TRIQK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)4.49480235
2neuron cell-cell adhesion (GO:0007158)4.45331828
3vocalization behavior (GO:0071625)4.21186004
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.10551464
5neuronal action potential propagation (GO:0019227)4.01991249
6protein localization to synapse (GO:0035418)3.89155385
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.80821985
8cellular ketone body metabolic process (GO:0046950)3.80072568
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.77312795
10detection of calcium ion (GO:0005513)3.62750725
11platelet dense granule organization (GO:0060155)3.59190307
12regulation of hexokinase activity (GO:1903299)3.57145670
13regulation of glucokinase activity (GO:0033131)3.57145670
14neurotransmitter-gated ion channel clustering (GO:0072578)3.56194692
15regulation of synaptic vesicle exocytosis (GO:2000300)3.54952814
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49230112
17glutamate secretion (GO:0014047)3.48208005
18negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.45176390
19ketone body metabolic process (GO:1902224)3.44355532
20innervation (GO:0060384)3.39046630
21regulation of glutamate receptor signaling pathway (GO:1900449)3.38850954
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.37167936
23neuron-neuron synaptic transmission (GO:0007270)3.36144111
24exploration behavior (GO:0035640)3.31998966
25locomotory exploration behavior (GO:0035641)3.31846391
26positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28555809
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.25394436
28nonmotile primary cilium assembly (GO:0035058)3.24873814
29positive regulation of glycolytic process (GO:0045821)3.24842813
30synaptic vesicle maturation (GO:0016188)3.23951624
31negative regulation of dendrite morphogenesis (GO:0050774)3.22946308
32regulation of synaptic vesicle transport (GO:1902803)3.21875135
33regulation of vesicle fusion (GO:0031338)3.20391985
34synaptic transmission, glutamatergic (GO:0035249)3.20325188
35negative regulation of cation channel activity (GO:2001258)3.19999548
36postsynaptic membrane organization (GO:0001941)3.18698772
37neurotransmitter secretion (GO:0007269)3.14540103
38regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.13195923
39regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.13195923
40positive regulation of synapse maturation (GO:0090129)3.12197917
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.11329525
42presynaptic membrane assembly (GO:0097105)3.10941001
43epithelial cilium movement (GO:0003351)3.10191975
44glutamate receptor signaling pathway (GO:0007215)3.09585697
45regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.09358114
46regulation of respiratory system process (GO:0044065)3.09092349
47dendritic spine morphogenesis (GO:0060997)3.07599348
48striatum development (GO:0021756)3.04635931
49glycerophospholipid catabolic process (GO:0046475)3.02366386
50positive regulation of protein autophosphorylation (GO:0031954)3.01078532
51long-term synaptic potentiation (GO:0060291)2.99881208
52magnesium ion transport (GO:0015693)2.98662724
53response to histamine (GO:0034776)2.98591011
54synaptic transmission, dopaminergic (GO:0001963)2.96952210
55dendrite development (GO:0016358)2.96910756
56negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94974442
57regulation of synapse structural plasticity (GO:0051823)2.94482927
58negative regulation of dendrite development (GO:2000171)2.92950865
59intraciliary transport (GO:0042073)2.92728828
60behavioral fear response (GO:0001662)2.90184880
61behavioral defense response (GO:0002209)2.90184880
62positive regulation of vesicle fusion (GO:0031340)2.89582621
63insulin secretion (GO:0030073)2.86524797
64dopamine biosynthetic process (GO:0042416)2.86160973
65regulation of synaptic transmission, glutamatergic (GO:0051966)2.85644785
66regulation of long-term neuronal synaptic plasticity (GO:0048169)2.83629316
67cilium movement (GO:0003341)2.83483847
68startle response (GO:0001964)2.83401567
69synaptic vesicle endocytosis (GO:0048488)2.82861250
70long-term memory (GO:0007616)2.82553258
71synaptic vesicle docking involved in exocytosis (GO:0016081)2.81407188
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.81263011
73L-phenylalanine catabolic process (GO:0006559)2.81263011
74behavioral response to cocaine (GO:0048148)2.80204372
75regulation of excitatory postsynaptic membrane potential (GO:0060079)2.78230715
76neuron recognition (GO:0008038)2.78113548
77energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.77639712
78ATP hydrolysis coupled proton transport (GO:0015991)2.77639712
79regulation of neuronal synaptic plasticity (GO:0048168)2.77454059
80regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76878520
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76293043
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76226819
83neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.74653217
84fear response (GO:0042596)2.73578429
85regulation of synapse maturation (GO:0090128)2.73313165
86neurotransmitter transport (GO:0006836)2.73170520
87regulation of type B pancreatic cell apoptotic process (GO:2000674)2.73119423
88gamma-aminobutyric acid transport (GO:0015812)2.73118588
89regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.72575553
90presynaptic membrane organization (GO:0097090)2.72561028
91endocrine pancreas development (GO:0031018)2.71827574
92protein localization to cilium (GO:0061512)2.70969695
93negative regulation of calcium ion transmembrane transport (GO:1903170)2.70224914
94negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.70224914
95regulation of postsynaptic membrane potential (GO:0060078)2.69323882
96positive regulation of synapse assembly (GO:0051965)2.68696722
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.68638930
98layer formation in cerebral cortex (GO:0021819)2.68472257
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68194223
100synapse assembly (GO:0007416)2.67660641
101chaperone-mediated protein transport (GO:0072321)2.66985353
102mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66552482
103regulation of neurotransmitter uptake (GO:0051580)2.65998631
104regulation of cilium movement (GO:0003352)2.65792664
105protein prenylation (GO:0018342)2.64239346
106prenylation (GO:0097354)2.64239346
107dendritic spine organization (GO:0097061)2.64184454
108proline transport (GO:0015824)2.63776613
109epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63535923
110response to gravity (GO:0009629)2.62334683
111sleep (GO:0030431)2.61692931
112regulation of dopamine secretion (GO:0014059)2.61582314
113establishment of synaptic vesicle localization (GO:0097480)2.61359144
114synaptic vesicle transport (GO:0048489)2.61359144
115positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.60522421
116calcium-mediated signaling using intracellular calcium source (GO:0035584)2.60157062
117regulation of neurotransmitter secretion (GO:0046928)2.59989069
118regulation of protein kinase A signaling (GO:0010738)2.59766465
119transmission of nerve impulse (GO:0019226)2.59297176
120nitric oxide mediated signal transduction (GO:0007263)2.58785682
121positive regulation of membrane potential (GO:0045838)2.58740573
122regulation of neurotransmitter transport (GO:0051588)2.58730954
123neuronal action potential (GO:0019228)2.58387525
124regulation of respiratory gaseous exchange (GO:0043576)2.58103810
125embryonic retina morphogenesis in camera-type eye (GO:0060059)2.57048980
126nucleobase catabolic process (GO:0046113)2.55573672
127artery smooth muscle contraction (GO:0014824)2.55374662
128dopamine transport (GO:0015872)2.54784688
129auditory receptor cell differentiation (GO:0042491)2.54436210
130type B pancreatic cell development (GO:0003323)2.49847381
131prostate gland growth (GO:0060736)2.48656759
132cilium organization (GO:0044782)2.48523908
133tonic smooth muscle contraction (GO:0014820)2.47541806
134peptidyl-cysteine modification (GO:0018198)2.46735364
135cilium assembly (GO:0042384)2.46221773
136L-fucose catabolic process (GO:0042355)2.45991601
137fucose catabolic process (GO:0019317)2.45991601
138L-fucose metabolic process (GO:0042354)2.45991601
139vascular smooth muscle contraction (GO:0014829)2.44093831
140negative regulation of complement activation (GO:0045916)2.43064333
141auditory behavior (GO:0031223)2.39548703
142polyol catabolic process (GO:0046174)2.38646485
143reflex (GO:0060004)2.35614338
144negative regulation of protein activation cascade (GO:2000258)2.35434143
145glycosphingolipid biosynthetic process (GO:0006688)2.33764404
146erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.33698363
147L-phenylalanine metabolic process (GO:0006558)2.33698363
148water-soluble vitamin biosynthetic process (GO:0042364)2.33164077
149nephron epithelium morphogenesis (GO:0072088)2.30502686
150nephron tubule morphogenesis (GO:0072078)2.30502686
151phenylpropanoid metabolic process (GO:0009698)2.30113324
152negative regulation of hormone biosynthetic process (GO:0032353)2.29501708
153pancreas development (GO:0031016)2.28480261
154neurotransmitter uptake (GO:0001504)2.28161186
155regulation of male gonad development (GO:2000018)2.27855076
156axoneme assembly (GO:0035082)2.27076856
157bile acid biosynthetic process (GO:0006699)2.26782899
158protein neddylation (GO:0045116)2.25916697
159intra-Golgi vesicle-mediated transport (GO:0006891)2.25359736
160regulation of protein glycosylation (GO:0060049)2.25184466
161neuron fate determination (GO:0048664)2.24165856
162renal tubule morphogenesis (GO:0061333)2.23846804
163positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.21949510
164cilium morphogenesis (GO:0060271)2.20494415
165retinal metabolic process (GO:0042574)2.19927840
166zinc ion transport (GO:0006829)2.19814572
167limb bud formation (GO:0060174)2.18436039
168inner ear receptor cell differentiation (GO:0060113)2.17757229
169kidney morphogenesis (GO:0060993)2.14636301
170anterograde synaptic vesicle transport (GO:0048490)2.13647127
171sequestering of extracellular ligand from receptor (GO:0035581)2.13190057
172branched-chain amino acid catabolic process (GO:0009083)2.12575724
173regulation of integrin-mediated signaling pathway (GO:2001044)2.12473204
174detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.12425042
175behavioral response to nicotine (GO:0035095)2.10559763
176brain morphogenesis (GO:0048854)2.09863034
177positive regulation of peptide hormone secretion (GO:0090277)2.09611175
178response to pheromone (GO:0019236)2.09209996
179melanosome transport (GO:0032402)2.08956490
180xenobiotic catabolic process (GO:0042178)2.08397966
181macroautophagy (GO:0016236)2.08295111
182righting reflex (GO:0060013)2.07866632
183beta-amyloid metabolic process (GO:0050435)2.05565871
184positive regulation of peptide secretion (GO:0002793)2.04924275
185establishment of melanosome localization (GO:0032401)2.04876993
186heme transport (GO:0015886)2.04746918
187pyrimidine nucleobase catabolic process (GO:0006208)2.04577238
188cellular component assembly involved in morphogenesis (GO:0010927)2.04238584
189pigment granule transport (GO:0051904)2.04217002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.50218309
2GBX2_23144817_ChIP-Seq_PC3_Human3.88385771
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82481007
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75109325
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71141040
6TAF15_26573619_Chip-Seq_HEK293_Human2.63338189
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47267702
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.39805264
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38659511
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38019246
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37879502
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30459319
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30459319
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30086228
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28870029
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.19776136
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.16458225
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13520571
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12369298
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12109638
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11734087
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07584627
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07526272
24REST_21632747_ChIP-Seq_MESCs_Mouse2.04965573
25P300_19829295_ChIP-Seq_ESCs_Human2.00447023
26IGF1R_20145208_ChIP-Seq_DFB_Human1.99050190
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96886589
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92384153
29SMAD4_21799915_ChIP-Seq_A2780_Human1.88134405
30FUS_26573619_Chip-Seq_HEK293_Human1.87487937
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85193678
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.85163576
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.84939381
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80840379
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.74384854
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.72786831
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69091070
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68870038
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.68675478
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68144906
41FOXM1_26456572_ChIP-Seq_MCF-7_Human1.65111805
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64459284
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.63246389
44VDR_22108803_ChIP-Seq_LS180_Human1.61033800
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57582035
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.54869929
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49261343
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49261343
49RNF2_27304074_Chip-Seq_NSC_Mouse1.48740264
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.47710316
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47100740
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45801894
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45223680
54AR_25329375_ChIP-Seq_VCAP_Human1.43205112
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41591101
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.40093852
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.37705555
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36226174
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36108664
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35366359
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34990356
62HTT_18923047_ChIP-ChIP_STHdh_Human1.31759264
63AHR_22903824_ChIP-Seq_MCF-7_Human1.31617537
64AR_21572438_ChIP-Seq_LNCaP_Human1.31532693
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30883701
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30525276
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30404276
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29479151
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29404411
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28429982
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.28133526
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.28130128
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.27695285
74STAT3_23295773_ChIP-Seq_U87_Human1.26865654
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25763517
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24535465
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24518804
78ZNF274_21170338_ChIP-Seq_K562_Hela1.21428075
79TCF4_22108803_ChIP-Seq_LS180_Human1.21193120
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.20081092
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20039740
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19803538
83NANOG_19829295_ChIP-Seq_ESCs_Human1.18729554
84SOX2_19829295_ChIP-Seq_ESCs_Human1.18729554
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18600661
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.18150198
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17665234
88CDX2_22108803_ChIP-Seq_LS180_Human1.17084262
89JUN_21703547_ChIP-Seq_K562_Human1.16794397
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16554429
91RUNX2_22187159_ChIP-Seq_PCA_Human1.13158953
92BCAT_22108803_ChIP-Seq_LS180_Human1.12883807
93TP53_18474530_ChIP-ChIP_U2OS_Human1.12465206
94ER_23166858_ChIP-Seq_MCF-7_Human1.12081385
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.10686459
96EWS_26573619_Chip-Seq_HEK293_Human1.10421660
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10376691
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09929878
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.08881148
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08492023
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.07918714
102P53_22387025_ChIP-Seq_ESCs_Mouse1.07843551
103CJUN_26792858_Chip-Seq_BT549_Human1.06041704
104TCF4_23295773_ChIP-Seq_U87_Human1.05835096
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05267838
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04483321
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.04008681
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03393224
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03188532
110DROSHA_22980978_ChIP-Seq_HELA_Human1.03127333
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.02416352
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02379794
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01809634
114P300_18555785_Chip-Seq_ESCs_Mouse1.01686139
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.01678165
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01548884
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.01125659
118FLI1_21867929_ChIP-Seq_TH2_Mouse1.01057701
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00499969
120CBP_20019798_ChIP-Seq_JUKART_Human1.00499969
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99777585
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99576364
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99113675
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.98646145
125FOXA1_25552417_ChIP-Seq_VCAP_Human0.98580688
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98068874
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.97896902
128KDM2B_26808549_Chip-Seq_REH_Human0.97360351
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96995725
130SOX2_18555785_Chip-Seq_ESCs_Mouse0.95806982
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95042392
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95042392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.08619780
2MP0003880_abnormal_central_pattern3.90813036
3MP0004270_analgesia3.29377137
4MP0003635_abnormal_synaptic_transmissio3.13348460
5MP0001968_abnormal_touch/_nociception3.04880136
6MP0003195_calcinosis2.84001340
7MP0009745_abnormal_behavioral_response2.82931980
8MP0002736_abnormal_nociception_after2.75399335
9MP0002063_abnormal_learning/memory/cond2.68235324
10MP0002734_abnormal_mechanical_nocicepti2.62622848
11MP0002735_abnormal_chemical_nociception2.53483801
12MP0000569_abnormal_digit_pigmentation2.52017164
13MP0006276_abnormal_autonomic_nervous2.49410283
14MP0002572_abnormal_emotion/affect_behav2.46990040
15MP0002272_abnormal_nervous_system2.42175850
16MP0002064_seizures2.41936460
17MP0005646_abnormal_pituitary_gland2.37110971
18MP0001501_abnormal_sleep_pattern2.34291062
19MP0001529_abnormal_vocalization2.34054147
20MP0010386_abnormal_urinary_bladder2.26251648
21MP0002733_abnormal_thermal_nociception2.25083695
22MP0001188_hyperpigmentation2.20147537
23MP0009046_muscle_twitch2.19289867
24MP0002822_catalepsy2.14375151
25MP0001970_abnormal_pain_threshold2.12125794
26MP0002837_dystrophic_cardiac_calcinosis2.09824252
27MP0001486_abnormal_startle_reflex2.08628265
28MP0010678_abnormal_skin_adnexa2.00003961
29MP0001905_abnormal_dopamine_level1.99832724
30MP0002139_abnormal_hepatobiliary_system1.99306175
31MP0002067_abnormal_sensory_capabilities1.97707927
32MP0000383_abnormal_hair_follicle1.95678752
33MP0001984_abnormal_olfaction1.95289305
34MP0001986_abnormal_taste_sensitivity1.93334627
35MP0006292_abnormal_olfactory_placode1.87347037
36MP0005085_abnormal_gallbladder_physiolo1.81945684
37MP0003122_maternal_imprinting1.81878580
38MP0001440_abnormal_grooming_behavior1.79781081
39MP0003121_genomic_imprinting1.79639841
40MP0002557_abnormal_social/conspecific_i1.79156549
41MP0002184_abnormal_innervation1.77226984
42MP0002102_abnormal_ear_morphology1.76179726
43MP0005365_abnormal_bile_salt1.74086907
44MP0000778_abnormal_nervous_system1.73591502
45MP0008877_abnormal_DNA_methylation1.71303868
46MP0005423_abnormal_somatic_nervous1.70486318
47MP0005248_abnormal_Harderian_gland1.68373806
48MP0009780_abnormal_chondrocyte_physiolo1.68348081
49MP0004924_abnormal_behavior1.67364754
50MP0005386_behavior/neurological_phenoty1.67364754
51MP0006072_abnormal_retinal_apoptosis1.63785208
52MP0008875_abnormal_xenobiotic_pharmacok1.61224840
53MP0005645_abnormal_hypothalamus_physiol1.57898458
54MP0000013_abnormal_adipose_tissue1.51450277
55MP0003011_delayed_dark_adaptation1.48982954
56MP0000427_abnormal_hair_cycle1.47623244
57MP0002909_abnormal_adrenal_gland1.45720994
58MP0004885_abnormal_endolymph1.44471116
59MP0005220_abnormal_exocrine_pancreas1.36487646
60MP0003283_abnormal_digestive_organ1.36272876
61MP0010329_abnormal_lipoprotein_level1.33747373
62MP0004133_heterotaxia1.33721818
63MP0005379_endocrine/exocrine_gland_phen1.32493889
64MP0000955_abnormal_spinal_cord1.31427251
65MP0001502_abnormal_circadian_rhythm1.27302177
66MP0004215_abnormal_myocardial_fiber1.26979938
67MP0004811_abnormal_neuron_physiology1.25651962
68MP0004145_abnormal_muscle_electrophysio1.21747442
69MP0000631_abnormal_neuroendocrine_gland1.21678943
70MP0002882_abnormal_neuron_morphology1.20966027
71MP0002090_abnormal_vision1.20797295
72MP0008569_lethality_at_weaning1.20309665
73MP0002638_abnormal_pupillary_reflex1.18881365
74MP0005408_hypopigmentation1.18393047
75MP0005551_abnormal_eye_electrophysiolog1.16988362
76MP0003879_abnormal_hair_cell1.12867588
77MP0002066_abnormal_motor_capabilities/c1.12336275
78MP0004147_increased_porphyrin_level1.11886782
79MP0008872_abnormal_physiological_respon1.09464341
80MP0001963_abnormal_hearing_physiology1.09181678
81MP0006054_spinal_hemorrhage1.08714494
82MP0000462_abnormal_digestive_system1.07146732
83MP0002928_abnormal_bile_duct1.06980088
84MP0004858_abnormal_nervous_system1.04666931
85MP0005187_abnormal_penis_morphology1.03981926
86MP0010234_abnormal_vibrissa_follicle1.03598616
87MP0004142_abnormal_muscle_tone1.03511571
88MP0002163_abnormal_gland_morphology1.03369407
89MP0008775_abnormal_heart_ventricle1.02709447
90MP0001756_abnormal_urination1.02652289
91MP0005171_absent_coat_pigmentation1.02588403
92MP0003252_abnormal_bile_duct1.01893776
93MP0002876_abnormal_thyroid_physiology1.01596595
94MP0000639_abnormal_adrenal_gland1.01457878
95MP0003868_abnormal_feces_composition1.01091153
96MP0001664_abnormal_digestion1.00964913
97MP0004742_abnormal_vestibular_system0.98175576
98MP0003329_amyloid_beta_deposits0.96210417
99MP0000516_abnormal_urinary_system0.94492778
100MP0005367_renal/urinary_system_phenotyp0.94492778
101MP0005332_abnormal_amino_acid0.93621380
102MP0003633_abnormal_nervous_system0.93345155
103MP0001270_distended_abdomen0.93191490
104MP0000647_abnormal_sebaceous_gland0.92962417
105MP0004019_abnormal_vitamin_homeostasis0.92418439
106MP0005084_abnormal_gallbladder_morpholo0.89651996
107MP0002152_abnormal_brain_morphology0.89370350
108MP0005394_taste/olfaction_phenotype0.89004327
109MP0005499_abnormal_olfactory_system0.89004327
110MP0002752_abnormal_somatic_nervous0.88841973
111MP0005409_darkened_coat_color0.87308096
112MP0003787_abnormal_imprinting0.86211486
113MP0002078_abnormal_glucose_homeostasis0.85484660
114MP0002295_abnormal_pulmonary_circulatio0.83135271
115MP0001324_abnormal_eye_pigmentation0.82784274
116MP0001666_abnormal_nutrient_absorption0.82607932
117MP0002069_abnormal_eating/drinking_beha0.82540434
118MP0005253_abnormal_eye_physiology0.82368666
119MP0003631_nervous_system_phenotype0.82338869
120MP0004484_altered_response_of0.81735196
121MP0002229_neurodegeneration0.81198577
122MP0003942_abnormal_urinary_system0.80586276
123MP0005174_abnormal_tail_pigmentation0.80344385
124MP0009250_abnormal_appendicular_skeleto0.78699501
125MP0000751_myopathy0.77982790
126MP0004043_abnormal_pH_regulation0.77741872
127MP0002751_abnormal_autonomic_nervous0.77614804
128MP0003634_abnormal_glial_cell0.77455556
129MP0009379_abnormal_foot_pigmentation0.77263664
130MP0008789_abnormal_olfactory_epithelium0.76618795
131MP0005535_abnormal_body_temperature0.75868125
132MP0001485_abnormal_pinna_reflex0.74272492
133MP0004085_abnormal_heartbeat0.72406180
134MP0000026_abnormal_inner_ear0.72354365
135MP0000230_abnormal_systemic_arterial0.70584561
136MP0000372_irregular_coat_pigmentation0.68760533
137MP0002693_abnormal_pancreas_physiology0.66567925
138MP0000681_abnormal_thyroid_gland0.65149683
139MP0003183_abnormal_peptide_metabolism0.63839402
140MP0003123_paternal_imprinting0.62717568
141MP0000534_abnormal_ureter_morphology0.62464191
142MP0001944_abnormal_pancreas_morphology0.61629950
143MP0002234_abnormal_pharynx_morphology0.60306400
144MP0002938_white_spotting0.59559146

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.67347820
2Hypothermia (HP:0002045)4.89712352
3Myokymia (HP:0002411)4.64806580
4Atonic seizures (HP:0010819)4.39959491
5Visual hallucinations (HP:0002367)3.98710847
6Epileptic encephalopathy (HP:0200134)3.83809817
7Focal seizures (HP:0007359)3.73176652
8Febrile seizures (HP:0002373)3.61396120
9Gait imbalance (HP:0002141)3.52397631
10Hypoglycemic coma (HP:0001325)3.47042280
11Medial flaring of the eyebrow (HP:0010747)3.38139430
12Congenital primary aphakia (HP:0007707)3.36373640
13Drooling (HP:0002307)3.36333557
14Excessive salivation (HP:0003781)3.36333557
15Acute necrotizing encephalopathy (HP:0006965)3.22123908
16Absence seizures (HP:0002121)3.20130041
17Genital tract atresia (HP:0001827)3.13431026
18Nephrogenic diabetes insipidus (HP:0009806)3.09745136
19Pancreatic cysts (HP:0001737)3.04345938
20Hyperventilation (HP:0002883)3.00624955
21Limb dystonia (HP:0002451)2.99972447
22Abnormal mitochondria in muscle tissue (HP:0008316)2.96491167
23Large for gestational age (HP:0001520)2.96340456
24Hyperinsulinemic hypoglycemia (HP:0000825)2.94663410
25Ketoacidosis (HP:0001993)2.91823286
26Pheochromocytoma (HP:0002666)2.90577488
27Vaginal atresia (HP:0000148)2.89295360
28Abnormality of midbrain morphology (HP:0002418)2.89031465
29Molar tooth sign on MRI (HP:0002419)2.89031465
30Agitation (HP:0000713)2.85838517
31Dialeptic seizures (HP:0011146)2.79407189
32Anxiety (HP:0000739)2.78809948
33Renal cortical cysts (HP:0000803)2.77747860
34Generalized tonic-clonic seizures (HP:0002069)2.77075868
35Progressive macrocephaly (HP:0004481)2.76434227
36Median cleft lip (HP:0000161)2.73553486
37Abnormality of the renal cortex (HP:0011035)2.70605956
38Progressive cerebellar ataxia (HP:0002073)2.69687334
39Hypoglycemic seizures (HP:0002173)2.64485225
40Progressive inability to walk (HP:0002505)2.63760334
41Hepatocellular necrosis (HP:0001404)2.60054936
42Neuroendocrine neoplasm (HP:0100634)2.53899352
43Aplasia/Hypoplasia of the lens (HP:0008063)2.52925811
44Papillary thyroid carcinoma (HP:0002895)2.52717084
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.51450333
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.51450333
47Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45663464
48Thyroid carcinoma (HP:0002890)2.43975776
49Polyphagia (HP:0002591)2.43626926
50Acute encephalopathy (HP:0006846)2.43076139
51Mitochondrial inheritance (HP:0001427)2.39032693
52Tubulointerstitial nephritis (HP:0001970)2.39020473
53Nephronophthisis (HP:0000090)2.38701197
54Megalencephaly (HP:0001355)2.37098798
55Hyperglycemia (HP:0003074)2.35299664
56Methylmalonic acidemia (HP:0002912)2.34596166
57Intestinal atresia (HP:0011100)2.31071426
58Abnormality of salivation (HP:0100755)2.29468304
59Chronic hepatic failure (HP:0100626)2.29080500
60Bifid tongue (HP:0010297)2.28612642
61Pancreatic fibrosis (HP:0100732)2.28100575
62Broad-based gait (HP:0002136)2.26964704
63Abnormality of the renal medulla (HP:0100957)2.25603351
64Poor coordination (HP:0002370)2.23997618
65Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21492504
66Abnormality of endocrine pancreas physiology (HP:0012093)2.21302675
67Abnormality of the pancreatic islet cells (HP:0006476)2.21302675
68Aplasia/Hypoplasia of the tongue (HP:0010295)2.20789938
69Amblyopia (HP:0000646)2.19531859
70Inability to walk (HP:0002540)2.19153715
71Retinal dysplasia (HP:0007973)2.17585675
72Arthropathy (HP:0003040)2.15656211
73Ketosis (HP:0001946)2.15582555
74Impaired pain sensation (HP:0007328)2.13548647
75Abnormality of pain sensation (HP:0010832)2.13548647
76Abnormal hair whorl (HP:0010721)2.12438967
77Postural tremor (HP:0002174)2.11187304
78Specific learning disability (HP:0001328)2.09396623
79Abnormality of the corticospinal tract (HP:0002492)2.09346926
80Abnormal pancreas size (HP:0012094)2.09286994
81Cystic liver disease (HP:0006706)2.08885831
82Disproportionate short-trunk short stature (HP:0003521)2.08285609
83Mutism (HP:0002300)2.07538892
84Poor suck (HP:0002033)2.07454919
85Postaxial hand polydactyly (HP:0001162)2.07167837
86Abnormality of calcium-phosphate metabolism (HP:0100530)2.06373431
87Pancreatic islet-cell hyperplasia (HP:0004510)2.05675635
88Delayed gross motor development (HP:0002194)2.05399817
89Proximal tubulopathy (HP:0000114)2.01876655
90Absent speech (HP:0001344)2.00191445
91Action tremor (HP:0002345)1.99644313
92Abnormality of methionine metabolism (HP:0010901)1.98309324
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.98167607
94Absent/shortened dynein arms (HP:0200106)1.98167607
95Short tibia (HP:0005736)1.97890175
96Broad foot (HP:0001769)1.97203511
97Type II lissencephaly (HP:0007260)1.96487033
98Abnormality of vitamin B metabolism (HP:0004340)1.96389710
99Furrowed tongue (HP:0000221)1.96211359
100Epileptiform EEG discharges (HP:0011182)1.95924117
101Male pseudohermaphroditism (HP:0000037)1.95138872
102Adrenal hypoplasia (HP:0000835)1.94713398
103Failure to thrive in infancy (HP:0001531)1.94482690
104Depression (HP:0000716)1.94452707
105Restlessness (HP:0000711)1.93699555
106True hermaphroditism (HP:0010459)1.93675094
107Aplasia/Hypoplasia of the tibia (HP:0005772)1.92947444
108Growth hormone excess (HP:0000845)1.92866289
109Optic disc pallor (HP:0000543)1.91265206
110Metaphyseal dysplasia (HP:0100255)1.90961907
111Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90457813
112Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90457813
113Truncal ataxia (HP:0002078)1.90223893
114Abnormal ciliary motility (HP:0012262)1.89916464
115Hepatoblastoma (HP:0002884)1.89702235
116Neoplasm of the thyroid gland (HP:0100031)1.87621977
117Biliary tract neoplasm (HP:0100574)1.87196105
118Submucous cleft hard palate (HP:0000176)1.85639989
119Abnormal biliary tract morphology (HP:0012440)1.85463345
120Hemiparesis (HP:0001269)1.83364297
121Increased CSF lactate (HP:0002490)1.83168926
122Narrow nasal bridge (HP:0000446)1.83159675
123EEG with generalized epileptiform discharges (HP:0011198)1.83137312
124Widely spaced teeth (HP:0000687)1.82969069
125Protruding tongue (HP:0010808)1.82645721
126Hypomagnesemia (HP:0002917)1.82110891
127Hypoventilation (HP:0002791)1.81621976
128Symptomatic seizures (HP:0011145)1.81600310
129Psychosis (HP:0000709)1.80859235
130Abnormal respiratory motile cilium physiology (HP:0012261)1.79694353
131Hyperkalemia (HP:0002153)1.78933947
132Vascular calcification (HP:0004934)1.78658799
133Abnormality of vitamin metabolism (HP:0100508)1.78517202
134Hepatic necrosis (HP:0002605)1.77492495
135Abnormal biliary tract physiology (HP:0012439)1.75917910
136Bile duct proliferation (HP:0001408)1.75917910
137Short foot (HP:0001773)1.75878507
138Testicular neoplasm (HP:0010788)1.75778400
139Diplopia (HP:0000651)1.75709954
140Abnormality of binocular vision (HP:0011514)1.75709954
141Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73088839
142Leukodystrophy (HP:0002415)1.72664618
143Vascular tortuosity (HP:0004948)1.71942519
144Generalized myoclonic seizures (HP:0002123)1.71736931
145Dysmetria (HP:0001310)1.71565395
146Arterial tortuosity (HP:0005116)1.71130441
147Thyroid-stimulating hormone excess (HP:0002925)1.70180969
148Patchy hypopigmentation of hair (HP:0011365)1.70148400
149Esotropia (HP:0000565)1.69924291
150Neoplasm of the adrenal cortex (HP:0100641)1.68740422
151Sex reversal (HP:0012245)1.68297134
152Abnormal sex determination (HP:0012244)1.68297134
153Epidermoid cyst (HP:0200040)1.68075918
154Torticollis (HP:0000473)1.67955139
155Neoplasm of the adrenal gland (HP:0100631)1.67709597
156Abolished electroretinogram (ERG) (HP:0000550)1.66903334
157Glycosuria (HP:0003076)1.66459876
158Abnormality of urine glucose concentration (HP:0011016)1.66459876
159X-linked dominant inheritance (HP:0001423)1.66229126
160Stereotypic behavior (HP:0000733)1.65701776
161Abnormal respiratory epithelium morphology (HP:0012253)1.65477490
162Abnormal respiratory motile cilium morphology (HP:0005938)1.65477490
163Hypsarrhythmia (HP:0002521)1.65027814
164Focal dystonia (HP:0004373)1.64030529
165Poor eye contact (HP:0000817)1.61091139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.60693456
2MAP3K124.36741804
3CASK4.04285794
4NTRK33.51861600
5EPHA42.89684065
6MAP3K92.72242532
7MAP2K72.64502502
8ARAF2.60262702
9MAP4K22.53187713
10GRK52.44794392
11ERBB32.37463202
12MAP3K42.27598613
13ACVR1B2.12362552
14PINK12.11486603
15PLK22.10883586
16MAP3K22.07663626
17CDK192.00240665
18STK391.93902458
19FGFR21.92479626
20TRIM281.89779786
21CDK81.89678831
22KSR21.83560602
23MAP2K41.76427499
24MINK11.75733111
25MUSK1.74987843
26MAPK131.66637604
27GRK11.63593758
28STK38L1.52587714
29MARK11.40229254
30PAK31.39955852
31RIPK41.36059142
32BRAF1.35925590
33NUAK11.32511313
34NTRK11.32187867
35WNK31.30986620
36STK31.27762858
37OXSR11.25635300
38CAMKK21.22687557
39MAP3K131.22486624
40ADRBK21.19963244
41BMPR21.13946540
42PRKD31.13692323
43TRPM71.13107296
44CSNK1G11.11804329
45PTK2B1.09461579
46BRSK21.08708847
47TNIK1.07891831
48NTRK21.06690888
49AKT31.04799864
50LATS21.04595481
51CAMK2A1.04541783
52INSRR1.03408217
53MYLK1.02605363
54DAPK11.00487816
55SGK21.00442912
56CSNK1G30.97467248
57TAOK30.96352513
58CDK50.95877753
59SGK2230.94321482
60SGK4940.94321482
61YES10.94096975
62NME10.91752797
63PRKCE0.90335954
64MAP3K60.89925309
65DAPK20.89917121
66EIF2AK30.89148586
67PRKCG0.87816568
68BMPR1B0.87617434
69MAPKAPK30.86617079
70LMTK20.86155789
71LATS10.84232121
72MAP3K10.84200941
73CAMK2D0.82563562
74KSR10.82356209
75RPS6KA20.82269007
76HIPK20.79380428
77PHKG10.77753483
78PHKG20.77753483
79CAMK2B0.75385926
80MOS0.74044273
81UHMK10.72950050
82RET0.72675885
83ERBB40.72412643
84MAPKAPK50.72398324
85PNCK0.71933144
86FER0.71078395
87MET0.70640830
88PDK30.70074994
89PDK40.70074994
90FES0.69041486
91STK160.68717556
92MKNK10.67917428
93CSNK1G20.67640635
94PAK60.66663190
95ILK0.66352691
96MAP2K10.65951353
97LIMK10.65522087
98EPHA30.65054484
99CAMK10.62222944
100CCNB10.62161304
101PRKCH0.62157712
102RAF10.60966257
103PLK30.59832564
104ADRBK10.58405820
105MKNK20.58160502
106FGFR30.57817732
107DYRK1A0.57537040
108SIK30.57279061
109CSNK1A1L0.55596696
110PDK10.53816903
111PRKG10.53088609
112PDPK10.52906025
113MARK20.52324715
114CDK140.51808875
115PRPF4B0.48567480
116BCKDK0.48401955
117CDK180.47975426
118MAPK150.47817867
119RPS6KA60.47786396
120FGR0.46103798
121DYRK20.45843538
122MST40.45432004
123SGK10.45414265
124MAP2K20.45210410
125PIK3CA0.45059169
126CSNK1A10.44946054
127PRKAA10.44324240
128EIF2AK10.43554469
129GRK70.43328492
130WNK10.43115765
131PRKACA0.43107166
132ERBB20.41856562
133CDK150.41684616
134PRKAA20.40352249
135FGFR10.40284137
136CAMKK10.40277483
137WNK40.39924256
138BCR0.39832855
139WEE10.39153815
140PASK0.38835837
141TGFBR10.38445708
142NLK0.37333445
143ROCK10.36345030
144FLT30.35325022
145PKN20.34720869
146BMX0.34630457
147PRKACB0.33948130
148PRKCZ0.33912339

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.42956793
2Synaptic vesicle cycle_Homo sapiens_hsa047213.08467658
3Circadian entrainment_Homo sapiens_hsa047132.58307332
4Oxidative phosphorylation_Homo sapiens_hsa001902.53780349
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53285385
6Butanoate metabolism_Homo sapiens_hsa006502.50951937
7GABAergic synapse_Homo sapiens_hsa047272.44932971
8Collecting duct acid secretion_Homo sapiens_hsa049662.42487770
9Olfactory transduction_Homo sapiens_hsa047402.36123265
10Amphetamine addiction_Homo sapiens_hsa050312.33861672
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.23992062
12Long-term potentiation_Homo sapiens_hsa047202.21719963
13Morphine addiction_Homo sapiens_hsa050322.18407995
14Insulin secretion_Homo sapiens_hsa049112.17380763
15Dopaminergic synapse_Homo sapiens_hsa047282.15568522
16Taste transduction_Homo sapiens_hsa047422.11651498
17Glutamatergic synapse_Homo sapiens_hsa047242.10734418
18Serotonergic synapse_Homo sapiens_hsa047262.01459205
19Parkinsons disease_Homo sapiens_hsa050122.00680545
20Alzheimers disease_Homo sapiens_hsa050101.97098894
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95835414
22Cholinergic synapse_Homo sapiens_hsa047251.82762340
23Propanoate metabolism_Homo sapiens_hsa006401.78249176
24Vibrio cholerae infection_Homo sapiens_hsa051101.77060904
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74582964
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66069246
27Cocaine addiction_Homo sapiens_hsa050301.65031177
28Salivary secretion_Homo sapiens_hsa049701.62589420
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62469942
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61245205
31Renin secretion_Homo sapiens_hsa049241.61075272
32Long-term depression_Homo sapiens_hsa047301.57908176
33Nitrogen metabolism_Homo sapiens_hsa009101.50785192
34Cardiac muscle contraction_Homo sapiens_hsa042601.48581918
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46301853
36Peroxisome_Homo sapiens_hsa041461.45333581
37Huntingtons disease_Homo sapiens_hsa050161.42812566
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41609217
39Gastric acid secretion_Homo sapiens_hsa049711.38649072
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35797706
41Steroid biosynthesis_Homo sapiens_hsa001001.34287700
42Calcium signaling pathway_Homo sapiens_hsa040201.33543109
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33238797
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32655003
45Fatty acid elongation_Homo sapiens_hsa000621.29449188
46Caffeine metabolism_Homo sapiens_hsa002321.26944886
47Oxytocin signaling pathway_Homo sapiens_hsa049211.24740960
48GnRH signaling pathway_Homo sapiens_hsa049121.24305322
49beta-Alanine metabolism_Homo sapiens_hsa004101.22386786
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20264951
51Chemical carcinogenesis_Homo sapiens_hsa052041.17605623
52Phototransduction_Homo sapiens_hsa047441.16541729
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.16178982
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12749567
55Selenocompound metabolism_Homo sapiens_hsa004501.12551320
56Tryptophan metabolism_Homo sapiens_hsa003801.11566083
57Retinol metabolism_Homo sapiens_hsa008301.08930192
58Vitamin B6 metabolism_Homo sapiens_hsa007501.08269004
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05951977
60Fatty acid degradation_Homo sapiens_hsa000711.05899795
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04959970
62Vascular smooth muscle contraction_Homo sapiens_hsa042701.04931796
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03583359
64cAMP signaling pathway_Homo sapiens_hsa040241.02949880
65Linoleic acid metabolism_Homo sapiens_hsa005911.01247938
66Protein export_Homo sapiens_hsa030600.99386134
67Mineral absorption_Homo sapiens_hsa049780.99212363
68Rheumatoid arthritis_Homo sapiens_hsa053230.98642224
69Gap junction_Homo sapiens_hsa045400.97831990
70Sphingolipid metabolism_Homo sapiens_hsa006000.95562928
71Fatty acid metabolism_Homo sapiens_hsa012120.95498397
72Estrogen signaling pathway_Homo sapiens_hsa049150.94188389
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93540342
74Circadian rhythm_Homo sapiens_hsa047100.93373778
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91050697
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.90527463
77Histidine metabolism_Homo sapiens_hsa003400.89671780
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88612897
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88581385
80Melanogenesis_Homo sapiens_hsa049160.87233070
81ABC transporters_Homo sapiens_hsa020100.87115573
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84982639
83Glucagon signaling pathway_Homo sapiens_hsa049220.82199644
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82159465
85Complement and coagulation cascades_Homo sapiens_hsa046100.82045622
86Bile secretion_Homo sapiens_hsa049760.81080329
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80870110
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80668195
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78921316
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77380494
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76923985
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76907828
93Pancreatic secretion_Homo sapiens_hsa049720.76546467
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75652128
95ErbB signaling pathway_Homo sapiens_hsa040120.75228704
96Thyroid hormone synthesis_Homo sapiens_hsa049180.74483618
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74018098
98Axon guidance_Homo sapiens_hsa043600.72050630
99Starch and sucrose metabolism_Homo sapiens_hsa005000.72013653
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70111012
101Oocyte meiosis_Homo sapiens_hsa041140.68063635
102Arachidonic acid metabolism_Homo sapiens_hsa005900.67003588
103MAPK signaling pathway_Homo sapiens_hsa040100.66531366
104Ovarian steroidogenesis_Homo sapiens_hsa049130.66444509
105Type I diabetes mellitus_Homo sapiens_hsa049400.66431115
106Folate biosynthesis_Homo sapiens_hsa007900.66188441
107Choline metabolism in cancer_Homo sapiens_hsa052310.65810967
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61886396
109Sulfur metabolism_Homo sapiens_hsa009200.61813740
110Dorso-ventral axis formation_Homo sapiens_hsa043200.61774308
111Type II diabetes mellitus_Homo sapiens_hsa049300.59648232
112Glioma_Homo sapiens_hsa052140.59430370
113Tyrosine metabolism_Homo sapiens_hsa003500.58175397
114Ras signaling pathway_Homo sapiens_hsa040140.58151412
115TGF-beta signaling pathway_Homo sapiens_hsa043500.58041044
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56715165
117Basal transcription factors_Homo sapiens_hsa030220.55983263
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53958351
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51601943
120Glutathione metabolism_Homo sapiens_hsa004800.51378625
121Dilated cardiomyopathy_Homo sapiens_hsa054140.50580653
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49996345
123Metabolic pathways_Homo sapiens_hsa011000.48962556
124Arginine and proline metabolism_Homo sapiens_hsa003300.48879274
125PPAR signaling pathway_Homo sapiens_hsa033200.48647292
126Alcoholism_Homo sapiens_hsa050340.48536772
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45629531
128Hedgehog signaling pathway_Homo sapiens_hsa043400.45387520
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.45184468
130Prolactin signaling pathway_Homo sapiens_hsa049170.44738650
131Fat digestion and absorption_Homo sapiens_hsa049750.42803855
132Colorectal cancer_Homo sapiens_hsa052100.42692431
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41969282
134Glycerolipid metabolism_Homo sapiens_hsa005610.41550789
135Melanoma_Homo sapiens_hsa052180.40175639
136Wnt signaling pathway_Homo sapiens_hsa043100.38574839
137Rap1 signaling pathway_Homo sapiens_hsa040150.37867913
138African trypanosomiasis_Homo sapiens_hsa051430.36019209
139Phagosome_Homo sapiens_hsa041450.34343133
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.34273163
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33778058
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33460098
143Renal cell carcinoma_Homo sapiens_hsa052110.32782261
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30384796
145Regulation of autophagy_Homo sapiens_hsa041400.30099573
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.28846304
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27234841
148Ether lipid metabolism_Homo sapiens_hsa005650.27083823
149Pyruvate metabolism_Homo sapiens_hsa006200.26824767
150Prion diseases_Homo sapiens_hsa050200.24574824
151Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23483245

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