysine degradation_Homo sapiens_hsa003100.58865937
121Melanoma_Homo sapiens_hsa052180.58145672
122Salmonella infection_Homo sapiens_hsa051320.57569448
123Oocyte meiosis_Homo sapiens_hsa041140.55615530
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.54094271
125Toxoplasmosis_Homo sapiens_hsa051450.53390131

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