TRIP13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.04692525
2mitotic metaphase plate congression (GO:0007080)4.99604409
3DNA replication checkpoint (GO:0000076)4.75452492
4DNA strand elongation involved in DNA replication (GO:0006271)4.71798780
5nucleobase biosynthetic process (GO:0046112)4.69775188
6purine nucleobase biosynthetic process (GO:0009113)4.64830058
7DNA replication initiation (GO:0006270)4.59418164
8DNA strand elongation (GO:0022616)4.48493654
9DNA unwinding involved in DNA replication (GO:0006268)4.40401040
10telomere maintenance via semi-conservative replication (GO:0032201)4.35108335
11protein localization to chromosome, centromeric region (GO:0071459)4.33801525
12regulation of spindle organization (GO:0090224)4.33258287
13mitotic nuclear envelope disassembly (GO:0007077)4.33136762
14CENP-A containing nucleosome assembly (GO:0034080)4.32820985
15metaphase plate congression (GO:0051310)4.32526811
16chromatin remodeling at centromere (GO:0031055)4.28422814
17establishment of integrated proviral latency (GO:0075713)4.22958066
18ribosome assembly (GO:0042255)4.22512249
19nuclear pore organization (GO:0006999)4.22270693
20formation of translation preinitiation complex (GO:0001731)4.14160114
21kinetochore organization (GO:0051383)4.13379438
22DNA replication-dependent nucleosome organization (GO:0034723)4.13161057
23DNA replication-dependent nucleosome assembly (GO:0006335)4.13161057
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.10731407
25attachment of spindle microtubules to kinetochore (GO:0008608)4.05130461
26membrane disassembly (GO:0030397)4.01648823
27nuclear envelope disassembly (GO:0051081)4.01648823
28mitotic sister chromatid cohesion (GO:0007064)4.01103899
29mitotic sister chromatid segregation (GO:0000070)4.00332714
30maturation of SSU-rRNA (GO:0030490)4.00174154
31DNA replication-independent nucleosome organization (GO:0034724)3.98622702
32DNA replication-independent nucleosome assembly (GO:0006336)3.98622702
33telomere maintenance via recombination (GO:0000722)3.97548379
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.95379839
35mitotic recombination (GO:0006312)3.91939940
36nuclear pore complex assembly (GO:0051292)3.88474391
37establishment of chromosome localization (GO:0051303)3.84071813
38ribosome biogenesis (GO:0042254)3.82329428
39mitotic chromosome condensation (GO:0007076)3.81353082
40kinetochore assembly (GO:0051382)3.79549937
41histone exchange (GO:0043486)3.70898720
42IMP biosynthetic process (GO:0006188)3.70110712
43sister chromatid segregation (GO:0000819)3.67028530
44spindle checkpoint (GO:0031577)3.66728612
45chromosome condensation (GO:0030261)3.65681704
46positive regulation of chromosome segregation (GO:0051984)3.64981315
47regulation of mitotic spindle organization (GO:0060236)3.62026585
48telomere maintenance via telomere lengthening (GO:0010833)3.60732210
49negative regulation of chromosome segregation (GO:0051985)3.52387077
50folic acid-containing compound biosynthetic process (GO:0009396)3.51779933
51regulation of chromosome segregation (GO:0051983)3.50443522
52nucleobase-containing small molecule interconversion (GO:0015949)3.49547231
53ribosomal large subunit biogenesis (GO:0042273)3.49222568
54spindle assembly checkpoint (GO:0071173)3.49057062
55ribonucleoprotein complex biogenesis (GO:0022613)3.48838030
56negative regulation of mitotic sister chromatid separation (GO:2000816)3.48484403
57negative regulation of mitotic sister chromatid segregation (GO:0033048)3.48484403
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.48484403
59negative regulation of sister chromatid segregation (GO:0033046)3.48484403
60regulation of translational fidelity (GO:0006450)3.45030186
61mitotic spindle assembly checkpoint (GO:0007094)3.44312830
62mitotic spindle checkpoint (GO:0071174)3.43752069
63regulation of mitotic metaphase/anaphase transition (GO:0030071)3.43293911
64DNA packaging (GO:0006323)3.39791704
65DNA synthesis involved in DNA repair (GO:0000731)3.38634707
66regulation of mitochondrial translation (GO:0070129)3.38460978
67negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.37792330
68regulation of double-strand break repair via homologous recombination (GO:0010569)3.37501202
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.37130322
70spliceosomal snRNP assembly (GO:0000387)3.36926294
71protein complex localization (GO:0031503)3.35687672
72meiotic chromosome segregation (GO:0045132)3.35262613
73regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.35149820
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35064867
75regulation of centriole replication (GO:0046599)3.32395787
76protein localization to chromosome (GO:0034502)3.30478569
77rRNA processing (GO:0006364)3.29003077
78regulation of centrosome cycle (GO:0046605)3.27476305
79IMP metabolic process (GO:0046040)3.25928915
80folic acid metabolic process (GO:0046655)3.25776672
81DNA deamination (GO:0045006)3.24947543
82double-strand break repair via nonhomologous end joining (GO:0006303)3.22364010
83non-recombinational repair (GO:0000726)3.22364010
84DNA ligation (GO:0006266)3.21846028
85histone-serine phosphorylation (GO:0035404)3.21383929
86establishment of viral latency (GO:0019043)3.20895488
87regulation of mitotic sister chromatid separation (GO:0010965)3.20663172
88regulation of mitotic sister chromatid segregation (GO:0033047)3.20663172
89regulation of sister chromatid segregation (GO:0033045)3.20663172
90nuclear envelope organization (GO:0006998)3.18984253
91rRNA metabolic process (GO:0016072)3.18698184
92chromatin assembly or disassembly (GO:0006333)3.17117851
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17088517
94protein K6-linked ubiquitination (GO:0085020)3.15947966
95chromosome segregation (GO:0007059)3.14905951
96regulation of nuclear cell cycle DNA replication (GO:0033262)3.12942143
97proteasome assembly (GO:0043248)3.12098426
98DNA topological change (GO:0006265)3.09944549
99pore complex assembly (GO:0046931)3.09345662
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08873901
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08135356
102cell cycle G1/S phase transition (GO:0044843)3.07295722
103G1/S transition of mitotic cell cycle (GO:0000082)3.07295722
104cellular protein complex localization (GO:0034629)3.05243338
105DNA conformation change (GO:0071103)3.04454311
106DNA geometric change (GO:0032392)3.04453806
107DNA duplex unwinding (GO:0032508)3.04360779
108transcription-coupled nucleotide-excision repair (GO:0006283)3.03449988
109ATP-dependent chromatin remodeling (GO:0043044)3.00343423
110rRNA modification (GO:0000154)3.00225923
111regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99361001
112ribosomal small subunit biogenesis (GO:0042274)2.99163576
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98855468
114negative regulation of ligase activity (GO:0051352)2.98855468
115translational initiation (GO:0006413)2.98662213
116ribosomal small subunit assembly (GO:0000028)2.98234083
117regulation of sister chromatid cohesion (GO:0007063)2.98130595
118mitotic cell cycle (GO:0000278)2.94825094
119positive regulation of mitotic sister chromatid separation (GO:1901970)2.92915273
120positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.92915273
121positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.92915273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.93092281
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.94337871
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.28735816
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99785329
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48917897
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.44298055
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20552304
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.07006326
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87249195
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.85337623
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78244781
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.77647053
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75309866
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69288246
15* GABP_17652178_ChIP-ChIP_JURKAT_Human2.67255069
16AR_21909140_ChIP-Seq_LNCAP_Human2.59739645
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50053218
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41170001
19XRN2_22483619_ChIP-Seq_HELA_Human2.30545203
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19955285
21* VDR_23849224_ChIP-Seq_CD4+_Human2.16089674
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14796198
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.11879696
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01630725
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98275145
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97583084
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.97398595
28DCP1A_22483619_ChIP-Seq_HELA_Human1.97122739
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96964708
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96827769
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89066839
32FOXP3_21729870_ChIP-Seq_TREG_Human1.86825780
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85667149
34GABP_19822575_ChIP-Seq_HepG2_Human1.83682031
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83006383
36TTF2_22483619_ChIP-Seq_HELA_Human1.77186055
37ZNF263_19887448_ChIP-Seq_K562_Human1.76474845
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75059103
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68876835
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62748347
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60879362
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57622962
43ELK1_19687146_ChIP-ChIP_HELA_Human1.57151163
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53721661
45KDM5A_27292631_Chip-Seq_BREAST_Human1.51220326
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50780807
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49746800
48CIITA_25753668_ChIP-Seq_RAJI_Human1.49741085
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46325368
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.46245483
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45920258
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39327776
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36159775
54MYC_22102868_ChIP-Seq_BL_Human1.34826922
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34039025
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33736135
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33610543
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32424789
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31348945
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30423610
61HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28883426
62* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28128897
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.25424577
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25367621
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24305556
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21935920
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19547662
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18323647
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18307193
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.14864214
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14753091
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12755810
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12163149
74TFEB_21752829_ChIP-Seq_HELA_Human1.10355944
75* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09105501
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08862894
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06383124
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05440443
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02332033
80* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01120530
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00923863
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99599646
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.99168074
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98645135
85SALL1_21062744_ChIP-ChIP_HESCs_Human0.97501439
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97295500
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97208750
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95293138
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95022812
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.92989794
91NANOG_21062744_ChIP-ChIP_HESCs_Human0.92416096
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90446734
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89987472
94* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89888380
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89650346
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89650346
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89650346
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89384091
99MYC_18940864_ChIP-ChIP_HL60_Human0.88992597
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.88045948
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87710892
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86990189
103* CHD1_26751641_Chip-Seq_LNCaP_Human0.86919726
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86866337
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85646735
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85330245
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84724913
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83423218
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83111905
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81112692
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80307282
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79183813
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78299939
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77535424
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77503404
116SPI1_23547873_ChIP-Seq_NB4_Human0.76733541
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76148813
118SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75447122
119ATF3_27146783_Chip-Seq_COLON_Human0.74693588
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74379265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.13908045
2MP0003111_abnormal_nucleus_morphology5.03073607
3MP0010094_abnormal_chromosome_stability4.90627894
4MP0004957_abnormal_blastocyst_morpholog4.76601732
5MP0003077_abnormal_cell_cycle4.27365514
6MP0008057_abnormal_DNA_replication4.02149868
7* MP0008058_abnormal_DNA_repair2.94448163
8MP0008932_abnormal_embryonic_tissue2.90867256
9MP0008007_abnormal_cellular_replicative2.82354311
10MP0003123_paternal_imprinting2.79507294
11MP0001730_embryonic_growth_arrest2.62410352
12MP0000350_abnormal_cell_proliferation2.38535464
13MP0002877_abnormal_melanocyte_morpholog2.37842313
14MP0003786_premature_aging2.20244406
15MP0008877_abnormal_DNA_methylation2.17401040
16MP0010352_gastrointestinal_tract_polyps2.12070446
17MP0010307_abnormal_tumor_latency2.09843077
18MP0003718_maternal_effect2.08676768
19MP0002396_abnormal_hematopoietic_system2.04272663
20MP0001672_abnormal_embryogenesis/_devel2.01848273
21MP0005380_embryogenesis_phenotype2.01848273
22MP0001697_abnormal_embryo_size1.90484981
23MP0009697_abnormal_copulation1.85746234
24MP0004233_abnormal_muscle_weight1.82717315
25MP0005623_abnormal_meninges_morphology1.80542226
26MP0003984_embryonic_growth_retardation1.79784224
27MP0002088_abnormal_embryonic_growth/wei1.75777913
28MP0002080_prenatal_lethality1.73187644
29MP0002085_abnormal_embryonic_tissue1.67205920
30MP0003567_abnormal_fetal_cardiomyocyte1.61350070
31MP0002086_abnormal_extraembryonic_tissu1.54907735
32MP0002084_abnormal_developmental_patter1.53347774
33MP0000490_abnormal_crypts_of1.50885396
34MP0004197_abnormal_fetal_growth/weight/1.45302471
35MP0000313_abnormal_cell_death1.44878736
36MP0010030_abnormal_orbit_morphology1.42507928
37MP0004808_abnormal_hematopoietic_stem1.39525764
38MP0001661_extended_life_span1.38244242
39MP0002019_abnormal_tumor_incidence1.34647974
40MP0001346_abnormal_lacrimal_gland1.32357923
41MP0010234_abnormal_vibrissa_follicle1.29709766
42* MP0002210_abnormal_sex_determination1.29476889
43MP0005076_abnormal_cell_differentiation1.28641186
44MP0005501_abnormal_skin_physiology1.27345047
45MP0001293_anophthalmia1.25283911
46MP0003121_genomic_imprinting1.25194218
47MP0003890_abnormal_embryonic-extraembry1.21442575
48MP0003315_abnormal_perineum_morphology1.19193244
49MP0009333_abnormal_splenocyte_physiolog1.15237206
50* MP0001145_abnormal_male_reproductive1.13651592
51MP0003941_abnormal_skin_development1.10970806
52MP0002697_abnormal_eye_size1.09424258
53MP0000579_abnormal_nail_morphology1.06792500
54MP0001545_abnormal_hematopoietic_system1.05442801
55MP0005397_hematopoietic_system_phenotyp1.05442801
56MP0009672_abnormal_birth_weight1.03116211
57MP0004185_abnormal_adipocyte_glucose1.02003601
58MP0003221_abnormal_cardiomyocyte_apopto1.01229622
59MP0006036_abnormal_mitochondrial_physio1.00912827
60MP0003806_abnormal_nucleotide_metabolis0.99287132
61MP0000537_abnormal_urethra_morphology0.99021826
62MP0009053_abnormal_anal_canal0.98674871
63MP0003119_abnormal_digestive_system0.96790717
64* MP0001929_abnormal_gametogenesis0.96239412
65MP0002796_impaired_skin_barrier0.95977384
66MP0003937_abnormal_limbs/digits/tail_de0.95256370
67* MP0000653_abnormal_sex_gland0.94314330
68MP0002160_abnormal_reproductive_system0.94008189
69MP0000358_abnormal_cell_content/0.91231148
70MP0000678_abnormal_parathyroid_gland0.90847050
71MP0003950_abnormal_plasma_membrane0.85390965
72MP0000703_abnormal_thymus_morphology0.85196005
73MP0005384_cellular_phenotype0.84750701
74MP0003705_abnormal_hypodermis_morpholog0.82153813
75MP0005621_abnormal_cell_physiology0.81139021
76MP0002722_abnormal_immune_system0.77592214
77* MP0002111_abnormal_tail_morphology0.76840913
78MP0005389_reproductive_system_phenotype0.76545092
79MP0000428_abnormal_craniofacial_morphol0.76456950
80MP0009703_decreased_birth_body0.76163249
81MP0002398_abnormal_bone_marrow0.73082568
82MP0005408_hypopigmentation0.72482412
83* MP0001119_abnormal_female_reproductive0.72073921
84MP0002234_abnormal_pharynx_morphology0.71433460
85MP0000762_abnormal_tongue_morphology0.71172655
86* MP0002161_abnormal_fertility/fecundity0.71116328
87MP0000689_abnormal_spleen_morphology0.70613520
88MP0002092_abnormal_eye_morphology0.70185664
89MP0008260_abnormal_autophagy0.70184817
90MP0000858_altered_metastatic_potential0.69222729
91MP0002060_abnormal_skin_morphology0.68921031
92MP0000003_abnormal_adipose_tissue0.68243883
93* MP0003698_abnormal_male_reproductive0.68063951
94MP0003186_abnormal_redox_activity0.67866969
95MP0000750_abnormal_muscle_regeneration0.67775704
96MP0005023_abnormal_wound_healing0.67522798
97MP0001188_hyperpigmentation0.67507868
98MP0006292_abnormal_olfactory_placode0.64641754
99MP0001286_abnormal_eye_development0.63776159
100MP0009278_abnormal_bone_marrow0.63685243
101MP0000049_abnormal_middle_ear0.62551735
102MP0002132_abnormal_respiratory_system0.62276595
103MP0003566_abnormal_cell_adhesion0.62121227
104MP0001881_abnormal_mammary_gland0.61651215
105MP0001727_abnormal_embryo_implantation0.60933941
106MP0009379_abnormal_foot_pigmentation0.59332173
107MP0001915_intracranial_hemorrhage0.59240380
108MP0000432_abnormal_head_morphology0.58847848
109MP0003385_abnormal_body_wall0.58383166
110MP0003755_abnormal_palate_morphology0.58086543
111MP0000372_irregular_coat_pigmentation0.57996970
112MP0003861_abnormal_nervous_system0.57981180
113MP0002269_muscular_atrophy0.57861833
114MP0002429_abnormal_blood_cell0.57547408
115MP0005171_absent_coat_pigmentation0.57468521
116MP0003943_abnormal_hepatobiliary_system0.57448237
117MP0008789_abnormal_olfactory_epithelium0.57257010
118MP0000733_abnormal_muscle_development0.56190789
119MP0003878_abnormal_ear_physiology0.55817736
120MP0005377_hearing/vestibular/ear_phenot0.55817736
121MP0005395_other_phenotype0.55384106
122MP0003936_abnormal_reproductive_system0.55022129
123MP0003763_abnormal_thymus_physiology0.54924048
124MP0001849_ear_inflammation0.53067706
125MP0000627_abnormal_mammary_gland0.52599852
126MP0003448_altered_tumor_morphology0.51462086
127MP0002938_white_spotting0.51097476
128MP0000477_abnormal_intestine_morphology0.51005905
129MP0003699_abnormal_female_reproductive0.50329394
130MP0001919_abnormal_reproductive_system0.50275285
131MP0003935_abnormal_craniofacial_develop0.48988749
132MP0004133_heterotaxia0.47805052
133MP0006035_abnormal_mitochondrial_morpho0.47424002
134MP0006054_spinal_hemorrhage0.45569710

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.79004563
2Breast hypoplasia (HP:0003187)4.75659774
3Chromsome breakage (HP:0040012)3.76683795
4Patellar aplasia (HP:0006443)3.74203013
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.62043792
6Reticulocytopenia (HP:0001896)3.59312699
7Aplasia/Hypoplasia of the patella (HP:0006498)3.56497863
8Colon cancer (HP:0003003)3.54513260
9Carpal bone hypoplasia (HP:0001498)3.53992914
10Impulsivity (HP:0100710)3.49992536
11Abnormality of the anterior horn cell (HP:0006802)3.40935384
12Degeneration of anterior horn cells (HP:0002398)3.40935384
13Oral leukoplakia (HP:0002745)3.34053250
14Rough bone trabeculation (HP:0100670)3.33133577
15Selective tooth agenesis (HP:0001592)3.27927735
16Abnormality of chromosome stability (HP:0003220)3.20744284
17Meckel diverticulum (HP:0002245)3.17293380
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.17158509
19Absent radius (HP:0003974)3.14022917
20Abnormality of cells of the erythroid lineage (HP:0012130)3.13863145
21Ependymoma (HP:0002888)3.13150363
22Microvesicular hepatic steatosis (HP:0001414)3.10051522
23Abnormality of the labia minora (HP:0012880)3.09278414
24Abnormal number of erythroid precursors (HP:0012131)3.02895347
25Abnormality of the preputium (HP:0100587)2.99730574
26Abnormality of the ileum (HP:0001549)2.98258834
27Cerebral hypomyelination (HP:0006808)2.97596096
28Medulloblastoma (HP:0002885)2.97047898
29Absent forearm bone (HP:0003953)2.91766192
30Aplasia involving forearm bones (HP:0009822)2.91766192
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.74855178
32Abnormality of glycolysis (HP:0004366)2.70304235
33Absent thumb (HP:0009777)2.70046914
34Rhabdomyosarcoma (HP:0002859)2.67677631
35Small intestinal stenosis (HP:0012848)2.66668361
36Duodenal stenosis (HP:0100867)2.66668361
37Agnosia (HP:0010524)2.59276111
38Neoplasm of the pancreas (HP:0002894)2.54170619
39Myelodysplasia (HP:0002863)2.46639096
40Premature graying of hair (HP:0002216)2.46329755
41Microretrognathia (HP:0000308)2.46050156
42Facial cleft (HP:0002006)2.45819437
43Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.45785988
44Macrocytic anemia (HP:0001972)2.45778623
45Bone marrow hypocellularity (HP:0005528)2.43897101
46Supernumerary spleens (HP:0009799)2.43150007
47Increased serum pyruvate (HP:0003542)2.42070536
48Abnormal trabecular bone morphology (HP:0100671)2.40554555
49Atresia of the external auditory canal (HP:0000413)2.40085732
50Horseshoe kidney (HP:0000085)2.39742540
51Abnormal lung lobation (HP:0002101)2.36430683
52Hypoplasia of the capital femoral epiphysis (HP:0003090)2.33098303
53Sloping forehead (HP:0000340)2.32096461
54Ureteral duplication (HP:0000073)2.32035045
55Ectopic kidney (HP:0000086)2.31587162
56Trismus (HP:0000211)2.30936218
57Multiple enchondromatosis (HP:0005701)2.30878753
58Premature ovarian failure (HP:0008209)2.28735549
59Volvulus (HP:0002580)2.28210640
60Aplastic anemia (HP:0001915)2.27130010
61Secondary amenorrhea (HP:0000869)2.26261043
62Facial hemangioma (HP:0000329)2.25862982
63Abnormal umbilical cord blood vessels (HP:0011403)2.24485504
64Single umbilical artery (HP:0001195)2.24485504
65Abnormality of the fetal cardiovascular system (HP:0010948)2.24485504
66Proximal placement of thumb (HP:0009623)2.24082426
67Abnormality of the umbilical cord (HP:0010881)2.20804561
68Broad distal phalanx of finger (HP:0009836)2.20595742
69Cleft eyelid (HP:0000625)2.19708050
70Glioma (HP:0009733)2.17855478
71Deviation of the thumb (HP:0009603)2.17831756
72Ragged-red muscle fibers (HP:0003200)2.17119522
73Abnormality of the duodenum (HP:0002246)2.16337527
74Tracheoesophageal fistula (HP:0002575)2.15455946
75Pallor (HP:0000980)2.12744860
76Increased nuchal translucency (HP:0010880)2.11717015
7711 pairs of ribs (HP:0000878)2.08726272
78Cellular immunodeficiency (HP:0005374)2.07260290
79Choanal atresia (HP:0000453)2.06897075
80Slender long bone (HP:0003100)2.06472512
81Embryonal renal neoplasm (HP:0011794)2.06101478
82Cutaneous melanoma (HP:0012056)2.05385094
83Abnormality of cochlea (HP:0000375)2.05332951
84Triphalangeal thumb (HP:0001199)2.04077724
85Type I transferrin isoform profile (HP:0003642)2.03266901
86Glossoptosis (HP:0000162)2.02249175
87Abnormal number of incisors (HP:0011064)2.01728398
88Short thumb (HP:0009778)2.01624146
89Cafe-au-lait spot (HP:0000957)2.01384543
90Basal cell carcinoma (HP:0002671)2.00959832
91Aplasia/hypoplasia of the humerus (HP:0006507)2.00940943
92Squamous cell carcinoma (HP:0002860)2.00855139
93Atrophy/Degeneration involving motor neurons (HP:0007373)2.00172133
94Abnormal mitochondria in muscle tissue (HP:0008316)1.99613687
95Overlapping toe (HP:0001845)1.98659013
96Prominent nose (HP:0000448)1.98244693
97Abnormality of the astrocytes (HP:0100707)1.98129715
98Astrocytoma (HP:0009592)1.98129715
99Sparse eyelashes (HP:0000653)1.95463167
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.93984622
101Poikiloderma (HP:0001029)1.92558347
102Megaloblastic anemia (HP:0001889)1.92330841
103Duplicated collecting system (HP:0000081)1.91768563
104Abnormalities of placenta or umbilical cord (HP:0001194)1.91454268
105Neoplasm of striated muscle (HP:0009728)1.90968487
106Pelvic girdle muscle weakness (HP:0003749)1.89225951
107Cerebral edema (HP:0002181)1.89008724
108Spinal muscular atrophy (HP:0007269)1.88280422
109Irregular epiphyses (HP:0010582)1.88149193
110Abnormality of the distal phalanges of the toes (HP:0010182)1.86865006
111Abnormality of the carotid arteries (HP:0005344)1.86264356
112Testicular atrophy (HP:0000029)1.86133953
113Sparse lateral eyebrow (HP:0005338)1.85558607
114Oligodactyly (HP:0012165)1.84559386
115Neoplasm of the colon (HP:0100273)1.84143837
116Entropion (HP:0000621)1.83384120
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82468360
118Abnormality of alanine metabolism (HP:0010916)1.82468360
119Hyperalaninemia (HP:0003348)1.82468360
120Breast aplasia (HP:0100783)1.81472282
121Increased serum lactate (HP:0002151)1.81352497
122Nephroblastoma (Wilms tumor) (HP:0002667)1.81351337
123Abnormal spermatogenesis (HP:0008669)1.80427397
124Gout (HP:0001997)1.77980593
125Progressive muscle weakness (HP:0003323)1.77577511
126Pancytopenia (HP:0001876)1.77351962
127Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77208160
128Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77208160
129Reduced antithrombin III activity (HP:0001976)1.76518355
130Hypoplasia of the radius (HP:0002984)1.75995885
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75802983
132Absent epiphyses (HP:0010577)1.75802983
133Biliary tract neoplasm (HP:0100574)1.74489657
134Abnormality of the calcaneus (HP:0008364)1.72303927
135Progressive external ophthalmoplegia (HP:0000590)1.72244899
136Clubbing of toes (HP:0100760)1.69036666
137Abnormality of DNA repair (HP:0003254)1.69004916
138Hyperacusis (HP:0010780)1.67883090
139Increased CSF lactate (HP:0002490)1.67501612
140Deep philtrum (HP:0002002)1.67287405
141Cortical dysplasia (HP:0002539)1.66118433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.60635850
2WEE14.92344871
3CDC73.91008096
4EIF2AK13.19873650
5NEK23.17057812
6TTK2.65085688
7NEK12.61434923
8MST1R2.56844180
9SRPK12.53857421
10BRSK22.51303058
11PLK42.51143911
12TSSK62.42248640
13ACVR1B2.33570397
14VRK22.29371555
15PLK12.22806897
16STK161.97043788
17NME21.89964808
18PLK31.87290712
19EIF2AK31.81046637
20MKNK11.80447612
21AURKB1.76881910
22BRSK11.67351583
23TESK21.67300825
24SMG11.66217472
25EPHA21.60422370
26VRK11.58687941
27DYRK31.58465087
28CDK71.58081751
29RPS6KA41.58045453
30TLK11.56448081
31CHEK21.53764122
32ATR1.52134044
33MKNK21.51491436
34MET1.42460444
35MAP3K81.38601290
36CDK121.32218876
37CDK41.31820147
38ZAK1.31130802
39CCNB11.30050775
40AURKA1.28806445
41CHEK11.21648125
42STK101.17969108
43STK41.16405554
44PASK1.15156853
45RPS6KB21.13847830
46MST41.02381824
47PAK40.99183044
48ICK0.98123957
49STK30.92034970
50MELK0.87926704
51TAF10.87178250
52SCYL20.85566960
53ALK0.85349225
54CDK20.84863864
55LATS20.84482621
56ATM0.83522238
57EIF2AK20.80983025
58TRIM280.79358145
59STK38L0.77422254
60PIM10.76936863
61AKT30.75013200
62PAK10.73133844
63PNCK0.73075445
64BRAF0.72589980
65PTK20.70621041
66TGFBR10.69285946
67CDK60.68571367
68ERBB40.68274976
69PBK0.65871905
70CDK10.64866265
71CSNK2A10.61895702
72CSNK2A20.61151436
73EEF2K0.61053183
74PIM20.59501200
75CDK80.56332486
76KDR0.53295066
77NEK90.50644866
78LATS10.49931557
79BRD40.49290410
80PRKCI0.49076531
81TRIB30.48079699
82RPS6KA50.43433218
83MAP3K100.42892052
84TESK10.40811129
85AKT20.39631339
86MAP3K110.39416151
87MAPKAPK50.39294163
88FLT30.38907641
89LIMK10.38367309
90TTN0.37971895
91RAF10.36985083
92MTOR0.36429217
93ILK0.36189747
94LRRK20.36064510
95ARAF0.35289847
96DAPK10.34939867
97CSNK1E0.34759209
98MARK30.33934358
99CLK10.33888682
100MAP2K30.33594801
101PDK30.33010734
102PDK40.33010734
103CSNK1G30.32778865
104CDK11A0.31735537
105NME10.30366246
106CDK180.30128185
107CDK150.29006605
108PKN20.28352218
109PRKDC0.28088508
110MAP4K10.27950873
111MAPK110.27690659
112CDK140.25975261
113CDK90.25126964
114NEK60.24919912
115CDK30.24828286
116MAP3K50.24186241
117BLK0.18861806
118MAPK140.18387479
119MAP3K30.18180116
120PDK20.16779175
121STK240.16623420
122PAK20.16551990
123TAOK20.15788974
124ABL20.15276737
125IRAK30.13460716
126NUAK10.13357749
127MAPKAPK20.12503953

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.94637210
2Mismatch repair_Homo sapiens_hsa034304.23716037
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.99956123
4RNA transport_Homo sapiens_hsa030133.41696469
5RNA polymerase_Homo sapiens_hsa030203.33666020
6Proteasome_Homo sapiens_hsa030503.29880082
7Spliceosome_Homo sapiens_hsa030403.27754293
8Homologous recombination_Homo sapiens_hsa034403.09163410
9Cell cycle_Homo sapiens_hsa041103.07305088
10Base excision repair_Homo sapiens_hsa034102.98572735
11Ribosome_Homo sapiens_hsa030102.91534532
12Nucleotide excision repair_Homo sapiens_hsa034202.88179102
13One carbon pool by folate_Homo sapiens_hsa006702.59309959
14Pyrimidine metabolism_Homo sapiens_hsa002402.48366772
15Fanconi anemia pathway_Homo sapiens_hsa034602.35177384
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32101803
17Basal transcription factors_Homo sapiens_hsa030222.04846355
18Vitamin B6 metabolism_Homo sapiens_hsa007501.88669376
19Non-homologous end-joining_Homo sapiens_hsa034501.83210413
20RNA degradation_Homo sapiens_hsa030181.80586402
21p53 signaling pathway_Homo sapiens_hsa041151.79065632
22mRNA surveillance pathway_Homo sapiens_hsa030151.74318391
23Pyruvate metabolism_Homo sapiens_hsa006201.42031485
24Purine metabolism_Homo sapiens_hsa002301.33407288
25Epstein-Barr virus infection_Homo sapiens_hsa051691.27041864
26Oocyte meiosis_Homo sapiens_hsa041141.23873440
27Systemic lupus erythematosus_Homo sapiens_hsa053221.19422520
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15340988
29Folate biosynthesis_Homo sapiens_hsa007901.15196475
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11022059
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05426827
32Parkinsons disease_Homo sapiens_hsa050121.04683288
33Viral carcinogenesis_Homo sapiens_hsa052030.98106359
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95396606
35Oxidative phosphorylation_Homo sapiens_hsa001900.92164201
36Fatty acid elongation_Homo sapiens_hsa000620.91669802
37Herpes simplex infection_Homo sapiens_hsa051680.91064273
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.90424220
39Pentose phosphate pathway_Homo sapiens_hsa000300.89367886
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87560948
41Antigen processing and presentation_Homo sapiens_hsa046120.86817987
42Biosynthesis of amino acids_Homo sapiens_hsa012300.82459322
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.79334264
44Selenocompound metabolism_Homo sapiens_hsa004500.79244245
45HTLV-I infection_Homo sapiens_hsa051660.72643350
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.65352441
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63335483
48MicroRNAs in cancer_Homo sapiens_hsa052060.63267426
49Phenylalanine metabolism_Homo sapiens_hsa003600.61853898
50Small cell lung cancer_Homo sapiens_hsa052220.61303633
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59471808
52Legionellosis_Homo sapiens_hsa051340.59308845
53Thyroid cancer_Homo sapiens_hsa052160.58756537
54Lysine degradation_Homo sapiens_hsa003100.57746685
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57039285
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55264660
57Alzheimers disease_Homo sapiens_hsa050100.55078375
58Sulfur relay system_Homo sapiens_hsa041220.53939187
59Steroid biosynthesis_Homo sapiens_hsa001000.48992780
60Propanoate metabolism_Homo sapiens_hsa006400.47348901
61Arginine biosynthesis_Homo sapiens_hsa002200.47246752
62Glutathione metabolism_Homo sapiens_hsa004800.46491187
63Hippo signaling pathway_Homo sapiens_hsa043900.45694340
64Apoptosis_Homo sapiens_hsa042100.41840860
65Carbon metabolism_Homo sapiens_hsa012000.41240010
66Tyrosine metabolism_Homo sapiens_hsa003500.40921009
67TGF-beta signaling pathway_Homo sapiens_hsa043500.40584216
68Regulation of autophagy_Homo sapiens_hsa041400.39274036
69Fructose and mannose metabolism_Homo sapiens_hsa000510.37656407
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37090092
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36682719
72Protein export_Homo sapiens_hsa030600.36190316
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34835491
74Arginine and proline metabolism_Homo sapiens_hsa003300.33743399
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33695618
76Alcoholism_Homo sapiens_hsa050340.33620361
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33350411
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31408481
79Hepatitis B_Homo sapiens_hsa051610.29986686
80Colorectal cancer_Homo sapiens_hsa052100.29098503
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27411735
82mTOR signaling pathway_Homo sapiens_hsa041500.26953705
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26895351
84Pancreatic cancer_Homo sapiens_hsa052120.26684717
85Huntingtons disease_Homo sapiens_hsa050160.26323084
86Fatty acid metabolism_Homo sapiens_hsa012120.26296497
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26245112
88Shigellosis_Homo sapiens_hsa051310.26207407
89HIF-1 signaling pathway_Homo sapiens_hsa040660.25991364
90Renin-angiotensin system_Homo sapiens_hsa046140.25514389
91Basal cell carcinoma_Homo sapiens_hsa052170.24929845
92Measles_Homo sapiens_hsa051620.22686445
93Bladder cancer_Homo sapiens_hsa052190.22660786
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22363621
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.21663873
96Hedgehog signaling pathway_Homo sapiens_hsa043400.20391172
97Pathways in cancer_Homo sapiens_hsa052000.19754868
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19434624
99Influenza A_Homo sapiens_hsa051640.19177861
100Adherens junction_Homo sapiens_hsa045200.16915100
101Prostate cancer_Homo sapiens_hsa052150.16851742
102Vitamin digestion and absorption_Homo sapiens_hsa049770.16777765
103Chronic myeloid leukemia_Homo sapiens_hsa052200.16179507
104Metabolic pathways_Homo sapiens_hsa011000.16103567
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15425983
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.15250497
107Galactose metabolism_Homo sapiens_hsa000520.14727414
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.13852375
109N-Glycan biosynthesis_Homo sapiens_hsa005100.13748748
110Sulfur metabolism_Homo sapiens_hsa009200.13704934
111Viral myocarditis_Homo sapiens_hsa054160.13640250
112Melanoma_Homo sapiens_hsa052180.12916247
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12280980
114Non-small cell lung cancer_Homo sapiens_hsa052230.11772448
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11769739
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11564946
117FoxO signaling pathway_Homo sapiens_hsa040680.11507867
118Primary immunodeficiency_Homo sapiens_hsa053400.11414680
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11092841
120Notch signaling pathway_Homo sapiens_hsa043300.10767893
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09860701
122Vibrio cholerae infection_Homo sapiens_hsa051100.09116685
123Tight junction_Homo sapiens_hsa045300.07818947
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07433961
125Hematopoietic cell lineage_Homo sapiens_hsa046400.05190030

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