TRIP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.11181246
2translational termination (GO:0006415)4.94022619
3ribosomal small subunit assembly (GO:0000028)4.69414448
4translational elongation (GO:0006414)4.39984155
5ribosomal small subunit biogenesis (GO:0042274)4.29705044
6maturation of SSU-rRNA (GO:0030490)4.26492021
7nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.00103768
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99946839
9protein targeting to ER (GO:0045047)3.88852915
10cotranslational protein targeting to membrane (GO:0006613)3.85332836
11translational initiation (GO:0006413)3.84597731
12protein retention in ER lumen (GO:0006621)3.78345711
13viral life cycle (GO:0019058)3.77651451
14negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.71107741
15cellular protein complex disassembly (GO:0043624)3.69713830
16establishment of protein localization to endoplasmic reticulum (GO:0072599)3.67812643
17COPI coating of Golgi vesicle (GO:0048205)3.67464903
18Golgi transport vesicle coating (GO:0048200)3.67464903
19protein heterotrimerization (GO:0070208)3.66777468
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62710025
21G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.59791237
22protein localization to endoplasmic reticulum (GO:0070972)3.57234085
23protein maturation by protein folding (GO:0022417)3.51335017
24regulation of mammary gland epithelial cell proliferation (GO:0033599)3.49753228
25proline biosynthetic process (GO:0006561)3.48687747
26outer ear morphogenesis (GO:0042473)3.44197386
27formation of translation preinitiation complex (GO:0001731)3.43779429
28protein complex disassembly (GO:0043241)3.37301169
29ribosomal large subunit biogenesis (GO:0042273)3.34886580
30hemidesmosome assembly (GO:0031581)3.33547956
31paraxial mesoderm development (GO:0048339)3.32677330
32nucleobase-containing small molecule interconversion (GO:0015949)3.27828327
33planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26502603
34endothelial cell morphogenesis (GO:0001886)3.15258937
35DNA deamination (GO:0045006)3.15153374
36cellular protein complex localization (GO:0034629)3.14692922
37tooth mineralization (GO:0034505)3.14205454
38DNA unwinding involved in DNA replication (GO:0006268)3.13350489
39protein complex localization (GO:0031503)3.13020084
40histone arginine methylation (GO:0034969)3.12720830
41nuclear envelope reassembly (GO:0031468)3.11991808
42mitotic nuclear envelope reassembly (GO:0007084)3.11991808
43macromolecular complex disassembly (GO:0032984)3.10964554
44mitotic chromosome condensation (GO:0007076)3.05478344
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03085813
46ribonucleoprotein complex biogenesis (GO:0022613)2.92822343
47chondrocyte proliferation (GO:0035988)2.91432432
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88249086
49regulation of translational termination (GO:0006449)2.87469194
50folic acid-containing compound biosynthetic process (GO:0009396)2.84534658
51pentose-phosphate shunt (GO:0006098)2.84444227
52regulation of early endosome to late endosome transport (GO:2000641)2.84234678
53nuclear-transcribed mRNA catabolic process (GO:0000956)2.84009727
54regulation of posttranscriptional gene silencing (GO:0060147)2.83825363
55regulation of gene silencing by miRNA (GO:0060964)2.83825363
56regulation of gene silencing by RNA (GO:0060966)2.83825363
57collagen fibril organization (GO:0030199)2.82985205
58apoptotic process involved in morphogenesis (GO:0060561)2.81721584
59establishment of apical/basal cell polarity (GO:0035089)2.80121399
60desmosome organization (GO:0002934)2.77658737
61cochlea morphogenesis (GO:0090103)2.75853211
62pattern specification involved in kidney development (GO:0061004)2.75470380
63mesenchymal-epithelial cell signaling (GO:0060638)2.75381212
64polarized epithelial cell differentiation (GO:0030859)2.74467279
65rRNA transcription (GO:0009303)2.72818425
66protein localization to kinetochore (GO:0034501)2.72696074
67* cell-substrate junction assembly (GO:0007044)2.72230727
68protein targeting to membrane (GO:0006612)2.71421178
69IMP biosynthetic process (GO:0006188)2.70745455
70basement membrane organization (GO:0071711)2.70670968
71mitotic G1 DNA damage checkpoint (GO:0031571)2.68053934
72mRNA catabolic process (GO:0006402)2.68023128
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.67456362
74cell migration involved in heart development (GO:0060973)2.67406397
75GDP-mannose metabolic process (GO:0019673)2.64251900
76UV protection (GO:0009650)2.63743770
77protein localization to endosome (GO:0036010)2.62799197
78* adherens junction assembly (GO:0034333)2.62591213
79negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.60772486
80ventricular cardiac muscle cell development (GO:0055015)2.60762748
81dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.60292104
82regulation of SMAD protein import into nucleus (GO:0060390)2.59428512
83skin morphogenesis (GO:0043589)2.58449246
84barbed-end actin filament capping (GO:0051016)2.56826896
85peptidyl-arginine omega-N-methylation (GO:0035247)2.56008573
86RNA catabolic process (GO:0006401)2.55380464
87peptidyl-arginine N-methylation (GO:0035246)2.55217834
88peptidyl-arginine methylation (GO:0018216)2.55217834
89regulation of apoptotic process involved in morphogenesis (GO:1902337)2.52914274
90mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.52695559
91DNA strand elongation involved in DNA replication (GO:0006271)2.52501711
92maternal placenta development (GO:0001893)2.51407239
93bone trabecula formation (GO:0060346)2.51153916
94pentose metabolic process (GO:0019321)2.51035197
95translation (GO:0006412)2.50781071
96hippo signaling (GO:0035329)2.49736611
97pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.49459012
98convergent extension (GO:0060026)2.49143096
99positive regulation of SMAD protein import into nucleus (GO:0060391)2.49049689
100regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48908904
101NADPH regeneration (GO:0006740)2.48090301
102positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.48077678
103glucose catabolic process (GO:0006007)2.47137051
104muscle cell migration (GO:0014812)2.46615046
105regulation of gastrulation (GO:0010470)2.45768775
106pinocytosis (GO:0006907)2.45639691
107regulation of hippo signaling (GO:0035330)2.44835013
108positive regulation of epithelial to mesenchymal transition (GO:0010718)2.43676640
109pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.42907332
110mesenchymal cell proliferation (GO:0010463)2.42828035
111endodermal cell differentiation (GO:0035987)2.42685112
112heterochromatin organization (GO:0070828)2.42635527
113mitotic nuclear envelope disassembly (GO:0007077)2.42117146
114* focal adhesion assembly (GO:0048041)2.42110057
115* cell-substrate adherens junction assembly (GO:0007045)2.42110057
116IMP metabolic process (GO:0046040)2.41953962
117L-serine metabolic process (GO:0006563)2.41017599
118regulation of cardioblast differentiation (GO:0051890)2.40740100
119retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.40463985
120regulation of heart morphogenesis (GO:2000826)2.40050203
121DNA replication initiation (GO:0006270)2.39804462
122atrioventricular valve morphogenesis (GO:0003181)2.39512444
123guanosine-containing compound biosynthetic process (GO:1901070)2.39018724
124UTP biosynthetic process (GO:0006228)2.38784311
125epithelial cell-cell adhesion (GO:0090136)2.38109003
126middle ear morphogenesis (GO:0042474)2.37964386
127regulation of mitotic spindle organization (GO:0060236)2.37557911
128spliceosomal tri-snRNP complex assembly (GO:0000244)2.37479179
129wound healing, spreading of epidermal cells (GO:0035313)2.36566700
130regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.36557809
131positive regulation of blood vessel endothelial cell migration (GO:0043536)2.36489227
132outflow tract septum morphogenesis (GO:0003148)2.35853230
133mitotic G1/S transition checkpoint (GO:0044819)2.35822663
134negative regulation of RNA splicing (GO:0033119)2.35231996
135DNA strand elongation (GO:0022616)2.35180616
136ribosome biogenesis (GO:0042254)2.30719674
137regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.30483512
138regulation of translational fidelity (GO:0006450)2.29504902
139negative regulation of cell cycle arrest (GO:0071157)2.28709016
140anatomical structure regression (GO:0060033)2.28164792
141branching involved in salivary gland morphogenesis (GO:0060445)2.27082611
142regulation of stem cell maintenance (GO:2000036)2.26753148
143glomerular basement membrane development (GO:0032836)2.26549147
144DNA replication-dependent nucleosome organization (GO:0034723)2.26406732
145DNA replication-dependent nucleosome assembly (GO:0006335)2.26406732
146telomere maintenance via semi-conservative replication (GO:0032201)2.25808806
147embryonic skeletal joint morphogenesis (GO:0060272)2.25454085
148cell proliferation involved in metanephros development (GO:0072203)2.24551744
149Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.24258289
150response to nitrosative stress (GO:0051409)2.23897409
151regulation of cell aging (GO:0090342)2.23859410
152nodal signaling pathway (GO:0038092)2.22136294
153negative regulation of chondrocyte differentiation (GO:0032331)2.21244225
154regulation of spindle organization (GO:0090224)2.21165589
155membrane disassembly (GO:0030397)2.20358175
156nuclear envelope disassembly (GO:0051081)2.20358175
157rRNA processing (GO:0006364)2.19793862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.43121207
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.89786362
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.87950151
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58786465
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72110984
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.59949376
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59741061
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.36227816
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.32656807
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27658598
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23062853
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18407378
13* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16865459
14XRN2_22483619_ChIP-Seq_HELA_Human2.11112016
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07401431
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.92888881
17CLOCK_20551151_ChIP-Seq_293T_Human1.91004960
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87743692
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84771657
20MYC_22102868_ChIP-Seq_BL_Human1.78696789
21AR_21909140_ChIP-Seq_LNCAP_Human1.77937472
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.76686692
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75618148
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75325586
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74160267
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73350784
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72996233
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72658906
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71446979
30ZNF263_19887448_ChIP-Seq_K562_Human1.66791528
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66567565
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.64409322
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.63294365
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61568587
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59750556
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56167203
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54785612
38* TET1_21451524_ChIP-Seq_MESCs_Mouse1.52423583
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51326551
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.51107352
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.51107352
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.51107352
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50963701
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.49163185
45VDR_21846776_ChIP-Seq_THP-1_Human1.47082712
46DCP1A_22483619_ChIP-Seq_HELA_Human1.46392562
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46139786
48TTF2_22483619_ChIP-Seq_HELA_Human1.46014904
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45864299
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45561588
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45354351
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43297149
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37390540
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37109268
55ATF3_27146783_Chip-Seq_COLON_Human1.35435674
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34463371
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33399427
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32946799
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32813116
60* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32226525
61* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31281154
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.29467732
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28622718
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27606313
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27393761
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26746776
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26117930
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.24136056
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23709660
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22645167
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22063478
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21769679
73CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21021219
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.20234372
75RACK7_27058665_Chip-Seq_MCF-7_Human1.19946164
76* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19206925
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19108326
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18997617
79* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18927821
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18783253
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18745488
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18461992
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17482144
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.16998428
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16540514
86GABP_19822575_ChIP-Seq_HepG2_Human1.16452060
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16265425
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.16004982
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15858805
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15798004
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14489174
92* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14342727
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14241764
94* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13975248
95* SA1_27219007_Chip-Seq_ERYTHROID_Human1.13808991
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12678778
97* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10541556
98P68_20966046_ChIP-Seq_HELA_Human1.09561122
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.08913369
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08900381
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07569204
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06520933
103* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06113108
104LXR_22292898_ChIP-Seq_THP-1_Human1.04432863
105TP53_22127205_ChIP-Seq_IMR90_Human1.02674508
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01869120
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01764042
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01759830
109CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01483652
110KDM2B_26808549_Chip-Seq_K562_Human1.01381428
111ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01023871
112FOXP3_21729870_ChIP-Seq_TREG_Human1.00064966
113* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99802699
114ELK1_22589737_ChIP-Seq_MCF10A_Human0.98479825
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97252814
116NCOR1_26117541_ChIP-Seq_K562_Human0.97078735
117KDM2B_26808549_Chip-Seq_DND41_Human0.96992642
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96971300
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96968342
120SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96162279
121* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95858041
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95464044
123* FOXP1_21924763_ChIP-Seq_HESCs_Human0.95293207
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95052949
125NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94468082
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94316182
127* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94092512
128TCF7_22412390_ChIP-Seq_EML_Mouse0.92294447
129UBF1/2_26484160_Chip-Seq_HMECs_Human0.91558423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.25332130
2MP0010030_abnormal_orbit_morphology3.58405911
3MP0003705_abnormal_hypodermis_morpholog3.48934483
4MP0005275_abnormal_skin_tensile2.82459676
5MP0004272_abnormal_basement_membrane2.18937920
6MP0009053_abnormal_anal_canal2.17423234
7MP0005503_abnormal_tendon_morphology2.13036761
8MP0009379_abnormal_foot_pigmentation2.02343291
9MP0003279_aneurysm1.97165503
10MP0010352_gastrointestinal_tract_polyps1.91484298
11MP0003566_abnormal_cell_adhesion1.82869801
12MP0006054_spinal_hemorrhage1.79420406
13MP0000537_abnormal_urethra_morphology1.79030546
14MP0005023_abnormal_wound_healing1.75784708
15MP0003942_abnormal_urinary_system1.75480117
16MP0004957_abnormal_blastocyst_morpholog1.70876521
17MP0004858_abnormal_nervous_system1.67891112
18MP0001958_emphysema1.66826705
19MP0003941_abnormal_skin_development1.65583592
20MP0010368_abnormal_lymphatic_system1.57968144
21MP0003453_abnormal_keratinocyte_physiol1.57258938
22MP0003385_abnormal_body_wall1.57089513
23MP0000579_abnormal_nail_morphology1.54883213
24MP0000049_abnormal_middle_ear1.53433625
25MP0002249_abnormal_larynx_morphology1.52943751
26MP0005508_abnormal_skeleton_morphology1.52779745
27MP0004233_abnormal_muscle_weight1.51424546
28MP0002060_abnormal_skin_morphology1.50990049
29MP0005058_abnormal_lysosome_morphology1.50527069
30MP0005623_abnormal_meninges_morphology1.49964855
31MP0005451_abnormal_body_composition1.47603589
32MP0008007_abnormal_cellular_replicative1.46765122
33MP0009250_abnormal_appendicular_skeleto1.39801957
34MP0002282_abnormal_trachea_morphology1.34619236
35MP0004185_abnormal_adipocyte_glucose1.34174934
36MP0008932_abnormal_embryonic_tissue1.33726417
37MP0009384_cardiac_valve_regurgitation1.33199518
38MP0000428_abnormal_craniofacial_morphol1.32368299
39MP0002932_abnormal_joint_morphology1.32003069
40MP0003115_abnormal_respiratory_system1.29365061
41MP0003077_abnormal_cell_cycle1.29245041
42MP0004197_abnormal_fetal_growth/weight/1.28137034
43MP0000003_abnormal_adipose_tissue1.28087614
44MP0001661_extended_life_span1.25578092
45MP0003693_abnormal_embryo_hatching1.25133690
46MP0010234_abnormal_vibrissa_follicle1.23558458
47MP0001293_anophthalmia1.22021949
48MP0000733_abnormal_muscle_development1.21487252
49MP0004808_abnormal_hematopoietic_stem1.21265143
50MP0000762_abnormal_tongue_morphology1.18306718
51MP0000750_abnormal_muscle_regeneration1.15416765
52MP0002111_abnormal_tail_morphology1.15037317
53MP0003123_paternal_imprinting1.14276542
54MP0003111_abnormal_nucleus_morphology1.13122176
55MP0002089_abnormal_postnatal_growth/wei1.11169731
56MP0009840_abnormal_foam_cell1.11037626
57MP0000534_abnormal_ureter_morphology1.10945092
58MP0002254_reproductive_system_inflammat1.10735657
59MP0005257_abnormal_intraocular_pressure1.09844335
60MP0000462_abnormal_digestive_system1.09483269
61MP0003567_abnormal_fetal_cardiomyocyte1.09357264
62MP0001542_abnormal_bone_strength1.08562552
63MP0002234_abnormal_pharynx_morphology1.07732699
64MP0001243_abnormal_dermal_layer1.07717953
65MP0001697_abnormal_embryo_size1.07618060
66MP0002085_abnormal_embryonic_tissue1.07402962
67MP0001348_abnormal_lacrimal_gland1.06746348
68MP0008260_abnormal_autophagy1.05761383
69MP0003755_abnormal_palate_morphology1.05615243
70MP0001672_abnormal_embryogenesis/_devel1.05266799
71MP0005380_embryogenesis_phenotype1.05266799
72MP0000350_abnormal_cell_proliferation1.05261994
73MP0002084_abnormal_developmental_patter1.05030725
74MP0001730_embryonic_growth_arrest1.04337477
75MP0000767_abnormal_smooth_muscle1.04010815
76MP0005076_abnormal_cell_differentiation1.03808283
77MP0003937_abnormal_limbs/digits/tail_de1.03615427
78MP0002088_abnormal_embryonic_growth/wei1.03087494
79MP0003935_abnormal_craniofacial_develop1.02994447
80MP0003984_embryonic_growth_retardation1.02135012
81MP0001216_abnormal_epidermal_layer1.01709738
82MP0002396_abnormal_hematopoietic_system1.01323548
83MP0003186_abnormal_redox_activity1.00902314
84MP0003119_abnormal_digestive_system1.00134889
85MP0001849_ear_inflammation0.99847380
86MP0010771_integument_phenotype0.98770245
87MP0002877_abnormal_melanocyte_morpholog0.97793694
88MP0000013_abnormal_adipose_tissue0.96133316
89MP0002086_abnormal_extraembryonic_tissu0.94717903
90MP0001879_abnormal_lymphatic_vessel0.94643180
91MP0000163_abnormal_cartilage_morphology0.93873277
92MP0010094_abnormal_chromosome_stability0.93223415
93MP0005501_abnormal_skin_physiology0.93159138
94MP0002092_abnormal_eye_morphology0.92577523
95MP0000432_abnormal_head_morphology0.92349762
96MP0002697_abnormal_eye_size0.90066088
97MP0002938_white_spotting0.89810860
98MP0000751_myopathy0.89575296
99MP0002080_prenatal_lethality0.89395386
100MP0001915_intracranial_hemorrhage0.88644473
101MP0005197_abnormal_uvea_morphology0.88506071
102MP0009278_abnormal_bone_marrow0.87605268
103MP0003091_abnormal_cell_migration0.85183343
104MP0002116_abnormal_craniofacial_bone0.84244284
105MP0002233_abnormal_nose_morphology0.83788462
106MP0009672_abnormal_birth_weight0.83269649
107MP0003806_abnormal_nucleotide_metabolis0.83141832
108MP0000759_abnormal_skeletal_muscle0.82618209
109MP0002796_impaired_skin_barrier0.82474490
110MP0010630_abnormal_cardiac_muscle0.81930573
111MP0005375_adipose_tissue_phenotype0.81785558
112MP0002925_abnormal_cardiovascular_devel0.81384041
113MP0002128_abnormal_blood_circulation0.80975318
114MP0001614_abnormal_blood_vessel0.80310082
115MP0000467_abnormal_esophagus_morphology0.80270534
116MP0003950_abnormal_plasma_membrane0.79977612
117MP0002896_abnormal_bone_mineralization0.79720359
118MP0005193_abnormal_anterior_eye0.79339728
119MP0005621_abnormal_cell_physiology0.77851153
120MP0000681_abnormal_thyroid_gland0.76494988
121MP0001881_abnormal_mammary_gland0.76276448
122MP0002115_abnormal_skeleton_extremities0.76167111
123MP0002098_abnormal_vibrissa_morphology0.76076343
124MP0000358_abnormal_cell_content/0.75583796
125MP0005666_abnormal_adipose_tissue0.75203286
126MP0003828_pulmonary_edema0.75165651
127MP0002113_abnormal_skeleton_development0.75124062
128MP0000678_abnormal_parathyroid_gland0.75028556
129MP0005397_hematopoietic_system_phenotyp0.74869167
130MP0001545_abnormal_hematopoietic_system0.74869167
131MP0003283_abnormal_digestive_organ0.74544741
132MP0003315_abnormal_perineum_morphology0.74218722
133MP0000858_altered_metastatic_potential0.74037321
134MP0002109_abnormal_limb_morphology0.73837371
135MP0009931_abnormal_skin_appearance0.73617333

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.89928318
2Premature rupture of membranes (HP:0001788)5.80376412
3Shallow orbits (HP:0000586)3.74885711
4Ankle contracture (HP:0006466)3.73905507
5Selective tooth agenesis (HP:0001592)3.42775890
6Biconcave vertebral bodies (HP:0004586)3.39921333
7Soft skin (HP:0000977)3.37644058
8Fragile skin (HP:0001030)3.33309146
9Aortic dissection (HP:0002647)3.32941825
10Atrophic scars (HP:0001075)3.26441196
11Vertebral compression fractures (HP:0002953)3.15274176
12Increased connective tissue (HP:0009025)2.95449881
13Aortic aneurysm (HP:0004942)2.94115951
14Peritonitis (HP:0002586)2.93463986
15Cerebral aneurysm (HP:0004944)2.90550877
16Reticulocytopenia (HP:0001896)2.80482019
17Neonatal short-limb short stature (HP:0008921)2.80072368
18Bladder diverticulum (HP:0000015)2.76327413
19Blue sclerae (HP:0000592)2.64033143
20Broad metatarsal (HP:0001783)2.56992460
21Insomnia (HP:0100785)2.56005716
22Spinal rigidity (HP:0003306)2.55095693
23Dilatation of the ascending aorta (HP:0005111)2.51059411
24Genu recurvatum (HP:0002816)2.46342519
25Trismus (HP:0000211)2.45808557
26Mitral valve prolapse (HP:0001634)2.42222908
27Abnormal hemoglobin (HP:0011902)2.40962271
28Overriding aorta (HP:0002623)2.40950553
29Abnormality of dentin (HP:0010299)2.39424237
30Broad distal phalanx of finger (HP:0009836)2.33489276
31Abnormality of cells of the erythroid lineage (HP:0012130)2.33049906
32Distal lower limb muscle weakness (HP:0009053)2.31545188
33Renal duplication (HP:0000075)2.29191692
34Premature skin wrinkling (HP:0100678)2.27781192
35Type 1 muscle fiber predominance (HP:0003803)2.26420520
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24964854
37Rough bone trabeculation (HP:0100670)2.22102842
38Wormian bones (HP:0002645)2.20519472
39Deviation of the hallux (HP:0010051)2.18500799
40Cervical subluxation (HP:0003308)2.16259626
41Entropion (HP:0000621)2.15786019
42Reduced subcutaneous adipose tissue (HP:0003758)2.13761528
43Hallux valgus (HP:0001822)2.13648865
44Upper limb amyotrophy (HP:0009129)2.13243807
45Distal upper limb amyotrophy (HP:0007149)2.13243807
46Abnormal delivery (HP:0001787)2.12758811
47Abnormal number of erythroid precursors (HP:0012131)2.11265755
48Progressive muscle weakness (HP:0003323)2.10401369
49Disproportionate tall stature (HP:0001519)2.07871453
50Colon cancer (HP:0003003)2.07764300
51Mesangial abnormality (HP:0001966)2.07511805
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06874919
53Short 4th metacarpal (HP:0010044)2.06874919
54Redundant skin (HP:0001582)2.06717286
55Flat cornea (HP:0007720)2.06177443
56Elfin facies (HP:0004428)2.05163579
57Abnormality of the distal phalanges of the toes (HP:0010182)2.04839567
58Bowel diverticulosis (HP:0005222)2.04297799
59Abnormality of the acetabulum (HP:0003170)2.04209512
60Coronal craniosynostosis (HP:0004440)2.03096206
61Stridor (HP:0010307)2.02608696
62Vascular tortuosity (HP:0004948)1.99848910
63Delayed cranial suture closure (HP:0000270)1.99745296
64Elbow flexion contracture (HP:0002987)1.99724234
65Abnormality of the peritoneum (HP:0002585)1.99529652
66Ulnar bowing (HP:0003031)1.99408268
67Patellar dislocation (HP:0002999)1.96586446
68Abnormality of the fetal cardiovascular system (HP:0010948)1.95350381
69Abnormal umbilical cord blood vessels (HP:0011403)1.95350381
70Single umbilical artery (HP:0001195)1.95350381
71Down-sloping shoulders (HP:0200021)1.95335919
72Short nail (HP:0001799)1.95170148
73Generalized amyotrophy (HP:0003700)1.94564078
74Long palpebral fissure (HP:0000637)1.92788585
75Short clavicles (HP:0000894)1.92681947
76Slender long bone (HP:0003100)1.92526890
77Microretrognathia (HP:0000308)1.92453939
78Advanced eruption of teeth (HP:0006288)1.92184704
79Spinal cord compression (HP:0002176)1.91915140
80Partial duplication of the phalanx of hand (HP:0009999)1.91872625
81Hyperextensible skin (HP:0000974)1.91792340
82Nonimmune hydrops fetalis (HP:0001790)1.91777794
83Distal lower limb amyotrophy (HP:0008944)1.89383243
84Achilles tendon contracture (HP:0001771)1.88699782
85Aneurysm (HP:0002617)1.88649823
86Multiple enchondromatosis (HP:0005701)1.88479533
87Wide anterior fontanel (HP:0000260)1.87452198
88Breech presentation (HP:0001623)1.87410424
89Arnold-Chiari malformation (HP:0002308)1.86855181
90Breast hypoplasia (HP:0003187)1.85598116
91Broad toe (HP:0001837)1.85547841
92Missing ribs (HP:0000921)1.84835778
93Mildly elevated creatine phosphokinase (HP:0008180)1.84321495
94Turricephaly (HP:0000262)1.83903883
95Spastic diplegia (HP:0001264)1.82079832
96Spinal cord lesions (HP:0100561)1.81960278
97Syringomyelia (HP:0003396)1.81960278
98Increased variability in muscle fiber diameter (HP:0003557)1.81553873
99Natal tooth (HP:0000695)1.80282668
100Camptodactyly of toe (HP:0001836)1.79869715
101Macrocytic anemia (HP:0001972)1.79279744
102Abnormality of the Achilles tendon (HP:0005109)1.76747642
103Short 5th finger (HP:0009237)1.76695231
104Lymphangioma (HP:0100764)1.76610392
105Pterygium (HP:0001059)1.75627590
106Abnormality of the tricuspid valve (HP:0001702)1.75594594
107Bowed forearm bones (HP:0003956)1.75199551
108Bowing of the arm (HP:0006488)1.75199551
109Aplasia/Hypoplasia of the clavicles (HP:0006710)1.74632255
110Abnormalities of placenta or umbilical cord (HP:0001194)1.74595002
111Mesomelia (HP:0003027)1.74571699
112Arterial tortuosity (HP:0005116)1.73759633
113Rectal prolapse (HP:0002035)1.73559988
114Abnormality of the 4th metacarpal (HP:0010012)1.73488671
115Mitral regurgitation (HP:0001653)1.72839089
116Joint laxity (HP:0001388)1.71732518
117Back pain (HP:0003418)1.70765255
118Wrist flexion contracture (HP:0001239)1.70489362
119Osteolytic defects of the hand bones (HP:0009699)1.70159507
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.70159507
121Follicular hyperkeratosis (HP:0007502)1.70060999
122Atresia of the external auditory canal (HP:0000413)1.69781539
123Long toe (HP:0010511)1.69196198
124Hypercalcemia (HP:0003072)1.68066532
125Abnormality of the umbilical cord (HP:0010881)1.66746509
126Congenital glaucoma (HP:0001087)1.65789891
127Radial bowing (HP:0002986)1.64795172
128Abnormal ossification of hand bones (HP:0005921)1.64618759
129Short middle phalanx of the 5th finger (HP:0004220)1.64538482
130Hyperacusis (HP:0010780)1.64325404
131Knee flexion contracture (HP:0006380)1.64303863
132Abnormality of the calcaneus (HP:0008364)1.63859082
133Preauricular skin tag (HP:0000384)1.61125550
134Concave nail (HP:0001598)1.60932666
135Unilateral renal agenesis (HP:0000122)1.60791650
136Abnormality of carpal bone ossification (HP:0006257)1.60721564
137Broad hallux (HP:0010055)1.60537096
138Pallor (HP:0000980)1.59953519
139Ragged-red muscle fibers (HP:0003200)1.59370196
140Thrombocytosis (HP:0001894)1.57200467
141Abnormal number of incisors (HP:0011064)1.56897469
142Abnormality of the 2nd finger (HP:0004100)1.55956043
143Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.55532282
144Increased density of long bones (HP:0006392)1.54684832
145Skin tags (HP:0010609)1.53222387
146Slender build (HP:0001533)1.52968844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.52540203
2TRIB33.28769504
3NME23.01145626
4IRAK32.89000180
5VRK22.86385846
6PKN22.82369828
7ERN12.42637340
8TTN2.33219485
9BUB12.32652896
10TGFBR12.26370113
11LATS22.22705485
12PAK42.09275199
13WEE12.06458667
14DDR22.05991540
15EPHB22.04973609
16RPS6KA41.98103848
17EEF2K1.91793160
18EPHA21.89583833
19MAP3K101.87719635
20TLK11.77226958
21TESK21.74573522
22BCKDK1.70222962
23LRRK21.69890759
24RPS6KB21.68717946
25SRPK11.66814308
26CDK71.63066029
27PDGFRA1.60818286
28ARAF1.55844441
29TGFBR21.53679522
30LATS11.51323324
31PAK21.45194657
32DYRK31.44145571
33TAF11.43464986
34TESK11.43449293
35PIM21.42959222
36FLT31.41493130
37SIK11.36995961
38PASK1.33919744
39PRPF4B1.30312541
40CDC71.27974077
41KDR1.27097776
42PBK1.25161335
43LIMK11.23144182
44FER1.23058513
45ILK1.19961432
46RIPK11.19283724
47MET1.15083603
48NTRK11.14971622
49MKNK11.14232587
50MAP3K81.11307509
51NEK21.11106536
52CDK121.10809155
53MAP2K31.08525139
54PTK61.06869936
55BRAF1.05974394
56MAPKAPK31.04423035
57NEK11.04422327
58STK161.04153060
59BMX1.01687442
60NEK91.00580038
61STK100.98463119
62STK38L0.94293649
63BRSK20.92862862
64PRKD30.92304295
65MAP3K110.90452731
66EIF2AK10.89543688
67AURKB0.88849233
68PTK20.87536467
69MYLK0.86133278
70SCYL20.85220220
71ERBB40.84867265
72MTOR0.84848110
73CDK60.84081847
74CDK80.83645566
75CDK40.82510203
76PLK10.80327834
77TTK0.79718738
78MAP3K30.79621496
79FGFR10.79463344
80BRSK10.79343122
81DYRK1B0.78850426
82LMTK20.76040571
83MOS0.70137017
84RPS6KA20.69106821
85MKNK20.68279439
86CDC42BPA0.66378787
87PAK10.65320166
88TIE10.64781264
89TAOK20.64328303
90ACVR1B0.64138880
91DAPK30.63289790
92IRAK20.62616310
93AURKA0.62357836
94ATR0.61925185
95STK30.58992843
96PRKG20.57014831
97DMPK0.56402336
98NME10.56181140
99MST1R0.55703752
100AKT20.55060478
101MAP2K20.54968609
102ERBB20.54284364
103MATK0.53881434
104DAPK10.51633248
105FGFR40.48747932
106ROCK10.46227267
107MAPK110.45781106
108MAPKAPK20.45259427
109MAPKAPK50.45187424
110STK40.40658882
111MAP3K60.39793240
112CHEK20.39096726
113ABL20.39039884
114MUSK0.38275783
115VRK10.38016198
116ROCK20.37744168
117RPS6KL10.37618000
118RPS6KC10.37618000
119PIM10.37114631
120CAMK2G0.36405912
121PRKCI0.35676314
122RPS6KA60.35606830
123PRKD20.34917913
124ICK0.32745564
125CDK90.31728211
126MELK0.31508183
127CHEK10.30574043

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.17366186
2DNA replication_Homo sapiens_hsa030303.13172204
3One carbon pool by folate_Homo sapiens_hsa006702.51794118
4Spliceosome_Homo sapiens_hsa030402.29240352
5Mismatch repair_Homo sapiens_hsa034302.24046824
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97610523
7Base excision repair_Homo sapiens_hsa034101.96155488
8Basal cell carcinoma_Homo sapiens_hsa052171.94702351
9RNA transport_Homo sapiens_hsa030131.91795567
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82347928
11Sulfur relay system_Homo sapiens_hsa041221.81691828
12Cell cycle_Homo sapiens_hsa041101.81526908
13Vitamin B6 metabolism_Homo sapiens_hsa007501.79532557
14ECM-receptor interaction_Homo sapiens_hsa045121.77807637
15Bladder cancer_Homo sapiens_hsa052191.77231833
16p53 signaling pathway_Homo sapiens_hsa041151.62676401
17Nucleotide excision repair_Homo sapiens_hsa034201.55165193
18Fructose and mannose metabolism_Homo sapiens_hsa000511.53270548
19RNA polymerase_Homo sapiens_hsa030201.50582667
20Other glycan degradation_Homo sapiens_hsa005111.49689936
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49237773
22Hippo signaling pathway_Homo sapiens_hsa043901.47988096
23Pyrimidine metabolism_Homo sapiens_hsa002401.45878343
24Small cell lung cancer_Homo sapiens_hsa052221.39066343
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.36499724
26Glutathione metabolism_Homo sapiens_hsa004801.34477328
27Biosynthesis of amino acids_Homo sapiens_hsa012301.33820177
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33806755
29Homologous recombination_Homo sapiens_hsa034401.32350133
30Focal adhesion_Homo sapiens_hsa045101.28464328
31Proteoglycans in cancer_Homo sapiens_hsa052051.28034612
32Hedgehog signaling pathway_Homo sapiens_hsa043401.27552578
33MicroRNAs in cancer_Homo sapiens_hsa052061.25036519
34TGF-beta signaling pathway_Homo sapiens_hsa043501.24861385
35Proteasome_Homo sapiens_hsa030501.22263256
36Thyroid cancer_Homo sapiens_hsa052161.18374268
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.17771036
38Selenocompound metabolism_Homo sapiens_hsa004501.16235499
39Prion diseases_Homo sapiens_hsa050201.13171332
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13075927
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.12962505
42Adherens junction_Homo sapiens_hsa045201.12879559
43Chronic myeloid leukemia_Homo sapiens_hsa052201.04279445
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03645586
45Carbon metabolism_Homo sapiens_hsa012001.01092050
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.99728024
47HTLV-I infection_Homo sapiens_hsa051660.97443140
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95983283
49Notch signaling pathway_Homo sapiens_hsa043300.95793357
50Vibrio cholerae infection_Homo sapiens_hsa051100.95668102
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95350345
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91158584
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90415483
54Pancreatic cancer_Homo sapiens_hsa052120.89911539
55Sulfur metabolism_Homo sapiens_hsa009200.88843832
56RNA degradation_Homo sapiens_hsa030180.87598439
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86555185
58mRNA surveillance pathway_Homo sapiens_hsa030150.86299419
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86269553
60Folate biosynthesis_Homo sapiens_hsa007900.85511400
61Protein digestion and absorption_Homo sapiens_hsa049740.85082702
62PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82869274
63Chemical carcinogenesis_Homo sapiens_hsa052040.81955130
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81756378
65Melanoma_Homo sapiens_hsa052180.80029283
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79296603
67Lysine degradation_Homo sapiens_hsa003100.78907503
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77583187
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77449166
70Pathways in cancer_Homo sapiens_hsa052000.77205287
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76266978
72Fatty acid degradation_Homo sapiens_hsa000710.76127009
73Acute myeloid leukemia_Homo sapiens_hsa052210.75626620
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.74862353
75Caffeine metabolism_Homo sapiens_hsa002320.73827881
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72613351
77Viral carcinogenesis_Homo sapiens_hsa052030.70639300
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69872313
79Pentose phosphate pathway_Homo sapiens_hsa000300.68822111
80Non-small cell lung cancer_Homo sapiens_hsa052230.68429391
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64919652
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64780763
83Galactose metabolism_Homo sapiens_hsa000520.64403747
84Lysosome_Homo sapiens_hsa041420.64030001
85Wnt signaling pathway_Homo sapiens_hsa043100.63065563
86Endometrial cancer_Homo sapiens_hsa052130.62283083
87Glioma_Homo sapiens_hsa052140.61378788
88Phenylalanine metabolism_Homo sapiens_hsa003600.60586412
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60327939
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59924770
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59901441
92Shigellosis_Homo sapiens_hsa051310.59558790
93Amoebiasis_Homo sapiens_hsa051460.59491243
94VEGF signaling pathway_Homo sapiens_hsa043700.59073186
95Tight junction_Homo sapiens_hsa045300.58903809
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58384707
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57899149
98HIF-1 signaling pathway_Homo sapiens_hsa040660.57027628
99Huntingtons disease_Homo sapiens_hsa050160.56004815
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55850730
101Fanconi anemia pathway_Homo sapiens_hsa034600.54923567
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54644242
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54618939
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54511946
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54380835
106Prostate cancer_Homo sapiens_hsa052150.54326667
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53833770
108Herpes simplex infection_Homo sapiens_hsa051680.53512070
109Arginine and proline metabolism_Homo sapiens_hsa003300.52337395
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51442288
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48810631
112Pyruvate metabolism_Homo sapiens_hsa006200.47936789
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.46392091
114Tyrosine metabolism_Homo sapiens_hsa003500.46390135
115Apoptosis_Homo sapiens_hsa042100.46135576
116Epstein-Barr virus infection_Homo sapiens_hsa051690.46087876
117Fatty acid elongation_Homo sapiens_hsa000620.45697648
118Viral myocarditis_Homo sapiens_hsa054160.45217208
119Colorectal cancer_Homo sapiens_hsa052100.45093281
120Systemic lupus erythematosus_Homo sapiens_hsa053220.44612201
121Arginine biosynthesis_Homo sapiens_hsa002200.43477974
122Renal cell carcinoma_Homo sapiens_hsa052110.42650677
123Purine metabolism_Homo sapiens_hsa002300.40699030
124Insulin signaling pathway_Homo sapiens_hsa049100.40525065
125N-Glycan biosynthesis_Homo sapiens_hsa005100.40339507
126Basal transcription factors_Homo sapiens_hsa030220.39502893
127Malaria_Homo sapiens_hsa051440.38907819
128AMPK signaling pathway_Homo sapiens_hsa041520.38214711

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