TRMT11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.90249059
2DNA replication initiation (GO:0006270)4.63296343
3DNA strand elongation involved in DNA replication (GO:0006271)4.63204423
4telomere maintenance via semi-conservative replication (GO:0032201)4.54343244
5CENP-A containing nucleosome assembly (GO:0034080)4.49934959
6DNA strand elongation (GO:0022616)4.48992545
7maturation of SSU-rRNA (GO:0030490)4.43661631
8chromatin remodeling at centromere (GO:0031055)4.37654140
9DNA replication checkpoint (GO:0000076)4.36019505
10DNA deamination (GO:0045006)4.34993980
11proteasome assembly (GO:0043248)4.34285976
12purine nucleobase biosynthetic process (GO:0009113)4.32258500
13nucleobase biosynthetic process (GO:0046112)4.23931544
14telomere maintenance via recombination (GO:0000722)4.13359821
15DNA double-strand break processing (GO:0000729)3.97540676
16mitotic metaphase plate congression (GO:0007080)3.92366555
17mitotic recombination (GO:0006312)3.87372921
18ribosome biogenesis (GO:0042254)3.85680318
19DNA replication-independent nucleosome organization (GO:0034724)3.84842463
20DNA replication-independent nucleosome assembly (GO:0006336)3.84842463
21ribosomal small subunit biogenesis (GO:0042274)3.81529594
22formation of translation preinitiation complex (GO:0001731)3.80516100
23DNA unwinding involved in DNA replication (GO:0006268)3.79537688
24telomere maintenance via telomere lengthening (GO:0010833)3.78958410
25ribonucleoprotein complex biogenesis (GO:0022613)3.78423435
26regulation of mitotic spindle checkpoint (GO:1903504)3.78401517
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.78401517
28pseudouridine synthesis (GO:0001522)3.75418440
29rRNA modification (GO:0000154)3.65211227
30ribosomal large subunit biogenesis (GO:0042273)3.63341944
31IMP biosynthetic process (GO:0006188)3.57940974
32kinetochore organization (GO:0051383)3.57667929
33maturation of 5.8S rRNA (GO:0000460)3.57580120
34histone exchange (GO:0043486)3.56075198
357-methylguanosine mRNA capping (GO:0006370)3.56070735
36rRNA processing (GO:0006364)3.55230529
37establishment of integrated proviral latency (GO:0075713)3.55114512
387-methylguanosine RNA capping (GO:0009452)3.54088633
39RNA capping (GO:0036260)3.54088633
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.50434680
41protein deneddylation (GO:0000338)3.48534306
42transcription-coupled nucleotide-excision repair (GO:0006283)3.48247106
43viral mRNA export from host cell nucleus (GO:0046784)3.48238450
44regulation of centriole replication (GO:0046599)3.48005396
45cullin deneddylation (GO:0010388)3.46584962
46attachment of spindle microtubules to kinetochore (GO:0008608)3.44237281
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44050730
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.43588438
49metaphase plate congression (GO:0051310)3.43390991
50rRNA metabolic process (GO:0016072)3.43089699
51viral transcription (GO:0019083)3.40898460
52translational termination (GO:0006415)3.37920882
53transcription elongation from RNA polymerase I promoter (GO:0006362)3.36044363
54ribosome assembly (GO:0042255)3.35691203
55kinetochore assembly (GO:0051382)3.35420589
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34610706
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.34312061
58termination of RNA polymerase III transcription (GO:0006386)3.34312061
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33719894
60spliceosomal snRNP assembly (GO:0000387)3.32721641
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.31616963
62respiratory chain complex IV assembly (GO:0008535)3.30431850
63somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.29474817
64somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.29474817
65isotype switching (GO:0045190)3.29474817
66replication fork processing (GO:0031297)3.28609476
67termination of RNA polymerase I transcription (GO:0006363)3.27602824
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27356870
69mitotic nuclear envelope disassembly (GO:0007077)3.25866228
70IMP metabolic process (GO:0046040)3.25859126
71negative regulation of DNA-dependent DNA replication (GO:2000104)3.24834404
72cellular component biogenesis (GO:0044085)3.21695412
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21441120
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20242428
75DNA replication-dependent nucleosome organization (GO:0034723)3.19173407
76DNA replication-dependent nucleosome assembly (GO:0006335)3.19173407
77protein K6-linked ubiquitination (GO:0085020)3.16894963
78deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16872677
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15039341
80cell cycle G1/S phase transition (GO:0044843)3.14284727
81G1/S transition of mitotic cell cycle (GO:0000082)3.14284727
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.13028565
83spliceosomal complex assembly (GO:0000245)3.12363037
84rRNA methylation (GO:0031167)3.11102364
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09799846
86cotranslational protein targeting to membrane (GO:0006613)3.09700284
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07776885
88negative regulation of ligase activity (GO:0051352)3.07776885
89translational initiation (GO:0006413)3.07446956
90somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07076813
91somatic hypermutation of immunoglobulin genes (GO:0016446)3.07076813
92L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.06025733
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05791192
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05791192
95translational elongation (GO:0006414)3.05196499
96signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04576136
97signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04576136
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04576136
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04371946
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04371946
101protein targeting to ER (GO:0045047)3.04092745
102double-strand break repair via nonhomologous end joining (GO:0006303)3.04033325
103non-recombinational repair (GO:0000726)3.04033325
104protein complex biogenesis (GO:0070271)3.03653569
105deoxyribonucleotide biosynthetic process (GO:0009263)3.03446895
106folic acid-containing compound biosynthetic process (GO:0009396)3.03277971
107transcription from RNA polymerase I promoter (GO:0006360)3.02420551
108establishment of chromosome localization (GO:0051303)3.01289810
109mitochondrial respiratory chain complex assembly (GO:0033108)3.00557725
110meiotic chromosome segregation (GO:0045132)3.00046086
111protein localization to kinetochore (GO:0034501)2.99689012
112translation (GO:0006412)2.99352067
113nuclear envelope disassembly (GO:0051081)2.98944380
114membrane disassembly (GO:0030397)2.98944380
115signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97715527
116signal transduction involved in DNA damage checkpoint (GO:0072422)2.97715527
117cytochrome complex assembly (GO:0017004)2.92279275
118DNA ligation (GO:0006266)2.91608583
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90501935
120mitochondrial respiratory chain complex I assembly (GO:0032981)2.90501935
121NADH dehydrogenase complex assembly (GO:0010257)2.90501935
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88401544
123DNA damage response, detection of DNA damage (GO:0042769)2.88377475
124spindle checkpoint (GO:0031577)2.87918806
125resolution of meiotic recombination intermediates (GO:0000712)2.87525084
126water-soluble vitamin biosynthetic process (GO:0042364)2.85957290
127mitotic spindle checkpoint (GO:0071174)2.83927626
128mitochondrial RNA metabolic process (GO:0000959)2.83920909
129centriole replication (GO:0007099)2.83363720
130recombinational repair (GO:0000725)2.82763054
131double-strand break repair via homologous recombination (GO:0000724)2.82138705
132mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81957725
133histone mRNA metabolic process (GO:0008334)2.79579985
134DNA catabolic process, exonucleolytic (GO:0000738)2.79488682
135amino acid activation (GO:0043038)2.77977471
136tRNA aminoacylation (GO:0043039)2.77977471
137negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.77823017
138negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77823017
139negative regulation of mitotic sister chromatid separation (GO:2000816)2.77823017
140negative regulation of sister chromatid segregation (GO:0033046)2.77823017
141negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77823017
142regulation of mitochondrial translation (GO:0070129)2.76755626
143synapsis (GO:0007129)2.75123468
144negative regulation of chromosome segregation (GO:0051985)2.74142561
145tRNA aminoacylation for protein translation (GO:0006418)2.74023464
146postreplication repair (GO:0006301)2.72972269
147regulation of mitotic metaphase/anaphase transition (GO:0030071)2.72931861
148regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.72931861
149regulation of centrosome cycle (GO:0046605)2.71711260
150intra-S DNA damage checkpoint (GO:0031573)2.71169333
151regulation of DNA endoreduplication (GO:0032875)2.70429084
152organelle disassembly (GO:1903008)2.67245219
153negative regulation of DNA recombination (GO:0045910)2.66937842
154chaperone-mediated protein transport (GO:0072321)2.65768955
155histone H2A acetylation (GO:0043968)2.64790883
156ATP synthesis coupled proton transport (GO:0015986)2.64227214
157energy coupled proton transport, down electrochemical gradient (GO:0015985)2.64227214
158nuclear pore organization (GO:0006999)2.63370962
159regulation of mitotic sister chromatid separation (GO:0010965)2.63041706
160regulation of mitotic sister chromatid segregation (GO:0033047)2.63041706
161regulation of sister chromatid segregation (GO:0033045)2.63041706
162mitotic sister chromatid segregation (GO:0000070)2.62443412
163mitotic spindle assembly checkpoint (GO:0007094)2.61525226

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.97006609
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.50342204
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26877704
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.82145447
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.73355216
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62367647
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52077182
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45341612
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.06888435
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95061418
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93303242
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.90054951
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88936088
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82478618
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80353458
16* VDR_23849224_ChIP-Seq_CD4+_Human2.67778649
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65980629
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63896887
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63693699
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54632006
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.49612221
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48128701
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42712751
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27862191
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25546400
26XRN2_22483619_ChIP-Seq_HELA_Human2.25269489
27ZNF274_21170338_ChIP-Seq_K562_Hela2.24683187
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22584050
29ELK1_19687146_ChIP-ChIP_HELA_Human2.22428238
30FOXP3_21729870_ChIP-Seq_TREG_Human2.22220092
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22049484
32* DCP1A_22483619_ChIP-Seq_HELA_Human2.20288699
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.16753963
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12345568
35SRF_21415370_ChIP-Seq_HL-1_Mouse2.11266109
36IGF1R_20145208_ChIP-Seq_DFB_Human2.10689694
37POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08191250
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06037808
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03634311
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01937732
41YY1_21170310_ChIP-Seq_MESCs_Mouse2.00337446
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97037676
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96702357
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94051626
45VDR_22108803_ChIP-Seq_LS180_Human1.93993412
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93413297
47* GABP_19822575_ChIP-Seq_HepG2_Human1.93265789
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93042141
49AR_21909140_ChIP-Seq_LNCAP_Human1.91616360
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91517556
51TTF2_22483619_ChIP-Seq_HELA_Human1.91065214
52TAF15_26573619_Chip-Seq_HEK293_Human1.90481885
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87036427
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.79959968
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67070020
56* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66252133
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64482670
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.62146939
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58742206
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57741324
61GBX2_23144817_ChIP-Seq_PC3_Human1.56404328
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.55683139
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55399926
64P300_19829295_ChIP-Seq_ESCs_Human1.55174337
65MYC_18940864_ChIP-ChIP_HL60_Human1.51893576
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51799183
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50718985
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47291058
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44825456
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43718349
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40834146
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40181084
73CIITA_25753668_ChIP-Seq_RAJI_Human1.40025952
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39208465
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36668441
76KDM5A_27292631_Chip-Seq_BREAST_Human1.28506889
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26564766
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22725210
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19575783
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.19117886
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17981128
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16832548
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15826381
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.12584050
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10784261
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.09237282
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09207341
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09118177
89ER_23166858_ChIP-Seq_MCF-7_Human1.07791871
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.05430952
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04965801
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04416579
93IRF1_19129219_ChIP-ChIP_H3396_Human1.02993074
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02858618
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02772845
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02697649
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01613996
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01539032
99* EZH2_27294783_Chip-Seq_NPCs_Mouse1.01296182
100* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00996606
101TFEB_21752829_ChIP-Seq_HELA_Human1.00698860
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99796404
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98058446
104CBP_20019798_ChIP-Seq_JUKART_Human0.98058446
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95473387
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94298135
107SPI1_23547873_ChIP-Seq_NB4_Human0.94056859
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93533031
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93091077
110KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92920358
111TP53_22573176_ChIP-Seq_HFKS_Human0.92540519
112NFE2_27457419_Chip-Seq_LIVER_Mouse0.92007520
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91948177
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91708687
115SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91345406
116NANOG_19829295_ChIP-Seq_ESCs_Human0.90905128
117SOX2_19829295_ChIP-Seq_ESCs_Human0.90905128
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90850119
119SALL1_21062744_ChIP-ChIP_HESCs_Human0.89710139
120TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87972510
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87848904
122HTT_18923047_ChIP-ChIP_STHdh_Human0.85797941
123SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85732702
124IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85149910
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83776002
126EWS_26573619_Chip-Seq_HEK293_Human0.82453188
127GATA1_22025678_ChIP-Seq_K562_Human0.81652251
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80823672
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80590342
130SOX17_20123909_ChIP-Seq_XEN_Mouse0.80439408
131* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78090685
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76454472
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68448919
134SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66448420
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.64695966
136FUS_26573619_Chip-Seq_HEK293_Human0.62591903
137DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.61380169
138POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.60814825
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.60389973
140STAT4_19710469_ChIP-ChIP_TH1__Mouse0.60278569
141TBX5_21415370_ChIP-Seq_HL-1_Mouse0.58806053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.44328134
2MP0008057_abnormal_DNA_replication5.41418152
3MP0010094_abnormal_chromosome_stability4.95851586
4MP0004957_abnormal_blastocyst_morpholog4.43629624
5MP0003111_abnormal_nucleus_morphology4.14162760
6MP0008058_abnormal_DNA_repair4.13560674
7MP0003077_abnormal_cell_cycle3.90207239
8MP0008007_abnormal_cellular_replicative3.00419833
9MP0002396_abnormal_hematopoietic_system2.95448294
10MP0008877_abnormal_DNA_methylation2.81712494
11MP0003123_paternal_imprinting2.64255050
12MP0008932_abnormal_embryonic_tissue2.62823484
13MP0003718_maternal_effect2.18535436
14MP0003786_premature_aging2.16433170
15MP0003806_abnormal_nucleotide_metabolis2.08038495
16MP0006072_abnormal_retinal_apoptosis2.02801749
17MP0004147_increased_porphyrin_level1.98169375
18MP0009697_abnormal_copulation1.94299187
19MP0003880_abnormal_central_pattern1.88928317
20MP0003195_calcinosis1.86539962
21MP0001730_embryonic_growth_arrest1.78087728
22MP0009379_abnormal_foot_pigmentation1.77715870
23MP0000350_abnormal_cell_proliferation1.74635627
24MP0000490_abnormal_crypts_of1.73528232
25MP0003763_abnormal_thymus_physiology1.71021714
26MP0009333_abnormal_splenocyte_physiolog1.71004851
27MP0006292_abnormal_olfactory_placode1.65363933
28MP0000569_abnormal_digit_pigmentation1.54252846
29MP0003121_genomic_imprinting1.51187331
30MP0003937_abnormal_limbs/digits/tail_de1.50641156
31MP0002132_abnormal_respiratory_system1.49238495
32MP0002210_abnormal_sex_determination1.47821255
33MP0005551_abnormal_eye_electrophysiolog1.47060428
34MP0003186_abnormal_redox_activity1.46954321
35MP0001529_abnormal_vocalization1.43501738
36MP0008789_abnormal_olfactory_epithelium1.41533814
37MP0005253_abnormal_eye_physiology1.40683918
38MP0002019_abnormal_tumor_incidence1.38918342
39MP0005671_abnormal_response_to1.38436363
40MP0001986_abnormal_taste_sensitivity1.32171446
41MP0000313_abnormal_cell_death1.31906093
42MP0002837_dystrophic_cardiac_calcinosis1.30664518
43MP0002398_abnormal_bone_marrow1.29338487
44MP0006054_spinal_hemorrhage1.27692345
45MP0001145_abnormal_male_reproductive1.26616655
46MP0002234_abnormal_pharynx_morphology1.26265851
47MP0001853_heart_inflammation1.25792077
48MP0000647_abnormal_sebaceous_gland1.24810335
49MP0001697_abnormal_embryo_size1.24155694
50MP0010352_gastrointestinal_tract_polyps1.24121727
51MP0001984_abnormal_olfaction1.23608722
52MP0005394_taste/olfaction_phenotype1.22266605
53MP0005499_abnormal_olfactory_system1.22266605
54MP0002751_abnormal_autonomic_nervous1.21384394
55MP0000653_abnormal_sex_gland1.20966431
56MP0001929_abnormal_gametogenesis1.19896413
57MP0004215_abnormal_myocardial_fiber1.17788507
58MP0000689_abnormal_spleen_morphology1.16947190
59MP0002080_prenatal_lethality1.15773836
60MP0002233_abnormal_nose_morphology1.13594458
61MP0005075_abnormal_melanosome_morpholog1.12582840
62MP0006036_abnormal_mitochondrial_physio1.12035525
63MP0002722_abnormal_immune_system1.11250575
64MP0000566_synostosis1.11140088
65MP0000703_abnormal_thymus_morphology1.09848139
66MP0004808_abnormal_hematopoietic_stem1.08572053
67MP0001119_abnormal_female_reproductive1.08336067
68MP0001764_abnormal_homeostasis1.07043944
69MP0010307_abnormal_tumor_latency1.05935863
70MP0002163_abnormal_gland_morphology1.05839539
71MP0000631_abnormal_neuroendocrine_gland1.05485888
72MP0009046_muscle_twitch1.04833917
73MP0001286_abnormal_eye_development1.03974320
74MP0003656_abnormal_erythrocyte_physiolo1.02969051
75MP0004142_abnormal_muscle_tone1.02687655
76MP0002429_abnormal_blood_cell1.02481752
77MP0001485_abnormal_pinna_reflex1.02347544
78MP0001672_abnormal_embryogenesis/_devel1.01920267
79MP0005380_embryogenesis_phenotype1.01920267
80MP0003941_abnormal_skin_development0.99745863
81MP0005645_abnormal_hypothalamus_physiol0.98429115
82MP0002102_abnormal_ear_morphology0.97495816
83MP0003122_maternal_imprinting0.97459689
84MP0001545_abnormal_hematopoietic_system0.96959570
85MP0005397_hematopoietic_system_phenotyp0.96959570
86MP0005391_vision/eye_phenotype0.96424841
87MP0003119_abnormal_digestive_system0.96183736
88MP0000383_abnormal_hair_follicle0.94658913
89MP0003315_abnormal_perineum_morphology0.94467867
90MP0002090_abnormal_vision0.93694631
91MP0002697_abnormal_eye_size0.90928798
92MP0003984_embryonic_growth_retardation0.90833281
93MP0002160_abnormal_reproductive_system0.90569502
94MP0000716_abnormal_immune_system0.90489489
95MP0004145_abnormal_muscle_electrophysio0.90027153
96MP0005389_reproductive_system_phenotype0.89688279
97MP0002085_abnormal_embryonic_tissue0.88331232
98MP0005266_abnormal_metabolism0.87474826
99MP0001486_abnormal_startle_reflex0.86757920
100MP0002638_abnormal_pupillary_reflex0.86679490
101MP0002088_abnormal_embryonic_growth/wei0.86441787
102MP0001324_abnormal_eye_pigmentation0.86049280
103MP0005646_abnormal_pituitary_gland0.85544704
104MP0000427_abnormal_hair_cycle0.85485983
105MP0003724_increased_susceptibility_to0.85321986
106MP0003698_abnormal_male_reproductive0.84675246
107MP0005187_abnormal_penis_morphology0.84524345
108MP0001188_hyperpigmentation0.83647176
109MP0000049_abnormal_middle_ear0.83211953
110MP0008260_abnormal_autophagy0.82807872
111MP0006276_abnormal_autonomic_nervous0.82578943
112MP0002938_white_spotting0.82564787
113MP0003011_delayed_dark_adaptation0.82190682
114MP0001293_anophthalmia0.81440064
115MP0000778_abnormal_nervous_system0.81064298
116MP0003755_abnormal_palate_morphology0.81000649
117MP0002420_abnormal_adaptive_immunity0.78672761
118MP0001905_abnormal_dopamine_level0.78411714
119MP0006035_abnormal_mitochondrial_morpho0.78369991
120MP0003567_abnormal_fetal_cardiomyocyte0.77965705
121MP0002086_abnormal_extraembryonic_tissu0.77273809
122MP0010678_abnormal_skin_adnexa0.75795486
123MP0001346_abnormal_lacrimal_gland0.75138650
124MP0005379_endocrine/exocrine_gland_phen0.74988935
125MP0001819_abnormal_immune_cell0.74613906
126MP0002736_abnormal_nociception_after0.74422860
127MP0002272_abnormal_nervous_system0.74064141
128MP0002095_abnormal_skin_pigmentation0.73944724
129MP0005174_abnormal_tail_pigmentation0.73731801
130MP0005408_hypopigmentation0.73496777
131MP0000465_gastrointestinal_hemorrhage0.71573002
132MP0000858_altered_metastatic_potential0.71315221
133MP0000358_abnormal_cell_content/0.69667832
134MP0005384_cellular_phenotype0.65137593
135MP0002723_abnormal_immune_serum0.63796065
136MP0001919_abnormal_reproductive_system0.63744278
137MP0001800_abnormal_humoral_immune0.63223680
138MP0002084_abnormal_developmental_patter0.63126615
139MP0003136_yellow_coat_color0.63071810
140MP0003787_abnormal_imprinting0.62690824
141MP0009785_altered_susceptibility_to0.62063761
142MP0003943_abnormal_hepatobiliary_system0.61085392
143MP0001835_abnormal_antigen_presentation0.60131439
144MP0000372_irregular_coat_pigmentation0.58822416
145MP0003890_abnormal_embryonic-extraembry0.57970576
146MP0002452_abnormal_antigen_presenting0.57630447
147MP0004197_abnormal_fetal_growth/weight/0.57329366
148MP0001915_intracranial_hemorrhage0.56292225
149MP0004133_heterotaxia0.53622408

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.70845747
2Aplastic anemia (HP:0001915)4.55881251
3Abnormal number of erythroid precursors (HP:0012131)4.44397576
4Abnormality of cells of the erythroid lineage (HP:0012130)4.37168955
5Breast hypoplasia (HP:0003187)3.98747215
6Reticulocytopenia (HP:0001896)3.71505678
7Oral leukoplakia (HP:0002745)3.67274362
8Abnormality of the heme biosynthetic pathway (HP:0010472)3.44274343
9Chromsome breakage (HP:0040012)3.40800809
10Cerebral hypomyelination (HP:0006808)3.14201983
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06165003
12Abnormality of the preputium (HP:0100587)3.03196897
13Abnormality of chromosome stability (HP:0003220)2.97662594
14Abnormality of glycolysis (HP:0004366)2.96027144
15Increased serum pyruvate (HP:0003542)2.96027144
16Rough bone trabeculation (HP:0100670)2.92168585
17Increased hepatocellular lipid droplets (HP:0006565)2.90693138
18Colon cancer (HP:0003003)2.87077009
19Meckel diverticulum (HP:0002245)2.85348885
20Abnormality of alanine metabolism (HP:0010916)2.84845738
21Hyperalaninemia (HP:0003348)2.84845738
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.84845738
23Macrocytic anemia (HP:0001972)2.84062524
24Type I transferrin isoform profile (HP:0003642)2.79201118
25Hepatocellular necrosis (HP:0001404)2.75361471
26Patellar aplasia (HP:0006443)2.73701113
2711 pairs of ribs (HP:0000878)2.73543073
28Increased serum lactate (HP:0002151)2.73147318
29Abnormal lung lobation (HP:0002101)2.71965894
30Abnormality of the ileum (HP:0001549)2.71554233
31Supernumerary spleens (HP:0009799)2.69429477
32Mitochondrial inheritance (HP:0001427)2.69270856
33Increased CSF lactate (HP:0002490)2.68035240
34Medial flaring of the eyebrow (HP:0010747)2.67084981
35True hermaphroditism (HP:0010459)2.65957968
36Premature graying of hair (HP:0002216)2.65140574
37Myelodysplasia (HP:0002863)2.64496614
38Cerebral edema (HP:0002181)2.64072940
39Pancytopenia (HP:0001876)2.63832449
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61451243
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61451243
42Hyperglycinemia (HP:0002154)2.58797052
43Pallor (HP:0000980)2.58665896
44IgM deficiency (HP:0002850)2.57421752
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.57401113
46Acute necrotizing encephalopathy (HP:0006965)2.56202203
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54317505
483-Methylglutaconic aciduria (HP:0003535)2.53777840
49Abnormality of midbrain morphology (HP:0002418)2.53130280
50Molar tooth sign on MRI (HP:0002419)2.53130280
51Lipid accumulation in hepatocytes (HP:0006561)2.52459262
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51181048
53Bone marrow hypocellularity (HP:0005528)2.49566631
54Small intestinal stenosis (HP:0012848)2.47898268
55Duodenal stenosis (HP:0100867)2.47898268
56Respiratory difficulties (HP:0002880)2.47828478
57Aplasia/Hypoplasia of the patella (HP:0006498)2.45915249
58Cellular immunodeficiency (HP:0005374)2.43987664
59Microretrognathia (HP:0000308)2.43679678
60Congenital primary aphakia (HP:0007707)2.42864576
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41769326
62Methylmalonic acidemia (HP:0002912)2.40767315
63Type 2 muscle fiber atrophy (HP:0003554)2.37739973
64Abnormal mitochondria in muscle tissue (HP:0008316)2.35344393
65Nephroblastoma (Wilms tumor) (HP:0002667)2.34096648
66Hepatic necrosis (HP:0002605)2.34053800
67Agnosia (HP:0010524)2.33404427
68Nephrogenic diabetes insipidus (HP:0009806)2.32662205
69Microvesicular hepatic steatosis (HP:0001414)2.32599527
70Exertional dyspnea (HP:0002875)2.29566045
71Gait imbalance (HP:0002141)2.28374329
72Volvulus (HP:0002580)2.25665844
73CNS hypomyelination (HP:0003429)2.24961527
74Sloping forehead (HP:0000340)2.24740942
75Pancreatic fibrosis (HP:0100732)2.23756465
76Genital tract atresia (HP:0001827)2.21991588
77Abnormal spermatogenesis (HP:0008669)2.21870912
78Muscle fiber atrophy (HP:0100295)2.20122889
79Embryonal renal neoplasm (HP:0011794)2.19937483
80Abnormality of serum amino acid levels (HP:0003112)2.18942150
81Abnormality of the labia minora (HP:0012880)2.17589449
82Medulloblastoma (HP:0002885)2.17184998
83Abnormality of methionine metabolism (HP:0010901)2.16844758
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.15255740
85Vaginal atresia (HP:0000148)2.14898449
86Abnormal trabecular bone morphology (HP:0100671)2.14766257
87Renal cortical cysts (HP:0000803)2.13978330
88Asplenia (HP:0001746)2.13318423
89Nephronophthisis (HP:0000090)2.10435637
90Acute encephalopathy (HP:0006846)2.09806861
91Short tibia (HP:0005736)2.08996135
92Abnormal biliary tract physiology (HP:0012439)2.08993414
93Bile duct proliferation (HP:0001408)2.08993414
94Septo-optic dysplasia (HP:0100842)2.06896307
95Renal Fanconi syndrome (HP:0001994)2.06368797
96Degeneration of anterior horn cells (HP:0002398)2.05475880
97Abnormality of the anterior horn cell (HP:0006802)2.05475880
98Thrombocytosis (HP:0001894)2.05268367
99Duplicated collecting system (HP:0000081)2.04288797
100Abnormality of the duodenum (HP:0002246)2.04078395
101Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02854339
102Secondary amenorrhea (HP:0000869)2.02363609
103Carpal bone hypoplasia (HP:0001498)2.00749287
104Progressive macrocephaly (HP:0004481)2.00290822
105Hypoglycemic coma (HP:0001325)2.00280293
106Pulmonary fibrosis (HP:0002206)1.99863315
107Absent thumb (HP:0009777)1.99144754
108Pancreatic cysts (HP:0001737)1.98305717
109Methylmalonic aciduria (HP:0012120)1.97806889
110Lymphoma (HP:0002665)1.96401838
111Aplasia/Hypoplasia of the spleen (HP:0010451)1.95740101
112Bifid tongue (HP:0010297)1.95675835
113Optic nerve coloboma (HP:0000588)1.94698308
114Exercise intolerance (HP:0003546)1.94689567
115Horseshoe kidney (HP:0000085)1.94334816
116Intestinal atresia (HP:0011100)1.94043595
117Megaloblastic anemia (HP:0001889)1.93892776
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.93500089
119Rhabdomyosarcoma (HP:0002859)1.93036174
120Premature ovarian failure (HP:0008209)1.92000015
121Neoplasm of the pancreas (HP:0002894)1.91384221
122Irregular epiphyses (HP:0010582)1.90550567
123Abnormality of the pons (HP:0007361)1.89497003
124IgG deficiency (HP:0004315)1.89441779
125Respiratory failure (HP:0002878)1.89303035
126Tubulointerstitial nephritis (HP:0001970)1.88948536
127Increased intramyocellular lipid droplets (HP:0012240)1.88938575
128Triphalangeal thumb (HP:0001199)1.88396629
129Lactic acidosis (HP:0003128)1.88274350
130Hypoplasia of the pons (HP:0012110)1.87997304
131Hyperinsulinemic hypoglycemia (HP:0000825)1.86492497
132Absent radius (HP:0003974)1.83417983
133Abnormal glycosylation (HP:0012345)1.82760986
134Abnormal protein N-linked glycosylation (HP:0012347)1.82760986
135Leukodystrophy (HP:0002415)1.81985653
136Abnormality of serine family amino acid metabolism (HP:0010894)1.81896803
137Abnormality of glycine metabolism (HP:0010895)1.81896803
138Clubbing of toes (HP:0100760)1.80215538
139Optic nerve hypoplasia (HP:0000609)1.79450778
140Abnormality of the renal cortex (HP:0011035)1.78182804
141Poor coordination (HP:0002370)1.78105605
142Type II lissencephaly (HP:0007260)1.78032549
143Dandy-Walker malformation (HP:0001305)1.77667408
144Optic disc pallor (HP:0000543)1.77148697
145Sclerocornea (HP:0000647)1.76900599
146Chronic hepatic failure (HP:0100626)1.74553357
147Preaxial hand polydactyly (HP:0001177)1.74114926
148Lethargy (HP:0001254)1.73277865
149Abnormality of the renal medulla (HP:0100957)1.72977127
150Hypothermia (HP:0002045)1.70620926
151Ependymoma (HP:0002888)1.70037800
152Hyperglycinuria (HP:0003108)1.69561056
153Astigmatism (HP:0000483)1.69475353
154Glioma (HP:0009733)1.68404266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.22400685
2EIF2AK13.71683176
3CDC73.57037762
4WEE13.48593628
5STK163.26522376
6SRPK12.97243967
7EIF2AK32.89071066
8TSSK62.85551369
9MAP4K22.65581114
10VRK12.65117360
11FRK2.35991773
12PLK42.27780561
13TRIM282.27229621
14PBK2.14919513
15ACVR1B2.05863544
16WNK31.98406878
17BRSK21.96647947
18MKNK11.92746680
19NME21.90076129
20PLK31.88264999
21TTK1.81741645
22PLK11.81115073
23BCKDK1.80450852
24TLK11.73268596
25TESK21.72376072
26CCNB11.68875345
27VRK21.54480548
28MKNK21.53381360
29MAP3K41.44817887
30ATR1.42403792
31PIM21.40028759
32PASK1.39950855
33AURKB1.36281856
34NEK21.34885574
35MAP3K121.33716723
36ERBB31.33089161
37CDK71.33014769
38STK38L1.32999191
39CDK81.32291793
40BMPR1B1.31205904
41TGFBR11.30717221
42BRAF1.18786660
43DYRK31.18624465
44CHEK21.17881077
45MST41.14756483
46STK391.14556967
47TIE11.13344175
48PINK11.11342440
49EIF2AK21.08923515
50BRSK11.08166159
51TEC1.08056617
52ZAK1.06872258
53NME11.05703539
54NEK11.04712753
55CSNK1G11.04620839
56TAF11.00074740
57AURKA0.98442844
58TXK0.97306190
59FLT30.94081010
60RPS6KB20.87775656
61BRD40.84959642
62ATM0.84036620
63WNK40.82278715
64CHEK10.80651123
65CSNK1A1L0.79828441
66STK30.79818464
67CSNK1G20.78002918
68KDR0.77885842
69BMPR20.77129830
70ADRBK20.75982596
71PNCK0.74956853
72FGFR20.74432781
73STK100.73672303
74MAP3K60.72269192
75CSNK2A10.71705022
76OXSR10.71336259
77CDK190.70657396
78RPS6KA40.70509579
79CSNK2A20.69899111
80PDK20.69567157
81PIM10.63199580
82KIT0.60815881
83DAPK10.60197810
84PLK20.58299092
85AKT30.57763613
86MAPK130.56806281
87PRKCG0.56512618
88RPS6KA50.56475203
89LIMK10.55710174
90STK240.55578715
91JAK30.55420053
92CDK40.55331414
93BTK0.54790061
94PRPF4B0.53957328
95MUSK0.52837125
96CDK20.52678625
97CLK10.52664759
98YES10.50716295
99INSRR0.50482035
100PRKCI0.50341062
101ARAF0.50134768
102FGFR10.48270440
103MINK10.48224140
104DYRK20.47932262
105CDK10.47084433
106STK40.46564406
107MAP3K80.46562036
108CSNK1E0.45918198
109ABL20.45317683
110NUAK10.44582560
111TAOK20.44424256
112PRKCE0.44085136
113BCR0.44053767
114MAPKAPK50.43413511
115GRK10.42784421
116NEK60.41934206
117PAK30.40045419
118EPHA40.39813375
119CSNK1A10.39272260
120CASK0.38197275
121LYN0.37949317
122PRKDC0.37619125
123MAP4K10.36787444
124RAF10.36730409
125MAP3K140.36640299
126SCYL20.36037005
127ERBB40.35294384
128IRAK40.35163733
129CDK30.33446154
130PAK40.32258609
131CSNK1G30.31652700
132MAP2K70.31174226
133CSNK1D0.30650997
134TNIK0.30147252
135PRKACB0.29655759
136ZAP700.29435944
137PAK10.29330990
138OBSCN0.29147535
139MELK0.28627279
140LATS10.27761353

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.71730108
2Mismatch repair_Homo sapiens_hsa034304.07974944
3Proteasome_Homo sapiens_hsa030503.88366178
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.77688214
5Ribosome_Homo sapiens_hsa030103.72069262
6RNA polymerase_Homo sapiens_hsa030203.70311404
7Spliceosome_Homo sapiens_hsa030403.07525798
8Homologous recombination_Homo sapiens_hsa034403.06160695
9Nucleotide excision repair_Homo sapiens_hsa034203.00273593
10RNA transport_Homo sapiens_hsa030132.78313089
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73667409
12Base excision repair_Homo sapiens_hsa034102.70123478
13Pyrimidine metabolism_Homo sapiens_hsa002402.67558821
14Non-homologous end-joining_Homo sapiens_hsa034502.56668145
15Basal transcription factors_Homo sapiens_hsa030222.45150450
16Cell cycle_Homo sapiens_hsa041102.41809921
17Propanoate metabolism_Homo sapiens_hsa006402.35334496
18Fanconi anemia pathway_Homo sapiens_hsa034602.34617979
19RNA degradation_Homo sapiens_hsa030182.21865847
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17204076
21One carbon pool by folate_Homo sapiens_hsa006702.15000201
22Protein export_Homo sapiens_hsa030602.09143625
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81276120
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72542507
25Butanoate metabolism_Homo sapiens_hsa006501.71826944
26Purine metabolism_Homo sapiens_hsa002301.66794262
27Steroid biosynthesis_Homo sapiens_hsa001001.53094793
28Pyruvate metabolism_Homo sapiens_hsa006201.40929885
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39601769
30Oxidative phosphorylation_Homo sapiens_hsa001901.33476486
31Parkinsons disease_Homo sapiens_hsa050121.26020115
32mRNA surveillance pathway_Homo sapiens_hsa030151.25610215
33p53 signaling pathway_Homo sapiens_hsa041151.20470941
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14235293
35Phototransduction_Homo sapiens_hsa047441.13793130
36Huntingtons disease_Homo sapiens_hsa050161.11257083
37Folate biosynthesis_Homo sapiens_hsa007901.09299293
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05967708
39Epstein-Barr virus infection_Homo sapiens_hsa051691.05638293
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.03630741
41Peroxisome_Homo sapiens_hsa041460.88530527
42Primary immunodeficiency_Homo sapiens_hsa053400.85216697
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.83751080
44Herpes simplex infection_Homo sapiens_hsa051680.82885512
45Vitamin B6 metabolism_Homo sapiens_hsa007500.81052654
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79220053
47Nitrogen metabolism_Homo sapiens_hsa009100.78640773
48Antigen processing and presentation_Homo sapiens_hsa046120.78529066
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78149071
50Fatty acid metabolism_Homo sapiens_hsa012120.77366220
51Allograft rejection_Homo sapiens_hsa053300.75927482
52Tryptophan metabolism_Homo sapiens_hsa003800.75575672
53Systemic lupus erythematosus_Homo sapiens_hsa053220.75461393
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75155715
55Pentose phosphate pathway_Homo sapiens_hsa000300.75075491
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.74552646
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72999202
58Fatty acid degradation_Homo sapiens_hsa000710.71789462
59Sulfur metabolism_Homo sapiens_hsa009200.71282182
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.69657399
61Nicotine addiction_Homo sapiens_hsa050330.67877059
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67642926
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66437817
64Oocyte meiosis_Homo sapiens_hsa041140.65187147
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63366372
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62616696
67Alzheimers disease_Homo sapiens_hsa050100.62412856
68Cardiac muscle contraction_Homo sapiens_hsa042600.60669257
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59268490
70Biosynthesis of amino acids_Homo sapiens_hsa012300.59107192
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56466226
72beta-Alanine metabolism_Homo sapiens_hsa004100.54361080
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53978917
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53270432
75Graft-versus-host disease_Homo sapiens_hsa053320.52440257
76Glutathione metabolism_Homo sapiens_hsa004800.49757455
77Viral carcinogenesis_Homo sapiens_hsa052030.49704062
78Retinol metabolism_Homo sapiens_hsa008300.47241451
79Selenocompound metabolism_Homo sapiens_hsa004500.46676641
80Metabolic pathways_Homo sapiens_hsa011000.45181118
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44748741
82Lysine degradation_Homo sapiens_hsa003100.44608887
83Arachidonic acid metabolism_Homo sapiens_hsa005900.44465534
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.44445691
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43768053
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43548340
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42448274
88Sulfur relay system_Homo sapiens_hsa041220.42208470
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42058453
90Caffeine metabolism_Homo sapiens_hsa002320.41803400
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41555084
92Hedgehog signaling pathway_Homo sapiens_hsa043400.41422944
93Arginine and proline metabolism_Homo sapiens_hsa003300.41295096
94HTLV-I infection_Homo sapiens_hsa051660.40808988
95Taste transduction_Homo sapiens_hsa047420.40554974
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40445474
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39957716
98Legionellosis_Homo sapiens_hsa051340.38913787
99Autoimmune thyroid disease_Homo sapiens_hsa053200.38491374
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.36475949
101Olfactory transduction_Homo sapiens_hsa047400.36313819
102Chemical carcinogenesis_Homo sapiens_hsa052040.36258900
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35810514
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35158717
105Basal cell carcinoma_Homo sapiens_hsa052170.34747252
106N-Glycan biosynthesis_Homo sapiens_hsa005100.34539330
107Asthma_Homo sapiens_hsa053100.34517942
108Hematopoietic cell lineage_Homo sapiens_hsa046400.32994347
109Measles_Homo sapiens_hsa051620.30562797
110Collecting duct acid secretion_Homo sapiens_hsa049660.28515905
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28043155
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.27514114
113Circadian rhythm_Homo sapiens_hsa047100.27134501
114Hippo signaling pathway_Homo sapiens_hsa043900.26790313
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26295032
116Regulation of autophagy_Homo sapiens_hsa041400.25903869
117Carbon metabolism_Homo sapiens_hsa012000.25532456
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25207604
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25190297
120Galactose metabolism_Homo sapiens_hsa000520.23609060
121Type I diabetes mellitus_Homo sapiens_hsa049400.23536028
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23511871
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23277402
124Thyroid cancer_Homo sapiens_hsa052160.22175320
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20241793
126Fatty acid elongation_Homo sapiens_hsa000620.20179009
127Linoleic acid metabolism_Homo sapiens_hsa005910.19943637
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18807645
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.18527953
130Apoptosis_Homo sapiens_hsa042100.16585096
131Renin-angiotensin system_Homo sapiens_hsa046140.14551802
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14253493
133TGF-beta signaling pathway_Homo sapiens_hsa043500.14234123
134Shigellosis_Homo sapiens_hsa051310.12743718
135Vitamin digestion and absorption_Homo sapiens_hsa049770.12275124
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11795822
137Malaria_Homo sapiens_hsa051440.11406508
138Alcoholism_Homo sapiens_hsa050340.09775659
139Hepatitis B_Homo sapiens_hsa051610.09599708
140Ether lipid metabolism_Homo sapiens_hsa005650.08861009
141Influenza A_Homo sapiens_hsa051640.07086054
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.05406867
143Fructose and mannose metabolism_Homo sapiens_hsa000510.05138076

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