TRMT10A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)4.70935375
2axonemal dynein complex assembly (GO:0070286)4.44893947
3microtubule depolymerization (GO:0007019)4.41665290
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.40695760
5piRNA metabolic process (GO:0034587)4.18975759
6motile cilium assembly (GO:0044458)4.13685094
7centriole assembly (GO:0098534)3.83978667
8DNA methylation involved in gamete generation (GO:0043046)3.82759518
9centriole replication (GO:0007099)3.80390426
10regulation of mitotic spindle organization (GO:0060236)3.76448671
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.75885301
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.75885301
13NADH dehydrogenase complex assembly (GO:0010257)3.75885301
14regulation of meiosis I (GO:0060631)3.75729710
15maturation of SSU-rRNA (GO:0030490)3.66570542
16ATP synthesis coupled proton transport (GO:0015986)3.65634953
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.65634953
18mitochondrial respiratory chain complex assembly (GO:0033108)3.61312194
19protein complex biogenesis (GO:0070271)3.58159656
20regulation of spindle organization (GO:0090224)3.56133993
21DNA ligation (GO:0006266)3.54518537
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.52437366
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.47451505
24epithelial cilium movement (GO:0003351)3.46929660
25regulation of centriole replication (GO:0046599)3.45145800
26proteasome assembly (GO:0043248)3.45041972
27kinetochore organization (GO:0051383)3.44557212
28kinetochore assembly (GO:0051382)3.41170988
29regulation of DNA endoreduplication (GO:0032875)3.39963230
30fusion of sperm to egg plasma membrane (GO:0007342)3.36457076
31organelle disassembly (GO:1903008)3.35962937
32multicellular organism reproduction (GO:0032504)3.34848735
33ribonucleoprotein complex disassembly (GO:0032988)3.34713037
34ribosomal small subunit assembly (GO:0000028)3.33759909
35cilium movement (GO:0003341)3.28936997
36nuclear pore complex assembly (GO:0051292)3.28647377
37male meiosis (GO:0007140)3.23138724
38protein K6-linked ubiquitination (GO:0085020)3.22238439
39meiotic chromosome segregation (GO:0045132)3.20844795
40sperm-egg recognition (GO:0035036)3.18073825
41protein K11-linked ubiquitination (GO:0070979)3.15204869
42mitochondrial DNA replication (GO:0006264)3.14524237
43spindle checkpoint (GO:0031577)3.11674989
44retinal rod cell development (GO:0046548)3.11029816
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10876967
46tRNA methylation (GO:0030488)3.10737246
47cell wall macromolecule catabolic process (GO:0016998)3.09288396
48cell wall macromolecule metabolic process (GO:0044036)3.09288396
49mitotic spindle checkpoint (GO:0071174)3.08565430
50GTP biosynthetic process (GO:0006183)3.06880601
51transcription elongation from RNA polymerase I promoter (GO:0006362)3.06772142
52DNA-dependent DNA replication (GO:0006261)3.06590910
53respiratory electron transport chain (GO:0022904)3.06292245
54termination of RNA polymerase I transcription (GO:0006363)3.05675130
55termination of RNA polymerase III transcription (GO:0006386)3.04961331
56transcription elongation from RNA polymerase III promoter (GO:0006385)3.04961331
57chromatin remodeling at centromere (GO:0031055)3.04491113
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04388403
59CENP-A containing nucleosome assembly (GO:0034080)3.03657276
60nuclear pore organization (GO:0006999)3.03187712
61electron transport chain (GO:0022900)3.01674241
62respiratory chain complex IV assembly (GO:0008535)3.01196252
63mitotic chromosome condensation (GO:0007076)3.00990528
64cellular component biogenesis (GO:0044085)2.98593770
65male meiosis I (GO:0007141)2.97772575
66rRNA modification (GO:0000154)2.96848897
67DNA strand elongation (GO:0022616)2.95891485
68negative regulation of execution phase of apoptosis (GO:1900118)2.94948751
69mitotic spindle assembly checkpoint (GO:0007094)2.94446211
70microtubule polymerization or depolymerization (GO:0031109)2.94111425
71nucleotide-excision repair, DNA damage removal (GO:0000718)2.93478994
72DNA excision (GO:0044349)2.93478994
73S-adenosylmethionine metabolic process (GO:0046500)2.93423163
747-methylguanosine RNA capping (GO:0009452)2.92883267
75RNA capping (GO:0036260)2.92883267
76mitotic metaphase plate congression (GO:0007080)2.92671730
77spindle assembly checkpoint (GO:0071173)2.92587134
78ribosome assembly (GO:0042255)2.91858522
79negative regulation of mitotic sister chromatid separation (GO:2000816)2.91585685
80negative regulation of sister chromatid segregation (GO:0033046)2.91585685
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91585685
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91585685
83negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91585685
84synapsis (GO:0007129)2.91377378
85regulation of nuclear cell cycle DNA replication (GO:0033262)2.90386651
867-methylguanosine mRNA capping (GO:0006370)2.89811914
87negative regulation of DNA-dependent DNA replication (GO:2000104)2.88368093
88replication fork processing (GO:0031297)2.87085764
89DNA deamination (GO:0045006)2.86609589
90maturation of 5.8S rRNA (GO:0000460)2.85496683
91histone exchange (GO:0043486)2.84340538
92protein localization to kinetochore (GO:0034501)2.84231682
93transcription from mitochondrial promoter (GO:0006390)2.83738692
94ribosomal large subunit biogenesis (GO:0042273)2.83735930
95mitochondrial RNA metabolic process (GO:0000959)2.83556546
96negative regulation of chromosome segregation (GO:0051985)2.83407741
97sperm motility (GO:0030317)2.82167778
98binding of sperm to zona pellucida (GO:0007339)2.82012570
99metaphase plate congression (GO:0051310)2.81846217
100regulation of mitochondrial translation (GO:0070129)2.81510128
101intra-S DNA damage checkpoint (GO:0031573)2.80255281
102pseudouridine synthesis (GO:0001522)2.79150456
103mitotic recombination (GO:0006312)2.78614252
104transcription from RNA polymerase I promoter (GO:0006360)2.78179001
105acrosome reaction (GO:0007340)2.77661389
106pore complex assembly (GO:0046931)2.76864092
107negative regulation of translational initiation (GO:0045947)2.75514702
108regulation of sister chromatid segregation (GO:0033045)2.75391325
109regulation of mitotic sister chromatid separation (GO:0010965)2.75391325
110regulation of mitotic sister chromatid segregation (GO:0033047)2.75391325
111regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74974283
112regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74974283
113cell-cell recognition (GO:0009988)2.74897017
114attachment of spindle microtubules to kinetochore (GO:0008608)2.73519826
115rRNA methylation (GO:0031167)2.72418808
116UTP biosynthetic process (GO:0006228)2.72186114
117reciprocal meiotic recombination (GO:0007131)2.71265601
118reciprocal DNA recombination (GO:0035825)2.71265601
119chromosome organization involved in meiosis (GO:0070192)2.71165240
120regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69461281
121regulation of mitotic spindle checkpoint (GO:1903504)2.69461281
122regulation of development, heterochronic (GO:0040034)2.68582895
123DNA replication checkpoint (GO:0000076)2.68220575
124DNA replication initiation (GO:0006270)2.67635699
125spermatid development (GO:0007286)2.67542790
126transcription initiation from RNA polymerase I promoter (GO:0006361)2.63252928
127ribonucleoprotein complex biogenesis (GO:0022613)2.63110892
128transcription-coupled nucleotide-excision repair (GO:0006283)2.62751932
129regulation of cilium movement (GO:0003352)2.61936242
130RNA methylation (GO:0001510)2.61058616
131single strand break repair (GO:0000012)2.59494838
132telomere maintenance via semi-conservative replication (GO:0032201)2.59023114
133acrosome assembly (GO:0001675)2.58115520
134establishment of integrated proviral latency (GO:0075713)2.57660373
135ribosome biogenesis (GO:0042254)2.57589827
136DNA strand renaturation (GO:0000733)2.57527785
137telomere maintenance via recombination (GO:0000722)2.57225879
138meiotic nuclear division (GO:0007126)2.57152516
139DNA catabolic process, exonucleolytic (GO:0000738)2.56032974
140meiosis I (GO:0007127)2.55307107
141keratinocyte development (GO:0003334)2.55194776
142DNA damage response, detection of DNA damage (GO:0042769)2.53551853
143preassembly of GPI anchor in ER membrane (GO:0016254)2.51609490
144limb bud formation (GO:0060174)2.51285922
145regulation of timing of cell differentiation (GO:0048505)2.51116744
146DNA double-strand break processing (GO:0000729)2.50270101
147intraciliary transport (GO:0042073)2.49767152
148histone H2B ubiquitination (GO:0033523)2.48355233
149rRNA processing (GO:0006364)2.47750693
150DNA strand elongation involved in DNA replication (GO:0006271)2.47628924
151guanosine-containing compound biosynthetic process (GO:1901070)2.47504652
152pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.47469472
153meiotic cell cycle (GO:0051321)2.47332816
154response to X-ray (GO:0010165)2.47231528
155ribosomal small subunit biogenesis (GO:0042274)2.47122948
156exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.46157822
157tRNA modification (GO:0006400)2.46068341
158spliceosomal snRNP assembly (GO:0000387)2.43357789
159rRNA metabolic process (GO:0016072)2.43267607
160DNA replication-independent nucleosome organization (GO:0034724)2.42962032
161DNA replication-independent nucleosome assembly (GO:0006336)2.42962032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.77684984
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.89010294
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.65165912
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10283155
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83076329
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64493007
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.62354164
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.61480805
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56003481
10PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.52578758
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32597037
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.30495850
13PADI4_21655091_ChIP-ChIP_MCF-7_Human2.26689731
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.24388741
15VDR_22108803_ChIP-Seq_LS180_Human2.24153997
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.23027309
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10931212
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.07542856
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.04762082
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04099000
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03696257
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.99730915
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95905877
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95566853
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.95294966
26AR_21909140_ChIP-Seq_LNCAP_Human1.94871644
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90443474
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90075219
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82405292
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73601043
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73060540
32GABP_19822575_ChIP-Seq_HepG2_Human1.71974804
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71518300
34FUS_26573619_Chip-Seq_HEK293_Human1.70722999
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70032328
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.65177607
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.64697849
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62709269
39IRF1_19129219_ChIP-ChIP_H3396_Human1.61626134
40ZNF274_21170338_ChIP-Seq_K562_Hela1.61373282
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58772951
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58211837
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.57520559
44ELK1_19687146_ChIP-ChIP_HELA_Human1.55035465
45EWS_26573619_Chip-Seq_HEK293_Human1.54400148
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53819059
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.52369438
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51857735
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49067500
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48861330
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48648509
52SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47406769
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47335411
54EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.45793118
55VDR_23849224_ChIP-Seq_CD4+_Human1.45569735
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.45017701
57GBX2_23144817_ChIP-Seq_PC3_Human1.44858821
58STAT3_18555785_Chip-Seq_ESCs_Mouse1.43871785
59KDM5A_27292631_Chip-Seq_BREAST_Human1.43218048
60XRN2_22483619_ChIP-Seq_HELA_Human1.42755616
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.42468547
62RNF2_27304074_Chip-Seq_NSC_Mouse1.42166230
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41817560
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.40601649
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.39686454
66P300_18555785_Chip-Seq_ESCs_Mouse1.38641642
67P53_22387025_ChIP-Seq_ESCs_Mouse1.37561622
68MYC_18940864_ChIP-ChIP_HL60_Human1.37503088
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.36459853
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35373209
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34421638
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34318100
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.32936284
74OCT4_18555785_Chip-Seq_ESCs_Mouse1.32388906
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.31443189
76RUNX1_27457419_Chip-Seq_LIVER_Mouse1.30149841
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27085721
78FOXP3_21729870_ChIP-Seq_TREG_Human1.26430489
79TTF2_22483619_ChIP-Seq_HELA_Human1.26425464
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.26068970
81KLF4_18555785_Chip-Seq_ESCs_Mouse1.25673580
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25210804
83ZFX_18555785_Chip-Seq_ESCs_Mouse1.23237616
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23180172
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23118083
86KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22403401
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22059692
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22059692
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22059692
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21637023
91TAF15_26573619_Chip-Seq_HEK293_Human1.21256433
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20746629
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19999243
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.19737718
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.18964774
96CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18682865
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18522129
98ER_23166858_ChIP-Seq_MCF-7_Human1.17221763
99ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17193957
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.16001465
101FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15228403
102SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09228086
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.09200089
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07096639
105IGF1R_20145208_ChIP-Seq_DFB_Human1.07095118
106PU1_27457419_Chip-Seq_LIVER_Mouse1.06849433
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.06687279
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06284260
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04140524
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03598716
111MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02792590
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02713527
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02559408
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02475238
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01256564
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01219376
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00118236
118TFEB_21752829_ChIP-Seq_HELA_Human0.99750885
119ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99309036
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98967022
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98888724
122P300_19829295_ChIP-Seq_ESCs_Human0.98509534
123CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98478227
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98285423
125CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94135875
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93747920
127DCP1A_22483619_ChIP-Seq_HELA_Human0.93390527
128NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91687811
129ELF5_23300383_ChIP-Seq_T47D_Human0.85843642
130RBPJ_21746931_ChIP-Seq_IB4_Human0.85382804
131PHF8_20622853_ChIP-Seq_HELA_Human0.85284112
132FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84617103
133FOXA1_25329375_ChIP-Seq_VCAP_Human0.84617103
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84593980
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82035857
136CBP_20019798_ChIP-Seq_JUKART_Human0.82035857
137TP53_22573176_ChIP-Seq_HFKS_Human0.81045357
138FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80058053
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79673938
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79564242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.81186866
2MP0001188_hyperpigmentation3.29734549
3MP0008058_abnormal_DNA_repair3.23123215
4MP0005410_abnormal_fertilization3.20348424
5MP0006292_abnormal_olfactory_placode3.19152898
6MP0002102_abnormal_ear_morphology3.13812119
7MP0008057_abnormal_DNA_replication2.97597700
8MP0008877_abnormal_DNA_methylation2.86622579
9MP0000566_synostosis2.81348137
10MP0004147_increased_porphyrin_level2.71338306
11MP0003693_abnormal_embryo_hatching2.70500402
12MP0010094_abnormal_chromosome_stability2.66644791
13MP0003111_abnormal_nucleus_morphology2.40627930
14MP0005409_darkened_coat_color2.22065141
15MP0004381_abnormal_hair_follicle2.10410139
16MP0005408_hypopigmentation2.08346628
17MP0008932_abnormal_embryonic_tissue1.93649264
18MP0003077_abnormal_cell_cycle1.91998830
19MP0003941_abnormal_skin_development1.86395590
20MP0001727_abnormal_embryo_implantation1.86116043
21MP0003786_premature_aging1.84257121
22MP0000015_abnormal_ear_pigmentation1.83055052
23MP0002210_abnormal_sex_determination1.82730063
24MP0001929_abnormal_gametogenesis1.81961997
25MP0003698_abnormal_male_reproductive1.79408729
26MP0002938_white_spotting1.78903688
27MP0006035_abnormal_mitochondrial_morpho1.71361752
28MP0002277_abnormal_respiratory_mucosa1.70551122
29MP0004957_abnormal_blastocyst_morpholog1.63059016
30MP0003718_maternal_effect1.62564358
31MP0006036_abnormal_mitochondrial_physio1.56849137
32MP0009379_abnormal_foot_pigmentation1.56760177
33MP0008007_abnormal_cellular_replicative1.56230788
34MP0003806_abnormal_nucleotide_metabolis1.55269814
35MP0001661_extended_life_span1.50284674
36MP0008875_abnormal_xenobiotic_pharmacok1.47189130
37MP0001145_abnormal_male_reproductive1.46799902
38MP0005171_absent_coat_pigmentation1.46006428
39MP0003186_abnormal_redox_activity1.43963686
40MP0000049_abnormal_middle_ear1.43255878
41MP0005394_taste/olfaction_phenotype1.40775056
42MP0005499_abnormal_olfactory_system1.40775056
43MP0003937_abnormal_limbs/digits/tail_de1.40527294
44MP0005075_abnormal_melanosome_morpholog1.39564812
45MP0005360_urolithiasis1.34447898
46MP0009697_abnormal_copulation1.34206260
47MP0002249_abnormal_larynx_morphology1.33755827
48MP0001764_abnormal_homeostasis1.33243811
49MP0001986_abnormal_taste_sensitivity1.33210902
50MP0002160_abnormal_reproductive_system1.32814402
51MP0000569_abnormal_digit_pigmentation1.31744558
52MP0005551_abnormal_eye_electrophysiolog1.31047853
53MP0000427_abnormal_hair_cycle1.30785598
54MP0009250_abnormal_appendicular_skeleto1.28724485
55MP0002234_abnormal_pharynx_morphology1.27756537
56MP0000653_abnormal_sex_gland1.26859626
57MP0004742_abnormal_vestibular_system1.26062375
58MP0003938_abnormal_ear_development1.24775451
59MP0003315_abnormal_perineum_morphology1.23423337
60MP0005248_abnormal_Harderian_gland1.18931722
61MP0004133_heterotaxia1.18130931
62MP0002090_abnormal_vision1.16391174
63MP0003950_abnormal_plasma_membrane1.14308693
64MP0002638_abnormal_pupillary_reflex1.12327738
65MP0001697_abnormal_embryo_size1.12103839
66MP0000026_abnormal_inner_ear1.10204415
67MP0003787_abnormal_imprinting1.09359362
68MP0003121_genomic_imprinting1.07515954
69MP0005389_reproductive_system_phenotype1.07299711
70MP0002095_abnormal_skin_pigmentation1.07236744
71MP0000762_abnormal_tongue_morphology1.05919414
72MP0002177_abnormal_outer_ear1.05483666
73MP0005174_abnormal_tail_pigmentation1.04713821
74MP0004885_abnormal_endolymph1.03981171
75MP0005187_abnormal_penis_morphology1.03641956
76MP0001293_anophthalmia1.01859156
77MP0002132_abnormal_respiratory_system1.01645139
78MP0002653_abnormal_ependyma_morphology1.01628776
79MP0008995_early_reproductive_senescence1.01120643
80MP0005645_abnormal_hypothalamus_physiol1.00887182
81MP0002084_abnormal_developmental_patter1.00439094
82MP0003878_abnormal_ear_physiology0.97976107
83MP0005377_hearing/vestibular/ear_phenot0.97976107
84MP0003755_abnormal_palate_morphology0.97126229
85MP0010030_abnormal_orbit_morphology0.96861558
86MP0002233_abnormal_nose_morphology0.95252199
87MP0002161_abnormal_fertility/fecundity0.94606783
88MP0002736_abnormal_nociception_after0.94187423
89MP0001286_abnormal_eye_development0.93599933
90MP0005451_abnormal_body_composition0.93364986
91MP0003890_abnormal_embryonic-extraembry0.93287049
92MP0002163_abnormal_gland_morphology0.92467403
93MP0005379_endocrine/exocrine_gland_phen0.92192400
94MP0001324_abnormal_eye_pigmentation0.91536828
95MP0000358_abnormal_cell_content/0.89695000
96MP0008260_abnormal_autophagy0.89491569
97MP0000432_abnormal_head_morphology0.88795688
98MP0000383_abnormal_hair_follicle0.88176844
99MP0004142_abnormal_muscle_tone0.86766433
100MP0001119_abnormal_female_reproductive0.86742483
101MP0006072_abnormal_retinal_apoptosis0.85917551
102MP0003123_paternal_imprinting0.84405799
103MP0002751_abnormal_autonomic_nervous0.83292367
104MP0001529_abnormal_vocalization0.83168555
105MP0002116_abnormal_craniofacial_bone0.82888071
106MP0004043_abnormal_pH_regulation0.82738458
107MP0000350_abnormal_cell_proliferation0.82085106
108MP0002282_abnormal_trachea_morphology0.81615616
109MP0001963_abnormal_hearing_physiology0.80747032
110MP0001346_abnormal_lacrimal_gland0.80559027
111MP0000613_abnormal_salivary_gland0.80131580
112MP0000631_abnormal_neuroendocrine_gland0.80073176
113MP0005253_abnormal_eye_physiology0.79565574
114MP0008789_abnormal_olfactory_epithelium0.79184943
115MP0002085_abnormal_embryonic_tissue0.79062104
116MP0001485_abnormal_pinna_reflex0.79031673
117MP0001186_pigmentation_phenotype0.77792123
118MP0002697_abnormal_eye_size0.77039448
119MP0005380_embryogenesis_phenotype0.75690721
120MP0001672_abnormal_embryogenesis/_devel0.75690721
121MP0003385_abnormal_body_wall0.74249959
122MP0000462_abnormal_digestive_system0.73614777
123MP0001919_abnormal_reproductive_system0.73407267
124MP0001984_abnormal_olfaction0.71257566
125MP0000313_abnormal_cell_death0.70252384
126MP0000372_irregular_coat_pigmentation0.70121545
127MP0002109_abnormal_limb_morphology0.69957140
128MP0002114_abnormal_axial_skeleton0.69515308
129MP0003936_abnormal_reproductive_system0.68289292
130MP0000647_abnormal_sebaceous_gland0.67862081
131MP0001873_stomach_inflammation0.67016864
132MP0008872_abnormal_physiological_respon0.66889068
133MP0005391_vision/eye_phenotype0.64563545
134MP0002080_prenatal_lethality0.64399080
135MP0001730_embryonic_growth_arrest0.64349952
136MP0002752_abnormal_somatic_nervous0.64143216
137MP0000678_abnormal_parathyroid_gland0.63084524
138MP0002111_abnormal_tail_morphology0.61668956
139MP0000490_abnormal_crypts_of0.60697662

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.47943990
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.26297422
3Absent/shortened dynein arms (HP:0200106)5.26297422
4Abnormal respiratory epithelium morphology (HP:0012253)4.30517361
5Abnormal respiratory motile cilium morphology (HP:0005938)4.30517361
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.28596988
7Abnormal ciliary motility (HP:0012262)4.27139823
8Acute necrotizing encephalopathy (HP:0006965)4.25112574
9Abnormal respiratory motile cilium physiology (HP:0012261)4.19507323
10Increased CSF lactate (HP:0002490)3.97380246
11Chromsome breakage (HP:0040012)3.96292702
12Abnormal mitochondria in muscle tissue (HP:0008316)3.74764469
13Acute encephalopathy (HP:0006846)3.72550827
14Mitochondrial inheritance (HP:0001427)3.69767022
15Progressive macrocephaly (HP:0004481)3.50206493
16Increased hepatocellular lipid droplets (HP:0006565)3.40948911
17Gonadotropin excess (HP:0000837)3.35433369
18Supernumerary spleens (HP:0009799)3.30770828
19Septo-optic dysplasia (HP:0100842)3.24446135
20Lipid accumulation in hepatocytes (HP:0006561)3.18636749
21Hepatocellular necrosis (HP:0001404)3.16826956
22Rhinitis (HP:0012384)3.04389765
23Short middle phalanx of the 5th finger (HP:0004220)2.99332046
24Duplicated collecting system (HP:0000081)2.96905538
25Hepatic necrosis (HP:0002605)2.96833362
26Cerebral edema (HP:0002181)2.95550503
27Birth length less than 3rd percentile (HP:0003561)2.90147748
28Tubulointerstitial nephritis (HP:0001970)2.82790733
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.80552320
30Abnormal protein N-linked glycosylation (HP:0012347)2.80552320
31Abnormal protein glycosylation (HP:0012346)2.80552320
32Abnormal glycosylation (HP:0012345)2.80552320
33Meckel diverticulum (HP:0002245)2.78050008
34Aplastic anemia (HP:0001915)2.77670692
35Ectopic kidney (HP:0000086)2.72655888
36Exertional dyspnea (HP:0002875)2.68992971
37Nephronophthisis (HP:0000090)2.67830667
38Abnormality of the renal collecting system (HP:0004742)2.67186256
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.66370503
40Increased serum lactate (HP:0002151)2.64614521
41Abnormality of the ileum (HP:0001549)2.64543161
42Abnormality of the preputium (HP:0100587)2.61027072
43Abnormality of alanine metabolism (HP:0010916)2.58449909
44Hyperalaninemia (HP:0003348)2.58449909
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58449909
46Absent septum pellucidum (HP:0001331)2.54496625
47Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.48235555
48Optic nerve hypoplasia (HP:0000609)2.47184283
49Abnormality of the septum pellucidum (HP:0007375)2.44802011
50Reticulocytopenia (HP:0001896)2.42235138
51Upper limb muscle weakness (HP:0003484)2.41537064
52True hermaphroditism (HP:0010459)2.38635586
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.38289925
54Absent radius (HP:0003974)2.37340102
55Macrocytic anemia (HP:0001972)2.35444720
56Nephroblastoma (Wilms tumor) (HP:0002667)2.35097982
57Duplication of thumb phalanx (HP:0009942)2.32806480
58Abnormality of chromosome stability (HP:0003220)2.32216364
59Reduced antithrombin III activity (HP:0001976)2.31405329
60Abnormality of cells of the erythroid lineage (HP:0012130)2.31376105
61Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.31367208
62Aplasia involving forearm bones (HP:0009822)2.31132628
63Absent forearm bone (HP:0003953)2.31132628
64Respiratory failure (HP:0002878)2.31000060
65Renal Fanconi syndrome (HP:0001994)2.30516109
66Abnormal lung lobation (HP:0002101)2.27464196
67Median cleft lip (HP:0000161)2.26632077
68Embryonal renal neoplasm (HP:0011794)2.26399210
69Asplenia (HP:0001746)2.26186747
70Breast hypoplasia (HP:0003187)2.24917989
71Lactic acidosis (HP:0003128)2.24566262
72Medial flaring of the eyebrow (HP:0010747)2.24509653
73Triphalangeal thumb (HP:0001199)2.24398809
74Abnormality of the renal medulla (HP:0100957)2.22550623
75Pancreatic fibrosis (HP:0100732)2.20951402
76Intestinal atresia (HP:0011100)2.20868110
77Preaxial hand polydactyly (HP:0001177)2.19224930
78Abnormal number of erythroid precursors (HP:0012131)2.17268095
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16789848
80Pancreatic cysts (HP:0001737)2.16545656
81Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.15901248
82Increased serum pyruvate (HP:0003542)2.13834942
83Impulsivity (HP:0100710)2.12242829
84Leukodystrophy (HP:0002415)2.12208865
85Postaxial foot polydactyly (HP:0001830)2.08227660
86Volvulus (HP:0002580)2.06657621
87Absent thumb (HP:0009777)2.06540143
88Duodenal stenosis (HP:0100867)2.05690780
89Small intestinal stenosis (HP:0012848)2.05690780
90Microretrognathia (HP:0000308)2.04919668
91Aplasia cutis congenita (HP:0001057)2.04570340
92Abnormality of the phalanges of the 5th finger (HP:0004213)2.03752258
93Abnormality of midbrain morphology (HP:0002418)2.02251813
94Molar tooth sign on MRI (HP:0002419)2.02251813
95Microvesicular hepatic steatosis (HP:0001414)2.02029431
96Lethargy (HP:0001254)2.01441475
97CNS demyelination (HP:0007305)1.98547935
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.97953594
99Acanthocytosis (HP:0001927)1.96790770
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95746469
101Myelodysplasia (HP:0002863)1.93995887
102Congenital, generalized hypertrichosis (HP:0004540)1.93721382
103Colon cancer (HP:0003003)1.92694056
104Abnormality of DNA repair (HP:0003254)1.91964798
105X-linked dominant inheritance (HP:0001423)1.90153063
106Facial cleft (HP:0002006)1.89528734
107Abnormality of the duodenum (HP:0002246)1.88851814
1083-Methylglutaconic aciduria (HP:0003535)1.87355087
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86959274
110Abnormality of methionine metabolism (HP:0010901)1.86815070
111Abnormality of glycolysis (HP:0004366)1.86453586
112Anencephaly (HP:0002323)1.86037706
113Aplasia/hypoplasia of the uterus (HP:0008684)1.84212377
114Adrenal hypoplasia (HP:0000835)1.83657485
115Exercise intolerance (HP:0003546)1.83305067
11611 pairs of ribs (HP:0000878)1.82873566
117Sex reversal (HP:0012245)1.82300014
118Abnormal sex determination (HP:0012244)1.82300014
119Optic disc pallor (HP:0000543)1.82227008
120Proximal tubulopathy (HP:0000114)1.81936376
121Bone marrow hypocellularity (HP:0005528)1.81186924
122Abnormality of serum amino acid levels (HP:0003112)1.81072257
123Clubbing of toes (HP:0100760)1.79756746
124Sloping forehead (HP:0000340)1.79504016
125Fibular hypoplasia (HP:0003038)1.78541695
126Type I transferrin isoform profile (HP:0003642)1.78155599
127Oculomotor apraxia (HP:0000657)1.77676982
128Genital tract atresia (HP:0001827)1.77594777
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.77278174
130Congenital hepatic fibrosis (HP:0002612)1.76512758
131Male pseudohermaphroditism (HP:0000037)1.75982850
132Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75972328
133Submucous cleft hard palate (HP:0000176)1.75910096
134Horseshoe kidney (HP:0000085)1.75639957
135Increased intramyocellular lipid droplets (HP:0012240)1.74948478
136Patchy hypopigmentation of hair (HP:0011365)1.74867942
137Abnormality of incisor morphology (HP:0011063)1.74170673
138Bronchiectasis (HP:0002110)1.73238442
139White forelock (HP:0002211)1.72674319
140Respiratory difficulties (HP:0002880)1.72340443
141Chronic bronchitis (HP:0004469)1.71930814
142Congenital primary aphakia (HP:0007707)1.71829507
143Short tibia (HP:0005736)1.71773191
144Attenuation of retinal blood vessels (HP:0007843)1.71562940
145Astigmatism (HP:0000483)1.69548383
146Hypoplasia of the radius (HP:0002984)1.68549827
147Abnormality of abdominal situs (HP:0011620)1.67703290
148Abdominal situs inversus (HP:0003363)1.67703290
149Short thumb (HP:0009778)1.67586856
150Aganglionic megacolon (HP:0002251)1.66929792
151Renal agenesis (HP:0000104)1.66460564
152Nephrogenic diabetes insipidus (HP:0009806)1.64520690
153Irregular epiphyses (HP:0010582)1.63121285
154Gait imbalance (HP:0002141)1.61288931
155Abnormality of secondary sexual hair (HP:0009888)1.59563591
156Abnormality of the axillary hair (HP:0100134)1.59563591
157Partial duplication of thumb phalanx (HP:0009944)1.58155198
158Recurrent sinusitis (HP:0011108)1.57704613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.57405000
2CASK3.46218709
3MKNK23.01623470
4TIE12.65663405
5MKNK12.62534980
6SRPK12.57944490
7ZAK2.49913403
8CDK92.35311772
9BUB12.15975717
10TLK12.14306082
11WEE12.12506916
12VRK11.99746090
13VRK21.95099507
14IRAK31.79534654
15EIF2AK21.79370527
16PLK41.75930782
17TTK1.74665000
18PNCK1.73722208
19TNIK1.71497198
20GRK11.70075822
21PBK1.67729071
22NEK11.61060134
23YES11.57108363
24TRIM281.55108000
25AKT31.54743350
26BLK1.54483591
27CDC71.54382624
28NUAK11.49562979
29TAF11.46798482
30NEK61.45902415
31EIF2AK11.43590902
32PLK31.38914397
33ACVR1B1.34219833
34CLK11.30505604
35WNK31.30238448
36PLK11.24183348
37STK38L1.22162570
38TSSK61.19504304
39IRAK41.18910378
40TEC1.18241297
41CHEK21.17921040
42STK391.17825450
43NEK21.15563849
44TXK1.13072855
45EPHA31.11816185
46NME21.08893694
47BRSK21.06392700
48EIF2AK31.03183642
49CDK71.02159784
50CDK31.02037721
51PKN10.96080037
52ADRBK20.95660252
53ERBB30.94577849
54EPHA20.93913790
55PDK20.93896032
56BMPR1B0.92227696
57BMPR20.89580916
58SIK30.87414733
59ATR0.86468568
60MAPK150.85015599
61BCR0.84035022
62BRSK10.80200578
63FRK0.78919764
64AURKB0.78471320
65MAP3K140.78291104
66CDK80.77842234
67PDK40.77488025
68PDK30.77488025
69DYRK20.77005522
70IRAK10.76706066
71PASK0.75640638
72CDK120.74634942
73STK30.74441336
74RPS6KA50.73237814
75DYRK30.72613430
76MAP3K40.70837666
77ATM0.68974165
78MAP3K120.67845997
79MST40.67730467
80CHEK10.67339942
81GRK70.65585769
82CCNB10.62756835
83AURKA0.62050924
84MAP2K70.61849883
85TGFBR10.59830838
86NLK0.58954375
87WNK40.58616714
88CSNK1E0.57448042
89EPHB20.56929734
90CSNK2A10.54920326
91MUSK0.54600516
92MAPK130.53357992
93STK40.52833990
94OXSR10.50968905
95CSNK2A20.50071284
96LATS10.49347973
97IKBKB0.47377563
98PIK3CG0.47141828
99MARK30.46685926
100PLK20.45638502
101CAMK1G0.44315407
102STK240.43880998
103PRKCG0.43528560
104PRKCI0.43247553
105CDK60.42813472
106CDK10.42359971
107BRD40.41778026
108IRAK20.39964918
109PIM20.39074307
110INSRR0.38752403
111FGR0.37547297
112CDK190.36774768
113MAP4K20.34604963
114DDR20.34442001
115PRKCE0.34242421
116PIM10.34054549
117NME10.33381040
118CDK20.33314115
119RPS6KB20.32289209
120TAOK30.31987730
121MELK0.31220211
122RPS6KA40.31200803
123MAPKAPK50.31019421
124BRAF0.30795815
125MAPKAPK30.29757378
126CSNK1G10.28428275
127RPS6KB10.24437395
128PRKACB0.24382586
129ERBB40.23563580
130MINK10.21903413

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.37977272
2RNA polymerase_Homo sapiens_hsa030203.37695011
3Homologous recombination_Homo sapiens_hsa034403.20633769
4Mismatch repair_Homo sapiens_hsa034303.13725536
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08416515
6DNA replication_Homo sapiens_hsa030302.94319646
7Basal transcription factors_Homo sapiens_hsa030222.82631058
8Ribosome_Homo sapiens_hsa030102.81267047
9Proteasome_Homo sapiens_hsa030502.72393989
10Spliceosome_Homo sapiens_hsa030402.52023013
11Nucleotide excision repair_Homo sapiens_hsa034202.50396246
12Non-homologous end-joining_Homo sapiens_hsa034502.23947169
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19652771
14Pyrimidine metabolism_Homo sapiens_hsa002402.15342783
15RNA transport_Homo sapiens_hsa030132.07623262
16Protein export_Homo sapiens_hsa030601.92496334
17Cell cycle_Homo sapiens_hsa041101.90455300
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90027169
19Base excision repair_Homo sapiens_hsa034101.88738507
20RNA degradation_Homo sapiens_hsa030181.85634290
21Selenocompound metabolism_Homo sapiens_hsa004501.73856592
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67082569
23Purine metabolism_Homo sapiens_hsa002301.62420851
24Vitamin B6 metabolism_Homo sapiens_hsa007501.58029706
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51980572
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48274069
27Propanoate metabolism_Homo sapiens_hsa006401.46704192
28One carbon pool by folate_Homo sapiens_hsa006701.45514826
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41756023
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36360969
31Arachidonic acid metabolism_Homo sapiens_hsa005901.32695711
32Pyruvate metabolism_Homo sapiens_hsa006201.30790859
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27569478
34mRNA surveillance pathway_Homo sapiens_hsa030151.22071881
35Autoimmune thyroid disease_Homo sapiens_hsa053201.19364149
36Sphingolipid metabolism_Homo sapiens_hsa006001.18673642
37Caffeine metabolism_Homo sapiens_hsa002321.17546237
38p53 signaling pathway_Homo sapiens_hsa041151.14222759
39Ether lipid metabolism_Homo sapiens_hsa005651.13346992
40Butanoate metabolism_Homo sapiens_hsa006501.12993538
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11044004
42Huntingtons disease_Homo sapiens_hsa050161.08233404
43Linoleic acid metabolism_Homo sapiens_hsa005911.06348662
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.06269701
45Phototransduction_Homo sapiens_hsa047441.05983110
46Chemical carcinogenesis_Homo sapiens_hsa052041.01661886
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95818065
48Oxidative phosphorylation_Homo sapiens_hsa001900.94364044
49Cardiac muscle contraction_Homo sapiens_hsa042600.93770896
50Tryptophan metabolism_Homo sapiens_hsa003800.93397076
51Systemic lupus erythematosus_Homo sapiens_hsa053220.92986232
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92430047
53Epstein-Barr virus infection_Homo sapiens_hsa051690.91278908
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86069756
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85085707
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83893174
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81267156
58Primary immunodeficiency_Homo sapiens_hsa053400.80806055
59Allograft rejection_Homo sapiens_hsa053300.80799278
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80451352
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.79898123
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79744964
63Graft-versus-host disease_Homo sapiens_hsa053320.79470949
64Basal cell carcinoma_Homo sapiens_hsa052170.79056637
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78158406
66Fatty acid elongation_Homo sapiens_hsa000620.77708521
67Asthma_Homo sapiens_hsa053100.76813855
68Hematopoietic cell lineage_Homo sapiens_hsa046400.75597280
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73514136
70Hedgehog signaling pathway_Homo sapiens_hsa043400.72559866
71Nitrogen metabolism_Homo sapiens_hsa009100.71596913
72N-Glycan biosynthesis_Homo sapiens_hsa005100.71400201
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71338225
74Herpes simplex infection_Homo sapiens_hsa051680.70842145
75Peroxisome_Homo sapiens_hsa041460.70342955
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.69257143
77beta-Alanine metabolism_Homo sapiens_hsa004100.68785112
78Vitamin digestion and absorption_Homo sapiens_hsa049770.66822262
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65061198
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63416812
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63018367
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60608157
83Lysine degradation_Homo sapiens_hsa003100.60124993
84Rheumatoid arthritis_Homo sapiens_hsa053230.59219537
85Fatty acid degradation_Homo sapiens_hsa000710.58802656
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57711291
87Parkinsons disease_Homo sapiens_hsa050120.57613416
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57238842
89Thyroid cancer_Homo sapiens_hsa052160.56917364
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55613184
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.53840353
92Wnt signaling pathway_Homo sapiens_hsa043100.53539937
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.53394183
94Steroid biosynthesis_Homo sapiens_hsa001000.53024720
95TGF-beta signaling pathway_Homo sapiens_hsa043500.51323663
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.49978159
97Antigen processing and presentation_Homo sapiens_hsa046120.48473758
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46311193
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46231465
100Viral carcinogenesis_Homo sapiens_hsa052030.42934001
101Measles_Homo sapiens_hsa051620.42872973
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42456359
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42176933
104Regulation of autophagy_Homo sapiens_hsa041400.42083723
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.42019655
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41550873
107Carbon metabolism_Homo sapiens_hsa012000.40574604
108Taste transduction_Homo sapiens_hsa047420.40377801
109Oocyte meiosis_Homo sapiens_hsa041140.39461390
110Sulfur metabolism_Homo sapiens_hsa009200.39347563
111Collecting duct acid secretion_Homo sapiens_hsa049660.39344989
112Glutathione metabolism_Homo sapiens_hsa004800.38678285
113HTLV-I infection_Homo sapiens_hsa051660.38538691
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38421881
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38130112
116Arginine and proline metabolism_Homo sapiens_hsa003300.38088556
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37696209
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36955742
119Alcoholism_Homo sapiens_hsa050340.36851426
120Metabolic pathways_Homo sapiens_hsa011000.36806815
121Fatty acid metabolism_Homo sapiens_hsa012120.35746110
122Serotonergic synapse_Homo sapiens_hsa047260.35282096
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31917821
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30919117
125MicroRNAs in cancer_Homo sapiens_hsa052060.29846189
126Folate biosynthesis_Homo sapiens_hsa007900.29639065
127Melanoma_Homo sapiens_hsa052180.28977161
128Malaria_Homo sapiens_hsa051440.28280771
129Alzheimers disease_Homo sapiens_hsa050100.27916097
130Nicotine addiction_Homo sapiens_hsa050330.27599052
131Fat digestion and absorption_Homo sapiens_hsa049750.27529574
132Tyrosine metabolism_Homo sapiens_hsa003500.27120078
133Hippo signaling pathway_Homo sapiens_hsa043900.25522738
134Retinol metabolism_Homo sapiens_hsa008300.25077003
135Mineral absorption_Homo sapiens_hsa049780.24907216
136Other glycan degradation_Homo sapiens_hsa005110.24319125
137Pathways in cancer_Homo sapiens_hsa052000.23502916
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23409005
139Axon guidance_Homo sapiens_hsa043600.23254702
140Histidine metabolism_Homo sapiens_hsa003400.22189340
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19790391
142Ras signaling pathway_Homo sapiens_hsa040140.19032897
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17455987
144Biosynthesis of amino acids_Homo sapiens_hsa012300.14527983

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