TRMO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.15178772
2telomere maintenance via semi-conservative replication (GO:0032201)4.64334178
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58510824
4DNA deamination (GO:0045006)4.50076482
5maturation of SSU-rRNA (GO:0030490)4.47269359
6ribosomal small subunit assembly (GO:0000028)4.44671540
7positive regulation of gamma-delta T cell activation (GO:0046645)4.41101689
8DNA strand elongation involved in DNA replication (GO:0006271)4.40791687
9DNA strand elongation (GO:0022616)4.37645346
10CENP-A containing nucleosome assembly (GO:0034080)4.36841175
11regulation of B cell receptor signaling pathway (GO:0050855)4.32956138
12chromatin remodeling at centromere (GO:0031055)4.24676030
13telomere maintenance via recombination (GO:0000722)4.22474809
14rRNA modification (GO:0000154)4.20628973
15DNA replication checkpoint (GO:0000076)4.02793618
16protein localization to kinetochore (GO:0034501)3.99841215
17DNA replication initiation (GO:0006270)3.99073674
18ribosomal small subunit biogenesis (GO:0042274)3.97594940
19kinetochore assembly (GO:0051382)3.96940387
20kinetochore organization (GO:0051383)3.94876957
21negative regulation of cell killing (GO:0031342)3.94023616
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.94023616
23mitotic metaphase plate congression (GO:0007080)3.92829112
24mitotic recombination (GO:0006312)3.91999747
25purine nucleobase biosynthetic process (GO:0009113)3.91475040
26negative regulation of glycoprotein biosynthetic process (GO:0010561)3.90530381
27ribosome biogenesis (GO:0042254)3.90381699
28nucleobase biosynthetic process (GO:0046112)3.88641801
29ribonucleoprotein complex biogenesis (GO:0022613)3.84916994
30ribosomal large subunit biogenesis (GO:0042273)3.79900957
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78003171
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.78003171
33modulation by symbiont of host immune response (GO:0052553)3.78003171
34positive regulation by symbiont of host defense response (GO:0052509)3.78003171
35modulation by symbiont of host defense response (GO:0052031)3.78003171
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78003171
37negative regulation of interleukin-12 production (GO:0032695)3.74774195
38telomere maintenance via telomere lengthening (GO:0010833)3.74429984
39DNA replication-independent nucleosome assembly (GO:0006336)3.73026336
40DNA replication-independent nucleosome organization (GO:0034724)3.73026336
41negative T cell selection (GO:0043383)3.70959778
42rRNA methylation (GO:0031167)3.67328062
43negative thymic T cell selection (GO:0045060)3.65145198
44attachment of spindle microtubules to kinetochore (GO:0008608)3.63337900
45neutrophil activation involved in immune response (GO:0002283)3.60385538
46positive regulation of granulocyte differentiation (GO:0030854)3.55851378
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.54578582
48histone exchange (GO:0043486)3.54378544
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.52121785
50tolerance induction (GO:0002507)3.51047055
51rRNA processing (GO:0006364)3.47731601
527-methylguanosine mRNA capping (GO:0006370)3.47252865
53regulation of gamma-delta T cell activation (GO:0046643)3.46762706
54protein localization to chromosome, centromeric region (GO:0071459)3.46636719
55viral transcription (GO:0019083)3.46200060
56transcription elongation from RNA polymerase III promoter (GO:0006385)3.44656635
57termination of RNA polymerase III transcription (GO:0006386)3.44656635
58transcription-coupled nucleotide-excision repair (GO:0006283)3.44567696
59metaphase plate congression (GO:0051310)3.43674999
60activated T cell proliferation (GO:0050798)3.42717441
61RNA capping (GO:0036260)3.39437513
627-methylguanosine RNA capping (GO:0009452)3.39437513
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38531064
64translational termination (GO:0006415)3.38306998
65regulation of gamma-delta T cell differentiation (GO:0045586)3.36853121
66rRNA metabolic process (GO:0016072)3.36675411
67immunoglobulin mediated immune response (GO:0016064)3.36650006
68positive thymic T cell selection (GO:0045059)3.36054584
69regulation of regulatory T cell differentiation (GO:0045589)3.34643697
70regulation of double-strand break repair via homologous recombination (GO:0010569)3.32926440
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32895578
72proteasome assembly (GO:0043248)3.31935331
73macrophage activation involved in immune response (GO:0002281)3.31757073
74termination of RNA polymerase I transcription (GO:0006363)3.27987795
75positive T cell selection (GO:0043368)3.24912799
76antigen processing and presentation of endogenous antigen (GO:0019883)3.23651013
77formation of translation preinitiation complex (GO:0001731)3.23164734
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.21948613
79meiotic chromosome segregation (GO:0045132)3.20332069
80establishment of chromosome localization (GO:0051303)3.20054620
81spliceosomal snRNP assembly (GO:0000387)3.19115212
82regulation of interferon-beta biosynthetic process (GO:0045357)3.18799918
83G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.18379844
84transcription from RNA polymerase I promoter (GO:0006360)3.17515358
85ribosome assembly (GO:0042255)3.16248404
86protein K6-linked ubiquitination (GO:0085020)3.16231357
87transcription elongation from RNA polymerase I promoter (GO:0006362)3.14013462
88L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12322910
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12250939
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10524689
91T cell migration (GO:0072678)3.10344740
92pseudouridine synthesis (GO:0001522)3.09354902
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08518915
94detection of other organism (GO:0098543)3.08176045
95detection of molecule of bacterial origin (GO:0032490)3.07904998
96negative regulation of thymocyte apoptotic process (GO:0070244)3.07694241
97DNA replication-dependent nucleosome assembly (GO:0006335)3.07585636
98DNA replication-dependent nucleosome organization (GO:0034723)3.07585636
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07287671
100translational elongation (GO:0006414)3.07018072
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04940133
102neutrophil activation (GO:0042119)3.04884663
103cellular component biogenesis (GO:0044085)3.04863465
104mismatch repair (GO:0006298)3.03049115
105maturation of 5.8S rRNA (GO:0000460)3.02889084
106IMP biosynthetic process (GO:0006188)3.02803523
107translational initiation (GO:0006413)3.02031223
108regulation of alpha-beta T cell proliferation (GO:0046640)3.01274568
109telomere maintenance (GO:0000723)3.01085920
110telomere organization (GO:0032200)3.00894550
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00822645
112antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.00420417
113B cell receptor signaling pathway (GO:0050853)3.00085039
114nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99993698
115B cell mediated immunity (GO:0019724)2.99954700
116negative regulation of glycoprotein metabolic process (GO:1903019)2.99378101
117response to interleukin-15 (GO:0070672)2.99374822
118DNA synthesis involved in DNA repair (GO:0000731)2.99211257
119microglial cell activation (GO:0001774)2.99029172
120cellular extravasation (GO:0045123)2.98377106
121Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97159056
122interferon-gamma secretion (GO:0072643)2.96569394
123cotranslational protein targeting to membrane (GO:0006613)2.96351423
124interferon-gamma-mediated signaling pathway (GO:0060333)2.94868519
125positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94342619
126DNA-dependent DNA replication (GO:0006261)2.94130074
127protein targeting to ER (GO:0045047)2.93834433
128myeloid cell activation involved in immune response (GO:0002275)2.91255962
129positive regulation of B cell differentiation (GO:0045579)2.91167907
130negative regulation of T cell mediated immunity (GO:0002710)2.90728065
131granulocyte activation (GO:0036230)2.89136402
132response to peptidoglycan (GO:0032494)2.88360777
133regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86737855
134antigen receptor-mediated signaling pathway (GO:0050851)2.86226644
135leukocyte degranulation (GO:0043299)2.86170644
136cellular response to type I interferon (GO:0071357)2.85991839
137type I interferon signaling pathway (GO:0060337)2.85991839
138deoxyribonucleotide biosynthetic process (GO:0009263)2.84795703
139negative regulation of lymphocyte mediated immunity (GO:0002707)2.84728827
140mitotic nuclear envelope disassembly (GO:0007077)2.84503624
141DNA unwinding involved in DNA replication (GO:0006268)2.84268589
142detection of external biotic stimulus (GO:0098581)2.83761079
143translation (GO:0006412)2.83314924
144transcription initiation from RNA polymerase I promoter (GO:0006361)2.82773624
145regulation of isotype switching to IgG isotypes (GO:0048302)2.82600542
146cell cycle G1/S phase transition (GO:0044843)2.82416239
147G1/S transition of mitotic cell cycle (GO:0000082)2.82416239
148leukocyte aggregation (GO:0070486)2.81659928
149tRNA methylation (GO:0030488)2.81483491
150detection of bacterium (GO:0016045)2.80902591
151RNA methylation (GO:0001510)2.80415322
152response to type I interferon (GO:0034340)2.80343514
153protein localization to endoplasmic reticulum (GO:0070972)2.80141935
154maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79957007
155negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79629714
156negative regulation of ligase activity (GO:0051352)2.79629714
157regulation of B cell apoptotic process (GO:0002902)2.79187767
158nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.78980494
159ncRNA processing (GO:0034470)2.78731157
160establishment of protein localization to endoplasmic reticulum (GO:0072599)2.77613501
161T cell receptor signaling pathway (GO:0050852)2.77392501
162T cell selection (GO:0045058)2.76991185
163IMP metabolic process (GO:0046040)2.76966402
164spliceosomal complex assembly (GO:0000245)2.76317571
165mitotic sister chromatid segregation (GO:0000070)2.76052628
166negative regulation of T cell apoptotic process (GO:0070233)2.75812885
167defense response to protozoan (GO:0042832)2.75101032
168DNA-templated transcription, termination (GO:0006353)2.74908613
169signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74378687
170positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74199984
171macrophage activation (GO:0042116)2.74083833
172regulation of T cell tolerance induction (GO:0002664)2.73855674
173cytokine secretion (GO:0050663)2.71791372
174CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.69572736
175T-helper cell differentiation (GO:0042093)2.69572736
176cellular response to interleukin-15 (GO:0071350)2.68596656
177regulation of tolerance induction (GO:0002643)2.66068151
178alpha-beta T cell activation (GO:0046631)2.65945477
179protein K11-linked deubiquitination (GO:0035871)2.65490654
180regulation of B cell differentiation (GO:0045577)2.65275308
181positive regulation of interleukin-1 beta secretion (GO:0050718)2.64716646
182alpha-beta T cell differentiation involved in immune response (GO:0002293)2.64416552
183alpha-beta T cell activation involved in immune response (GO:0002287)2.64416552
184T cell differentiation involved in immune response (GO:0002292)2.64416552
185regulation of T cell receptor signaling pathway (GO:0050856)2.64377372
186thymic T cell selection (GO:0045061)2.64232416
187natural killer cell activation involved in immune response (GO:0002323)2.64230646
188positive regulation of tolerance induction (GO:0002645)2.63833469
189respiratory burst (GO:0045730)2.63666204
190response to host immune response (GO:0052572)2.59976273
191response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.59976273
192positive regulation of alpha-beta T cell proliferation (GO:0046641)2.59132771
193antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.57996278
194myeloid dendritic cell activation (GO:0001773)2.57375409
195neutrophil mediated immunity (GO:0002446)2.56967867
196regulation of interleukin-1 beta secretion (GO:0050706)2.56296559
197response to muramyl dipeptide (GO:0032495)2.56266657
198T cell activation involved in immune response (GO:0002286)2.56079209
199alpha-beta T cell differentiation (GO:0046632)2.54756690
200cell activation involved in immune response (GO:0002263)2.54424948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.49332061
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.99241368
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.14667671
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.02065165
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97787602
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.97166131
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.95272077
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59322234
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.50619674
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.43765357
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.40421372
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33284586
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21972419
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08385361
15ETS1_20019798_ChIP-Seq_JURKAT_Human3.06583021
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95500378
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.85469313
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81723858
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81238730
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80353369
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79032418
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75360174
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.74316310
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73219643
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70157056
26MYB_26560356_Chip-Seq_TH2_Human2.68828631
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62838345
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62106268
29VDR_23849224_ChIP-Seq_CD4+_Human2.55502582
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44491799
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43742388
32RUNX_20019798_ChIP-Seq_JUKART_Human2.37707117
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36398650
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32075925
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31775962
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24929643
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24498184
38MYB_26560356_Chip-Seq_TH1_Human2.22834548
39MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22689637
40XRN2_22483619_ChIP-Seq_HELA_Human2.19636026
41FOXP3_21729870_ChIP-Seq_TREG_Human2.15599415
42SCL_19346495_ChIP-Seq_HPC-7_Human2.12490697
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07080352
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05893525
45E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04296203
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99764658
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.97016684
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95238782
49DCP1A_22483619_ChIP-Seq_HELA_Human1.93766625
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92625060
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.89341330
52GATA3_26560356_Chip-Seq_TH2_Human1.89034080
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87639471
54ELK1_19687146_ChIP-ChIP_HELA_Human1.87463871
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86003292
56TTF2_22483619_ChIP-Seq_HELA_Human1.81921117
57GATA3_27048872_Chip-Seq_THYMUS_Human1.78814050
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76758884
59GABP_19822575_ChIP-Seq_HepG2_Human1.75799567
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.74737813
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74637916
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73118537
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71488023
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.71466862
65MAF_26560356_Chip-Seq_TH1_Human1.70812180
66AR_21909140_ChIP-Seq_LNCAP_Human1.69664381
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68117634
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65104288
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.64310822
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62428040
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61969276
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61587508
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59375431
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56112531
75CIITA_25753668_ChIP-Seq_RAJI_Human1.52468754
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50654187
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49024093
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48808596
79SPI1_23127762_ChIP-Seq_K562_Human1.47586572
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45971715
81VDR_24787735_ChIP-Seq_THP-1_Human1.42679609
82VDR_24763502_ChIP-Seq_THP-1_Human1.42205667
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.36117174
84UTX_26944678_Chip-Seq_JUKART_Human1.34684151
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33779053
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30987510
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30944509
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30862070
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29866478
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28846274
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27993416
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26466826
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26272634
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25579920
95KDM5A_27292631_Chip-Seq_BREAST_Human1.25482586
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22306753
97GATA1_22025678_ChIP-Seq_K562_Human1.21751984
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18906573
99MAF_26560356_Chip-Seq_TH2_Human1.18895486
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15007151
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14252813
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13243877
103MYC_18940864_ChIP-ChIP_HL60_Human1.12866841
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12406914
105SPI1_23547873_ChIP-Seq_NB4_Human1.11487135
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09260620
107GATA2_21666600_ChIP-Seq_HMVEC_Human1.08571715
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08185212
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06755432
110PU_27001747_Chip-Seq_BMDM_Mouse1.06520626
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04962850
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04265800
113SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03931223
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03198121
115STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02751789
116EGR1_19374776_ChIP-ChIP_THP-1_Human1.02644931
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01450700
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99378242
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98287651
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96895796
121TP63_19390658_ChIP-ChIP_HaCaT_Human0.95618442
122CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95076641
123IRF8_21731497_ChIP-ChIP_J774_Mouse0.94782828
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93877851
125SALL4_22934838_ChIP-ChIP_CD34+_Human0.93072414
126VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92860669
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.92014755
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91495264
129GATA3_26560356_Chip-Seq_TH1_Human0.90461441
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90118496
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90004984
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88187179
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88166281
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87592695
135PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86972707
136IRF1_19129219_ChIP-ChIP_H3396_Human0.86753688
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86250593
138SMRT_27268052_Chip-Seq_Bcells_Human0.85962613
139TFEB_21752829_ChIP-Seq_HELA_Human0.85758820
140TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85522715
141TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83365933
142EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82868963
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81258260
144RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80599578
145FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79885525
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79379912
147MYC_22102868_ChIP-Seq_BL_Human0.78672496
148STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78135029
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78130074
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77652389
151POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77082808
152CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73242011
153CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72884770
154RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.72218279
155MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.68712749
156NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68406093
157MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.65641824
158KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65281544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.71240422
2MP0010094_abnormal_chromosome_stability4.62797458
3MP0003111_abnormal_nucleus_morphology4.27153596
4MP0008058_abnormal_DNA_repair4.11922946
5MP0008057_abnormal_DNA_replication4.08141186
6MP0002138_abnormal_hepatobiliary_system3.96114941
7MP0004957_abnormal_blastocyst_morpholog3.77221306
8MP0003724_increased_susceptibility_to3.70182783
9MP0003077_abnormal_cell_cycle3.67307614
10MP0008877_abnormal_DNA_methylation3.08476144
11MP0008007_abnormal_cellular_replicative2.69763913
12MP0001986_abnormal_taste_sensitivity2.34343000
13MP0003786_premature_aging2.33929655
14MP0002396_abnormal_hematopoietic_system2.32468896
15MP0008932_abnormal_embryonic_tissue2.30194769
16MP0003303_peritoneal_inflammation2.21019595
17MP0006082_CNS_inflammation2.19153462
18MP0002132_abnormal_respiratory_system2.16328558
19MP0006054_spinal_hemorrhage2.13193282
20MP0003718_maternal_effect2.11526148
21MP0006292_abnormal_olfactory_placode2.08891035
22MP0009764_decreased_sensitivity_to2.06836894
23MP0002166_altered_tumor_susceptibility1.81555102
24MP0000490_abnormal_crypts_of1.77966164
25MP0010155_abnormal_intestine_physiology1.75683872
26MP0001835_abnormal_antigen_presentation1.71306298
27MP0003763_abnormal_thymus_physiology1.70942572
28MP0001845_abnormal_inflammatory_respons1.69499131
29MP0002210_abnormal_sex_determination1.64326411
30MP0000350_abnormal_cell_proliferation1.57891529
31MP0001533_abnormal_skeleton_physiology1.56910626
32MP0008260_abnormal_autophagy1.53965198
33MP0008469_abnormal_protein_level1.53180283
34MP0002095_abnormal_skin_pigmentation1.52229006
35MP0003252_abnormal_bile_duct1.52073616
36MP0003136_yellow_coat_color1.51984649
37MP0005075_abnormal_melanosome_morpholog1.50626615
38MP0002398_abnormal_bone_marrow1.50626141
39MP0000569_abnormal_digit_pigmentation1.50424482
40MP0009278_abnormal_bone_marrow1.49925492
41MP0009333_abnormal_splenocyte_physiolog1.49620220
42MP0004947_skin_inflammation1.49485853
43MP0009379_abnormal_foot_pigmentation1.46099352
44MP0005671_abnormal_response_to1.42204435
45MP0001929_abnormal_gametogenesis1.41335781
46MP0003172_abnormal_lysosome_physiology1.39987538
47MP0000313_abnormal_cell_death1.39987365
48MP0000689_abnormal_spleen_morphology1.39294502
49MP0001730_embryonic_growth_arrest1.39213347
50MP0002019_abnormal_tumor_incidence1.37922849
51MP0003186_abnormal_redox_activity1.37654814
52MP0004808_abnormal_hematopoietic_stem1.35926010
53MP0002006_tumorigenesis1.35756635
54MP0005310_abnormal_salivary_gland1.35722968
55MP0004147_increased_porphyrin_level1.35187231
56MP0000015_abnormal_ear_pigmentation1.35017304
57MP0002722_abnormal_immune_system1.34950237
58MP0002009_preneoplasia1.34467495
59MP0003300_gastrointestinal_ulcer1.29839593
60MP0001853_heart_inflammation1.28731004
61MP0001145_abnormal_male_reproductive1.26457958
62MP0003191_abnormal_cellular_cholesterol1.26255074
63MP0003806_abnormal_nucleotide_metabolis1.25919918
64MP0000703_abnormal_thymus_morphology1.24353832
65MP0005397_hematopoietic_system_phenotyp1.24238467
66MP0001545_abnormal_hematopoietic_system1.24238467
67MP0001800_abnormal_humoral_immune1.24221766
68MP0001188_hyperpigmentation1.23937128
69MP0005174_abnormal_tail_pigmentation1.19669635
70MP0000653_abnormal_sex_gland1.16729674
71MP0002429_abnormal_blood_cell1.16435519
72MP0009697_abnormal_copulation1.15863703
73MP0000716_abnormal_immune_system1.15772725
74MP0003656_abnormal_erythrocyte_physiolo1.14654390
75MP0002420_abnormal_adaptive_immunity1.12814364
76MP0003123_paternal_imprinting1.11907791
77MP0001819_abnormal_immune_cell1.11372601
78MP0000465_gastrointestinal_hemorrhage1.11268496
79MP0001119_abnormal_female_reproductive1.11183092
80MP0002723_abnormal_immune_serum1.09951974
81MP0002452_abnormal_antigen_presenting1.09423453
82MP0002998_abnormal_bone_remodeling1.08847629
83MP0003828_pulmonary_edema1.08220732
84MP0005451_abnormal_body_composition1.07679345
85MP0000372_irregular_coat_pigmentation1.04296826
86MP0010307_abnormal_tumor_latency1.02176051
87MP0002160_abnormal_reproductive_system1.02128640
88MP0009785_altered_susceptibility_to1.00227307
89MP0003075_altered_response_to0.99212578
90MP0004883_abnormal_blood_vessel0.98159286
91MP0005025_abnormal_response_to0.97108423
92MP0002080_prenatal_lethality0.96515087
93MP0005000_abnormal_immune_tolerance0.95655114
94MP0002933_joint_inflammation0.94102828
95MP0005058_abnormal_lysosome_morphology0.94093277
96MP0003448_altered_tumor_morphology0.93777489
97MP0005164_abnormal_response_to0.93151497
98MP0001672_abnormal_embryogenesis/_devel0.92892924
99MP0005380_embryogenesis_phenotype0.92892924
100MP0000604_amyloidosis0.92590840
101MP0009765_abnormal_xenobiotic_induced0.92186724
102MP0008995_early_reproductive_senescence0.91319972
103MP0005389_reproductive_system_phenotype0.90751441
104MP0002102_abnormal_ear_morphology0.90252749
105MP0006035_abnormal_mitochondrial_morpho0.89672259
106MP0001697_abnormal_embryo_size0.89380951
107MP0003221_abnormal_cardiomyocyte_apopto0.87398983
108MP0002148_abnormal_hypersensitivity_rea0.87374750
109MP0002163_abnormal_gland_morphology0.86169181
110MP0004381_abnormal_hair_follicle0.84924992
111MP0001851_eye_inflammation0.84708108
112MP0004133_heterotaxia0.83827553
113MP0006036_abnormal_mitochondrial_physio0.83643981
114MP0009763_increased_sensitivity_to0.82860039
115MP0002928_abnormal_bile_duct0.82297319
116MP0000685_abnormal_immune_system0.81754152
117MP0003698_abnormal_male_reproductive0.81434413
118MP0001293_anophthalmia0.80840675
119MP0001764_abnormal_homeostasis0.80645628
120MP0002405_respiratory_system_inflammati0.80328317
121MP0002419_abnormal_innate_immunity0.80018537
122MP0001873_stomach_inflammation0.79516631
123MP0000858_altered_metastatic_potential0.78311127
124MP0002693_abnormal_pancreas_physiology0.77627865
125MP0005319_abnormal_enzyme/_coenzyme0.77374924
126MP0001186_pigmentation_phenotype0.76863542
127MP0008873_increased_physiological_sensi0.76137828
128MP0002085_abnormal_embryonic_tissue0.75909168
129MP0003315_abnormal_perineum_morphology0.75053539
130MP0005167_abnormal_blood-brain_barrier0.74871159
131MP0000358_abnormal_cell_content/0.73993241
132MP0003984_embryonic_growth_retardation0.73766154
133MP0001790_abnormal_immune_system0.72881607
134MP0005387_immune_system_phenotype0.72881607
135MP0003183_abnormal_peptide_metabolism0.72492096
136MP0005464_abnormal_platelet_physiology0.71360431
137MP0008004_abnormal_stomach_pH0.70440112
138MP0002332_abnormal_exercise_endurance0.69826593
139MP0003866_abnormal_defecation0.69595368
140MP0008789_abnormal_olfactory_epithelium0.69423851
141MP0002088_abnormal_embryonic_growth/wei0.68934483
142MP0005266_abnormal_metabolism0.68450840
143MP0000609_abnormal_liver_physiology0.68091532
144MP0003795_abnormal_bone_structure0.67999725
145MP0000343_altered_response_to0.65852545
146MP0002075_abnormal_coat/hair_pigmentati0.65638785
147MP0005376_homeostasis/metabolism_phenot0.65118408
148MP0005166_decreased_susceptibility_to0.64841836
149MP0003436_decreased_susceptibility_to0.64429935
150MP0002277_abnormal_respiratory_mucosa0.63529491
151MP0003567_abnormal_fetal_cardiomyocyte0.63478835

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.59486442
2Birth length less than 3rd percentile (HP:0003561)5.36845187
3Recurrent abscess formation (HP:0002722)5.16053502
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.57168833
5Chromsome breakage (HP:0040012)4.38974216
6Reticulocytopenia (HP:0001896)4.38210512
7Abnormality of cells of the erythroid lineage (HP:0012130)4.24478839
8Abnormal number of erythroid precursors (HP:0012131)4.18171867
9Breast hypoplasia (HP:0003187)4.12245863
10Duplicated collecting system (HP:0000081)4.06235184
11Abnormality of the renal collecting system (HP:0004742)4.05021581
12Eczematoid dermatitis (HP:0000976)4.03898377
13Stomatitis (HP:0010280)4.01245963
14Prostate neoplasm (HP:0100787)3.98858893
15T lymphocytopenia (HP:0005403)3.93527975
16Severe combined immunodeficiency (HP:0004430)3.65948506
17Abnormality of T cell number (HP:0011839)3.61130425
18Abnormality of the prostate (HP:0008775)3.59547043
19Retrobulbar optic neuritis (HP:0100654)3.47137083
20Optic neuritis (HP:0100653)3.47137083
21Abnormality of the preputium (HP:0100587)3.34653721
22Panhypogammaglobulinemia (HP:0003139)3.34578684
23Recurrent skin infections (HP:0001581)3.31335847
24Orchitis (HP:0100796)3.28939290
25Combined immunodeficiency (HP:0005387)3.24943998
26Meckel diverticulum (HP:0002245)3.21371736
27Recurrent fungal infections (HP:0002841)3.19631640
28Autoimmune hemolytic anemia (HP:0001890)3.13641158
29Type I transferrin isoform profile (HP:0003642)3.12792100
30Recurrent gram-negative bacterial infections (HP:0005420)3.11498158
31Abnormality of the ileum (HP:0001549)3.10482704
32Carpal bone hypoplasia (HP:0001498)3.09842476
33Abnormality of chromosome stability (HP:0003220)3.09312691
34Mediastinal lymphadenopathy (HP:0100721)3.07089338
35Aplasia/Hypoplasia of the uvula (HP:0010293)3.00865761
36Pustule (HP:0200039)2.98090033
37Rough bone trabeculation (HP:0100670)2.96719648
38Meningitis (HP:0001287)2.96661936
39Patellar aplasia (HP:0006443)2.96484704
40Aplastic anemia (HP:0001915)2.95972248
41Abnormality of the anterior horn cell (HP:0006802)2.95001675
42Degeneration of anterior horn cells (HP:0002398)2.95001675
43Abnormality of macrophages (HP:0004311)2.92076013
44Bone marrow hypocellularity (HP:0005528)2.88156017
45Abnormality of T cells (HP:0002843)2.87000098
46Pallor (HP:0000980)2.84975930
47Vasculitis (HP:0002633)2.83875267
48Recurrent viral infections (HP:0004429)2.83257089
49Oral leukoplakia (HP:0002745)2.79389986
50Clubbing of toes (HP:0100760)2.78583112
51Disinhibition (HP:0000734)2.78094886
52Macrocytic anemia (HP:0001972)2.76764493
53B lymphocytopenia (HP:0010976)2.74930612
54Aplasia/Hypoplasia of the patella (HP:0006498)2.73645599
55Premature graying of hair (HP:0002216)2.73268629
56Eosinophilia (HP:0001880)2.70555388
57Myelodysplasia (HP:0002863)2.68990419
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.68910693
59Absent thumb (HP:0009777)2.67354165
60Autoimmune thrombocytopenia (HP:0001973)2.66008686
61Abnormality of B cell number (HP:0010975)2.65139751
62Increased IgE level (HP:0003212)2.63383115
6311 pairs of ribs (HP:0000878)2.62251765
64Leukocytosis (HP:0001974)2.60618832
65Loss of speech (HP:0002371)2.60205865
66Cerebral hypomyelination (HP:0006808)2.59101779
67Absent radius (HP:0003974)2.58966275
68Keratoconjunctivitis sicca (HP:0001097)2.57491255
69Abnormality of secondary sexual hair (HP:0009888)2.57438638
70Abnormality of the axillary hair (HP:0100134)2.57438638
71Acute lymphatic leukemia (HP:0006721)2.55495071
72Bile duct proliferation (HP:0001408)2.54907075
73Abnormal biliary tract physiology (HP:0012439)2.54907075
74Obstructive lung disease (HP:0006536)2.53252785
75Chronic obstructive pulmonary disease (HP:0006510)2.53252785
76Thyroiditis (HP:0100646)2.53087650
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52358543
78Encephalitis (HP:0002383)2.50984511
79Duodenal stenosis (HP:0100867)2.50650075
80Small intestinal stenosis (HP:0012848)2.50650075
81Abnormality of eosinophils (HP:0001879)2.46205250
82Chest pain (HP:0100749)2.46048138
83Impulsivity (HP:0100710)2.45758105
84Pulmonary infiltrates (HP:0002113)2.44266880
85Vacuolated lymphocytes (HP:0001922)2.42182232
86Abnormal spermatogenesis (HP:0008669)2.40310953
87Dry hair (HP:0011359)2.40193595
88Acute hepatic failure (HP:0006554)2.39053098
89Reduced antithrombin III activity (HP:0001976)2.38689191
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.38651117
913-Methylglutaconic aciduria (HP:0003535)2.37771773
92Absent forearm bone (HP:0003953)2.37057226
93Aplasia involving forearm bones (HP:0009822)2.37057226
94Abnormality of the heme biosynthetic pathway (HP:0010472)2.36972918
95Cellular immunodeficiency (HP:0005374)2.34209512
96Lower limb hyperreflexia (HP:0002395)2.31107812
97Alveolar cell carcinoma (HP:0006519)2.30919764
98Colon cancer (HP:0003003)2.29538379
99Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29316254
100Horseshoe kidney (HP:0000085)2.29266099
101Abnormality of the labia minora (HP:0012880)2.29062230
102Pancreatic fibrosis (HP:0100732)2.25394540
103Pancreatic cysts (HP:0001737)2.25335605
104Keratoconjunctivitis (HP:0001096)2.24318342
105Abnormality of male internal genitalia (HP:0000022)2.24153005
106Sloping forehead (HP:0000340)2.23159312
107Neoplasm of the tracheobronchial system (HP:0100552)2.22967611
108Supernumerary spleens (HP:0009799)2.22744253
109Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22146554
110Recurrent cutaneous fungal infections (HP:0011370)2.19940864
111Chronic mucocutaneous candidiasis (HP:0002728)2.19940864
112Ureteral duplication (HP:0000073)2.19201817
113Abnormality of T cell physiology (HP:0011840)2.18665371
114Abnormal protein glycosylation (HP:0012346)2.17236830
115Abnormal glycosylation (HP:0012345)2.17236830
116Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17236830
117Abnormal protein N-linked glycosylation (HP:0012347)2.17236830
118Type 2 muscle fiber atrophy (HP:0003554)2.15156226
119Abnormal trabecular bone morphology (HP:0100671)2.15075709
120Hemoptysis (HP:0002105)2.15041612
121Microvesicular hepatic steatosis (HP:0001414)2.14475129
122Gingival bleeding (HP:0000225)2.11268974
123IgM deficiency (HP:0002850)2.11124985
124Gastrointestinal infarctions (HP:0005244)2.10837017
125Muscle fiber atrophy (HP:0100295)2.10740786
126Abnormality of glycolipid metabolism (HP:0010969)2.10739182
127Abnormality of liposaccharide metabolism (HP:0010968)2.10739182
128Abnormality of glycosphingolipid metabolism (HP:0004343)2.10739182
129Pancytopenia (HP:0001876)2.10467739
130Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.10358804
131Increased serum lactate (HP:0002151)2.09325166
132Stomach cancer (HP:0012126)2.09107852
133Premature ovarian failure (HP:0008209)2.09072504
134Thrombocytosis (HP:0001894)2.08617225
135Triphalangeal thumb (HP:0001199)2.08366880
136Gangrene (HP:0100758)2.08189837
137Anorexia (HP:0002039)2.08033320
138Arterial thrombosis (HP:0004420)2.07313622
139Agammaglobulinemia (HP:0004432)2.07242958
140Cleft eyelid (HP:0000625)2.06595782
141Abnormality of DNA repair (HP:0003254)2.04538614
142Lymphoma (HP:0002665)2.03150778
143Ragged-red muscle fibers (HP:0003200)2.02536616
144Petechiae (HP:0000967)2.02117096
145Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01939477
146Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01939477
147Ketoacidosis (HP:0001993)2.01541682
148Chronic otitis media (HP:0000389)2.00902335
149Elevated erythrocyte sedimentation rate (HP:0003565)1.99825729
150Abnormality of the duodenum (HP:0002246)1.99682413
151Amyotrophic lateral sclerosis (HP:0007354)1.99366569
152Fair hair (HP:0002286)1.99179966
153Recurrent bronchitis (HP:0002837)1.99044353
154Short thumb (HP:0009778)1.98802958
155Osteomyelitis (HP:0002754)1.98191268
156True hermaphroditism (HP:0010459)1.95634267
157Scanning speech (HP:0002168)1.95117699
158Agnosia (HP:0010524)1.94896470
159Long foot (HP:0001833)1.93058814
160Lymphopenia (HP:0001888)1.91032210
161Abnormal rod and cone electroretinograms (HP:0008323)1.90722400
162Urticaria (HP:0001025)1.90401536
163Ectopic kidney (HP:0000086)1.90387249
164Spontaneous hematomas (HP:0007420)1.89766926
165Microretrognathia (HP:0000308)1.89217454
166Selective tooth agenesis (HP:0001592)1.88644143
167Respiratory difficulties (HP:0002880)1.88598936
168Tracheoesophageal fistula (HP:0002575)1.87883134
169Increased CSF protein (HP:0002922)1.87511941
170Keratitis (HP:0000491)1.87371479
171Myositis (HP:0100614)1.86961927
172Epistaxis (HP:0000421)1.86570163
173Secondary amenorrhea (HP:0000869)1.85937146
174Abnormal lung lobation (HP:0002101)1.85481088
175Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84951323
176Episodic fever (HP:0001954)1.84694077
177Verrucae (HP:0200043)1.84311995
178Papilloma (HP:0012740)1.84311995
179Exertional dyspnea (HP:0002875)1.81825539
180IgG deficiency (HP:0004315)1.81238066
181Hypoplasia of the radius (HP:0002984)1.78499031
182Irregular epiphyses (HP:0010582)1.77354371
183Asplenia (HP:0001746)1.76969130
184Leukopenia (HP:0001882)1.75379161
185Abnormality of the carotid arteries (HP:0005344)1.75094976
186Sparse eyelashes (HP:0000653)1.74326095
187Pulmonary fibrosis (HP:0002206)1.74207013
188Neoplasm of the pancreas (HP:0002894)1.71708091
189Granulocytopenia (HP:0001913)1.71219770
190Abnormality of reticulocytes (HP:0004312)1.69148067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.33690172
2BUB14.13826668
3RIPK44.06959902
4WEE13.69001676
5STK163.59418722
6SRPK13.05465191
7EIF2AK13.01004586
8PLK42.71630872
9CDC72.70722982
10NME22.62835335
11VRK12.61413378
12BRSK22.53003342
13EIF2AK32.35931370
14BMPR22.30610773
15ZAK2.12947789
16TSSK62.08910278
17ITK1.97252213
18DYRK31.92412344
19PLK11.88436751
20CCNB11.77977228
21TTK1.76907417
22ACVR1B1.70932798
23NEK21.68856667
24CSK1.65610025
25IRAK41.64859812
26PLK31.63323310
27MKNK21.63209385
28IRAK31.62243319
29MKNK11.61777780
30BRSK11.60304527
31TLK11.57665665
32ATR1.55492553
33AURKB1.43162793
34TBK11.41412900
35FES1.40518313
36JAK11.35580712
37BLK1.32173055
38MAP4K11.31575865
39HCK1.31065846
40TRPM71.30156722
41CDK71.29042597
42PIM21.27156289
43EIF2AK21.25986684
44RPS6KA41.23127718
45TXK1.21161789
46STK41.21105275
47CAMKK21.18362303
48NEK11.17761914
49FRK1.15880192
50CHEK21.15514758
51RPS6KB21.15281649
52MST41.11524752
53EPHA21.09808581
54BRD41.08989321
55TESK21.08930403
56PIK3CG1.08779229
57AKT31.08778788
58PIM11.08591357
59GRK71.08499995
60MAP3K121.07796245
61ERBB31.05536339
62PLK20.98558246
63TEC0.98437586
64PASK0.97515893
65MARK30.96443315
66CLK10.96123344
67AURKA0.94280066
68PRPF4B0.93900307
69KIT0.93625447
70TNK20.93520815
71JAK20.90960469
72CHEK10.90704296
73IRAK10.89186372
74CDK190.88585479
75BRAF0.87599474
76NUAK10.87440324
77MAP4K20.83434153
78MAP3K60.80023627
79TGFBR20.79191756
80IKBKB0.79067206
81STK100.78908939
82PBK0.76701237
83CSNK2A10.75940209
84CDK40.75719743
85ZAP700.74041183
86YES10.73495737
87MAP3K10.71359810
88MAP3K30.71251720
89MAP3K140.70251002
90ATM0.69658416
91PTK2B0.68476062
92NEK90.67137577
93PRKCQ0.66263726
94FGR0.65759027
95RPS6KA50.65582660
96ABL10.64291043
97MAP3K50.63855000
98PAK40.63398523
99CSNK2A20.63240834
100IRAK20.62657052
101BTK0.62540644
102MAP3K80.61649834
103CDK120.61300447
104TYK20.60710079
105CDK20.59855117
106MAP3K20.58956098
107CDK80.57582800
108BCKDK0.56583057
109LYN0.54480379
110MAPK110.52847954
111NEK60.52351360
112DYRK20.51467173
113MATK0.50467205
114LRRK20.49755827
115CDK30.49445364
116FGFR30.49387270
117OXSR10.48609819
118CDK10.47728338
119FLT30.47517078
120PDK10.47370020
121HIPK20.43286027
122CHUK0.43040087
123SYK0.42827424
124PAK10.42435365
125PRKCI0.41084626
126MAPKAPK30.40971525
127SIK30.40212054
128EPHB10.39659722
129MAPKAPK20.38658700
130GRK60.38314088
131MAPKAPK50.37472883
132TAOK20.36925051
133MAP3K110.36910993
134NME10.35714969
135PDK20.35099879
136BMPR1B0.34897906
137NLK0.34079263
138LCK0.31900724
139IGF1R0.31371110
140EGFR0.30858771
141ADRBK20.30509427
142GRK10.29607367
143RAF10.29397158
144IKBKE0.28294759
145MAP2K30.27544786
146CSF1R0.27521341
147MAP2K20.27417646
148TNIK0.26592605
149RPS6KA60.25956845
150KDR0.25264804
151JAK30.25022269
152MELK0.24612381
153CDK60.24143633
154PDK30.21484225

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.64714022
2Mismatch repair_Homo sapiens_hsa034304.02143649
3RNA polymerase_Homo sapiens_hsa030203.81985081
4Ribosome_Homo sapiens_hsa030103.81073082
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63307158
6Proteasome_Homo sapiens_hsa030503.38239806
7Homologous recombination_Homo sapiens_hsa034403.16703733
8Base excision repair_Homo sapiens_hsa034103.00287005
9Spliceosome_Homo sapiens_hsa030402.95375996
10Pyrimidine metabolism_Homo sapiens_hsa002402.81776985
11Type I diabetes mellitus_Homo sapiens_hsa049402.80915866
12Nucleotide excision repair_Homo sapiens_hsa034202.80614148
13Fanconi anemia pathway_Homo sapiens_hsa034602.68085276
14RNA transport_Homo sapiens_hsa030132.52948764
15Staphylococcus aureus infection_Homo sapiens_hsa051502.47213478
16Osteoclast differentiation_Homo sapiens_hsa043802.41322987
17Cell cycle_Homo sapiens_hsa041102.21228536
18Basal transcription factors_Homo sapiens_hsa030222.19135241
19Rheumatoid arthritis_Homo sapiens_hsa053232.14694831
20Non-homologous end-joining_Homo sapiens_hsa034502.14160650
21One carbon pool by folate_Homo sapiens_hsa006702.07687172
22T cell receptor signaling pathway_Homo sapiens_hsa046601.98580907
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90909709
24RNA degradation_Homo sapiens_hsa030181.88197607
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83305863
26Tuberculosis_Homo sapiens_hsa051521.76617338
27Viral myocarditis_Homo sapiens_hsa054161.73696790
28Purine metabolism_Homo sapiens_hsa002301.66500547
29Vitamin B6 metabolism_Homo sapiens_hsa007501.53750234
30Protein export_Homo sapiens_hsa030601.45605022
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44046650
32p53 signaling pathway_Homo sapiens_hsa041151.41212206
33TNF signaling pathway_Homo sapiens_hsa046681.37369955
34Toxoplasmosis_Homo sapiens_hsa051451.36492782
35Malaria_Homo sapiens_hsa051441.29450921
36Epstein-Barr virus infection_Homo sapiens_hsa051691.22948856
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16485145
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13961231
39Systemic lupus erythematosus_Homo sapiens_hsa053221.13824480
40Primary immunodeficiency_Homo sapiens_hsa053401.11568564
41mRNA surveillance pathway_Homo sapiens_hsa030151.10684170
42Herpes simplex infection_Homo sapiens_hsa051681.09823018
43Phagosome_Homo sapiens_hsa041451.04968652
44Folate biosynthesis_Homo sapiens_hsa007901.03330906
45Salmonella infection_Homo sapiens_hsa051320.95846719
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95844727
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94347596
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93518608
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93026806
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.91476313
51Antigen processing and presentation_Homo sapiens_hsa046120.91429713
52Lysosome_Homo sapiens_hsa041420.91121156
53Huntingtons disease_Homo sapiens_hsa050160.89376077
54Chemokine signaling pathway_Homo sapiens_hsa040620.86398171
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.84761524
56Acute myeloid leukemia_Homo sapiens_hsa052210.80963053
57African trypanosomiasis_Homo sapiens_hsa051430.80257083
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79800107
59Regulation of autophagy_Homo sapiens_hsa041400.77906135
60Pentose phosphate pathway_Homo sapiens_hsa000300.76270901
61Collecting duct acid secretion_Homo sapiens_hsa049660.75657828
62Oxidative phosphorylation_Homo sapiens_hsa001900.71423123
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.68515995
64Parkinsons disease_Homo sapiens_hsa050120.68076599
65Non-small cell lung cancer_Homo sapiens_hsa052230.68007428
66Viral carcinogenesis_Homo sapiens_hsa052030.67147120
67Prolactin signaling pathway_Homo sapiens_hsa049170.67108689
68Measles_Homo sapiens_hsa051620.66882844
69Hepatitis C_Homo sapiens_hsa051600.64908161
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.64574474
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62127326
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61793989
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60260261
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59015663
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.57878846
76Platelet activation_Homo sapiens_hsa046110.55303853
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52622823
78Sulfur relay system_Homo sapiens_hsa041220.52116831
79Selenocompound metabolism_Homo sapiens_hsa004500.51530371
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51118449
81Hematopoietic cell lineage_Homo sapiens_hsa046400.50910704
82Dorso-ventral axis formation_Homo sapiens_hsa043200.49931173
83Oocyte meiosis_Homo sapiens_hsa041140.47968022
84Glutathione metabolism_Homo sapiens_hsa004800.47590458
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.47205545
86mTOR signaling pathway_Homo sapiens_hsa041500.47096514
87Type II diabetes mellitus_Homo sapiens_hsa049300.46327701
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.46120141
89FoxO signaling pathway_Homo sapiens_hsa040680.45817740
90HTLV-I infection_Homo sapiens_hsa051660.45006219
91Vitamin digestion and absorption_Homo sapiens_hsa049770.44912199
92Arachidonic acid metabolism_Homo sapiens_hsa005900.44448948
93Legionellosis_Homo sapiens_hsa051340.43745580
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43431006
95Apoptosis_Homo sapiens_hsa042100.41733886
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.41509045
97Metabolic pathways_Homo sapiens_hsa011000.40649739
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.38376404
99Influenza A_Homo sapiens_hsa051640.38358147
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37805699
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37520461
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36203239
103Allograft rejection_Homo sapiens_hsa053300.35327484
104Graft-versus-host disease_Homo sapiens_hsa053320.34850093
105Pancreatic cancer_Homo sapiens_hsa052120.33401009
106Alcoholism_Homo sapiens_hsa050340.32607906
107Other glycan degradation_Homo sapiens_hsa005110.32402558
108Sulfur metabolism_Homo sapiens_hsa009200.32246607
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31563793
110Autoimmune thyroid disease_Homo sapiens_hsa053200.30839186
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29939165
112Insulin resistance_Homo sapiens_hsa049310.29344121
113Thyroid cancer_Homo sapiens_hsa052160.28999616
114Biosynthesis of amino acids_Homo sapiens_hsa012300.28976196
115N-Glycan biosynthesis_Homo sapiens_hsa005100.27517683
116Leishmaniasis_Homo sapiens_hsa051400.27165426
117Caffeine metabolism_Homo sapiens_hsa002320.26963869
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26895951
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.26747053
120Small cell lung cancer_Homo sapiens_hsa052220.24536847
121HIF-1 signaling pathway_Homo sapiens_hsa040660.24342395
122Fructose and mannose metabolism_Homo sapiens_hsa000510.23767173
123Linoleic acid metabolism_Homo sapiens_hsa005910.23215455
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.21872940
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21768283
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21735948
127Phototransduction_Homo sapiens_hsa047440.19256044
128Hepatitis B_Homo sapiens_hsa051610.18953962
129Chronic myeloid leukemia_Homo sapiens_hsa052200.17522025
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17115608
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17046878
132Alzheimers disease_Homo sapiens_hsa050100.16242883
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15954082
134Circadian rhythm_Homo sapiens_hsa047100.15861180
135Shigellosis_Homo sapiens_hsa051310.14907777
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14624263
137Sphingolipid metabolism_Homo sapiens_hsa006000.14578347
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14493773
139Tryptophan metabolism_Homo sapiens_hsa003800.14211060
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.13778785
141Asthma_Homo sapiens_hsa053100.11758035
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08085252
143B cell receptor signaling pathway_Homo sapiens_hsa046620.06756365
144Toll-like receptor signaling pathway_Homo sapiens_hsa046200.05166036
145MicroRNAs in cancer_Homo sapiens_hsa052060.04171531
146Pertussis_Homo sapiens_hsa051330.03697378

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