TRIT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.63992951
2nuclear pore complex assembly (GO:0051292)4.62083433
3DNA unwinding involved in DNA replication (GO:0006268)4.42551020
4nuclear pore organization (GO:0006999)4.31201949
5IMP biosynthetic process (GO:0006188)4.17774206
6purine nucleobase biosynthetic process (GO:0009113)4.07867346
7folic acid-containing compound biosynthetic process (GO:0009396)4.01935515
8nucleobase biosynthetic process (GO:0046112)4.01277442
9maturation of SSU-rRNA (GO:0030490)3.89519782
10DNA replication initiation (GO:0006270)3.74739011
11mitotic sister chromatid segregation (GO:0000070)3.66660180
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66234051
13sister chromatid segregation (GO:0000819)3.59259140
14IMP metabolic process (GO:0046040)3.58615444
15folic acid metabolic process (GO:0046655)3.56631504
16establishment of integrated proviral latency (GO:0075713)3.54625947
17synapsis (GO:0007129)3.52315800
18histone exchange (GO:0043486)3.44903983
19formation of translation preinitiation complex (GO:0001731)3.44741021
20pore complex assembly (GO:0046931)3.43366141
21metaphase plate congression (GO:0051310)3.33248365
22DNA topological change (GO:0006265)3.32275506
23DNA double-strand break processing (GO:0000729)3.31859942
24non-recombinational repair (GO:0000726)3.31231380
25double-strand break repair via nonhomologous end joining (GO:0006303)3.31231380
26mitotic chromosome condensation (GO:0007076)3.30573043
27translational termination (GO:0006415)3.28289325
28tRNA aminoacylation for protein translation (GO:0006418)3.26988945
29viral transcription (GO:0019083)3.26627444
30telomere maintenance via recombination (GO:0000722)3.23102173
31tetrahydrofolate metabolic process (GO:0046653)3.20721527
32tRNA aminoacylation (GO:0043039)3.12672945
33amino acid activation (GO:0043038)3.12672945
34UTP biosynthetic process (GO:0006228)3.12500602
35GTP biosynthetic process (GO:0006183)3.12125072
36DNA strand elongation involved in DNA replication (GO:0006271)3.11207648
37nucleotide-excision repair, DNA gap filling (GO:0006297)3.07885629
38somatic hypermutation of immunoglobulin genes (GO:0016446)3.07579908
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07579908
40pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.07211352
41negative regulation of mitotic sister chromatid separation (GO:2000816)3.06984324
42negative regulation of sister chromatid segregation (GO:0033046)3.06984324
43negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06984324
44negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06984324
45negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06984324
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06960589
47regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06662309
48regulation of mitotic spindle checkpoint (GO:1903504)3.06662309
49CTP metabolic process (GO:0046036)3.06565313
50CTP biosynthetic process (GO:0006241)3.06565313
51mitotic spindle checkpoint (GO:0071174)3.06290298
52DNA replication checkpoint (GO:0000076)3.06141347
53negative regulation of RNA splicing (GO:0033119)3.05272089
54negative regulation of chromosome segregation (GO:0051985)3.05095871
55ribosomal large subunit biogenesis (GO:0042273)3.04924968
56kinetochore organization (GO:0051383)3.04893079
57pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.02385529
58spindle checkpoint (GO:0031577)3.02319672
59pteridine-containing compound biosynthetic process (GO:0042559)3.01480566
60ribonucleoprotein complex biogenesis (GO:0022613)3.01106782
61resolution of meiotic recombination intermediates (GO:0000712)3.01003188
62ribosomal small subunit biogenesis (GO:0042274)3.00117797
63viral mRNA export from host cell nucleus (GO:0046784)2.99366098
64ribosome biogenesis (GO:0042254)2.98884989
65glycine metabolic process (GO:0006544)2.97375125
66DNA strand elongation (GO:0022616)2.97369470
67histone mRNA metabolic process (GO:0008334)2.95850511
68protein localization to chromosome, centromeric region (GO:0071459)2.95828460
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95095987
70folic acid-containing compound metabolic process (GO:0006760)2.94281687
71ATP synthesis coupled proton transport (GO:0015986)2.93652348
72energy coupled proton transport, down electrochemical gradient (GO:0015985)2.93652348
73spliceosomal snRNP assembly (GO:0000387)2.92784786
74translational elongation (GO:0006414)2.92752486
75mitotic spindle assembly checkpoint (GO:0007094)2.92608486
76transcription elongation from RNA polymerase I promoter (GO:0006362)2.92090946
77pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.91527940
78regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91417278
79regulation of translational fidelity (GO:0006450)2.91279608
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90924542
81translational initiation (GO:0006413)2.90367416
82replication fork processing (GO:0031297)2.89570506
83mRNA splice site selection (GO:0006376)2.89370765
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89012021
85spindle assembly checkpoint (GO:0071173)2.88916184
86regulation of helicase activity (GO:0051095)2.88237554
87pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.87828802
88DNA catabolic process, exonucleolytic (GO:0000738)2.87597065
89UTP metabolic process (GO:0046051)2.86216431
90ribosome assembly (GO:0042255)2.86046321
91negative regulation of DNA recombination (GO:0045910)2.85719179
92establishment of chromosome localization (GO:0051303)2.85409579
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85401570
94SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85170063
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84351155
96regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84351155
97nuclear envelope disassembly (GO:0051081)2.83720738
98membrane disassembly (GO:0030397)2.83720738
99mismatch repair (GO:0006298)2.82884480
100regulation of sister chromatid segregation (GO:0033045)2.82742133
101regulation of mitotic sister chromatid separation (GO:0010965)2.82742133
102regulation of mitotic sister chromatid segregation (GO:0033047)2.82742133
103regulation of chromosome segregation (GO:0051983)2.82376490
104negative regulation of mRNA processing (GO:0050686)2.82140139
105regulation of centrosome cycle (GO:0046605)2.80742858
106guanosine-containing compound biosynthetic process (GO:1901070)2.79901319
107cotranslational protein targeting to membrane (GO:0006613)2.78758580
108DNA duplex unwinding (GO:0032508)2.78610698
109nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.76938133
110protein targeting to ER (GO:0045047)2.75717254
111maturation of 5.8S rRNA (GO:0000460)2.74905845
112proteasome assembly (GO:0043248)2.74802106
113DNA geometric change (GO:0032392)2.74422128
114mitotic metaphase plate congression (GO:0007080)2.74280292
115DNA damage response, detection of DNA damage (GO:0042769)2.74071382
116rRNA processing (GO:0006364)2.72849358
117rRNA modification (GO:0000154)2.71597057
118termination of RNA polymerase I transcription (GO:0006363)2.69103294
119CENP-A containing nucleosome assembly (GO:0034080)2.68152288
120erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.65809252
121L-phenylalanine catabolic process (GO:0006559)2.65809252
122pteridine-containing compound metabolic process (GO:0042558)2.64033635
123chromatin remodeling at centromere (GO:0031055)2.63558207
124pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.62797791
125telomere maintenance via telomere lengthening (GO:0010833)2.61960143
126mitotic nuclear envelope disassembly (GO:0007077)2.61918601
127spliceosomal tri-snRNP complex assembly (GO:0000244)2.61899764
128protein localization to kinetochore (GO:0034501)2.61224527
129methionine biosynthetic process (GO:0009086)2.60592415
130rRNA metabolic process (GO:0016072)2.60357801
131serine family amino acid biosynthetic process (GO:0009070)2.59094635
132protein localization to endoplasmic reticulum (GO:0070972)2.58617890
133establishment of protein localization to mitochondrial membrane (GO:0090151)2.58585586
134DNA replication-independent nucleosome assembly (GO:0006336)2.58139839
135DNA replication-independent nucleosome organization (GO:0034724)2.58139839
136establishment of protein localization to endoplasmic reticulum (GO:0072599)2.57711453
137termination of RNA polymerase II transcription (GO:0006369)2.56130427
138positive regulation of SMAD protein import into nucleus (GO:0060391)2.55757877
139sulfur amino acid biosynthetic process (GO:0000097)2.54962376
140regulation of nuclear cell cycle DNA replication (GO:0033262)2.54853290
141tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54240234
142RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54240234
143translation (GO:0006412)2.53589941
144telomere maintenance via semi-conservative replication (GO:0032201)2.53396370
145methionine metabolic process (GO:0006555)2.53015396
146DNA synthesis involved in DNA repair (GO:0000731)2.52824688
147telomere maintenance (GO:0000723)2.52104954
148mitotic recombination (GO:0006312)2.51891538
149regulation of centriole replication (GO:0046599)2.51468628
150cellular protein complex disassembly (GO:0043624)2.51399959
151attachment of spindle microtubules to kinetochore (GO:0008608)2.50851600
152somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.50772140
153isotype switching (GO:0045190)2.50772140
154somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.50772140
155snRNA processing (GO:0016180)2.50356455
156pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.49650132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.72978765
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.36057430
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42940518
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30213786
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.06908777
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96202207
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94792167
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89241232
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.76928668
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.73479029
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71280838
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.70644867
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66436143
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61260947
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60653523
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53067942
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48993876
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43364352
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36427543
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27555788
21VDR_23849224_ChIP-Seq_CD4+_Human2.23813260
22* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21141290
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20038542
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14234005
25XRN2_22483619_ChIP-Seq_HELA_Human2.13282463
26FOXP3_21729870_ChIP-Seq_TREG_Human2.10953882
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.10807431
28DCP1A_22483619_ChIP-Seq_HELA_Human2.09670958
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.08951929
30ELK1_19687146_ChIP-ChIP_HELA_Human2.08771296
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06563780
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05863155
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00425325
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99184949
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89915530
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86570711
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85529677
38CIITA_25753668_ChIP-Seq_RAJI_Human1.82798894
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81748488
40* GABP_19822575_ChIP-Seq_HepG2_Human1.80806697
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78282550
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77319728
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.75752877
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75585032
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74348107
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.73660530
47* TTF2_22483619_ChIP-Seq_HELA_Human1.71245890
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69096516
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66920343
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.66562636
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.64467368
52GATA1_22025678_ChIP-Seq_K562_Human1.61114851
53* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61011297
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.57598661
55EWS_26573619_Chip-Seq_HEK293_Human1.57180324
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54509712
57KDM5A_27292631_Chip-Seq_BREAST_Human1.49547238
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47172137
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44331002
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.43263871
61FUS_26573619_Chip-Seq_HEK293_Human1.43221746
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42191775
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37962816
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35590528
65ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35408489
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35107019
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34130941
68AR_21909140_ChIP-Seq_LNCAP_Human1.33184862
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27100230
70MYC_22102868_ChIP-Seq_BL_Human1.24887795
71TFEB_21752829_ChIP-Seq_HELA_Human1.24853249
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24691438
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24422734
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23232592
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21551273
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21378422
77ZNF274_21170338_ChIP-Seq_K562_Hela1.20831995
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19464983
79* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18989931
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17498901
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.13747377
82* SOX2_16153702_ChIP-ChIP_HESCs_Human1.10852258
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09740703
84RXR_22158963_ChIP-Seq_LIVER_Mouse1.08355198
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07929824
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07620789
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06820225
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06804646
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06159503
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05014712
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01811323
92* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00955173
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00852242
94TAF15_26573619_Chip-Seq_HEK293_Human0.97464742
95ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96998602
96* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96448606
97PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96344394
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96214852
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95460042
100* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95420129
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94818701
102IRF1_19129219_ChIP-ChIP_H3396_Human0.92887753
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92027401
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90050794
105POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90046305
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.89802656
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.89359627
108MYC_18940864_ChIP-ChIP_HL60_Human0.88287513
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87267851
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86435954
111TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83953018
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82716712
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81344353
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80034674
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79912056
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78926182
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.77668247
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68906674
119* CHD1_26751641_Chip-Seq_LNCaP_Human0.67028912
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.64894952
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.64894952
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.64894952
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.64452032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.89451757
2MP0010094_abnormal_chromosome_stability3.59926537
3MP0003111_abnormal_nucleus_morphology3.33330457
4MP0005365_abnormal_bile_salt3.25218888
5MP0004957_abnormal_blastocyst_morpholog3.07923179
6MP0002139_abnormal_hepatobiliary_system2.92570196
7MP0003077_abnormal_cell_cycle2.92450027
8MP0008058_abnormal_DNA_repair2.86859018
9MP0003123_paternal_imprinting2.77913846
10MP0005360_urolithiasis2.68333584
11MP0003121_genomic_imprinting2.46470270
12MP0005670_abnormal_white_adipose2.33005025
13MP0005085_abnormal_gallbladder_physiolo2.27630561
14MP0008007_abnormal_cellular_replicative2.15756929
15MP0002396_abnormal_hematopoietic_system2.06997656
16MP0009697_abnormal_copulation2.06819751
17MP0000566_synostosis2.06327142
18MP0008057_abnormal_DNA_replication1.98822324
19MP0008932_abnormal_embryonic_tissue1.85238072
20MP0002938_white_spotting1.79035675
21MP0003890_abnormal_embryonic-extraembry1.77284111
22MP0003941_abnormal_skin_development1.75980149
23MP0002638_abnormal_pupillary_reflex1.75405978
24MP0003806_abnormal_nucleotide_metabolis1.72766156
25MP0003718_maternal_effect1.72496266
26MP0008877_abnormal_DNA_methylation1.68224318
27MP0004147_increased_porphyrin_level1.66551733
28MP0008789_abnormal_olfactory_epithelium1.63451493
29MP0009379_abnormal_foot_pigmentation1.61073643
30MP0005075_abnormal_melanosome_morpholog1.59450407
31MP0004133_heterotaxia1.55874607
32MP0003786_premature_aging1.53313371
33MP0000015_abnormal_ear_pigmentation1.52709867
34MP0003937_abnormal_limbs/digits/tail_de1.52661647
35MP0006072_abnormal_retinal_apoptosis1.49105625
36MP0003787_abnormal_imprinting1.47132999
37MP0005394_taste/olfaction_phenotype1.45549383
38MP0005499_abnormal_olfactory_system1.45549383
39MP0004808_abnormal_hematopoietic_stem1.45298339
40MP0005666_abnormal_adipose_tissue1.44677835
41MP0003252_abnormal_bile_duct1.43976689
42MP0002132_abnormal_respiratory_system1.40212193
43MP0000350_abnormal_cell_proliferation1.39778795
44MP0010352_gastrointestinal_tract_polyps1.37505250
45MP0006035_abnormal_mitochondrial_morpho1.35643435
46MP0000609_abnormal_liver_physiology1.34179904
47MP0009840_abnormal_foam_cell1.33134928
48MP0010329_abnormal_lipoprotein_level1.31664438
49MP0003763_abnormal_thymus_physiology1.30771612
50MP0008875_abnormal_xenobiotic_pharmacok1.30454673
51MP0006292_abnormal_olfactory_placode1.30256722
52MP0010307_abnormal_tumor_latency1.25278691
53MP0010030_abnormal_orbit_morphology1.24692088
54MP0001853_heart_inflammation1.24607452
55MP0004185_abnormal_adipocyte_glucose1.24311200
56MP0001929_abnormal_gametogenesis1.24136195
57MP0000372_irregular_coat_pigmentation1.20050784
58MP0002233_abnormal_nose_morphology1.20038075
59MP0005380_embryogenesis_phenotype1.18879256
60MP0001672_abnormal_embryogenesis/_devel1.18879256
61MP0001727_abnormal_embryo_implantation1.18332862
62MP0001730_embryonic_growth_arrest1.15852881
63MP0002971_abnormal_brown_adipose1.14996430
64MP0003186_abnormal_redox_activity1.14474382
65MP0001697_abnormal_embryo_size1.11949353
66MP0000647_abnormal_sebaceous_gland1.11448408
67MP0005253_abnormal_eye_physiology1.11099185
68MP0002160_abnormal_reproductive_system1.10304262
69MP0006036_abnormal_mitochondrial_physio1.09317948
70MP0003984_embryonic_growth_retardation1.07866047
71MP0002697_abnormal_eye_size1.06891537
72MP0000358_abnormal_cell_content/1.06793795
73MP0002088_abnormal_embryonic_growth/wei1.05987576
74MP0002019_abnormal_tumor_incidence1.05975666
75MP0000631_abnormal_neuroendocrine_gland1.04690512
76MP0002086_abnormal_extraembryonic_tissu1.03600203
77MP0000689_abnormal_spleen_morphology1.03278454
78MP0003119_abnormal_digestive_system1.02741829
79MP0003567_abnormal_fetal_cardiomyocyte1.02206530
80MP0001666_abnormal_nutrient_absorption1.02099169
81MP0005391_vision/eye_phenotype1.01884395
82MP0006276_abnormal_autonomic_nervous1.01032635
83MP0001145_abnormal_male_reproductive1.00557713
84MP0000313_abnormal_cell_death0.98682424
85MP0002080_prenatal_lethality0.97520696
86MP0001835_abnormal_antigen_presentation0.96818647
87MP0001286_abnormal_eye_development0.95669674
88MP0000653_abnormal_sex_gland0.95017992
89MP0000598_abnormal_liver_morphology0.92599763
90MP0004197_abnormal_fetal_growth/weight/0.92111740
91MP0003861_abnormal_nervous_system0.91711353
92MP0005174_abnormal_tail_pigmentation0.91333808
93MP0004130_abnormal_muscle_cell0.90693087
94MP0001119_abnormal_female_reproductive0.89562190
95MP0002085_abnormal_embryonic_tissue0.89551392
96MP0009765_abnormal_xenobiotic_induced0.88657399
97MP0009703_decreased_birth_body0.88654981
98MP0001293_anophthalmia0.88567111
99MP0001873_stomach_inflammation0.88507399
100MP0003221_abnormal_cardiomyocyte_apopto0.87789932
101MP0003698_abnormal_male_reproductive0.87683569
102MP0001800_abnormal_humoral_immune0.87538650
103MP0001764_abnormal_homeostasis0.84794262
104MP0002084_abnormal_developmental_patter0.83580321
105MP0002092_abnormal_eye_morphology0.82187546
106MP0001919_abnormal_reproductive_system0.81965865
107MP0005408_hypopigmentation0.81432818
108MP0002722_abnormal_immune_system0.80768271
109MP0002398_abnormal_bone_marrow0.80144465
110MP0002102_abnormal_ear_morphology0.80015806
111MP0002210_abnormal_sex_determination0.79879860
112MP0000428_abnormal_craniofacial_morphol0.79591424
113MP0001529_abnormal_vocalization0.79227094
114MP0002009_preneoplasia0.79012793
115MP0005084_abnormal_gallbladder_morpholo0.78743464
116MP0009053_abnormal_anal_canal0.78424534
117MP0003950_abnormal_plasma_membrane0.76887972
118MP0001188_hyperpigmentation0.75591378
119MP0000703_abnormal_thymus_morphology0.74503448
120MP0002970_abnormal_white_adipose0.74159010
121MP0005332_abnormal_amino_acid0.74122210
122MP0002111_abnormal_tail_morphology0.74090297
123MP0005319_abnormal_enzyme/_coenzyme0.73709139
124MP0005076_abnormal_cell_differentiation0.73087498
125MP0002095_abnormal_skin_pigmentation0.71360431
126MP0003315_abnormal_perineum_morphology0.71270203
127MP0005395_other_phenotype0.71258015
128MP0000490_abnormal_crypts_of0.70804638
129MP0009672_abnormal_birth_weight0.70749962
130MP0003943_abnormal_hepatobiliary_system0.70460051
131MP0008995_early_reproductive_senescence0.69776592
132MP0000049_abnormal_middle_ear0.69408761
133MP0003385_abnormal_body_wall0.68454547
134MP0002163_abnormal_gland_morphology0.67982912
135MP0003755_abnormal_palate_morphology0.66238571
136MP0005384_cellular_phenotype0.66041780
137MP0005389_reproductive_system_phenotype0.65776028
138MP0002452_abnormal_antigen_presenting0.65609598
139MP0002161_abnormal_fertility/fecundity0.65141806
140MP0002090_abnormal_vision0.63020760
141MP0002751_abnormal_autonomic_nervous0.62568227
142MP0003935_abnormal_craniofacial_develop0.62096329
143MP0003699_abnormal_female_reproductive0.60136474
144MP0005187_abnormal_penis_morphology0.58816140
145MP0002184_abnormal_innervation0.58800365
146MP0001661_extended_life_span0.58625108
147MP0000778_abnormal_nervous_system0.58367865
148MP0001984_abnormal_olfaction0.57384462

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.46240599
2Breast hypoplasia (HP:0003187)3.63697126
3Abnormality of the labia minora (HP:0012880)3.36362885
4Aplastic anemia (HP:0001915)3.11673496
5Abnormality of chromosome stability (HP:0003220)3.06689339
6Patellar aplasia (HP:0006443)3.05537928
7Microvesicular hepatic steatosis (HP:0001414)2.93001601
8Meckel diverticulum (HP:0002245)2.84489043
9Aplasia/Hypoplasia of the uvula (HP:0010293)2.82283676
10Abnormality of the preputium (HP:0100587)2.81446442
11Chromsome breakage (HP:0040012)2.75928978
12Aplasia/Hypoplasia of the patella (HP:0006498)2.74136546
13Type 2 muscle fiber atrophy (HP:0003554)2.72863758
14Abnormality of the ileum (HP:0001549)2.72394416
15Volvulus (HP:0002580)2.66733774
16Oral leukoplakia (HP:0002745)2.61513913
17Muscle fiber atrophy (HP:0100295)2.60081411
18Hypobetalipoproteinemia (HP:0003563)2.59856374
19Colon cancer (HP:0003003)2.53610601
20Dynein arm defect of respiratory motile cilia (HP:0012255)2.52960988
21Absent/shortened dynein arms (HP:0200106)2.52960988
22Renal cortical cysts (HP:0000803)2.51529728
23Hyperammonemia (HP:0001987)2.50810490
24Abnormality of serum amino acid levels (HP:0003112)2.47112509
25Nephroblastoma (Wilms tumor) (HP:0002667)2.43335659
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39777369
27Hyperglycinuria (HP:0003108)2.39250122
28Abnormality of cells of the erythroid lineage (HP:0012130)2.38080695
29Spastic diplegia (HP:0001264)2.37612287
30Duodenal stenosis (HP:0100867)2.34578109
31Small intestinal stenosis (HP:0012848)2.34578109
323-Methylglutaconic aciduria (HP:0003535)2.26981276
33Lip pit (HP:0100267)2.26784354
34Poikiloderma (HP:0001029)2.26243647
35Acute encephalopathy (HP:0006846)2.22944886
36Embryonal renal neoplasm (HP:0011794)2.22105927
37Multiple enchondromatosis (HP:0005701)2.20800765
38Horseshoe kidney (HP:0000085)2.19225320
39Medulloblastoma (HP:0002885)2.17887781
40Reticulocytopenia (HP:0001896)2.17043776
41Acute necrotizing encephalopathy (HP:0006965)2.14031806
42Agnosia (HP:0010524)2.12884974
43Sloping forehead (HP:0000340)2.12687580
44Bifid tongue (HP:0010297)2.12590335
45Recurrent sinusitis (HP:0011108)2.12162344
46Ectopic kidney (HP:0000086)2.10391395
47Abnormality of the duodenum (HP:0002246)2.09632502
48Abnormal ciliary motility (HP:0012262)2.09604494
49Increased hepatocellular lipid droplets (HP:0006565)2.08987018
50Abnormal number of erythroid precursors (HP:0012131)2.08533577
51Triphalangeal thumb (HP:0001199)2.08128384
52Epidermoid cyst (HP:0200040)2.07207977
53Chronic hepatic failure (HP:0100626)2.06696408
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06500137
55Abnormality of methionine metabolism (HP:0010901)2.05770981
56Increased CSF lactate (HP:0002490)2.05285235
57Rough bone trabeculation (HP:0100670)2.04354047
58Facial cleft (HP:0002006)2.03769604
59Testicular atrophy (HP:0000029)2.03568673
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01513434
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01513434
62Cellular immunodeficiency (HP:0005374)2.01301889
63Intestinal atresia (HP:0011100)2.01209627
64Hypolipoproteinemia (HP:0010981)2.00681081
65Overlapping toe (HP:0001845)1.99579721
66Myelodysplasia (HP:0002863)1.99492827
67Hyperglycinemia (HP:0002154)1.97688944
68Panhypogammaglobulinemia (HP:0003139)1.97009449
69Generalized aminoaciduria (HP:0002909)1.96251155
70Abnormality of serine family amino acid metabolism (HP:0010894)1.95811774
71Abnormality of glycine metabolism (HP:0010895)1.95811774
72Pallor (HP:0000980)1.94400903
73Duplicated collecting system (HP:0000081)1.94191349
74Lipid accumulation in hepatocytes (HP:0006561)1.93992521
75True hermaphroditism (HP:0010459)1.93308643
76Abnormal mitochondria in muscle tissue (HP:0008316)1.91958461
77Absent radius (HP:0003974)1.91415032
78Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91412053
79Submucous cleft hard palate (HP:0000176)1.91145853
80Complement deficiency (HP:0004431)1.88984563
81Abnormality of midbrain morphology (HP:0002418)1.88908243
82Molar tooth sign on MRI (HP:0002419)1.88908243
83Abdominal situs inversus (HP:0003363)1.87503273
84Abnormality of abdominal situs (HP:0011620)1.87503273
85Intrahepatic cholestasis (HP:0001406)1.87468767
86Abnormality of glycolysis (HP:0004366)1.86170459
87Increased serum pyruvate (HP:0003542)1.86170459
88Mitochondrial inheritance (HP:0001427)1.85769051
89Abnormality of cochlea (HP:0000375)1.85603074
90Supernumerary spleens (HP:0009799)1.85306486
91Megaloblastic anemia (HP:0001889)1.84525618
92Abnormality of the anterior horn cell (HP:0006802)1.84387157
93Degeneration of anterior horn cells (HP:0002398)1.84387157
94Increased nuchal translucency (HP:0010880)1.82970904
95Glioma (HP:0009733)1.81955267
96Neoplasm of the colon (HP:0100273)1.81308744
97Abnormal respiratory motile cilium physiology (HP:0012261)1.81200316
98Macrocytic anemia (HP:0001972)1.80888082
99Preaxial hand polydactyly (HP:0001177)1.80546538
100Thrombocytosis (HP:0001894)1.80461362
101Abnormal spermatogenesis (HP:0008669)1.80387289
102Short middle phalanx of the 5th finger (HP:0004220)1.80267615
103Abnormality of the renal collecting system (HP:0004742)1.79409886
104IgM deficiency (HP:0002850)1.79153193
105Oculomotor apraxia (HP:0000657)1.78704993
106Abnormality of pyrimidine metabolism (HP:0004353)1.78612495
107Papillary thyroid carcinoma (HP:0002895)1.78507460
108Abnormality of DNA repair (HP:0003254)1.78390079
109Aplasia involving forearm bones (HP:0009822)1.77801621
110Absent forearm bone (HP:0003953)1.77801621
111Seborrheic dermatitis (HP:0001051)1.76357038
112Ependymoma (HP:0002888)1.75821572
113Hepatocellular necrosis (HP:0001404)1.75496668
114Lethargy (HP:0001254)1.75408495
115Aplasia/Hypoplasia of the thymus (HP:0010515)1.75075614
116Hypoplasia of the pons (HP:0012110)1.75073169
117Absent thumb (HP:0009777)1.74894581
118Opisthotonus (HP:0002179)1.74269768
119Premature ovarian failure (HP:0008209)1.74132149
120Abnormal lung lobation (HP:0002101)1.74061973
121Cerebral edema (HP:0002181)1.73739356
122Abnormality of the carotid arteries (HP:0005344)1.73734282
123Pancreatic cysts (HP:0001737)1.73590194
124Female pseudohermaphroditism (HP:0010458)1.73277979
125Asplenia (HP:0001746)1.72849576
126Pancreatic fibrosis (HP:0100732)1.72400719
127Abnormal respiratory motile cilium morphology (HP:0005938)1.72346709
128Abnormal respiratory epithelium morphology (HP:0012253)1.72346709
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.72218835
130Abnormality of the pons (HP:0007361)1.71763113
131Hypoplasia of the thymus (HP:0000778)1.71378474
132CNS hypomyelination (HP:0003429)1.70704620
133Long foot (HP:0001833)1.70120259
134Abnormality of placental membranes (HP:0011409)1.69764867
135Amniotic constriction ring (HP:0009775)1.69764867
136Abnormal number of incisors (HP:0011064)1.69735431
137Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.69214008
138Cortical dysplasia (HP:0002539)1.69146904
139Popliteal pterygium (HP:0009756)1.69118625
140Shawl scrotum (HP:0000049)1.68988841
141Carpal bone hypoplasia (HP:0001498)1.68959221
142Gonadotropin excess (HP:0000837)1.68853706
143Impulsivity (HP:0100710)1.68815216
144Limb hypertonia (HP:0002509)1.68668151
145Shoulder girdle muscle weakness (HP:0003547)1.68172318
146Abnormality of the metopic suture (HP:0005556)1.67991883
147Homocystinuria (HP:0002156)1.67912450
148Abnormality of homocysteine metabolism (HP:0010919)1.67912450
149Rhabdomyosarcoma (HP:0002859)1.67869725
150Progressive macrocephaly (HP:0004481)1.67809444
151Hypoalphalipoproteinemia (HP:0003233)1.67631363
152Nephronophthisis (HP:0000090)1.66988712
153Abnormality of the clitoris (HP:0000056)1.66934950
154Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66584919
155Respiratory difficulties (HP:0002880)1.65574823
156Agammaglobulinemia (HP:0004432)1.65557385
157Tubulointerstitial nephritis (HP:0001970)1.64892277
158Rimmed vacuoles (HP:0003805)1.64773751
159Optic nerve coloboma (HP:0000588)1.64470929
160Acute myeloid leukemia (HP:0004808)1.64380357
161Neonatal hypoglycemia (HP:0001998)1.64312034
162Prominent metopic ridge (HP:0005487)1.64138244
163Clitoromegaly (HP:0000057)1.63569678
164Progressive external ophthalmoplegia (HP:0000590)1.62575505
165Increased serum lactate (HP:0002151)1.62324660
166Median cleft lip (HP:0000161)1.61798308
167Bile duct proliferation (HP:0001408)1.61776078
168Abnormal biliary tract physiology (HP:0012439)1.61776078
169Choanal atresia (HP:0000453)1.61337099
170Abnormality of the astrocytes (HP:0100707)1.60593651
171Astrocytoma (HP:0009592)1.60593651
172Hepatic necrosis (HP:0002605)1.59339464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.44696934
2PLK42.96159341
3BRSK22.89983158
4SRPK12.83494433
5BCKDK2.63895824
6CDC72.41169115
7TSSK62.39266769
8PBK2.38485415
9BUB12.31829456
10MKNK12.22486508
11MKNK22.16103268
12STK162.13199892
13NME21.98724303
14VRK11.91108919
15VRK21.85237526
16TAOK21.79289777
17EIF2AK31.78322459
18TTK1.75751324
19ATR1.71182774
20PASK1.70154997
21PLK31.65657721
22EIF2AK11.63538618
23RPS6KB21.56279023
24NME11.55369132
25TRIM281.49837205
26MAP3K41.48573191
27MST41.45102523
28WNK31.43660922
29PLK11.39982394
30BRD41.37697323
31BRSK11.34877124
32LATS11.34866549
33TGFBR21.33224878
34TNIK1.32572200
35INSRR1.29460771
36CDK191.28730105
37MAP3K51.27758574
38TAF11.26892645
39TGFBR11.25888486
40ZAK1.25176350
41CDK41.25118093
42CSF1R1.23002116
43ERBB31.18930979
44AURKB1.15800176
45MAP3K61.13936918
46BCR1.08923860
47TYK21.08801440
48CDK71.08419448
49EIF2AK21.06175172
50SCYL21.05058278
51MAP3K101.03187755
52MAP4K21.02310369
53MAP4K11.02152027
54AURKA1.00643471
55CLK11.00073080
56DYRK30.98967147
57TLK10.98418055
58CDK90.95265539
59CDK60.94526722
60NUAK10.93251335
61YES10.92556122
62STK240.92315664
63STK30.92309211
64FLT30.92046406
65CAMK1D0.90741696
66MOS0.90487524
67ATM0.89491166
68EEF2K0.88800111
69TEC0.87961799
70CCNB10.87331406
71CDK120.87210340
72PNCK0.86217403
73RPS6KA40.84314991
74CHEK10.83214722
75KIT0.82735544
76NEK20.80821147
77MAP2K70.77665007
78STK100.76610843
79CAMK1G0.75865053
80PKN20.74443679
81GRK10.72605191
82PDK40.72381977
83PDK30.72381977
84MAP3K90.71568157
85CDK20.71527106
86MAPK130.70707408
87CSNK1G10.68636671
88MAPK150.68551696
89RAF10.66793637
90KSR10.66526409
91AKT20.66132559
92BTK0.64247701
93PIM10.64168717
94CSNK1E0.63552968
95NEK10.63242105
96ILK0.62789434
97CHEK20.62254122
98RPS6KB10.62106061
99STK40.61507953
100FRK0.60758101
101CSNK1G30.59005693
102PLK20.58120353
103RPS6KL10.57650086
104RPS6KC10.57650086
105LATS20.56614746
106PDK20.56481477
107DYRK20.56436701
108PRKDC0.56017308
109CSNK2A20.55855672
110EPHA20.55735153
111PAK40.54363007
112CASK0.53624749
113BMPR1B0.52955158
114CDK80.51541177
115ERBB40.51321663
116CDK10.50851582
117CSNK2A10.50259200
118FES0.49730715
119MELK0.49458253
120SIK30.48436105
121STK38L0.48375174
122MAP2K60.48258747
123ALK0.47966266
124TNK20.47098720
125MAP3K80.46678162
126TAOK30.46178372
127CHUK0.45582316
128NLK0.45068885
129DAPK10.44301074
130CDK30.44235366
131CSNK1G20.44233239
132FGFR10.44077504
133RPS6KA60.43930924
134SIK10.42269157
135LYN0.42191645
136DMPK0.39341903
137NEK90.37344033
138CSNK1A1L0.35860655
139BRAF0.35200973
140BMPR20.26735730
141RPS6KA50.26389406
142GSK3B0.24355522
143MAPKAPK50.23848936
144MAPK140.23100717
145PRKCG0.21302628

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.34591145
2DNA replication_Homo sapiens_hsa030303.28828260
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.24169372
4Ribosome_Homo sapiens_hsa030103.09086594
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00258096
6Mismatch repair_Homo sapiens_hsa034302.99615440
7Spliceosome_Homo sapiens_hsa030402.58888915
8RNA transport_Homo sapiens_hsa030132.43748193
9Proteasome_Homo sapiens_hsa030502.38393716
10Homologous recombination_Homo sapiens_hsa034402.28934872
11RNA polymerase_Homo sapiens_hsa030202.27672068
12Base excision repair_Homo sapiens_hsa034102.23362656
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.19499250
14Pyrimidine metabolism_Homo sapiens_hsa002402.10105719
15Nucleotide excision repair_Homo sapiens_hsa034202.05036528
16Primary bile acid biosynthesis_Homo sapiens_hsa001202.01406850
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97254020
18Non-homologous end-joining_Homo sapiens_hsa034501.95899704
19Oxidative phosphorylation_Homo sapiens_hsa001901.93955490
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93746126
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.92139687
22Basal transcription factors_Homo sapiens_hsa030221.82724397
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80883537
24RNA degradation_Homo sapiens_hsa030181.76138768
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75160540
26Cell cycle_Homo sapiens_hsa041101.68552652
27Propanoate metabolism_Homo sapiens_hsa006401.65628831
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60148942
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.53541909
30Selenocompound metabolism_Homo sapiens_hsa004501.52514293
31Fanconi anemia pathway_Homo sapiens_hsa034601.52164298
32Vitamin B6 metabolism_Homo sapiens_hsa007501.47835069
33Steroid biosynthesis_Homo sapiens_hsa001001.40277018
34Biosynthesis of amino acids_Homo sapiens_hsa012301.37990071
35Fatty acid degradation_Homo sapiens_hsa000711.32062955
36Protein export_Homo sapiens_hsa030601.30357485
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.24474033
38Peroxisome_Homo sapiens_hsa041461.16362564
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14061366
40Tryptophan metabolism_Homo sapiens_hsa003801.13759643
41mRNA surveillance pathway_Homo sapiens_hsa030151.11912226
42Carbon metabolism_Homo sapiens_hsa012001.10645117
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.10439867
44Alzheimers disease_Homo sapiens_hsa050101.07609964
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07298597
46Arginine biosynthesis_Homo sapiens_hsa002201.05455128
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04168669
48Oocyte meiosis_Homo sapiens_hsa041141.01256025
49PPAR signaling pathway_Homo sapiens_hsa033201.00675550
50p53 signaling pathway_Homo sapiens_hsa041150.95519836
51Primary immunodeficiency_Homo sapiens_hsa053400.95189980
52beta-Alanine metabolism_Homo sapiens_hsa004100.94341850
53Pyruvate metabolism_Homo sapiens_hsa006200.93764666
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93634967
55Purine metabolism_Homo sapiens_hsa002300.93572275
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89905527
57Fatty acid metabolism_Homo sapiens_hsa012120.87616737
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84161961
59Folate biosynthesis_Homo sapiens_hsa007900.83248558
60Antigen processing and presentation_Homo sapiens_hsa046120.79821270
61Complement and coagulation cascades_Homo sapiens_hsa046100.75396410
62Butanoate metabolism_Homo sapiens_hsa006500.75369121
63Systemic lupus erythematosus_Homo sapiens_hsa053220.73498689
64Lysine degradation_Homo sapiens_hsa003100.71006951
65Staphylococcus aureus infection_Homo sapiens_hsa051500.69347094
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69186242
67Epstein-Barr virus infection_Homo sapiens_hsa051690.68631188
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67889887
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66371739
70Herpes simplex infection_Homo sapiens_hsa051680.60416152
71Cardiac muscle contraction_Homo sapiens_hsa042600.55331126
72Fatty acid elongation_Homo sapiens_hsa000620.54305792
73Thyroid cancer_Homo sapiens_hsa052160.54228006
74Alcoholism_Homo sapiens_hsa050340.51367857
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51002075
76Phenylalanine metabolism_Homo sapiens_hsa003600.50885676
77Other glycan degradation_Homo sapiens_hsa005110.50420292
78Regulation of autophagy_Homo sapiens_hsa041400.50420169
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49207331
80* Metabolic pathways_Homo sapiens_hsa011000.49146498
81Hedgehog signaling pathway_Homo sapiens_hsa043400.48555019
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47377803
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46238393
84Viral carcinogenesis_Homo sapiens_hsa052030.44971679
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.44873963
86Tyrosine metabolism_Homo sapiens_hsa003500.43751484
87Basal cell carcinoma_Homo sapiens_hsa052170.43483432
88Huntingtons disease_Homo sapiens_hsa050160.39560647
89HTLV-I infection_Homo sapiens_hsa051660.39519715
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36834984
91Circadian rhythm_Homo sapiens_hsa047100.36290730
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35035536
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34177107
94TGF-beta signaling pathway_Homo sapiens_hsa043500.33522616
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33158960
96B cell receptor signaling pathway_Homo sapiens_hsa046620.31290441
97Olfactory transduction_Homo sapiens_hsa047400.29927576
98Wnt signaling pathway_Homo sapiens_hsa043100.28892271
99Sulfur relay system_Homo sapiens_hsa041220.25979944
100Vitamin digestion and absorption_Homo sapiens_hsa049770.25868104
101Retinol metabolism_Homo sapiens_hsa008300.25865845
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24725193
103Hippo signaling pathway_Homo sapiens_hsa043900.23997705
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23852968
105Chemical carcinogenesis_Homo sapiens_hsa052040.23272154
106Arginine and proline metabolism_Homo sapiens_hsa003300.23155457
107N-Glycan biosynthesis_Homo sapiens_hsa005100.23135882
108Parkinsons disease_Homo sapiens_hsa050120.22524146
109Arachidonic acid metabolism_Homo sapiens_hsa005900.22088004
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.20700924
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20328508
112Nitrogen metabolism_Homo sapiens_hsa009100.18804447
113MicroRNAs in cancer_Homo sapiens_hsa052060.18590398
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18035590
115Apoptosis_Homo sapiens_hsa042100.17865399
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.17862433
117Glutathione metabolism_Homo sapiens_hsa004800.17840357
118Ether lipid metabolism_Homo sapiens_hsa005650.17815999
119Glucagon signaling pathway_Homo sapiens_hsa049220.17296746
120Adherens junction_Homo sapiens_hsa045200.17162339
121Pentose phosphate pathway_Homo sapiens_hsa000300.15607828
122Colorectal cancer_Homo sapiens_hsa052100.13940356
123Sulfur metabolism_Homo sapiens_hsa009200.13337068
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12664403
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11759652
126Nicotine addiction_Homo sapiens_hsa050330.10969225
127Phototransduction_Homo sapiens_hsa047440.06337948
128Fructose and mannose metabolism_Homo sapiens_hsa000510.05910122

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