TRIP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of protein autophosphorylation (GO:0031954)4.09274030
2regulation of meiosis I (GO:0060631)3.77098293
3COPI coating of Golgi vesicle (GO:0048205)3.68332121
4Golgi transport vesicle coating (GO:0048200)3.68332121
5prenylation (GO:0097354)3.46868090
6protein prenylation (GO:0018342)3.46868090
7auditory receptor cell differentiation (GO:0042491)3.45472820
8regulation of protein glycosylation (GO:0060049)3.44972400
9regulation of DNA endoreduplication (GO:0032875)3.36752489
10protein targeting to lysosome (GO:0006622)3.35425049
11establishment of protein localization to vacuole (GO:0072666)3.35425049
12protein targeting to vacuole (GO:0006623)3.35425049
13COPII vesicle coating (GO:0048208)3.31824884
14mitotic sister chromatid cohesion (GO:0007064)3.26169499
15cytoplasmic mRNA processing body assembly (GO:0033962)3.25573025
16regulation of hexokinase activity (GO:1903299)3.19576536
17regulation of glucokinase activity (GO:0033131)3.19576536
18microtubule anchoring (GO:0034453)3.16685320
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07927120
20positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.05980041
21positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.05980041
22positive regulation of mitotic sister chromatid separation (GO:1901970)3.05980041
23embryonic retina morphogenesis in camera-type eye (GO:0060059)3.05086865
24interleukin-6-mediated signaling pathway (GO:0070102)3.01763156
25* protein targeting to Golgi (GO:0000042)2.99666739
26* retrograde transport, vesicle recycling within Golgi (GO:0000301)2.98188600
27exocrine pancreas development (GO:0031017)2.97334939
28monoubiquitinated protein deubiquitination (GO:0035520)2.96941152
29macroautophagy (GO:0016236)2.96464421
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.91920940
31pericardium development (GO:0060039)2.91486143
32negative regulation of hormone biosynthetic process (GO:0032353)2.88714427
33growth hormone receptor signaling pathway (GO:0060396)2.82726850
34* establishment of protein localization to Golgi (GO:0072600)2.80500833
35positive regulation of p38MAPK cascade (GO:1900745)2.80480284
36artery development (GO:0060840)2.78750852
37single strand break repair (GO:0000012)2.78365078
38negative regulation of DNA-dependent DNA replication (GO:2000104)2.78293120
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77178514
40telomere maintenance via telomerase (GO:0007004)2.76195203
41positive regulation of histone deacetylation (GO:0031065)2.74003597
42protein K11-linked deubiquitination (GO:0035871)2.72510875
43type B pancreatic cell development (GO:0003323)2.72195146
44regulation of acrosome reaction (GO:0060046)2.71074846
45sister chromatid cohesion (GO:0007062)2.70226004
46peptidyl-lysine trimethylation (GO:0018023)2.68830007
47ER overload response (GO:0006983)2.68805787
48piRNA metabolic process (GO:0034587)2.68648522
49regulation of keratinocyte proliferation (GO:0010837)2.66464379
50genitalia morphogenesis (GO:0035112)2.65230831
51replication fork processing (GO:0031297)2.65143855
52neural tube formation (GO:0001841)2.64804478
53coronary vasculature morphogenesis (GO:0060977)2.63875761
54synapsis (GO:0007129)2.61978655
55regulation of centriole replication (GO:0046599)2.61316444
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61298461
57snRNA transcription (GO:0009301)2.61073722
58sequestering of extracellular ligand from receptor (GO:0035581)2.60603605
59centriole replication (GO:0007099)2.60377088
60appendage development (GO:0048736)2.59570478
61limb development (GO:0060173)2.59570478
62intraciliary transport (GO:0042073)2.59443179
63insulin-like growth factor receptor signaling pathway (GO:0048009)2.58753611
64Sertoli cell development (GO:0060009)2.57725278
65keratinocyte development (GO:0003334)2.57599310
66oocyte development (GO:0048599)2.57584817
67negative regulation of hormone metabolic process (GO:0032351)2.57200558
68regulation of sarcomere organization (GO:0060297)2.56950664
69smooth muscle tissue development (GO:0048745)2.54852959
70protein localization to endosome (GO:0036010)2.52730219
71double-strand break repair via homologous recombination (GO:0000724)2.51085614
72cellular ketone body metabolic process (GO:0046950)2.49527171
73cilium morphogenesis (GO:0060271)2.49092066
74regulation of protein autophosphorylation (GO:0031952)2.46940483
75regulation of pigment cell differentiation (GO:0050932)2.46904976
76phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.46627899
77rRNA catabolic process (GO:0016075)2.46481768
78recombinational repair (GO:0000725)2.44524089
79tachykinin receptor signaling pathway (GO:0007217)2.43714993
80chondrocyte development (GO:0002063)2.43637362
81cellular response to growth hormone stimulus (GO:0071378)2.42912280
82histone mRNA catabolic process (GO:0071044)2.42236476
83gland morphogenesis (GO:0022612)2.42196699
84protein localization to microtubule cytoskeleton (GO:0072698)2.42167904
85endocrine pancreas development (GO:0031018)2.41311982
86photoreceptor cell maintenance (GO:0045494)2.41210430
87histone H3-K4 trimethylation (GO:0080182)2.40493501
88positive regulation of glycolytic process (GO:0045821)2.40415372
89water-soluble vitamin biosynthetic process (GO:0042364)2.39640044
90ketone body metabolic process (GO:1902224)2.39332411
91anterior/posterior axis specification, embryo (GO:0008595)2.39234004
92regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.39096970
93regulation of transforming growth factor beta2 production (GO:0032909)2.38586426
94positive regulation of glycogen biosynthetic process (GO:0045725)2.38440641
95fibroblast migration (GO:0010761)2.38173598
96histone H3-K36 demethylation (GO:0070544)2.37265898
97righting reflex (GO:0060013)2.37255726
98reciprocal DNA recombination (GO:0035825)2.36701827
99reciprocal meiotic recombination (GO:0007131)2.36701827
100vesicle coating (GO:0006901)2.36135310
101positive regulation of muscle hypertrophy (GO:0014742)2.35973504
102positive regulation of cardiac muscle hypertrophy (GO:0010613)2.35973504
103nucleus localization (GO:0051647)2.35864545
104sequestering of metal ion (GO:0051238)2.35553481
105intestinal epithelial cell development (GO:0060576)2.33764244
106peptide hormone processing (GO:0016486)2.33452551
107* intra-Golgi vesicle-mediated transport (GO:0006891)2.33328445
108regulation of hippo signaling (GO:0035330)2.31623325
109polyol catabolic process (GO:0046174)2.31569289
110regulation of p38MAPK cascade (GO:1900744)2.30943880
111axoneme assembly (GO:0035082)2.30456704
112iron ion import (GO:0097286)2.28808664
113DNA double-strand break processing (GO:0000729)2.28601919
114positive regulation of meiosis (GO:0045836)2.27885384
115response to lipoprotein particle (GO:0055094)2.27224616
116cellular response to ethanol (GO:0071361)2.26438528
117prostate gland growth (GO:0060736)2.25903519
118columnar/cuboidal epithelial cell development (GO:0002066)2.25459498
119response to pheromone (GO:0019236)2.25446227
120positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.25122863
121regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.25122863
122detection of calcium ion (GO:0005513)2.25087841
123photoreceptor cell differentiation (GO:0046530)2.22549488
124eye photoreceptor cell differentiation (GO:0001754)2.22549488
125lipid translocation (GO:0034204)2.20458695
126phospholipid translocation (GO:0045332)2.20458695
127glandular epithelial cell development (GO:0002068)2.19159093
128regulation of establishment of cell polarity (GO:2000114)2.15536355
129negative regulation of neurotransmitter secretion (GO:0046929)2.12462743
130relaxation of cardiac muscle (GO:0055119)2.11815594
131platelet-derived growth factor receptor signaling pathway (GO:0048008)2.11461212
132activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.10785214
133maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.08530063
134glandular epithelial cell differentiation (GO:0002067)2.07987482
135embryonic camera-type eye morphogenesis (GO:0048596)2.06923953
136positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.04870678
137regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.04870678
138endoplasmic reticulum organization (GO:0007029)2.04683690
139negative regulation of glycogen biosynthetic process (GO:0045719)2.01235420
140regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.00318787
141regulation of ARF protein signal transduction (GO:0032012)1.99523717
142vascular endothelial growth factor signaling pathway (GO:0038084)1.98221875
143positive regulation of glycogen metabolic process (GO:0070875)1.98099830
144desmosome organization (GO:0002934)1.97764025
145regulation of type B pancreatic cell apoptotic process (GO:2000674)1.97207438
146* protein localization to Golgi apparatus (GO:0034067)1.96871960
147Golgi organization (GO:0007030)1.96045690
148phosphatidylinositol dephosphorylation (GO:0046856)1.95400146
149Golgi to endosome transport (GO:0006895)1.94523170
150negative regulation of bone resorption (GO:0045779)1.93511997
151early endosome to late endosome transport (GO:0045022)1.93099651
152hemidesmosome assembly (GO:0031581)1.92966692
153cellular response to vitamin D (GO:0071305)1.89913170
154phospholipid dephosphorylation (GO:0046839)1.89894662
155UDP-N-acetylglucosamine metabolic process (GO:0006047)1.89674744
156phospholipid homeostasis (GO:0055091)1.88600582
157regulation of mRNA catabolic process (GO:0061013)1.88393516
158positive regulation of nuclease activity (GO:0032075)1.88346346
159regulation of beta-amyloid formation (GO:1902003)1.87151497
160negative regulation of macrophage derived foam cell differentiation (GO:0010745)1.87093576
161regulation of branching involved in salivary gland morphogenesis (GO:0060693)1.87050915
162ER-nucleus signaling pathway (GO:0006984)1.86889953
163endoplasmic reticulum unfolded protein response (GO:0030968)1.86357867
164regulation of endothelial cell chemotaxis (GO:2001026)1.85589528
165regulation of establishment or maintenance of cell polarity (GO:0032878)1.85379451
166positive regulation of fatty acid beta-oxidation (GO:0032000)1.84855074
167peptidyl-tyrosine autophosphorylation (GO:0038083)1.84218758
168negative regulation of establishment of protein localization to plasma membrane (GO:0090005)1.82767794
169intestinal cholesterol absorption (GO:0030299)1.82722990
170cellular response to unfolded protein (GO:0034620)1.82589751
171positive regulation of bone mineralization (GO:0030501)1.82491831
172phosphatidylinositol phosphorylation (GO:0046854)1.82295228
173intracellular lipid transport (GO:0032365)1.82233697
174negative regulation of digestive system process (GO:0060457)1.82036200
175positive regulation of hormone biosynthetic process (GO:0046886)1.81957699
176hormone catabolic process (GO:0042447)1.81224740
177I-kappaB phosphorylation (GO:0007252)1.80865410
178heart morphogenesis (GO:0003007)1.80353343
179interkinetic nuclear migration (GO:0022027)1.79854438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.22197611
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31018711
3FUS_26573619_Chip-Seq_HEK293_Human2.24885624
4VDR_22108803_ChIP-Seq_LS180_Human2.24495743
5IGF1R_20145208_ChIP-Seq_DFB_Human2.22733834
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.20926590
7ZNF217_24962896_ChIP-Seq_MCF-7_Human2.20357773
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19384003
9TAF15_26573619_Chip-Seq_HEK293_Human2.10693339
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07518296
11EWS_26573619_Chip-Seq_HEK293_Human2.05711271
12ZNF274_21170338_ChIP-Seq_K562_Hela1.93999063
13PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93073245
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84729148
15ER_23166858_ChIP-Seq_MCF-7_Human1.83382912
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.81181137
17GBX2_23144817_ChIP-Seq_PC3_Human1.77890516
18GATA1_22025678_ChIP-Seq_K562_Human1.77186864
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76411127
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75930937
21TP53_16413492_ChIP-PET_HCT116_Human1.71186938
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66397327
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64983455
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.63182770
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62767257
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.59507662
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57890248
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57670103
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.57067339
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55295714
31CBP_20019798_ChIP-Seq_JUKART_Human1.55295714
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55137046
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.49869344
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.49842377
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46831051
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45571642
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45571642
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44430445
39AR_21572438_ChIP-Seq_LNCaP_Human1.43596180
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43413361
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.42692091
42AHR_22903824_ChIP-Seq_MCF-7_Human1.42481977
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39739076
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.39311360
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38279588
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.37484543
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.37186366
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37168010
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35955788
50SMAD4_21799915_ChIP-Seq_A2780_Human1.35463737
51P53_22387025_ChIP-Seq_ESCs_Mouse1.33824611
52STAT3_23295773_ChIP-Seq_U87_Human1.32631888
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32254934
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31588178
55CJUN_26792858_Chip-Seq_BT549_Human1.30468996
56TCF4_22108803_ChIP-Seq_LS180_Human1.29979481
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29471234
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29341902
59BCAT_22108803_ChIP-Seq_LS180_Human1.29299053
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25827707
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24729228
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.24077047
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.23029177
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.23028873
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22569938
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.22351078
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21943884
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21894580
69RUNX_20019798_ChIP-Seq_JUKART_Human1.21827173
70ELK1_19687146_ChIP-ChIP_HELA_Human1.21370562
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20289133
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19408049
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.19080967
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18625672
75TCF4_18268006_ChIP-ChIP_LS174T_Human1.18184719
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17010506
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16045496
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.15311830
79RUNX2_22187159_ChIP-Seq_PCA_Human1.15196248
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15127115
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.14685538
82TCF4_23295773_ChIP-Seq_U87_Human1.14230627
83DROSHA_22980978_ChIP-Seq_HELA_Human1.14174029
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14086265
85P300_18555785_Chip-Seq_ESCs_Mouse1.13730049
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13722626
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.11692942
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11047683
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.10683614
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09472995
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08933525
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08924255
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08673725
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.08380901
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.07854290
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07082536
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07003619
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06912323
99VDR_24787735_ChIP-Seq_THP-1_Human1.06827522
100P300_19829295_ChIP-Seq_ESCs_Human1.06811786
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.06775438
102TP63_23658742_ChIP-Seq_EP156T_Human1.06561612
103KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06348555
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.05834347
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.04897075
106RXR_22108803_ChIP-Seq_LS180_Human1.04419225
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.04167259
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03640674
109SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03120871
110TP53_18474530_ChIP-ChIP_U2OS_Human1.03110710
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03005629
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02317692
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02084442
114NANOG_19829295_ChIP-Seq_ESCs_Human1.02066691
115SOX2_19829295_ChIP-Seq_ESCs_Human1.02066691
116SOX2_20726797_ChIP-Seq_SW620_Human1.02040234
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.01515987
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01431293
119PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01387866
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.00647873
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99782133
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.99732503
123* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99123106
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98826700
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.98015121
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.98015121
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97804007
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97101444
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96483472
130FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96417772
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96376164
132FOXA1_25552417_ChIP-Seq_VCAP_Human0.95941651
133BRD4_25478319_ChIP-Seq_HGPS_Human0.95892269
134CDX2_22108803_ChIP-Seq_LS180_Human0.95629285
135SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95151107
136AR_25329375_ChIP-Seq_VCAP_Human0.95025278
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94803869
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94732483
139PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93921442
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.93222467
141ISL1_27105846_Chip-Seq_CPCs_Mouse0.92636377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.91431355
2MP0008057_abnormal_DNA_replication3.84678578
3MP0002877_abnormal_melanocyte_morpholog3.57029535
4MP0000569_abnormal_digit_pigmentation3.42953939
5MP0003300_gastrointestinal_ulcer3.29729250
6MP0003045_fibrosis3.18845937
7MP0008438_abnormal_cutaneous_collagen2.35333230
8MP0001299_abnormal_eye_distance/2.29564762
9MP0000013_abnormal_adipose_tissue2.28839910
10MP0003252_abnormal_bile_duct2.18026424
11MP0002009_preneoplasia2.17787458
12MP0003890_abnormal_embryonic-extraembry2.16307948
13MP0000003_abnormal_adipose_tissue2.05616113
14MP0002837_dystrophic_cardiac_calcinosis1.99725449
15MP0003868_abnormal_feces_composition1.98797939
16MP0002693_abnormal_pancreas_physiology1.89633031
17MP0004264_abnormal_extraembryonic_tissu1.88016304
18MP0006072_abnormal_retinal_apoptosis1.81995782
19MP0009384_cardiac_valve_regurgitation1.81657829
20MP0002909_abnormal_adrenal_gland1.80342232
21MP0004043_abnormal_pH_regulation1.78559977
22MP0002166_altered_tumor_susceptibility1.76385018
23MP0001944_abnormal_pancreas_morphology1.71419234
24MP0005275_abnormal_skin_tensile1.69879925
25MP0005220_abnormal_exocrine_pancreas1.67897683
26MP0005379_endocrine/exocrine_gland_phen1.66457940
27MP0005375_adipose_tissue_phenotype1.64687587
28* MP0002896_abnormal_bone_mineralization1.63541344
29* MP0009780_abnormal_chondrocyte_physiolo1.63029749
30MP0005503_abnormal_tendon_morphology1.62020267
31MP0002102_abnormal_ear_morphology1.59532547
32MP0005174_abnormal_tail_pigmentation1.59405471
33MP0000383_abnormal_hair_follicle1.56307828
34MP0003941_abnormal_skin_development1.55726556
35MP0005666_abnormal_adipose_tissue1.55156156
36MP0001666_abnormal_nutrient_absorption1.55068164
37MP0002876_abnormal_thyroid_physiology1.48882795
38MP0010678_abnormal_skin_adnexa1.48716730
39MP0005365_abnormal_bile_salt1.44609749
40MP0005367_renal/urinary_system_phenotyp1.42717013
41MP0000516_abnormal_urinary_system1.42717013
42MP0002933_joint_inflammation1.42572679
43MP0001661_extended_life_span1.41464692
44MP0000462_abnormal_digestive_system1.40536265
45MP0005551_abnormal_eye_electrophysiolog1.40348456
46MP0008961_abnormal_basal_metabolism1.38753539
47MP0004084_abnormal_cardiac_muscle1.37292021
48MP0004272_abnormal_basement_membrane1.37261578
49MP0002168_other_aberrant_phenotype1.37163158
50MP0000427_abnormal_hair_cycle1.36301140
51MP0003121_genomic_imprinting1.35975689
52MP0005253_abnormal_eye_physiology1.32298946
53MP0003950_abnormal_plasma_membrane1.32133683
54MP0003091_abnormal_cell_migration1.30614065
55MP0010368_abnormal_lymphatic_system1.29912501
56MP0005670_abnormal_white_adipose1.28761124
57MP0002928_abnormal_bile_duct1.27850475
58MP0003705_abnormal_hypodermis_morpholog1.27634048
59* MP0003183_abnormal_peptide_metabolism1.27527984
60MP0002060_abnormal_skin_morphology1.24366409
61MP0005076_abnormal_cell_differentiation1.23152296
62MP0002006_tumorigenesis1.22493186
63MP0005395_other_phenotype1.19301943
64MP0001879_abnormal_lymphatic_vessel1.18564456
65MP0004036_abnormal_muscle_relaxation1.17575588
66MP0004130_abnormal_muscle_cell1.17385897
67MP0003195_calcinosis1.14840730
68MP0004134_abnormal_chest_morphology1.14532399
69MP0004185_abnormal_adipocyte_glucose1.14041303
70MP0002108_abnormal_muscle_morphology1.13006963
71MP0005058_abnormal_lysosome_morphology1.12163394
72MP0002078_abnormal_glucose_homeostasis1.11241682
73MP0001270_distended_abdomen1.10257904
74MP0003011_delayed_dark_adaptation1.09018478
75MP0003937_abnormal_limbs/digits/tail_de1.07215258
76MP0005257_abnormal_intraocular_pressure1.06628403
77MP0003787_abnormal_imprinting1.06343561
78MP0002998_abnormal_bone_remodeling1.05611613
79MP0002139_abnormal_hepatobiliary_system1.05109259
80MP0000371_diluted_coat_color1.04398490
81MP0005310_abnormal_salivary_gland1.04343610
82MP0010386_abnormal_urinary_bladder1.03556178
83MP0002254_reproductive_system_inflammat1.02785237
84MP0001756_abnormal_urination1.02603526
85MP0003172_abnormal_lysosome_physiology1.02478033
86MP0000647_abnormal_sebaceous_gland0.99654401
87MP0003279_aneurysm0.99287719
88MP0003566_abnormal_cell_adhesion0.99277068
89MP0010307_abnormal_tumor_latency0.99139757
90MP0001765_abnormal_ion_homeostasis0.98900619
91MP0000015_abnormal_ear_pigmentation0.98523991
92MP0001485_abnormal_pinna_reflex0.94513483
93MP0006054_spinal_hemorrhage0.94030133
94MP0000538_abnormal_urinary_bladder0.93223054
95MP0003718_maternal_effect0.93101337
96MP0002138_abnormal_hepatobiliary_system0.91548285
97MP0000920_abnormal_myelination0.90799138
98MP0003646_muscle_fatigue0.90516158
99MP0005408_hypopigmentation0.90223900
100MP0002295_abnormal_pulmonary_circulatio0.90192108
101MP0002234_abnormal_pharynx_morphology0.90009799
102MP0005334_abnormal_fat_pad0.89825318
103MP0003690_abnormal_glial_cell0.89755739
104MP0010234_abnormal_vibrissa_follicle0.88930730
105MP0009697_abnormal_copulation0.88387144
106MP0002233_abnormal_nose_morphology0.87728572
107MP0001873_stomach_inflammation0.87496574
108* MP0003795_abnormal_bone_structure0.86356479
109MP0001984_abnormal_olfaction0.85262235
110MP0002118_abnormal_lipid_homeostasis0.84973856
111MP0004510_myositis0.84572595
112MP0008058_abnormal_DNA_repair0.84196280
113MP0004145_abnormal_muscle_electrophysio0.83183987
114MP0005248_abnormal_Harderian_gland0.81450591
115MP0005085_abnormal_gallbladder_physiolo0.80619536
116MP0005187_abnormal_penis_morphology0.77958795
117MP0005075_abnormal_melanosome_morpholog0.77778045
118MP0000372_irregular_coat_pigmentation0.77515173
119MP0010352_gastrointestinal_tract_polyps0.77371033
120MP0004215_abnormal_myocardial_fiber0.76926226
121MP0002938_white_spotting0.76850036
122MP0001191_abnormal_skin_condition0.76733773
123MP0001958_emphysema0.76691627
124MP0002098_abnormal_vibrissa_morphology0.76368988
125MP0002972_abnormal_cardiac_muscle0.76110396
126MP0004885_abnormal_endolymph0.75694064
127MP0003936_abnormal_reproductive_system0.75581876
128* MP0000163_abnormal_cartilage_morphology0.75578284
129MP0004484_altered_response_of0.75285665
130MP0010630_abnormal_cardiac_muscle0.74697056
131MP0003828_pulmonary_edema0.74445163
132MP0001929_abnormal_gametogenesis0.74332339
133MP0003755_abnormal_palate_morphology0.74323614
134MP0008775_abnormal_heart_ventricle0.73522127
135MP0004085_abnormal_heartbeat0.73451227
136MP0005448_abnormal_energy_balance0.73026100
137MP0002971_abnormal_brown_adipose0.72878935
138* MP0002115_abnormal_skeleton_extremities0.72075287
139MP0000579_abnormal_nail_morphology0.71564930
140MP0001346_abnormal_lacrimal_gland0.71554723
141MP0005508_abnormal_skeleton_morphology0.71004558
142MP0003786_premature_aging0.70231114
143MP0002160_abnormal_reproductive_system0.69484690
144MP0005084_abnormal_gallbladder_morpholo0.69015997
145MP0005389_reproductive_system_phenotype0.68754697
146MP0002177_abnormal_outer_ear0.67904638
147MP0000377_abnormal_hair_follicle0.67827606
148* MP0002109_abnormal_limb_morphology0.67707905
149MP0002095_abnormal_skin_pigmentation0.67479293
150MP0000653_abnormal_sex_gland0.65569372
151MP0003935_abnormal_craniofacial_develop0.65045442
152MP0002638_abnormal_pupillary_reflex0.64883497
153MP0002127_abnormal_cardiovascular_syste0.64429620
154MP0003943_abnormal_hepatobiliary_system0.64222298
155MP0002084_abnormal_developmental_patter0.63173525
156MP0002090_abnormal_vision0.62754425

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)3.70315998
2Hyperinsulinemic hypoglycemia (HP:0000825)3.69696875
3Hyperglycemia (HP:0003074)3.46232094
4Insulin-resistant diabetes mellitus (HP:0000831)3.45032994
5Fair hair (HP:0002286)3.36526893
6Symptomatic seizures (HP:0011145)3.18948958
7* Abnormality of the ischium (HP:0003174)3.09366095
8* Hypoplastic ischia (HP:0003175)3.08758621
9Tubulointerstitial nephritis (HP:0001970)3.05914192
10Thyroid carcinoma (HP:0002890)3.05029973
11Hypoglycemic coma (HP:0001325)3.04606401
12Hyperventilation (HP:0002883)3.02889069
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.91838687
14Macroorchidism (HP:0000053)2.90500245
15Pancreatic cysts (HP:0001737)2.77998638
16Abnormality of the fingertips (HP:0001211)2.73685756
17Abnormality of the renal medulla (HP:0100957)2.69966405
18Metaphyseal dysplasia (HP:0100255)2.69941761
19Medial flaring of the eyebrow (HP:0010747)2.69855891
20Generalized hypopigmentation of hair (HP:0011358)2.67968080
21Nephronophthisis (HP:0000090)2.67707582
22Conjugated hyperbilirubinemia (HP:0002908)2.67422273
23Calf muscle hypertrophy (HP:0008981)2.63579735
24Gaze-evoked nystagmus (HP:0000640)2.61649069
25Abnormality of the nasal septum (HP:0000419)2.58901910
26Bell-shaped thorax (HP:0001591)2.55407557
27Epiphyseal dysplasia (HP:0002656)2.54648553
28Molar tooth sign on MRI (HP:0002419)2.54481684
29Abnormality of midbrain morphology (HP:0002418)2.54481684
30Aortic aneurysm (HP:0004942)2.51534570
31Hyperkalemia (HP:0002153)2.51403123
32Abnormal biliary tract morphology (HP:0012440)2.49043805
33Widely spaced teeth (HP:0000687)2.45530055
34Hypoplastic labia majora (HP:0000059)2.44855336
35Intestinal atresia (HP:0011100)2.40716104
36Pancreatic fibrosis (HP:0100732)2.39125865
37Hyporeflexia of lower limbs (HP:0002600)2.38740177
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.37096828
39Thyroiditis (HP:0100646)2.36333650
40Spondylolisthesis (HP:0003302)2.33740736
41Abnormality of chromosome stability (HP:0003220)2.32205964
42Chromsome breakage (HP:0040012)2.31216112
43Lip pit (HP:0100267)2.28792853
44Volvulus (HP:0002580)2.28724598
45True hermaphroditism (HP:0010459)2.28287462
46Right ventricular cardiomyopathy (HP:0011663)2.27017932
47Biliary tract neoplasm (HP:0100574)2.22072224
48Rhabdomyosarcoma (HP:0002859)2.22023710
49Chronic diarrhea (HP:0002028)2.19475818
50Muscle hypertrophy of the lower extremities (HP:0008968)2.18961635
51Pancreatic islet-cell hyperplasia (HP:0004510)2.17474246
52Narrow palate (HP:0000189)2.17015228
53Atrophic scars (HP:0001075)2.16705355
54Abnormality of the labia majora (HP:0012881)2.16362757
55Hematochezia (HP:0002573)2.14858400
56Tubular atrophy (HP:0000092)2.11408721
57Abnormality of the astrocytes (HP:0100707)2.10957719
58Astrocytoma (HP:0009592)2.10957719
59Hypothermia (HP:0002045)2.10803645
60Abnormality of the right ventricle (HP:0001707)2.08660300
61Increased number of teeth (HP:0011069)2.08637909
62Cerebral aneurysm (HP:0004944)2.08389028
63Abnormality of the intrinsic pathway (HP:0010989)2.07685175
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.06639617
65Glioma (HP:0009733)2.06241288
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.06205429
67Abnormality of the common coagulation pathway (HP:0010990)2.06087393
68Abnormality of incisor morphology (HP:0011063)2.05561055
69Curly hair (HP:0002212)2.03127980
70Congenital primary aphakia (HP:0007707)2.03083573
71Papillary thyroid carcinoma (HP:0002895)2.00044430
72Urethral obstruction (HP:0000796)1.98870079
73Methylmalonic acidemia (HP:0002912)1.97637457
74Ependymoma (HP:0002888)1.95832727
75Protruding tongue (HP:0010808)1.94700391
76Slow saccadic eye movements (HP:0000514)1.92330248
77Thoracolumbar scoliosis (HP:0002944)1.92115623
78Genetic anticipation (HP:0003743)1.91653236
79Gait imbalance (HP:0002141)1.91115393
80Gonadotropin excess (HP:0000837)1.90504983
81Absent frontal sinuses (HP:0002688)1.89153868
82Genital tract atresia (HP:0001827)1.88780415
83Exostoses (HP:0100777)1.88222247
84Furrowed tongue (HP:0000221)1.87816045
85Decreased circulating renin level (HP:0003351)1.87208087
86Abnormality of calcium-phosphate metabolism (HP:0100530)1.86301242
87Poor coordination (HP:0002370)1.85875170
88* Abdominal distention (HP:0003270)1.85394761
89Abnormal hair whorl (HP:0010721)1.85300772
90Aneurysm (HP:0002617)1.85150216
91Medulloblastoma (HP:0002885)1.85099424
92Hip dysplasia (HP:0001385)1.83976936
93Renal cortical cysts (HP:0000803)1.83777667
94Facial diplegia (HP:0001349)1.82010186
95Chronic hepatic failure (HP:0100626)1.81468359
96Vitreoretinal degeneration (HP:0000655)1.81273316
97Hamartoma of the eye (HP:0010568)1.81161357
98Abnormality of vitamin B metabolism (HP:0004340)1.80995754
99Neoplasm of the adrenal cortex (HP:0100641)1.80663025
100Abnormality of potassium homeostasis (HP:0011042)1.80527210
101Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.80221318
102Hypoplastic iliac wings (HP:0002866)1.79308395
103Truncal obesity (HP:0001956)1.79299643
104Abnormal pancreas size (HP:0012094)1.78724277
105Drooling (HP:0002307)1.78600170
106Aplasia cutis congenita (HP:0001057)1.77833192
107Hypoplasia of the iris (HP:0007676)1.77016786
108Nephrogenic diabetes insipidus (HP:0009806)1.76804373
109Submucous cleft hard palate (HP:0000176)1.76086173
110Abnormality of endocrine pancreas physiology (HP:0012093)1.75716417
111Abnormality of the pancreatic islet cells (HP:0006476)1.75716417
112Enlarged epiphyses (HP:0010580)1.75556045
113Aortic dissection (HP:0002647)1.73159745
114Ketoacidosis (HP:0001993)1.72903915
115Arterial tortuosity (HP:0005116)1.72834704
116Myocardial infarction (HP:0001658)1.71602687
117Acute myeloid leukemia (HP:0004808)1.70767402
118Flat capital femoral epiphysis (HP:0003370)1.70746865
119Vaginal atresia (HP:0000148)1.70603554
120Breast carcinoma (HP:0003002)1.70102786
121Albinism (HP:0001022)1.69450791
122Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69066483
123Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.69042255
124Hypoplasia of dental enamel (HP:0006297)1.69020110
125White forelock (HP:0002211)1.68680525
126Astigmatism (HP:0000483)1.67988383
127Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67833507
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67833507
129Abnormality of polysaccharide metabolism (HP:0011012)1.67833507
130Buphthalmos (HP:0000557)1.66935945
131Proximal tubulopathy (HP:0000114)1.66896160
132Cupped ribs (HP:0000887)1.65967153
133Abnormality of the frontal sinuses (HP:0002687)1.65859605
134Retinal atrophy (HP:0001105)1.65620304
135Mitral valve prolapse (HP:0001634)1.64829523
136Neoplasm of striated muscle (HP:0009728)1.64514643
137Overgrowth (HP:0001548)1.63810309
138Limited elbow extension (HP:0001377)1.62937048
139Short metatarsal (HP:0010743)1.62724212
140Urinary glycosaminoglycan excretion (HP:0003541)1.62687013
141Mucopolysacchariduria (HP:0008155)1.62687013
142Mitral stenosis (HP:0001718)1.62128780
143Neoplasm of the thyroid gland (HP:0100031)1.61731112
144Short foot (HP:0001773)1.61613698
145Broad metatarsal (HP:0001783)1.61602176
146Downturned corners of mouth (HP:0002714)1.61390247
147* Protuberant abdomen (HP:0001538)1.60756425
148Double outlet right ventricle (HP:0001719)1.60730688
149Congenital malformation of the right heart (HP:0011723)1.60730688
150Glucose intolerance (HP:0000833)1.59928811
151Postaxial foot polydactyly (HP:0001830)1.59922350
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.59275614
153Absent/shortened dynein arms (HP:0200106)1.59275614
154Tented upper lip vermilion (HP:0010804)1.59198041
155Aplasia/Hypoplasia of the uvula (HP:0010293)1.58180542
156Cupped ear (HP:0000378)1.57188816
157Abnormality of the renal cortex (HP:0011035)1.56882708
158Craniofacial hyperostosis (HP:0004493)1.55357182
159Cranial hyperostosis (HP:0004437)1.55100522
160Long clavicles (HP:0000890)1.54988552
161Abnormality of the metopic suture (HP:0005556)1.54837600
162Hypomagnesemia (HP:0002917)1.54381891
163Tubulointerstitial abnormality (HP:0001969)1.54072734
164Vascular tortuosity (HP:0004948)1.53541143
165Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.53427797
166Deep philtrum (HP:0002002)1.53119970
167Limited hip movement (HP:0008800)1.52687037
168Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.52587062
169Degeneration of the lateral corticospinal tracts (HP:0002314)1.52587062
170Prolonged QT interval (HP:0001657)1.52396448
171Hypoproteinemia (HP:0003075)1.52371573
172Dysostosis multiplex (HP:0000943)1.52115071
173Hypokalemia (HP:0002900)1.51905530
174Oligodactyly (hands) (HP:0001180)1.51885849
175Absent speech (HP:0001344)1.51581263
176Long eyelashes (HP:0000527)1.51257280
177Osteoarthritis (HP:0002758)1.50330430
178Mildly elevated creatine phosphokinase (HP:0008180)1.50070850
179Congenital sensorineural hearing impairment (HP:0008527)1.49910943
180Coarse hair (HP:0002208)1.49138155
181Thick nail (HP:0001805)1.48268097
182Skin nodule (HP:0200036)1.47192666
183Premature skin wrinkling (HP:0100678)1.47050510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.27375878
2FRK3.55616345
3LATS12.93907063
4TAOK32.91747363
5ACVR1B2.85772526
6NUAK12.66742289
7MAP4K22.36284632
8CAMK1G2.35353181
9PIK3CA2.26298084
10CAMK1D2.25861461
11TNIK2.21503192
12PNCK2.14536075
13EIF2AK32.03644046
14PIK3CG1.97679797
15STK38L1.96050077
16ERBB31.92887304
17SIK11.79446767
18DMPK1.67939390
19MAP3K21.65052478
20WNK11.60750443
21JAK11.58776816
22FGFR21.58396711
23MAPK151.53656809
24MAP3K121.47579991
25EPHB11.43275669
26CASK1.41298293
27FGFR31.39951678
28CDK121.39582332
29EPHA31.34063395
30RIPK11.32554102
31WNK41.32039248
32GRK11.30767284
33MAP3K41.30444979
34BRSK21.28569701
35STK391.26845529
36HIPK21.26822918
37ITK1.26701677
38PRKD31.25257272
39PDGFRB1.24231390
40MAP3K141.23860933
41PTK61.21600496
42TAF11.20188911
43TTN1.18987011
44EIF2AK11.18061515
45PLK21.17848327
46AKT31.15694906
47TRPM71.15647696
48CDC42BPA1.14001867
49OXSR11.12916022
50SGK31.11894716
51NEK61.11038878
52TEC1.10740773
53STK31.10298104
54TRIM281.10259579
55PRKCH1.08737244
56MAP3K31.05613029
57CDK81.02718869
58SGK21.00406186
59BRD40.99358105
60PRKAA20.96413164
61ZAK0.95741710
62MKNK20.95376125
63LMTK20.91884812
64DDR20.91205871
65TGFBR20.90519276
66NEK90.89450544
67PRKD10.88868788
68STK240.88635394
69PINK10.84508029
70PAK30.84308503
71MELK0.82756983
72ADRBK20.82597425
73RET0.80762732
74MYLK0.80718288
75PTK20.80440278
76MAPK130.80236295
77PLK40.80008792
78NLK0.79670781
79FGFR40.79569710
80TGFBR10.78451249
81FER0.78220432
82CHUK0.77824171
83OBSCN0.77535969
84MAP3K70.77048168
85PRKCQ0.74919954
86TIE10.74591859
87MTOR0.71968906
88PDGFRA0.71665005
89ERN10.71599870
90MET0.69980334
91SGK4940.69454402
92SGK2230.69454402
93MAP3K60.68694520
94PKN10.68081411
95TYK20.68014674
96CSK0.66909456
97MAP3K130.66733670
98PRKAA10.64512556
99PRKCE0.64145314
100PTK2B0.63857805
101ATM0.63132527
102IRAK30.62522478
103IGF1R0.61817479
104PHKG10.61112206
105PHKG20.61112206
106CAMKK20.61104711
107PRKD20.60313831
108MARK20.59285766
109CDK90.57327131
110SGK10.57249497
111MAP3K90.57146513
112CDK30.56839459
113MST40.56290144
114BCR0.55558747
115GSK3A0.55376347
116PBK0.55131844
117TRIB30.54899593
118FGFR10.53925542
119INSR0.53894670
120STK100.53696982
121JAK30.53386953
122JAK20.53331188
123PLK30.52451861
124IRAK10.51681641
125NTRK30.50411862
126PDK10.49542743
127PDPK10.48895855
128TXK0.48217549
129ERBB40.43784098
130ADRBK10.43218350
131MAPK70.41716301
132SCYL20.40648273
133PRKACB0.40057535
134WNK30.39651486
135ROCK10.39622774
136YES10.39488149
137BMPR1B0.38807248
138CAMK2D0.38498971
139FYN0.37756694
140MST1R0.37566989
141CSNK1G10.37187703
142PRKG10.36237495
143CSNK1D0.34934358
144EIF2AK20.34762862
145BMPR20.30852819
146MUSK0.29252557
147ABL10.29050313

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.36775041
2Non-homologous end-joining_Homo sapiens_hsa034503.06533737
3Basal transcription factors_Homo sapiens_hsa030222.55227034
4Propanoate metabolism_Homo sapiens_hsa006402.14586041
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06209456
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05715848
7Type II diabetes mellitus_Homo sapiens_hsa049302.03511322
8Butanoate metabolism_Homo sapiens_hsa006501.90430071
9Homologous recombination_Homo sapiens_hsa034401.89473042
10Fanconi anemia pathway_Homo sapiens_hsa034601.87462252
11Sulfur metabolism_Homo sapiens_hsa009201.83788714
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68166878
13TGF-beta signaling pathway_Homo sapiens_hsa043501.54440562
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53729366
15Lysine degradation_Homo sapiens_hsa003101.51283188
16Insulin secretion_Homo sapiens_hsa049111.51164707
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48572191
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.46015778
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.43709406
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42787812
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39833541
22Phototransduction_Homo sapiens_hsa047441.36908960
23Regulation of autophagy_Homo sapiens_hsa041401.36111475
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.35605356
25ECM-receptor interaction_Homo sapiens_hsa045121.34835199
26Insulin resistance_Homo sapiens_hsa049311.31867175
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.31542599
28Nucleotide excision repair_Homo sapiens_hsa034201.27433972
29RNA degradation_Homo sapiens_hsa030181.24627768
30ABC transporters_Homo sapiens_hsa020101.20259314
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19644077
32Dorso-ventral axis formation_Homo sapiens_hsa043201.19393412
33Protein digestion and absorption_Homo sapiens_hsa049741.19119780
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15190755
35Ether lipid metabolism_Homo sapiens_hsa005651.13076795
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12641909
37Sphingolipid metabolism_Homo sapiens_hsa006001.11555595
38Adherens junction_Homo sapiens_hsa045201.10995334
39Retinol metabolism_Homo sapiens_hsa008301.10928492
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10214355
41Focal adhesion_Homo sapiens_hsa045101.09678536
42Pancreatic secretion_Homo sapiens_hsa049721.08561209
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05720028
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04213488
45Dilated cardiomyopathy_Homo sapiens_hsa054141.04057244
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02351640
47Peroxisome_Homo sapiens_hsa041461.01314530
48Prostate cancer_Homo sapiens_hsa052151.00183512
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00113273
50Selenocompound metabolism_Homo sapiens_hsa004501.00087497
51Chemical carcinogenesis_Homo sapiens_hsa052040.96618745
52Tight junction_Homo sapiens_hsa045300.96581750
53Caffeine metabolism_Homo sapiens_hsa002320.94744862
54Circadian rhythm_Homo sapiens_hsa047100.93124126
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91322317
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91200090
57Starch and sucrose metabolism_Homo sapiens_hsa005000.91050962
58Renin secretion_Homo sapiens_hsa049240.91024154
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90955988
60Protein export_Homo sapiens_hsa030600.90291982
61Nitrogen metabolism_Homo sapiens_hsa009100.88559354
62beta-Alanine metabolism_Homo sapiens_hsa004100.87497527
63Lysosome_Homo sapiens_hsa041420.86732021
64Mineral absorption_Homo sapiens_hsa049780.85751475
65Inositol phosphate metabolism_Homo sapiens_hsa005620.85556191
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.85148788
67Fat digestion and absorption_Homo sapiens_hsa049750.81827799
68Osteoclast differentiation_Homo sapiens_hsa043800.81270534
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80256389
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78821436
71Platelet activation_Homo sapiens_hsa046110.76716644
72Amoebiasis_Homo sapiens_hsa051460.76478971
73Thyroid hormone synthesis_Homo sapiens_hsa049180.76424520
74Prolactin signaling pathway_Homo sapiens_hsa049170.73659319
75Glucagon signaling pathway_Homo sapiens_hsa049220.73592413
76Proteoglycans in cancer_Homo sapiens_hsa052050.73540772
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72826567
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71895818
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71725145
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.71280134
81Pancreatic cancer_Homo sapiens_hsa052120.71235848
82Renin-angiotensin system_Homo sapiens_hsa046140.71192091
83Salivary secretion_Homo sapiens_hsa049700.70787453
84cAMP signaling pathway_Homo sapiens_hsa040240.69374772
85Toxoplasmosis_Homo sapiens_hsa051450.69232588
86mTOR signaling pathway_Homo sapiens_hsa041500.68957566
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68856994
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.68804235
89Tryptophan metabolism_Homo sapiens_hsa003800.68258008
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67565970
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67431937
92Taste transduction_Homo sapiens_hsa047420.66740948
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66533158
94Renal cell carcinoma_Homo sapiens_hsa052110.66360806
95FoxO signaling pathway_Homo sapiens_hsa040680.66301775
96Ovarian steroidogenesis_Homo sapiens_hsa049130.64659631
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64278028
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.62391039
99AMPK signaling pathway_Homo sapiens_hsa041520.62315870
100Steroid biosynthesis_Homo sapiens_hsa001000.62024485
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61811018
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61731216
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.61134601
104PPAR signaling pathway_Homo sapiens_hsa033200.61028717
105Cocaine addiction_Homo sapiens_hsa050300.60978778
106Mismatch repair_Homo sapiens_hsa034300.59804619
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.59802502
108p53 signaling pathway_Homo sapiens_hsa041150.59493409
109Serotonergic synapse_Homo sapiens_hsa047260.59101463
110Insulin signaling pathway_Homo sapiens_hsa049100.57375864
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57288298
112Fatty acid degradation_Homo sapiens_hsa000710.57279905
113Glycerolipid metabolism_Homo sapiens_hsa005610.57180175
114Estrogen signaling pathway_Homo sapiens_hsa049150.55451367
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55115065
116Oocyte meiosis_Homo sapiens_hsa041140.54856672
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54724203
118Fatty acid biosynthesis_Homo sapiens_hsa000610.52951785
119T cell receptor signaling pathway_Homo sapiens_hsa046600.52727571
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52578344
121TNF signaling pathway_Homo sapiens_hsa046680.51552627
122Hippo signaling pathway_Homo sapiens_hsa043900.51108868
123Wnt signaling pathway_Homo sapiens_hsa043100.50901189
124Linoleic acid metabolism_Homo sapiens_hsa005910.50890373
125Other glycan degradation_Homo sapiens_hsa005110.50713379
126Endometrial cancer_Homo sapiens_hsa052130.50449548
127Cholinergic synapse_Homo sapiens_hsa047250.50390906
128Small cell lung cancer_Homo sapiens_hsa052220.50277607
129Choline metabolism in cancer_Homo sapiens_hsa052310.49672821
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49554918
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49529737
132B cell receptor signaling pathway_Homo sapiens_hsa046620.49217455
133RNA transport_Homo sapiens_hsa030130.49186710
134Ras signaling pathway_Homo sapiens_hsa040140.48852851
135Fatty acid metabolism_Homo sapiens_hsa012120.47974896
136Staphylococcus aureus infection_Homo sapiens_hsa051500.47098165
137Fatty acid elongation_Homo sapiens_hsa000620.46823121
138Long-term depression_Homo sapiens_hsa047300.46806895
139Hepatitis C_Homo sapiens_hsa051600.46232768
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45266917
141Complement and coagulation cascades_Homo sapiens_hsa046100.45176108
142Bile secretion_Homo sapiens_hsa049760.44773499
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44541665
144MicroRNAs in cancer_Homo sapiens_hsa052060.44264379
145Gastric acid secretion_Homo sapiens_hsa049710.44006249
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.43988747
147Vibrio cholerae infection_Homo sapiens_hsa051100.43644306
148Melanoma_Homo sapiens_hsa052180.43601276
149Chronic myeloid leukemia_Homo sapiens_hsa052200.43370836
150Collecting duct acid secretion_Homo sapiens_hsa049660.43245567
151Malaria_Homo sapiens_hsa051440.42930662
152Rap1 signaling pathway_Homo sapiens_hsa040150.42623816
153Histidine metabolism_Homo sapiens_hsa003400.42199610
154Arachidonic acid metabolism_Homo sapiens_hsa005900.41723105
155Calcium signaling pathway_Homo sapiens_hsa040200.37789284

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