TRMT10C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.08395626
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.77008314
3chaperone-mediated protein transport (GO:0072321)4.62536272
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.59886732
5maturation of SSU-rRNA (GO:0030490)4.50999943
6establishment of integrated proviral latency (GO:0075713)4.41976882
7ribosomal large subunit biogenesis (GO:0042273)4.37094900
8purine nucleobase biosynthetic process (GO:0009113)4.34630490
9nucleobase biosynthetic process (GO:0046112)4.26729519
10translational termination (GO:0006415)4.10890414
11CENP-A containing nucleosome assembly (GO:0034080)4.10791994
12viral transcription (GO:0019083)4.06794978
13chromatin remodeling at centromere (GO:0031055)4.04049086
14ATP synthesis coupled proton transport (GO:0015986)4.02497833
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02497833
16mitotic metaphase plate congression (GO:0007080)4.01653405
17ribonucleoprotein complex biogenesis (GO:0022613)3.99547252
18ribosome biogenesis (GO:0042254)3.98242641
19formation of translation preinitiation complex (GO:0001731)3.98143342
20IMP biosynthetic process (GO:0006188)3.94202464
21DNA strand elongation involved in DNA replication (GO:0006271)3.93918887
22DNA deamination (GO:0045006)3.93037570
23DNA double-strand break processing (GO:0000729)3.87554407
24ribosome assembly (GO:0042255)3.84243789
25folic acid-containing compound biosynthetic process (GO:0009396)3.81869703
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.80734747
27telomere maintenance via semi-conservative replication (GO:0032201)3.79044064
28ribosomal small subunit biogenesis (GO:0042274)3.78737589
29DNA replication initiation (GO:0006270)3.78101917
30translational elongation (GO:0006414)3.74706520
31DNA strand elongation (GO:0022616)3.73706896
32DNA unwinding involved in DNA replication (GO:0006268)3.73254468
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72276275
34cullin deneddylation (GO:0010388)3.72216420
35metaphase plate congression (GO:0051310)3.67846716
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65644400
37protein localization to kinetochore (GO:0034501)3.65450747
38translational initiation (GO:0006413)3.63556964
39DNA replication checkpoint (GO:0000076)3.63248482
40DNA damage response, detection of DNA damage (GO:0042769)3.61530284
41kinetochore organization (GO:0051383)3.61009774
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.60335134
43negative regulation of ligase activity (GO:0051352)3.60335134
44DNA replication-independent nucleosome assembly (GO:0006336)3.58741173
45DNA replication-independent nucleosome organization (GO:0034724)3.58741173
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57403575
47IMP metabolic process (GO:0046040)3.56584689
48regulation of helicase activity (GO:0051095)3.52912909
49rRNA processing (GO:0006364)3.51876181
50protein deneddylation (GO:0000338)3.48710715
51mitochondrial respiratory chain complex assembly (GO:0033108)3.48089192
52pseudouridine synthesis (GO:0001522)3.46765247
53cotranslational protein targeting to membrane (GO:0006613)3.46348204
54telomere maintenance via recombination (GO:0000722)3.45293222
55protein targeting to ER (GO:0045047)3.45281143
56protein targeting to mitochondrion (GO:0006626)3.44604773
57respiratory electron transport chain (GO:0022904)3.42657658
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41564908
59regulation of mitotic spindle checkpoint (GO:1903504)3.41564908
60rRNA metabolic process (GO:0016072)3.38517607
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37392671
62transcription from mitochondrial promoter (GO:0006390)3.37202487
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36917658
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.36917658
65NADH dehydrogenase complex assembly (GO:0010257)3.36917658
66establishment of viral latency (GO:0019043)3.36719259
67mitotic nuclear envelope disassembly (GO:0007077)3.36218276
68nuclear pore organization (GO:0006999)3.35977485
69mitotic recombination (GO:0006312)3.35152394
70protein complex biogenesis (GO:0070271)3.34654654
71electron transport chain (GO:0022900)3.34355657
72histone exchange (GO:0043486)3.32502474
73DNA ligation (GO:0006266)3.32260211
74rRNA modification (GO:0000154)3.32009611
75protein localization to mitochondrion (GO:0070585)3.30400456
76protein localization to endoplasmic reticulum (GO:0070972)3.29695076
77kinetochore assembly (GO:0051382)3.28796596
78establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26464622
79DNA catabolic process, exonucleolytic (GO:0000738)3.24739934
80respiratory chain complex IV assembly (GO:0008535)3.23020133
81protein neddylation (GO:0045116)3.22415623
82attachment of spindle microtubules to kinetochore (GO:0008608)3.21159762
83establishment of protein localization to mitochondrion (GO:0072655)3.21117112
84telomere maintenance via telomere lengthening (GO:0010833)3.20474007
85cellular protein complex disassembly (GO:0043624)3.20409869
86maturation of 5.8S rRNA (GO:0000460)3.17183699
87regulation of spindle organization (GO:0090224)3.16644570
88viral mRNA export from host cell nucleus (GO:0046784)3.16351092
89viral life cycle (GO:0019058)3.15633272
90DNA replication-dependent nucleosome assembly (GO:0006335)3.15086507
91DNA replication-dependent nucleosome organization (GO:0034723)3.15086507
92nuclear pore complex assembly (GO:0051292)3.13728745
93histone mRNA metabolic process (GO:0008334)3.13410483
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12520995
95cellular component biogenesis (GO:0044085)3.12285704
96regulation of cellular amino acid metabolic process (GO:0006521)3.12024385
97protein localization to chromosome, centromeric region (GO:0071459)3.10341696
98spliceosomal snRNP assembly (GO:0000387)3.09856037
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09315283
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08876559
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08748668
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08748668
103signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08748668
104establishment of chromosome localization (GO:0051303)3.07247274
105membrane disassembly (GO:0030397)3.06754376
106nuclear envelope disassembly (GO:0051081)3.06754376
107replication fork processing (GO:0031297)3.05555083
108signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05324868
109intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05324868
110negative regulation of sister chromatid segregation (GO:0033046)3.04565945
111negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04565945
112translation (GO:0006412)3.04426171
113folic acid metabolic process (GO:0046655)2.91463896
114mitotic chromosome condensation (GO:0007076)2.88850319
115rRNA methylation (GO:0031167)2.86016539
116protein complex disassembly (GO:0043241)2.84611153
117nuclear-transcribed mRNA catabolic process (GO:0000956)2.83682606
118meiotic chromosome segregation (GO:0045132)2.83156869
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.81906413
120termination of RNA polymerase III transcription (GO:0006386)2.81900795
121transcription elongation from RNA polymerase III promoter (GO:0006385)2.81900795
122proteasome assembly (GO:0043248)2.80018780
123anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75014636
124macromolecular complex disassembly (GO:0032984)2.73568538
125transcription-coupled nucleotide-excision repair (GO:0006283)2.73468698
126termination of RNA polymerase I transcription (GO:0006363)2.73041531
127somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71968683
128somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71968683
129isotype switching (GO:0045190)2.71968683
130negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71353278
131pteridine-containing compound biosynthetic process (GO:0042559)2.70895558
132chromatin assembly or disassembly (GO:0006333)2.70612995
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70330234
134regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70252850
135* ncRNA processing (GO:0034470)2.69509079
136mRNA catabolic process (GO:0006402)2.69230824
137tRNA methylation (GO:0030488)2.68696919
138positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67814005
139pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.67698919
140transcription elongation from RNA polymerase I promoter (GO:0006362)2.67183822
141G1/S transition of mitotic cell cycle (GO:0000082)2.66730207
142cell cycle G1/S phase transition (GO:0044843)2.66730207
143RNA catabolic process (GO:0006401)2.65307822
144somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64771703
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.64771703
146regulation of mitochondrial translation (GO:0070129)2.63826551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.23305728
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.47064568
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55114168
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42859970
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.34767242
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25709243
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.08973080
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.99334179
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95186088
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90021701
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85591313
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83135851
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81202396
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.78631626
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66489966
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42285194
17VDR_23849224_ChIP-Seq_CD4+_Human2.39628673
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35257475
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28024976
20XRN2_22483619_ChIP-Seq_HELA_Human2.25419323
21AR_21909140_ChIP-Seq_LNCAP_Human2.14525485
22FOXP3_21729870_ChIP-Seq_TREG_Human2.08935492
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08403516
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07381945
25DCP1A_22483619_ChIP-Seq_HELA_Human2.05512807
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04651931
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02624139
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96329100
29GABP_19822575_ChIP-Seq_HepG2_Human1.94015565
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88313873
31ELK1_19687146_ChIP-ChIP_HELA_Human1.87468060
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.83396795
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81970254
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81042589
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80596546
36TTF2_22483619_ChIP-Seq_HELA_Human1.78960276
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76159137
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73355028
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70899233
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69197353
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68593267
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67000904
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66604882
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66446194
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60558039
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57275684
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.57255789
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.55341542
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.55220529
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54820686
51CIITA_25753668_ChIP-Seq_RAJI_Human1.51353889
52EWS_26573619_Chip-Seq_HEK293_Human1.50186789
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49525004
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49075060
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48190628
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45956861
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45169714
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43517331
59KDM5A_27292631_Chip-Seq_BREAST_Human1.41177493
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.41140102
61ZNF274_21170338_ChIP-Seq_K562_Hela1.39666078
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38642887
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38183143
64MYC_22102868_ChIP-Seq_BL_Human1.37777939
65FUS_26573619_Chip-Seq_HEK293_Human1.34898383
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33644915
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33004647
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.24773715
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23297306
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23036131
71VDR_22108803_ChIP-Seq_LS180_Human1.21826827
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21793422
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21296705
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20993883
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20317673
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19158883
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.14865936
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11718906
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11525491
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10044549
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07339091
82MYC_18940864_ChIP-ChIP_HL60_Human1.05914049
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05755643
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05127446
85SPI1_23547873_ChIP-Seq_NB4_Human1.01721005
86TFEB_21752829_ChIP-Seq_HELA_Human1.00650949
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00346690
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98936890
89IGF1R_20145208_ChIP-Seq_DFB_Human0.97662525
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.97139262
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.96757375
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96461304
93TP63_19390658_ChIP-ChIP_HaCaT_Human0.96288696
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95192045
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95149187
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93611297
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89113108
98IRF1_19129219_ChIP-ChIP_H3396_Human0.88502911
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88334967
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88303457
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86965091
102SALL1_21062744_ChIP-ChIP_HESCs_Human0.85836028
103EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84781075
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82881752
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.82586291
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.82553671
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82493144
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80740021
109SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78890412
110ELF5_23300383_ChIP-Seq_T47D_Human0.78505483
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.78462685
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77229104
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76373936
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75588736
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74748588
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74430628
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.73317940
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69716038
119P300_19829295_ChIP-Seq_ESCs_Human0.65031790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.12297490
2MP0004957_abnormal_blastocyst_morpholog4.04893709
3MP0010094_abnormal_chromosome_stability3.89624689
4MP0003111_abnormal_nucleus_morphology3.54766861
5MP0003077_abnormal_cell_cycle3.52022441
6MP0008058_abnormal_DNA_repair3.12944624
7MP0002396_abnormal_hematopoietic_system3.01940271
8MP0008057_abnormal_DNA_replication2.94915660
9MP0003806_abnormal_nucleotide_metabolis2.70223832
10MP0003123_paternal_imprinting2.44609873
11MP0008007_abnormal_cellular_replicative2.43114388
12MP0003941_abnormal_skin_development2.07741102
13MP0008932_abnormal_embryonic_tissue2.07262662
14MP0001529_abnormal_vocalization2.06784419
15MP0001730_embryonic_growth_arrest2.00710888
16MP0010352_gastrointestinal_tract_polyps1.91245189
17MP0000490_abnormal_crypts_of1.84659842
18MP0000350_abnormal_cell_proliferation1.84068282
19MP0006072_abnormal_retinal_apoptosis1.79984926
20MP0009697_abnormal_copulation1.79196203
21MP0002938_white_spotting1.73932511
22MP0003786_premature_aging1.71365687
23MP0009333_abnormal_splenocyte_physiolog1.64594307
24MP0003763_abnormal_thymus_physiology1.63097447
25MP0010307_abnormal_tumor_latency1.59364973
26MP0009379_abnormal_foot_pigmentation1.58476254
27MP0002102_abnormal_ear_morphology1.58362615
28MP0005360_urolithiasis1.55324068
29MP0004808_abnormal_hematopoietic_stem1.55063257
30MP0001545_abnormal_hematopoietic_system1.51237560
31MP0005397_hematopoietic_system_phenotyp1.51237560
32MP0008877_abnormal_DNA_methylation1.50720939
33MP0003186_abnormal_redox_activity1.48933773
34MP0001697_abnormal_embryo_size1.47577269
35MP0001672_abnormal_embryogenesis/_devel1.45786606
36MP0005380_embryogenesis_phenotype1.45786606
37MP0002019_abnormal_tumor_incidence1.44574524
38MP0002132_abnormal_respiratory_system1.43901430
39MP0008789_abnormal_olfactory_epithelium1.43499366
40MP0003718_maternal_effect1.40185730
41MP0003984_embryonic_growth_retardation1.36477010
42MP0002080_prenatal_lethality1.35766563
43MP0005084_abnormal_gallbladder_morpholo1.33778526
44MP0000372_irregular_coat_pigmentation1.33737199
45MP0002088_abnormal_embryonic_growth/wei1.33592607
46MP0003937_abnormal_limbs/digits/tail_de1.32122927
47MP0003136_yellow_coat_color1.31438198
48MP0005085_abnormal_gallbladder_physiolo1.31419282
49MP0006036_abnormal_mitochondrial_physio1.29078040
50MP0002139_abnormal_hepatobiliary_system1.28877954
51MP0000313_abnormal_cell_death1.27045924
52MP0002234_abnormal_pharynx_morphology1.25157937
53MP0002086_abnormal_extraembryonic_tissu1.24736060
54MP0003567_abnormal_fetal_cardiomyocyte1.22105892
55MP0002398_abnormal_bone_marrow1.21890687
56MP0008995_early_reproductive_senescence1.20239315
57MP0004197_abnormal_fetal_growth/weight/1.19944978
58MP0000689_abnormal_spleen_morphology1.18913179
59MP0005365_abnormal_bile_salt1.17652446
60MP0006054_spinal_hemorrhage1.17383051
61MP0002722_abnormal_immune_system1.16170475
62MP0003011_delayed_dark_adaptation1.15111888
63MP0002638_abnormal_pupillary_reflex1.13328468
64MP0000703_abnormal_thymus_morphology1.13292773
65MP0001188_hyperpigmentation1.12779751
66MP0001764_abnormal_homeostasis1.12516859
67MP0001286_abnormal_eye_development1.11965724
68MP0003221_abnormal_cardiomyocyte_apopto1.08855253
69MP0006292_abnormal_olfactory_placode1.07887263
70MP0002084_abnormal_developmental_patter1.02696479
71MP0002085_abnormal_embryonic_tissue1.02232221
72MP0002736_abnormal_nociception_after1.01697562
73MP0003656_abnormal_erythrocyte_physiolo0.99570610
74MP0001835_abnormal_antigen_presentation0.98430216
75MP0002429_abnormal_blood_cell0.98188193
76MP0000049_abnormal_middle_ear0.94901980
77MP0000631_abnormal_neuroendocrine_gland0.94376030
78MP0004133_heterotaxia0.94072551
79MP0000647_abnormal_sebaceous_gland0.93890568
80MP0002697_abnormal_eye_size0.93574190
81MP0003315_abnormal_perineum_morphology0.92603208
82MP0005394_taste/olfaction_phenotype0.90648463
83MP0005499_abnormal_olfactory_system0.90648463
84MP0000358_abnormal_cell_content/0.90440831
85MP0005253_abnormal_eye_physiology0.90388094
86MP0000598_abnormal_liver_morphology0.90152586
87MP0010030_abnormal_orbit_morphology0.88577703
88MP0000716_abnormal_immune_system0.86758747
89MP0002210_abnormal_sex_determination0.86458276
90MP0001485_abnormal_pinna_reflex0.85681549
91MP0002111_abnormal_tail_morphology0.85355273
92MP0002837_dystrophic_cardiac_calcinosis0.84798727
93MP0001293_anophthalmia0.84414448
94MP0004215_abnormal_myocardial_fiber0.84202221
95MP0005220_abnormal_exocrine_pancreas0.82984139
96MP0001800_abnormal_humoral_immune0.82719836
97MP0002233_abnormal_nose_morphology0.82613721
98MP0001853_heart_inflammation0.81245083
99MP0002277_abnormal_respiratory_mucosa0.80890817
100MP0000858_altered_metastatic_potential0.79981804
101MP0003119_abnormal_digestive_system0.79825321
102MP0002751_abnormal_autonomic_nervous0.79506205
103MP0002166_altered_tumor_susceptibility0.77921436
104MP0006035_abnormal_mitochondrial_morpho0.77632887
105MP0005671_abnormal_response_to0.77345852
106MP0000465_gastrointestinal_hemorrhage0.77290973
107MP0001145_abnormal_male_reproductive0.76494061
108MP0005023_abnormal_wound_healing0.76455239
109MP0002095_abnormal_skin_pigmentation0.75618490
110MP0003890_abnormal_embryonic-extraembry0.75194506
111MP0003121_genomic_imprinting0.75063543
112MP0001119_abnormal_female_reproductive0.74839273
113MP0005395_other_phenotype0.74576879
114MP0005391_vision/eye_phenotype0.74323572
115MP0010155_abnormal_intestine_physiology0.73695004
116MP0003943_abnormal_hepatobiliary_system0.73110608
117MP0001727_abnormal_embryo_implantation0.72751609
118MP0002163_abnormal_gland_morphology0.70921076
119MP0001919_abnormal_reproductive_system0.70662690
120MP0002420_abnormal_adaptive_immunity0.70576907
121MP0000609_abnormal_liver_physiology0.69900271
122MP0003755_abnormal_palate_morphology0.69789082
123MP0005379_endocrine/exocrine_gland_phen0.69783449
124MP0001873_stomach_inflammation0.69697817
125MP0002160_abnormal_reproductive_system0.69477518
126MP0000477_abnormal_intestine_morphology0.69187913
127MP0005389_reproductive_system_phenotype0.69126940
128MP0009672_abnormal_birth_weight0.68342984
129MP0001819_abnormal_immune_cell0.68133382
130MP0000653_abnormal_sex_gland0.67499108
131MP0003787_abnormal_imprinting0.67307142
132MP0004147_increased_porphyrin_level0.67150904
133MP0001177_atelectasis0.66910740
134MP0002452_abnormal_antigen_presenting0.66530958
135MP0003436_decreased_susceptibility_to0.66319348
136MP0004142_abnormal_muscle_tone0.65274302
137MP0003698_abnormal_male_reproductive0.65032790
138MP0005367_renal/urinary_system_phenotyp0.64918999
139MP0000516_abnormal_urinary_system0.64918999
140MP0004264_abnormal_extraembryonic_tissu0.64834744
141MP0001929_abnormal_gametogenesis0.64671463
142MP0005075_abnormal_melanosome_morpholog0.64510599
143MP0005384_cellular_phenotype0.64492833
144MP0002723_abnormal_immune_serum0.64145780
145MP0005319_abnormal_enzyme/_coenzyme0.63252265
146MP0001915_intracranial_hemorrhage0.62622987
147MP0009785_altered_susceptibility_to0.62421824

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.80122839
2Birth length less than 3rd percentile (HP:0003561)4.67962006
3Acute encephalopathy (HP:0006846)4.37237230
4Abnormal mitochondria in muscle tissue (HP:0008316)4.33028442
5Reticulocytopenia (HP:0001896)4.22047050
6Progressive macrocephaly (HP:0004481)4.02263599
7Abnormality of cells of the erythroid lineage (HP:0012130)4.00943252
8Mitochondrial inheritance (HP:0001427)3.97321792
9Abnormal number of erythroid precursors (HP:0012131)3.78028492
10Colon cancer (HP:0003003)3.67418451
11Aplastic anemia (HP:0001915)3.51840662
12Cerebral edema (HP:0002181)3.44912711
13Oral leukoplakia (HP:0002745)3.42049126
14Thrombocytosis (HP:0001894)3.27310003
15Breast hypoplasia (HP:0003187)3.18797324
16Chromsome breakage (HP:0040012)3.00355201
17Macrocytic anemia (HP:0001972)2.90756973
18Pallor (HP:0000980)2.78838220
19Abnormality of the labia minora (HP:0012880)2.74285924
20Irregular epiphyses (HP:0010582)2.73072300
21Renal Fanconi syndrome (HP:0001994)2.71868240
22Microretrognathia (HP:0000308)2.70960800
23Abnormality of chromosome stability (HP:0003220)2.69406564
24Abnormality of the preputium (HP:0100587)2.68513321
25Lactic acidosis (HP:0003128)2.68443980
26Increased intramyocellular lipid droplets (HP:0012240)2.57512869
27Rough bone trabeculation (HP:0100670)2.53688946
28Abnormality of pyrimidine metabolism (HP:0004353)2.53001567
2911 pairs of ribs (HP:0000878)2.52694442
30Abnormality of alanine metabolism (HP:0010916)2.52168712
31Hyperalaninemia (HP:0003348)2.52168712
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52168712
33Patellar aplasia (HP:0006443)2.52007875
34Leukodystrophy (HP:0002415)2.50216376
35Multiple enchondromatosis (HP:0005701)2.48782660
36Exercise intolerance (HP:0003546)2.47944947
37Increased serum lactate (HP:0002151)2.47044954
38Hepatic necrosis (HP:0002605)2.45886134
39Carpal bone hypoplasia (HP:0001498)2.41502745
40Medulloblastoma (HP:0002885)2.41104943
41Abnormality of methionine metabolism (HP:0010901)2.40395321
42Abnormal lung lobation (HP:0002101)2.40245865
43Hypobetalipoproteinemia (HP:0003563)2.39917756
44Myelodysplasia (HP:0002863)2.39519231
45Methylmalonic acidemia (HP:0002912)2.36524585
46Hepatocellular necrosis (HP:0001404)2.34662299
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34125938
48Entropion (HP:0000621)2.33473570
49IgM deficiency (HP:0002850)2.32355566
50Aplasia/Hypoplasia of the patella (HP:0006498)2.32007228
51Respiratory failure (HP:0002878)2.31517148
52Microvesicular hepatic steatosis (HP:0001414)2.30558408
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30397854
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30397854
55Absent thumb (HP:0009777)2.28629600
56Rhabdomyosarcoma (HP:0002859)2.21357519
57Exertional dyspnea (HP:0002875)2.20314204
58Poikiloderma (HP:0001029)2.17765634
59Impulsivity (HP:0100710)2.16715776
60Abnormality of glycolysis (HP:0004366)2.16377271
61Increased serum pyruvate (HP:0003542)2.16377271
62Selective tooth agenesis (HP:0001592)2.14252267
63Abnormality of the anterior horn cell (HP:0006802)2.13904371
64Degeneration of anterior horn cells (HP:0002398)2.13904371
65Meckel diverticulum (HP:0002245)2.12668702
66Optic disc pallor (HP:0000543)2.10781874
67Lethargy (HP:0001254)2.10521500
68Pancytopenia (HP:0001876)2.08444396
69Premature graying of hair (HP:0002216)2.07529024
70Reduced antithrombin III activity (HP:0001976)2.07027974
71Type I transferrin isoform profile (HP:0003642)2.06343328
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04988697
73Agnosia (HP:0010524)2.04855778
74Increased muscle lipid content (HP:0009058)2.04418002
75Abnormality of serum amino acid levels (HP:0003112)2.03547194
76Abnormality of the ileum (HP:0001549)2.01357065
77Abnormality of the duodenum (HP:0002246)2.01279028
78Hyperglycinemia (HP:0002154)1.99698650
79Trismus (HP:0000211)1.99605980
80Cerebral hypomyelination (HP:0006808)1.99085800
81Cellular immunodeficiency (HP:0005374)1.98993947
82Abnormality of the pons (HP:0007361)1.98778221
83Methylmalonic aciduria (HP:0012120)1.98770707
84Stenosis of the external auditory canal (HP:0000402)1.98289983
85Hypoplasia of the pons (HP:0012110)1.96719111
86Megaloblastic anemia (HP:0001889)1.96448387
87Abnormal spermatogenesis (HP:0008669)1.96363554
88Lymphoma (HP:0002665)1.95795108
89Pancreatic cysts (HP:0001737)1.95347733
90Abnormality of midbrain morphology (HP:0002418)1.94836836
91Molar tooth sign on MRI (HP:0002419)1.94836836
92Bone marrow hypocellularity (HP:0005528)1.94750831
93Glossoptosis (HP:0000162)1.94068617
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90344002
95Amaurosis fugax (HP:0100576)1.89549124
96Progressive muscle weakness (HP:0003323)1.88792335
97Lipid accumulation in hepatocytes (HP:0006561)1.88709082
98Congenital, generalized hypertrichosis (HP:0004540)1.88279759
99Rhabdomyolysis (HP:0003201)1.87777072
100Neoplasm of the pancreas (HP:0002894)1.87620237
101Increased CSF lactate (HP:0002490)1.87362694
102Ependymoma (HP:0002888)1.87165899
103Pancreatic fibrosis (HP:0100732)1.86374086
104Septo-optic dysplasia (HP:0100842)1.86337613
105Squamous cell carcinoma (HP:0002860)1.85825680
106Increased hepatocellular lipid droplets (HP:0006565)1.85249352
107Abnormal trabecular bone morphology (HP:0100671)1.85095737
108Secondary amenorrhea (HP:0000869)1.82918842
109Neoplasm of the adrenal gland (HP:0100631)1.81634235
110Abnormality of the heme biosynthetic pathway (HP:0010472)1.81577504
111Aplasia/Hypoplasia of the uvula (HP:0010293)1.81395340
112Volvulus (HP:0002580)1.80517787
113Hyperglycinuria (HP:0003108)1.80508666
114Respiratory difficulties (HP:0002880)1.80498861
115Acute myeloid leukemia (HP:0004808)1.80374810
116Abnormality of placental membranes (HP:0011409)1.80073963
117Amniotic constriction ring (HP:0009775)1.80073963
118Glioma (HP:0009733)1.78908245
119Sloping forehead (HP:0000340)1.77614995
120Absent septum pellucidum (HP:0001331)1.77071438
121Neoplasm of the colon (HP:0100273)1.76743486
122Abnormality of the septum pellucidum (HP:0007375)1.76566776
123Horseshoe kidney (HP:0000085)1.75545369
124Sparse lateral eyebrow (HP:0005338)1.74196461
125Abnormality of reticulocytes (HP:0004312)1.73124408
126Sparse eyelashes (HP:0000653)1.72215256
127Basal cell carcinoma (HP:0002671)1.70904194
128Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69322419
129Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69304264
130Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69124122
131Abnormal biliary tract morphology (HP:0012440)1.67689415
132Nausea (HP:0002018)1.66541839
133Duodenal stenosis (HP:0100867)1.66330212
134Small intestinal stenosis (HP:0012848)1.66330212
135CNS demyelination (HP:0007305)1.65566860
1363-Methylglutaconic aciduria (HP:0003535)1.63015753
137Abnormal protein glycosylation (HP:0012346)1.62513413
138Abnormal glycosylation (HP:0012345)1.62513413
139Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62513413
140Abnormal protein N-linked glycosylation (HP:0012347)1.62513413
141Ragged-red muscle fibers (HP:0003200)1.62238903
142Triphalangeal thumb (HP:0001199)1.61257582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.27966374
2WEE13.86021323
3BUB13.56349311
4VRK23.34945339
5CDC73.18463149
6STK162.68361664
7BRSK22.59916564
8NME22.53657787
9TRIM282.50442169
10ACVR1B2.50009409
11SRPK12.45512526
12EIF2AK32.28009117
13NEK22.27668815
14TSSK62.23664492
15RPS6KA42.19719609
16VRK12.17145097
17TNIK1.94288532
18TAF11.82449820
19FLT31.71407351
20WNK31.69720451
21PLK11.69046844
22PLK41.61785034
23TLK11.61516720
24TTK1.60778568
25AURKB1.58135008
26MKNK11.57935703
27MAP4K21.51615647
28BMPR1B1.46435244
29NEK11.45046478
30MAP4K11.43757730
31RPS6KB21.42197998
32ATR1.40446926
33PASK1.37217502
34PLK31.34388741
35DYRK31.32871637
36CDK71.32332287
37MAP3K31.22420895
38ZAK1.22321815
39MKNK21.20956244
40PNCK1.18614832
41CDK41.17282928
42TGFBR11.15999936
43BCR1.14894003
44EPHA21.10639226
45BCKDK1.10324857
46MAP3K121.10232188
47CHEK21.07153714
48SCYL21.06881416
49STK101.06625026
50MAP3K81.06424529
51BRD41.04005507
52TXK1.03472979
53BRSK11.02283791
54TEC1.02169355
55CCNB11.01072285
56PIM21.00873240
57CDK81.00580163
58NEK90.97748693
59KDR0.97529701
60PIM10.95824494
61MAP3K110.95705394
62CHEK10.94904300
63PKN20.93987456
64MAP2K30.92858136
65STK40.91614085
66CSNK1G20.91098661
67DYRK20.87542935
68AURKA0.87175684
69ERBB30.86425844
70EIF2AK20.85788819
71STK38L0.85556641
72TAOK20.83321982
73TESK20.83301428
74MAP3K40.82510152
75CSNK1A1L0.81966963
76CDK120.81502087
77MST40.78773995
78PDK40.78021946
79PDK30.78021946
80JAK30.74138867
81PBK0.73069611
82ATM0.72936198
83ZAP700.70834507
84CSNK2A20.70484161
85CDK190.68631519
86MAP2K70.68187348
87LRRK20.67171599
88CSNK2A10.62399359
89RPS6KA50.61554911
90PLK20.60527904
91CDK20.59698886
92BTK0.57857871
93STK30.57783695
94INSRR0.57377739
95PDK20.55574726
96PAK40.54196002
97NME10.51950851
98KIT0.51625965
99PRKG20.50943871
100ALK0.50114121
101OXSR10.49768187
102ERBB40.49668506
103CSNK1E0.49235521
104FRK0.48948233
105TYK20.47801875
106CDK60.47472173
107MAPK110.47074260
108TAOK30.46382937
109CDK30.44972723
110GRK10.44178407
111CSF1R0.43149703
112DAPK10.42046476
113IKBKB0.40624424
114STK240.39961618
115NUAK10.39807110
116CDK10.39697466
117MAP2K60.38420336
118CSNK1G30.36152171
119PRKCG0.35979619
120MAP3K50.35895782
121FGFR10.32321729
122CLK10.31252863
123EEF2K0.31227046
124STK390.30466556
125MAPKAPK50.30399712
126MINK10.28477139
127TBK10.28061416
128PRKDC0.27664513
129IKBKE0.27402287
130LYN0.27072779
131CSNK1G10.26958862
132PRKCI0.25842077
133ABL20.25756159
134CSNK1A10.25296093
135BRAF0.22557059
136CDK90.21975706
137CASK0.20578905
138CDK140.18868684
139CDK180.18235395

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.00640385
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.70075903
3Ribosome_Homo sapiens_hsa030103.68948054
4Mismatch repair_Homo sapiens_hsa034303.55783714
5Oxidative phosphorylation_Homo sapiens_hsa001903.19675624
6RNA polymerase_Homo sapiens_hsa030203.14562202
7Proteasome_Homo sapiens_hsa030502.93135909
8Spliceosome_Homo sapiens_hsa030402.85557471
9RNA transport_Homo sapiens_hsa030132.72444208
10Homologous recombination_Homo sapiens_hsa034402.68321545
11One carbon pool by folate_Homo sapiens_hsa006702.54762002
12Pyrimidine metabolism_Homo sapiens_hsa002402.44412552
13Nucleotide excision repair_Homo sapiens_hsa034202.39805336
14Base excision repair_Homo sapiens_hsa034102.36904201
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34781457
16Cell cycle_Homo sapiens_hsa041102.11118966
17Non-homologous end-joining_Homo sapiens_hsa034502.07453477
18Fanconi anemia pathway_Homo sapiens_hsa034601.80420249
19Basal transcription factors_Homo sapiens_hsa030221.76206585
20Alzheimers disease_Homo sapiens_hsa050101.75827122
21RNA degradation_Homo sapiens_hsa030181.69956373
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66899723
23Folate biosynthesis_Homo sapiens_hsa007901.46696265
24Selenocompound metabolism_Homo sapiens_hsa004501.44536226
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38377640
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.38173614
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32771974
28p53 signaling pathway_Homo sapiens_hsa041151.30680547
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.29520114
30Pentose phosphate pathway_Homo sapiens_hsa000301.29274726
31Purine metabolism_Homo sapiens_hsa002301.26830907
32Systemic lupus erythematosus_Homo sapiens_hsa053221.25942359
33Steroid biosynthesis_Homo sapiens_hsa001001.24938484
34Sulfur relay system_Homo sapiens_hsa041221.17919050
35mRNA surveillance pathway_Homo sapiens_hsa030151.17541355
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17184617
37Fatty acid elongation_Homo sapiens_hsa000621.16267508
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15803653
39Protein export_Homo sapiens_hsa030601.13704001
40Biosynthesis of amino acids_Homo sapiens_hsa012301.13682952
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10696027
42Vitamin B6 metabolism_Homo sapiens_hsa007501.08470213
43Cardiac muscle contraction_Homo sapiens_hsa042601.06275937
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05311491
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00614206
46Epstein-Barr virus infection_Homo sapiens_hsa051690.98554316
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98117338
48Antigen processing and presentation_Homo sapiens_hsa046120.96476918
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95847904
50Carbon metabolism_Homo sapiens_hsa012000.95793702
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94316331
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94020828
53Herpes simplex infection_Homo sapiens_hsa051680.92934493
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.77341850
55Viral carcinogenesis_Homo sapiens_hsa052030.75354178
56Legionellosis_Homo sapiens_hsa051340.72461951
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70004830
58Glutathione metabolism_Homo sapiens_hsa004800.69777568
59Primary immunodeficiency_Homo sapiens_hsa053400.66170684
60Sulfur metabolism_Homo sapiens_hsa009200.63597179
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61616286
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61107519
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60307277
64Butanoate metabolism_Homo sapiens_hsa006500.56332658
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55279637
66Thyroid cancer_Homo sapiens_hsa052160.54230607
67Pyruvate metabolism_Homo sapiens_hsa006200.51127704
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.50434141
69N-Glycan biosynthesis_Homo sapiens_hsa005100.49987177
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46986739
71Measles_Homo sapiens_hsa051620.46829268
72Collecting duct acid secretion_Homo sapiens_hsa049660.45280909
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43779590
74Fatty acid metabolism_Homo sapiens_hsa012120.43568057
75Metabolic pathways_Homo sapiens_hsa011000.43183499
76HTLV-I infection_Homo sapiens_hsa051660.41789900
77Propanoate metabolism_Homo sapiens_hsa006400.40974377
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40573381
79Phototransduction_Homo sapiens_hsa047440.40300774
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39694445
81Fatty acid degradation_Homo sapiens_hsa000710.39597070
82Peroxisome_Homo sapiens_hsa041460.38860159
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38127865
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.37116260
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.37037775
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.35761515
87Huntingtons disease_Homo sapiens_hsa050160.34358882
88Arginine and proline metabolism_Homo sapiens_hsa003300.32497987
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32388207
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32179726
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31840617
92Oocyte meiosis_Homo sapiens_hsa041140.31714438
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31013570
94Hematopoietic cell lineage_Homo sapiens_hsa046400.30881509
95Arginine biosynthesis_Homo sapiens_hsa002200.30290725
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29646276
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28243967
98Influenza A_Homo sapiens_hsa051640.27091132
99Small cell lung cancer_Homo sapiens_hsa052220.26863387
100Parkinsons disease_Homo sapiens_hsa050120.26444680
101Regulation of autophagy_Homo sapiens_hsa041400.26342562
102Hepatitis B_Homo sapiens_hsa051610.25640865
103TGF-beta signaling pathway_Homo sapiens_hsa043500.25371964
104Galactose metabolism_Homo sapiens_hsa000520.25338077
105Caffeine metabolism_Homo sapiens_hsa002320.24923141
106Tryptophan metabolism_Homo sapiens_hsa003800.24211806
107Apoptosis_Homo sapiens_hsa042100.23779994
108Chemical carcinogenesis_Homo sapiens_hsa052040.22854217
109Retinol metabolism_Homo sapiens_hsa008300.22841274
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22751008
111MicroRNAs in cancer_Homo sapiens_hsa052060.22553161
112Fructose and mannose metabolism_Homo sapiens_hsa000510.22352108
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.22019839
114Basal cell carcinoma_Homo sapiens_hsa052170.21977020
115Renin-angiotensin system_Homo sapiens_hsa046140.21735620
116beta-Alanine metabolism_Homo sapiens_hsa004100.20699102
117Lysine degradation_Homo sapiens_hsa003100.20263750
118Vitamin digestion and absorption_Homo sapiens_hsa049770.17420305
119Other glycan degradation_Homo sapiens_hsa005110.17291639
120Shigellosis_Homo sapiens_hsa051310.16913740
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16606612
122Nitrogen metabolism_Homo sapiens_hsa009100.16254654
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14430095
124Hedgehog signaling pathway_Homo sapiens_hsa043400.10259887
125Wnt signaling pathway_Homo sapiens_hsa043100.09955638
126Hippo signaling pathway_Homo sapiens_hsa043900.09866122
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.07944956
128Tyrosine metabolism_Homo sapiens_hsa003500.07262823
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05363396

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