TRMT112P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)7.26699655
2cytidine deamination (GO:0009972)7.26699655
3cytidine metabolic process (GO:0046087)7.26699655
4pyrimidine ribonucleoside catabolic process (GO:0046133)6.61742023
5DNA deamination (GO:0045006)5.88462507
6regulation of chronic inflammatory response (GO:0002676)4.95991891
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.84744841
8regulation of activation of Janus kinase activity (GO:0010533)4.77971769
9regulation of isotype switching to IgG isotypes (GO:0048302)4.76533581
10positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.59295938
11Arp2/3 complex-mediated actin nucleation (GO:0034314)4.46268930
12positive regulation of activated T cell proliferation (GO:0042104)4.36901183
13CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.28609511
14regulation of regulatory T cell differentiation (GO:0045589)4.21205802
15negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.19550836
16regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.13828299
17actin nucleation (GO:0045010)4.12320961
18positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.04843083
19positive regulation of natural killer cell mediated immunity (GO:0002717)3.97486381
20positive regulation of interleukin-17 production (GO:0032740)3.94620561
21behavioral response to nicotine (GO:0035095)3.94037658
22positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.89159611
23positive regulation of defense response to virus by host (GO:0002230)3.83672786
24cellular response to interleukin-15 (GO:0071350)3.81488594
25positive regulation of interleukin-8 secretion (GO:2000484)3.76555264
26positive regulation of cell killing (GO:0031343)3.69248026
27regulation of interleukin-12 biosynthetic process (GO:0045075)3.67565647
28positive regulation of natural killer cell differentiation (GO:0032825)3.57049439
29regulation of leukocyte mediated cytotoxicity (GO:0001910)3.56666763
30positive regulation of T cell mediated cytotoxicity (GO:0001916)3.55285657
31negative regulation of B cell proliferation (GO:0030889)3.54096529
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50993262
33regulation of memory T cell differentiation (GO:0043380)3.50871587
34regulation of T cell mediated cytotoxicity (GO:0001914)3.49447763
35regulation of cell killing (GO:0031341)3.48940900
36positive regulation of cell fate commitment (GO:0010455)3.43757372
37DNA demethylation (GO:0080111)3.43189885
38regulation of natural killer cell differentiation (GO:0032823)3.42939061
39regulation of interleukin-8 secretion (GO:2000482)3.42019865
40ATP synthesis coupled proton transport (GO:0015986)3.38087670
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38087670
42alpha-beta T cell differentiation involved in immune response (GO:0002293)3.36736116
43alpha-beta T cell activation involved in immune response (GO:0002287)3.36736116
44T cell differentiation involved in immune response (GO:0002292)3.36736116
45negative regulation of mast cell activation (GO:0033004)3.31820688
46ribosomal small subunit assembly (GO:0000028)3.27690687
47positive regulation of chemokine biosynthetic process (GO:0045080)3.24527346
48regulation of activated T cell proliferation (GO:0046006)3.22561846
49protein neddylation (GO:0045116)3.22339239
50positive regulation of isotype switching (GO:0045830)3.21515856
51pyrimidine nucleoside catabolic process (GO:0046135)3.15407095
52regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.14319867
53regulation of natural killer cell mediated immunity (GO:0002715)3.14319867
54regulation of proton transport (GO:0010155)3.13292870
55negative regulation of T-helper cell differentiation (GO:0045623)3.11864798
56negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.11864798
57positive regulation of interleukin-10 production (GO:0032733)3.11085759
58CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.08356265
59T-helper cell differentiation (GO:0042093)3.08356265
60regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.07563638
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06420054
62mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05543961
63response to interleukin-15 (GO:0070672)3.05348663
64negative regulation by host of viral transcription (GO:0043922)3.03289685
65regulation of natural killer cell activation (GO:0032814)3.00164275
66negative regulation of alpha-beta T cell differentiation (GO:0046639)2.99567362
67negative regulation of B cell activation (GO:0050869)2.93920772
68response to pheromone (GO:0019236)2.89835621
69positive regulation of B cell differentiation (GO:0045579)2.89243705
70positive regulation of natural killer cell activation (GO:0032816)2.85220899
71regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.85008371
72positive regulation of DNA recombination (GO:0045911)2.84628020
73platelet dense granule organization (GO:0060155)2.83585669
74negative regulation of acute inflammatory response (GO:0002674)2.82890131
75negative regulation of T cell differentiation (GO:0045581)2.82006361
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81911028
77positive regulation of calcium-mediated signaling (GO:0050850)2.81039199
78regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.80080126
79negative T cell selection (GO:0043383)2.79903259
80eosinophil chemotaxis (GO:0048245)2.79766329
81cellular defense response (GO:0006968)2.75625745
82regulation of T-helper cell differentiation (GO:0045622)2.75596955
83regulation of interleukin-10 production (GO:0032653)2.72657879
84positive regulation of lymphocyte mediated immunity (GO:0002708)2.72158427
85respiratory electron transport chain (GO:0022904)2.71288801
86electron transport chain (GO:0022900)2.71245856
87positive regulation of immunoglobulin production (GO:0002639)2.70612409
88intestinal epithelial cell development (GO:0060576)2.70427291
89positive T cell selection (GO:0043368)2.68634666
90negative regulation of calcium ion transport into cytosol (GO:0010523)2.66291864
91regulation of podosome assembly (GO:0071801)2.65922293
92regulation of cellular amino acid metabolic process (GO:0006521)2.64405135
93positive regulation of interleukin-1 beta secretion (GO:0050718)2.63330895
94hydrogen ion transmembrane transport (GO:1902600)2.62930862
95regulation of vitamin D biosynthetic process (GO:0060556)2.62738260
96sequestering of actin monomers (GO:0042989)2.62422524
97negative regulation of lymphocyte differentiation (GO:0045620)2.60065154
98lymphocyte costimulation (GO:0031294)2.59257396
99regulation of chemokine biosynthetic process (GO:0045073)2.58898839
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.58224198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.35193441
2EZH2_22144423_ChIP-Seq_EOC_Human5.96836355
3VDR_22108803_ChIP-Seq_LS180_Human3.79178720
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34558097
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.28319780
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17466943
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.11708549
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.76523886
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.67845529
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54849443
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49818476
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34927106
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.27567966
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18813301
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.10245880
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90724301
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89507599
18GATA3_26560356_Chip-Seq_TH2_Human1.83526691
19ZNF274_21170338_ChIP-Seq_K562_Hela1.73524662
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71115511
21MYB_26560356_Chip-Seq_TH2_Human1.64239933
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62276318
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.58311907
24TP53_22573176_ChIP-Seq_HFKS_Human1.55843893
25RUNX_20019798_ChIP-Seq_JUKART_Human1.55411799
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54972617
27VDR_23849224_ChIP-Seq_CD4+_Human1.54714461
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.51003073
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.48623646
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44729942
31HTT_18923047_ChIP-ChIP_STHdh_Human1.42843167
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42289370
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38844982
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38610281
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37218898
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34369796
37NANOG_20526341_ChIP-Seq_ESCs_Human1.28490145
38PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27846080
39GATA3_21878914_ChIP-Seq_MCF-7_Human1.26477736
40MYC_19829295_ChIP-Seq_ESCs_Human1.24550344
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21276513
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20870455
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.20870455
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19080636
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.17905460
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16524480
47ER_23166858_ChIP-Seq_MCF-7_Human1.16275964
48P53_21459846_ChIP-Seq_SAOS-2_Human1.15512056
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15162970
50TAF2_19829295_ChIP-Seq_ESCs_Human1.14549879
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.13647842
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.13549405
53IGF1R_20145208_ChIP-Seq_DFB_Human1.12994087
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12298137
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12011099
56TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11472123
57NCOR_22424771_ChIP-Seq_293T_Human1.10598293
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09815467
59GATA3_27048872_Chip-Seq_THYMUS_Human1.05432382
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04557787
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03362460
62AR_20517297_ChIP-Seq_VCAP_Human1.01989376
63NANOG_19829295_ChIP-Seq_ESCs_Human1.01445253
64SOX2_19829295_ChIP-Seq_ESCs_Human1.01445253
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99928004
66YY1_21170310_ChIP-Seq_MESCs_Mouse0.98247037
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97474078
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97322431
69TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96697900
70BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96602169
71EZH2_27294783_Chip-Seq_ESCs_Mouse0.96428641
72CTCF_20526341_ChIP-Seq_ESCs_Human0.95967026
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93381185
74YY1_22570637_ChIP-Seq_MALME-3M_Human0.92977709
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92535223
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92492986
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91062738
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91018497
79IRF8_21731497_ChIP-ChIP_J774_Mouse0.90869930
80FOXH1_21741376_ChIP-Seq_EPCs_Human0.90728876
81RBPJ_21746931_ChIP-Seq_IB4_Human0.90210284
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89990641
83ERA_21632823_ChIP-Seq_H3396_Human0.89833261
84IRF1_19129219_ChIP-ChIP_H3396_Human0.89421858
85FOXP3_21729870_ChIP-Seq_TREG_Human0.88648610
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87806815
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87521363
88OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87102497
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86751256
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86751256
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86751256
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86321128
93MYC_18940864_ChIP-ChIP_HL60_Human0.85828668
94SA1_27219007_Chip-Seq_Bcells_Human0.85603953
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85285069
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84582079
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83866702
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.83156925
99GATA3_21867929_ChIP-Seq_TH1_Mouse0.82512592
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.82316097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation5.04342498
2MP0005671_abnormal_response_to4.02439053
3MP0001835_abnormal_antigen_presentation3.32191234
4MP0009333_abnormal_splenocyte_physiolog2.88444185
5MP0006082_CNS_inflammation2.69559108
6MP0002163_abnormal_gland_morphology2.63817089
7MP0000569_abnormal_digit_pigmentation2.58957188
8MP0005075_abnormal_melanosome_morpholog2.40425047
9MP0009785_altered_susceptibility_to2.26352402
10MP0005000_abnormal_immune_tolerance2.25987271
11MP0008872_abnormal_physiological_respon2.23385248
12MP0003195_calcinosis2.11366302
13MP0001919_abnormal_reproductive_system2.09852745
14MP0002166_altered_tumor_susceptibility2.05615907
15MP0005387_immune_system_phenotype2.03386704
16MP0001790_abnormal_immune_system2.03386704
17MP0003763_abnormal_thymus_physiology1.92023656
18MP0001348_abnormal_lacrimal_gland1.91513546
19MP0006072_abnormal_retinal_apoptosis1.90968600
20MP0001800_abnormal_humoral_immune1.90744607
21MP0005310_abnormal_salivary_gland1.80920358
22MP0003866_abnormal_defecation1.72686138
23MP0002006_tumorigenesis1.66536094
24MP0002723_abnormal_immune_serum1.65342262
25MP0005174_abnormal_tail_pigmentation1.63537977
26MP0003183_abnormal_peptide_metabolism1.62436852
27MP0002102_abnormal_ear_morphology1.60523526
28MP0005025_abnormal_response_to1.58397404
29MP0005389_reproductive_system_phenotype1.58090841
30MP0005408_hypopigmentation1.54818575
31MP0003011_delayed_dark_adaptation1.53158902
32MP0002148_abnormal_hypersensitivity_rea1.52087437
33MP0008875_abnormal_xenobiotic_pharmacok1.50041035
34MP0002420_abnormal_adaptive_immunity1.49454005
35MP0004742_abnormal_vestibular_system1.45342218
36MP0002933_joint_inflammation1.43810416
37MP0001819_abnormal_immune_cell1.43286506
38MP0005379_endocrine/exocrine_gland_phen1.37477038
39MP0005646_abnormal_pituitary_gland1.35890234
40MP0002876_abnormal_thyroid_physiology1.32498167
41MP0002452_abnormal_antigen_presenting1.30735202
42MP0001765_abnormal_ion_homeostasis1.26272003
43MP0005551_abnormal_eye_electrophysiolog1.21928132
44MP0001188_hyperpigmentation1.19443840
45MP0001905_abnormal_dopamine_level1.17342242
46MP0005084_abnormal_gallbladder_morpholo1.13640912
47MP0003567_abnormal_fetal_cardiomyocyte1.13046895
48MP0001986_abnormal_taste_sensitivity1.11229029
49MP0002272_abnormal_nervous_system1.08687265
50MP0010155_abnormal_intestine_physiology1.08626296
51MP0001845_abnormal_inflammatory_respons1.06198398
52MP0001663_abnormal_digestive_system1.05857423
53MP0000015_abnormal_ear_pigmentation1.05476922
54MP0001529_abnormal_vocalization1.05173603
55MP0000372_irregular_coat_pigmentation1.04457995
56MP0001968_abnormal_touch/_nociception1.03863233
57MP0009379_abnormal_foot_pigmentation1.01084812
58MP0000685_abnormal_immune_system1.00920163
59MP0002638_abnormal_pupillary_reflex1.00906905
60MP0005645_abnormal_hypothalamus_physiol1.00494994
61MP0009764_decreased_sensitivity_to0.98250174
62MP0002095_abnormal_skin_pigmentation0.96547865
63MP0002234_abnormal_pharynx_morphology0.94993250
64MP0002405_respiratory_system_inflammati0.94872583
65MP0003724_increased_susceptibility_to0.93611181
66MP0000716_abnormal_immune_system0.93384540
67MP0009745_abnormal_behavioral_response0.93051974
68MP0005377_hearing/vestibular/ear_phenot0.91300783
69MP0003878_abnormal_ear_physiology0.91300783
70MP0001853_heart_inflammation0.89239964
71MP0008877_abnormal_DNA_methylation0.87555880
72MP0005253_abnormal_eye_physiology0.86906114
73MP0002398_abnormal_bone_marrow0.85676164
74MP0004147_increased_porphyrin_level0.84570565
75MP0003950_abnormal_plasma_membrane0.83706265
76MP0000703_abnormal_thymus_morphology0.82220765
77MP0002822_catalepsy0.81397596
78MP0000689_abnormal_spleen_morphology0.80730206
79MP0002282_abnormal_trachea_morphology0.80249083
80MP0001119_abnormal_female_reproductive0.78235205
81MP0008789_abnormal_olfactory_epithelium0.78168909
82MP0002210_abnormal_sex_determination0.76721436
83MP0005647_abnormal_sex_gland0.74344685
84MP0005410_abnormal_fertilization0.73849280
85MP0002722_abnormal_immune_system0.73205704
86MP0002429_abnormal_blood_cell0.73161174
87MP0005636_abnormal_mineral_homeostasis0.72991303
88MP0004885_abnormal_endolymph0.72821174
89MP0000427_abnormal_hair_cycle0.72733014
90MP0004381_abnormal_hair_follicle0.71734569
91MP0002693_abnormal_pancreas_physiology0.71520088
92MP0000639_abnormal_adrenal_gland0.70450738
93MP0006276_abnormal_autonomic_nervous0.70382003
94MP0002419_abnormal_innate_immunity0.70022228
95MP0003448_altered_tumor_morphology0.69464668
96MP0008469_abnormal_protein_level0.69290653
97MP0002138_abnormal_hepatobiliary_system0.68550120
98MP0003786_premature_aging0.68259550
99MP0009765_abnormal_xenobiotic_induced0.67931644
100MP0008995_early_reproductive_senescence0.67532259

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the prostate (HP:0008775)4.28456789
2Congenital stationary night blindness (HP:0007642)3.97933649
3Acute necrotizing encephalopathy (HP:0006965)3.71271939
4Abnormal mitochondria in muscle tissue (HP:0008316)3.52332393
5Mitochondrial inheritance (HP:0001427)3.36075492
6Abolished electroretinogram (ERG) (HP:0000550)3.24448686
7T lymphocytopenia (HP:0005403)3.21841653
8Abnormality of T cell number (HP:0011839)3.15618187
9IgG deficiency (HP:0004315)3.09034562
10Absent rod-and cone-mediated responses on ERG (HP:0007688)2.98692900
11Optic neuritis (HP:0100653)2.94628070
12Retrobulbar optic neuritis (HP:0100654)2.94628070
13Gangrene (HP:0100758)2.93132661
14Hypoproteinemia (HP:0003075)2.92738437
15Progressive macrocephaly (HP:0004481)2.90500515
16Abnormal rod and cone electroretinograms (HP:0008323)2.88393026
17Chronic obstructive pulmonary disease (HP:0006510)2.87975610
18Obstructive lung disease (HP:0006536)2.87975610
19Pulmonary infiltrates (HP:0002113)2.84950487
20Ureteral stenosis (HP:0000071)2.80944672
21Decreased activity of mitochondrial respiratory chain (HP:0008972)2.80270588
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.80270588
23Acute encephalopathy (HP:0006846)2.77970757
24Increased CSF lactate (HP:0002490)2.70692613
25Abnormality of male internal genitalia (HP:0000022)2.67101065
26Vitreoretinal degeneration (HP:0000655)2.65834763
27Septo-optic dysplasia (HP:0100842)2.63169363
28Chronic diarrhea (HP:0002028)2.61485973
29Congenital, generalized hypertrichosis (HP:0004540)2.60714987
30Severe combined immunodeficiency (HP:0004430)2.58250569
31Abnormal drinking behavior (HP:0030082)2.57235036
32Polydipsia (HP:0001959)2.57235036
33Abnormality of the renal cortex (HP:0011035)2.52183194
34Pulmonary fibrosis (HP:0002206)2.49715121
35Ureteral obstruction (HP:0006000)2.48901628
36Abnormality of T cells (HP:0002843)2.48834439
37Pancreatic fibrosis (HP:0100732)2.47047413
38True hermaphroditism (HP:0010459)2.40546586
39Prostate neoplasm (HP:0100787)2.38920714
40Myositis (HP:0100614)2.38849032
41Increased intramyocellular lipid droplets (HP:0012240)2.37567990
42Pancreatic cysts (HP:0001737)2.33507626
43Poor head control (HP:0002421)2.32256197
44Radial bowing (HP:0002986)2.29196582
45Renal Fanconi syndrome (HP:0001994)2.28270285
46Meningitis (HP:0001287)2.27999250
47Stomatitis (HP:0010280)2.27609092
48Seborrheic dermatitis (HP:0001051)2.24729413
49Tachypnea (HP:0002789)2.23572634
50Renal cortical cysts (HP:0000803)2.21075379
51Cerebral edema (HP:0002181)2.18252860
52Oral leukoplakia (HP:0002745)2.18058594
53Asplenia (HP:0001746)2.17170709
54Abnormal albumin level (HP:0012116)2.16220924
55Hypoalbuminemia (HP:0003073)2.16220924
56Polyneuropathy (HP:0001271)2.13766349
57Mediastinal lymphadenopathy (HP:0100721)2.13409871
58Rib fusion (HP:0000902)2.12103769
59Hepatocellular necrosis (HP:0001404)2.11811405
60Parakeratosis (HP:0001036)2.10775380
61Orchitis (HP:0100796)2.10750206
62Aplasia/Hypoplasia of the spleen (HP:0010451)2.10676033
63Hemoptysis (HP:0002105)2.10516791
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.05338691
65Albinism (HP:0001022)2.04356023
66Progressive microcephaly (HP:0000253)2.03704535
67Optic disc pallor (HP:0000543)2.02389478
68Abnormality of eosinophils (HP:0001879)2.01661707
69Pulmonary embolism (HP:0002204)2.00030396
70Aplastic anemia (HP:0001915)1.99884963
71Severe visual impairment (HP:0001141)1.99222825
72Autoimmune hemolytic anemia (HP:0001890)1.98559416
73Pancreatitis (HP:0001733)1.96909129
74Increased IgM level (HP:0003496)1.96831874
75Increased hepatocellular lipid droplets (HP:0006565)1.94371792
76Ketoacidosis (HP:0001993)1.93571490
77Elevated erythrocyte sedimentation rate (HP:0003565)1.92375237
78Increased muscle lipid content (HP:0009058)1.92077135
79Type 2 muscle fiber atrophy (HP:0003554)1.91503302
80Medial flaring of the eyebrow (HP:0010747)1.90188203
81Tinnitus (HP:0000360)1.90160209
82Hypophosphatemic rickets (HP:0004912)1.89391946
83Pigmentary retinal degeneration (HP:0001146)1.88045477
84Molar tooth sign on MRI (HP:0002419)1.87320097
85Abnormality of midbrain morphology (HP:0002418)1.87320097
86Generalized aminoaciduria (HP:0002909)1.86248570
87Abnormality of magnesium homeostasis (HP:0004921)1.86236318
88Gastrointestinal infarctions (HP:0005244)1.86000618
89Hepatic necrosis (HP:0002605)1.84316247
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84209496
91Encephalitis (HP:0002383)1.83437245
92Forearm undergrowth (HP:0009821)1.82969875
93Keratoconjunctivitis (HP:0001096)1.82003455
94Thyroiditis (HP:0100646)1.81760214
95Severe muscular hypotonia (HP:0006829)1.81162672
96Vasculitis (HP:0002633)1.80603101
97Hypotrichosis (HP:0001006)1.80599384
98Aplasia/Hypoplasia of the ulna (HP:0006495)1.80510804
99Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79141923
100Hypoplasia of the ulna (HP:0003022)1.78138398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.02270263
2STK165.36688332
3KDR3.15086021
4WNK42.56913707
5WNK32.50615538
6CDK192.09457645
7NME12.00050642
8EPHA31.97548848
9ADRBK21.90850665
10BMPR1B1.83652633
11MAP3K121.82671884
12MAP4K21.81116362
13ITK1.74354020
14TESK21.71501779
15TLK11.70170146
16TSSK61.66421958
17BMPR21.63675464
18BCKDK1.63262211
19GRK11.61246003
20MATK1.53958000
21PLK41.43587034
22STK391.43314564
23IKBKB1.36712271
24MAP2K21.36157135
25RIPK41.32941867
26PAK61.30650550
27BRD41.30353289
28CAMKK21.23877408
29IRAK41.17940973
30TYRO31.17141284
31ZAK1.16578889
32DYRK21.14551751
33SYK1.07266160
34PIK3CG1.03119396
35VRK11.02710825
36LIMK11.00873320
37TIE10.99997619
38PRKD30.98357028
39OXSR10.97447689
40VRK20.94569293
41MAP2K70.94074906
42LCK0.93552555
43IKBKE0.90864033
44MYLK0.87319973
45TAOK30.86297644
46PRKCQ0.85536265
47INSRR0.84791308
48CSK0.81139018
49MAPK150.80251527
50JAK20.73841915
51ILK0.64437499
52NLK0.62940412
53LYN0.58863265
54MAPK110.58274793
55PASK0.57295591
56GRK70.54427063
57MAP3K40.53713720
58TNK20.53317109
59RPS6KA50.52317858
60FES0.51063678
61IGF1R0.50185409
62DAPK30.49695277
63MST40.49549568
64CAMKK10.48922779
65TBK10.48708675
66WNK10.46178593
67PKN10.44766246
68PRKCE0.44153026
69PHKG10.43193906
70PHKG20.43193906
71ZAP700.42936660
72ALK0.42860934
73IRAK10.42520864
74OBSCN0.41750236
75NUAK10.41697331
76LRRK20.41029363
77PAK10.39230156
78EIF2AK10.38976492
79MAPK130.38858095
80TEC0.38128528
81DAPK10.34419813
82PRKCG0.33854301
83PBK0.33567569
84PRKACA0.33323322
85ADRBK10.32935892
86ROCK10.32693200
87PRKCA0.31049916
88CDK80.30160881
89EPHB10.29805122
90PRKCH0.29542150
91PRKCD0.28552809
92STK38L0.28483650
93SIK30.28462178
94PIK3CA0.27737027
95HIPK20.27689553
96PIM10.27552788
97ABL20.26449402
98PRKCZ0.26078205
99PIM20.25446609
100CHUK0.24581116

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053204.17918622
2Allograft rejection_Homo sapiens_hsa053303.92091021
3Proteasome_Homo sapiens_hsa030503.89973530
4Oxidative phosphorylation_Homo sapiens_hsa001903.33294334
5Primary immunodeficiency_Homo sapiens_hsa053403.13755069
6Asthma_Homo sapiens_hsa053103.07242435
7Parkinsons disease_Homo sapiens_hsa050122.96648687
8Graft-versus-host disease_Homo sapiens_hsa053322.85732552
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.69471407
10Antigen processing and presentation_Homo sapiens_hsa046122.53550147
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.38350030
12Hematopoietic cell lineage_Homo sapiens_hsa046402.32333194
13Ribosome_Homo sapiens_hsa030102.29394099
14T cell receptor signaling pathway_Homo sapiens_hsa046602.21501507
15Type I diabetes mellitus_Homo sapiens_hsa049402.08299572
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.94036096
17Rheumatoid arthritis_Homo sapiens_hsa053231.84513192
18Alzheimers disease_Homo sapiens_hsa050101.79880816
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77317907
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74785338
21Phototransduction_Homo sapiens_hsa047441.74125604
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64293942
23Huntingtons disease_Homo sapiens_hsa050161.61069920
24Cardiac muscle contraction_Homo sapiens_hsa042601.57019708
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55066405
26RNA polymerase_Homo sapiens_hsa030201.33992000
27DNA replication_Homo sapiens_hsa030301.26254292
28Linoleic acid metabolism_Homo sapiens_hsa005911.24059231
29Measles_Homo sapiens_hsa051621.15797386
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14136680
31Mismatch repair_Homo sapiens_hsa034301.13223434
32Caffeine metabolism_Homo sapiens_hsa002321.11867787
33One carbon pool by folate_Homo sapiens_hsa006701.08647018
34Vitamin digestion and absorption_Homo sapiens_hsa049771.08500528
35Nitrogen metabolism_Homo sapiens_hsa009101.05367945
36Protein export_Homo sapiens_hsa030601.04622782
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04458243
38Olfactory transduction_Homo sapiens_hsa047400.99211112
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99145965
40Jak-STAT signaling pathway_Homo sapiens_hsa046300.92086799
41Collecting duct acid secretion_Homo sapiens_hsa049660.91508082
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89488390
43Legionellosis_Homo sapiens_hsa051340.87351750
44Arachidonic acid metabolism_Homo sapiens_hsa005900.84942517
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72307269
46Viral myocarditis_Homo sapiens_hsa054160.72305579
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.69635447
48Homologous recombination_Homo sapiens_hsa034400.69546882
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67697032
50Chemical carcinogenesis_Homo sapiens_hsa052040.61067853
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59889252
52Nicotine addiction_Homo sapiens_hsa050330.58708067
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.58135638
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.57483869
55RNA degradation_Homo sapiens_hsa030180.57443777
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56787026
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56628877
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53911939
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52610329
60Pyrimidine metabolism_Homo sapiens_hsa002400.52461765
61Leishmaniasis_Homo sapiens_hsa051400.51200916
62Malaria_Homo sapiens_hsa051440.49915240
63RNA transport_Homo sapiens_hsa030130.48395861
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47629669
65Salmonella infection_Homo sapiens_hsa051320.46839279
66Fanconi anemia pathway_Homo sapiens_hsa034600.45730367
67African trypanosomiasis_Homo sapiens_hsa051430.44535974
68Retinol metabolism_Homo sapiens_hsa008300.42929627
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41454888
70Peroxisome_Homo sapiens_hsa041460.38719664
71Taste transduction_Homo sapiens_hsa047420.37843068
72Systemic lupus erythematosus_Homo sapiens_hsa053220.37558839
73Butanoate metabolism_Homo sapiens_hsa006500.36844407
74Shigellosis_Homo sapiens_hsa051310.36797319
75Hedgehog signaling pathway_Homo sapiens_hsa043400.35443355
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33560097
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32107851
78Fat digestion and absorption_Homo sapiens_hsa049750.31500223
79Spliceosome_Homo sapiens_hsa030400.31399620
80Morphine addiction_Homo sapiens_hsa050320.29692096
81Purine metabolism_Homo sapiens_hsa002300.27907888
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27356523
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26756186
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26568132
85Basal transcription factors_Homo sapiens_hsa030220.24344113
86Nucleotide excision repair_Homo sapiens_hsa034200.21961689
87GABAergic synapse_Homo sapiens_hsa047270.20816553
88Metabolic pathways_Homo sapiens_hsa011000.20481647
89Glutamatergic synapse_Homo sapiens_hsa047240.19069358
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19062178
91Influenza A_Homo sapiens_hsa051640.18192058
92Chemokine signaling pathway_Homo sapiens_hsa040620.17730230
93Serotonergic synapse_Homo sapiens_hsa047260.16808154
94Selenocompound metabolism_Homo sapiens_hsa004500.16404188
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.16116607
96Mineral absorption_Homo sapiens_hsa049780.16072832
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15637617
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.14948135
99Pertussis_Homo sapiens_hsa051330.14351458
100Tyrosine metabolism_Homo sapiens_hsa003500.14148143

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