TRMT112P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone-serine phosphorylation (GO:0035404)9.43988262
2epithelial cell fate commitment (GO:0072148)9.11213691
3neuron fate determination (GO:0048664)8.68623601
4histone H2B ubiquitination (GO:0033523)8.43992231
5protein localization to microtubule cytoskeleton (GO:0072698)7.99929258
6positive regulation of histone H3-K4 methylation (GO:0051571)7.97019575
7cell fate commitment involved in formation of primary germ layer (GO:0060795)7.48521702
8positive regulation of oligodendrocyte differentiation (GO:0048714)7.24818283
9regulation of acrosome reaction (GO:0060046)7.05127040
10protein localization to cytoskeleton (GO:0044380)6.91708432
11peptidyl-lysine trimethylation (GO:0018023)6.91651578
12positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)6.77103411
13positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)6.43354276
14regulation of spindle organization (GO:0090224)6.41151253
15centrosome localization (GO:0051642)6.35017713
16spinal cord motor neuron differentiation (GO:0021522)6.34310389
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.18448510
18acrosome reaction (GO:0007340)6.14746091
19type B pancreatic cell development (GO:0003323)5.91616228
20astrocyte differentiation (GO:0048708)5.89036133
21positive regulation of DNA-templated transcription, initiation (GO:2000144)5.75426609
22deoxyribose phosphate biosynthetic process (GO:0046385)5.70123898
232-deoxyribonucleotide biosynthetic process (GO:0009265)5.70123898
24histone H3-K4 methylation (GO:0051568)5.67371992
25regulation of spindle checkpoint (GO:0090231)5.54914886
26neuron projection extension (GO:1990138)5.40656134
27response to folic acid (GO:0051593)5.39455113
28regulation of oligodendrocyte differentiation (GO:0048713)5.24087559
29spliceosomal complex assembly (GO:0000245)5.23730458
30intestinal epithelial cell development (GO:0060576)5.19379018
31positive regulation of glial cell differentiation (GO:0045687)4.92791465
32glycine transport (GO:0015816)4.92611127
33pre-miRNA processing (GO:0031054)4.89784885
34olfactory bulb development (GO:0021772)4.87954643
35proline transport (GO:0015824)4.74570821
36regulation of gene expression by genetic imprinting (GO:0006349)4.73404501
37cellular response to interleukin-6 (GO:0071354)4.67806305
38artery development (GO:0060840)4.65600490
39negative regulation of glial cell proliferation (GO:0060253)4.55132054
40urinary tract smooth muscle contraction (GO:0014848)4.50126516
41glandular epithelial cell development (GO:0002068)4.49196587
42pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)4.40762421
43central nervous system projection neuron axonogenesis (GO:0021952)4.36871485
44columnar/cuboidal epithelial cell development (GO:0002066)4.30189011
45adult feeding behavior (GO:0008343)4.28321026
46peptidyl-lysine methylation (GO:0018022)4.28153900
47response to progesterone (GO:0032570)4.23241847
48developmental cell growth (GO:0048588)4.05933055
49myelin assembly (GO:0032288)4.05699125
50pyrimidine nucleoside monophosphate metabolic process (GO:0009129)4.05270816
51regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)4.04107359
52response to vitamin A (GO:0033189)4.03518344
53detection of light stimulus involved in visual perception (GO:0050908)4.02805936
54detection of light stimulus involved in sensory perception (GO:0050962)4.02805936
55cell differentiation in spinal cord (GO:0021515)4.01423828
56inner ear receptor cell development (GO:0060119)4.00941444
57positive regulation of neurological system process (GO:0031646)3.99028164
58purinergic nucleotide receptor signaling pathway (GO:0035590)3.95273785
59forebrain neuron differentiation (GO:0021879)3.90033812
60regulation of histone H3-K4 methylation (GO:0051569)3.89351443
61deoxyribonucleotide biosynthetic process (GO:0009263)3.83814118
62response to interleukin-6 (GO:0070741)3.82343189
63pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.81922441
64spindle assembly (GO:0051225)3.77812191
65neuron fate specification (GO:0048665)3.69621644
66regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.68548848
67regulation of sister chromatid cohesion (GO:0007063)3.65471166
68genetic imprinting (GO:0071514)3.61291900
69peristalsis (GO:0030432)3.61158641
70nerve development (GO:0021675)3.58067998
71epithelial cell maturation (GO:0002070)3.54845227
72glycerol ether metabolic process (GO:0006662)3.54228405
73positive regulation of gliogenesis (GO:0014015)3.53656076
74female gonad development (GO:0008585)3.53532928
75negative regulation of microtubule depolymerization (GO:0007026)3.52151480
76regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)3.50838621
77central nervous system neuron axonogenesis (GO:0021955)3.49246003
78negative regulation of keratinocyte proliferation (GO:0010839)3.43541077
79cranial nerve development (GO:0021545)3.40124617
80myotube differentiation (GO:0014902)3.39701610
81negative regulation of dendrite development (GO:2000171)3.35437771
82histone phosphorylation (GO:0016572)3.35391111
83regulation of DNA-templated transcription, initiation (GO:2000142)3.35180407
84positive regulation of histone methylation (GO:0031062)3.31921633
85positive regulation of cell cycle G2/M phase transition (GO:1902751)3.31666564
86positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.31666564
87reciprocal meiotic recombination (GO:0007131)3.31408578
88reciprocal DNA recombination (GO:0035825)3.31408578
89ether metabolic process (GO:0018904)3.31019758
90regulation of centrosome cycle (GO:0046605)3.28803233
91axon extension (GO:0048675)3.27429700
92single strand break repair (GO:0000012)3.26679274
93histone monoubiquitination (GO:0010390)3.25701854
94mitotic spindle organization (GO:0007052)3.25365925
95positive regulation of DNA-templated transcription, elongation (GO:0032786)3.23264270
96C4-dicarboxylate transport (GO:0015740)3.20697683
97regulation of calcium ion-dependent exocytosis (GO:0017158)3.18829019
98histone H3-K4 trimethylation (GO:0080182)11.9901627
99interleukin-6-mediated signaling pathway (GO:0070102)10.5353865
100regulation of cell maturation (GO:1903429)10.3198388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human6.53768223
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.46323137
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.03311371
4VDR_22108803_ChIP-Seq_LS180_Human3.32033082
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.99437202
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.98291077
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.64609737
8EZH2_22144423_ChIP-Seq_EOC_Human2.58292187
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.57791532
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42990396
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39698993
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.38768386
13PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.28751190
14P53_22127205_ChIP-Seq_FIBROBLAST_Human2.28094687
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.14612640
16PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.13432767
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11797292
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09087677
19SCL_19346495_ChIP-Seq_HPC-7_Human2.05332793
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.99898776
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.96093365
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.88136772
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85940130
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.83932045
25E2F7_22180533_ChIP-Seq_HELA_Human1.81112668
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78697320
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76401011
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74250041
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70780281
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65739553
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65739553
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59692441
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57556083
34TAF15_26573619_Chip-Seq_HEK293_Human1.55101390
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.55010848
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52818524
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49982379
38BCAT_22108803_ChIP-Seq_LS180_Human1.49879471
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49488927
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.48621636
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47329472
42CBP_20019798_ChIP-Seq_JUKART_Human1.44667653
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44667653
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.41136353
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.40990559
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37164527
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.35289933
48SMAD3_21741376_ChIP-Seq_HESCs_Human1.34526231
49TCF3_18692474_ChIP-Seq_MESCs_Mouse1.31860365
50TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29450833
51AR_21572438_ChIP-Seq_LNCaP_Human1.28852979
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28237485
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25902656
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25475472
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25336077
56FUS_26573619_Chip-Seq_HEK293_Human1.24202372
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22592130
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.20488400
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16921789
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15361713
61P300_19829295_ChIP-Seq_ESCs_Human1.15128679
62E2F1_20622854_ChIP-Seq_HELA_Human1.13592203
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11380931
64KDM2B_26808549_Chip-Seq_REH_Human1.10915632
65CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09189341
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09179350
67RNF2_27304074_Chip-Seq_NSC_Mouse1.08850144
68TCF4_23295773_ChIP-Seq_U87_Human1.07127406
69REST_21632747_ChIP-Seq_MESCs_Mouse1.06700299
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05532362
71ZNF274_21170338_ChIP-Seq_K562_Hela1.05018061
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04222985
73JUN_21703547_ChIP-Seq_K562_Human1.02930111
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02831529
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.02580227
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.02418898
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01540680
78SMAD4_21799915_ChIP-Seq_A2780_Human1.01069921
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00630054
80TP53_22573176_ChIP-Seq_HFKS_Human0.98632547
81SMAD4_21741376_ChIP-Seq_EPCs_Human0.98063225
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97999872
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97977866
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95984652
85TP53_20018659_ChIP-ChIP_R1E_Mouse0.95842929
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94512300
87AHR_22903824_ChIP-Seq_MCF-7_Human0.93499371
88TCF4_22108803_ChIP-Seq_LS180_Human0.93131067
89RING1B_27294783_Chip-Seq_NPCs_Mouse0.92189937
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91966045
91RXR_22108803_ChIP-Seq_LS180_Human0.90927138
92DROSHA_22980978_ChIP-Seq_HELA_Human0.89908595
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88556322
94TAF2_19829295_ChIP-Seq_ESCs_Human0.88171639
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87837298
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86970763
97STAT3_23295773_ChIP-Seq_U87_Human0.85682677
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84617232
99EWS_26573619_Chip-Seq_HEK293_Human0.83548621
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81289399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.76192314
2MP0009780_abnormal_chondrocyte_physiolo6.04750087
3MP0003787_abnormal_imprinting5.40553951
4MP0003693_abnormal_embryo_hatching5.10214598
5MP0008877_abnormal_DNA_methylation4.36944328
6MP0003183_abnormal_peptide_metabolism3.67213389
7MP0003122_maternal_imprinting3.13739351
8MP0006276_abnormal_autonomic_nervous3.02852018
9MP0009053_abnormal_anal_canal2.97717605
10MP0010234_abnormal_vibrissa_follicle2.85394917
11MP0003195_calcinosis2.74911600
12MP0010678_abnormal_skin_adnexa2.70248298
13MP0000383_abnormal_hair_follicle2.63958632
14MP0003950_abnormal_plasma_membrane2.62675108
15MP0005360_urolithiasis2.59365533
16MP0003880_abnormal_central_pattern2.56845741
17MP0002735_abnormal_chemical_nociception2.39107544
18MP0006072_abnormal_retinal_apoptosis2.35060059
19MP0001968_abnormal_touch/_nociception2.16307297
20MP0003121_genomic_imprinting1.96469912
21MP0008789_abnormal_olfactory_epithelium1.74551589
22MP0000569_abnormal_digit_pigmentation1.70513333
23MP0004924_abnormal_behavior1.65284239
24MP0005386_behavior/neurological_phenoty1.65284239
25MP0008007_abnormal_cellular_replicative1.52288347
26MP0002168_other_aberrant_phenotype1.46542869
27MP0004885_abnormal_endolymph1.45096833
28MP0005394_taste/olfaction_phenotype1.34716440
29MP0005499_abnormal_olfactory_system1.34716440
30MP0002098_abnormal_vibrissa_morphology1.34018630
31MP0003385_abnormal_body_wall1.31855626
32MP0000428_abnormal_craniofacial_morphol1.28262933
33MP0003045_fibrosis1.24420927
34MP0009250_abnormal_appendicular_skeleto1.17468845
35MP0003878_abnormal_ear_physiology1.15935062
36MP0005377_hearing/vestibular/ear_phenot1.15935062
37MP0003077_abnormal_cell_cycle1.15394237
38MP0002127_abnormal_cardiovascular_syste1.09339867
39MP0009672_abnormal_birth_weight1.08064472
40MP0002751_abnormal_autonomic_nervous1.05631437
41MP0002736_abnormal_nociception_after1.04828670
42MP0003252_abnormal_bile_duct1.03010732
43MP0005551_abnormal_eye_electrophysiolog1.01511385
44MP0002111_abnormal_tail_morphology1.00930523
45MP0010094_abnormal_chromosome_stability0.99319669
46MP0000534_abnormal_ureter_morphology0.99054307
47MP0005253_abnormal_eye_physiology0.97900619
48MP0000955_abnormal_spinal_cord0.97493244
49MP0000733_abnormal_muscle_development0.86268284
50MP0002063_abnormal_learning/memory/cond0.85960344
51MP0009764_decreased_sensitivity_to0.85470401
52MP0001324_abnormal_eye_pigmentation0.82434971
53MP0005365_abnormal_bile_salt0.82408570
54MP0003119_abnormal_digestive_system0.80374765
55MP0003137_abnormal_impulse_conducting0.80245109
56MP0000750_abnormal_muscle_regeneration0.76376885
57MP0005195_abnormal_posterior_eye0.69759694
58MP0000778_abnormal_nervous_system0.69022419
59MP0003635_abnormal_synaptic_transmissio0.68280467
60MP0002184_abnormal_innervation0.67486485
61MP0002109_abnormal_limb_morphology0.65777094
62MP0005395_other_phenotype0.65213151
63MP0005248_abnormal_Harderian_gland0.65196857
64MP0001944_abnormal_pancreas_morphology0.65188750
65MP0003755_abnormal_palate_morphology0.63914072
66MP0003698_abnormal_male_reproductive0.62411599
67MP0000350_abnormal_cell_proliferation0.61996054
68MP0003861_abnormal_nervous_system0.60552501
69MP0001502_abnormal_circadian_rhythm0.60244939
70MP0002102_abnormal_ear_morphology0.60142506
71MP0002114_abnormal_axial_skeleton0.59313467
72MP0002752_abnormal_somatic_nervous0.58346206
73MP0002115_abnormal_skeleton_extremities0.57808500
74MP0003699_abnormal_female_reproductive0.56008692
75MP0001919_abnormal_reproductive_system0.55942809
76MP0000537_abnormal_urethra_morphology0.53837608
77MP0001970_abnormal_pain_threshold0.53386468
78MP0010771_integument_phenotype0.52928795
79MP0001756_abnormal_urination0.52450199
80MP0002572_abnormal_emotion/affect_behav0.52101265
81MP0004019_abnormal_vitamin_homeostasis0.52061755
82MP0001663_abnormal_digestive_system0.51959022
83MP0002882_abnormal_neuron_morphology0.50840835
84MP0004133_heterotaxia0.50500397
85MP0000026_abnormal_inner_ear0.49878549
86MP0003937_abnormal_limbs/digits/tail_de0.49496148
87MP0001765_abnormal_ion_homeostasis0.49091134
88MP0000377_abnormal_hair_follicle0.47140633
89MP0009703_decreased_birth_body0.46328025
90MP0002161_abnormal_fertility/fecundity0.46282954
91MP0002733_abnormal_thermal_nociception0.45713784
92MP0002909_abnormal_adrenal_gland0.44896623
93MP0003111_abnormal_nucleus_morphology0.44611546
94MP0003935_abnormal_craniofacial_develop0.43508343
95MP0003942_abnormal_urinary_system0.43380255
96MP0002081_perinatal_lethality0.43275275
97MP0001929_abnormal_gametogenesis0.43084304
98MP0005171_absent_coat_pigmentation0.42040114
99MP0000653_abnormal_sex_gland0.41354573
100MP0002249_abnormal_larynx_morphology0.41076099

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)8.30434070
2Dry hair (HP:0011359)6.15474296
3Short 1st metacarpal (HP:0010034)5.47042272
4Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.47042272
5Truncal obesity (HP:0001956)5.25023304
6Constricted visual fields (HP:0001133)4.91271824
7Abnormality of the 1st metacarpal (HP:0010009)4.88395359
8Long clavicles (HP:0000890)4.81916429
9Intrahepatic cholestasis (HP:0001406)4.64664757
10Radial bowing (HP:0002986)4.64050310
11Vertebral arch anomaly (HP:0008438)4.41160489
12Proximal placement of thumb (HP:0009623)4.25534863
13Hydroxyprolinuria (HP:0003080)3.85466390
14Abnormality of proline metabolism (HP:0010907)3.85466390
15Hypoplastic ischia (HP:0003175)3.76881436
16Deviation of the thumb (HP:0009603)3.73878374
17Cerebral aneurysm (HP:0004944)3.73771964
18Short phalanx of the thumb (HP:0009660)3.58137570
19Bony spicule pigmentary retinopathy (HP:0007737)3.50700627
20Increased nuchal translucency (HP:0010880)3.42793485
21Vertebral clefting (HP:0008428)3.36047072
22Papillary thyroid carcinoma (HP:0002895)3.30479276
23Abnormality of the ischium (HP:0003174)3.25544998
24Neoplasm of the tracheobronchial system (HP:0100552)3.22055840
25Slow-growing hair (HP:0002217)3.16681255
26Abnormality of hair growth rate (HP:0011363)3.16681255
27Long palpebral fissure (HP:0000637)3.15396510
28Ulnar bowing (HP:0003031)3.09460423
29Aplasia/Hypoplasia of the scapulae (HP:0006713)3.02530720
30Hypoplastic scapulae (HP:0000882)3.02530720
31Confusion (HP:0001289)3.02427693
32Blepharitis (HP:0000498)2.96861448
33Short middle phalanx of finger (HP:0005819)2.96208482
34Woolly hair (HP:0002224)2.94789185
35Bowing of the arm (HP:0006488)2.93599141
36Bowed forearm bones (HP:0003956)2.93599141
37Medulloblastoma (HP:0002885)2.91387292
38Abnormality of the aortic arch (HP:0012303)2.90989280
39Abnormality of the prostate (HP:0008775)2.85820359
40Hypotrichosis (HP:0001006)2.81921982
41Chronic bronchitis (HP:0004469)2.79653894
42Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.79093423
43Choroideremia (HP:0001139)2.78137527
44Pachygyria (HP:0001302)2.73489907
45Lissencephaly (HP:0001339)2.66798180
46Optic disc pallor (HP:0000543)2.66075192
47Limited elbow extension (HP:0001377)2.64816715
48Hemivertebrae (HP:0002937)2.63328268
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.62204561
50Decreased circulating renin level (HP:0003351)2.61238579
51Poor speech (HP:0002465)2.55775768
52Abnormality of the fingertips (HP:0001211)2.55598450
53Hyperactive renin-angiotensin system (HP:0000841)2.54268549
54Rhabdomyosarcoma (HP:0002859)2.52946499
55Low anterior hairline (HP:0000294)2.49601611
56Decreased central vision (HP:0007663)2.49197512
57Thoracic kyphosis (HP:0002942)2.47938002
58Hypoalphalipoproteinemia (HP:0003233)2.46195230
59Lip pit (HP:0100267)2.40525625
60Hyperglycinuria (HP:0003108)2.31802694
61Large earlobe (HP:0009748)2.31104690
62Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.30302202
63Thick eyebrow (HP:0000574)2.28009862
64Abnormality of the lumbar spine (HP:0100712)2.25750891
65Rib fusion (HP:0000902)2.25594508
66Supernumerary bones of the axial skeleton (HP:0009144)2.24139450
67Abnormality of the epiphyses of the hand (HP:0005924)2.23624516
68Abnormality of the nasal septum (HP:0000419)2.22253950
69Exostoses (HP:0100777)2.21400881
70Aplasia/Hypoplasia of the nipples (HP:0006709)2.19507130
71Intestinal malrotation (HP:0002566)2.17866674
72Abnormality of the middle phalanges of the hand (HP:0009833)2.16807800
73Cutis marmorata (HP:0000965)2.12924962
74Abnormality of the sella turcica (HP:0002679)2.11614012
75Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.09956252
76Autoimmune thrombocytopenia (HP:0001973)2.09803535
77Neoplasm of striated muscle (HP:0009728)2.07191463
78Abnormality of male internal genitalia (HP:0000022)2.07093190
79Low posterior hairline (HP:0002162)2.06626406
80Short nail (HP:0001799)2.06248357
81Postnatal growth retardation (HP:0008897)2.03997055
82Hyperkalemia (HP:0002153)2.02662789
83Intestinal fistula (HP:0100819)2.02228067
84Hypoplastic iliac wings (HP:0002866)2.01256325
85Hypokalemic alkalosis (HP:0001949)1.93676790
86Lymphangioma (HP:0100764)1.93277426
87Broad metatarsal (HP:0001783)1.92660336
88Atresia of the external auditory canal (HP:0000413)1.89922810
89Atrioventricular canal defect (HP:0006695)1.86871319
90Muscular hypotonia of the trunk (HP:0008936)1.86416343
91Thyroid carcinoma (HP:0002890)1.86401455
92Fine hair (HP:0002213)1.83650010
93Gastroesophageal reflux (HP:0002020)1.82005369
94Cerebral edema (HP:0002181)1.77791276
95Redundant skin (HP:0001582)1.75505396
96Acute necrotizing encephalopathy (HP:0006965)1.75117993
97Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72726118
98Short 4th metacarpal (HP:0010044)1.72726118
99Supernumerary ribs (HP:0005815)1.71949341
100Coarse hair (HP:0002208)1.71893018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.92123763
2TAF14.45832225
3CASK3.63706028
4PIK3CG2.56680143
5ARAF2.10993273
6PNCK2.05655320
7MAP3K913.7555103
8MAP3K131.94470470
9DDR21.42615095
10VRK21.42166591
11NTRK21.16666361
12MOS0.98418074
13KSR20.87901025
14BRAF0.87877611
15AURKA0.85577968
16SMG10.83959439
17MATK0.81570056
18CDK90.77581352
19TYRO30.77156010
20GRK10.72061777
21PAK10.66563809
22MAPK40.61998100
23TNIK0.60922205
24SGK20.59885942
25NEK90.58230371
26CAMK1G0.56454763
27AKT30.55991260
28BUB10.55836094
29AURKB0.49793194
30KSR10.45163735
31MAP2K10.44395464
32RAF10.44135995
33PBK0.38099120
34PRKCH0.38018256
35CSNK1G30.37839673
36FGR0.36986010
37SGK4940.35527239
38SGK2230.35527239
39NUAK10.35473654
40GRK60.34016872
41CSNK1G10.32852398
42TSSK60.32515845
43VRK10.31809970
44CSNK1A1L0.31066452
45CDC42BPA0.31038285
46CHEK20.30439290
47RPS6KB10.29995556
48CDK70.29178436
49SGK30.28682019
50GRK50.28218272
51RPS6KA20.27876874
52INSRR0.27745931
53CDK11A0.27216899
54CSNK1G20.25734171
55CDK50.24245223
56ATM0.22716241
57DAPK10.18676156
58RPS6KA30.18199197
59MAP3K70.18117460
60CSNK2A20.18103733
61MAPKAPK50.17512649
62ACVR1B0.17287817
63CSNK1E0.16767941
64PRKG10.15870477
65MAPK130.14960027
66GSK3B0.14272329
67CDK150.14045400
68PRKDC0.13938975
69PDGFRA0.13803192
70CDK180.12425555
71RPS6KA60.10765212
72PRKCG0.10184876
73CSNK1D0.09878398
74FRK0.09839455
75MINK10.09227171
76RPS6KC10.07781618
77RPS6KL10.07781618
78BMPR1B0.07539635
79ABL10.06989042
80PRKACG0.06007717
81PLK20.05516626
82MAP3K80.05337434
83PRKACB0.05300094
84BRSK10.05243531
85MAPK80.05037767
86PRKCB0.04891887
87CDK20.04611983
88DYRK20.04305420
89CDK140.04303560
90CCNB10.04185873
91CHEK10.03877582
92DAPK30.03619031
93PRKACA0.03185873
94PAK30.02612519
95PLK10.02501665
96SRPK10.02312938
97RIPK40.02095067
98MAPK30.01572776
99CAMK40.01479404
100FYN0.01375330

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005336.69987401
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.59472017
3One carbon pool by folate_Homo sapiens_hsa006704.17858045
4Basal transcription factors_Homo sapiens_hsa030224.09607745
5Taste transduction_Homo sapiens_hsa047422.64979902
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45381677
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43339487
8Oocyte meiosis_Homo sapiens_hsa041141.98501725
9Prion diseases_Homo sapiens_hsa050201.77351807
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.68030087
11Basal cell carcinoma_Homo sapiens_hsa052171.66452281
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46701848
13Cell cycle_Homo sapiens_hsa041101.44473372
14Hedgehog signaling pathway_Homo sapiens_hsa043401.41405717
15Bladder cancer_Homo sapiens_hsa052191.40890431
16Tryptophan metabolism_Homo sapiens_hsa003801.39721960
17Nicotine addiction_Homo sapiens_hsa050331.38809903
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35425785
19Butanoate metabolism_Homo sapiens_hsa006501.27936781
20Axon guidance_Homo sapiens_hsa043601.26785992
21Asthma_Homo sapiens_hsa053101.20404261
22Melanogenesis_Homo sapiens_hsa049161.17501414
23RNA transport_Homo sapiens_hsa030131.09009829
24Propanoate metabolism_Homo sapiens_hsa006401.08022810
25Chemical carcinogenesis_Homo sapiens_hsa052041.07007400
26Prolactin signaling pathway_Homo sapiens_hsa049171.05571750
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05165462
28Endometrial cancer_Homo sapiens_hsa052130.99846883
29Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92857516
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92368220
31Pyruvate metabolism_Homo sapiens_hsa006200.90739560
32Fatty acid biosynthesis_Homo sapiens_hsa000610.89771942
33Sphingolipid metabolism_Homo sapiens_hsa006000.88914339
34Colorectal cancer_Homo sapiens_hsa052100.87872092
35Intestinal immune network for IgA production_Homo sapiens_hsa046720.85328962
36Arachidonic acid metabolism_Homo sapiens_hsa005900.82703360
37Vascular smooth muscle contraction_Homo sapiens_hsa042700.82107678
38TGF-beta signaling pathway_Homo sapiens_hsa043500.78954090
39Olfactory transduction_Homo sapiens_hsa047400.78853171
40Thyroid hormone synthesis_Homo sapiens_hsa049180.78801357
41Thyroid cancer_Homo sapiens_hsa052160.77607178
42Melanoma_Homo sapiens_hsa052180.76515348
43Spliceosome_Homo sapiens_hsa030400.72653024
44Wnt signaling pathway_Homo sapiens_hsa043100.70467577
45Salivary secretion_Homo sapiens_hsa049700.69952070
46Autoimmune thyroid disease_Homo sapiens_hsa053200.69753808
47Gap junction_Homo sapiens_hsa045400.67016142
48Calcium signaling pathway_Homo sapiens_hsa040200.66905306
49Allograft rejection_Homo sapiens_hsa053300.66575467
50Glutathione metabolism_Homo sapiens_hsa004800.63663687
51Prostate cancer_Homo sapiens_hsa052150.63627134
52Graft-versus-host disease_Homo sapiens_hsa053320.62182827
53Homologous recombination_Homo sapiens_hsa034400.60968129
54Alzheimers disease_Homo sapiens_hsa050100.58311196
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56245753
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54068612
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52988488
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51948925
59Long-term potentiation_Homo sapiens_hsa047200.51252465
60Oxytocin signaling pathway_Homo sapiens_hsa049210.50249886
61Dorso-ventral axis formation_Homo sapiens_hsa043200.49363763
62Type I diabetes mellitus_Homo sapiens_hsa049400.48717737
63Oxidative phosphorylation_Homo sapiens_hsa001900.46421678
64Lysine degradation_Homo sapiens_hsa003100.45819765
65Circadian entrainment_Homo sapiens_hsa047130.44151283
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43497931
67B cell receptor signaling pathway_Homo sapiens_hsa046620.42959140
68Huntingtons disease_Homo sapiens_hsa050160.41017019
69Cocaine addiction_Homo sapiens_hsa050300.39170261
70GABAergic synapse_Homo sapiens_hsa047270.38742097
71Chemokine signaling pathway_Homo sapiens_hsa040620.38003595
72Insulin resistance_Homo sapiens_hsa049310.37936717
73T cell receptor signaling pathway_Homo sapiens_hsa046600.37727263
74Mineral absorption_Homo sapiens_hsa049780.37348792
75Morphine addiction_Homo sapiens_hsa050320.37164263
76Phototransduction_Homo sapiens_hsa047440.36092690
77Ovarian steroidogenesis_Homo sapiens_hsa049130.34656591
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32527432
79Viral myocarditis_Homo sapiens_hsa054160.32466421
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.30886406
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30687046
82Serotonergic synapse_Homo sapiens_hsa047260.30395106
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29520018
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29262238
85Cardiac muscle contraction_Homo sapiens_hsa042600.28686786
86Estrogen signaling pathway_Homo sapiens_hsa049150.28145309
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.28057233
88Linoleic acid metabolism_Homo sapiens_hsa005910.27354650
89Insulin secretion_Homo sapiens_hsa049110.26900278
90Tight junction_Homo sapiens_hsa045300.26544424
91Adherens junction_Homo sapiens_hsa045200.26048740
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25772635
93Notch signaling pathway_Homo sapiens_hsa043300.24169581
94Glutamatergic synapse_Homo sapiens_hsa047240.22238587
95MicroRNAs in cancer_Homo sapiens_hsa052060.22133293
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.22099200
97Caffeine metabolism_Homo sapiens_hsa002320.21459675
98Protein digestion and absorption_Homo sapiens_hsa049740.20159750
99Focal adhesion_Homo sapiens_hsa045100.20079627
100Nitrogen metabolism_Homo sapiens_hsa009100.19773731

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